KNOP1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.76117726
2cullin deneddylation (GO:0010388)4.50146232
3intraciliary transport (GO:0042073)4.35254660
4DNA deamination (GO:0045006)4.05998908
5protein deneddylation (GO:0000338)4.04896374
6chromatin remodeling at centromere (GO:0031055)3.98270943
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.77197181
8CENP-A containing nucleosome assembly (GO:0034080)3.76763618
9RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.72154077
10exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.69515694
11snRNA processing (GO:0016180)3.68407181
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.63924200
13DNA replication-dependent nucleosome assembly (GO:0006335)3.59057611
14DNA replication-dependent nucleosome organization (GO:0034723)3.59057611
15water-soluble vitamin biosynthetic process (GO:0042364)3.56936595
16RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49793050
17tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49793050
18lactate metabolic process (GO:0006089)3.45523792
19protein-cofactor linkage (GO:0018065)3.41558138
20chaperone-mediated protein transport (GO:0072321)3.41422449
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.40525208
22termination of RNA polymerase III transcription (GO:0006386)3.40525208
23maturation of 5.8S rRNA (GO:0000460)3.38059103
24IMP biosynthetic process (GO:0006188)3.37045113
25mismatch repair (GO:0006298)3.36813311
26rRNA modification (GO:0000154)3.32326577
27spliceosomal snRNP assembly (GO:0000387)3.30692507
28protein localization to cilium (GO:0061512)3.28855441
29snRNA metabolic process (GO:0016073)3.27043320
30histone mRNA metabolic process (GO:0008334)3.24114051
31fatty acid elongation (GO:0030497)3.23872094
32peptidyl-arginine omega-N-methylation (GO:0035247)3.23594885
33regulation of helicase activity (GO:0051095)3.23184930
34regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.22138828
35regulation of mitotic spindle checkpoint (GO:1903504)3.22138828
36histone exchange (GO:0043486)3.20262257
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20256636
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.20256636
39NADH dehydrogenase complex assembly (GO:0010257)3.20256636
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.19554823
41DNA catabolic process, exonucleolytic (GO:0000738)3.14981644
42sequestering of actin monomers (GO:0042989)3.13423931
43rRNA methylation (GO:0031167)3.12827943
44purine nucleobase biosynthetic process (GO:0009113)3.11400849
45cholesterol biosynthetic process (GO:0006695)3.09293868
46mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04315203
47histone arginine methylation (GO:0034969)3.02543869
48DNA replication-independent nucleosome assembly (GO:0006336)3.00815503
49DNA replication-independent nucleosome organization (GO:0034724)3.00815503
50establishment of protein localization to mitochondrial membrane (GO:0090151)2.97879170
51regulation of DNA endoreduplication (GO:0032875)2.97113180
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96852617
53telomere maintenance via semi-conservative replication (GO:0032201)2.94701563
54termination of RNA polymerase II transcription (GO:0006369)2.90651824
55nucleobase biosynthetic process (GO:0046112)2.89177902
56DNA strand elongation involved in DNA replication (GO:0006271)2.88683466
57sterol biosynthetic process (GO:0016126)2.86614368
58peptidyl-histidine modification (GO:0018202)2.85597948
59mitochondrial respiratory chain complex assembly (GO:0033108)2.85585778
60pyrimidine nucleobase catabolic process (GO:0006208)2.85576289
61DNA damage response, detection of DNA damage (GO:0042769)2.84507478
62lysine metabolic process (GO:0006553)2.84372802
63lysine catabolic process (GO:0006554)2.84372802
64IMP metabolic process (GO:0046040)2.83999269
65mitochondrial RNA metabolic process (GO:0000959)2.83194797
66ATP synthesis coupled proton transport (GO:0015986)2.76075132
67energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76075132
68protein complex biogenesis (GO:0070271)2.75933445
69DNA strand elongation (GO:0022616)2.72022663
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.68098679
71peptidyl-arginine N-methylation (GO:0035246)2.65956031
72peptidyl-arginine methylation (GO:0018216)2.65956031
73attachment of spindle microtubules to kinetochore (GO:0008608)2.64044951
74regulation of nuclear cell cycle DNA replication (GO:0033262)2.62354553
75postreplication repair (GO:0006301)2.61288850
76somatic hypermutation of immunoglobulin genes (GO:0016446)2.61176220
77somatic diversification of immune receptors via somatic mutation (GO:0002566)2.61176220
78DNA-templated transcription, termination (GO:0006353)2.60967771
79tRNA metabolic process (GO:0006399)2.59990692
80telomere maintenance via recombination (GO:0000722)2.58395456
81behavioral response to nicotine (GO:0035095)2.58167370
82ubiquinone metabolic process (GO:0006743)2.57907864
83tRNA processing (GO:0008033)2.56798402
84S-adenosylmethionine metabolic process (GO:0046500)2.56104278
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55677849
86amino acid salvage (GO:0043102)2.55557651
87L-methionine salvage (GO:0071267)2.55557651
88L-methionine biosynthetic process (GO:0071265)2.55557651
89aspartate family amino acid catabolic process (GO:0009068)2.55547187
90iron-sulfur cluster assembly (GO:0016226)2.55257516
91metallo-sulfur cluster assembly (GO:0031163)2.55257516
92L-serine metabolic process (GO:0006563)2.54771441
93respiratory chain complex IV assembly (GO:0008535)2.52584047
94DNA replication checkpoint (GO:0000076)2.52398535
95serine family amino acid biosynthetic process (GO:0009070)2.51165330
96histone H2A acetylation (GO:0043968)2.48893057
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.48255335
98amino acid activation (GO:0043038)2.47957378
99tRNA aminoacylation (GO:0043039)2.47957378
100replication fork processing (GO:0031297)2.47607757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.22232988
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.21619484
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.50545167
4ZNF274_21170338_ChIP-Seq_K562_Hela3.38423908
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.27237091
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.09956236
7IGF1R_20145208_ChIP-Seq_DFB_Human2.84641625
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73993029
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60661888
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52857212
11E2F7_22180533_ChIP-Seq_HELA_Human2.42117355
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38037531
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.36371712
14ELK1_19687146_ChIP-ChIP_HELA_Human2.34113491
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28726018
16IRF1_19129219_ChIP-ChIP_H3396_Human2.28241732
17TAF15_26573619_Chip-Seq_HEK293_Human2.23352551
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17698414
19EWS_26573619_Chip-Seq_HEK293_Human2.15397128
20VDR_23849224_ChIP-Seq_CD4+_Human2.14300757
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.10406749
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.10237433
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07829952
24FUS_26573619_Chip-Seq_HEK293_Human2.07311848
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.02668583
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.02553375
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01723945
28FOXP3_21729870_ChIP-Seq_TREG_Human2.00416199
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97361325
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86588300
31PADI4_21655091_ChIP-ChIP_MCF-7_Human1.83963504
32PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79986823
33GBX2_23144817_ChIP-Seq_PC3_Human1.75611130
34MYC_18940864_ChIP-ChIP_HL60_Human1.74381322
35NOTCH1_21737748_ChIP-Seq_TLL_Human1.74344768
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69382322
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67390361
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63761904
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61513722
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57250583
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55664423
42GABP_19822575_ChIP-Seq_HepG2_Human1.54200975
43VDR_22108803_ChIP-Seq_LS180_Human1.52328093
44P300_19829295_ChIP-Seq_ESCs_Human1.49187841
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47636017
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45920937
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44172820
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43350614
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41847752
50DCP1A_22483619_ChIP-Seq_HELA_Human1.40092871
51FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.37408317
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37269427
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31848428
54XRN2_22483619_ChIP-Seq_HELA_Human1.27342575
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26769975
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26234251
57KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25926301
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24037998
59TP53_22573176_ChIP-Seq_HFKS_Human1.22636635
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22262233
61CBP_20019798_ChIP-Seq_JUKART_Human1.22262233
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21855401
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.20652922
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19982579
65TTF2_22483619_ChIP-Seq_HELA_Human1.19612900
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18694503
67E2F1_21310950_ChIP-Seq_MCF-7_Human1.12598950
68NANOG_19829295_ChIP-Seq_ESCs_Human1.11978642
69SOX2_19829295_ChIP-Seq_ESCs_Human1.11978642
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.11758464
71MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09306320
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09177554
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04053256
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03285597
75ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01522797
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00528844
77RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98223016
78KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98057839
79YY1_21170310_ChIP-Seq_MESCs_Mouse0.97815240
80ER_23166858_ChIP-Seq_MCF-7_Human0.96921617
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96741012
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93974669
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92654732
84RNF2_27304074_Chip-Seq_NSC_Mouse0.92312652
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90859781
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.90635904
87SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90517223
88AR_20517297_ChIP-Seq_VCAP_Human0.89848056
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89712854
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.88805177
91PIAS1_25552417_ChIP-Seq_VCAP_Human0.87087695
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87017018
93TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86726613
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.86473797
95MYC_19079543_ChIP-ChIP_MESCs_Mouse0.84530125
96AR_25329375_ChIP-Seq_VCAP_Human0.84134268
97ELK1_22589737_ChIP-Seq_MCF10A_Human0.82763019
98RUNX2_22187159_ChIP-Seq_PCA_Human0.81581798
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.81513228
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81413992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.24520213
2MP0008995_early_reproductive_senescence2.93265577
3MP0010094_abnormal_chromosome_stability2.73893270
4MP0008877_abnormal_DNA_methylation2.50845417
5MP0004133_heterotaxia2.49759736
6MP0008058_abnormal_DNA_repair2.44575751
7MP0003880_abnormal_central_pattern2.39438679
8MP0009697_abnormal_copulation2.35785650
9MP0001529_abnormal_vocalization2.29891766
10MP0003136_yellow_coat_color2.25520933
11MP0006072_abnormal_retinal_apoptosis2.21840890
12MP0003787_abnormal_imprinting2.14487428
13MP0006292_abnormal_olfactory_placode2.13208644
14MP0003786_premature_aging2.11662127
15MP0005171_absent_coat_pigmentation2.11486405
16MP0000372_irregular_coat_pigmentation2.06890838
17MP0003119_abnormal_digestive_system1.95511698
18MP0005253_abnormal_eye_physiology1.91364926
19MP0008789_abnormal_olfactory_epithelium1.85466933
20MP0005187_abnormal_penis_morphology1.83728556
21MP0005645_abnormal_hypothalamus_physiol1.82102451
22MP0004215_abnormal_myocardial_fiber1.81795637
23MP0008057_abnormal_DNA_replication1.74747636
24MP0006276_abnormal_autonomic_nervous1.72601361
25MP0008932_abnormal_embryonic_tissue1.66758975
26MP0003941_abnormal_skin_development1.64972160
27MP0001984_abnormal_olfaction1.61956096
28MP0001764_abnormal_homeostasis1.59229587
29MP0005646_abnormal_pituitary_gland1.57064855
30MP0005499_abnormal_olfactory_system1.56638975
31MP0005394_taste/olfaction_phenotype1.56638975
32MP0003806_abnormal_nucleotide_metabolis1.56351205
33MP0002653_abnormal_ependyma_morphology1.56020732
34MP0003693_abnormal_embryo_hatching1.55001263
35MP0006036_abnormal_mitochondrial_physio1.54846852
36MP0003122_maternal_imprinting1.54381256
37MP0008007_abnormal_cellular_replicative1.53544010
38MP0009046_muscle_twitch1.51400043
39MP0002751_abnormal_autonomic_nervous1.48997798
40MP0002638_abnormal_pupillary_reflex1.47610382
41MP0000749_muscle_degeneration1.44647499
42MP0005551_abnormal_eye_electrophysiolog1.43602099
43MP0003121_genomic_imprinting1.42892783
44MP0003111_abnormal_nucleus_morphology1.42766809
45MP0002837_dystrophic_cardiac_calcinosis1.38650661
46MP0001486_abnormal_startle_reflex1.38428817
47MP0010386_abnormal_urinary_bladder1.34184801
48MP0003011_delayed_dark_adaptation1.32533115
49MP0000631_abnormal_neuroendocrine_gland1.29231848
50MP0003077_abnormal_cell_cycle1.28172462
51MP0003878_abnormal_ear_physiology1.27878194
52MP0005377_hearing/vestibular/ear_phenot1.27878194
53MP0004957_abnormal_blastocyst_morpholog1.23037347
54MP0001177_atelectasis1.22525422
55MP0003283_abnormal_digestive_organ1.20754622
56MP0000647_abnormal_sebaceous_gland1.20522499
57MP0002254_reproductive_system_inflammat1.19767992
58MP0002272_abnormal_nervous_system1.18972134
59MP0003937_abnormal_limbs/digits/tail_de1.17861330
60MP0001986_abnormal_taste_sensitivity1.14958755
61MP0000026_abnormal_inner_ear1.12178433
62MP0001346_abnormal_lacrimal_gland1.06933040
63MP0006035_abnormal_mitochondrial_morpho1.05571880
64MP0008961_abnormal_basal_metabolism1.04900846
65MP0009745_abnormal_behavioral_response1.02491238
66MP0005084_abnormal_gallbladder_morpholo1.02342137
67MP0003567_abnormal_fetal_cardiomyocyte1.02229727
68MP0002752_abnormal_somatic_nervous1.02028073
69MP0003137_abnormal_impulse_conducting1.01714076
70MP0003718_maternal_effect0.95434145
71MP0002090_abnormal_vision0.90911876
72MP0002184_abnormal_innervation0.90689105
73MP0003938_abnormal_ear_development0.90485193
74MP0001293_anophthalmia0.89756295
75MP0002938_white_spotting0.88982943
76MP0001963_abnormal_hearing_physiology0.88823689
77MP0000778_abnormal_nervous_system0.86661510
78MP0005195_abnormal_posterior_eye0.86007116
79MP0005647_abnormal_sex_gland0.85881988
80MP0001286_abnormal_eye_development0.85307867
81MP0005167_abnormal_blood-brain_barrier0.85025784
82MP0002160_abnormal_reproductive_system0.83461155
83MP0005266_abnormal_metabolism0.82984995
84MP0004197_abnormal_fetal_growth/weight/0.82483429
85MP0001188_hyperpigmentation0.82038882
86MP0002736_abnormal_nociception_after0.81660408
87MP0002734_abnormal_mechanical_nocicepti0.80903410
88MP0001485_abnormal_pinna_reflex0.80805728
89MP0004270_analgesia0.80239095
90MP0005391_vision/eye_phenotype0.79808560
91MP0003315_abnormal_perineum_morphology0.78406946
92MP0002557_abnormal_social/conspecific_i0.76443835
93MP0004145_abnormal_muscle_electrophysio0.75193899
94MP0003635_abnormal_synaptic_transmissio0.73896453
95MP0008775_abnormal_heart_ventricle0.72758072
96MP0002822_catalepsy0.71818572
97MP0003698_abnormal_male_reproductive0.71604829
98MP0003221_abnormal_cardiomyocyte_apopto0.71021958
99MP0009672_abnormal_birth_weight0.70886993
100MP0005410_abnormal_fertilization0.69240152

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)3.54866623
2Thyroid-stimulating hormone excess (HP:0002925)3.36659682
3Progressive inability to walk (HP:0002505)3.28255999
4Acute necrotizing encephalopathy (HP:0006965)3.27109530
5Nephronophthisis (HP:0000090)3.24914103
6Neonatal respiratory distress (HP:0002643)3.18740660
7Supernumerary spleens (HP:0009799)3.10075008
8Hyperglycinemia (HP:0002154)3.03892882
9True hermaphroditism (HP:0010459)2.97932390
10Colon cancer (HP:0003003)2.96424981
113-Methylglutaconic aciduria (HP:0003535)2.91886345
12Acute encephalopathy (HP:0006846)2.91521463
13Abnormal mitochondria in muscle tissue (HP:0008316)2.83677947
14Pancreatic fibrosis (HP:0100732)2.79869539
15Inability to walk (HP:0002540)2.75647603
16Medial flaring of the eyebrow (HP:0010747)2.68439454
17Mitochondrial inheritance (HP:0001427)2.66579598
18Exercise-induced muscle cramps (HP:0003710)2.65260198
19Progressive macrocephaly (HP:0004481)2.62077800
20Congenital primary aphakia (HP:0007707)2.58678918
21Gait imbalance (HP:0002141)2.54628582
22Abnormality of serine family amino acid metabolism (HP:0010894)2.53636003
23Abnormality of glycine metabolism (HP:0010895)2.53636003
24Pancreatic cysts (HP:0001737)2.51120299
25Increased CSF lactate (HP:0002490)2.49641802
26Short 1st metacarpal (HP:0010034)2.48302285
27Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.48302285
28Methylmalonic acidemia (HP:0002912)2.47327787
29Aplasia/Hypoplasia of the tibia (HP:0005772)2.43429959
30Hepatocellular necrosis (HP:0001404)2.35936788
31Abnormality of the renal medulla (HP:0100957)2.35405248
32Nephrogenic diabetes insipidus (HP:0009806)2.33803278
33Pancreatic islet-cell hyperplasia (HP:0004510)2.33101701
34Short tibia (HP:0005736)2.29987495
35Abnormal lung lobation (HP:0002101)2.29245726
36Cerebellar dysplasia (HP:0007033)2.27720847
37Hyperglycinuria (HP:0003108)2.27479131
38Abnormality of methionine metabolism (HP:0010901)2.18326251
39Degeneration of anterior horn cells (HP:0002398)2.17729164
40Abnormality of the anterior horn cell (HP:0006802)2.17729164
41Aplasia/hypoplasia of the humerus (HP:0006507)2.16932488
42Hyperinsulinemic hypoglycemia (HP:0000825)2.16084556
43Abnormality of the 1st metacarpal (HP:0010009)2.15806494
44Methylmalonic aciduria (HP:0012120)2.14561813
45Cerebral edema (HP:0002181)2.13982398
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12842617
47Abolished electroretinogram (ERG) (HP:0000550)2.11899080
48Increased serum lactate (HP:0002151)2.10521929
49Abnormality of the metopic suture (HP:0005556)2.06220733
50Leukodystrophy (HP:0002415)2.04997274
51Lactic acidosis (HP:0003128)2.03154210
52Dyskinesia (HP:0100660)2.01451202
53Abnormality of serum amino acid levels (HP:0003112)1.99432710
54Hepatic necrosis (HP:0002605)1.94561459
55Aplasia/Hypoplasia of the spleen (HP:0010451)1.94202894
56Molar tooth sign on MRI (HP:0002419)1.93549759
57Abnormality of midbrain morphology (HP:0002418)1.93549759
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93102618
59Abnormal protein N-linked glycosylation (HP:0012347)1.93102618
60Abnormal protein glycosylation (HP:0012346)1.93102618
61Abnormal glycosylation (HP:0012345)1.93102618
62Meckel diverticulum (HP:0002245)1.92912862
63Short humerus (HP:0005792)1.91835803
64Genital tract atresia (HP:0001827)1.91257374
65Lipid accumulation in hepatocytes (HP:0006561)1.89957731
66Synostosis involving the elbow (HP:0003938)1.89927624
67Humeroradial synostosis (HP:0003041)1.89927624
68Hypoglycemic seizures (HP:0002173)1.88627661
69Abnormality of the ileum (HP:0001549)1.87380605
70Vaginal atresia (HP:0000148)1.87149913
71Chromsome breakage (HP:0040012)1.85195956
72Aplasia/Hypoplasia of the uvula (HP:0010293)1.84224625
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.83790212
74Postaxial hand polydactyly (HP:0001162)1.82908494
75Tubular atrophy (HP:0000092)1.82213365
76Respiratory failure (HP:0002878)1.80328120
77Adactyly (HP:0009776)1.77402699
78Prominent metopic ridge (HP:0005487)1.77113353
79Alacrima (HP:0000522)1.76291222
80Congenital hepatic fibrosis (HP:0002612)1.76074902
81Fibular aplasia (HP:0002990)1.75843915
82Broad foot (HP:0001769)1.75814927
83Asplenia (HP:0001746)1.75502804
84Horseshoe kidney (HP:0000085)1.75378492
85Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73571517
86Polydipsia (HP:0001959)1.73299770
87Abnormal drinking behavior (HP:0030082)1.73299770
88Decreased lacrimation (HP:0000633)1.73246078
89Sloping forehead (HP:0000340)1.72012731
90Congenital stationary night blindness (HP:0007642)1.71810271
91Type II lissencephaly (HP:0007260)1.70627769
92Abnormality of the renal cortex (HP:0011035)1.69878845
93Type I transferrin isoform profile (HP:0003642)1.69196595
94Postaxial foot polydactyly (HP:0001830)1.69009777
95Sclerocornea (HP:0000647)1.68556458
96Hypothermia (HP:0002045)1.68089171
97Abnormality of chromosome stability (HP:0003220)1.67168756
98Impulsivity (HP:0100710)1.67112745
99Congenital, generalized hypertrichosis (HP:0004540)1.66833969
100Optic disc pallor (HP:0000543)1.65660521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK33.33289823
2SRPK13.09482570
3ZAK3.04548200
4TRIM282.94635889
5MAP4K22.59368650
6BUB12.51977071
7TNIK2.43756651
8EPHA32.11638206
9CDC72.05196816
10BCR1.99996688
11EPHA41.97017231
12PLK31.95406074
13WNK41.91861208
14TSSK61.89815564
15BCKDK1.80113658
16PASK1.79119399
17VRK21.77744090
18MKNK11.76200135
19STK391.70435453
20OBSCN1.66665416
21PLK21.63951001
22PINK11.63154217
23PBK1.61918091
24TAOK31.61846279
25GRK11.57797802
26BMPR1B1.54845248
27NEK11.53651657
28CSNK1G11.53596051
29CSNK1G31.51964356
30DYRK31.51655350
31MAP2K71.47543759
32NME11.45847448
33MAP3K41.44208331
34ADRBK21.41496459
35VRK11.39210668
36CSNK1G21.33054342
37CSNK1A1L1.32397434
38ATR1.32147835
39DYRK21.32075620
40BRSK21.30814911
41NUAK11.30705756
42ERBB31.27009282
43PRKD31.25394150
44PLK11.24867096
45MAPK131.23673885
46MKNK21.21995924
47NLK1.15851830
48PLK41.07586287
49FRK1.06944627
50FGR0.99096706
51TTK0.98512331
52PHKG20.82503340
53PHKG10.82503340
54BRSK10.81459605
55TXK0.81004945
56RPS6KA40.79058588
57STK160.78448420
58AURKB0.73138434
59DAPK20.69307562
60EIF2AK30.67539634
61ATM0.65291983
62DYRK1A0.60742568
63INSRR0.60392393
64ALK0.57258183
65RPS6KA50.56304651
66STK38L0.56168578
67CDK30.54350643
68FER0.52827383
69PAK30.52815050
70CSNK2A10.52650688
71TIE10.52616042
72PRKCG0.51843018
73EIF2AK10.49239318
74ERBB40.46965484
75DAPK10.45832311
76PRKCE0.45798981
77CCNB10.44887954
78CAMKK20.44259373
79CSNK2A20.43724026
80PRKCQ0.43041636
81OXSR10.42620433
82CLK10.42418507
83CSNK1A10.41743684
84MINK10.41617407
85DYRK1B0.39523766
86CAMK2A0.38569444
87PDK20.37691219
88CDK190.37395261
89WEE10.35936663
90CHEK20.35150767
91PRKACA0.35037699
92PRKACB0.34640878
93CAMK2B0.34083944
94CSNK1E0.33882884
95MST40.32192866
96CSNK1D0.31681201
97ADRBK10.29604171
98CDK140.29474409
99PRKDC0.28854863
100MARK10.28591639

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.08959040
2RNA polymerase_Homo sapiens_hsa030202.85440568
3DNA replication_Homo sapiens_hsa030302.84286751
4Proteasome_Homo sapiens_hsa030502.79994648
5Mismatch repair_Homo sapiens_hsa034302.68697283
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42735576
7Protein export_Homo sapiens_hsa030602.35270347
8Propanoate metabolism_Homo sapiens_hsa006402.21596408
9RNA degradation_Homo sapiens_hsa030182.15848936
10Oxidative phosphorylation_Homo sapiens_hsa001902.14803492
11Homologous recombination_Homo sapiens_hsa034402.14616899
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08075836
13Steroid biosynthesis_Homo sapiens_hsa001002.06323697
14Spliceosome_Homo sapiens_hsa030402.05395649
15Non-homologous end-joining_Homo sapiens_hsa034502.03924445
16Fanconi anemia pathway_Homo sapiens_hsa034601.96203370
17Fatty acid elongation_Homo sapiens_hsa000621.96076903
18Butanoate metabolism_Homo sapiens_hsa006501.92355603
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88745152
20Parkinsons disease_Homo sapiens_hsa050121.86950636
21One carbon pool by folate_Homo sapiens_hsa006701.83541129
22Basal transcription factors_Homo sapiens_hsa030221.79495965
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77666441
24Pyrimidine metabolism_Homo sapiens_hsa002401.70699113
25Base excision repair_Homo sapiens_hsa034101.65305264
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.61943941
27Nucleotide excision repair_Homo sapiens_hsa034201.60381149
28Purine metabolism_Homo sapiens_hsa002301.52456930
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50409302
30RNA transport_Homo sapiens_hsa030131.45942442
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41935833
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36819906
33Vitamin B6 metabolism_Homo sapiens_hsa007501.34539218
34Huntingtons disease_Homo sapiens_hsa050161.31394223
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30503194
36Nicotine addiction_Homo sapiens_hsa050331.27330667
37Pyruvate metabolism_Homo sapiens_hsa006201.26344178
38Selenocompound metabolism_Homo sapiens_hsa004501.19169748
39Ribosome_Homo sapiens_hsa030101.18538874
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15282350
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14184340
42Phototransduction_Homo sapiens_hsa047441.13922716
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12496268
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10747277
45Cell cycle_Homo sapiens_hsa041101.06193432
46Regulation of autophagy_Homo sapiens_hsa041401.01815633
47beta-Alanine metabolism_Homo sapiens_hsa004100.99017563
48Fatty acid metabolism_Homo sapiens_hsa012120.98837838
49Tryptophan metabolism_Homo sapiens_hsa003800.95950758
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.93809793
51Alzheimers disease_Homo sapiens_hsa050100.89932610
52GABAergic synapse_Homo sapiens_hsa047270.85827575
53Biosynthesis of amino acids_Homo sapiens_hsa012300.85286132
54Peroxisome_Homo sapiens_hsa041460.85078705
55Carbon metabolism_Homo sapiens_hsa012000.84648976
56Taste transduction_Homo sapiens_hsa047420.80683584
57Cardiac muscle contraction_Homo sapiens_hsa042600.80566770
58Collecting duct acid secretion_Homo sapiens_hsa049660.78527890
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77231899
60Metabolic pathways_Homo sapiens_hsa011000.77003385
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75795585
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73143921
63Ether lipid metabolism_Homo sapiens_hsa005650.72196961
64Glutathione metabolism_Homo sapiens_hsa004800.70765460
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66854198
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66343960
67Arginine and proline metabolism_Homo sapiens_hsa003300.63454282
68Morphine addiction_Homo sapiens_hsa050320.62466566
69mRNA surveillance pathway_Homo sapiens_hsa030150.61552853
70Linoleic acid metabolism_Homo sapiens_hsa005910.61276867
71p53 signaling pathway_Homo sapiens_hsa041150.61124539
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61040435
73Primary immunodeficiency_Homo sapiens_hsa053400.59734976
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59646935
75Oocyte meiosis_Homo sapiens_hsa041140.59346579
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57509974
77Sulfur relay system_Homo sapiens_hsa041220.57499968
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56076803
79Olfactory transduction_Homo sapiens_hsa047400.55260732
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53376692
81Fatty acid degradation_Homo sapiens_hsa000710.53024098
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47094911
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.46357608
84Nitrogen metabolism_Homo sapiens_hsa009100.45303523
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43996578
86Circadian rhythm_Homo sapiens_hsa047100.43675027
87Circadian entrainment_Homo sapiens_hsa047130.42090152
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.39722514
89Folate biosynthesis_Homo sapiens_hsa007900.39695711
90Lysine degradation_Homo sapiens_hsa003100.39670963
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37885339
92Salivary secretion_Homo sapiens_hsa049700.37839191
93Arachidonic acid metabolism_Homo sapiens_hsa005900.36334069
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33629778
95Retinol metabolism_Homo sapiens_hsa008300.30678609
96Insulin secretion_Homo sapiens_hsa049110.27610363
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26925978
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26364133
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25786404
100Chemical carcinogenesis_Homo sapiens_hsa052040.25465497

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »