KNTC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.72096634
2nuclear pore organization (GO:0006999)5.66242208
3protein localization to kinetochore (GO:0034501)5.61195587
4DNA unwinding involved in DNA replication (GO:0006268)5.48591977
5mitotic chromosome condensation (GO:0007076)4.93369098
6protein localization to chromosome, centromeric region (GO:0071459)4.89047288
7sister chromatid segregation (GO:0000819)4.84166783
8mitotic sister chromatid segregation (GO:0000070)4.82190953
9mitotic sister chromatid cohesion (GO:0007064)4.68064036
10DNA replication-dependent nucleosome assembly (GO:0006335)4.66311174
11DNA replication-dependent nucleosome organization (GO:0034723)4.66311174
12DNA replication initiation (GO:0006270)4.51100363
13DNA strand elongation involved in DNA replication (GO:0006271)4.46329832
14mitotic nuclear envelope disassembly (GO:0007077)4.45372093
15kinetochore organization (GO:0051383)4.38673317
16pore complex assembly (GO:0046931)4.37040122
17regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.33481238
18replication fork processing (GO:0031297)4.31729145
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.27887667
20mitotic metaphase plate congression (GO:0007080)4.26233609
21DNA strand elongation (GO:0022616)4.23840031
22non-recombinational repair (GO:0000726)4.18889054
23double-strand break repair via nonhomologous end joining (GO:0006303)4.18889054
24nuclear envelope disassembly (GO:0051081)4.17789432
25membrane disassembly (GO:0030397)4.17789432
26DNA double-strand break processing (GO:0000729)4.16725293
27regulation of histone H3-K9 methylation (GO:0051570)4.09781580
28attachment of spindle microtubules to kinetochore (GO:0008608)4.09739690
29telomere maintenance via semi-conservative replication (GO:0032201)4.09101713
30mitotic recombination (GO:0006312)4.04972143
31DNA geometric change (GO:0032392)4.04856981
32DNA duplex unwinding (GO:0032508)4.03915369
33regulation of sister chromatid cohesion (GO:0007063)4.01320507
34DNA replication checkpoint (GO:0000076)3.99283454
35positive regulation of chromosome segregation (GO:0051984)3.96904319
36metaphase plate congression (GO:0051310)3.93859936
37chromatin remodeling at centromere (GO:0031055)3.91289807
38positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.90672139
39positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.90672139
40positive regulation of mitotic sister chromatid separation (GO:1901970)3.90672139
41telomere maintenance via recombination (GO:0000722)3.88762367
42DNA ligation (GO:0006266)3.88360188
43DNA synthesis involved in DNA repair (GO:0000731)3.87427139
44meiotic chromosome segregation (GO:0045132)3.85754098
45CENP-A containing nucleosome assembly (GO:0034080)3.79507163
46synapsis (GO:0007129)3.79350031
47sister chromatid cohesion (GO:0007062)3.78040159
48folic acid-containing compound biosynthetic process (GO:0009396)3.74917398
49regulation of spindle organization (GO:0090224)3.74681324
50negative regulation of DNA-dependent DNA replication (GO:2000104)3.71411134
51DNA replication-independent nucleosome organization (GO:0034724)3.70295293
52DNA replication-independent nucleosome assembly (GO:0006336)3.70295293
53dosage compensation (GO:0007549)3.65687567
54negative regulation of histone methylation (GO:0031061)3.65535705
55chromatin assembly or disassembly (GO:0006333)3.63257569
56heterochromatin organization (GO:0070828)3.63197393
57regulation of centriole replication (GO:0046599)3.62347654
58regulation of chromosome segregation (GO:0051983)3.61599606
59protein localization to chromosome (GO:0034502)3.59843019
60establishment of chromosome localization (GO:0051303)3.59140398
61pre-miRNA processing (GO:0031054)3.57849537
62IMP biosynthetic process (GO:0006188)3.57142841
63protein K6-linked ubiquitination (GO:0085020)3.56656432
64kinetochore assembly (GO:0051382)3.55547471
65chromatin assembly (GO:0031497)3.55354335
66mitotic G2/M transition checkpoint (GO:0044818)3.54342715
67translesion synthesis (GO:0019985)3.54307216
68DNA strand renaturation (GO:0000733)3.53839197
69regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53731885
70regulation of centrosome cycle (GO:0046605)3.49449501
71chromosome condensation (GO:0030261)3.48767358
72DNA conformation change (GO:0071103)3.45778754
73histone exchange (GO:0043486)3.45677611
74chromosome segregation (GO:0007059)3.45482650
75centriole replication (GO:0007099)3.44450367
76resolution of meiotic recombination intermediates (GO:0000712)3.44282413
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.44180053
78regulation of mitotic spindle organization (GO:0060236)3.44166928
79spindle checkpoint (GO:0031577)3.40519008
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40198693
81double-strand break repair via homologous recombination (GO:0000724)3.39479183
82recombinational repair (GO:0000725)3.37969192
83telomere maintenance via telomere lengthening (GO:0010833)3.34257547
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.33600544
85somatic hypermutation of immunoglobulin genes (GO:0016446)3.33600544
86negative regulation of chromosome segregation (GO:0051985)3.33552365
87regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.32690756
88spindle assembly checkpoint (GO:0071173)3.32304272
89DNA topological change (GO:0006265)3.32230089
90purine nucleobase biosynthetic process (GO:0009113)3.27742872
91postreplication repair (GO:0006301)3.27305349
92nucleobase biosynthetic process (GO:0046112)3.27166170
93nuclear envelope organization (GO:0006998)3.25870784
94regulation of sister chromatid segregation (GO:0033045)3.24416813
95regulation of mitotic sister chromatid separation (GO:0010965)3.24416813
96regulation of mitotic sister chromatid segregation (GO:0033047)3.24416813
97regulation of DNA endoreduplication (GO:0032875)3.24284489
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23680604
99negative regulation of sister chromatid segregation (GO:0033046)3.23680604
100negative regulation of mitotic sister chromatid separation (GO:2000816)3.23680604
101negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23680604
102mitotic spindle assembly checkpoint (GO:0007094)3.18333238
103mitotic spindle checkpoint (GO:0071174)3.17075952
104DNA packaging (GO:0006323)3.15527016
105regulation of translational fidelity (GO:0006450)3.14847821
106regulation of RNA export from nucleus (GO:0046831)3.14473992
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14450276
108microtubule depolymerization (GO:0007019)3.14051332
109IMP metabolic process (GO:0046040)3.11202987
110regulation of helicase activity (GO:0051095)3.08188907
111ATP-dependent chromatin remodeling (GO:0043044)3.07340077
112regulation of centrosome duplication (GO:0010824)3.05038638
113telomere maintenance (GO:0000723)3.00847058
114maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.00807198
115formation of translation preinitiation complex (GO:0001731)2.98795244
116telomere organization (GO:0032200)2.98282373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.31393745
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.61757661
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.74381856
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.42402024
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.01136796
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70950993
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61400690
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58957828
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52757841
10AR_21909140_ChIP-Seq_LNCAP_Human2.51644887
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50323458
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.48179109
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.36841987
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14992207
15* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06016232
16E2F7_22180533_ChIP-Seq_HELA_Human11.6584498
17SALL1_21062744_ChIP-ChIP_HESCs_Human1.99466961
18MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96422915
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.86514903
20MYC_22102868_ChIP-Seq_BL_Human1.84609501
21XRN2_22483619_ChIP-Seq_HELA_Human1.83348091
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78074480
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.75572027
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70402697
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65825215
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.64530191
27NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62802985
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61586515
29FUS_26573619_Chip-Seq_HEK293_Human1.54453956
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.52164590
31VDR_23849224_ChIP-Seq_CD4+_Human1.51749618
32EWS_26573619_Chip-Seq_HEK293_Human1.47708210
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.43023274
34TP63_19390658_ChIP-ChIP_HaCaT_Human1.42386049
35KDM5A_27292631_Chip-Seq_BREAST_Human1.42145554
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41851433
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41557777
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40330434
39SOX2_18555785_ChIP-Seq_MESCs_Mouse1.40052439
40E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39497081
41CIITA_25753668_ChIP-Seq_RAJI_Human1.39421340
42* TTF2_22483619_ChIP-Seq_HELA_Human1.37561090
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37415074
44* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37341896
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36405544
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35622713
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34293426
48* ELK1_19687146_ChIP-ChIP_HELA_Human1.32582902
49MYC_18940864_ChIP-ChIP_HL60_Human1.30435669
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28962748
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27772454
52DCP1A_22483619_ChIP-Seq_HELA_Human1.27130123
53IRF1_19129219_ChIP-ChIP_H3396_Human1.26540770
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25425214
55* GABP_17652178_ChIP-ChIP_JURKAT_Human1.22879423
56GABP_19822575_ChIP-Seq_HepG2_Human1.20690674
57* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19523521
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19235305
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18691899
60KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18691899
61KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18691899
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18108578
63ZNF274_21170338_ChIP-Seq_K562_Hela1.18084567
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.16670089
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16570030
66SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14510628
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13754708
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13266400
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13235968
70* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13104564
71TFEB_21752829_ChIP-Seq_HELA_Human1.12669712
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11098469
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10086543
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10036755
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08439413
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07256472
77* NANOG_21062744_ChIP-ChIP_HESCs_Human1.05924310
78* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05538868
79VDR_21846776_ChIP-Seq_THP-1_Human1.04844616
80ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02700955
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02071959
82* SOX2_16153702_ChIP-ChIP_HESCs_Human1.01813610
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01804249
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00446131
85KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00201983
86TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99239691
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99152376
88SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98661426
89* NANOG_16153702_ChIP-ChIP_HESCs_Human0.98170189
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97982979
91TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95189326
92NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94644968
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94192618
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93866918
95IGF1R_20145208_ChIP-Seq_DFB_Human0.91062112
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90919413
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.90628437
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90239702
99FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87395819
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.86950932
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85349642
102ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84049592
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.82939034
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80518789
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79372382
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76946753
107PKCTHETA_26484144_Chip-Seq_BREAST_Human0.76369216
108CHD1_26751641_Chip-Seq_LNCaP_Human0.76185220
109SOX2_18692474_ChIP-Seq_MESCs_Mouse0.76092407
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75001621
111NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.74773896
112TAF15_26573619_Chip-Seq_HEK293_Human0.74731424
113VDR_22108803_ChIP-Seq_LS180_Human0.72991638
114YY1_21170310_ChIP-Seq_MESCs_Mouse0.72577269
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.72416779
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71881932
117ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.71609690
118SRF_21415370_ChIP-Seq_HL-1_Mouse0.70921813
119GATA1_22025678_ChIP-Seq_K562_Human0.69810594
120* SOX17_20123909_ChIP-Seq_XEN_Mouse0.67798674
121SOX9_26525672_Chip-Seq_HEART_Mouse0.67368654
122* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.65344913
123* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.64821665
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.63410188
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.61735634
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.61119147
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.58385452
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.55296231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.86794678
2MP0003111_abnormal_nucleus_morphology4.45279016
3MP0003693_abnormal_embryo_hatching4.27750329
4MP0008057_abnormal_DNA_replication4.07621180
5MP0003077_abnormal_cell_cycle3.79141616
6MP0004957_abnormal_blastocyst_morpholog3.67702403
7MP0010352_gastrointestinal_tract_polyps2.96419123
8MP0010307_abnormal_tumor_latency2.86152923
9MP0009697_abnormal_copulation2.77906368
10MP0008058_abnormal_DNA_repair2.69356830
11MP0008877_abnormal_DNA_methylation2.42729498
12MP0001730_embryonic_growth_arrest2.42724059
13MP0008932_abnormal_embryonic_tissue2.36297132
14MP0000350_abnormal_cell_proliferation2.35324193
15MP0008007_abnormal_cellular_replicative2.34865798
16MP0003123_paternal_imprinting2.31274243
17MP0005076_abnormal_cell_differentiation2.23852181
18MP0002009_preneoplasia2.08335271
19MP0003705_abnormal_hypodermis_morpholog2.03689039
20MP0005380_embryogenesis_phenotype1.95417690
21MP0001672_abnormal_embryogenesis/_devel1.95417690
22MP0002396_abnormal_hematopoietic_system1.95346816
23MP0006292_abnormal_olfactory_placode1.88960618
24MP0003121_genomic_imprinting1.86694491
25MP0001697_abnormal_embryo_size1.85962777
26MP0004197_abnormal_fetal_growth/weight/1.85370755
27MP0002084_abnormal_developmental_patter1.83580169
28MP0002085_abnormal_embryonic_tissue1.78049053
29MP0003984_embryonic_growth_retardation1.75880305
30MP0002088_abnormal_embryonic_growth/wei1.73045619
31MP0002086_abnormal_extraembryonic_tissu1.70631771
32MP0002080_prenatal_lethality1.61293023
33MP0003890_abnormal_embryonic-extraembry1.59794812
34MP0004808_abnormal_hematopoietic_stem1.57400232
35MP0003786_premature_aging1.52908799
36MP0000490_abnormal_crypts_of1.46973332
37MP0003567_abnormal_fetal_cardiomyocyte1.40974330
38MP0000569_abnormal_digit_pigmentation1.36418225
39MP0000313_abnormal_cell_death1.35156442
40MP0001293_anophthalmia1.34615504
41MP0002019_abnormal_tumor_incidence1.30859380
42MP0009278_abnormal_bone_marrow1.29368557
43MP0010030_abnormal_orbit_morphology1.28336790
44MP0002210_abnormal_sex_determination1.25258607
45MP0000537_abnormal_urethra_morphology1.21669333
46MP0003566_abnormal_cell_adhesion1.18790439
47MP0003937_abnormal_limbs/digits/tail_de1.17222290
48MP0008995_early_reproductive_senescence1.15794184
49MP0002938_white_spotting1.14530200
50MP0006072_abnormal_retinal_apoptosis1.13248167
51MP0001145_abnormal_male_reproductive1.11015571
52MP0003943_abnormal_hepatobiliary_system1.10073993
53MP0001545_abnormal_hematopoietic_system1.09811510
54MP0005397_hematopoietic_system_phenotyp1.09811510
55MP0009703_decreased_birth_body1.09709282
56MP0009053_abnormal_anal_canal1.08678372
57MP0002877_abnormal_melanocyte_morpholog1.07243108
58MP0001929_abnormal_gametogenesis1.06418632
59MP0002653_abnormal_ependyma_morphology1.05489386
60MP0000703_abnormal_thymus_morphology1.04018443
61MP0009672_abnormal_birth_weight1.01826586
62MP0000383_abnormal_hair_follicle0.99738348
63MP0005023_abnormal_wound_healing0.99692525
64MP0003119_abnormal_digestive_system0.98373329
65MP0000733_abnormal_muscle_development0.97095101
66MP0000427_abnormal_hair_cycle0.94451508
67MP0001915_intracranial_hemorrhage0.92812433
68MP0000653_abnormal_sex_gland0.92707249
69MP0002092_abnormal_eye_morphology0.92364820
70MP0004147_increased_porphyrin_level0.91581078
71MP0001849_ear_inflammation0.91157904
72MP0003787_abnormal_imprinting0.90976619
73MP0002697_abnormal_eye_size0.90627755
74MP0001346_abnormal_lacrimal_gland0.90173323
75MP0003315_abnormal_perineum_morphology0.88689819
76MP0003136_yellow_coat_color0.87893665
77MP0002111_abnormal_tail_morphology0.84999781
78MP0004264_abnormal_extraembryonic_tissu0.84906460
79MP0000428_abnormal_craniofacial_morphol0.84728013
80MP0005621_abnormal_cell_physiology0.84687996
81MP0006054_spinal_hemorrhage0.84567757
82MP0002751_abnormal_autonomic_nervous0.84107136
83MP0000432_abnormal_head_morphology0.83633982
84MP0002233_abnormal_nose_morphology0.83168211
85MP0010234_abnormal_vibrissa_follicle0.81900396
86MP0005384_cellular_phenotype0.81318578
87MP0002398_abnormal_bone_marrow0.80099389
88MP0002925_abnormal_cardiovascular_devel0.79455349
89MP0003935_abnormal_craniofacial_develop0.79255626
90MP0003699_abnormal_female_reproductive0.78396786
91MP0003115_abnormal_respiratory_system0.78188042
92MP0003718_maternal_effect0.77841289
93MP0002722_abnormal_immune_system0.76457180
94MP0006035_abnormal_mitochondrial_morpho0.75426518
95MP0000566_synostosis0.74801950
96MP0002161_abnormal_fertility/fecundity0.74115595
97MP0001286_abnormal_eye_development0.73369158
98MP0003941_abnormal_skin_development0.71659801
99MP0001661_extended_life_span0.71499519
100MP0005391_vision/eye_phenotype0.71033027
101MP0002234_abnormal_pharynx_morphology0.69931856
102MP0000631_abnormal_neuroendocrine_gland0.69821969
103MP0002075_abnormal_coat/hair_pigmentati0.69732147
104MP0010678_abnormal_skin_adnexa0.68581484
105MP0000371_diluted_coat_color0.68426749
106MP0001119_abnormal_female_reproductive0.67588095
107MP0000689_abnormal_spleen_morphology0.67496187
108MP0003283_abnormal_digestive_organ0.67402511
109MP0003763_abnormal_thymus_physiology0.67252177
110MP0005623_abnormal_meninges_morphology0.67247596
111MP0005395_other_phenotype0.66604929
112MP0000647_abnormal_sebaceous_gland0.66460035
113MP0003861_abnormal_nervous_system0.65620509
114MP0005389_reproductive_system_phenotype0.63559020
115MP0000477_abnormal_intestine_morphology0.63188657
116MP0008770_decreased_survivor_rate0.62960928
117MP0003385_abnormal_body_wall0.62286924
118MP0004133_heterotaxia0.61043082
119MP0004233_abnormal_muscle_weight0.60949323
120MP0003755_abnormal_palate_morphology0.60859965
121MP0000372_irregular_coat_pigmentation0.60200131
122MP0009333_abnormal_splenocyte_physiolog0.59858399
123MP0005253_abnormal_eye_physiology0.59689330
124MP0003698_abnormal_male_reproductive0.59268452
125MP0003448_altered_tumor_morphology0.59129737
126MP0002006_tumorigenesis0.58843475
127MP0002095_abnormal_skin_pigmentation0.58715138
128MP0000266_abnormal_heart_morphology0.57706004
129MP0005075_abnormal_melanosome_morpholog0.57250832
130MP0005647_abnormal_sex_gland0.56816457
131MP0000858_altered_metastatic_potential0.55427479
132MP0000358_abnormal_cell_content/0.55168341
133MP0002160_abnormal_reproductive_system0.53516578
134MP0001919_abnormal_reproductive_system0.53335458

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.79384572
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.57527046
3Ependymoma (HP:0002888)3.82223481
4Abnormality of chromosome stability (HP:0003220)3.70849028
5Medulloblastoma (HP:0002885)3.60784269
6Volvulus (HP:0002580)3.38216361
7Selective tooth agenesis (HP:0001592)3.35367957
8Birth length less than 3rd percentile (HP:0003561)3.21233428
9Increased nuchal translucency (HP:0010880)3.10582547
10Meckel diverticulum (HP:0002245)3.09859250
11Ectopic kidney (HP:0000086)3.08228787
12Colon cancer (HP:0003003)3.06240607
13Aplasia/Hypoplasia of the uvula (HP:0010293)3.05715102
14Impulsivity (HP:0100710)3.01463239
15Rhabdomyosarcoma (HP:0002859)2.98705083
16Abnormality of the ileum (HP:0001549)2.96965011
17Astrocytoma (HP:0009592)2.96943754
18Abnormality of the astrocytes (HP:0100707)2.96943754
19Reticulocytopenia (HP:0001896)2.95595797
20Short 4th metacarpal (HP:0010044)2.93535926
21Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.93535926
22Abnormality of the preputium (HP:0100587)2.87358676
23Abnormality of the labia minora (HP:0012880)2.82129762
24Deviation of the thumb (HP:0009603)2.74119392
25Proximal placement of thumb (HP:0009623)2.73779909
26Agnosia (HP:0010524)2.72978829
27Small intestinal stenosis (HP:0012848)2.72972964
28Duodenal stenosis (HP:0100867)2.72972964
29Glioma (HP:0009733)2.62351773
30Absent radius (HP:0003974)2.61085746
31Myelodysplasia (HP:0002863)2.57963631
32Abnormality of the carotid arteries (HP:0005344)2.54696645
33Patellar aplasia (HP:0006443)2.54017935
34Neoplasm of the oral cavity (HP:0100649)2.53302752
35Abnormality of cochlea (HP:0000375)2.48980298
36Cafe-au-lait spot (HP:0000957)2.46659796
37Neoplasm of striated muscle (HP:0009728)2.45053619
38Absent forearm bone (HP:0003953)2.41776367
39Aplasia involving forearm bones (HP:0009822)2.41776367
40Basal cell carcinoma (HP:0002671)2.41522581
41High pitched voice (HP:0001620)2.40901977
42Breast hypoplasia (HP:0003187)2.40835963
43Aplasia/Hypoplasia of the patella (HP:0006498)2.37934800
44Sloping forehead (HP:0000340)2.36658278
45Absent thumb (HP:0009777)2.36306837
46Prominent nose (HP:0000448)2.33588284
47Abnormal number of incisors (HP:0011064)2.32696999
48Missing ribs (HP:0000921)2.30772686
49Duplicated collecting system (HP:0000081)2.30430793
50High anterior hairline (HP:0009890)2.30273660
51Facial hemangioma (HP:0000329)2.29524589
52Abnormality of the duodenum (HP:0002246)2.27730275
53Cortical dysplasia (HP:0002539)2.27616216
5411 pairs of ribs (HP:0000878)2.19795849
55Neoplasm of the adrenal cortex (HP:0100641)2.18798210
56Short thumb (HP:0009778)2.18346647
57Biliary tract neoplasm (HP:0100574)2.18269333
58Acute myeloid leukemia (HP:0004808)2.17521625
59Nephroblastoma (Wilms tumor) (HP:0002667)2.17482034
60Atresia of the external auditory canal (HP:0000413)2.10895170
61Embryonal neoplasm (HP:0002898)2.10726296
62Abnormality of the fingertips (HP:0001211)2.06016830
63Abnormality of the anterior horn cell (HP:0006802)2.04180688
64Degeneration of anterior horn cells (HP:0002398)2.04180688
65Heterotopia (HP:0002282)2.03732853
66Abnormality of the renal collecting system (HP:0004742)2.01688782
67Gastrointestinal carcinoma (HP:0002672)2.01519968
68Malignant gastrointestinal tract tumors (HP:0006749)2.01519968
69Embryonal renal neoplasm (HP:0011794)2.01289146
70Abnormality of the 4th metacarpal (HP:0010012)2.01027092
71Supernumerary spleens (HP:0009799)2.00950643
72Abnormal lung lobation (HP:0002101)1.98579756
73Tracheoesophageal fistula (HP:0002575)1.97943045
74Neoplasm of the pancreas (HP:0002894)1.97503823
75Sandal gap (HP:0001852)1.97501553
76Aplasia/hypoplasia of the humerus (HP:0006507)1.96863863
77Aplasia/Hypoplasia of the sternum (HP:0006714)1.94042683
78Squamous cell carcinoma (HP:0002860)1.93958924
79Short humerus (HP:0005792)1.92473686
80Clubbing of toes (HP:0100760)1.91552184
81Bone marrow hypocellularity (HP:0005528)1.89508021
82Acute lymphatic leukemia (HP:0006721)1.89349567
83Skull defect (HP:0001362)1.88442544
84Long eyelashes (HP:0000527)1.88263282
85Abnormality of abdominal situs (HP:0011620)1.88196261
86Abdominal situs inversus (HP:0003363)1.88196261
87B lymphocytopenia (HP:0010976)1.86311673
88Deep philtrum (HP:0002002)1.85879313
89Rib fusion (HP:0000902)1.85805735
90Hyperacusis (HP:0010780)1.85742577
91Amaurosis fugax (HP:0100576)1.85445643
92Aplasia/Hypoplasia of the earlobes (HP:0009906)1.85000129
93Abnormality of chromosome segregation (HP:0002916)1.83583384
94Astigmatism (HP:0000483)1.83408679
95Small hand (HP:0200055)1.82416806
96Renal duplication (HP:0000075)1.82209986
97Duplication of thumb phalanx (HP:0009942)1.81785135
98Obsessive-compulsive behavior (HP:0000722)1.79470748
99Ovarian neoplasm (HP:0100615)1.78286161
100Morphological abnormality of the inner ear (HP:0011390)1.77541760
101Abnormality of DNA repair (HP:0003254)1.74468691
102Combined immunodeficiency (HP:0005387)1.74415243
103Overlapping toe (HP:0001845)1.73620627
104Horseshoe kidney (HP:0000085)1.72125085
105Cutaneous melanoma (HP:0012056)1.71590608
106Ankle contracture (HP:0006466)1.70944069
107Neoplasm of the colon (HP:0100273)1.70924953
108Renovascular hypertension (HP:0100817)1.69928156
109Abnormality of the calcaneus (HP:0008364)1.69315866
110Truncal obesity (HP:0001956)1.68545403
111Carpal bone hypoplasia (HP:0001498)1.68390721
112Abnormality of B cell number (HP:0010975)1.66738520
113Triphalangeal thumb (HP:0001199)1.66515618
114Supernumerary ribs (HP:0005815)1.66433696
115Irregular epiphyses (HP:0010582)1.66102874
116Arteriovenous malformation (HP:0100026)1.64960076
117Choanal atresia (HP:0000453)1.64156547
118Facial asymmetry (HP:0000324)1.62336296
119Breast carcinoma (HP:0003002)1.61317691
120Hypoplasia of the pons (HP:0012110)1.58800388
121Bifid tongue (HP:0010297)1.58098492
122Blepharophimosis (HP:0000581)1.57513990
123Clitoromegaly (HP:0000057)1.57230541
124Abnormality of pyrimidine metabolism (HP:0004353)1.55496445
125Abnormality of the pons (HP:0007361)1.55441205
126Pancreatic islet-cell hyperplasia (HP:0004510)1.54205412
127Oligohydramnios (HP:0001562)1.53370858
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.46446775
129Tubulointerstitial nephritis (HP:0001970)1.46182691
130Poikiloderma (HP:0001029)1.44246414
131Partial agenesis of the corpus callosum (HP:0001338)1.43708770
132Oligodactyly (hands) (HP:0001180)1.43378807
133Hypoplasia of the thymus (HP:0000778)1.42019803
134Intestinal atresia (HP:0011100)1.41229470

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.45121786
2CDK123.69050836
3WEE13.68984124
4NEK23.63574687
5TTK2.85764977
6BUB12.65999050
7EEF2K2.51988716
8NEK12.45152054
9PBK2.18605584
10SRPK12.08335963
11PLK12.05014724
12ATR2.01148061
13BMPR1B1.93788020
14NUAK11.87969807
15AURKB1.87055449
16CHEK21.86718268
17PASK1.86319068
18CDK41.81756010
19TAF11.78496862
20BRSK21.78172667
21RPS6KB21.76214701
22SCYL21.74554358
23TLK11.73869221
24CDK71.67926890
25EIF2AK11.65394915
26PKN21.63198065
27BRD41.61832701
28CHEK11.56081826
29STK101.54308395
30MKNK11.53968410
31PLK31.52614630
32CDK61.52393351
33PLK41.51648946
34STK41.50225889
35MAP3K101.48876837
36MAP3K81.48874214
37ACVR1B1.39814729
38TSSK61.38753958
39ATM1.29642067
40VRK21.25906134
41STK31.23944507
42ZAK1.21428261
43LATS11.20441403
44EPHA21.19962598
45TRIM281.18534574
46RPS6KA41.13540356
47MKNK21.12326590
48VRK11.09484765
49CDK21.07141516
50AURKA1.04887482
51CAMK1G1.03607011
52ALK1.03548738
53DYRK31.03321632
54FRK1.02898014
55MELK1.01778963
56BRSK11.01490984
57TTN0.99140175
58PIM10.98102127
59MTOR0.95384683
60PAK40.93251277
61TESK20.92051545
62WNK30.90732867
63PNCK0.88640532
64SMG10.88624319
65FLT30.86981624
66CDK10.86309122
67TGFBR10.85175257
68INSRR0.77956238
69CDK90.71659226
70ERBB30.70693189
71STK390.66642915
72PLK20.66197208
73NME20.62649426
74CLK10.62568424
75ICK0.61885301
76LRRK20.60673697
77CSNK1D0.58957505
78PRKDC0.57992267
79TRIB30.56674559
80CAMK1D0.55451936
81CDK30.55437836
82BCR0.54983206
83CCNB10.54818139
84FGFR20.54088601
85TNIK0.53140843
86CSNK2A20.51805221
87RPS6KA50.50763808
88PAK20.49260854
89STK38L0.47175493
90MAPK140.47001902
91PAK10.46069770
92MAP3K40.46067473
93EIF2AK30.45653407
94NLK0.44983788
95FGFR10.44670399
96MAP4K10.44325326
97PDGFRA0.44290880
98AKT20.44206172
99BRAF0.43567065
100CSNK2A10.42853229
101WNK40.41700692
102MAPKAPK50.41674868
103CSNK1E0.40531550
104PTK60.39611374
105PDK20.39527844
106ERBB40.39380148
107PDK40.39162134
108PDK30.39162134
109TESK10.38628962
110AKT10.38408472
111LATS20.38078936
112PRKCI0.37558296
113MST40.37070188
114CSNK1G10.34666707
115AKT30.33495997
116BMX0.33448050
117MAPK10.33266892
118GSK3B0.31493337
119NME10.31398391
120MAP2K30.31284031
121MARK30.30232924
122NEK90.28434529
123MET0.28073482
124TRPM70.27780609
125TEC0.26807921
126RAF10.25297995
127YES10.24939610
128RPS6KB10.22352672
129CSF1R0.21204241
130EIF2AK20.21078197
131CDK80.20553830
132MAPK100.17828807

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.04833125
2Mismatch repair_Homo sapiens_hsa034304.40413599
3Cell cycle_Homo sapiens_hsa041103.38097024
4Homologous recombination_Homo sapiens_hsa034403.16039653
5RNA transport_Homo sapiens_hsa030133.12138877
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.01331561
7Base excision repair_Homo sapiens_hsa034102.96196611
8Spliceosome_Homo sapiens_hsa030402.88818311
9One carbon pool by folate_Homo sapiens_hsa006702.88713801
10Fanconi anemia pathway_Homo sapiens_hsa034602.83048046
11Nucleotide excision repair_Homo sapiens_hsa034202.73239317
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32236887
13Systemic lupus erythematosus_Homo sapiens_hsa053222.29807049
14Non-homologous end-joining_Homo sapiens_hsa034502.29692206
15mRNA surveillance pathway_Homo sapiens_hsa030152.12531156
16p53 signaling pathway_Homo sapiens_hsa041151.85235976
17RNA degradation_Homo sapiens_hsa030181.73535811
18Viral carcinogenesis_Homo sapiens_hsa052031.59517270
19Ribosome_Homo sapiens_hsa030101.58526092
20Pyrimidine metabolism_Homo sapiens_hsa002401.57979131
21RNA polymerase_Homo sapiens_hsa030201.55069497
22Basal transcription factors_Homo sapiens_hsa030221.51151767
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.40862397
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33839858
25MicroRNAs in cancer_Homo sapiens_hsa052061.33093735
26Oocyte meiosis_Homo sapiens_hsa041141.31604103
27HTLV-I infection_Homo sapiens_hsa051661.12732504
28Propanoate metabolism_Homo sapiens_hsa006401.12698384
29Small cell lung cancer_Homo sapiens_hsa052221.11981344
30Epstein-Barr virus infection_Homo sapiens_hsa051691.10624305
31Alcoholism_Homo sapiens_hsa050341.09397005
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08724161
33Proteasome_Homo sapiens_hsa030501.05264691
34Herpes simplex infection_Homo sapiens_hsa051681.04416403
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03512183
36Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96708160
37Antigen processing and presentation_Homo sapiens_hsa046120.96086768
38Chronic myeloid leukemia_Homo sapiens_hsa052200.92959801
39Selenocompound metabolism_Homo sapiens_hsa004500.87603581
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85928234
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85005032
42Lysine degradation_Homo sapiens_hsa003100.83972226
43Colorectal cancer_Homo sapiens_hsa052100.83423382
44Steroid biosynthesis_Homo sapiens_hsa001000.82892811
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82752399
46Adherens junction_Homo sapiens_hsa045200.80870546
47Pyruvate metabolism_Homo sapiens_hsa006200.80699990
48Basal cell carcinoma_Homo sapiens_hsa052170.79314785
49Hippo signaling pathway_Homo sapiens_hsa043900.79076246
50TGF-beta signaling pathway_Homo sapiens_hsa043500.77956828
51Thyroid cancer_Homo sapiens_hsa052160.73644455
52Purine metabolism_Homo sapiens_hsa002300.71531502
53mTOR signaling pathway_Homo sapiens_hsa041500.69001031
54Notch signaling pathway_Homo sapiens_hsa043300.67162631
55Hepatitis B_Homo sapiens_hsa051610.65639471
56Protein export_Homo sapiens_hsa030600.64917759
57Biosynthesis of amino acids_Homo sapiens_hsa012300.63270897
58Bladder cancer_Homo sapiens_hsa052190.62760718
59Prostate cancer_Homo sapiens_hsa052150.61847926
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.61110706
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60826360
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59827584
63Apoptosis_Homo sapiens_hsa042100.58829673
64Viral myocarditis_Homo sapiens_hsa054160.57978009
65Pancreatic cancer_Homo sapiens_hsa052120.57277237
66Non-small cell lung cancer_Homo sapiens_hsa052230.57128312
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56360398
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54822610
69Carbon metabolism_Homo sapiens_hsa012000.54451806
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54223610
71Pathways in cancer_Homo sapiens_hsa052000.52868834
72Proteoglycans in cancer_Homo sapiens_hsa052050.52459186
73Pentose phosphate pathway_Homo sapiens_hsa000300.51995376
74Legionellosis_Homo sapiens_hsa051340.51130952
75Hedgehog signaling pathway_Homo sapiens_hsa043400.48987179
76NF-kappa B signaling pathway_Homo sapiens_hsa040640.48281181
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44400771
78Measles_Homo sapiens_hsa051620.44244972
79Fatty acid metabolism_Homo sapiens_hsa012120.44143533
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43002153
81HIF-1 signaling pathway_Homo sapiens_hsa040660.42957670
82Nitrogen metabolism_Homo sapiens_hsa009100.42852751
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.42599546
84Endometrial cancer_Homo sapiens_hsa052130.40052150
85Shigellosis_Homo sapiens_hsa051310.40012723
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.39594490
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.39054071
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38448514
89FoxO signaling pathway_Homo sapiens_hsa040680.37478813
90Influenza A_Homo sapiens_hsa051640.37225140
91Melanoma_Homo sapiens_hsa052180.36919367
92Primary immunodeficiency_Homo sapiens_hsa053400.35670443
93Acute myeloid leukemia_Homo sapiens_hsa052210.35115440
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34730291
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34105090
96Wnt signaling pathway_Homo sapiens_hsa043100.34092549
97Butanoate metabolism_Homo sapiens_hsa006500.33913427
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33328710
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32938431
100Tight junction_Homo sapiens_hsa045300.31872790
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31653883
102Focal adhesion_Homo sapiens_hsa045100.30947689
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.30852361
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29818389
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29505001
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29344925
107Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28915535
108Fatty acid biosynthesis_Homo sapiens_hsa000610.28273718
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26803288
110B cell receptor signaling pathway_Homo sapiens_hsa046620.26450134
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26363467
112Hematopoietic cell lineage_Homo sapiens_hsa046400.26099834
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.24303106
114Olfactory transduction_Homo sapiens_hsa047400.23817053
115Fatty acid elongation_Homo sapiens_hsa000620.22607999
116Toxoplasmosis_Homo sapiens_hsa051450.22565546
117N-Glycan biosynthesis_Homo sapiens_hsa005100.22449592
118Glioma_Homo sapiens_hsa052140.22203330
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.19839107
120ECM-receptor interaction_Homo sapiens_hsa045120.19537771
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.19354779
122Vitamin B6 metabolism_Homo sapiens_hsa007500.18555405
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.18429994
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.18423242
125Metabolic pathways_Homo sapiens_hsa011000.18097674
126Phototransduction_Homo sapiens_hsa047440.14108668
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12273608
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.12178660
129Ether lipid metabolism_Homo sapiens_hsa005650.11733116
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11186904
131Folate biosynthesis_Homo sapiens_hsa007900.10068542
132Taste transduction_Homo sapiens_hsa047420.08718578
133Inositol phosphate metabolism_Homo sapiens_hsa005620.08516210
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08306981

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