KNG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.76113626
2epoxygenase P450 pathway (GO:0019373)7.74324440
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.57851029
4L-phenylalanine catabolic process (GO:0006559)7.57851029
5omega-hydroxylase P450 pathway (GO:0097267)7.43290894
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.24917859
7L-phenylalanine metabolic process (GO:0006558)7.24917859
8aromatic amino acid family catabolic process (GO:0009074)6.76283313
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.51266755
10tryptophan catabolic process (GO:0006569)6.05775837
11indole-containing compound catabolic process (GO:0042436)6.05775837
12indolalkylamine catabolic process (GO:0046218)6.05775837
13drug metabolic process (GO:0017144)6.04140921
14oxidative demethylation (GO:0070989)5.98415638
15kynurenine metabolic process (GO:0070189)5.95766371
16bile acid biosynthetic process (GO:0006699)5.86870013
17negative regulation of fibrinolysis (GO:0051918)5.86669592
18glyoxylate metabolic process (GO:0046487)5.83217362
19high-density lipoprotein particle remodeling (GO:0034375)5.77939652
20urea metabolic process (GO:0019627)5.73765791
21urea cycle (GO:0000050)5.73765791
22tryptophan metabolic process (GO:0006568)5.71258236
23regulation of fibrinolysis (GO:0051917)5.63357043
24phenylpropanoid metabolic process (GO:0009698)5.55854864
25alpha-linolenic acid metabolic process (GO:0036109)5.52698321
26protein carboxylation (GO:0018214)5.45193087
27peptidyl-glutamic acid carboxylation (GO:0017187)5.45193087
28regulation of protein activation cascade (GO:2000257)5.42280273
29cysteine metabolic process (GO:0006534)5.36087104
30sulfur amino acid catabolic process (GO:0000098)5.35815540
31complement activation, alternative pathway (GO:0006957)5.35054437
32nitrogen cycle metabolic process (GO:0071941)5.27072555
33regulation of plasminogen activation (GO:0010755)5.16383328
34serine family amino acid catabolic process (GO:0009071)5.12926541
35reverse cholesterol transport (GO:0043691)5.10606407
36regulation of cholesterol esterification (GO:0010872)5.07494908
37bile acid metabolic process (GO:0008206)5.04076534
38regulation of complement activation (GO:0030449)5.03253288
39plasma lipoprotein particle remodeling (GO:0034369)4.97778363
40protein-lipid complex remodeling (GO:0034368)4.97778363
41macromolecular complex remodeling (GO:0034367)4.97778363
42regulation of triglyceride catabolic process (GO:0010896)4.94421173
43aromatic amino acid family metabolic process (GO:0009072)4.92060400
44ethanol metabolic process (GO:0006067)4.84259257
45tyrosine metabolic process (GO:0006570)4.82578405
46homocysteine metabolic process (GO:0050667)4.78730126
47fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.78111301
48phospholipid efflux (GO:0033700)4.75126798
49acylglycerol homeostasis (GO:0055090)4.70088768
50triglyceride homeostasis (GO:0070328)4.70088768
51response to mercury ion (GO:0046689)4.68395319
52S-adenosylmethionine metabolic process (GO:0046500)4.67195092
53* negative regulation of hemostasis (GO:1900047)4.66228505
54* negative regulation of blood coagulation (GO:0030195)4.66228505
55alpha-amino acid catabolic process (GO:1901606)4.62244955
56alkaloid metabolic process (GO:0009820)4.60789107
57negative regulation of cholesterol transport (GO:0032375)4.60757782
58negative regulation of sterol transport (GO:0032372)4.60757782
59amino-acid betaine metabolic process (GO:0006577)4.58589111
60plasma lipoprotein particle clearance (GO:0034381)4.57530386
61lysine metabolic process (GO:0006553)4.51829898
62lysine catabolic process (GO:0006554)4.51829898
63cellular ketone body metabolic process (GO:0046950)4.44542899
64glycine metabolic process (GO:0006544)4.42918137
65cholesterol efflux (GO:0033344)4.38336711
66regulation of humoral immune response (GO:0002920)4.36643821
67bile acid and bile salt transport (GO:0015721)4.36387542
68hormone catabolic process (GO:0042447)4.32990652
69imidazole-containing compound metabolic process (GO:0052803)4.31514649
70indolalkylamine metabolic process (GO:0006586)4.29545580
71coenzyme catabolic process (GO:0009109)4.26592193
72positive regulation of blood coagulation (GO:0030194)4.25784218
73positive regulation of hemostasis (GO:1900048)4.25784218
74cellular amino acid catabolic process (GO:0009063)4.24946616
75glutamate metabolic process (GO:0006536)4.24772660
76* negative regulation of coagulation (GO:0050819)4.23152128
77* negative regulation of wound healing (GO:0061045)4.21969344
78amine catabolic process (GO:0009310)4.20198567
79cellular biogenic amine catabolic process (GO:0042402)4.20198567
80plasma lipoprotein particle assembly (GO:0034377)4.19036893
81serine family amino acid metabolic process (GO:0009069)4.17509351
82cellular glucuronidation (GO:0052695)4.16841058
83fibrinolysis (GO:0042730)4.14539190
84low-density lipoprotein particle remodeling (GO:0034374)4.12649783
85arginine metabolic process (GO:0006525)4.07233320
86benzene-containing compound metabolic process (GO:0042537)4.06289902
87cellular modified amino acid catabolic process (GO:0042219)4.06206346
88serine family amino acid biosynthetic process (GO:0009070)4.04147297
89aldehyde catabolic process (GO:0046185)4.03796533
90dicarboxylic acid biosynthetic process (GO:0043650)4.02875949
91ethanol oxidation (GO:0006069)3.97098894
92aminoglycoside antibiotic metabolic process (GO:0030647)3.96735265
93flavonoid metabolic process (GO:0009812)3.95802635
94drug catabolic process (GO:0042737)3.93385076
95positive regulation of lipoprotein lipase activity (GO:0051006)3.92942435
96positive regulation of triglyceride lipase activity (GO:0061365)3.92942435
97positive regulation of coagulation (GO:0050820)3.92663144
98polyketide metabolic process (GO:0030638)3.91198212
99doxorubicin metabolic process (GO:0044598)3.91198212
100daunorubicin metabolic process (GO:0044597)3.91198212
101phospholipid homeostasis (GO:0055091)3.85961858
102ketone body metabolic process (GO:1902224)3.84741188
103negative regulation of lipase activity (GO:0060192)3.84366523
104fat-soluble vitamin biosynthetic process (GO:0042362)3.83112845
105positive regulation of lipid catabolic process (GO:0050996)3.81719662
106cholesterol homeostasis (GO:0042632)3.81264315
107very-low-density lipoprotein particle assembly (GO:0034379)3.80427511
108cofactor catabolic process (GO:0051187)3.79201918
109plasma lipoprotein particle organization (GO:0071827)3.78876580
110regulation of lipoprotein particle clearance (GO:0010984)3.77609972
111protein-lipid complex assembly (GO:0065005)3.75600938
112complement activation, classical pathway (GO:0006958)3.75325845
113sterol homeostasis (GO:0055092)3.74861895
114steroid catabolic process (GO:0006706)3.73670685
115complement activation (GO:0006956)3.73457797
116carboxylic acid catabolic process (GO:0046395)3.71164048
117organic acid catabolic process (GO:0016054)3.71164048
118cytolysis (GO:0019835)3.70170729
119intestinal cholesterol absorption (GO:0030299)3.69769998
120uronic acid metabolic process (GO:0006063)3.69408629
121glucuronate metabolic process (GO:0019585)3.69408629
122* protein activation cascade (GO:0072376)3.67357550
123* blood coagulation, intrinsic pathway (GO:0007597)3.66412792
124regulation of bile acid biosynthetic process (GO:0070857)3.66021452
125acute-phase response (GO:0006953)3.64999558
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.61259808
127regulation of cholesterol homeostasis (GO:2000188)3.59432748
128short-chain fatty acid metabolic process (GO:0046459)3.59178375
129negative regulation of protein activation cascade (GO:2000258)3.58960443
130sodium-independent organic anion transport (GO:0043252)3.58799795
131acetyl-CoA metabolic process (GO:0006084)3.58471741
132xenobiotic metabolic process (GO:0006805)3.57515115
133heme transport (GO:0015886)3.57183328
134negative regulation of complement activation (GO:0045916)3.56715398
135primary alcohol catabolic process (GO:0034310)3.55162801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.41031128
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21649923
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98669415
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.52957658
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33457127
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.16518772
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89180271
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.09181947
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.05015186
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08537561
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02464762
12* ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0350413
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96815468
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.62311354
15CLOCK_20551151_ChIP-Seq_293T_Human1.58721565
16HTT_18923047_ChIP-ChIP_STHdh_Human1.55560998
17GATA1_22025678_ChIP-Seq_K562_Human1.49622423
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40825672
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34194719
20TRIM28_21343339_ChIP-Seq_HEK293_Human1.21637942
21ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18550639
22* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17929483
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17473030
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17303554
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02513152
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.02160245
27CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.99856875
28ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99415084
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98188098
30HNFA_21074721_ChIP-Seq_CACO-2_Human0.97404931
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92144388
32PHF8_20622853_ChIP-Seq_HELA_Human0.91459337
33SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90522216
34PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87160199
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86565497
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86268962
37GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.85925565
38IRF1_19129219_ChIP-ChIP_H3396_Human0.85141688
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84141028
40IRF8_22096565_ChIP-ChIP_GC-B_Human0.84138827
41EZH2_27294783_Chip-Seq_NPCs_Mouse0.84058156
42RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83316991
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81700380
44NFYA_21822215_ChIP-Seq_K562_Human0.81419393
45GATA4_25053715_ChIP-Seq_YYC3_Human0.80241110
46SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79939230
47GATA6_21074721_ChIP-Seq_CACO-2_Human0.79923860
48ZNF263_19887448_ChIP-Seq_K562_Human0.79882495
49PIAS1_25552417_ChIP-Seq_VCAP_Human0.79110486
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78762876
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.76391787
52SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76270050
53SUZ12_27294783_Chip-Seq_NPCs_Mouse0.76165662
54TP53_18474530_ChIP-ChIP_U2OS_Human0.74029770
55SOX2_21211035_ChIP-Seq_LN229_Human0.73892881
56* RARA_24833708_ChIP-Seq_LIVER_Mouse0.72429457
57* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72361243
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71368642
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70852221
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70755156
61SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69184833
62CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68919464
63ER_23166858_ChIP-Seq_MCF-7_Human0.68571566
64CRX_20693478_ChIP-Seq_RETINA_Mouse0.67606891
65AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66227886
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65877284
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65681814
68OCT4_18555785_Chip-Seq_ESCs_Mouse0.64723763
69ESR2_21235772_ChIP-Seq_MCF-7_Human0.64366995
70RUNX1_27457419_Chip-Seq_LIVER_Mouse0.64288677
71TCF4_18268006_ChIP-ChIP_LS174T_Human0.63927512
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63737319
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.63435310
74RARB_24833708_ChIP-Seq_LIVER_Mouse0.63406994
75ETV1_20927104_ChIP-Seq_GIST48_Human0.63271421
76SMAD1_18555785_Chip-Seq_ESCs_Mouse0.63245258
77SOX2_20726797_ChIP-Seq_SW620_Human0.63055252
78ESRRB_18555785_Chip-Seq_ESCs_Mouse0.62582751
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62139763
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62139763
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61607562
82RAC3_21632823_ChIP-Seq_H3396_Human0.61162625
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.61101308
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.61096396
85RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60714672
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60659041
87ETV2_25802403_ChIP-Seq_MESCs_Mouse0.60646777
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.60240187
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.58113629
90KLF4_18555785_Chip-Seq_ESCs_Mouse0.58109667
91CEBPB_22108803_ChIP-Seq_LS180_Human0.57173701
92PU1_27457419_Chip-Seq_LIVER_Mouse0.56493502
93NFYB_21822215_ChIP-Seq_K562_Human0.55303930
94EGR1_19032775_ChIP-ChIP_M12_Human0.55229253
95PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.54281144
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54078882
97* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.53856726
98LXR_22292898_ChIP-Seq_THP-1_Human0.53660902
99RBPJ_21746931_ChIP-Seq_IB4_Human0.53467852
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53151738
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.52762818
102ZFX_18555785_Chip-Seq_ESCs_Mouse0.52760548
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.52667280
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.52594222
105AR_20517297_ChIP-Seq_VCAP_Human0.52463452
106CDX2_22108803_ChIP-Seq_LS180_Human0.52043838
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51215360
108MYC_19915707_ChIP-ChIP_AK7_Human0.50923764
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50482777
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49959384
111GATA1_19941826_ChIP-Seq_K562_Human0.47579938
112CBP_21632823_ChIP-Seq_H3396_Human0.47270434
113ESET_19884257_ChIP-Seq_ESCs_Mouse0.46831698
114P53_21459846_ChIP-Seq_SAOS-2_Human0.46788727
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46149242
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45152772
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.44756883
118ESR1_21235772_ChIP-Seq_MCF-7_Human0.43433881
119* STAT1_17558387_ChIP-Seq_HELA_Human0.42711093
120TAF2_19829295_ChIP-Seq_ESCs_Human0.42670480
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42422952
122GATA2_19941826_ChIP-Seq_K562_Human0.42202869
123FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41526529
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.41320019
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40673627
126FOXO3_23340844_ChIP-Seq_DLD1_Human0.40119692
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40026713
128GATA6_25053715_ChIP-Seq_YYC3_Human0.39292498
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.38959027
130TAF15_26573619_Chip-Seq_HEK293_Human0.38878863
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.37513918
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.37443262
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37297565
134ESR1_20079471_ChIP-ChIP_T-47D_Human0.36509404
135BCAT_22108803_ChIP-Seq_LS180_Human0.36092758
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.35045165
137LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34909136
138ERG_20517297_ChIP-Seq_VCAP_Human0.34509773
139FOXH1_21741376_ChIP-Seq_EPCs_Human0.33584702
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33570377
141SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.33233365
142GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.33156222
143NCOR_22424771_ChIP-Seq_293T_Human0.33100215

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.21514355
2MP0005360_urolithiasis7.54339876
3MP0005085_abnormal_gallbladder_physiolo6.42479195
4MP0005365_abnormal_bile_salt6.15916155
5MP0008875_abnormal_xenobiotic_pharmacok5.10832948
6MP0003806_abnormal_nucleotide_metabolis4.19081279
7MP0003252_abnormal_bile_duct3.86706381
8MP0010329_abnormal_lipoprotein_level3.65096031
9MP0009840_abnormal_foam_cell3.42153339
10MP0005083_abnormal_biliary_tract3.13344178
11MP0003195_calcinosis2.83710954
12MP0005332_abnormal_amino_acid2.76065361
13MP0001666_abnormal_nutrient_absorption2.57445327
14MP0003191_abnormal_cellular_cholesterol2.52555799
15MP0000609_abnormal_liver_physiology2.19179337
16MP0004019_abnormal_vitamin_homeostasis2.16138411
17MP0002118_abnormal_lipid_homeostasis2.10648934
18MP0002138_abnormal_hepatobiliary_system1.97720914
19MP0003868_abnormal_feces_composition1.91531916
20MP0005319_abnormal_enzyme/_coenzyme1.82397506
21MP0001764_abnormal_homeostasis1.68849515
22MP0009697_abnormal_copulation1.63064398
23MP0005584_abnormal_enzyme/coenzyme_acti1.57122892
24MP0003011_delayed_dark_adaptation1.49606392
25MP0005451_abnormal_body_composition1.43952580
26MP0003656_abnormal_erythrocyte_physiolo1.36736628
27MP0003186_abnormal_redox_activity1.27065004
28MP0009643_abnormal_urine_homeostasis1.23017396
29MP0000598_abnormal_liver_morphology1.20566027
30MP0003705_abnormal_hypodermis_morpholog1.15591376
31MP0000604_amyloidosis1.15079196
32MP0005647_abnormal_sex_gland1.10447636
33MP0004043_abnormal_pH_regulation1.09362851
34MP0002254_reproductive_system_inflammat1.07380523
35MP0009764_decreased_sensitivity_to1.06080709
36MP0009763_increased_sensitivity_to1.04129273
37MP0010368_abnormal_lymphatic_system1.00723891
38MP0005636_abnormal_mineral_homeostasis0.94143255
39MP0008469_abnormal_protein_level0.90021566
40* MP0009642_abnormal_blood_homeostasis0.87132714
41MP0005408_hypopigmentation0.85483965
42MP0005187_abnormal_penis_morphology0.83634438
43MP0006036_abnormal_mitochondrial_physio0.81382705
44MP0005376_homeostasis/metabolism_phenot0.81124966
45MP0009765_abnormal_xenobiotic_induced0.79494160
46MP0001915_intracranial_hemorrhage0.79157764
47MP0005670_abnormal_white_adipose0.78489825
48MP0002078_abnormal_glucose_homeostasis0.78067417
49MP0005084_abnormal_gallbladder_morpholo0.77919599
50MP0005220_abnormal_exocrine_pancreas0.73577453
51MP0002876_abnormal_thyroid_physiology0.72673458
52MP0003879_abnormal_hair_cell0.71918588
53MP0002971_abnormal_brown_adipose0.71550801
54MP0001661_extended_life_span0.69578553
55MP0009053_abnormal_anal_canal0.68108282
56MP0004130_abnormal_muscle_cell0.67927981
57MP0003690_abnormal_glial_cell0.67880107
58MP0005334_abnormal_fat_pad0.67780240
59MP0005535_abnormal_body_temperature0.65066161
60MP0000639_abnormal_adrenal_gland0.63609197
61MP0005266_abnormal_metabolism0.63418542
62MP0003329_amyloid_beta_deposits0.63396859
63MP0001756_abnormal_urination0.59822052
64MP0005464_abnormal_platelet_physiology0.59490550
65MP0005448_abnormal_energy_balance0.55535083
66MP0006035_abnormal_mitochondrial_morpho0.55152588
67MP0002282_abnormal_trachea_morphology0.52529901
68MP0005395_other_phenotype0.50567927
69MP0003718_maternal_effect0.47885082
70MP0002822_catalepsy0.46609169
71MP0003638_abnormal_response/metabolism_0.46041249
72MP0008873_increased_physiological_sensi0.45635087
73MP0002136_abnormal_kidney_physiology0.45386078
74MP0008874_decreased_physiological_sensi0.44353681
75MP0003436_decreased_susceptibility_to0.44006719
76MP0002928_abnormal_bile_duct0.43074300
77MP0003959_abnormal_lean_body0.42175195
78MP0003724_increased_susceptibility_to0.41945877
79MP0003075_altered_response_to0.41735354
80MP0005023_abnormal_wound_healing0.40954881
81MP0003953_abnormal_hormone_level0.40189553
82MP0002249_abnormal_larynx_morphology0.40089438
83MP0004782_abnormal_surfactant_physiolog0.39919957
84MP0002837_dystrophic_cardiac_calcinosis0.39381433
85MP0008872_abnormal_physiological_respon0.37896536
86MP0009672_abnormal_birth_weight0.37701040
87MP0005166_decreased_susceptibility_to0.37380194
88MP0005248_abnormal_Harderian_gland0.37256920
89MP0005666_abnormal_adipose_tissue0.37051547
90MP0004883_abnormal_blood_vessel0.37044192
91MP0000566_synostosis0.36539138
92MP0010386_abnormal_urinary_bladder0.36313193
93MP0000249_abnormal_blood_vessel0.34207046
94MP0001243_abnormal_dermal_layer0.33903556
95MP0000579_abnormal_nail_morphology0.33716955
96MP0009785_altered_susceptibility_to0.32961905
97MP0004381_abnormal_hair_follicle0.32651846
98MP0002796_impaired_skin_barrier0.32639511
99MP0009115_abnormal_fat_cell0.32374425
100MP0009384_cardiac_valve_regurgitation0.31085358
101MP0000230_abnormal_systemic_arterial0.30654741
102MP0002168_other_aberrant_phenotype0.30123506
103MP0002970_abnormal_white_adipose0.29804543
104MP0001853_heart_inflammation0.29370886
105MP0001845_abnormal_inflammatory_respons0.29146670
106MP0006082_CNS_inflammation0.29074355
107MP0005164_abnormal_response_to0.28972215
108MP0001881_abnormal_mammary_gland0.28195337
109MP0002132_abnormal_respiratory_system0.25168817
110MP0005058_abnormal_lysosome_morphology0.24467091
111MP0002090_abnormal_vision0.24176238
112MP0000467_abnormal_esophagus_morphology0.22943946
113MP0005197_abnormal_uvea_morphology0.21339618
114MP0002135_abnormal_kidney_morphology0.20511588
115MP0003632_abnormal_nervous_system0.19495483
116MP0002089_abnormal_postnatal_growth/wei0.19374894
117MP0000920_abnormal_myelination0.19296941
118MP0001944_abnormal_pancreas_morphology0.19167623
119MP0001851_eye_inflammation0.18378211
120MP0004272_abnormal_basement_membrane0.14950733

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.55028833
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39570978
3Intrahepatic cholestasis (HP:0001406)7.23157217
4Prolonged partial thromboplastin time (HP:0003645)6.70198412
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.67037757
6Hypobetalipoproteinemia (HP:0003563)6.48819803
7Xanthomatosis (HP:0000991)6.35442887
8Hyperlipoproteinemia (HP:0010980)5.61270233
9Complement deficiency (HP:0004431)5.35103394
10Joint hemorrhage (HP:0005261)4.94171465
11Hypolipoproteinemia (HP:0010981)4.93591008
12Abnormality of the common coagulation pathway (HP:0010990)4.63938220
13Hyperammonemia (HP:0001987)4.60691065
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.50394892
15Epidermoid cyst (HP:0200040)4.49989600
16Hypoalphalipoproteinemia (HP:0003233)4.37399307
17Hyperglycinemia (HP:0002154)4.34382000
18Abnormality of methionine metabolism (HP:0010901)4.34326286
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.24421630
20Ketosis (HP:0001946)4.21925533
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.14827778
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14594120
23Fat malabsorption (HP:0002630)4.06638777
24Abnormality of complement system (HP:0005339)3.90803956
25Abnormality of pyrimidine metabolism (HP:0004353)3.85281956
26Abnormality of serine family amino acid metabolism (HP:0010894)3.84960499
27Abnormality of glycine metabolism (HP:0010895)3.84960499
28Hyperglycinuria (HP:0003108)3.84506934
29Hypoglycemic coma (HP:0001325)3.84350481
30Abnormality of the intrinsic pathway (HP:0010989)3.83247929
31Hypercholesterolemia (HP:0003124)3.64961209
32Conjugated hyperbilirubinemia (HP:0002908)3.64705002
33Hyperbilirubinemia (HP:0002904)3.36911347
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30723905
35Abnormality of fatty-acid metabolism (HP:0004359)3.28212147
36Spontaneous abortion (HP:0005268)3.26285073
37Osteomalacia (HP:0002749)3.18104250
38Abnormality of serum amino acid levels (HP:0003112)3.05382789
39Hepatocellular carcinoma (HP:0001402)3.04650690
40Hypochromic microcytic anemia (HP:0004840)3.03350637
41Abnormality of nucleobase metabolism (HP:0010932)3.02952253
42Steatorrhea (HP:0002570)3.02240034
43Delayed CNS myelination (HP:0002188)3.01641514
44Ketoacidosis (HP:0001993)2.93181514
45Myocardial infarction (HP:0001658)2.90566605
46Hyperphosphaturia (HP:0003109)2.78698370
47Skin nodule (HP:0200036)2.78491275
48Metabolic acidosis (HP:0001942)2.74073210
49Acanthocytosis (HP:0001927)2.72743108
50Systemic lupus erythematosus (HP:0002725)2.72511282
51Reduced antithrombin III activity (HP:0001976)2.64405714
52Abnormality of purine metabolism (HP:0004352)2.61787401
53Lethargy (HP:0001254)2.59183976
54Glomerulonephritis (HP:0000099)2.56600333
55Glycosuria (HP:0003076)2.56157451
56Abnormality of urine glucose concentration (HP:0011016)2.56157451
57Vascular calcification (HP:0004934)2.54275891
58Dicarboxylic aciduria (HP:0003215)2.53249123
59Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53249123
60Abnormal gallbladder morphology (HP:0012437)2.51041882
61Hypoglycemic seizures (HP:0002173)2.46382821
62Amyloidosis (HP:0011034)2.46197893
63Cholelithiasis (HP:0001081)2.44998307
64Purpura (HP:0000979)2.44047758
65Spastic diplegia (HP:0001264)2.43664441
66Cerebral edema (HP:0002181)2.43515214
67Gout (HP:0001997)2.43040834
68Cholecystitis (HP:0001082)2.42707771
69Abnormal gallbladder physiology (HP:0012438)2.42707771
70Mitral stenosis (HP:0001718)2.38259119
71Gingival bleeding (HP:0000225)2.38251538
72Irritability (HP:0000737)2.34846472
73Recurrent gram-negative bacterial infections (HP:0005420)2.34016101
74Neonatal onset (HP:0003623)2.32595224
75Increased circulating renin level (HP:0000848)2.30342200
76Cardiovascular calcification (HP:0011915)2.25608134
77Esophageal varix (HP:0002040)2.25569351
78Abnormal urine phosphate concentration (HP:0012599)2.24810217
79Fair hair (HP:0002286)2.23168989
80Menorrhagia (HP:0000132)2.22429345
81Malnutrition (HP:0004395)2.20013903
82Thrombophlebitis (HP:0004418)2.19290098
83Elevated alkaline phosphatase (HP:0003155)2.17271464
84Abnormality of vitamin metabolism (HP:0100508)2.16335319
85Poikilocytosis (HP:0004447)2.15222037
86Pancreatitis (HP:0001733)2.13723728
87Enlarged kidneys (HP:0000105)2.13013120
88Proximal tubulopathy (HP:0000114)2.09213223
89Brushfield spots (HP:0001088)2.08732281
90Sensorimotor neuropathy (HP:0007141)2.08066319
91Late onset (HP:0003584)2.05594028
92Vomiting (HP:0002013)2.04754267
93Arthropathy (HP:0003040)2.04573703
94Abnormality of the gallbladder (HP:0005264)2.02552230
95Abnormality of the Achilles tendon (HP:0005109)2.01898937
96Hemorrhage of the eye (HP:0011885)1.99749657
97Generalized aminoaciduria (HP:0002909)1.99354436
98Hyperinsulinemic hypoglycemia (HP:0000825)1.99001381
99Abnormality of alkaline phosphatase activity (HP:0004379)1.98767412
100Opisthotonus (HP:0002179)1.97418417
101Abnormality of iron homeostasis (HP:0011031)1.94529545
102Metabolic alkalosis (HP:0200114)1.93133612
103Abnormality of transition element cation homeostasis (HP:0011030)1.91313848
104Rickets (HP:0002748)1.90212117
105Neonatal hypoglycemia (HP:0001998)1.87072765
106Bifid scrotum (HP:0000048)1.86938996
107Abnormal cartilage morphology (HP:0002763)1.86393130
108Hypophosphatemic rickets (HP:0004912)1.83467794
109Hypokalemic alkalosis (HP:0001949)1.82343185
110Alkalosis (HP:0001948)1.81134946
111Renal cortical cysts (HP:0000803)1.80659637
112Hydroxyprolinuria (HP:0003080)1.80488324
113Abnormality of proline metabolism (HP:0010907)1.80488324
114Nephritis (HP:0000123)1.80345881
115Elevated hepatic transaminases (HP:0002910)1.80188615
116Hypophosphatemia (HP:0002148)1.78578473
117Abnormal biliary tract physiology (HP:0012439)1.78549245
118Bile duct proliferation (HP:0001408)1.78549245
119Abnormal enzyme/coenzyme activity (HP:0012379)1.77855444
120Increased serum ferritin (HP:0003281)1.76105025
121Status epilepticus (HP:0002133)1.75357694
122Gangrene (HP:0100758)1.73069897
123Reticulocytosis (HP:0001923)1.72597068
124Pulmonary embolism (HP:0002204)1.72396759
125Potter facies (HP:0002009)1.69423913
126Facial shape deformation (HP:0011334)1.69423913
127Abnormal platelet function (HP:0011869)1.68935332
128Impaired platelet aggregation (HP:0003540)1.68935332
129Joint swelling (HP:0001386)1.67854315
130Hyperactive renin-angiotensin system (HP:0000841)1.67821604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK38.11368468
2BCKDK7.24602597
3FGFR44.65041202
4SIK14.47610590
5ERN14.40466295
6OXSR14.38858599
7INSRR3.02220856
8TAOK33.01619747
9ERBB42.92603541
10MAP2K42.32608097
11PKN22.29418935
12MST1R2.17414086
13MAPK111.96022431
14FLT31.95356934
15PIK3CA1.90149838
16TRIB31.82251782
17PIK3CG1.78694385
18TYK21.73764040
19LATS11.64595822
20DAPK21.58289228
21WNK41.54966922
22PTK61.50299474
23ABL21.49502864
24NEK91.45705289
25NTRK31.42970296
26KDR1.39128925
27FGFR21.34569978
28FRK1.32602399
29PRPF4B1.31296263
30JAK21.25173103
31MAP3K121.14722605
32MAP3K71.14159442
33PINK11.13470991
34PRKAA21.12811865
35GRK61.12744767
36MAP2K31.11103774
37MAP3K21.08649821
38ERBB21.06972038
39TBK11.05313949
40JAK11.02117291
41MAPK41.00050779
42MAP3K100.97934153
43MYLK0.95874316
44MUSK0.94650961
45MAP3K140.90655150
46MAP3K30.90507180
47PRKCZ0.90073769
48MET0.89918093
49EPHB10.89439625
50STK390.86644679
51PDK20.86598364
52MAP3K110.82765631
53STK38L0.82484297
54PRKACA0.82411338
55EPHA30.81785202
56MAPK120.81776990
57NLK0.81451100
58PRKG10.80215107
59TIE10.79678384
60CDK60.79523123
61PRKACG0.78552126
62MAPK150.74353785
63SGK10.73996479
64CAMK2G0.72087259
65CAMKK20.70921650
66CSK0.69451440
67DYRK1B0.68964752
68GSK3A0.68368747
69CAMK1D0.68162937
70SCYL20.67475699
71MAP2K60.66405771
72PRKAA10.65221160
73FER0.65157356
74RIPK10.64805003
75CSNK1D0.63774584
76TGFBR20.63629653
77TNK20.63093484
78PRKCB0.60907396
79SGK30.60326775
80PTK20.58568777
81BLK0.56842391
82FGFR30.56712516
83CSF1R0.56310885
84MAPK70.55546251
85ZAP700.54064663
86IKBKE0.53383958
87RPS6KA30.51807525
88IRAK30.50875708
89PDPK10.50488565
90PRKCQ0.49283902
91CSNK1G10.47266214
92TAOK20.46563567
93GRK10.45754838
94MAP2K10.45667927
95MAP3K50.44973042
96CSNK1A10.44503474
97EPHA40.43826340
98IGF1R0.42790342
99CDK40.42633177
100SGK20.42597643
101PRKCG0.42056139
102RET0.41779364
103PBK0.40277591
104SRC0.39242947
105CSNK1E0.39224817
106PKN10.39050909
107MAP3K60.38730650
108STK380.38636416
109MTOR0.35964449
110BRSK20.35811408
111MAP3K130.35259673
112EGFR0.34585443
113STK160.34395716
114ICK0.34332255
115KSR20.33697377
116CASK0.33579486
117EIF2AK10.31987814
118CAMKK10.31697052
119PDK10.31475536
120CAMK40.31196265
121SGK2230.30714517
122SGK4940.30714517
123CSNK2A10.29127016
124CSNK2A20.28946121
125MAP3K10.26912959
126CSNK1G20.26063693
127PRKCA0.25920778
128LATS20.25212947
129MAP2K20.24253899
130CSNK1G30.23380206
131PAK30.23158616
132BMX0.20829904
133ABL10.20369869
134IRAK10.19415703
135PRKACB0.18838332
136CAMK1G0.17971118
137MAPK30.17956327

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.47522352
2Nitrogen metabolism_Homo sapiens_hsa009103.73768274
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.46305427
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32817777
5Arginine biosynthesis_Homo sapiens_hsa002203.13230871
6* Complement and coagulation cascades_Homo sapiens_hsa046102.79968989
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67611442
8Tryptophan metabolism_Homo sapiens_hsa003802.65506274
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63866303
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56768804
11Fatty acid degradation_Homo sapiens_hsa000712.47552758
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35126019
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22316878
14Butanoate metabolism_Homo sapiens_hsa006502.12397805
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10767558
16Peroxisome_Homo sapiens_hsa041462.04653820
17Chemical carcinogenesis_Homo sapiens_hsa052041.93531061
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.90055258
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89960405
20Propanoate metabolism_Homo sapiens_hsa006401.89856876
21Histidine metabolism_Homo sapiens_hsa003401.88729046
22PPAR signaling pathway_Homo sapiens_hsa033201.86674753
23Staphylococcus aureus infection_Homo sapiens_hsa051501.82771602
24Fatty acid metabolism_Homo sapiens_hsa012121.80284189
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.76984770
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.74040272
27Caffeine metabolism_Homo sapiens_hsa002321.72013149
28beta-Alanine metabolism_Homo sapiens_hsa004101.69048079
29Retinol metabolism_Homo sapiens_hsa008301.67166937
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62572635
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60723943
32Selenocompound metabolism_Homo sapiens_hsa004501.60472730
33Phenylalanine metabolism_Homo sapiens_hsa003601.57755720
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53498889
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51525036
36Bile secretion_Homo sapiens_hsa049761.47023619
37Tyrosine metabolism_Homo sapiens_hsa003501.43558514
38Pyruvate metabolism_Homo sapiens_hsa006201.34734574
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.34679172
40Fatty acid elongation_Homo sapiens_hsa000621.33076877
41Sulfur metabolism_Homo sapiens_hsa009201.32428794
42Starch and sucrose metabolism_Homo sapiens_hsa005001.27157217
43Steroid biosynthesis_Homo sapiens_hsa001001.24284431
44Biosynthesis of amino acids_Homo sapiens_hsa012301.23271239
45Folate biosynthesis_Homo sapiens_hsa007901.19918157
46Fat digestion and absorption_Homo sapiens_hsa049751.19700106
47ABC transporters_Homo sapiens_hsa020101.18864522
48Carbon metabolism_Homo sapiens_hsa012001.13841035
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01815777
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01484857
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.99483291
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98461893
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.98365841
54Arginine and proline metabolism_Homo sapiens_hsa003300.96786531
55Sulfur relay system_Homo sapiens_hsa041220.94444816
56Vitamin digestion and absorption_Homo sapiens_hsa049770.89738608
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87796378
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83463612
59Lysine degradation_Homo sapiens_hsa003100.79465362
60One carbon pool by folate_Homo sapiens_hsa006700.77935754
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70650975
62Glycerolipid metabolism_Homo sapiens_hsa005610.66322390
63Glutathione metabolism_Homo sapiens_hsa004800.64397043
64Pentose phosphate pathway_Homo sapiens_hsa000300.61314207
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53586543
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47394817
67Metabolic pathways_Homo sapiens_hsa011000.45926721
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36555866
69Prion diseases_Homo sapiens_hsa050200.34167235
70Pertussis_Homo sapiens_hsa051330.27150165
71Galactose metabolism_Homo sapiens_hsa000520.26611237
72Fructose and mannose metabolism_Homo sapiens_hsa000510.25590244
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25428083
74Insulin resistance_Homo sapiens_hsa049310.22891718
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.22140238
76Linoleic acid metabolism_Homo sapiens_hsa005910.22104955
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21876391
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.16252906
79Glucagon signaling pathway_Homo sapiens_hsa049220.09825843
80AMPK signaling pathway_Homo sapiens_hsa041520.02210117
81Amoebiasis_Homo sapiens_hsa05146-0.2470357
82Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2468014
83Bladder cancer_Homo sapiens_hsa05219-0.2448579
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2408193
85Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2310522
86Ether lipid metabolism_Homo sapiens_hsa00565-0.2275904
87Circadian rhythm_Homo sapiens_hsa04710-0.2174516
88N-Glycan biosynthesis_Homo sapiens_hsa00510-0.2122483
89Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1995115
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1849577
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1797686
92Hepatitis C_Homo sapiens_hsa05160-0.1757267
93Type II diabetes mellitus_Homo sapiens_hsa04930-0.1742731
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1739663
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1673654
96Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1612781
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1548653
98Sphingolipid metabolism_Homo sapiens_hsa00600-0.1493835
99Regulation of autophagy_Homo sapiens_hsa04140-0.1435703
100African trypanosomiasis_Homo sapiens_hsa05143-0.1287774
101Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1145288
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1020178
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0994350
104Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0704933
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0582663
106Mineral absorption_Homo sapiens_hsa04978-0.0480748
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0454620
108Serotonergic synapse_Homo sapiens_hsa04726-0.0282374
109Other glycan degradation_Homo sapiens_hsa00511-0.0007550

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