KMT5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.39298001
2pyrimidine nucleobase catabolic process (GO:0006208)5.35752720
3presynaptic membrane organization (GO:0097090)4.80111789
4nucleobase catabolic process (GO:0046113)4.29083371
5negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.19511154
6negative regulation of translation, ncRNA-mediated (GO:0040033)4.19511154
7regulation of translation, ncRNA-mediated (GO:0045974)4.19511154
8neuron recognition (GO:0008038)4.18058921
9axonal fasciculation (GO:0007413)4.05876660
10establishment of nucleus localization (GO:0040023)3.95108702
11neuron cell-cell adhesion (GO:0007158)3.93482016
12neural tube formation (GO:0001841)3.83702224
13auditory behavior (GO:0031223)3.72627265
14postsynaptic membrane organization (GO:0001941)3.68483289
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.65334127
16negative regulation of oligodendrocyte differentiation (GO:0048715)3.50502062
17neurotransmitter-gated ion channel clustering (GO:0072578)3.50018635
18central nervous system projection neuron axonogenesis (GO:0021952)3.49813162
19histone H3-K4 trimethylation (GO:0080182)3.48986534
20limb bud formation (GO:0060174)3.48002156
21cerebral cortex radially oriented cell migration (GO:0021799)3.34994309
22positive regulation of dendritic spine morphogenesis (GO:0061003)3.34903463
23mechanosensory behavior (GO:0007638)3.27992192
24dendrite morphogenesis (GO:0048813)3.27081758
25synapse assembly (GO:0007416)3.15334960
26olfactory bulb development (GO:0021772)3.13284851
27embryonic retina morphogenesis in camera-type eye (GO:0060059)3.12113586
28neuronal stem cell maintenance (GO:0097150)3.12084693
29histone H3-K9 methylation (GO:0051567)3.10986624
30response to auditory stimulus (GO:0010996)3.09969254
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.07528729
32nucleus localization (GO:0051647)3.06454568
33peptidyl-lysine trimethylation (GO:0018023)3.05989312
34vocalization behavior (GO:0071625)3.01026174
35calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.99999886
36forebrain neuron differentiation (GO:0021879)2.99641129
37nonmotile primary cilium assembly (GO:0035058)2.95494910
38cell migration in hindbrain (GO:0021535)2.90232863
39histone H3-K9 modification (GO:0061647)2.83132023
40otic vesicle formation (GO:0030916)2.81568292
41neuron migration (GO:0001764)2.76557889
42glutamate receptor signaling pathway (GO:0007215)2.72845007
43substrate-independent telencephalic tangential migration (GO:0021826)2.72247547
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.72247547
45establishment of mitochondrion localization (GO:0051654)2.71911959
46apical protein localization (GO:0045176)2.71491167
47dendritic spine morphogenesis (GO:0060997)2.70774505
48phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.69053444
49spinal cord development (GO:0021510)2.68756139
50regulation of oligodendrocyte differentiation (GO:0048713)2.68568996
51somite development (GO:0061053)2.68244548
52cytoplasmic mRNA processing body assembly (GO:0033962)2.67836835
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66520627
54histone H3-K36 demethylation (GO:0070544)2.66436677
55central nervous system neuron axonogenesis (GO:0021955)2.65771725
56positive regulation of synapse assembly (GO:0051965)2.65235460
57negative regulation of neurotransmitter secretion (GO:0046929)2.64554599
58epithelial cilium movement (GO:0003351)2.63659652
59negative regulation of neurotransmitter transport (GO:0051589)2.60181026
60regulation of cilium movement (GO:0003352)2.58228817
61negative regulation of astrocyte differentiation (GO:0048712)2.58032869
62cerebral cortex cell migration (GO:0021795)2.57513991
63retrograde transport, vesicle recycling within Golgi (GO:0000301)2.57491668
64G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.56614051
65hippocampus development (GO:0021766)2.55606938
66positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55292739
67interkinetic nuclear migration (GO:0022027)2.54641258
68cerebral cortex neuron differentiation (GO:0021895)2.54494507
69establishment of protein localization to Golgi (GO:0072600)2.54461201
70synapse organization (GO:0050808)2.53548353
71hindbrain development (GO:0030902)2.51654998
72histone H4-K16 acetylation (GO:0043984)2.51345409
73heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.49228043
74regulation of collateral sprouting (GO:0048670)2.49201067
75epithelial cell differentiation involved in kidney development (GO:0035850)2.48828408
76axon ensheathment in central nervous system (GO:0032291)2.48792266
77central nervous system myelination (GO:0022010)2.48792266
78cochlea development (GO:0090102)2.48091730
79auditory receptor cell differentiation (GO:0042491)2.47140887
80startle response (GO:0001964)2.46752632
81regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.44605916
82brain morphogenesis (GO:0048854)2.44047483
83dendrite development (GO:0016358)2.43944572
84peptidyl-threonine dephosphorylation (GO:0035970)2.42953652
85positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.42778352
86regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.42778352
87mitotic sister chromatid cohesion (GO:0007064)2.42748133
88retinal ganglion cell axon guidance (GO:0031290)2.42652495
89negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.42426616
90regulation of axon guidance (GO:1902667)2.41896873
91retina layer formation (GO:0010842)2.41730558
92protein localization to synapse (GO:0035418)2.40100982
93gastrulation with mouth forming second (GO:0001702)2.40088410
94protein targeting to Golgi (GO:0000042)2.36555972
95tachykinin receptor signaling pathway (GO:0007217)2.36407331
96negative regulation of glial cell differentiation (GO:0045686)2.35550884
97regulation of NFAT protein import into nucleus (GO:0051532)2.34478051
98Sertoli cell development (GO:0060009)2.34324443
99intraciliary transport (GO:0042073)2.32958109
100positive regulation of action potential (GO:0045760)2.32506086

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.63630266
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.54229062
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.95032531
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.84609401
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.84461664
6GBX2_23144817_ChIP-Seq_PC3_Human2.70957068
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67227313
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44802468
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.43801812
10TAF15_26573619_Chip-Seq_HEK293_Human2.37845152
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30206000
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24247399
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.13419008
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.12254180
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.06882230
16FUS_26573619_Chip-Seq_HEK293_Human2.02371473
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00524223
18IGF1R_20145208_ChIP-Seq_DFB_Human2.00045465
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93907842
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90055599
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88522524
22P300_19829295_ChIP-Seq_ESCs_Human1.82070862
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81411891
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81081440
25MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80209507
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.74459288
27POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73713241
28TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73713241
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73605107
30OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70996640
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70557988
32AR_21572438_ChIP-Seq_LNCaP_Human1.68359031
33SMAD4_21799915_ChIP-Seq_A2780_Human1.67423132
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61778590
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.61258820
36REST_21632747_ChIP-Seq_MESCs_Mouse1.59327403
37RNF2_27304074_Chip-Seq_NSC_Mouse1.58041081
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.57943598
39STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.57780171
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.57343007
41ER_23166858_ChIP-Seq_MCF-7_Human1.55779564
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55495506
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54534057
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49298116
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.49254078
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46582904
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45124702
48VDR_22108803_ChIP-Seq_LS180_Human1.39847573
49STAT3_23295773_ChIP-Seq_U87_Human1.39352528
50EWS_26573619_Chip-Seq_HEK293_Human1.39228404
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.36122914
52AR_25329375_ChIP-Seq_VCAP_Human1.35415125
53LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34716522
54YAP1_20516196_ChIP-Seq_MESCs_Mouse1.33400453
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.33266545
56ZNF274_21170338_ChIP-Seq_K562_Hela1.32657849
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32610558
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31218957
59RUNX2_22187159_ChIP-Seq_PCA_Human1.28857212
60TCF4_23295773_ChIP-Seq_U87_Human1.28534256
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28266456
62WT1_19549856_ChIP-ChIP_CCG9911_Human1.27750698
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24339550
64EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22341895
65CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22336723
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20981202
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20536703
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19551206
69SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18526159
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.18339580
71TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18283299
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16773668
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.14292783
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14162934
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13333009
76DROSHA_22980978_ChIP-Seq_HELA_Human1.12164219
77BCAT_22108803_ChIP-Seq_LS180_Human1.11457823
78EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09966999
79RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09966999
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.09226883
81BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09005421
82CBP_20019798_ChIP-Seq_JUKART_Human1.08956997
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08956997
84TBX3_20139965_ChIP-Seq_MESCs_Mouse1.08680316
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08154497
86TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08037269
87FLI1_21867929_ChIP-Seq_TH2_Mouse1.07560103
88TAL1_26923725_Chip-Seq_HPCs_Mouse1.07220007
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06826118
90SOX9_26525672_Chip-Seq_HEART_Mouse1.05474167
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.05131048
92PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04633777
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03877851
94P53_22387025_ChIP-Seq_ESCs_Mouse1.03766647
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03204235
96AR_19668381_ChIP-Seq_PC3_Human1.02643954
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02196550
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.01555406
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01537919
100CMYC_18555785_Chip-Seq_ESCs_Mouse1.01255268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.63704962
2MP0000778_abnormal_nervous_system3.14603220
3MP0002822_catalepsy3.12140243
4MP0003890_abnormal_embryonic-extraembry2.64970017
5MP0003121_genomic_imprinting2.64664719
6MP0000566_synostosis2.64640767
7MP0003122_maternal_imprinting2.63121612
8MP0003880_abnormal_central_pattern2.46197191
9MP0008877_abnormal_DNA_methylation2.39322687
10MP0005248_abnormal_Harderian_gland2.24847072
11MP0003136_yellow_coat_color2.21763346
12MP0000569_abnormal_digit_pigmentation2.17530235
13MP0002735_abnormal_chemical_nociception2.07011490
14MP0005423_abnormal_somatic_nervous2.06601547
15MP0006292_abnormal_olfactory_placode2.02540068
16MP0004270_analgesia1.97131387
17MP0002009_preneoplasia1.93991741
18MP0004885_abnormal_endolymph1.89514064
19MP0001188_hyperpigmentation1.82995220
20MP0006276_abnormal_autonomic_nervous1.81387657
21MP0005409_darkened_coat_color1.80260128
22MP0003635_abnormal_synaptic_transmissio1.76227014
23MP0004859_abnormal_synaptic_plasticity1.74672846
24MP0002063_abnormal_learning/memory/cond1.70614551
25MP0000955_abnormal_spinal_cord1.69523966
26MP0002909_abnormal_adrenal_gland1.68049761
27MP0004742_abnormal_vestibular_system1.60884209
28MP0001486_abnormal_startle_reflex1.60486324
29MP0002653_abnormal_ependyma_morphology1.60061918
30MP0000537_abnormal_urethra_morphology1.58798767
31MP0001529_abnormal_vocalization1.55064124
32MP0002638_abnormal_pupillary_reflex1.53927558
33MP0002557_abnormal_social/conspecific_i1.52537056
34MP0003283_abnormal_digestive_organ1.50249961
35MP0002184_abnormal_innervation1.47050185
36MP0000631_abnormal_neuroendocrine_gland1.46841581
37MP0002736_abnormal_nociception_after1.39609571
38MP0002572_abnormal_emotion/affect_behav1.38530747
39MP0003861_abnormal_nervous_system1.38321128
40MP0002067_abnormal_sensory_capabilities1.36165519
41MP0001984_abnormal_olfaction1.35725379
42MP0003123_paternal_imprinting1.35590432
43MP0002152_abnormal_brain_morphology1.34876621
44MP0002734_abnormal_mechanical_nocicepti1.34538043
45MP0002882_abnormal_neuron_morphology1.31853019
46MP0002272_abnormal_nervous_system1.28207319
47MP0005187_abnormal_penis_morphology1.27489489
48MP0005386_behavior/neurological_phenoty1.27046577
49MP0004924_abnormal_behavior1.27046577
50MP0001440_abnormal_grooming_behavior1.26758327
51MP0005394_taste/olfaction_phenotype1.25355941
52MP0005499_abnormal_olfactory_system1.25355941
53MP0000383_abnormal_hair_follicle1.25290138
54MP0003938_abnormal_ear_development1.24636617
55MP0004811_abnormal_neuron_physiology1.20517882
56MP0003183_abnormal_peptide_metabolism1.20028983
57MP0002928_abnormal_bile_duct1.18369837
58MP0002938_white_spotting1.15275291
59MP0004142_abnormal_muscle_tone1.14924197
60MP0001485_abnormal_pinna_reflex1.13745141
61MP0001968_abnormal_touch/_nociception1.13704604
62MP0001286_abnormal_eye_development1.09015227
63MP0000049_abnormal_middle_ear1.04448468
64MP0002752_abnormal_somatic_nervous1.03871179
65MP0004147_increased_porphyrin_level1.03655502
66MP0002751_abnormal_autonomic_nervous1.02849937
67MP0004145_abnormal_muscle_electrophysio1.01578350
68MP0001324_abnormal_eye_pigmentation1.01165429
69MP0000462_abnormal_digestive_system1.00982848
70MP0005367_renal/urinary_system_phenotyp0.99006212
71MP0000516_abnormal_urinary_system0.99006212
72MP0008789_abnormal_olfactory_epithelium0.98976340
73MP0005174_abnormal_tail_pigmentation0.98068352
74MP0002697_abnormal_eye_size0.97818694
75MP0009745_abnormal_behavioral_response0.97075091
76MP0005645_abnormal_hypothalamus_physiol0.96496600
77MP0008057_abnormal_DNA_replication0.96228406
78MP0001970_abnormal_pain_threshold0.95353668
79MP0000026_abnormal_inner_ear0.94154769
80MP0002064_seizures0.91395589
81MP0003943_abnormal_hepatobiliary_system0.91122534
82MP0003315_abnormal_perineum_morphology0.90903511
83MP0001293_anophthalmia0.90418502
84MP0000534_abnormal_ureter_morphology0.88825144
85MP0003632_abnormal_nervous_system0.88027766
86MP0009703_decreased_birth_body0.87941345
87MP0004133_heterotaxia0.86346223
88MP0010678_abnormal_skin_adnexa0.85862911
89MP0002081_perinatal_lethality0.85706697
90MP0002233_abnormal_nose_morphology0.84560792
91MP0001177_atelectasis0.82703267
92MP0000647_abnormal_sebaceous_gland0.82551494
93MP0005195_abnormal_posterior_eye0.82161351
94MP0005253_abnormal_eye_physiology0.80009172
95MP0003935_abnormal_craniofacial_develop0.79822815
96MP0005377_hearing/vestibular/ear_phenot0.79548737
97MP0003878_abnormal_ear_physiology0.79548737
98MP0002733_abnormal_thermal_nociception0.78658130
99MP0002066_abnormal_motor_capabilities/c0.77673569
100MP0003119_abnormal_digestive_system0.77339223

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.60769114
2Hyperventilation (HP:0002883)3.51072198
3Volvulus (HP:0002580)3.42886607
4Progressive cerebellar ataxia (HP:0002073)3.32626036
5Drooling (HP:0002307)3.22816677
6Hepatoblastoma (HP:0002884)3.14763244
7Abnormal hair whorl (HP:0010721)3.10894002
8Excessive salivation (HP:0003781)3.04336540
9Focal motor seizures (HP:0011153)2.99393765
10Megalencephaly (HP:0001355)2.92735315
11Exotropia (HP:0000577)2.47531223
12Genetic anticipation (HP:0003743)2.46490646
13Febrile seizures (HP:0002373)2.38874073
14True hermaphroditism (HP:0010459)2.36763819
15Broad-based gait (HP:0002136)2.34849701
16Aqueductal stenosis (HP:0002410)2.33980162
17Medulloblastoma (HP:0002885)2.27120095
18Focal seizures (HP:0007359)2.23617510
19Thyroid carcinoma (HP:0002890)2.23259679
20Pancreatic fibrosis (HP:0100732)2.23081641
21Genital tract atresia (HP:0001827)2.19587057
22Midline defect of the nose (HP:0004122)2.17453909
23Oligodactyly (hands) (HP:0001180)2.14725912
24Shawl scrotum (HP:0000049)2.14129000
25Cupped ear (HP:0000378)2.13732634
26Limb dystonia (HP:0002451)2.10104286
27Pancreatic cysts (HP:0001737)2.09777369
28Protruding tongue (HP:0010808)2.09499827
29Truncal obesity (HP:0001956)2.08951607
30Absent speech (HP:0001344)2.08646053
31Vaginal atresia (HP:0000148)2.08466056
32Labial hypoplasia (HP:0000066)2.08407702
33Abnormality of salivation (HP:0100755)2.07205613
34Gait imbalance (HP:0002141)2.07152482
35Action tremor (HP:0002345)2.07018170
36Abnormality of the corticospinal tract (HP:0002492)2.04437573
37Curly hair (HP:0002212)2.04350219
38Septo-optic dysplasia (HP:0100842)2.02616151
39Amyotrophic lateral sclerosis (HP:0007354)2.01959200
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.01464765
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01464765
42Gaze-evoked nystagmus (HP:0000640)1.97932580
43Pachygyria (HP:0001302)1.95047083
44Hip dysplasia (HP:0001385)1.93245769
45Nephronophthisis (HP:0000090)1.92222319
46Specific learning disability (HP:0001328)1.91283602
47Aplasia/Hypoplasia of the sternum (HP:0006714)1.90981463
48Abnormal respiratory motile cilium morphology (HP:0005938)1.90966842
49Abnormal respiratory epithelium morphology (HP:0012253)1.90966842
50Absent/shortened dynein arms (HP:0200106)1.90513017
51Dynein arm defect of respiratory motile cilia (HP:0012255)1.90513017
52Chronic hepatic failure (HP:0100626)1.89540765
53Gonadotropin excess (HP:0000837)1.88065600
54Atonic seizures (HP:0010819)1.86655718
55Lissencephaly (HP:0001339)1.84876074
56Aplasia/Hypoplasia of the tibia (HP:0005772)1.84722831
57Dialeptic seizures (HP:0011146)1.83810559
58Abnormality of the renal medulla (HP:0100957)1.83675238
59Inappropriate behavior (HP:0000719)1.83166433
60Hypoplastic labia majora (HP:0000059)1.82777502
61Medial flaring of the eyebrow (HP:0010747)1.82307847
62Intestinal atresia (HP:0011100)1.82280247
63Neoplasm of the oral cavity (HP:0100649)1.81851011
64Epileptic encephalopathy (HP:0200134)1.81178084
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.78754302
66Short 4th metacarpal (HP:0010044)1.78754302
67Abnormality of secondary sexual hair (HP:0009888)1.77966690
68Abnormality of the axillary hair (HP:0100134)1.77966690
69Germ cell neoplasia (HP:0100728)1.77846936
70Renal hypoplasia (HP:0000089)1.77279566
71Anencephaly (HP:0002323)1.76364557
72Diastasis recti (HP:0001540)1.75554239
73Polyphagia (HP:0002591)1.74545016
74Abnormality of the labia minora (HP:0012880)1.73269523
75Hypoplastic female external genitalia (HP:0012815)1.72908494
76Vertebral arch anomaly (HP:0008438)1.71451192
77Tented upper lip vermilion (HP:0010804)1.71037138
78Poor coordination (HP:0002370)1.70698150
79Gastroesophageal reflux (HP:0002020)1.70118845
80Supernumerary ribs (HP:0005815)1.69584730
81Ankle clonus (HP:0011448)1.69282368
82Heterotopia (HP:0002282)1.68618519
83Biliary tract neoplasm (HP:0100574)1.68150256
84Hemiparesis (HP:0001269)1.67983623
85Growth hormone deficiency (HP:0000824)1.67831487
86Congenital primary aphakia (HP:0007707)1.67789326
87Abnormal ciliary motility (HP:0012262)1.67705179
88Absence seizures (HP:0002121)1.67355796
89Abnormality of the labia majora (HP:0012881)1.66307774
90Micropenis (HP:0000054)1.65166973
91Postaxial hand polydactyly (HP:0001162)1.64641080
92Blue irides (HP:0000635)1.63923298
93Cutaneous finger syndactyly (HP:0010554)1.63717645
94Obsessive-compulsive behavior (HP:0000722)1.63192530
95Tubulointerstitial nephritis (HP:0001970)1.62449372
96Dysdiadochokinesis (HP:0002075)1.62078345
97Urinary bladder sphincter dysfunction (HP:0002839)1.61481168
98Stomach cancer (HP:0012126)1.61340494
99Pheochromocytoma (HP:0002666)1.60947283
100Sporadic (HP:0003745)1.60916915

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.67760839
2MARK14.07526062
3PNCK3.08739194
4TNIK2.94171798
5TAOK12.76446935
6BCR2.54152490
7MAP3K42.52334745
8MAPK132.33882873
9SGK21.93351497
10SIK21.92720611
11BRD41.86739952
12CAMK1G1.81910427
13WNK31.77471105
14NTRK31.69687522
15MAP2K71.62842232
16SGK2231.62115413
17SGK4941.62115413
18NTRK21.60382418
19CDK191.59235813
20TAOK31.51976697
21KSR11.48613365
22YES11.47262667
23CAMK1D1.40061434
24FGFR21.38631455
25MAP2K41.34716160
26LATS11.34352487
27ACVR1B1.31407604
28EPHB21.29448626
29DYRK1B1.29150604
30DYRK31.26946466
31MKNK21.24239630
32DYRK21.23313924
33SGK31.20076027
34DYRK1A1.18304394
35TYRO31.14748777
36MAP3K21.06849207
37CDK31.05854201
38MAP3K101.05812227
39MINK11.05229747
40MARK21.00633845
41UHMK11.00041121
42FRK0.97214884
43MAPK150.96912607
44AKT30.95519395
45ERBB30.94317772
46STK38L0.93029888
47SGK10.92230525
48MKNK10.89296977
49STK390.86476176
50STK110.86311955
51EPHA30.86201679
52TRIM280.83901263
53PIK3CA0.81842498
54ERBB20.80670537
55DMPK0.79404114
56NLK0.77231976
57PRKCZ0.76195391
58PAK30.70842312
59RPS6KB10.70508930
60PRKCG0.70254518
61RPS6KA40.69420300
62WNK10.68852052
63STK240.67392075
64BRSK20.66627124
65FGFR10.65996256
66MAP3K60.65452495
67PKN10.63935794
68SRPK10.58049652
69NEK20.56401724
70CAMK10.54949091
71GRK60.53540266
72BMPR1B0.53199103
73CAMK40.52504756
74MAP3K70.50164978
75CSNK1G20.49227730
76TNK20.48964898
77CSNK1D0.47659685
78SIK30.47198456
79MAP4K20.47038571
80FGFR30.45914380
81PINK10.45364916
82PRKCH0.45215990
83NEK60.44962360
84CDK50.44718781
85PRKCE0.43510585
86PASK0.39492418
87FGR0.39390336
88PDGFRB0.39233981
89CAMKK20.38822035
90RET0.38231899
91WEE10.37911630
92MAPK100.37484765
93MATK0.37367827
94CSNK1E0.36635170
95OXSR10.36213016
96GSK3B0.35696823
97PLK20.35044256
98FER0.34709767
99STK30.33804781
100IRAK20.33402699

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11628968
2Axon guidance_Homo sapiens_hsa043602.22672157
3Steroid biosynthesis_Homo sapiens_hsa001001.97544378
4Dorso-ventral axis formation_Homo sapiens_hsa043201.91479339
5Endometrial cancer_Homo sapiens_hsa052131.79292993
6Glutamatergic synapse_Homo sapiens_hsa047241.77557695
7Colorectal cancer_Homo sapiens_hsa052101.77202474
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.60009545
9ErbB signaling pathway_Homo sapiens_hsa040121.57506719
10Dopaminergic synapse_Homo sapiens_hsa047281.54769845
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.48206166
12Renal cell carcinoma_Homo sapiens_hsa052111.46567239
13Long-term depression_Homo sapiens_hsa047301.46246175
14Cocaine addiction_Homo sapiens_hsa050301.40793502
15Adherens junction_Homo sapiens_hsa045201.39806253
16Circadian entrainment_Homo sapiens_hsa047131.37758350
17Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35453882
18Cholinergic synapse_Homo sapiens_hsa047251.35239879
19Notch signaling pathway_Homo sapiens_hsa043301.33824732
20Amphetamine addiction_Homo sapiens_hsa050311.33154143
21Long-term potentiation_Homo sapiens_hsa047201.32888210
22Fatty acid biosynthesis_Homo sapiens_hsa000611.31961134
23Basal cell carcinoma_Homo sapiens_hsa052171.31591796
24Prolactin signaling pathway_Homo sapiens_hsa049171.31438770
25Type II diabetes mellitus_Homo sapiens_hsa049301.30532279
26Taste transduction_Homo sapiens_hsa047421.29055396
27Hedgehog signaling pathway_Homo sapiens_hsa043401.26589774
28Circadian rhythm_Homo sapiens_hsa047101.24613137
29Carbohydrate digestion and absorption_Homo sapiens_hsa049731.21503578
30GABAergic synapse_Homo sapiens_hsa047271.16749025
31Morphine addiction_Homo sapiens_hsa050321.14248261
32FoxO signaling pathway_Homo sapiens_hsa040681.14160184
33Hippo signaling pathway_Homo sapiens_hsa043901.14079939
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.13411741
35Prostate cancer_Homo sapiens_hsa052151.12738530
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12657755
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12428735
38Wnt signaling pathway_Homo sapiens_hsa043101.10559406
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10234150
40Choline metabolism in cancer_Homo sapiens_hsa052311.08658674
41Insulin secretion_Homo sapiens_hsa049111.07543613
42cAMP signaling pathway_Homo sapiens_hsa040241.01758710
43Inositol phosphate metabolism_Homo sapiens_hsa005621.01291840
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99741750
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99298595
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.99271124
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99243103
48Estrogen signaling pathway_Homo sapiens_hsa049150.98516849
49TGF-beta signaling pathway_Homo sapiens_hsa043500.98371405
50Gap junction_Homo sapiens_hsa045400.98140814
51Serotonergic synapse_Homo sapiens_hsa047260.94479418
52Tight junction_Homo sapiens_hsa045300.92953007
53mTOR signaling pathway_Homo sapiens_hsa041500.91722763
54Melanogenesis_Homo sapiens_hsa049160.89815928
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.89385946
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87808901
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87041037
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.86854568
59Renin secretion_Homo sapiens_hsa049240.85891537
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.85886818
61AMPK signaling pathway_Homo sapiens_hsa041520.84313851
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84046325
63Oxytocin signaling pathway_Homo sapiens_hsa049210.81143097
64MAPK signaling pathway_Homo sapiens_hsa040100.80659184
65MicroRNAs in cancer_Homo sapiens_hsa052060.80459583
66Non-small cell lung cancer_Homo sapiens_hsa052230.80408730
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.77312512
68Ras signaling pathway_Homo sapiens_hsa040140.76138412
69Regulation of autophagy_Homo sapiens_hsa041400.75832855
70Basal transcription factors_Homo sapiens_hsa030220.72698514
71GnRH signaling pathway_Homo sapiens_hsa049120.72544314
72Acute myeloid leukemia_Homo sapiens_hsa052210.67594654
73mRNA surveillance pathway_Homo sapiens_hsa030150.65776588
74Ether lipid metabolism_Homo sapiens_hsa005650.65734189
75Rap1 signaling pathway_Homo sapiens_hsa040150.65391486
76B cell receptor signaling pathway_Homo sapiens_hsa046620.62695788
77Chronic myeloid leukemia_Homo sapiens_hsa052200.60957323
78Lysine degradation_Homo sapiens_hsa003100.60463063
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60329190
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60222541
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59891959
82Pancreatic cancer_Homo sapiens_hsa052120.59406174
83Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59382754
84Pathways in cancer_Homo sapiens_hsa052000.58516955
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58156027
86Butanoate metabolism_Homo sapiens_hsa006500.57643158
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57372986
88T cell receptor signaling pathway_Homo sapiens_hsa046600.56838751
89Thyroid cancer_Homo sapiens_hsa052160.54624037
90Insulin signaling pathway_Homo sapiens_hsa049100.52941914
91Chemokine signaling pathway_Homo sapiens_hsa040620.52808982
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52056876
93Glioma_Homo sapiens_hsa052140.51151960
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49408457
95Linoleic acid metabolism_Homo sapiens_hsa005910.49037070
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48997548
97Salivary secretion_Homo sapiens_hsa049700.48828358
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48619412
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47950697
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46103442

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