KMT5C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell migration in hindbrain (GO:0021535)4.41720157
2negative regulation of DNA-templated transcription, elongation (GO:0032785)4.19099078
3nucleosome disassembly (GO:0006337)3.97446874
4protein-DNA complex disassembly (GO:0032986)3.97446874
5negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.91035716
6positive regulation of protein kinase C signaling (GO:0090037)3.65134319
7metallo-sulfur cluster assembly (GO:0031163)3.63621592
8iron-sulfur cluster assembly (GO:0016226)3.63621592
9behavioral response to nicotine (GO:0035095)3.54616403
10positive regulation by host of viral transcription (GO:0043923)3.45443603
11positive regulation of histone deacetylation (GO:0031065)3.45107317
12negative regulation of telomere maintenance (GO:0032205)3.35452265
13regulation of hydrogen peroxide metabolic process (GO:0010310)3.32304765
14peptidyl-arginine omega-N-methylation (GO:0035247)3.22030527
15intracellular estrogen receptor signaling pathway (GO:0030520)3.20402364
16negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.16685364
17establishment of mitochondrion localization (GO:0051654)3.16430788
18phosphatidylglycerol biosynthetic process (GO:0006655)3.14889595
19establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.14272766
20mitochondrion transport along microtubule (GO:0047497)3.14272766
21regulation of chromatin binding (GO:0035561)3.13303778
22protein polyglutamylation (GO:0018095)3.10088822
23histone H3 deacetylation (GO:0070932)3.09284662
24motile cilium assembly (GO:0044458)3.06427775
25regulation of histone H3-K4 methylation (GO:0051569)3.05581391
26histone H4 deacetylation (GO:0070933)3.01783597
27negative regulation of T cell differentiation in thymus (GO:0033085)2.98295069
28histone H3-K9 methylation (GO:0051567)2.92304723
29regulation of nuclear cell cycle DNA replication (GO:0033262)2.92047301
30negative regulation of telomerase activity (GO:0051974)2.91932422
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.91558467
32positive regulation of T cell apoptotic process (GO:0070234)2.91255345
33ncRNA 3-end processing (GO:0043628)2.90630485
34protein insertion into membrane (GO:0051205)2.90556055
35DNA methylation (GO:0006306)2.89501156
36DNA alkylation (GO:0006305)2.89501156
37viral transcription (GO:0019083)2.86893353
38chromatin assembly (GO:0031497)2.85541117
39regulation of telomerase activity (GO:0051972)2.85004102
40snRNA metabolic process (GO:0016073)2.83354718
41peptidyl-arginine methylation (GO:0018216)2.83102318
42peptidyl-arginine N-methylation (GO:0035246)2.83102318
43cornea development in camera-type eye (GO:0061303)2.80415267
44snRNA processing (GO:0016180)2.78782725
45ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.73901294
46apoptotic process involved in morphogenesis (GO:0060561)2.73691489
47establishment or maintenance of monopolar cell polarity (GO:0061339)2.73403035
48establishment of monopolar cell polarity (GO:0061162)2.73403035
49misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.71451549
50tRNA modification (GO:0006400)2.69036574
51histone arginine methylation (GO:0034969)2.68848979
52positive regulation of lymphocyte apoptotic process (GO:0070230)2.68196989
53base-excision repair, AP site formation (GO:0006285)2.67361495
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.66821510
55translational elongation (GO:0006414)2.66696360
56meiotic chromosome segregation (GO:0045132)2.66517862
57response to misfolded protein (GO:0051788)2.64709420
58histone H3-K9 modification (GO:0061647)2.64372043
59negative regulation of cell size (GO:0045792)2.63103294
60positive regulation of mitochondrial membrane permeability (GO:0035794)2.63026499
61ribosomal small subunit biogenesis (GO:0042274)2.62441802
62head development (GO:0060322)2.61841332
63mucosal-associated lymphoid tissue development (GO:0048537)2.61785376
64Peyers patch development (GO:0048541)2.61785376
65positive regulation of protein homooligomerization (GO:0032464)2.60759133
66translational termination (GO:0006415)2.60679163
67sulfate transmembrane transport (GO:1902358)2.60350990
68axoneme assembly (GO:0035082)2.60103895
69DNA deamination (GO:0045006)2.59864846
70cell proliferation in forebrain (GO:0021846)2.59462917
71positive regulation of gene expression, epigenetic (GO:0045815)2.58366796
72post-embryonic morphogenesis (GO:0009886)2.55581876
73positive regulation of CREB transcription factor activity (GO:0032793)2.55554117
74negative regulation of gene expression, epigenetic (GO:0045814)2.55521985
75spinal cord association neuron differentiation (GO:0021527)2.55454405
76mRNA splice site selection (GO:0006376)2.55367122
77positive regulation of protein deacetylation (GO:0090312)2.55308251
78convergent extension (GO:0060026)2.52923954
79positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.52386344
80mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.52386344
81sulfate transport (GO:0008272)2.51520418
82modulation by host of viral transcription (GO:0043921)2.49744869
83modulation by host of symbiont transcription (GO:0052472)2.49744869
84pyrimidine nucleotide catabolic process (GO:0006244)2.48287481
85snRNA transcription (GO:0009301)2.48168337
86dorsal/ventral neural tube patterning (GO:0021904)2.48030088
87DNA damage induced protein phosphorylation (GO:0006975)2.46634012
88chromatin silencing (GO:0006342)2.46588611
89ribosomal small subunit assembly (GO:0000028)2.45417429
90apoptotic process involved in development (GO:1902742)2.44850582
91regulation of histone deacetylation (GO:0031063)2.44009186
92preassembly of GPI anchor in ER membrane (GO:0016254)2.43227880
93heterochromatin organization (GO:0070828)2.43209612
94dosage compensation (GO:0007549)2.42014481
95lung epithelium development (GO:0060428)2.41796923
96protein complex disassembly (GO:0043241)2.40823061
97establishment of apical/basal cell polarity (GO:0035089)2.39435153
98DNA methylation or demethylation (GO:0044728)2.38656159
99negative regulation of cAMP-mediated signaling (GO:0043951)2.38599989
100negative regulation of mRNA processing (GO:0050686)2.37765627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.44451180
2CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.62964866
3VDR_21846776_ChIP-Seq_THP-1_Human2.55922126
4P68_20966046_ChIP-Seq_HELA_Human2.54513632
5LXR_22292898_ChIP-Seq_THP-1_Human2.45553221
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44876731
7MYC_22102868_ChIP-Seq_BL_Human2.39456650
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25896457
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.13940307
10ELF1_20517297_ChIP-Seq_JURKAT_Human2.07839365
11ERG_21242973_ChIP-ChIP_JURKAT_Human1.94040018
12TET1_21451524_ChIP-Seq_MESCs_Mouse1.93123553
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91129975
14XRN2_22483619_ChIP-Seq_HELA_Human1.84830685
15BCL6_27268052_Chip-Seq_Bcells_Human1.84546974
16PHF8_20622854_ChIP-Seq_HELA_Human1.84448753
17CTCF_27219007_Chip-Seq_Bcells_Human1.81284032
18KDM2B_26808549_Chip-Seq_DND41_Human1.78122201
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77671340
20EZH2_22144423_ChIP-Seq_EOC_Human1.76469241
21BCOR_27268052_Chip-Seq_Bcells_Human1.72574610
22SA1_27219007_Chip-Seq_ERYTHROID_Human1.69981040
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69385683
24E2F1_20622854_ChIP-Seq_HELA_Human1.68547811
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66478714
26CIITA_25753668_ChIP-Seq_RAJI_Human1.66014231
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62902827
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61323093
29FOXP1_21924763_ChIP-Seq_HESCs_Human1.60277975
30SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59974616
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58069894
32SMC4_20622854_ChIP-Seq_HELA_Human1.57800711
33GABP_19822575_ChIP-Seq_HepG2_Human1.55771275
34MAF_26560356_Chip-Seq_TH2_Human1.55611053
35SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53592662
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.52777016
37CREB1_26743006_Chip-Seq_LNCaP_Human1.52574315
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52516177
39RACK7_27058665_Chip-Seq_MCF-7_Human1.51808360
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50831775
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50798807
42CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47666936
43EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.47330434
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47126541
45KDM5A_27292631_Chip-Seq_BREAST_Human1.45974091
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.45465444
47MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.44900854
48SA1_27219007_Chip-Seq_Bcells_Human1.44603543
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.41793092
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41667052
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41334007
52RARB_24833708_ChIP-Seq_LIVER_Mouse1.40653190
53KDM2B_26808549_Chip-Seq_K562_Human1.40164933
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38930444
55RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.37828490
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.37459169
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37357701
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.36120308
59ERA_21632823_ChIP-Seq_H3396_Human1.35345162
60CTCF_20526341_ChIP-Seq_ESCs_Human1.35127529
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.35011406
62NCOR1_26117541_ChIP-Seq_K562_Human1.32377601
63RARA_24833708_ChIP-Seq_LIVER_Mouse1.31578534
64CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30412390
65CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29739908
66UTX_26944678_Chip-Seq_JUKART_Human1.29213703
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28885117
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26930164
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26388125
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25152099
71TCF7_22412390_ChIP-Seq_EML_Mouse1.24898790
72OCT4_19829295_ChIP-Seq_ESCs_Human1.23623877
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21902450
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20481709
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.20464137
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.19619801
77DROSHA_22980978_ChIP-Seq_HELA_Human1.18526340
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18079010
79CTCF_21964334_Chip-Seq_Bcells_Human1.17544940
80TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.17112083
81TTF2_22483619_ChIP-Seq_HELA_Human1.16660978
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15179800
83PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14945108
84SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.14684926
85P300_27268052_Chip-Seq_Bcells_Human1.13352394
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.13228326
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12142590
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11145460
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10468824
90MAF_26560356_Chip-Seq_TH1_Human1.10160311
91TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09103050
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.07556572
93HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07403017
94SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06991664
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.06515214
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.05297224
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05025101
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04348402
99RAC3_21632823_ChIP-Seq_H3396_Human1.03838931
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03550547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.31479827
2MP0002653_abnormal_ependyma_morphology3.27287347
3MP0002249_abnormal_larynx_morphology2.87199282
4MP0003136_yellow_coat_color2.64323678
5MP0008995_early_reproductive_senescence2.61031475
6MP0000678_abnormal_parathyroid_gland2.48722055
7MP0003787_abnormal_imprinting2.37634804
8MP0004133_heterotaxia2.35549175
9MP0005377_hearing/vestibular/ear_phenot2.35048145
10MP0003878_abnormal_ear_physiology2.35048145
11MP0002163_abnormal_gland_morphology2.30755906
12MP0005394_taste/olfaction_phenotype2.21993770
13MP0005499_abnormal_olfactory_system2.21993770
14MP0008789_abnormal_olfactory_epithelium2.21957105
15MP0005645_abnormal_hypothalamus_physiol2.20570094
16MP0002234_abnormal_pharynx_morphology2.11592327
17MP0009278_abnormal_bone_marrow2.07676524
18MP0004147_increased_porphyrin_level2.02464136
19MP0002822_catalepsy1.99832639
20MP0001873_stomach_inflammation1.98800590
21MP0000049_abnormal_middle_ear1.98055383
22MP0000566_synostosis1.87715110
23MP0001348_abnormal_lacrimal_gland1.75980659
24MP0005083_abnormal_biliary_tract1.63348957
25MP0003693_abnormal_embryo_hatching1.60992207
26MP0001188_hyperpigmentation1.60196851
27MP0001529_abnormal_vocalization1.58750854
28MP0000631_abnormal_neuroendocrine_gland1.56592901
29MP0001502_abnormal_circadian_rhythm1.48335762
30MP0002254_reproductive_system_inflammat1.45128354
31MP0004381_abnormal_hair_follicle1.38772403
32MP0003122_maternal_imprinting1.32546553
33MP0003938_abnormal_ear_development1.31654242
34MP0005646_abnormal_pituitary_gland1.30895675
35MP0003283_abnormal_digestive_organ1.22755643
36MP0006276_abnormal_autonomic_nervous1.18745178
37MP0003786_premature_aging1.18293192
38MP0003111_abnormal_nucleus_morphology1.17387358
39MP0001968_abnormal_touch/_nociception1.16734609
40MP0003119_abnormal_digestive_system1.15453234
41MP0001919_abnormal_reproductive_system1.11900381
42MP0003861_abnormal_nervous_system1.11547327
43MP0008877_abnormal_DNA_methylation1.08798933
44MP0010030_abnormal_orbit_morphology1.07395789
45MP0003942_abnormal_urinary_system1.06235674
46MP0008875_abnormal_xenobiotic_pharmacok1.05482693
47MP0001485_abnormal_pinna_reflex1.03824145
48MP0001293_anophthalmia1.03256782
49MP0004858_abnormal_nervous_system1.02694748
50MP0002210_abnormal_sex_determination1.02272863
51MP0000026_abnormal_inner_ear1.01683825
52MP0001346_abnormal_lacrimal_gland1.00886992
53MP0009333_abnormal_splenocyte_physiolog1.00693724
54MP0002557_abnormal_social/conspecific_i0.99552874
55MP0005379_endocrine/exocrine_gland_phen0.97622994
56MP0003698_abnormal_male_reproductive0.96258816
57MP0005076_abnormal_cell_differentiation0.96093805
58MP0003121_genomic_imprinting0.94883274
59MP0002752_abnormal_somatic_nervous0.94423644
60MP0003123_paternal_imprinting0.92844620
61MP0000778_abnormal_nervous_system0.92560741
62MP0008872_abnormal_physiological_respon0.92491584
63MP0002932_abnormal_joint_morphology0.89397014
64MP0005451_abnormal_body_composition0.89132242
65MP0002733_abnormal_thermal_nociception0.86733110
66MP0000955_abnormal_spinal_cord0.86488544
67MP0002116_abnormal_craniofacial_bone0.86443903
68MP0002735_abnormal_chemical_nociception0.86175235
69MP0005423_abnormal_somatic_nervous0.85200952
70MP0000703_abnormal_thymus_morphology0.84037799
71MP0004742_abnormal_vestibular_system0.83751699
72MP0002160_abnormal_reproductive_system0.82720754
73MP0002751_abnormal_autonomic_nervous0.81753324
74MP0005220_abnormal_exocrine_pancreas0.81362760
75MP0002152_abnormal_brain_morphology0.80508611
76MP0001270_distended_abdomen0.78847576
77MP0001145_abnormal_male_reproductive0.78742413
78MP0008961_abnormal_basal_metabolism0.78152070
79MP0005075_abnormal_melanosome_morpholog0.77963998
80MP0001929_abnormal_gametogenesis0.77778553
81MP0000470_abnormal_stomach_morphology0.76965292
82MP0002184_abnormal_innervation0.75330058
83MP0008058_abnormal_DNA_repair0.75120567
84MP0002882_abnormal_neuron_morphology0.73618823
85MP0009379_abnormal_foot_pigmentation0.73127686
86MP0002089_abnormal_postnatal_growth/wei0.71616504
87MP0001970_abnormal_pain_threshold0.71199224
88MP0005389_reproductive_system_phenotype0.71168872
89MP0002063_abnormal_learning/memory/cond0.71119342
90MP0001963_abnormal_hearing_physiology0.71025435
91MP0004145_abnormal_muscle_electrophysio0.70630673
92MP0001849_ear_inflammation0.69906620
93MP0005551_abnormal_eye_electrophysiolog0.68284928
94MP0000681_abnormal_thyroid_gland0.67349840
95MP0002277_abnormal_respiratory_mucosa0.67190255
96MP0002111_abnormal_tail_morphology0.66522106
97MP0005671_abnormal_response_to0.66492516
98MP0000653_abnormal_sex_gland0.66270619
99MP0002572_abnormal_emotion/affect_behav0.64921381
100MP0001764_abnormal_homeostasis0.63996410

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the aortic arch (HP:0012303)4.19778933
2Broad distal phalanx of finger (HP:0009836)3.68081035
3Rib fusion (HP:0000902)3.26665243
4Hyperthyroidism (HP:0000836)3.15101331
5Patellar aplasia (HP:0006443)3.14768076
6Truncus arteriosus (HP:0001660)3.07656960
7Aplasia/Hypoplasia of the patella (HP:0006498)3.05852034
8Abnormality of DNA repair (HP:0003254)2.97155271
9Molar tooth sign on MRI (HP:0002419)2.78177411
10Abnormality of midbrain morphology (HP:0002418)2.78177411
11Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77830737
12Type II lissencephaly (HP:0007260)2.77794365
13Reticulocytopenia (HP:0001896)2.77290595
14Concave nail (HP:0001598)2.71564415
15Abnormal number of erythroid precursors (HP:0012131)2.67851607
16Optic nerve coloboma (HP:0000588)2.66248342
17Abnormality of cells of the erythroid lineage (HP:0012130)2.56445030
18Abnormality of reticulocytes (HP:0004312)2.53843084
19Nephronophthisis (HP:0000090)2.50338620
20Cerebellar dysplasia (HP:0007033)2.47222067
21Cystic liver disease (HP:0006706)2.44658648
22Reticulocytosis (HP:0001923)2.42736368
23Occipital encephalocele (HP:0002085)2.42067510
24Retinal dysplasia (HP:0007973)2.40698389
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.35198527
26Chronic hepatic failure (HP:0100626)2.33431854
27Sclerocornea (HP:0000647)2.32459552
28Absent thumb (HP:0009777)2.31378374
29Testicular atrophy (HP:0000029)2.26058901
30Septate vagina (HP:0001153)2.23699990
31High anterior hairline (HP:0009890)2.23466302
32Microretrognathia (HP:0000308)2.16054119
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.14768947
34Horseshoe kidney (HP:0000085)2.14445736
35Asplenia (HP:0001746)2.12974495
36Seborrheic dermatitis (HP:0001051)2.11057762
37Renal dysplasia (HP:0000110)2.10067536
38Mesangial abnormality (HP:0001966)2.06857521
39Stridor (HP:0010307)2.06241328
40Pancreatic cysts (HP:0001737)2.05552164
41Pancreatic fibrosis (HP:0100732)2.00409724
42Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98630453
43Severe muscular hypotonia (HP:0006829)1.96214921
44Hypoparathyroidism (HP:0000829)1.96111294
45Deep palmar crease (HP:0006191)1.95907991
46J-shaped sella turcica (HP:0002680)1.95874016
47Atelectasis (HP:0100750)1.95238353
48Pendular nystagmus (HP:0012043)1.94763286
49Absent epiphyses (HP:0010577)1.94487186
50Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.94487186
51Anencephaly (HP:0002323)1.92847775
52Squamous cell carcinoma (HP:0002860)1.90460266
53Congenital stationary night blindness (HP:0007642)1.90065157
54Duplicated collecting system (HP:0000081)1.89809479
55Flat capital femoral epiphysis (HP:0003370)1.85933443
56Bile duct proliferation (HP:0001408)1.85647571
57Abnormal biliary tract physiology (HP:0012439)1.85647571
58Hyperacusis (HP:0010780)1.85222334
59True hermaphroditism (HP:0010459)1.83839682
60Abnormality of the renal collecting system (HP:0004742)1.82106811
61Abnormality of homocysteine metabolism (HP:0010919)1.82060334
62Homocystinuria (HP:0002156)1.82060334
63Abnormality of the renal medulla (HP:0100957)1.81808063
64Ectopic kidney (HP:0000086)1.81342797
65Abnormal rod and cone electroretinograms (HP:0008323)1.79728478
66Poikiloderma (HP:0001029)1.79643325
67Attenuation of retinal blood vessels (HP:0007843)1.79520034
68Abnormality of the parathyroid morphology (HP:0011766)1.79227898
69Lissencephaly (HP:0001339)1.78477596
70Abnormality of the intervertebral disk (HP:0005108)1.78373320
71Genetic anticipation (HP:0003743)1.78079914
72Breast hypoplasia (HP:0003187)1.76673571
73Visual hallucinations (HP:0002367)1.74895222
74Easy fatigability (HP:0003388)1.74555278
75Cerebral palsy (HP:0100021)1.73044911
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71123219
7711 pairs of ribs (HP:0000878)1.70909636
78Abnormal number of incisors (HP:0011064)1.70904220
79Hypertensive crisis (HP:0100735)1.69583636
80Amblyopia (HP:0000646)1.67549940
81Short thumb (HP:0009778)1.66855924
82Birth length less than 3rd percentile (HP:0003561)1.64459027
83Preaxial hand polydactyly (HP:0001177)1.63665263
84Broad phalanges of the hand (HP:0009768)1.63405314
85Intestinal fistula (HP:0100819)1.62865999
86Abnormality of the fingertips (HP:0001211)1.61755875
87Abnormality of cochlea (HP:0000375)1.60738403
88Impulsivity (HP:0100710)1.60697525
89Polymicrogyria (HP:0002126)1.59257288
90Progressive microcephaly (HP:0000253)1.57871991
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57428752
92Rectal prolapse (HP:0002035)1.56602308
93Postaxial foot polydactyly (HP:0001830)1.55743824
94Holoprosencephaly (HP:0001360)1.55153430
95Abnormal gallbladder physiology (HP:0012438)1.54967012
96Cholecystitis (HP:0001082)1.54967012
97Esophageal atresia (HP:0002032)1.52753468
98Absent radius (HP:0003974)1.52508808
99Slender long bone (HP:0003100)1.52396357
100Pointed chin (HP:0000307)1.52076789

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.62344130
2SIK13.26418065
3EEF2K3.20563089
4TLK12.97697899
5SIK22.80974899
6BCKDK2.52289477
7WNK42.29240321
8MAPK152.25355720
9SMG12.05891498
10MAP2K62.02799713
11ICK1.93326560
12KDR1.86113444
13NME11.78809938
14TNK21.75946876
15ZAK1.75213987
16CDK121.66111818
17MAP3K101.65590266
18MAP4K11.62360545
19MAP2K21.60789774
20MUSK1.57347826
21MAP3K111.56173438
22TYRO31.49054564
23MARK21.42637085
24MAP4K21.30532199
25CAMK1D1.23058039
26RPS6KA61.21855551
27RPS6KA21.20754805
28DYRK21.20381233
29TAOK21.18577835
30RPS6KC11.17225655
31RPS6KL11.17225655
32PRKCI1.15003344
33CAMKK11.13475715
34PKN21.12094752
35GRK61.10410417
36PRKD21.08362461
37MAP3K71.08047573
38MAPKAPK31.03453890
39TESK21.03294151
40HIPK21.01803708
41ATR0.98797553
42ADRBK20.97553495
43RPS6KB20.95999277
44SIK30.94910733
45PASK0.93735640
46DYRK30.90256824
47MTOR0.86899432
48CDK70.85689652
49CHUK0.83864821
50BMX0.83313597
51ITK0.79824891
52NTRK30.79790205
53EPHA20.79311902
54DYRK1B0.78522300
55CHEK20.77384459
56RPS6KA10.76552920
57RPS6KA50.75832021
58IKBKB0.72926944
59AURKA0.72001893
60PRKAA10.71780346
61TXK0.70718655
62NEK20.68782811
63BRAF0.65815392
64IRAK30.65054273
65MAPK110.64902630
66PRKD30.64853018
67VRK20.64734180
68PTK60.64339417
69STK110.63851286
70CDC70.62872874
71FGFR20.62565443
72CDK40.61087587
73MAP2K40.61015225
74DAPK20.58921516
75CAMK40.58626080
76MAP2K70.58306050
77PRKCH0.57897892
78BRD40.56460402
79CSNK1G30.55372435
80CDK20.53712436
81CDK190.53539184
82GRK10.52883271
83MAPK80.51934875
84PRKCZ0.51745997
85AKT10.49196802
86MAPK130.48011463
87BTK0.47658972
88MAP3K60.46251063
89MARK30.46236089
90STK160.45848469
91FGFR40.45411925
92MAP3K40.45339758
93IRAK40.44613753
94MAPKAPK50.43755536
95NME20.43054561
96ERBB20.42627910
97CDK10.42113791
98CSNK1A1L0.41976752
99CHEK10.41476653
100CDK80.40953843

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.24756101
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.19192172
3Notch signaling pathway_Homo sapiens_hsa043303.12781100
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.97246365
5Ribosome_Homo sapiens_hsa030102.96202194
6Base excision repair_Homo sapiens_hsa034102.60850389
7RNA polymerase_Homo sapiens_hsa030202.31697970
8Fanconi anemia pathway_Homo sapiens_hsa034602.18376280
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.12778596
10Basal cell carcinoma_Homo sapiens_hsa052172.01274350
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00654877
12Primary immunodeficiency_Homo sapiens_hsa053401.96653523
13Spliceosome_Homo sapiens_hsa030401.92654780
14Phototransduction_Homo sapiens_hsa047441.85761328
15Homologous recombination_Homo sapiens_hsa034401.83812233
16Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81225047
17Selenocompound metabolism_Homo sapiens_hsa004501.74633330
18Linoleic acid metabolism_Homo sapiens_hsa005911.72696819
19Lysine degradation_Homo sapiens_hsa003101.70461121
20One carbon pool by folate_Homo sapiens_hsa006701.62228578
21mRNA surveillance pathway_Homo sapiens_hsa030151.52980766
22VEGF signaling pathway_Homo sapiens_hsa043701.49663695
23Pyrimidine metabolism_Homo sapiens_hsa002401.49662791
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42319602
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41589510
26Ether lipid metabolism_Homo sapiens_hsa005651.38718409
27DNA replication_Homo sapiens_hsa030301.38697243
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38604754
29Oxidative phosphorylation_Homo sapiens_hsa001901.38054656
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.33728320
31ABC transporters_Homo sapiens_hsa020101.33502995
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.23764996
33Alcoholism_Homo sapiens_hsa050341.23011037
34Hedgehog signaling pathway_Homo sapiens_hsa043401.20121734
35Huntingtons disease_Homo sapiens_hsa050161.19168086
36Acute myeloid leukemia_Homo sapiens_hsa052211.19056158
37RNA transport_Homo sapiens_hsa030131.13963866
38T cell receptor signaling pathway_Homo sapiens_hsa046601.13344333
39RNA degradation_Homo sapiens_hsa030181.10221879
40Biosynthesis of amino acids_Homo sapiens_hsa012301.08874642
41Basal transcription factors_Homo sapiens_hsa030221.07754391
42Parkinsons disease_Homo sapiens_hsa050121.05902419
43Other glycan degradation_Homo sapiens_hsa005111.01274655
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98135149
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97805934
46mTOR signaling pathway_Homo sapiens_hsa041500.89939883
47Purine metabolism_Homo sapiens_hsa002300.89680966
48AMPK signaling pathway_Homo sapiens_hsa041520.88857908
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.88580796
50Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87956525
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84767042
52Nucleotide excision repair_Homo sapiens_hsa034200.84403109
53Fructose and mannose metabolism_Homo sapiens_hsa000510.83069467
54Caffeine metabolism_Homo sapiens_hsa002320.82785928
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81878342
56Hippo signaling pathway_Homo sapiens_hsa043900.81587354
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78208268
58Choline metabolism in cancer_Homo sapiens_hsa052310.73932919
59Axon guidance_Homo sapiens_hsa043600.72471232
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68986439
61Regulation of autophagy_Homo sapiens_hsa041400.68886843
62Bladder cancer_Homo sapiens_hsa052190.65764250
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64264919
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.57342731
65Taste transduction_Homo sapiens_hsa047420.57040469
66Metabolic pathways_Homo sapiens_hsa011000.56027946
67Systemic lupus erythematosus_Homo sapiens_hsa053220.53791630
68Cardiac muscle contraction_Homo sapiens_hsa042600.53774357
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52355868
70Insulin signaling pathway_Homo sapiens_hsa049100.52277871
71Collecting duct acid secretion_Homo sapiens_hsa049660.51293493
72Non-small cell lung cancer_Homo sapiens_hsa052230.50684295
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48218178
74Melanogenesis_Homo sapiens_hsa049160.48082483
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47944363
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46987980
77Inositol phosphate metabolism_Homo sapiens_hsa005620.46389963
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45267957
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.45152638
80Nicotine addiction_Homo sapiens_hsa050330.44825247
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44787168
82Nitrogen metabolism_Homo sapiens_hsa009100.44201551
83Ovarian steroidogenesis_Homo sapiens_hsa049130.43099992
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40790370
85Wnt signaling pathway_Homo sapiens_hsa043100.39461949
86Olfactory transduction_Homo sapiens_hsa047400.39445438
87Pentose phosphate pathway_Homo sapiens_hsa000300.38650802
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38185923
89Type II diabetes mellitus_Homo sapiens_hsa049300.38146152
90Butanoate metabolism_Homo sapiens_hsa006500.37378796
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36952208
92Morphine addiction_Homo sapiens_hsa050320.35635798
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.35014850
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.34836495
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34455948
96Epstein-Barr virus infection_Homo sapiens_hsa051690.34167125
97ErbB signaling pathway_Homo sapiens_hsa040120.33606349
98Peroxisome_Homo sapiens_hsa041460.32422392
99Steroid biosynthesis_Homo sapiens_hsa001000.32363503
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.32284037

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