ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	4.97416415
2	nuclear pore organization (GO:0006999)	4.90788541
3	mitotic metaphase plate congression (GO:0007080)	4.84153693
4	actin-myosin filament sliding (GO:0033275)	4.45900079
5	muscle filament sliding (GO:0030049)	4.45900079
6	mitotic chromosome condensation (GO:0007076)	4.12153183
7	sarcoplasmic reticulum calcium ion transport (GO:0070296)	4.11308506
8	protein localization to kinetochore (GO:0034501)	4.08979248
9	mitotic nuclear envelope disassembly (GO:0007077)	4.08491604
10	actin-mediated cell contraction (GO:0070252)	4.04845303
11	metaphase plate congression (GO:0051310)	4.03544834
12	mitotic sister chromatid cohesion (GO:0007064)	4.01250702
13	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.00658254
14	establishment of chromosome localization (GO:0051303)	3.98048161
15	membrane disassembly (GO:0030397)	3.96430920
16	nuclear envelope disassembly (GO:0051081)	3.96430920
17	regulation of centriole replication (GO:0046599)	3.85263660
18	regulation of helicase activity (GO:0051095)	3.73489254
19	histone H2A monoubiquitination (GO:0035518)	3.66422127
20	monoubiquitinated protein deubiquitination (GO:0035520)	3.62602679
21	pore complex assembly (GO:0046931)	3.61936591
22	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.58986155
23	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.58986155
24	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.58986155
25	regulation of spindle organization (GO:0090224)	3.56142629
26	IMP metabolic process (GO:0046040)	3.53986166
27	folic acid-containing compound biosynthetic process (GO:0009396)	3.52895509
28	sister chromatid segregation (GO:0000819)	3.49260294
29	mitotic sister chromatid segregation (GO:0000070)	3.47555690
30	meiotic chromosome segregation (GO:0045132)	3.46990447
31	IMP biosynthetic process (GO:0006188)	3.46927780
32	pre-miRNA processing (GO:0031054)	3.45482096
33	regulation of sister chromatid cohesion (GO:0007063)	3.42962451
34	regulation of translational termination (GO:0006449)	3.40638242
35	positive regulation of chromosome segregation (GO:0051984)	3.36100480
36	protein localization to chromosome, centromeric region (GO:0071459)	3.35122747
37	DNA replication-dependent nucleosome organization (GO:0034723)	3.33176574
38	DNA replication-dependent nucleosome assembly (GO:0006335)	3.33176574
39	regulation of mitotic spindle organization (GO:0060236)	3.32254073
40	DNA unwinding involved in DNA replication (GO:0006268)	3.27671702
41	regulation of centrosome cycle (GO:0046605)	3.21698019
42	attachment of spindle microtubules to kinetochore (GO:0008608)	3.21553702
43	cellular response to interferon-alpha (GO:0035457)	3.13668507
44	positive regulation of interferon-alpha production (GO:0032727)	3.07416110
45	actin filament-based movement (GO:0030048)	3.06635661
46	protein localization to chromosome (GO:0034502)	3.03087665
47	nuclear envelope organization (GO:0006998)	3.01060852
48	regulation of relaxation of muscle (GO:1901077)	3.00716604
49	regulation of chromosome segregation (GO:0051983)	2.99417758
50	regulation of mitotic metaphase/anaphase transition (GO:0030071)	2.98110063
51	spindle checkpoint (GO:0031577)	2.97821310
52	ventricular cardiac muscle cell development (GO:0055015)	2.97729282
53	chromatin remodeling at centromere (GO:0031055)	2.96458897
54	positive regulation of translational initiation (GO:0045948)	2.96105128
55	chromosome segregation (GO:0007059)	2.94741962
56	cardiac muscle cell development (GO:0055013)	2.93688990
57	tricarboxylic acid cycle (GO:0006099)	2.93499790
58	CENP-A containing nucleosome assembly (GO:0034080)	2.93345392
59	notochord development (GO:0030903)	2.93117932
60	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.91914994
61	positive regulation by symbiont of host defense response (GO:0052509)	2.91342433
62	modulation by symbiont of host defense response (GO:0052031)	2.91342433
63	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.91342433
64	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.91342433
65	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.91342433
66	modulation by symbiont of host immune response (GO:0052553)	2.91342433
67	sarcomere organization (GO:0045214)	2.90322242
68	skeletal muscle contraction (GO:0003009)	2.90203255
69	regulation of RIG-I signaling pathway (GO:0039535)	2.89395108
70	corticosteroid receptor signaling pathway (GO:0031958)	2.88628188
71	establishment of integrated proviral latency (GO:0075713)	2.88284319
72	regulation of interferon-alpha production (GO:0032647)	2.87855801
73	negative regulation of histone methylation (GO:0031061)	2.82540783
74	histone H2A ubiquitination (GO:0033522)	2.81960238
75	response to muscle activity (GO:0014850)	2.80756743
76	regulation of T-helper 1 cell differentiation (GO:0045625)	2.80665736
77	regulation of RNA export from nucleus (GO:0046831)	2.79632506
78	ribosome assembly (GO:0042255)	2.79448715
79	heterochromatin organization (GO:0070828)	2.79138195
80	regulation of skeletal muscle contraction (GO:0014819)	2.79125028
81	skeletal muscle adaptation (GO:0043501)	2.78702425
82	cardiac cell development (GO:0055006)	2.76923457
83	paraxial mesoderm development (GO:0048339)	2.76559937
84	regulation of sister chromatid segregation (GO:0033045)	2.76356042
85	regulation of mitotic sister chromatid separation (GO:0010965)	2.76356042
86	regulation of mitotic sister chromatid segregation (GO:0033047)	2.76356042
87	mitotic spindle checkpoint (GO:0071174)	2.76157373
88	spindle assembly checkpoint (GO:0071173)	2.75798346
89	mitotic spindle assembly checkpoint (GO:0007094)	2.74498473
90	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.73559130
91	negative regulation of sister chromatid segregation (GO:0033046)	2.73559130
92	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.73559130
93	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.73559130
94	negative regulation of chromosome segregation (GO:0051985)	2.73172572
95	positive regulation of protein import into nucleus, translocation (GO:0033160)	2.72599079
96	natural killer cell mediated cytotoxicity (GO:0042267)	2.72075095
97	natural killer cell mediated immunity (GO:0002228)	2.72075095
98	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.72030056
99	regulation of centrosome duplication (GO:0010824)	2.71864538
100	postreplication repair (GO:0006301)	2.70486197
101	DNA replication initiation (GO:0006270)	2.70068855
102	kinetochore organization (GO:0051383)	2.69791237
103	cytoskeleton-dependent cytokinesis (GO:0061640)	2.69408865
104	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.66264067
105	protein K6-linked ubiquitination (GO:0085020)	2.66216651
106	sister chromatid cohesion (GO:0007062)	2.65328454
107	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	2.65183928
108	glucocorticoid receptor signaling pathway (GO:0042921)	2.62642043
109	negative regulation by host of viral transcription (GO:0043922)	2.62214426
110	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.61942935
111	DNA replication-independent nucleosome assembly (GO:0006336)	2.61800377
112	DNA replication-independent nucleosome organization (GO:0034724)	2.61800377
113	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.61739819
114	histone exchange (GO:0043486)	2.61297685
115	cullin deneddylation (GO:0010388)	2.61109305
116	regulation of cofactor metabolic process (GO:0051193)	2.61039820
117	regulation of coenzyme metabolic process (GO:0051196)	2.61039820
118	regulation of telomere maintenance via telomerase (GO:0032210)	2.60048334
119	positive regulation of interferon-beta production (GO:0032728)	2.57032146
120	mismatch repair (GO:0006298)	2.56061680
121	DNA geometric change (GO:0032392)	2.55987437
122	peptidyl-arginine N-methylation (GO:0035246)	2.55820731
123	peptidyl-arginine methylation (GO:0018216)	2.55820731
124	myofibril assembly (GO:0030239)	2.54705883
125	DNA duplex unwinding (GO:0032508)	2.54584195
126	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.54500933
127	regulation of sarcomere organization (GO:0060297)	2.51185074
128	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	2.47535993
129	microtubule depolymerization (GO:0007019)	2.46246434
130	DNA damage response, detection of DNA damage (GO:0042769)	2.45297639
131	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.44654035
132	mitotic spindle organization (GO:0007052)	2.42288470
133	skeletal muscle fiber development (GO:0048741)	2.39877689
134	cardiac myofibril assembly (GO:0055003)	2.39473906
135	regulation of DNA endoreduplication (GO:0032875)	2.33949757
136	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	2.33066010
137	otic vesicle formation (GO:0030916)	2.32536021
138	striated muscle cell development (GO:0055002)	2.31915215
139	mitotic G2/M transition checkpoint (GO:0044818)	2.29655952
140	negative regulation of DNA recombination (GO:0045910)	2.29330036
141	regulation of cell communication by electrical coupling (GO:0010649)	2.28760432
142	microtubule anchoring (GO:0034453)	2.28587648
143	myotube cell development (GO:0014904)	2.27487051
144	muscle fiber development (GO:0048747)	2.26549491
145	striated muscle contraction (GO:0006941)	2.25343887
146	DNA double-strand break processing (GO:0000729)	2.25293769
147	actomyosin structure organization (GO:0031032)	2.23293605
148	cellular protein complex localization (GO:0034629)	2.21842926
149	negative regulation of microtubule depolymerization (GO:0007026)	2.21814259
150	acrosome assembly (GO:0001675)	2.20827757
151	cholesterol biosynthetic process (GO:0006695)	2.20572025
152	regulation of microtubule depolymerization (GO:0031114)	2.18940990
153	aspartate family amino acid catabolic process (GO:0009068)	2.16551866

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	5.71962373
2	EGR1_19374776_ChIP-ChIP_THP-1_Human	4.40616890
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.14262562
4	* KDM5B_21448134_ChIP-Seq_MESCs_Mouse	3.36518430
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.19361200
6	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	3.10762563
7	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.05165934
8	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.92695883
9	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.86958556
10	AR_21909140_ChIP-Seq_LNCAP_Human	2.54381245
11	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.53697715
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.48801774
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.14568112
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.14271684
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.09053218
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.08545163
17	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.04397907
18	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.02637959
19	E2F7_22180533_ChIP-Seq_HELA_Human	10.6619689
20	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.97966573
21	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97676434
22	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.97093279
23	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.96395717
24	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.92507397
25	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.89581851
26	SALL4_18804426_ChIP-ChIP_MESCs_Mouse	1.89509488
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87046254
28	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.86161189
29	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.84696866
30	GBX2_23144817_ChIP-Seq_PC3_Human	1.84313530
31	* MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.76491475
32	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.71640617
33	TAF15_26573619_Chip-Seq_HEK293_Human	1.68480130
34	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.67401297
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.66743317
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65467494
37	* ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.62041361
38	* P300_19829295_ChIP-Seq_ESCs_Human	1.59792621
39	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57225993
40	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.52982847
41	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.46080287
42	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.45795899
43	MYC_22102868_ChIP-Seq_BL_Human	1.45326910
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.44524880
45	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.38454223
46	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.38428883
47	VDR_22108803_ChIP-Seq_LS180_Human	1.37802692
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.37109839
49	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.33611012
50	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33301503
51	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	1.32929670
52	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.32078045
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31990152
54	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	1.31895360
55	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.30112742
56	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.29726520
57	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28840331
58	* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.28734384
59	FUS_26573619_Chip-Seq_HEK293_Human	1.27375998
60	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.26872828
61	ZNF274_21170338_ChIP-Seq_K562_Hela	1.26600710
62	* CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25855365
63	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25652155
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24588142
65	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.24040181
66	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.23641422
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23514372
68	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.23425727
69	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.23380121
70	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.22393898
71	TFEB_21752829_ChIP-Seq_HELA_Human	1.22345590
72	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.21848834
73	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.20847265
74	* VDR_23849224_ChIP-Seq_CD4+_Human	1.19310916
75	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.19155284
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18123137
77	CBP_20019798_ChIP-Seq_JUKART_Human	1.18123137
78	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.17645241
79	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.16748174
80	* NANOG_16153702_ChIP-ChIP_HESCs_Human	1.16673442
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16515093
82	SMAD4_21799915_ChIP-Seq_A2780_Human	1.16068144
83	XRN2_22483619_ChIP-Seq_HELA_Human	1.15671310
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.15595395
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14989361
86	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.14056942
87	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.14025978
88	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.10968847
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.10931967
90	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.10031535
91	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09785244
92	KDM5A_27292631_Chip-Seq_BREAST_Human	1.09500659
93	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.08459866
94	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.08398428
95	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.08311733
96	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.07298876
97	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.06911367
98	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.06262484
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.05810634
100	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.05628670
101	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05181882
102	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.05065691
103	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04781951
104	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.02843022
105	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.02711983
106	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01849072
107	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.01456357
108	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.01040164
109	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00918351
110	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.00841942
111	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.00546643
112	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.00374753
113	SOX9_26525672_Chip-Seq_HEART_Mouse	1.00312953
114	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.99821385
115	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.98027293
116	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97140705
117	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.96086391
118	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.95872665
119	STAT3_23295773_ChIP-Seq_U87_Human	0.95361831
120	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.95360430
121	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.95331646
122	NANOG_18347094_ChIP-ChIP_MESCs_Mouse	0.95123914
123	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.94942366
124	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94828196
125	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.94823391
126	BRD4_25478319_ChIP-Seq_HGPS_Human	0.94780084
127	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.93553553
128	* SOX17_20123909_ChIP-Seq_XEN_Mouse	0.93346195
129	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.92959036
130	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.92436405
131	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.92381701
132	MYC_18940864_ChIP-ChIP_HL60_Human	0.91870142
133	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.91826487
134	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.91826487
135	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.91499586
136	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90656700
137	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90656700
138	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.90514581
139	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.89480470
140	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.88349840
141	EWS_26573619_Chip-Seq_HEK293_Human	0.86260202
142	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.86206732
143	DCP1A_22483619_ChIP-Seq_HELA_Human	0.85595344
144	* THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.83355673
145	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.81685469
146	GABP_19822575_ChIP-Seq_HepG2_Human	0.80910551
147	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.80228897
148	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.78521849
149	ATF3_27146783_Chip-Seq_COLON_Human	0.77735952
150	TTF2_22483619_ChIP-Seq_HELA_Human	0.77116692
151	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.75981416
152	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.75856650
153	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.74420425
154	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.73655445
155	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.72392596
156	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.72357068
157	* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.72222346
158	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.72020221
159	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.71327820
160	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.71238475

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003693_abnormal_embryo_hatching	3.38653794
2	MP0010094_abnormal_chromosome_stability	3.32802326
3	MP0008057_abnormal_DNA_replication	3.30783156
4	MP0005076_abnormal_cell_differentiation	3.06941604
5	MP0010352_gastrointestinal_tract_polyps	3.05824404
6	MP0010307_abnormal_tumor_latency	3.04535360
7	MP0000751_myopathy	3.02453793
8	MP0003646_muscle_fatigue	2.99726200
9	MP0003077_abnormal_cell_cycle	2.97666691
10	MP0004957_abnormal_blastocyst_morpholog	2.94322289
11	MP0003111_abnormal_nucleus_morphology	2.82461186
12	MP0003123_paternal_imprinting	2.62696739
13	MP0003941_abnormal_skin_development	2.32396134
14	MP0000350_abnormal_cell_proliferation	2.27958893
15	MP0008007_abnormal_cellular_replicative	2.14248865
16	MP0008877_abnormal_DNA_methylation	2.11287000
17	MP0001730_embryonic_growth_arrest	2.09229140
18	MP0003705_abnormal_hypodermis_morpholog	2.06821679
19	MP0002877_abnormal_melanocyte_morpholog	1.99167353
20	MP0003890_abnormal_embryonic-extraembry	1.99129889
21	MP0010030_abnormal_orbit_morphology	1.98277838
22	MP0009697_abnormal_copulation	1.92971764
23	MP0008058_abnormal_DNA_repair	1.87663573
24	MP0009780_abnormal_chondrocyte_physiolo	1.87026968
25	MP0001299_abnormal_eye_distance/	1.86036208
26	MP0003950_abnormal_plasma_membrane	1.82036833
27	MP0004215_abnormal_myocardial_fiber	1.76232923
28	MP0003136_yellow_coat_color	1.74417685
29	MP0003303_peritoneal_inflammation	1.69822775
30	MP0001835_abnormal_antigen_presentation	1.68662716
31	MP0008932_abnormal_embryonic_tissue	1.68324322
32	MP0010234_abnormal_vibrissa_follicle	1.64054395
33	MP0001697_abnormal_embryo_size	1.63353673
34	MP0001348_abnormal_lacrimal_gland	1.56947101
35	MP0005380_embryogenesis_phenotype	1.56646040
36	MP0001672_abnormal_embryogenesis/_devel	1.56646040
37	MP0005620_abnormal_muscle_contractility	1.56413661
38	MP0008789_abnormal_olfactory_epithelium	1.55426134
39	MP0001915_intracranial_hemorrhage	1.50938226
40	MP0001293_anophthalmia	1.50713912
41	MP0003448_altered_tumor_morphology	1.46741440
42	MP0003121_genomic_imprinting	1.46267471
43	MP0002084_abnormal_developmental_patter	1.46141946
44	MP0000733_abnormal_muscle_development	1.46027241
45	MP0003984_embryonic_growth_retardation	1.45041380
46	MP0001529_abnormal_vocalization	1.43343214
47	MP0002233_abnormal_nose_morphology	1.43303630
48	MP0003937_abnormal_limbs/digits/tail_de	1.43111303
49	MP0002088_abnormal_embryonic_growth/wei	1.41445788
50	MP0003787_abnormal_imprinting	1.38823649
51	MP0004270_analgesia	1.38465420
52	MP0002086_abnormal_extraembryonic_tissu	1.35854993
53	MP0004510_myositis	1.35184087
54	MP0003718_maternal_effect	1.33180945
55	MP0003755_abnormal_palate_morphology	1.32601476
56	MP0006292_abnormal_olfactory_placode	1.32243459
57	MP0009785_altered_susceptibility_to	1.30453585
58	MP0004233_abnormal_muscle_weight	1.30329104
59	MP0002085_abnormal_embryonic_tissue	1.29678384
60	MP0004197_abnormal_fetal_growth/weight/	1.29452032
61	MP0006082_CNS_inflammation	1.27422404
62	MP0002972_abnormal_cardiac_muscle	1.25427497
63	MP0004145_abnormal_muscle_electrophysio	1.20676495
64	MP0002080_prenatal_lethality	1.20488040
65	MP0006276_abnormal_autonomic_nervous	1.20439866
66	MP0003122_maternal_imprinting	1.17967803
67	MP0000569_abnormal_digit_pigmentation	1.17464014
68	MP0000049_abnormal_middle_ear	1.16976966
69	MP0002106_abnormal_muscle_physiology	1.14325224
70	MP0005330_cardiomyopathy	1.14048863
71	MP0003566_abnormal_cell_adhesion	1.14043103
72	MP0000778_abnormal_nervous_system	1.12815799
73	MP0003385_abnormal_body_wall	1.11799288
74	MP0005621_abnormal_cell_physiology	1.11078891
75	MP0002396_abnormal_hematopoietic_system	1.10506159
76	MP0003221_abnormal_cardiomyocyte_apopto	1.09375376
77	MP0002653_abnormal_ependyma_morphology	1.08176270
78	MP0003436_decreased_susceptibility_to	1.08064167
79	MP0003091_abnormal_cell_migration	1.06112933
80	MP0002019_abnormal_tumor_incidence	1.05769508
81	MP0000372_irregular_coat_pigmentation	1.05228411
82	MP0001286_abnormal_eye_development	1.03858592
83	MP0005187_abnormal_penis_morphology	1.01564657
84	MP0009250_abnormal_appendicular_skeleto	1.00053759
85	MP0006138_congestive_heart_failure	0.99320377
86	MP0005397_hematopoietic_system_phenotyp	0.98977750
87	MP0001545_abnormal_hematopoietic_system	0.98977750
88	MP0006036_abnormal_mitochondrial_physio	0.98139020
89	MP0002006_tumorigenesis	0.97713121
90	MP0000313_abnormal_cell_death	0.97667277
91	MP0000750_abnormal_muscle_regeneration	0.97492828
92	MP0000685_abnormal_immune_system	0.96260674
93	MP0004808_abnormal_hematopoietic_stem	0.95966899
94	MP0004272_abnormal_basement_membrane	0.95914470
95	MP0002148_abnormal_hypersensitivity_rea	0.95725629
96	MP0002332_abnormal_exercise_endurance	0.95497951
97	MP0000647_abnormal_sebaceous_gland	0.95314651
98	MP0002697_abnormal_eye_size	0.95033793
99	MP0005394_taste/olfaction_phenotype	0.94861641
100	MP0005499_abnormal_olfactory_system	0.94861641
101	MP0002127_abnormal_cardiovascular_syste	0.93937986
102	MP0002269_muscular_atrophy	0.92891036
103	MP0001188_hyperpigmentation	0.92755918
104	MP0005000_abnormal_immune_tolerance	0.92659854
105	MP0004087_abnormal_muscle_fiber	0.92625271
106	MP0010368_abnormal_lymphatic_system	0.91328647
107	MP0005384_cellular_phenotype	0.90966734
108	MP0005248_abnormal_Harderian_gland	0.90722501
109	MP0000762_abnormal_tongue_morphology	0.90250757
110	MP0002163_abnormal_gland_morphology	0.89102030
111	MP0009672_abnormal_birth_weight	0.88338762
112	MP0002108_abnormal_muscle_morphology	0.88087547
113	MP0003935_abnormal_craniofacial_develop	0.87562933
114	MP0001984_abnormal_olfaction	0.86385633
115	MP0002398_abnormal_bone_marrow	0.86080277
116	MP0003119_abnormal_digestive_system	0.85862590
117	MP0002938_white_spotting	0.84175391
118	MP0005623_abnormal_meninges_morphology	0.83788429
119	MP0005367_renal/urinary_system_phenotyp	0.83065360
120	MP0000516_abnormal_urinary_system	0.83065360
121	MP0003861_abnormal_nervous_system	0.82473243
122	MP0002452_abnormal_antigen_presenting	0.80861010
123	MP0002837_dystrophic_cardiac_calcinosis	0.79713351
124	MP0006035_abnormal_mitochondrial_morpho	0.79457896
125	MP0004084_abnormal_cardiac_muscle	0.79205223
126	MP0002092_abnormal_eye_morphology	0.79113739
127	MP0005671_abnormal_response_to	0.79016371
128	MP0004085_abnormal_heartbeat	0.78708184
129	MP0009053_abnormal_anal_canal	0.78344654
130	MP0002177_abnormal_outer_ear	0.78289816
131	MP0004858_abnormal_nervous_system	0.77760789
132	MP0006072_abnormal_retinal_apoptosis	0.77562191
133	MP0000759_abnormal_skeletal_muscle	0.77246549
134	MP0005385_cardiovascular_system_phenoty	0.76935395
135	MP0001544_abnormal_cardiovascular_syste	0.76935395
136	MP0002081_perinatal_lethality	0.76638234
137	MP0002102_abnormal_ear_morphology	0.76555079
138	MP0001849_ear_inflammation	0.76536053
139	MP0001346_abnormal_lacrimal_gland	0.75477024
140	MP0000749_muscle_degeneration	0.74926920
141	MP0010630_abnormal_cardiac_muscle	0.74756417
142	MP0001800_abnormal_humoral_immune	0.73874507
143	MP0005369_muscle_phenotype	0.71811220
144	MP0004036_abnormal_muscle_relaxation	0.70892996
145	MP0000858_altered_metastatic_potential	0.70001752
146	MP0001119_abnormal_female_reproductive	0.69873700
147	MP0002723_abnormal_immune_serum	0.68582734
148	MP0003567_abnormal_fetal_cardiomyocyte	0.68574063
149	MP0008775_abnormal_heart_ventricle	0.68479711
150	MP0000343_altered_response_to	0.67138324
151	MP0000627_abnormal_mammary_gland	0.66348556
152	MP0009333_abnormal_splenocyte_physiolog	0.62361278
153	MP0009703_decreased_birth_body	0.62246704
154	MP0000747_muscle_weakness	0.61565757
155	MP0002925_abnormal_cardiovascular_devel	0.61430655

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Exercise-induced myalgia (HP:0003738)	4.15508813
2	Abnormality of the labia minora (HP:0012880)	3.87082011
3	Papillary thyroid carcinoma (HP:0002895)	3.82562575
4	Shoulder girdle muscle weakness (HP:0003547)	3.80351645
5	Muscle fiber inclusion bodies (HP:0100299)	3.68331062
6	Muscle hypertrophy of the lower extremities (HP:0008968)	3.60691880
7	Pelvic girdle muscle weakness (HP:0003749)	3.59217416
8	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	3.57305441
9	Cortical dysplasia (HP:0002539)	3.51669960
10	Exercise-induced muscle cramps (HP:0003710)	3.45750934
11	Nemaline bodies (HP:0003798)	3.42786776
12	Agnosia (HP:0010524)	3.42212828
13	Birth length less than 3rd percentile (HP:0003561)	3.31076183
14	Calf muscle hypertrophy (HP:0008981)	3.30234620
15	Abnormality of the left ventricular outflow tract (HP:0011103)	3.22105611
16	Subaortic stenosis (HP:0001682)	3.22105611
17	Abnormality of the hip-girdle musculature (HP:0001445)	3.19639311
18	Abnormality of the musculature of the pelvis (HP:0001469)	3.19639311
19	Ulnar deviation of the wrist (HP:0003049)	3.12337578
20	Abnormality of the calf musculature (HP:0001430)	3.10916221
21	EMG: myopathic abnormalities (HP:0003458)	2.91734740
22	Disinhibition (HP:0000734)	2.87306830
23	Facial hemangioma (HP:0000329)	2.77355462
24	Chromsome breakage (HP:0040012)	2.75257496
25	Round ear (HP:0100830)	2.68325216
26	Biliary tract neoplasm (HP:0100574)	2.68017539
27	Neck muscle weakness (HP:0000467)	2.64187309
28	Medulloblastoma (HP:0002885)	2.61077086
29	Centrally nucleated skeletal muscle fibers (HP:0003687)	2.60886295
30	Limb-girdle muscle atrophy (HP:0003797)	2.49564162
31	Cutaneous melanoma (HP:0012056)	2.47869352
32	Thyroid carcinoma (HP:0002890)	2.47269744
33	Patellar aplasia (HP:0006443)	2.46283054
34	Frequent falls (HP:0002359)	2.40389816
35	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.40375953
36	Spinal rigidity (HP:0003306)	2.35979534
37	Abnormality of the calcaneus (HP:0008364)	2.34380408
38	Inappropriate behavior (HP:0000719)	2.34082527
39	Myoglobinuria (HP:0002913)	2.31909707
40	Ependymoma (HP:0002888)	2.31482141
41	Colon cancer (HP:0003003)	2.31316059
42	Myotonia (HP:0002486)	2.30449872
43	Calcaneovalgus deformity (HP:0001848)	2.30126485
44	Rhabdomyolysis (HP:0003201)	2.30101068
45	Abnormality of the astrocytes (HP:0100707)	2.24957603
46	Astrocytoma (HP:0009592)	2.24957603
47	Aplasia/Hypoplasia of the patella (HP:0006498)	2.23787044
48	Transitional cell carcinoma of the bladder (HP:0006740)	2.20166434
49	Apathy (HP:0000741)	2.19196086
50	Bladder neoplasm (HP:0009725)	2.17890486
51	Bladder carcinoma (HP:0002862)	2.17890486
52	Distal arthrogryposis (HP:0005684)	2.13580884
53	Muscle fiber splitting (HP:0003555)	2.12383594
54	Muscle stiffness (HP:0003552)	2.11748732
55	Malignant gastrointestinal tract tumors (HP:0006749)	2.11611473
56	Gastrointestinal carcinoma (HP:0002672)	2.11611473
57	Increased density of long bones (HP:0006392)	2.09645719
58	Abnormality of chromosome stability (HP:0003220)	2.04794954
59	Wrist flexion contracture (HP:0001239)	2.03145840
60	Deformed tarsal bones (HP:0008119)	2.02278791
61	Cleft eyelid (HP:0000625)	2.01755738
62	Acute myeloid leukemia (HP:0004808)	2.01739710
63	Uterine leiomyosarcoma (HP:0002891)	2.01496275
64	Leiomyosarcoma (HP:0100243)	2.01496275
65	Absent eyebrow (HP:0002223)	2.01293946
66	Abnormality of skeletal muscle fiber size (HP:0012084)	2.00500489
67	Neoplasm of the small intestine (HP:0100833)	2.00480341
68	Uterine neoplasm (HP:0010784)	2.00290247
69	Hyporeflexia of lower limbs (HP:0002600)	1.99850179
70	Pheochromocytoma (HP:0002666)	1.97146746
71	Degeneration of anterior horn cells (HP:0002398)	1.96746004
72	Abnormality of the anterior horn cell (HP:0006802)	1.96746004
73	Diminished motivation (HP:0000745)	1.93664786
74	Hereditary nonpolyposis colorectal carcinoma (HP:0006716)	1.93268516
75	Volvulus (HP:0002580)	1.92317844
76	Cafe-au-lait spot (HP:0000957)	1.91630105
77	Rhabdomyosarcoma (HP:0002859)	1.90542310
78	Bundle branch block (HP:0011710)	1.89433531
79	Long clavicles (HP:0000890)	1.87803887
80	Rimmed vacuoles (HP:0003805)	1.87350943
81	Short 4th metacarpal (HP:0010044)	1.87053811
82	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.87053811
83	Sandal gap (HP:0001852)	1.87022808
84	Upper motor neuron abnormality (HP:0002127)	1.86675522
85	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.86570085
86	Abnormality of the shoulder girdle musculature (HP:0001435)	1.86535145
87	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.86484511
88	Proximal amyotrophy (HP:0007126)	1.85055807
89	Difficulty running (HP:0009046)	1.83885300
90	Abnormality of the metopic suture (HP:0005556)	1.83870182
91	Abnormal finger flexion creases (HP:0006143)	1.83858079
92	Neoplasm of the oral cavity (HP:0100649)	1.83685935
93	Abnormal lung lobation (HP:0002101)	1.82307687
94	Autoimmune thrombocytopenia (HP:0001973)	1.81824035
95	Abnormality of chromosome segregation (HP:0002916)	1.81715372
96	Neuroendocrine neoplasm (HP:0100634)	1.81576804
97	Termporal pattern (HP:0011008)	1.80624790
98	Insidious onset (HP:0003587)	1.80624790
99	Slender build (HP:0001533)	1.79618241
100	Ectopic kidney (HP:0000086)	1.78820006
101	Mildly elevated creatine phosphokinase (HP:0008180)	1.78484813
102	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.75517602
103	Absent phalangeal crease (HP:0006109)	1.75353645
104	Microglossia (HP:0000171)	1.74694500
105	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.73823413
106	Neoplasm of the rectum (HP:0100743)	1.70487599
107	Myopathic facies (HP:0002058)	1.69593368
108	Subacute progressive viral hepatitis (HP:0006572)	1.69399675
109	Amaurosis fugax (HP:0100576)	1.69199099
110	Scapular winging (HP:0003691)	1.68767039
111	Supernumerary spleens (HP:0009799)	1.68722050
112	Distal lower limb muscle weakness (HP:0009053)	1.68496369
113	Type 1 muscle fiber predominance (HP:0003803)	1.67755537
114	Limb dystonia (HP:0002451)	1.67733241
115	Capillary hemangiomas (HP:0005306)	1.67293720
116	Sudden death (HP:0001699)	1.67239385
117	Cystic hygroma (HP:0000476)	1.67168973
118	Increased serum pyruvate (HP:0003542)	1.66613091
119	Hip contracture (HP:0003273)	1.66345322
120	Porencephaly (HP:0002132)	1.66176509
121	Prominent metopic ridge (HP:0005487)	1.65981497
122	Poor head control (HP:0002421)	1.65049724
123	Intellectual disability, profound (HP:0002187)	1.64568752
124	Malignant hyperthermia (HP:0002047)	1.64409023
125	Fused cervical vertebrae (HP:0002949)	1.64015611
126	Areflexia of lower limbs (HP:0002522)	1.63853807
127	Amyotrophic lateral sclerosis (HP:0007354)	1.62527846
128	Abnormality of the fingertips (HP:0001211)	1.61395699
129	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.61379933
130	Abnormality of glycolysis (HP:0004366)	1.61217431
131	Prostate neoplasm (HP:0100787)	1.61025467
132	Broad thumb (HP:0011304)	1.60782590
133	Cutis marmorata (HP:0000965)	1.58758741
134	Hypoalphalipoproteinemia (HP:0003233)	1.58528863
135	Personality changes (HP:0000751)	1.58366967
136	Eczematoid dermatitis (HP:0000976)	1.58088667
137	Glioma (HP:0009733)	1.57923642
138	Increased connective tissue (HP:0009025)	1.57244943
139	Limb-girdle muscle weakness (HP:0003325)	1.57061533
140	Absent radius (HP:0003974)	1.56809743
141	Nephroblastoma (Wilms tumor) (HP:0002667)	1.56625263
142	Retrobulbar optic neuritis (HP:0100654)	1.56412757
143	Optic neuritis (HP:0100653)	1.56412757
144	Myelodysplasia (HP:0002863)	1.56302017
145	Intestinal atresia (HP:0011100)	1.53950857
146	Bifid tongue (HP:0010297)	1.53458624
147	Embryonal renal neoplasm (HP:0011794)	1.53004360
148	Neoplasm of the peripheral nervous system (HP:0100007)	1.52175171
149	Increased variability in muscle fiber diameter (HP:0003557)	1.50842269
150	Delayed gross motor development (HP:0002194)	1.47536854
151	Multiple enchondromatosis (HP:0005701)	1.46428716
152	Hepatoblastoma (HP:0002884)	1.46221737
153	Muscular dystrophy (HP:0003560)	1.43152127
154	Optic nerve hypoplasia (HP:0000609)	1.42788680
155	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.41893148
156	EMG: neuropathic changes (HP:0003445)	1.41552864
157	Dilated cardiomyopathy (HP:0001644)	1.40025624
158	Neoplasm of the adrenal gland (HP:0100631)	1.38891926
159	Drooling (HP:0002307)	1.37543193
160	Lower limb amyotrophy (HP:0007210)	1.36705281
161	Limited hip movement (HP:0008800)	1.36198052
162	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.35755867
163	Webbed neck (HP:0000465)	1.34985772
164	Hyperalaninemia (HP:0003348)	1.33311613
165	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.33311613
166	Abnormality of alanine metabolism (HP:0010916)	1.33311613
167	Absent septum pellucidum (HP:0001331)	1.31701337
168	Neoplasm of the colon (HP:0100273)	1.30971424

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	3.88678894
2	NEK1	3.20125760
3	KSR2	2.76895528
4	TRIM28	2.72922935
5	MAP3K9	2.62459361
6	LATS2	2.51967630
7	LATS1	2.51572872
8	SCYL2	2.47406219
9	PLK4	2.28486361
10	PLK2	2.27121840
11	PHKG1	2.11917550
12	PHKG2	2.11917550
13	PLK3	2.02644828
14	PBK	1.94950032
15	ERBB3	1.90702960
16	MAP3K13	1.85213090
17	CDK12	1.84347882
18	TTK	1.84054840
19	MST4	1.82475104
20	PNCK	1.79033169
21	KSR1	1.77010168
22	EIF2AK1	1.76505421
23	ERBB4	1.75977304
24	MKNK2	1.67664171
25	NEK2	1.67177892
26	TNIK	1.64329390
27	WNK3	1.62718918
28	MAP3K14	1.62077511
29	TTN	1.60167734
30	EEF2K	1.56556630
31	NEK9	1.55264602
32	CASK	1.47036917
33	STK3	1.45423046
34	JAK3	1.42048198
35	TSSK6	1.41474493
36	RAF1	1.40936571
37	CCNB1	1.39496404
38	ACVR1B	1.35490661
39	RPS6KA4	1.34824944
40	PLK1	1.33912322
41	STK38L	1.30045976
42	BRAF	1.26410178
43	SRPK1	1.25395114
44	LIMK1	1.24506218
45	WEE1	1.23363481
46	MAP3K5	1.21015902
47	MAP3K8	1.20902397
48	TAF1	1.17738131
49	PDK2	1.16233625
50	MAP3K12	1.16126239
51	PINK1	1.14212019
52	ALK	1.13992411
53	CHEK1	1.13345704
54	MAP3K4	1.12703810
55	ATR	1.10413641
56	TYK2	1.06743471
57	MAP3K6	1.02330962
58	ARAF	0.95920026
59	CHEK2	0.95632210
60	PKN2	0.95459315
61	CDK6	0.94312879
62	BRSK2	0.93229070
63	MELK	0.93111427
64	ATM	0.90960834
65	MARK1	0.89661335
66	CSNK1G1	0.89530356
67	STK10	0.89499836
68	NUAK1	0.88543919
69	TESK1	0.83992732
70	PAK3	0.83234023
71	BCR	0.83091203
72	PASK	0.82488415
73	OBSCN	0.82411850
74	AURKB	0.82249708
75	CSNK1G2	0.80480068
76	PAK6	0.79109809
77	BMPR1B	0.78511089
78	CSNK1G3	0.76797840
79	MKNK1	0.76115967
80	CDK4	0.73580908
81	PIK3CG	0.73337694
82	FRK	0.73155318
83	EIF2AK3	0.72103634
84	CHUK	0.71875594
85	BRD4	0.71547290
86	STK39	0.70781970
87	CDK2	0.69897378
88	RET	0.69601966
89	MAP2K7	0.68202205
90	STK4	0.67220918
91	MAP2K4	0.66722755
92	TIE1	0.66549107
93	CSNK1A1L	0.65143994
94	BRSK1	0.63830148
95	STK24	0.62295085
96	BMX	0.61341747
97	ABL2	0.60977699
98	CDK1	0.60872612
99	DYRK2	0.60395655
100	CDK19	0.60279765
101	STK16	0.60138089
102	FGFR1	0.60088975
103	TBK1	0.59801314
104	RIPK4	0.58210177
105	MINK1	0.57398026
106	DYRK3	0.57319191
107	BUB1	0.56851013
108	MAP3K10	0.56155407
109	MOS	0.55670248
110	EPHB2	0.53918635
111	AKT2	0.53894192
112	CSNK1E	0.53842736
113	RPS6KB2	0.53495356
114	PRKD3	0.50153424
115	MUSK	0.49875053
116	JAK2	0.49786017
117	DAPK1	0.49587526
118	CDK11A	0.49557036
119	TAOK1	0.46784815
120	FGFR3	0.46553005
121	CDK7	0.45985725
122	CAMK2A	0.45675284
123	TRPM7	0.45508843
124	TYRO3	0.45149042
125	MAPK10	0.44824654
126	CLK1	0.44764690
127	CAMK2D	0.44454087
128	ROCK1	0.44297848
129	CDK14	0.44147272
130	AURKA	0.43356272
131	CSNK1D	0.42641443
132	VRK2	0.42350329
133	SIK3	0.42305862
134	MAPK13	0.42266478
135	JAK1	0.41209788
136	VRK1	0.40018005
137	DMPK	0.38878231
138	TGFBR1	0.38397212
139	EIF2AK2	0.38305684
140	PDGFRA	0.38245198
141	CDK18	0.37429420
142	OXSR1	0.37159405
143	PIM1	0.35778255
144	IKBKB	0.34993369
145	ROCK2	0.34926942
146	CAMK2G	0.34188280
147	CDK15	0.34090453
148	FGR	0.32452863

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.79778017
2	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.46079319
3	Cell cycle_Homo sapiens_hsa04110	2.43744513
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.37559734
5	RNA transport_Homo sapiens_hsa03013	2.15064741
6	Steroid biosynthesis_Homo sapiens_hsa00100	2.10534714
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.01650618
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.01123962
9	Propanoate metabolism_Homo sapiens_hsa00640	1.93045164
10	Graft-versus-host disease_Homo sapiens_hsa05332	1.91816866
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.84514904
12	Allograft rejection_Homo sapiens_hsa05330	1.79657241
13	DNA replication_Homo sapiens_hsa03030	1.79593903
14	Mismatch repair_Homo sapiens_hsa03430	1.79403277
15	Protein export_Homo sapiens_hsa03060	1.70949694
16	Legionellosis_Homo sapiens_hsa05134	1.69345486
17	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.63360958
18	RNA degradation_Homo sapiens_hsa03018	1.61379458
19	Viral myocarditis_Homo sapiens_hsa05416	1.58509135
20	Pyruvate metabolism_Homo sapiens_hsa00620	1.57186654
21	One carbon pool by folate_Homo sapiens_hsa00670	1.56345622
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56236165
23	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.53704824
24	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.51972799
25	TNF signaling pathway_Homo sapiens_hsa04668	1.51654594
26	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47508124
27	Leishmaniasis_Homo sapiens_hsa05140	1.47174415
28	Herpes simplex infection_Homo sapiens_hsa05168	1.47129407
29	Carbon metabolism_Homo sapiens_hsa01200	1.46380941
30	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.44256597
31	Oocyte meiosis_Homo sapiens_hsa04114	1.43975705
32	Influenza A_Homo sapiens_hsa05164	1.43612888
33	p53 signaling pathway_Homo sapiens_hsa04115	1.43418329
34	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.40053968
35	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.39954119
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.34156537
37	Fatty acid elongation_Homo sapiens_hsa00062	1.33038810
38	mTOR signaling pathway_Homo sapiens_hsa04150	1.31895542
39	mRNA surveillance pathway_Homo sapiens_hsa03015	1.30665423
40	Viral carcinogenesis_Homo sapiens_hsa05203	1.30461760
41	Arginine and proline metabolism_Homo sapiens_hsa00330	1.29977172
42	Proteasome_Homo sapiens_hsa03050	1.29907319
43	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.29904122
44	Spliceosome_Homo sapiens_hsa03040	1.29746179
45	Circadian rhythm_Homo sapiens_hsa04710	1.29245807
46	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.26701218
47	Hepatitis B_Homo sapiens_hsa05161	1.25591915
48	MicroRNAs in cancer_Homo sapiens_hsa05206	1.21102172
49	Tight junction_Homo sapiens_hsa04530	1.20566139
50	Colorectal cancer_Homo sapiens_hsa05210	1.20328086
51	Measles_Homo sapiens_hsa05162	1.20308586
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19275132
53	Antigen processing and presentation_Homo sapiens_hsa04612	1.19046898
54	Base excision repair_Homo sapiens_hsa03410	1.16235953
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16016981
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.14958314
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.14123908
58	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.12912669
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.11941304
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.10377724
61	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.09796333
62	Shigellosis_Homo sapiens_hsa05131	1.09306166
63	Pancreatic cancer_Homo sapiens_hsa05212	1.09149411
64	Parkinsons disease_Homo sapiens_hsa05012	1.07716727
65	Homologous recombination_Homo sapiens_hsa03440	1.06871649
66	Tuberculosis_Homo sapiens_hsa05152	1.05221706
67	Apoptosis_Homo sapiens_hsa04210	1.03877073
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.03827480
69	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.02394938
70	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.02089748
71	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.01940318
72	Huntingtons disease_Homo sapiens_hsa05016	0.98387265
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.97732915
74	Toxoplasmosis_Homo sapiens_hsa05145	0.97232524
75	Prolactin signaling pathway_Homo sapiens_hsa04917	0.96784689
76	HTLV-I infection_Homo sapiens_hsa05166	0.96387986
77	Non-homologous end-joining_Homo sapiens_hsa03450	0.95123890
78	Renal cell carcinoma_Homo sapiens_hsa05211	0.94603095
79	Pertussis_Homo sapiens_hsa05133	0.92427018
80	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92239043
81	Salmonella infection_Homo sapiens_hsa05132	0.91818556
82	Thyroid cancer_Homo sapiens_hsa05216	0.89932019
83	Rheumatoid arthritis_Homo sapiens_hsa05323	0.89862799
84	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.89044727
85	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88940753
86	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.88761562
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.87614205
88	Adherens junction_Homo sapiens_hsa04520	0.87075487
89	Osteoclast differentiation_Homo sapiens_hsa04380	0.86978080
90	Purine metabolism_Homo sapiens_hsa00230	0.85929540
91	Glioma_Homo sapiens_hsa05214	0.85439463
92	Small cell lung cancer_Homo sapiens_hsa05222	0.84617960
93	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.84103421
94	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.84074290
95	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.84010036
96	FoxO signaling pathway_Homo sapiens_hsa04068	0.83206947
97	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.81550866
98	Endometrial cancer_Homo sapiens_hsa05213	0.81485035
99	Wnt signaling pathway_Homo sapiens_hsa04310	0.81391547
100	Chemokine signaling pathway_Homo sapiens_hsa04062	0.80957061
101	Type II diabetes mellitus_Homo sapiens_hsa04930	0.79251589
102	RNA polymerase_Homo sapiens_hsa03020	0.78846975
103	Basal transcription factors_Homo sapiens_hsa03022	0.77530869
104	Lysine degradation_Homo sapiens_hsa00310	0.76999784
105	Hippo signaling pathway_Homo sapiens_hsa04390	0.75276993
106	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73152635
107	Fatty acid metabolism_Homo sapiens_hsa01212	0.72677592
108	Asthma_Homo sapiens_hsa05310	0.70347961
109	Gap junction_Homo sapiens_hsa04540	0.68995028
110	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.68469860
111	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.67773970
112	ECM-receptor interaction_Homo sapiens_hsa04512	0.67756758
113	Proteoglycans in cancer_Homo sapiens_hsa05205	0.66799687
114	Fatty acid degradation_Homo sapiens_hsa00071	0.66428650
115	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.65617421
116	Basal cell carcinoma_Homo sapiens_hsa05217	0.64834162
117	Butanoate metabolism_Homo sapiens_hsa00650	0.64776268
118	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.64507098
119	Glucagon signaling pathway_Homo sapiens_hsa04922	0.64451266
120	Tryptophan metabolism_Homo sapiens_hsa00380	0.64352254
121	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.63983401
122	Fanconi anemia pathway_Homo sapiens_hsa03460	0.63691956
123	VEGF signaling pathway_Homo sapiens_hsa04370	0.63488586
124	Non-small cell lung cancer_Homo sapiens_hsa05223	0.63175014
125	Phagosome_Homo sapiens_hsa04145	0.63027733
126	Axon guidance_Homo sapiens_hsa04360	0.62807839
127	Folate biosynthesis_Homo sapiens_hsa00790	0.62555956
128	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61907753
129	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.61562848
130	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.61440188
131	Malaria_Homo sapiens_hsa05144	0.61272638
132	Pentose phosphate pathway_Homo sapiens_hsa00030	0.60472472
133	Oxidative phosphorylation_Homo sapiens_hsa00190	0.59797746
134	ErbB signaling pathway_Homo sapiens_hsa04012	0.59666061
135	Alzheimers disease_Homo sapiens_hsa05010	0.59401328
136	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.57778373
137	Caffeine metabolism_Homo sapiens_hsa00232	0.57464186
138	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.55461244
139	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.54390551
140	African trypanosomiasis_Homo sapiens_hsa05143	0.54015133
141	Long-term potentiation_Homo sapiens_hsa04720	0.53592384
142	MAPK signaling pathway_Homo sapiens_hsa04010	0.53437630
143	Melanoma_Homo sapiens_hsa05218	0.53216096
144	Amoebiasis_Homo sapiens_hsa05146	0.53178300
145	Calcium signaling pathway_Homo sapiens_hsa04020	0.50379176
146	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50365444
147	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50251634
148	Hepatitis C_Homo sapiens_hsa05160	0.49783271
149	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.48398025
150	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.48124248
151	Pyrimidine metabolism_Homo sapiens_hsa00240	0.47968021
152	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.47632954
153	Selenocompound metabolism_Homo sapiens_hsa00450	0.47576460
154	Focal adhesion_Homo sapiens_hsa04510	0.46266082
155	Insulin signaling pathway_Homo sapiens_hsa04910	0.45663692
156	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.44446838
157	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.43905317
158	Dopaminergic synapse_Homo sapiens_hsa04728	0.40979690
159	Long-term depression_Homo sapiens_hsa04730	0.40617849
160	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.39089531
161	Regulation of autophagy_Homo sapiens_hsa04140	0.38772202
162	Glutathione metabolism_Homo sapiens_hsa00480	0.38293368
163	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.37549123
164	Metabolic pathways_Homo sapiens_hsa01100	0.37223670
165	Sulfur metabolism_Homo sapiens_hsa00920	0.36572361
166	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.36529395

KPNA3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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