KNOP1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hematopoietic stem cell differentiation (GO:0060218)7.30414458
2monoubiquitinated protein deubiquitination (GO:0035520)6.08290645
3cell wall macromolecule catabolic process (GO:0016998)5.98776197
4establishment of protein localization to Golgi (GO:0072600)5.42848355
5nuclear pore complex assembly (GO:0051292)5.35984157
6cell wall macromolecule metabolic process (GO:0044036)5.03103888
7endothelial tube morphogenesis (GO:0061154)5.00437989
8morphogenesis of an endothelium (GO:0003159)5.00437989
9microtubule severing (GO:0051013)4.94036626
10protein targeting to Golgi (GO:0000042)4.92831374
11seminiferous tubule development (GO:0072520)4.85263059
12retrograde transport, vesicle recycling within Golgi (GO:0000301)4.74198006
13Notch signaling involved in heart development (GO:0061314)4.69572031
14positive regulation of mitochondrial fission (GO:0090141)4.65422732
15cholesterol catabolic process (GO:0006707)4.63666155
16sterol catabolic process (GO:0016127)4.63666155
17mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.57561380
18neural tube formation (GO:0001841)4.43498110
19regulation of mitochondrial fission (GO:0090140)4.42716968
20aggressive behavior (GO:0002118)4.26458545
21nuclear pore organization (GO:0006999)4.12901334
22ventricular trabecula myocardium morphogenesis (GO:0003222)4.08040021
23mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.03866375
24alkaloid metabolic process (GO:0009820)3.95408892
25protein polyglutamylation (GO:0018095)3.94779278
26positive regulation of cardiac muscle cell differentiation (GO:2000727)3.93280531
27regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.92799028
28hepatocyte apoptotic process (GO:0097284)3.92671220
29snRNA transcription (GO:0009301)3.89168204
30regulation of RNA export from nucleus (GO:0046831)3.85148036
31protein localization to Golgi apparatus (GO:0034067)3.81069666
32pore complex assembly (GO:0046931)3.79827747
33regulation of centriole replication (GO:0046599)3.78117573
34regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.68272775
35DNA replication-dependent nucleosome organization (GO:0034723)3.67837801
36DNA replication-dependent nucleosome assembly (GO:0006335)3.67837801
37auditory receptor cell differentiation (GO:0042491)3.66936680
38DNA demethylation (GO:0080111)3.64028508
39regulation of nuclear cell cycle DNA replication (GO:0033262)3.59633873
40parental behavior (GO:0060746)3.50813777
41negative regulation of defense response to virus (GO:0050687)3.50502277
42centriole replication (GO:0007099)3.50277317
43heart field specification (GO:0003128)3.47389026
44secondary heart field specification (GO:0003139)3.47389026
45interleukin-6-mediated signaling pathway (GO:0070102)3.44888021
46meiotic chromosome segregation (GO:0045132)3.39317737
47mismatch repair (GO:0006298)3.36997870
48pericardium development (GO:0060039)3.34011025
49maternal behavior (GO:0042711)3.33897409
50pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32587910
51regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.31340080
52negative regulation of mast cell activation (GO:0033004)3.30899345
53DNA dealkylation (GO:0035510)3.25117492
54negative regulation of cell aging (GO:0090344)3.21873854
55TOR signaling (GO:0031929)3.18489859
56interkinetic nuclear migration (GO:0022027)3.13001228
57regulation of timing of cell differentiation (GO:0048505)3.10830028
58grooming behavior (GO:0007625)3.10454757
59glomerular visceral epithelial cell development (GO:0072015)3.06657372
60epithelial cell fate commitment (GO:0072148)3.05606114
61sperm motility (GO:0030317)3.00560855
62oxidative demethylation (GO:0070989)2.99133655
63striated muscle atrophy (GO:0014891)2.98280288
64heart trabecula morphogenesis (GO:0061384)2.97585845
65microtubule nucleation (GO:0007020)2.97053794
66acrosome assembly (GO:0001675)2.95789124
67pyrimidine nucleotide catabolic process (GO:0006244)2.95078693
68somatic hypermutation of immunoglobulin genes (GO:0016446)2.92605066
69somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92605066
70mitotic G2/M transition checkpoint (GO:0044818)2.92513069
71epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.92451381
72type B pancreatic cell development (GO:0003323)2.91226672
73sulfate transmembrane transport (GO:1902358)2.88499698
74inositol metabolic process (GO:0006020)2.88185612
75response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.86726911
76negative regulation of TOR signaling (GO:0032007)2.84707161
77positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.84532380
78mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.84532380
79skeletal muscle adaptation (GO:0043501)2.83852027
80intra-Golgi vesicle-mediated transport (GO:0006891)2.83215620
81sequestering of metal ion (GO:0051238)2.82846889
82regulation of nucleobase-containing compound transport (GO:0032239)2.81418431
83base-excision repair (GO:0006284)2.79450755
84fusion of sperm to egg plasma membrane (GO:0007342)2.77781952
85tyrosine phosphorylation of STAT protein (GO:0007260)2.77351113
86dentate gyrus development (GO:0021542)2.74743679
87regulation of development, heterochronic (GO:0040034)2.74106264
88generation of neurons (GO:0048699)2.72429730
89cilium or flagellum-dependent cell motility (GO:0001539)2.71121116
90inner ear receptor cell differentiation (GO:0060113)2.68751092
91mitotic G2 DNA damage checkpoint (GO:0007095)2.67584291
92attachment of spindle microtubules to kinetochore (GO:0008608)2.67248369
93sulfate transport (GO:0008272)2.65674625
94somite development (GO:0061053)2.64957255
95regulation of transmission of nerve impulse (GO:0051969)2.64325861
96DNA-dependent DNA replication (GO:0006261)2.64234142
97positive regulation of erythrocyte differentiation (GO:0045648)2.62989809
98sodium-independent organic anion transport (GO:0043252)2.60999923
99glomerular epithelial cell development (GO:0072310)2.59244197
100regulation of female receptivity (GO:0045924)2.58804762

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.90901979
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.84250458
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.57542668
4RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.39932111
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.38034509
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.77394811
7ESR1_20079471_ChIP-ChIP_T-47D_Human2.74221723
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.64019050
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.46908519
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.21809337
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.21016820
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.13323537
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.13323537
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.13323537
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse10.3732426
16VDR_22108803_ChIP-Seq_LS180_Human1.83219835
17FUS_26573619_Chip-Seq_HEK293_Human1.75860503
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73382248
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.72748232
20P300_19829295_ChIP-Seq_ESCs_Human1.72068235
21AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71997816
22ZNF274_21170338_ChIP-Seq_K562_Hela1.69674416
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54192751
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52208970
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47366031
26SMAD4_21799915_ChIP-Seq_A2780_Human1.45274526
27STAT3_23295773_ChIP-Seq_U87_Human1.44804698
28NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44329568
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43489579
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42935852
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40036554
32AR_21572438_ChIP-Seq_LNCaP_Human1.39038889
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38877681
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36445114
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.35155627
36NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32245366
37ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30519615
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.27043102
39CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27036162
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26705910
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24855841
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23406121
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23406121
44ER_23166858_ChIP-Seq_MCF-7_Human1.23373958
45GBX2_23144817_ChIP-Seq_PC3_Human1.23357910
46TAF15_26573619_Chip-Seq_HEK293_Human1.21497118
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19916495
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.18687837
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17720354
50BRD4_25478319_ChIP-Seq_HGPS_Human1.16935446
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16412995
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16223410
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14299467
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12449837
55EWS_26573619_Chip-Seq_HEK293_Human1.12403506
56RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10163969
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09992522
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09818034
59TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09021933
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07851266
61VDR_24787735_ChIP-Seq_THP-1_Human1.07442227
62SOX2_19829295_ChIP-Seq_ESCs_Human1.06776517
63NANOG_19829295_ChIP-Seq_ESCs_Human1.06776517
64SCL_19346495_ChIP-Seq_HPC-7_Human1.06657955
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.03787876
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03038786
67EZH2_22144423_ChIP-Seq_EOC_Human1.02902529
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.02437857
69ELK1_19687146_ChIP-ChIP_HELA_Human1.02141558
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01757519
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.01472503
72ARNT_22903824_ChIP-Seq_MCF-7_Human1.00493515
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00377121
74WT1_19549856_ChIP-ChIP_CCG9911_Human0.99634601
75CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98888702
76FLI1_27457419_Chip-Seq_LIVER_Mouse0.98750791
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98399509
78SMAD3_21741376_ChIP-Seq_EPCs_Human0.98261562
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98016347
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96514303
81CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93516721
82CRX_20693478_ChIP-Seq_RETINA_Mouse0.92493007
83CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91832337
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.90388713
85TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89237771
86TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89022239
87TCF4_23295773_ChIP-Seq_U87_Human0.88051724
88SMAD4_21741376_ChIP-Seq_EPCs_Human0.87733244
89NOTCH1_21737748_ChIP-Seq_TLL_Human0.87667130
90RXR_22108803_ChIP-Seq_LS180_Human0.87255395
91AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86548098
92CJUN_26792858_Chip-Seq_BT549_Human0.85243164
93ETV1_20927104_ChIP-Seq_GIST48_Human0.85220191
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.84476903
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.84316494
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84245867
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84221954
98AHR_22903824_ChIP-Seq_MCF-7_Human0.83696548
99TCF4_22108803_ChIP-Seq_LS180_Human0.83632116
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83378483

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH4.75809569
2MP0000569_abnormal_digit_pigmentation4.51521935
3MP0000013_abnormal_adipose_tissue4.17704930
4MP0002837_dystrophic_cardiac_calcinosis3.73381801
5MP0004084_abnormal_cardiac_muscle3.62007820
6MP0010307_abnormal_tumor_latency3.61180872
7MP0004233_abnormal_muscle_weight3.29446751
8MP0000003_abnormal_adipose_tissue3.06602200
9MP0005076_abnormal_cell_differentiation2.84292352
10MP0008058_abnormal_DNA_repair2.71723479
11MP0000371_diluted_coat_color2.68724603
12MP0008961_abnormal_basal_metabolism2.44205058
13MP0010094_abnormal_chromosome_stability2.36643925
14MP0001485_abnormal_pinna_reflex2.36005559
15MP0003787_abnormal_imprinting2.32869499
16MP0008775_abnormal_heart_ventricle2.21321372
17MP0009697_abnormal_copulation2.17792572
18MP0003943_abnormal_hepatobiliary_system1.95645556
19MP0003077_abnormal_cell_cycle1.91024930
20MP0004036_abnormal_muscle_relaxation1.85940739
21MP0000383_abnormal_hair_follicle1.81468233
22MP0005187_abnormal_penis_morphology1.76659149
23MP0004808_abnormal_hematopoietic_stem1.70955411
24MP0004885_abnormal_endolymph1.67693146
25MP0002396_abnormal_hematopoietic_system1.65949580
26MP0004742_abnormal_vestibular_system1.57461549
27MP0002168_other_aberrant_phenotype1.56526781
28MP0003111_abnormal_nucleus_morphology1.53245237
29MP0005174_abnormal_tail_pigmentation1.50662340
30MP0008877_abnormal_DNA_methylation1.41738649
31MP0005645_abnormal_hypothalamus_physiol1.39294964
32MP0003890_abnormal_embryonic-extraembry1.37593139
33MP0005375_adipose_tissue_phenotype1.37214176
34MP0005395_other_phenotype1.30583349
35MP0002009_preneoplasia1.24991589
36MP0001929_abnormal_gametogenesis1.24375097
37MP0004484_altered_response_of1.23123895
38MP0005410_abnormal_fertilization1.20878883
39MP0001502_abnormal_circadian_rhythm1.20370157
40MP0006138_congestive_heart_failure1.17702007
41MP0000516_abnormal_urinary_system1.16330847
42MP0005367_renal/urinary_system_phenotyp1.16330847
43MP0005551_abnormal_eye_electrophysiolog1.14741530
44MP0003786_premature_aging1.14001443
45MP0002938_white_spotting1.13248686
46MP0009250_abnormal_appendicular_skeleto1.08936934
47MP0003221_abnormal_cardiomyocyte_apopto1.07094892
48MP0003718_maternal_effect1.02969616
49MP0000627_abnormal_mammary_gland1.02392241
50MP0002088_abnormal_embryonic_growth/wei1.00469518
51MP0001545_abnormal_hematopoietic_system0.99153192
52MP0005397_hematopoietic_system_phenotyp0.99153192
53MP0010678_abnormal_skin_adnexa0.95520731
54MP0001672_abnormal_embryogenesis/_devel0.95331858
55MP0005380_embryogenesis_phenotype0.95331858
56MP0003763_abnormal_thymus_physiology0.95061435
57MP0009115_abnormal_fat_cell0.94081319
58MP0002075_abnormal_coat/hair_pigmentati0.94073258
59MP0004134_abnormal_chest_morphology0.93237518
60MP0002933_joint_inflammation0.88815557
61MP0003828_pulmonary_edema0.86092629
62MP0003984_embryonic_growth_retardation0.84483497
63MP0001346_abnormal_lacrimal_gland0.83001364
64MP0002210_abnormal_sex_determination0.82520939
65MP0000372_irregular_coat_pigmentation0.79334228
66MP0001486_abnormal_startle_reflex0.78287915
67MP0000538_abnormal_urinary_bladder0.77935373
68MP0002095_abnormal_skin_pigmentation0.77907659
69MP0004215_abnormal_myocardial_fiber0.77503299
70MP0001186_pigmentation_phenotype0.76286963
71MP0008057_abnormal_DNA_replication0.76222201
72MP0000653_abnormal_sex_gland0.75527596
73MP0008260_abnormal_autophagy0.75302451
74MP0003698_abnormal_male_reproductive0.73906487
75MP0001784_abnormal_fluid_regulation0.73054147
76MP0001984_abnormal_olfaction0.71134338
77MP0005310_abnormal_salivary_gland0.70420678
78MP0002019_abnormal_tumor_incidence0.69742426
79MP0004957_abnormal_blastocyst_morpholog0.69597722
80MP0002086_abnormal_extraembryonic_tissu0.69303374
81MP0003950_abnormal_plasma_membrane0.69051462
82MP0002970_abnormal_white_adipose0.67425730
83MP0005452_abnormal_adipose_tissue0.66875577
84MP0001145_abnormal_male_reproductive0.66278213
85MP0009053_abnormal_anal_canal0.61625946
86MP0003011_delayed_dark_adaptation0.61394049
87MP0000470_abnormal_stomach_morphology0.60729360
88MP0000350_abnormal_cell_proliferation0.60525786
89MP0006035_abnormal_mitochondrial_morpho0.60289185
90MP0002161_abnormal_fertility/fecundity0.59296171
91MP0004142_abnormal_muscle_tone0.59127616
92MP0003959_abnormal_lean_body0.58665706
93MP0000733_abnormal_muscle_development0.58548795
94MP0008770_decreased_survivor_rate0.57593334
95MP0002932_abnormal_joint_morphology0.57512486
96MP0006036_abnormal_mitochondrial_physio0.56940495
97MP0002166_altered_tumor_susceptibility0.55748347
98MP0001697_abnormal_embryo_size0.54926334
99MP0003693_abnormal_embryo_hatching0.54206704
100MP0002735_abnormal_chemical_nociception0.53509373

Predicted human phenotypes

RankGene SetZ-score
1Rectal fistula (HP:0100590)5.35575140
2Rectovaginal fistula (HP:0000143)5.35575140
3Intestinal fistula (HP:0100819)5.18437884
4Generalized hypopigmentation of hair (HP:0011358)5.07899557
5Abnormal hair whorl (HP:0010721)4.58102211
6Vaginal fistula (HP:0004320)4.54877404
7Chronic hepatic failure (HP:0100626)4.52592443
8Septate vagina (HP:0001153)4.38215850
9Skull defect (HP:0001362)4.37291962
10Aplasia cutis congenita (HP:0001057)4.06357765
11Fair hair (HP:0002286)3.87828066
12Urethral obstruction (HP:0000796)3.82124888
13Hyperlipoproteinemia (HP:0010980)3.76855695
14Glioma (HP:0009733)3.59514974
15Portal hypertension (HP:0001409)3.53322063
16Hypoproteinemia (HP:0003075)3.47071320
17Medulloblastoma (HP:0002885)3.36793241
18Hypoplastic nipples (HP:0002557)3.35482469
19Abnormality of the hepatic vasculature (HP:0006707)3.24120487
20Thrombocytosis (HP:0001894)3.22545646
21Acute lymphatic leukemia (HP:0006721)3.21739852
22Volvulus (HP:0002580)2.98689131
23Horizontal nystagmus (HP:0000666)2.95294888
24Hypochromic microcytic anemia (HP:0004840)2.93573038
25Split foot (HP:0001839)2.91848283
26Supernumerary bones of the axial skeleton (HP:0009144)2.86465866
27Neoplasm of striated muscle (HP:0009728)2.84138171
28Exocrine pancreatic insufficiency (HP:0001738)2.81214304
29Abnormality of the nasal septum (HP:0000419)2.81116657
30Abnormal number of incisors (HP:0011064)2.80093249
31Depressed nasal tip (HP:0000437)2.65329641
32Progressive cerebellar ataxia (HP:0002073)2.64446081
33Anteriorly placed anus (HP:0001545)2.60794220
34Bilateral microphthalmos (HP:0007633)2.54012800
35Abnormality of the nasolacrimal system (HP:0000614)2.52759331
36Median cleft lip (HP:0000161)2.52078566
37Wide nose (HP:0000445)2.50475984
38Midline defect of the nose (HP:0004122)2.47214034
392-3 toe syndactyly (HP:0004691)2.47057739
40Neoplasm of the oral cavity (HP:0100649)2.44377164
41Tubulointerstitial nephritis (HP:0001970)2.43923744
42Hypoplasia of the fovea (HP:0007750)2.38322973
43Aplasia/Hypoplasia of the fovea (HP:0008060)2.38322973
44Ependymoma (HP:0002888)2.36257762
45Large earlobe (HP:0009748)2.36194443
46Hypoalbuminemia (HP:0003073)2.34208228
47Abnormal albumin level (HP:0012116)2.34208228
48Supernumerary ribs (HP:0005815)2.28152570
49Optic nerve coloboma (HP:0000588)2.26881126
50Clitoromegaly (HP:0000057)2.26763573
51T lymphocytopenia (HP:0005403)2.26565115
52Rhabdomyosarcoma (HP:0002859)2.22759399
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.22040466
54Abnormality of the fovea (HP:0000493)2.19096376
55Intestinal atresia (HP:0011100)2.19076458
56Autoimmune hemolytic anemia (HP:0001890)2.18771712
57Abnormality of T cell number (HP:0011839)2.18612537
58Neoplasm of the heart (HP:0100544)2.17723993
59Gaze-evoked nystagmus (HP:0000640)2.14415021
60Spontaneous abortion (HP:0005268)2.13487958
61Low anterior hairline (HP:0000294)2.09525108
62Tinnitus (HP:0000360)2.09128465
63Abnormality of the incisor (HP:0000676)2.02640727
64Chorioretinal coloboma (HP:0000567)2.01048008
65Abnormality of the renal cortex (HP:0011035)2.00365603
66Anal stenosis (HP:0002025)1.99886292
67Prominent supraorbital ridges (HP:0000336)1.98281530
68Intellectual disability, moderate (HP:0002342)1.95951615
69Broad face (HP:0000283)1.95126394
70Underdeveloped nasal alae (HP:0000430)1.94421974
71Ectopic anus (HP:0004397)1.94135590
72Abnormality of B cell number (HP:0010975)1.93943920
73Abnormality of methionine metabolism (HP:0010901)1.92058027
74B lymphocytopenia (HP:0010976)1.91989353
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91846959
76Postural tremor (HP:0002174)1.90859872
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.87414614
78Anterior segment dysgenesis (HP:0007700)1.86460917
79Abnormality of the heme biosynthetic pathway (HP:0010472)1.85537400
80Abnormality of the astrocytes (HP:0100707)1.81742630
81Astrocytoma (HP:0009592)1.81742630
82Abnormality of the renal medulla (HP:0100957)1.79357275
83Pancreatic fibrosis (HP:0100732)1.78108059
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.77097275
85Renal hypoplasia (HP:0000089)1.76753071
86Widely spaced teeth (HP:0000687)1.76457482
87Abnormality of sulfur amino acid metabolism (HP:0004339)1.76176963
88Small epiphyses (HP:0010585)1.75983633
89Esophageal varix (HP:0002040)1.74875859
90Lip pit (HP:0100267)1.74647403
91Short tibia (HP:0005736)1.74064499
92Abnormal hair laboratory examination (HP:0003328)1.71946533
93Pancreatic cysts (HP:0001737)1.70673648
94Broad nasal tip (HP:0000455)1.70578892
95Hypoplasia of the capital femoral epiphysis (HP:0003090)1.70300202
96Abnormality of the parietal bone (HP:0002696)1.68817308
97Skin pits (HP:0100276)1.64807366
98Congenital hepatic fibrosis (HP:0002612)1.63092170
99Aplasia/Hypoplasia of the nipples (HP:0006709)1.62640288
100Hypoplastic labia majora (HP:0000059)1.61063682

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK16.13512526
2ZAK5.42460303
3FRK3.65748568
4STK43.33150596
5EPHA33.08798968
6PLK42.93003306
7CASK2.92935803
8PKN12.54852996
9PIK3CA2.40516682
10BCKDK2.34173188
11TAOK32.22069857
12MST42.14602076
13CDK122.06382663
14CCNB12.01579391
15SCYL21.88174992
16INSRR1.81774837
17MAP3K11.70987823
18VRK11.59977493
19KDR1.59153093
20BRD41.55882128
21TRIM281.51980815
22MAP3K101.47873071
23NEK61.45837446
24FLT31.38292505
25MAP4K21.37264762
26BCR1.32651106
27AKT31.30221851
28MAPK131.27800556
29PAK31.20842773
30PNCK1.15433876
31SIK31.11822870
32PIM11.06012249
33STK241.05972495
34BRSK21.05490914
35TSSK61.02219985
36FER0.93208385
37PIK3CG0.92974512
38MAP3K80.90666008
39PRKAA10.87338634
40AURKB0.85518926
41NUAK10.85166581
42CAMK1G0.79702045
43CAMKK20.77801697
44MELK0.74345471
45ROCK10.73928460
46RPS6KA50.70109153
47FGFR30.66161037
48MET0.65790836
49BLK0.64967450
50PKN20.64898484
51STK160.62815561
52WEE10.61052310
53STK30.59964746
54CDK70.59122600
55MAPK140.58649332
56IRAK10.58020315
57FGFR10.57301834
58BMPR1B0.55538321
59PRKCQ0.54319103
60CDK20.53917216
61ERBB20.53776686
62GSK3B0.53106924
63CDK60.52065860
64CAMK10.51419968
65JAK10.50221131
66TEC0.49885865
67IKBKE0.49637627
68CDK30.49046380
69MAP3K20.47177948
70NLK0.46483506
71CHEK20.45839560
72MAP3K30.45820316
73PDK10.44994468
74PRKAA20.43307749
75MKNK20.42929847
76ATR0.42209042
77PLK20.41398786
78SGK20.40594939
79OBSCN0.40122330
80AKT20.40092092
81CDK10.39934081
82EGFR0.37855240
83STK390.36646298
84SGK30.35845138
85CDK40.35252022
86CDK80.34524589
87IKBKB0.33105313
88ATM0.33058706
89MAPK80.32936045
90MAP3K70.32206154
91MAPK10.32035997
92CHUK0.30373148
93BTK0.30197083
94CAMK1D0.28551638
95DAPK20.27783744
96MTOR0.27738732
97MST1R0.27525620
98JAK20.27473839
99WNK10.25738708
100MAPK30.23965839

Predicted pathways (KEGG)

RankGene SetZ-score
1Base excision repair_Homo sapiens_hsa034104.32893831
2Systemic lupus erythematosus_Homo sapiens_hsa053223.89202934
3Alcoholism_Homo sapiens_hsa050342.96328562
4Lysine degradation_Homo sapiens_hsa003102.69760693
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60658403
6Fanconi anemia pathway_Homo sapiens_hsa034602.59482669
7Dorso-ventral axis formation_Homo sapiens_hsa043202.48048967
8Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.29327728
9Cell cycle_Homo sapiens_hsa041102.09899667
10Viral carcinogenesis_Homo sapiens_hsa052032.08393728
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92188731
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.74927865
13Homologous recombination_Homo sapiens_hsa034401.66315638
14Circadian rhythm_Homo sapiens_hsa047101.66284359
15RNA transport_Homo sapiens_hsa030131.65497289
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65310274
17Regulation of autophagy_Homo sapiens_hsa041401.62553504
18Transcriptional misregulation in cancer_Homo sapiens_hsa052021.61503198
19Mismatch repair_Homo sapiens_hsa034301.40493297
20Fatty acid biosynthesis_Homo sapiens_hsa000611.40244695
21Inositol phosphate metabolism_Homo sapiens_hsa005621.34922466
22Mineral absorption_Homo sapiens_hsa049781.27949795
23MicroRNAs in cancer_Homo sapiens_hsa052061.27377762
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.25440578
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24877292
26Herpes simplex infection_Homo sapiens_hsa051681.20203627
27TGF-beta signaling pathway_Homo sapiens_hsa043501.20120208
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16986884
29Non-small cell lung cancer_Homo sapiens_hsa052231.15570103
30p53 signaling pathway_Homo sapiens_hsa041151.15424666
31Non-homologous end-joining_Homo sapiens_hsa034501.13684376
32FoxO signaling pathway_Homo sapiens_hsa040681.12457409
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.12353180
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06147329
35Measles_Homo sapiens_hsa051621.04604651
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99634328
37Calcium signaling pathway_Homo sapiens_hsa040200.99247684
38African trypanosomiasis_Homo sapiens_hsa051430.98861492
39Small cell lung cancer_Homo sapiens_hsa052220.98634386
40mRNA surveillance pathway_Homo sapiens_hsa030150.97687777
41TNF signaling pathway_Homo sapiens_hsa046680.95705430
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95512294
43Phototransduction_Homo sapiens_hsa047440.91841953
44RNA degradation_Homo sapiens_hsa030180.90651470
45Fatty acid elongation_Homo sapiens_hsa000620.90359648
46Ovarian steroidogenesis_Homo sapiens_hsa049130.87374140
47Olfactory transduction_Homo sapiens_hsa047400.87364634
48Taste transduction_Homo sapiens_hsa047420.85693920
49Hedgehog signaling pathway_Homo sapiens_hsa043400.84619110
50Selenocompound metabolism_Homo sapiens_hsa004500.83439919
51DNA replication_Homo sapiens_hsa030300.80416484
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79290141
53HIF-1 signaling pathway_Homo sapiens_hsa040660.77887184
54Oocyte meiosis_Homo sapiens_hsa041140.75264408
55Basal transcription factors_Homo sapiens_hsa030220.73995995
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72379149
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69300893
58Caffeine metabolism_Homo sapiens_hsa002320.69003950
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66826614
60Hepatitis B_Homo sapiens_hsa051610.66253347
61Influenza A_Homo sapiens_hsa051640.65931372
62Steroid biosynthesis_Homo sapiens_hsa001000.65800856
63Nitrogen metabolism_Homo sapiens_hsa009100.64961092
64Pancreatic cancer_Homo sapiens_hsa052120.64892210
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.63181286
66Spliceosome_Homo sapiens_hsa030400.62274306
67RNA polymerase_Homo sapiens_hsa030200.61563980
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59381665
69Linoleic acid metabolism_Homo sapiens_hsa005910.54415170
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53588254
71Retinol metabolism_Homo sapiens_hsa008300.52693353
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52305164
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.51573514
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51391288
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50284208
76Primary immunodeficiency_Homo sapiens_hsa053400.49375526
77mTOR signaling pathway_Homo sapiens_hsa041500.49166237
78ABC transporters_Homo sapiens_hsa020100.48619052
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48485724
80Legionellosis_Homo sapiens_hsa051340.46785085
81Serotonergic synapse_Homo sapiens_hsa047260.45851819
82Insulin resistance_Homo sapiens_hsa049310.45575043
83Epstein-Barr virus infection_Homo sapiens_hsa051690.45227893
84Glioma_Homo sapiens_hsa052140.43511714
85Platelet activation_Homo sapiens_hsa046110.43434219
86Glycerolipid metabolism_Homo sapiens_hsa005610.42575923
87Pyrimidine metabolism_Homo sapiens_hsa002400.40018741
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39445201
89Allograft rejection_Homo sapiens_hsa053300.37182037
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.37171147
91Purine metabolism_Homo sapiens_hsa002300.36878425
92Prolactin signaling pathway_Homo sapiens_hsa049170.36628855
93One carbon pool by folate_Homo sapiens_hsa006700.36472836
94Nucleotide excision repair_Homo sapiens_hsa034200.34507256
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.33718600
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33116563
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33102238
98Acute myeloid leukemia_Homo sapiens_hsa052210.32292958
99Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29564899
100Prostate cancer_Homo sapiens_hsa052150.29053551

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