KPNA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of B cell apoptotic process (GO:0002903)9.66626543
2negative regulation of B cell mediated immunity (GO:0002713)6.51805025
3negative regulation of immunoglobulin mediated immune response (GO:0002890)6.51805025
4positive regulation of interleukin-8 biosynthetic process (GO:0045416)6.49868159
5regulation of B cell apoptotic process (GO:0002902)6.39712443
6negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.67962798
7negative regulation of T-helper cell differentiation (GO:0045623)5.67962798
8regulation of mitotic spindle organization (GO:0060236)5.38201917
9negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.99123061
10regulation of germinal center formation (GO:0002634)4.98701906
11regulation of cholesterol homeostasis (GO:2000188)4.96808803
12regulation of memory T cell differentiation (GO:0043380)4.92307238
13regulation of T-helper 2 cell differentiation (GO:0045628)4.86281853
14mitotic sister chromatid cohesion (GO:0007064)4.81490761
15auditory behavior (GO:0031223)4.75750465
16positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.75611187
17germinal center formation (GO:0002467)4.72597331
18negative regulation of digestive system process (GO:0060457)4.70104438
19Golgi transport vesicle coating (GO:0048200)4.45675503
20COPI coating of Golgi vesicle (GO:0048205)4.45675503
21negative regulation of type 2 immune response (GO:0002829)4.45287188
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45075631
23regulation of spindle organization (GO:0090224)4.41221780
24regulation of short-term neuronal synaptic plasticity (GO:0048172)4.36468865
25positive regulation of lipoprotein lipase activity (GO:0051006)4.35914829
26positive regulation of triglyceride lipase activity (GO:0061365)4.35914829
27regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.32838698
28C4-dicarboxylate transport (GO:0015740)4.30508742
29neuronal action potential propagation (GO:0019227)4.14895017
30dicarboxylic acid biosynthetic process (GO:0043650)4.09617689
31fibroblast migration (GO:0010761)4.01633985
32negative regulation of Rho protein signal transduction (GO:0035024)3.95987766
33positive regulation of receptor biosynthetic process (GO:0010870)3.91739610
34synaptic vesicle maturation (GO:0016188)3.90192749
35regulation of interleukin-8 biosynthetic process (GO:0045414)3.89907659
36glutamate secretion (GO:0014047)3.89565953
37positive regulation of triglyceride biosynthetic process (GO:0010867)3.85197892
38regulation of synaptic vesicle exocytosis (GO:2000300)3.84901962
39COPII vesicle coating (GO:0048208)3.82195253
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.79785020
41T cell apoptotic process (GO:0070231)3.76460858
42regulation of coenzyme metabolic process (GO:0051196)3.73249276
43regulation of cofactor metabolic process (GO:0051193)3.73249276
44immunoglobulin mediated immune response (GO:0016064)3.72934031
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.71191554
46L-amino acid import (GO:0043092)3.70360373
47negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.69593682
48mechanosensory behavior (GO:0007638)3.67853202
49protein localization to synapse (GO:0035418)3.66655964
50regulation of relaxation of muscle (GO:1901077)3.62567846
51nucleoside diphosphate biosynthetic process (GO:0009133)3.59147749
52response to food (GO:0032094)3.58452514
53negative regulation of alpha-beta T cell differentiation (GO:0046639)3.56914298
54regulation of synaptic vesicle transport (GO:1902803)3.55828272
55pore complex assembly (GO:0046931)3.55814822
56vocalization behavior (GO:0071625)3.54779907
57locomotory exploration behavior (GO:0035641)3.49336767
58regulation of glutamate receptor signaling pathway (GO:1900449)3.47280500
59protein localization to microtubule (GO:0035372)3.45276672
60negative regulation of DNA recombination (GO:0045910)3.44725977
61cell adhesion mediated by integrin (GO:0033627)3.44518205
62synaptic vesicle exocytosis (GO:0016079)3.43824283
63actin-myosin filament sliding (GO:0033275)3.42099281
64muscle filament sliding (GO:0030049)3.42099281
65regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.38590248
66response to auditory stimulus (GO:0010996)3.37461347
67exploration behavior (GO:0035640)3.31816522
68ADP metabolic process (GO:0046031)3.31201073
69neurotransmitter-gated ion channel clustering (GO:0072578)3.30340308
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.26805344
71monoubiquitinated protein deubiquitination (GO:0035520)3.26512556
72regulation of translational termination (GO:0006449)3.25939089
73actin-mediated cell contraction (GO:0070252)3.25635807
74regulation of sulfur metabolic process (GO:0042762)3.21812204
75positive regulation of fatty acid biosynthetic process (GO:0045723)3.21467843
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20834056
77endoplasmic reticulum organization (GO:0007029)3.19171598
78positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.18799214
79neuromuscular process controlling balance (GO:0050885)3.18589752
80positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.16980365
81positive regulation of cholesterol efflux (GO:0010875)3.16890981
82negative regulation of lymphocyte apoptotic process (GO:0070229)3.14337627
83regulation of NFAT protein import into nucleus (GO:0051532)3.13540195
84peptidyl-threonine dephosphorylation (GO:0035970)3.13163370
85lymphocyte apoptotic process (GO:0070227)3.06669241
86regulation of cholesterol storage (GO:0010885)3.05977996
87regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.01827555
88regulation of G0 to G1 transition (GO:0070316)3.01398462
89lipid particle organization (GO:0034389)2.99375066
90vesicle coating (GO:0006901)2.98022299
91ER overload response (GO:0006983)2.97526425
92sarcomere organization (GO:0045214)2.96420640
93regulation of neuronal synaptic plasticity (GO:0048168)2.96394251
94regulation of synapse structural plasticity (GO:0051823)2.95132311
95actin filament-based movement (GO:0030048)2.94601679
96regulation of DNA endoreduplication (GO:0032875)2.94493364
97tricarboxylic acid cycle (GO:0006099)2.92274306
98neurotransmitter secretion (GO:0007269)2.91535827
99regulation of long-term neuronal synaptic plasticity (GO:0048169)2.89868168
100nuclear pore organization (GO:0006999)2.89414600
101regulation of triglyceride biosynthetic process (GO:0010866)2.87472160
102sarcoplasmic reticulum calcium ion transport (GO:0070296)2.87435283
103B cell mediated immunity (GO:0019724)2.86672926
104regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.86244156
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85990208
106cerebellar Purkinje cell differentiation (GO:0021702)2.84028966
107regulation of cell communication by electrical coupling (GO:0010649)2.83244876
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82397582
109lysine metabolic process (GO:0006553)2.78682394
110lysine catabolic process (GO:0006554)2.78682394
111plasma membrane repair (GO:0001778)2.73511464
112protein targeting to lysosome (GO:0006622)2.72394678
113establishment of protein localization to vacuole (GO:0072666)2.72394678
114protein targeting to vacuole (GO:0006623)2.72394678
115positive regulation of macroautophagy (GO:0016239)2.70797298
116apoptotic cell clearance (GO:0043277)2.68445691
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68238222
118regulation of excitatory postsynaptic membrane potential (GO:0060079)2.67636291
119retina vasculature morphogenesis in camera-type eye (GO:0061299)2.67188608
120activation of protein kinase A activity (GO:0034199)2.66200882
121SMAD protein complex assembly (GO:0007183)2.66121001
122dendritic spine morphogenesis (GO:0060997)2.65511947
123nuclear pore complex assembly (GO:0051292)2.65491799
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63233671
125positive regulation of sterol transport (GO:0032373)2.62656362
126positive regulation of cholesterol transport (GO:0032376)2.62656362
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.62010638
128positive regulation of membrane potential (GO:0045838)2.60982055
129erythrocyte development (GO:0048821)2.60857858
130positive regulation of synapse maturation (GO:0090129)2.60427669
131cell communication by electrical coupling (GO:0010644)2.60186736
132negative regulation of dendrite morphogenesis (GO:0050774)2.60048481
133regulation of oxidative stress-induced neuron death (GO:1903203)2.59398101
134regulation of acyl-CoA biosynthetic process (GO:0050812)2.58416101
135AMP metabolic process (GO:0046033)2.58009644
136regulation of dendritic spine morphogenesis (GO:0061001)2.57877674
137regulation of RNA export from nucleus (GO:0046831)2.57499554
138regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.57215411
139establishment of nucleus localization (GO:0040023)2.56745665
140amino acid import (GO:0043090)2.56681952
141retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54551126
142regulation of transforming growth factor beta2 production (GO:0032909)2.53863295
143regulation of centriole replication (GO:0046599)2.51089578
144double-strand break repair via nonhomologous end joining (GO:0006303)2.48833493
145non-recombinational repair (GO:0000726)2.48833493
146protein localization to microtubule cytoskeleton (GO:0072698)2.46021824
147nuclear envelope disassembly (GO:0051081)2.44699751
148membrane disassembly (GO:0030397)2.44699751
149UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43785916
150cardiac muscle cell development (GO:0055013)2.41913009
151protein localization to cytoskeleton (GO:0044380)2.41025801
152membrane budding (GO:0006900)2.40978265
153negative regulation of TOR signaling (GO:0032007)2.40593560
154sister chromatid segregation (GO:0000819)2.37765884
155lactate metabolic process (GO:0006089)2.36974021
156nuclear envelope organization (GO:0006998)2.36959282
157positive regulation of mitochondrial fission (GO:0090141)2.36625047
158regulation of Rac protein signal transduction (GO:0035020)2.36207180
159DNA double-strand break processing (GO:0000729)2.35100724
160mitotic metaphase plate congression (GO:0007080)2.34628980
161mitotic nuclear envelope disassembly (GO:0007077)2.34441685
162protein K11-linked deubiquitination (GO:0035871)2.33801956
163actomyosin structure organization (GO:0031032)2.32242010
164protein localization to endosome (GO:0036010)2.30260494
165skeletal muscle contraction (GO:0003009)2.29131727
166establishment of chromosome localization (GO:0051303)2.29029737
167positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.28987940
168positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.28987940
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.28987940
170regulation of nucleobase-containing compound transport (GO:0032239)2.27757538
171response to lipoprotein particle (GO:0055094)2.27580670
172regulation of skeletal muscle cell differentiation (GO:2001014)2.27426654
173hippo signaling (GO:0035329)2.27282805
174aspartate family amino acid catabolic process (GO:0009068)2.25494885
175regulation of sister chromatid cohesion (GO:0007063)2.25448828
176early endosome to late endosome transport (GO:0045022)2.25254588
177metaphase plate congression (GO:0051310)2.24838111
178cholesterol biosynthetic process (GO:0006695)2.24515856
179macroautophagy (GO:0016236)2.24192378
180cardiac cell development (GO:0055006)2.24000963
181response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.21428407
182N-terminal protein amino acid acetylation (GO:0006474)2.19646434
183mitotic chromosome condensation (GO:0007076)2.19229080
184Golgi organization (GO:0007030)2.18853509
185heparin biosynthetic process (GO:0030210)2.18841364
186heparin metabolic process (GO:0030202)2.18841364
187regulation of skeletal muscle contraction (GO:0014819)2.18062632
188mitotic sister chromatid segregation (GO:0000070)2.15518891
189regulation of actin filament-based movement (GO:1903115)2.14545253
190protein ADP-ribosylation (GO:0006471)2.13912608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09073972
2E2F7_22180533_ChIP-Seq_HELA_Human4.49417066
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.03289832
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.09285347
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.89658753
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.79867313
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.78941886
8GBX2_23144817_ChIP-Seq_PC3_Human2.65111861
9* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.40152284
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.37840309
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24537240
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.18309169
13REST_21632747_ChIP-Seq_MESCs_Mouse2.16230090
14IGF1R_20145208_ChIP-Seq_DFB_Human2.01212071
15SMAD4_21799915_ChIP-Seq_A2780_Human1.92450769
16ELK1_19687146_ChIP-ChIP_HELA_Human1.92327613
17REST_18959480_ChIP-ChIP_MESCs_Mouse1.91243681
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88280824
19ESR1_15608294_ChIP-ChIP_MCF-7_Human1.86811398
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82596211
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.82374121
22* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79291800
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78938641
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73731708
25GATA1_22025678_ChIP-Seq_K562_Human1.72100294
26STAT3_23295773_ChIP-Seq_U87_Human1.70257979
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.69724250
28YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67872251
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67059024
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64921710
31* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62083423
32SOX2_21211035_ChIP-Seq_LN229_Gbm1.60286699
33FOXM1_23109430_ChIP-Seq_U2OS_Human1.59531112
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.58770598
35NRF2_20460467_ChIP-Seq_MEFs_Mouse1.58770598
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57712048
37TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.57273200
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56926523
39* BRD4_25478319_ChIP-Seq_HGPS_Human1.56619323
40* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53415421
41* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53415421
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51879078
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51495500
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50564494
45SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50333589
46AR_21572438_ChIP-Seq_LNCaP_Human1.49724122
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49237056
48GATA4_21415370_ChIP-Seq_HL-1_Mouse1.48703527
49TFEB_21752829_ChIP-Seq_HELA_Human1.48377539
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.48279793
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44805462
52FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44529848
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42499711
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41706539
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41181509
56ZNF274_21170338_ChIP-Seq_K562_Hela1.39690788
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38610533
58ZNF263_19887448_ChIP-Seq_K562_Human1.38012168
59P300_19829295_ChIP-Seq_ESCs_Human1.37041019
60YAP1_20516196_ChIP-Seq_MESCs_Mouse1.35563203
61CLOCK_20551151_ChIP-Seq_293T_Human1.34901692
62RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34560129
63* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33570800
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.32685555
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.32171036
66EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31385256
67AHR_22903824_ChIP-Seq_MCF-7_Human1.31343732
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31251284
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30623672
70ER_23166858_ChIP-Seq_MCF-7_Human1.30345459
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29778973
72E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28304371
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28297405
74FUS_26573619_Chip-Seq_HEK293_Human1.26806982
75EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26737881
76AR_21909140_ChIP-Seq_LNCAP_Human1.26391917
77* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26353180
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24729077
79NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.24436408
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23219903
81TAF15_26573619_Chip-Seq_HEK293_Human1.23175853
82DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23153332
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22973908
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.22038917
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.21801389
86FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.21368650
87DCP1A_22483619_ChIP-Seq_HELA_Human1.21061262
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20844969
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.20314914
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.20094457
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19186616
92* CJUN_26792858_Chip-Seq_BT549_Human1.19055328
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18988764
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.18427672
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16008174
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.15810074
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14883026
98* TP53_18474530_ChIP-ChIP_U2OS_Human1.14726236
99* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14438392
100GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14284608
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14177511
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13468075
103FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.13322325
104* AR_25329375_ChIP-Seq_VCAP_Human1.12855164
105EWS_26573619_Chip-Seq_HEK293_Human1.11959011
106MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11849145
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11518595
108AR_19668381_ChIP-Seq_PC3_Human1.11460347
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11399330
110TCF4_18268006_ChIP-ChIP_LS174T_Human1.10689009
111SMAD3_21741376_ChIP-Seq_EPCs_Human1.10607738
112* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09457260
113EGR1_19374776_ChIP-ChIP_THP-1_Human1.08398754
114* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07872579
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07249116
116TCF4_23295773_ChIP-Seq_U87_Human1.07064846
117CHD1_26751641_Chip-Seq_LNCaP_Human1.05936486
118PKCTHETA_26484144_Chip-Seq_BREAST_Human1.05750227
119* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.04118740
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03433044
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.03105677
122DROSHA_22980978_ChIP-Seq_HELA_Human1.02951098
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02826187
124SOX17_20123909_ChIP-Seq_XEN_Mouse1.02767314
125RXR_22108803_ChIP-Seq_LS180_Human1.01913560
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01825457
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01698923
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01165030
129E2F1_18555785_Chip-Seq_ESCs_Mouse1.00450715
130ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00291517
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99795062
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99543004
133* TP53_16413492_ChIP-PET_HCT116_Human0.98962411
134BCAT_22108803_ChIP-Seq_LS180_Human0.98768800
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98618215
136SOX9_26525672_Chip-Seq_HEART_Mouse0.98197720
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97723645
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96986230
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96984075
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96508196
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.95716563
142EP300_21415370_ChIP-Seq_HL-1_Mouse0.94980881
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93975252
144HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93074345
145ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92802725
146PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92646954
147RUNX2_22187159_ChIP-Seq_PCA_Human0.92568575
148ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92503959
149STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92296618
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91133349
151NANOG_18555785_Chip-Seq_ESCs_Mouse0.90137117
152FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90056093
153MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89887556
154FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89486844
155* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88501368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.85770201
2MP0004859_abnormal_synaptic_plasticity4.75684244
3MP0003191_abnormal_cellular_cholesterol4.35984953
4MP0004270_analgesia3.94537694
5MP0004145_abnormal_muscle_electrophysio3.83371959
6MP0003329_amyloid_beta_deposits3.79320402
7MP0003880_abnormal_central_pattern3.53680892
8MP0000569_abnormal_digit_pigmentation3.49112068
9MP0008057_abnormal_DNA_replication3.05752949
10MP0003635_abnormal_synaptic_transmissio3.02759034
11MP0009697_abnormal_copulation2.86002479
12MP0002332_abnormal_exercise_endurance2.76866876
13MP0003656_abnormal_erythrocyte_physiolo2.53210961
14MP0003646_muscle_fatigue2.41096501
15MP0010352_gastrointestinal_tract_polyps2.36634954
16MP0009745_abnormal_behavioral_response2.34395311
17MP0003950_abnormal_plasma_membrane2.33408798
18MP0005248_abnormal_Harderian_gland2.31405316
19MP0002063_abnormal_learning/memory/cond2.24852937
20MP0005365_abnormal_bile_salt2.20871011
21MP0006054_spinal_hemorrhage2.15377922
22MP0005623_abnormal_meninges_morphology2.11837592
23MP0000751_myopathy2.10399714
24MP0000604_amyloidosis2.09280420
25MP0002064_seizures1.98129723
26MP0002877_abnormal_melanocyte_morpholog1.89806933
27MP0001968_abnormal_touch/_nociception1.87965093
28MP0000747_muscle_weakness1.84607538
29MP0002734_abnormal_mechanical_nocicepti1.83415249
30MP0000749_muscle_degeneration1.82488305
31MP0004215_abnormal_myocardial_fiber1.80026971
32MP0002822_catalepsy1.79621340
33MP0003123_paternal_imprinting1.72943320
34MP0002837_dystrophic_cardiac_calcinosis1.69975871
35MP0005423_abnormal_somatic_nervous1.62030819
36MP0004084_abnormal_cardiac_muscle1.56125116
37MP0003941_abnormal_skin_development1.50243817
38MP0009046_muscle_twitch1.47740831
39MP0010234_abnormal_vibrissa_follicle1.46730794
40MP0004036_abnormal_muscle_relaxation1.45675235
41MP0002572_abnormal_emotion/affect_behav1.45433469
42MP0003787_abnormal_imprinting1.44369018
43MP0003566_abnormal_cell_adhesion1.43714412
44MP0001853_heart_inflammation1.41063018
45MP0002106_abnormal_muscle_physiology1.38400009
46MP0005451_abnormal_body_composition1.38360087
47MP0004087_abnormal_muscle_fiber1.36765807
48MP0003868_abnormal_feces_composition1.36690083
49MP0008007_abnormal_cellular_replicative1.36037164
50MP0006138_congestive_heart_failure1.35808746
51MP0008569_lethality_at_weaning1.34643916
52MP0001440_abnormal_grooming_behavior1.33995556
53MP0001529_abnormal_vocalization1.32928533
54MP0009780_abnormal_chondrocyte_physiolo1.32855269
55MP0001177_atelectasis1.32582900
56MP0004811_abnormal_neuron_physiology1.32520000
57MP0004924_abnormal_behavior1.31032363
58MP0005386_behavior/neurological_phenoty1.31032363
59MP0002272_abnormal_nervous_system1.30471488
60MP0002067_abnormal_sensory_capabilities1.28826966
61MP0002735_abnormal_chemical_nociception1.26350413
62MP0002736_abnormal_nociception_after1.25841637
63MP0000013_abnormal_adipose_tissue1.24550354
64MP0002184_abnormal_innervation1.23417141
65MP0004484_altered_response_of1.22109469
66MP0002909_abnormal_adrenal_gland1.20479292
67MP0003632_abnormal_nervous_system1.20419036
68MP0005620_abnormal_muscle_contractility1.19474591
69MP0001501_abnormal_sleep_pattern1.19046448
70MP0001486_abnormal_startle_reflex1.18714672
71MP0004197_abnormal_fetal_growth/weight/1.18521554
72MP0000733_abnormal_muscle_development1.18058847
73MP0004233_abnormal_muscle_weight1.17283525
74MP0008877_abnormal_DNA_methylation1.17249547
75MP0002009_preneoplasia1.16647982
76MP0003077_abnormal_cell_cycle1.13932564
77MP0003828_pulmonary_edema1.13789391
78MP0003631_nervous_system_phenotype1.13488359
79MP0005266_abnormal_metabolism1.13469643
80MP0003984_embryonic_growth_retardation1.13128843
81MP0001915_intracranial_hemorrhage1.12093681
82MP0004130_abnormal_muscle_cell1.12033594
83MP0003221_abnormal_cardiomyocyte_apopto1.10860802
84MP0001346_abnormal_lacrimal_gland1.10680269
85MP0010678_abnormal_skin_adnexa1.09655689
86MP0002088_abnormal_embryonic_growth/wei1.08973063
87MP0002269_muscular_atrophy1.08668029
88MP0001697_abnormal_embryo_size1.07893416
89MP0004272_abnormal_basement_membrane1.07105100
90MP0005647_abnormal_sex_gland1.06797750
91MP0005369_muscle_phenotype1.06225625
92MP0001672_abnormal_embryogenesis/_devel1.05235781
93MP0005380_embryogenesis_phenotype1.05235781
94MP0008058_abnormal_DNA_repair1.05228763
95MP0003091_abnormal_cell_migration1.01633257
96MP0000759_abnormal_skeletal_muscle1.01272746
97MP0003633_abnormal_nervous_system0.99892001
98MP0000427_abnormal_hair_cycle0.98388162
99MP0003705_abnormal_hypodermis_morpholog0.98368801
100MP0001661_extended_life_span0.98296573
101MP0003693_abnormal_embryo_hatching0.96918365
102MP0009703_decreased_birth_body0.96328562
103MP0005167_abnormal_blood-brain_barrier0.96115502
104MP0005621_abnormal_cell_physiology0.96110760
105MP0002733_abnormal_thermal_nociception0.95602625
106MP0005646_abnormal_pituitary_gland0.94285626
107MP0000358_abnormal_cell_content/0.92820431
108MP0002084_abnormal_developmental_patter0.92739488
109MP0000647_abnormal_sebaceous_gland0.92103202
110MP0005187_abnormal_penis_morphology0.92079758
111MP0003303_peritoneal_inflammation0.90384500
112MP0004957_abnormal_blastocyst_morpholog0.90147050
113MP0005330_cardiomyopathy0.89865538
114MP0008932_abnormal_embryonic_tissue0.88787745
115MP0005388_respiratory_system_phenotype0.88657864
116MP0002133_abnormal_respiratory_system0.88657864
117MP0010368_abnormal_lymphatic_system0.87279243
118MP0002066_abnormal_motor_capabilities/c0.87184432
119MP0002972_abnormal_cardiac_muscle0.87172090
120MP0001970_abnormal_pain_threshold0.87089649
121MP0000383_abnormal_hair_follicle0.85605947
122MP0001299_abnormal_eye_distance/0.85155536
123MP0000778_abnormal_nervous_system0.85021475
124MP0002127_abnormal_cardiovascular_syste0.83872618
125MP0005384_cellular_phenotype0.83509184
126MP0010630_abnormal_cardiac_muscle0.82819248
127MP0009053_abnormal_anal_canal0.82804260
128MP0001879_abnormal_lymphatic_vessel0.82545669
129MP0002876_abnormal_thyroid_physiology0.82519042
130MP0003879_abnormal_hair_cell0.82485594
131MP0006036_abnormal_mitochondrial_physio0.82134857
132MP0005076_abnormal_cell_differentiation0.80870506
133MP0003121_genomic_imprinting0.80494348
134MP0002086_abnormal_extraembryonic_tissu0.80317200
135MP0000015_abnormal_ear_pigmentation0.78860271
136MP0000266_abnormal_heart_morphology0.78633222
137MP0000955_abnormal_spinal_cord0.77310103
138MP0001191_abnormal_skin_condition0.77296610
139MP0000350_abnormal_cell_proliferation0.77079648
140MP0008260_abnormal_autophagy0.76612625
141MP0002080_prenatal_lethality0.76364664
142MP0004085_abnormal_heartbeat0.76235211
143MP0006035_abnormal_mitochondrial_morpho0.75980791
144MP0003385_abnormal_body_wall0.74688029
145MP0000750_abnormal_muscle_regeneration0.74619949
146MP0002971_abnormal_brown_adipose0.74387744
147MP0008438_abnormal_cutaneous_collagen0.73076063
148MP0008775_abnormal_heart_ventricle0.73056803
149MP0003137_abnormal_impulse_conducting0.72688904
150MP0003890_abnormal_embryonic-extraembry0.72093450
151MP0001188_hyperpigmentation0.71710615
152MP0002152_abnormal_brain_morphology0.70673747
153MP0003111_abnormal_nucleus_morphology0.69467209
154MP0004858_abnormal_nervous_system0.68310478
155MP0002882_abnormal_neuron_morphology0.67722294
156MP0010329_abnormal_lipoprotein_level0.67339001
157MP0002557_abnormal_social/conspecific_i0.67060604
158MP0008961_abnormal_basal_metabolism0.62129777
159MP0009672_abnormal_birth_weight0.61981137
160MP0010094_abnormal_chromosome_stability0.59675870
161MP0005385_cardiovascular_system_phenoty0.58619152
162MP0001544_abnormal_cardiovascular_syste0.58619152
163MP0006276_abnormal_autonomic_nervous0.58328345
164MP0010307_abnormal_tumor_latency0.57543580
165MP0001730_embryonic_growth_arrest0.57108205

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.47695109
2Hemiplegia (HP:0002301)4.20917062
3Exercise-induced myalgia (HP:0003738)3.93853904
4Type 1 muscle fiber predominance (HP:0003803)3.88077497
5Exercise-induced muscle cramps (HP:0003710)3.82594459
6Action tremor (HP:0002345)3.78920177
7Visual hallucinations (HP:0002367)3.72178234
8Focal seizures (HP:0007359)3.65451639
9Atonic seizures (HP:0010819)3.65227280
10Microglossia (HP:0000171)3.62999243
11Amniotic constriction ring (HP:0009775)3.58178432
12Abnormality of placental membranes (HP:0011409)3.58178432
13Truncal ataxia (HP:0002078)3.55724850
14Shoulder girdle muscle weakness (HP:0003547)3.46311494
15Febrile seizures (HP:0002373)3.37176607
16Abnormality of the lower motor neuron (HP:0002366)3.29617729
17Absence seizures (HP:0002121)3.26541954
18Myokymia (HP:0002411)3.19554304
19Muscle fiber inclusion bodies (HP:0100299)3.16729029
20Long clavicles (HP:0000890)3.11930125
21Hemiparesis (HP:0001269)3.11420952
22Pelvic girdle muscle weakness (HP:0003749)3.11033614
23Poor eye contact (HP:0000817)3.11003325
24Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.10376918
25Type 2 muscle fiber atrophy (HP:0003554)3.08280549
26Dialeptic seizures (HP:0011146)3.02629758
27Dysmetric saccades (HP:0000641)3.00206175
28Parakeratosis (HP:0001036)2.97775064
29Nemaline bodies (HP:0003798)2.92169883
30Nonprogressive disorder (HP:0003680)2.89321344
31Urinary bladder sphincter dysfunction (HP:0002839)2.88172382
32Epileptic encephalopathy (HP:0200134)2.87491516
33Abnormality of the musculature of the pelvis (HP:0001469)2.78097152
34Abnormality of the hip-girdle musculature (HP:0001445)2.78097152
35Abnormality of the labia minora (HP:0012880)2.75163139
36Ventricular fibrillation (HP:0001663)2.74782042
37Fatigable weakness (HP:0003473)2.72841874
38Abnormality of the neuromuscular junction (HP:0003398)2.72841874
39Generalized tonic-clonic seizures (HP:0002069)2.67426479
40Muscle fiber atrophy (HP:0100295)2.65264274
41Cortical dysplasia (HP:0002539)2.65010905
42Abnormality of the left ventricular outflow tract (HP:0011103)2.62866569
43Subaortic stenosis (HP:0001682)2.62866569
44Excessive salivation (HP:0003781)2.62282019
45Drooling (HP:0002307)2.62282019
46Abnormal social behavior (HP:0012433)2.61215619
47Impaired social interactions (HP:0000735)2.61215619
48Fetal akinesia sequence (HP:0001989)2.60937325
49Curly hair (HP:0002212)2.56897849
50Neck muscle weakness (HP:0000467)2.56260923
51Calf muscle hypertrophy (HP:0008981)2.55146304
52Muscle hypertrophy of the lower extremities (HP:0008968)2.52118310
53Progressive cerebellar ataxia (HP:0002073)2.51326642
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.48613180
55Abnormality of skeletal muscle fiber size (HP:0012084)2.46063199
56Relative macrocephaly (HP:0004482)2.45859499
57Broad-based gait (HP:0002136)2.45806387
58Autoamputation (HP:0001218)2.44441258
59Sporadic (HP:0003745)2.42834455
60Cutaneous melanoma (HP:0012056)2.39630913
61Round ear (HP:0100830)2.38817857
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.36838186
63Depression (HP:0000716)2.36664743
64Bundle branch block (HP:0011710)2.35700101
65Resting tremor (HP:0002322)2.34603650
66Fair hair (HP:0002286)2.33942702
67Volvulus (HP:0002580)2.33912220
68Gaze-evoked nystagmus (HP:0000640)2.31059235
69Papillary thyroid carcinoma (HP:0002895)2.30244118
70Areflexia of lower limbs (HP:0002522)2.22238138
71Abnormality of the peritoneum (HP:0002585)2.22065938
72Impaired smooth pursuit (HP:0007772)2.20693200
73Mediastinal lymphadenopathy (HP:0100721)2.19564683
74Sudden death (HP:0001699)2.18883992
75Dysdiadochokinesis (HP:0002075)2.18831701
76Renal cell carcinoma (HP:0005584)2.18758304
77Impaired vibration sensation in the lower limbs (HP:0002166)2.16413833
78Mildly elevated creatine phosphokinase (HP:0008180)2.16256738
79Rhabdomyolysis (HP:0003201)2.16253072
80Myopathic facies (HP:0002058)2.16134383
81Urinary urgency (HP:0000012)2.15273772
82Back pain (HP:0003418)2.13478248
83Increased variability in muscle fiber diameter (HP:0003557)2.12812834
84Azoospermia (HP:0000027)2.12359494
85Mutism (HP:0002300)2.09695615
86Genetic anticipation (HP:0003743)2.08868600
87Lymphedema (HP:0001004)2.08077219
88Weak cry (HP:0001612)2.07817992
89Hyporeflexia of lower limbs (HP:0002600)2.07393081
90Papilledema (HP:0001085)2.06187340
91Broad ribs (HP:0000885)2.06183539
92Proximal amyotrophy (HP:0007126)2.05803904
93Difficulty running (HP:0009046)2.05077815
94EMG: myopathic abnormalities (HP:0003458)2.05019410
95Birth length less than 3rd percentile (HP:0003561)2.04909409
96Tetraplegia (HP:0002445)2.04382588
97Humeroradial synostosis (HP:0003041)2.02655779
98Synostosis involving the elbow (HP:0003938)2.02655779
99Heterotopia (HP:0002282)2.00793469
100Lower limb muscle weakness (HP:0007340)2.00584663
101Termporal pattern (HP:0011008)1.98991603
102Insidious onset (HP:0003587)1.98991603
103Inappropriate behavior (HP:0000719)1.98668547
104Myotonia (HP:0002486)1.98242132
105Albinism (HP:0001022)1.98080099
106Abnormality of the calf musculature (HP:0001430)1.96999682
107Limb-girdle muscle atrophy (HP:0003797)1.96887467
108Abnormality of ocular smooth pursuit (HP:0000617)1.96743254
109Ulnar deviation of the wrist (HP:0003049)1.95981294
110EMG: neuropathic changes (HP:0003445)1.94960622
111Atrioventricular block (HP:0001678)1.93456260
112Deep philtrum (HP:0002002)1.93354460
113Abnormal gallbladder morphology (HP:0012437)1.93244358
114Increased connective tissue (HP:0009025)1.93024538
115Rimmed vacuoles (HP:0003805)1.92700619
116Postnatal microcephaly (HP:0005484)1.91485077
117Orthostatic hypotension (HP:0001278)1.90403166
118Distal arthrogryposis (HP:0005684)1.90364953
119Cystic hygroma (HP:0000476)1.89623171
120Muscle fiber splitting (HP:0003555)1.88884375
121Bradykinesia (HP:0002067)1.88592841
122Syncope (HP:0001279)1.87816965
123Central scotoma (HP:0000603)1.87485195
124Hyperkalemia (HP:0002153)1.87483236
125Primary atrial arrhythmia (HP:0001692)1.86641304
126Difficulty climbing stairs (HP:0003551)1.86190575
127Horizontal nystagmus (HP:0000666)1.85388122
128Atrial fibrillation (HP:0005110)1.85255895
129Abnormal auditory evoked potentials (HP:0006958)1.84384631
130Cholelithiasis (HP:0001081)1.83655423
131Calcaneovalgus deformity (HP:0001848)1.82701781
132Limb-girdle muscle weakness (HP:0003325)1.79925316
133Frequent falls (HP:0002359)1.78506965
134Thyroid carcinoma (HP:0002890)1.78159695
135Myoglobinuria (HP:0002913)1.76853539
136Tetraparesis (HP:0002273)1.76384222
137Abnormality of the calcaneus (HP:0008364)1.75960968
138Overlapping toe (HP:0001845)1.75118362
139Hammertoe (HP:0001765)1.73051047
140Progressive external ophthalmoplegia (HP:0000590)1.70702814
141Right ventricular cardiomyopathy (HP:0011663)1.69414592
142Distal lower limb amyotrophy (HP:0008944)1.68555386
143Astrocytoma (HP:0009592)1.68010892
144Abnormality of the astrocytes (HP:0100707)1.68010892
145Scapular winging (HP:0003691)1.68007262
146Intrahepatic cholestasis (HP:0001406)1.67221756
147Menstrual irregularities (HP:0000858)1.66338664
148Progressive muscle weakness (HP:0003323)1.66015653
149Steppage gait (HP:0003376)1.65751444
150Spinal rigidity (HP:0003306)1.62801475
151Mitral stenosis (HP:0001718)1.60920290
152Lower limb amyotrophy (HP:0007210)1.60724098
153Muscular dystrophy (HP:0003560)1.57869623
154Hypopigmentation of the fundus (HP:0007894)1.57854195
155Freckling (HP:0001480)1.57571889
156Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.56782975
157Increased mean platelet volume (HP:0011877)1.56526034
158Arterial tortuosity (HP:0005116)1.56509868
159Breast carcinoma (HP:0003002)1.54652019
160Deformed tarsal bones (HP:0008119)1.54516522
161Large earlobe (HP:0009748)1.53191337
162Hyperglycemia (HP:0003074)1.52327509
163Delayed gross motor development (HP:0002194)1.51686816
164Vascular tortuosity (HP:0004948)1.50684816
165Pulmonic stenosis (HP:0001642)1.47477631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK7.06008671
2NEK13.67737493
3EIF2AK33.35858119
4TRIM283.32405231
5BRD43.24800356
6NTRK33.23356198
7BCR2.73172167
8CCNB12.35202137
9MAP3K92.31835210
10EPHA42.30239492
11TIE12.29026735
12SIK32.26120717
13MARK12.19635143
14EPHA32.19388109
15MAP2K72.13136497
16MAP3K42.07465828
17DAPK22.07461990
18PBK1.99634303
19MINK11.92503589
20BMPR1B1.91249721
21MAP2K41.88864252
22CAMKK11.87565026
23MST41.83437720
24LATS21.75859979
25PLK21.71924313
26LMTK21.69075698
27KSR11.63032946
28TAOK21.62090161
29PHKG21.61523786
30PHKG11.61523786
31STK38L1.48229863
32CAMKK21.47371628
33TSSK61.45106769
34MET1.45057551
35OBSCN1.41689097
36AKT31.40477208
37CASK1.39354988
38LIMK11.38966028
39BRSK11.38708443
40LATS11.35247244
41MKNK21.35078960
42STK381.33342096
43SGK21.24116862
44FRK1.22810281
45PDK41.20570206
46PDK31.20570206
47PLK31.18778581
48KSR21.18700057
49ACVR1B1.18265409
50EPHB11.17633598
51CDK81.17084961
52PNCK1.15963375
53PINK11.15289575
54CDK121.13428985
55EIF2AK11.11999963
56PAK61.11915246
57MAP3K51.09954234
58CDC71.08094033
59ERBB31.07553060
60PAK31.05813509
61PRPF4B1.04671955
62DAPK11.04399083
63TGFBR11.03798336
64WEE11.03350738
65SCYL21.03160043
66TAOK11.01267116
67SGK10.94688087
68RPS6KA40.91982969
69PKN20.91877402
70TTN0.91178931
71WNK30.90878929
72ERBB40.88083281
73MAP3K120.86503427
74SGK30.84204216
75PDK20.83639196
76CDK60.83546942
77STK100.81842550
78PRKCG0.81253253
79CSNK1A1L0.81115314
80BUB10.78776002
81MAP4K20.78414827
82NTRK20.78093066
83MAP3K20.77558315
84PIK3CG0.75446141
85STK240.74989230
86DMPK0.73645059
87TESK10.73102136
88CDK50.71748112
89TTK0.67719913
90MELK0.66333308
91PDGFRA0.66250685
92PAK40.65515186
93PLK40.65438352
94ROCK10.65163541
95PTK2B0.64869918
96IKBKB0.63680003
97NEK60.63328155
98ALK0.62675706
99CSNK1G30.62662699
100PRKCH0.62642578
101MAPKAPK30.61726917
102BRSK20.60054867
103PTK20.59382047
104MAPK130.59024828
105SGK2230.58461164
106SGK4940.58461164
107MST1R0.57998345
108MAP2K30.57446447
109SRPK10.57426863
110CSNK1G10.56670685
111PDK10.56493006
112MAP3K110.56454759
113PIM20.56319706
114ROCK20.56198238
115EIF2AK20.55900773
116YES10.55660600
117RAF10.55317341
118CSNK1D0.55042968
119MAPK120.54150822
120RET0.52901043
121MAP3K30.52664327
122CLK10.52505816
123CAMK40.52484060
124FGFR30.52000534
125MAP3K70.51964601
126PLK10.51634821
127PRKD30.51286180
128CDK90.51157349
129NEK20.51031777
130RPS6KB10.49549023
131ATM0.49135141
132PRKAA10.48444260
133IRAK30.47886326
134DYRK30.47748932
135DYRK1A0.46888070
136MAPK100.46452504
137CDK180.45671813
138RPS6KA30.44772494
139CAMK2A0.44349387
140CAMK10.38840737
141STK110.38758951
142CDK150.38664834
143CSNK1G20.38419596
144TRPM70.38042318
145MAPK70.36978185
146TGFBR20.36580531
147* CHEK10.36056310
148CAMK1G0.34982618
149PRKCE0.34680594
150RIPK40.34573848
151ZAK0.34276511
152CDK140.33892308
153AKT20.33127843
154PRKAA20.32896286
155MAP2K10.31618709
156MKNK10.31462111
157NEK90.31461052
158FER0.31035668
159CDK11A0.30929505

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.22110304
2Nicotine addiction_Homo sapiens_hsa050332.77897526
3Long-term potentiation_Homo sapiens_hsa047202.54888815
4Synaptic vesicle cycle_Homo sapiens_hsa047212.35361615
5Olfactory transduction_Homo sapiens_hsa047402.27618995
6Amphetamine addiction_Homo sapiens_hsa050312.06046474
7Circadian entrainment_Homo sapiens_hsa047132.04794273
8Glutamatergic synapse_Homo sapiens_hsa047242.02913968
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.94566460
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.92863822
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89086541
12GABAergic synapse_Homo sapiens_hsa047271.86605026
13Oxytocin signaling pathway_Homo sapiens_hsa049211.84415700
14Steroid biosynthesis_Homo sapiens_hsa001001.84118181
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73293640
16Nitrogen metabolism_Homo sapiens_hsa009101.69795438
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69699221
18Dopaminergic synapse_Homo sapiens_hsa047281.67268904
19Adherens junction_Homo sapiens_hsa045201.66996828
20Morphine addiction_Homo sapiens_hsa050321.66560237
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.62261987
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61432698
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60971864
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.57940848
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.54880055
26Insulin secretion_Homo sapiens_hsa049111.52179043
27Oocyte meiosis_Homo sapiens_hsa041141.51673560
28Circadian rhythm_Homo sapiens_hsa047101.51180884
29Cholinergic synapse_Homo sapiens_hsa047251.48400722
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47096991
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45596533
32Propanoate metabolism_Homo sapiens_hsa006401.45102767
33Fatty acid elongation_Homo sapiens_hsa000621.38459056
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38005372
35Calcium signaling pathway_Homo sapiens_hsa040201.37534566
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.36528089
37Type II diabetes mellitus_Homo sapiens_hsa049301.35671321
38Gastric acid secretion_Homo sapiens_hsa049711.35164306
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33796626
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33644847
41Vitamin B6 metabolism_Homo sapiens_hsa007501.31891756
42Renin secretion_Homo sapiens_hsa049241.31455769
43mTOR signaling pathway_Homo sapiens_hsa041501.28254468
44Long-term depression_Homo sapiens_hsa047301.27980732
45Salivary secretion_Homo sapiens_hsa049701.27707990
46Dilated cardiomyopathy_Homo sapiens_hsa054141.26926527
47GnRH signaling pathway_Homo sapiens_hsa049121.22118188
48Protein export_Homo sapiens_hsa030601.21521914
49Fatty acid metabolism_Homo sapiens_hsa012121.20777489
50Taste transduction_Homo sapiens_hsa047421.19847869
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18256905
52Pyruvate metabolism_Homo sapiens_hsa006201.17541809
53Lysine degradation_Homo sapiens_hsa003101.16164778
54Gap junction_Homo sapiens_hsa045401.15577060
55p53 signaling pathway_Homo sapiens_hsa041151.13053273
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12184573
57Insulin resistance_Homo sapiens_hsa049311.11684122
58TGF-beta signaling pathway_Homo sapiens_hsa043501.11393675
59Glucagon signaling pathway_Homo sapiens_hsa049221.09592053
60cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08618150
61FoxO signaling pathway_Homo sapiens_hsa040681.08568354
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07297377
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07023197
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03833456
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99869147
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.94899193
67Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93369986
68Glioma_Homo sapiens_hsa052140.92893143
69Tight junction_Homo sapiens_hsa045300.92026739
70Estrogen signaling pathway_Homo sapiens_hsa049150.91283664
71Pancreatic cancer_Homo sapiens_hsa052120.89427798
72MicroRNAs in cancer_Homo sapiens_hsa052060.89312382
73cAMP signaling pathway_Homo sapiens_hsa040240.89045768
74Prostate cancer_Homo sapiens_hsa052150.88681116
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88651288
76Insulin signaling pathway_Homo sapiens_hsa049100.88597726
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.88401831
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87699111
79Arginine biosynthesis_Homo sapiens_hsa002200.87677861
80Small cell lung cancer_Homo sapiens_hsa052220.87588118
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86998265
82T cell receptor signaling pathway_Homo sapiens_hsa046600.86929463
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86278544
84Shigellosis_Homo sapiens_hsa051310.85953300
85Focal adhesion_Homo sapiens_hsa045100.85865973
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85003079
87Chronic myeloid leukemia_Homo sapiens_hsa052200.84612507
88Proteoglycans in cancer_Homo sapiens_hsa052050.84182780
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83993690
90Basal transcription factors_Homo sapiens_hsa030220.83138854
91Endometrial cancer_Homo sapiens_hsa052130.82673177
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.81905956
93Hippo signaling pathway_Homo sapiens_hsa043900.80884598
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80216674
95Biosynthesis of amino acids_Homo sapiens_hsa012300.80074519
96B cell receptor signaling pathway_Homo sapiens_hsa046620.79745313
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79137662
98Dorso-ventral axis formation_Homo sapiens_hsa043200.78474019
99ErbB signaling pathway_Homo sapiens_hsa040120.75897842
100Legionellosis_Homo sapiens_hsa051340.74854717
101RNA transport_Homo sapiens_hsa030130.74661216
102MAPK signaling pathway_Homo sapiens_hsa040100.74401541
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73283735
104Cocaine addiction_Homo sapiens_hsa050300.70335126
105Nucleotide excision repair_Homo sapiens_hsa034200.68792142
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.67680289
107Cardiac muscle contraction_Homo sapiens_hsa042600.67436535
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67219888
109Inositol phosphate metabolism_Homo sapiens_hsa005620.66883694
110Arginine and proline metabolism_Homo sapiens_hsa003300.65965886
111Serotonergic synapse_Homo sapiens_hsa047260.65566586
112HIF-1 signaling pathway_Homo sapiens_hsa040660.65233002
113Carbon metabolism_Homo sapiens_hsa012000.64842069
114Base excision repair_Homo sapiens_hsa034100.62643063
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62493477
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.61537412
117Fructose and mannose metabolism_Homo sapiens_hsa000510.60792613
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.59963125
119Regulation of autophagy_Homo sapiens_hsa041400.57021369
120Vibrio cholerae infection_Homo sapiens_hsa051100.55679902
121Prion diseases_Homo sapiens_hsa050200.55320177
122mRNA surveillance pathway_Homo sapiens_hsa030150.55255039
123Thyroid cancer_Homo sapiens_hsa052160.54758191
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.54463368
125Pentose phosphate pathway_Homo sapiens_hsa000300.53621412
126VEGF signaling pathway_Homo sapiens_hsa043700.53084179
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52858638
128Colorectal cancer_Homo sapiens_hsa052100.52843197
129Sphingolipid metabolism_Homo sapiens_hsa006000.52534742
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51516558
131Hepatitis C_Homo sapiens_hsa051600.51464775
132Fanconi anemia pathway_Homo sapiens_hsa034600.50295098
133Hepatitis B_Homo sapiens_hsa051610.49507847
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49365908
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47872121
136Melanogenesis_Homo sapiens_hsa049160.47871606
137Fatty acid degradation_Homo sapiens_hsa000710.46332093
138Viral carcinogenesis_Homo sapiens_hsa052030.46250605
139Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45115594
140Butanoate metabolism_Homo sapiens_hsa006500.43802814
141Endocytosis_Homo sapiens_hsa041440.43783829
142AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43551247
143Non-small cell lung cancer_Homo sapiens_hsa052230.42301444
144Thyroid hormone synthesis_Homo sapiens_hsa049180.41981228
145Proteasome_Homo sapiens_hsa030500.40959562
146AMPK signaling pathway_Homo sapiens_hsa041520.40867535
147Caffeine metabolism_Homo sapiens_hsa002320.40502362
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.40484410
149Choline metabolism in cancer_Homo sapiens_hsa052310.40142061
150Chemokine signaling pathway_Homo sapiens_hsa040620.37446202
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.35433304
152Renal cell carcinoma_Homo sapiens_hsa052110.35175774
153Cell cycle_Homo sapiens_hsa041100.34148830
154Prolactin signaling pathway_Homo sapiens_hsa049170.30663345
155Pancreatic secretion_Homo sapiens_hsa049720.30530486
156PPAR signaling pathway_Homo sapiens_hsa033200.30373276

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