KPNA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.17405904
2muscle filament sliding (GO:0030049)5.17405904
3actin-mediated cell contraction (GO:0070252)4.66862275
4sarcoplasmic reticulum calcium ion transport (GO:0070296)4.65906006
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.15369857
6nuclear pore complex assembly (GO:0051292)4.10114530
7cytoplasmic mRNA processing body assembly (GO:0033962)3.94396696
8actin filament-based movement (GO:0030048)3.82188122
9regulation of interleukin-12 biosynthetic process (GO:0045075)3.79104093
10positive regulation of gamma-delta T cell activation (GO:0046645)3.74221991
11sarcomere organization (GO:0045214)3.69925227
12growth hormone receptor signaling pathway (GO:0060396)3.69634837
13mitotic sister chromatid cohesion (GO:0007064)3.68918837
14cellular protein complex localization (GO:0034629)3.60658299
15negative regulation of cell killing (GO:0031342)3.59606754
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.59606754
17skeletal muscle contraction (GO:0003009)3.55883469
18nuclear pore organization (GO:0006999)3.54594961
19plasma membrane repair (GO:0001778)3.45061806
20myofibril assembly (GO:0030239)3.28025762
21negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.27147397
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.21882818
23regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21752550
24regulation of relaxation of muscle (GO:1901077)3.20054433
25response to muscle activity (GO:0014850)3.19118049
26negative regulation of DNA repair (GO:0045738)3.13766836
27regulation of gamma-delta T cell differentiation (GO:0045586)3.11156579
28cellular response to growth hormone stimulus (GO:0071378)3.09824007
29cardiac muscle cell development (GO:0055013)3.09813982
30ribosome assembly (GO:0042255)3.09004778
31paraxial mesoderm development (GO:0048339)3.08949948
32SMAD protein complex assembly (GO:0007183)3.05916615
33protein localization to microtubule (GO:0035372)3.05575757
34anterior/posterior axis specification, embryo (GO:0008595)3.04967271
35regulation of NFAT protein import into nucleus (GO:0051532)3.03607499
36protein complex localization (GO:0031503)3.03053527
37notochord development (GO:0030903)3.00720384
38negative T cell selection (GO:0043383)3.00256048
39hepatocyte apoptotic process (GO:0097284)3.00037896
40negative thymic T cell selection (GO:0045060)2.99433392
41pore complex assembly (GO:0046931)2.98985861
42* NLS-bearing protein import into nucleus (GO:0006607)2.98233624
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.97250898
44regulation of transforming growth factor beta2 production (GO:0032909)2.96804395
45actomyosin structure organization (GO:0031032)2.96506319
46cardiac cell development (GO:0055006)2.95669859
47modulation by symbiont of host defense response (GO:0052031)2.94795205
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94795205
49modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94795205
50positive regulation by organism of defense response of other organism involved in symbiotic interact2.94795205
51modulation by symbiont of host immune response (GO:0052553)2.94795205
52positive regulation by symbiont of host defense response (GO:0052509)2.94795205
53cell adhesion mediated by integrin (GO:0033627)2.91886791
54IMP metabolic process (GO:0046040)2.91365198
55regulation of gamma-delta T cell activation (GO:0046643)2.90974965
56mitotic chromosome condensation (GO:0007076)2.90362575
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.90083079
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90083079
59mitotic metaphase plate congression (GO:0007080)2.86516923
60regulation of Rac protein signal transduction (GO:0035020)2.85893885
61pre-miRNA processing (GO:0031054)2.85394865
62JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84650167
63antigen processing and presentation of endogenous antigen (GO:0019883)2.84378721
64positive regulation of interferon-alpha production (GO:0032727)2.83230641
65mRNA stabilization (GO:0048255)2.82535558
66RNA stabilization (GO:0043489)2.82535558
67cardiac myofibril assembly (GO:0055003)2.82083100
68embryonic foregut morphogenesis (GO:0048617)2.82051059
69positive thymic T cell selection (GO:0045059)2.80795654
70hemidesmosome assembly (GO:0031581)2.80616818
71response to inactivity (GO:0014854)2.80111748
72regulation of interferon-alpha production (GO:0032647)2.76293424
73regulation of skeletal muscle contraction (GO:0014819)2.75361271
74substrate-dependent cell migration (GO:0006929)2.75157137
75negative regulation of potassium ion transmembrane transport (GO:1901380)2.74163316
76negative regulation of fibroblast apoptotic process (GO:2000270)2.73177336
77striated muscle contraction (GO:0006941)2.72731534
78response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.72545159
79regulation of interferon-beta biosynthetic process (GO:0045357)2.68673468
80cell migration involved in sprouting angiogenesis (GO:0002042)2.65719612
81regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.64147070
82regulation of RNA export from nucleus (GO:0046831)2.63961323
83positive regulation of natural killer cell differentiation (GO:0032825)2.62765527
84negative regulation of keratinocyte proliferation (GO:0010839)2.61758406
85regulation of T cell tolerance induction (GO:0002664)2.60920851
86metaphase plate congression (GO:0051310)2.59403418
87positive regulation of histone deacetylation (GO:0031065)2.57420220
88monoubiquitinated protein deubiquitination (GO:0035520)2.55758055
89hippo signaling (GO:0035329)2.55622008
90positive regulation of mitotic sister chromatid separation (GO:1901970)2.54694592
91positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54694592
92positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54694592
93thymic T cell selection (GO:0045061)2.54034902
94cell-substrate junction assembly (GO:0007044)2.53554087
95embryonic process involved in female pregnancy (GO:0060136)2.53271842
96skeletal muscle fiber development (GO:0048741)2.52627939
97positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.51511215
98skeletal muscle adaptation (GO:0043501)2.51506576
99iron ion import (GO:0097286)2.50229018
100COPII vesicle coating (GO:0048208)2.49296320
101sister chromatid segregation (GO:0000819)2.48923058
102I-kappaB phosphorylation (GO:0007252)2.48215744
103positive regulation of chromosome segregation (GO:0051984)2.48025199
104establishment of chromosome localization (GO:0051303)2.47682106
105response to X-ray (GO:0010165)2.44479462
106germ cell migration (GO:0008354)2.43986721
107regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.43945180
108regulation of nucleobase-containing compound transport (GO:0032239)2.43111764
109positive regulation of p38MAPK cascade (GO:1900745)2.41801719
110cardiac muscle hypertrophy (GO:0003300)2.41559868
111cellular extravasation (GO:0045123)2.40315752
112UDP-N-acetylglucosamine metabolic process (GO:0006047)2.39368568
113T cell selection (GO:0045058)2.38287392
114muscle contraction (GO:0006936)2.37518692
115bundle of His cell to Purkinje myocyte communication (GO:0086069)2.37170996
116negative regulation of anoikis (GO:2000811)2.37093649
117regulation of cAMP-dependent protein kinase activity (GO:2000479)2.36766318
118muscle cell cellular homeostasis (GO:0046716)2.36539194
119natural killer cell differentiation (GO:0001779)2.36242315
120positive T cell selection (GO:0043368)2.36161507
121focal adhesion assembly (GO:0048041)2.36041247
122cell-substrate adherens junction assembly (GO:0007045)2.36041247
123adherens junction assembly (GO:0034333)2.35231657
124regulation of translational termination (GO:0006449)2.34471050
125positive regulation of catenin import into nucleus (GO:0035413)2.34110933
126histone-serine phosphorylation (GO:0035404)2.33926564
127adult heart development (GO:0007512)2.32460953
128regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.32426883
129negative regulation of fatty acid transport (GO:2000192)2.32357662
130establishment of endothelial barrier (GO:0061028)2.30817957
1313-UTR-mediated mRNA stabilization (GO:0070935)2.30780735
132cellular response to interferon-alpha (GO:0035457)2.29511580
133membrane disassembly (GO:0030397)2.29251038
134nuclear envelope disassembly (GO:0051081)2.29251038
135regulation of protein export from nucleus (GO:0046825)2.28682877
136corticosteroid receptor signaling pathway (GO:0031958)2.28615191
137negative regulation of B cell proliferation (GO:0030889)2.28452427
138regulation of B cell receptor signaling pathway (GO:0050855)2.28365157
139regulation of actin filament-based movement (GO:1903115)2.27779437
140retina vasculature morphogenesis in camera-type eye (GO:0061299)2.27654016
141pericardium development (GO:0060039)2.27548126
142regulation of mitotic spindle organization (GO:0060236)2.27503650
143mammary gland epithelial cell proliferation (GO:0033598)2.26492894
144positive regulation of protein import into nucleus, translocation (GO:0033160)2.26062443
145striated muscle hypertrophy (GO:0014897)2.25648264
146chondrocyte development (GO:0002063)2.25509343
147regulation of mRNA stability (GO:0043488)2.25359426
148myotube cell development (GO:0014904)2.25128100
149striated muscle cell development (GO:0055002)2.24474927
150mitotic nuclear envelope disassembly (GO:0007077)2.23337114
151artery development (GO:0060840)2.23126758
152tolerance induction (GO:0002507)2.23035286
153NIK/NF-kappaB signaling (GO:0038061)2.22633162
154negative regulation of interleukin-12 production (GO:0032695)2.21834395
155regulation of tolerance induction (GO:0002643)2.21637319
156regulation of protein polyubiquitination (GO:1902914)2.17992489
157positive regulation of mRNA catabolic process (GO:0061014)2.17833186
158myeloid dendritic cell differentiation (GO:0043011)2.17748124
159positive regulation of immune response to tumor cell (GO:0002839)2.17698717
160regulation of immune response to tumor cell (GO:0002837)2.17698717
161regulation of response to tumor cell (GO:0002834)2.17698717
162positive regulation of response to tumor cell (GO:0002836)2.17698717
163protein localization to endosome (GO:0036010)2.17511273
164histone H3-K9 demethylation (GO:0033169)2.17255886
165glucocorticoid receptor signaling pathway (GO:0042921)2.15897782
166positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.15880968
167macrophage activation involved in immune response (GO:0002281)2.15412557
168regulation of DNA endoreduplication (GO:0032875)2.14291569
169regulation of dendritic cell antigen processing and presentation (GO:0002604)2.13865663
170regulation of RNA stability (GO:0043487)2.12935475
171positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.11606919
172histone mRNA catabolic process (GO:0071044)2.10669913
173response to interleukin-15 (GO:0070672)2.10518111
174endothelial tube morphogenesis (GO:0061154)2.10413360
175morphogenesis of an endothelium (GO:0003159)2.10413360
176positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.10026463
177T cell costimulation (GO:0031295)2.10013926
178leukocyte aggregation (GO:0070486)2.08951401
179leukocyte cell-cell adhesion (GO:0007159)2.08578730
180positive regulation of interleukin-2 production (GO:0032743)2.08362304
181regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.08221153
182Arp2/3 complex-mediated actin nucleation (GO:0034314)2.08103536
183myeloid dendritic cell activation (GO:0001773)2.08008524
184regulation of interleukin-12 production (GO:0032655)2.07719676
185tyrosine phosphorylation of STAT protein (GO:0007260)2.06600703
186response to laminar fluid shear stress (GO:0034616)2.05710837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29791593
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.95354800
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.92133407
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83224229
5E2F7_22180533_ChIP-Seq_HELA_Human3.47674757
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.47437192
7WT1_19549856_ChIP-ChIP_CCG9911_Human2.96618660
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.86696512
9AR_21909140_ChIP-Seq_LNCAP_Human2.67692465
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47445757
11MYC_22102868_ChIP-Seq_BL_Human2.44637070
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39565260
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.38812782
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.30382794
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.23005816
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22039411
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21192957
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21057102
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.20082594
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07687547
21* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.06203929
22RUNX_20019798_ChIP-Seq_JUKART_Human2.06156682
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.04871946
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02747182
25EP300_21415370_ChIP-Seq_HL-1_Mouse1.98076722
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.94391781
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.90075044
28* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88476438
29MYB_26560356_Chip-Seq_TH2_Human1.88465146
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.88462684
31MAF_26560356_Chip-Seq_TH1_Human1.87086160
32CLOCK_20551151_ChIP-Seq_293T_Human1.84573347
33BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81484968
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81245157
35BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79590324
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75686306
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75145263
38HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.72541516
39MYB_26560356_Chip-Seq_TH1_Human1.71813018
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71601839
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68770950
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68770950
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.66561290
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.63278767
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.62461133
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60656691
47KDM2B_26808549_Chip-Seq_DND41_Human1.60264257
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60020557
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57987622
50FOXO3_23340844_ChIP-Seq_DLD1_Human1.56601181
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56301118
52* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53010016
53* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53010016
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.52233371
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.51771861
56UTX_26944678_Chip-Seq_JUKART_Human1.50272717
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47100165
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46731333
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45925893
60NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.44392387
61BRD4_25478319_ChIP-Seq_HGPS_Human1.44290365
62STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43608566
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42103755
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40335066
65PU_27001747_Chip-Seq_BMDM_Mouse1.37406992
66RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34942745
67MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.34740312
68FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34054914
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30727243
70KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28829132
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28808119
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28239810
73VDR_21846776_ChIP-Seq_THP-1_Human1.27897126
74CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27590823
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25039464
76GATA4_21415370_ChIP-Seq_HL-1_Mouse1.24399663
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.24370818
78GATA3_27048872_Chip-Seq_THYMUS_Human1.24210127
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24113831
80RUNX1_22412390_ChIP-Seq_EML_Mouse1.23876598
81SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23344843
82SPI1_23127762_ChIP-Seq_K562_Human1.23028130
83* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.22795355
84SCL_19346495_ChIP-Seq_HPC-7_Human1.22333105
85GATA2_21666600_ChIP-Seq_HMVEC_Human1.22121016
86VDR_24763502_ChIP-Seq_THP-1_Human1.21032573
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.19364980
88VDR_24787735_ChIP-Seq_THP-1_Human1.18884204
89CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18544818
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17619666
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16932691
92* ELK1_19687146_ChIP-ChIP_HELA_Human1.16616038
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15557335
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.14268557
95* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13790613
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13771655
97FUS_26573619_Chip-Seq_HEK293_Human1.13174177
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13126043
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.11934208
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11478356
101* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11267901
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09713406
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.09186909
104ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08056958
105TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06949638
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.06285396
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04866942
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04771852
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.04683645
110* CHD1_26751641_Chip-Seq_LNCaP_Human1.04393972
111TBX20_22328084_ChIP-Seq_HEART_Mouse1.04362124
112TBX20_22080862_ChIP-Seq_HEART_Mouse1.04362124
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.03976886
114NCOR1_26117541_ChIP-Seq_K562_Human1.03342173
115PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02970630
116MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02950419
117* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02396166
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02123592
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01297730
120TAF15_26573619_Chip-Seq_HEK293_Human1.01039545
121FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00013073
122EZH2_27294783_Chip-Seq_NPCs_Mouse0.99916730
123CJUN_26792858_Chip-Seq_BT549_Human0.99809515
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99687613
125PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98966679
126TP53_18474530_ChIP-ChIP_U2OS_Human0.98515025
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97156738
128E2F1_18555785_Chip-Seq_ESCs_Mouse0.96600177
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96060333
130RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95805841
131* SPI1_23547873_ChIP-Seq_NB4_Human0.95301590
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95295943
133NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95126124
134NANOG_18555785_Chip-Seq_ESCs_Mouse0.94527338
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93966105
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93965331
137P300_19829295_ChIP-Seq_ESCs_Human0.93344694
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93320486
139TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93042774
140PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92887560
141SMAD4_21799915_ChIP-Seq_A2780_Human0.92728300
142SOX17_20123909_ChIP-Seq_XEN_Mouse0.92705395
143MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92642794
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92465833
145NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92100180
146SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91712952
147ATF3_27146783_Chip-Seq_COLON_Human0.91460440
148* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91180923
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.90301118
150TP53_16413492_ChIP-PET_HCT116_Human0.90069178
151GATA6_25053715_ChIP-Seq_YYC3_Human0.89878018
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89725773
153TRIM28_21343339_ChIP-Seq_HEK293_Human0.89523084
154RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88945624
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88648490
156ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88416143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.68400189
2MP0010352_gastrointestinal_tract_polyps3.65724384
3MP0000749_muscle_degeneration3.18038231
4MP0003705_abnormal_hypodermis_morpholog3.15044916
5MP0003300_gastrointestinal_ulcer3.12961517
6MP0000751_myopathy3.09755061
7MP0003941_abnormal_skin_development3.02788232
8MP0000569_abnormal_digit_pigmentation2.93525802
9MP0005076_abnormal_cell_differentiation2.87380258
10MP0003303_peritoneal_inflammation2.76025489
11MP0003646_muscle_fatigue2.56120907
12MP0004036_abnormal_muscle_relaxation2.43267289
13MP0002166_altered_tumor_susceptibility2.40566008
14MP0001835_abnormal_antigen_presentation2.22637200
15MP0002006_tumorigenesis2.22617664
16MP0004233_abnormal_muscle_weight2.22420002
17MP0000747_muscle_weakness2.19026954
18MP0003566_abnormal_cell_adhesion2.11768895
19MP0004145_abnormal_muscle_electrophysio2.05643034
20MP0004808_abnormal_hematopoietic_stem2.03523042
21MP0003436_decreased_susceptibility_to1.99220916
22MP0002269_muscular_atrophy1.97597482
23MP0000759_abnormal_skeletal_muscle1.95763243
24MP0000733_abnormal_muscle_development1.95011117
25MP0010307_abnormal_tumor_latency1.89419179
26MP0009278_abnormal_bone_marrow1.85763129
27MP0003221_abnormal_cardiomyocyte_apopto1.82237072
28MP0010234_abnormal_vibrissa_follicle1.80341094
29MP0002106_abnormal_muscle_physiology1.79354066
30MP0000685_abnormal_immune_system1.79296236
31MP0003091_abnormal_cell_migration1.78775808
32MP0003890_abnormal_embryonic-extraembry1.77337296
33MP0002332_abnormal_exercise_endurance1.70862293
34MP0005620_abnormal_muscle_contractility1.70164908
35MP0004947_skin_inflammation1.66720430
36MP0001800_abnormal_humoral_immune1.64751455
37MP0005387_immune_system_phenotype1.64524403
38MP0001790_abnormal_immune_system1.64524403
39MP0003448_altered_tumor_morphology1.62860428
40MP0004510_myositis1.62815289
41MP0004957_abnormal_blastocyst_morpholog1.60719563
42MP0002452_abnormal_antigen_presenting1.58221642
43MP0005000_abnormal_immune_tolerance1.57115617
44MP0002396_abnormal_hematopoietic_system1.54507368
45MP0002877_abnormal_melanocyte_morpholog1.54315573
46MP0005451_abnormal_body_composition1.53592700
47MP0005671_abnormal_response_to1.53588971
48MP0002972_abnormal_cardiac_muscle1.53354250
49MP0005369_muscle_phenotype1.50159917
50MP0003763_abnormal_thymus_physiology1.47393536
51MP0004215_abnormal_myocardial_fiber1.47163875
52MP0003045_fibrosis1.44767352
53MP0000750_abnormal_muscle_regeneration1.44190249
54MP0008438_abnormal_cutaneous_collagen1.43248338
55MP0001853_heart_inflammation1.42676493
56MP0005330_cardiomyopathy1.42571353
57MP0004185_abnormal_adipocyte_glucose1.42339238
58MP0009785_altered_susceptibility_to1.40954135
59MP0006138_congestive_heart_failure1.40448964
60MP0001545_abnormal_hematopoietic_system1.38833396
61MP0005397_hematopoietic_system_phenotyp1.38833396
62MP0002723_abnormal_immune_serum1.38702625
63MP0002138_abnormal_hepatobiliary_system1.38563070
64MP0002419_abnormal_innate_immunity1.38295010
65MP0004130_abnormal_muscle_cell1.37574220
66MP0003828_pulmonary_edema1.36343725
67MP0001819_abnormal_immune_cell1.35203874
68MP0002398_abnormal_bone_marrow1.34805383
69MP0002420_abnormal_adaptive_immunity1.34698136
70MP0002009_preneoplasia1.34573225
71MP0005023_abnormal_wound_healing1.32861052
72MP0000762_abnormal_tongue_morphology1.32831849
73MP0010678_abnormal_skin_adnexa1.29778885
74MP0005257_abnormal_intraocular_pressure1.28749010
75MP0009672_abnormal_birth_weight1.27744580
76MP0001299_abnormal_eye_distance/1.26521923
77MP0002405_respiratory_system_inflammati1.26396162
78MP0010155_abnormal_intestine_physiology1.26185223
79MP0000579_abnormal_nail_morphology1.25218963
80MP0005025_abnormal_response_to1.25047551
81MP0005623_abnormal_meninges_morphology1.22357320
82MP0001730_embryonic_growth_arrest1.21639380
83MP0004484_altered_response_of1.21071537
84MP0005248_abnormal_Harderian_gland1.19420133
85MP0009697_abnormal_copulation1.19136762
86MP0000858_altered_metastatic_potential1.17253061
87MP0005275_abnormal_skin_tensile1.17138112
88MP0003453_abnormal_keratinocyte_physiol1.15403123
89MP0006082_CNS_inflammation1.13931530
90MP0003077_abnormal_cell_cycle1.13678318
91MP0000428_abnormal_craniofacial_morphol1.13029995
92MP0000716_abnormal_immune_system1.12882141
93MP0005666_abnormal_adipose_tissue1.11874834
94MP0000703_abnormal_thymus_morphology1.11300294
95MP0001533_abnormal_skeleton_physiology1.10998190
96MP0005464_abnormal_platelet_physiology1.10314581
97MP0003279_aneurysm1.10249619
98MP0002084_abnormal_developmental_patter1.10196059
99MP0002108_abnormal_muscle_morphology1.08843091
100MP0002998_abnormal_bone_remodeling1.08609691
101MP0010630_abnormal_cardiac_muscle1.07426022
102MP0002148_abnormal_hypersensitivity_rea1.07402115
103MP0002060_abnormal_skin_morphology1.06686200
104MP0002722_abnormal_immune_system1.03888469
105MP0009703_decreased_birth_body1.03263949
106MP0002086_abnormal_extraembryonic_tissu1.02750467
107MP0001697_abnormal_embryo_size1.02697820
108MP0002254_reproductive_system_inflammat1.02381918
109MP0004197_abnormal_fetal_growth/weight/1.01975997
110MP0003111_abnormal_nucleus_morphology1.01054994
111MP0010094_abnormal_chromosome_stability1.00782396
112MP0008961_abnormal_basal_metabolism1.00403660
113MP0006054_spinal_hemorrhage1.00136876
114MP0004087_abnormal_muscle_fiber0.98489654
115MP0003755_abnormal_palate_morphology0.98173853
116MP0001879_abnormal_lymphatic_vessel0.98075582
117MP0005409_darkened_coat_color0.96965163
118MP0000266_abnormal_heart_morphology0.96460294
119MP0001845_abnormal_inflammatory_respons0.96266020
120MP0000689_abnormal_spleen_morphology0.96107475
121MP0008007_abnormal_cellular_replicative0.94863399
122MP0008932_abnormal_embryonic_tissue0.94166646
123MP0002925_abnormal_cardiovascular_devel0.94040521
124MP0001915_intracranial_hemorrhage0.93952697
125MP0002796_impaired_skin_barrier0.92666681
126MP0002085_abnormal_embryonic_tissue0.92160904
127MP0000432_abnormal_head_morphology0.90813645
128MP0002088_abnormal_embryonic_growth/wei0.90622402
129MP0009053_abnormal_anal_canal0.90581834
130MP0002429_abnormal_blood_cell0.90498884
131MP0005187_abnormal_penis_morphology0.89729302
132MP0003984_embryonic_growth_retardation0.89420180
133MP0005385_cardiovascular_system_phenoty0.89274869
134MP0001544_abnormal_cardiovascular_syste0.89274869
135MP0003567_abnormal_fetal_cardiomyocyte0.88918773
136MP0003937_abnormal_limbs/digits/tail_de0.88389822
137MP0010368_abnormal_lymphatic_system0.87435092
138MP0001873_stomach_inflammation0.86869553
139MP0000767_abnormal_smooth_muscle0.86639279
140MP0002933_joint_inflammation0.86093547
141MP0000350_abnormal_cell_proliferation0.85297225
142MP0002896_abnormal_bone_mineralization0.83996072
143MP0001849_ear_inflammation0.83797225
144MP0000371_diluted_coat_color0.83591232
145MP0002080_prenatal_lethality0.83148559
146MP0001348_abnormal_lacrimal_gland0.82213414
147MP0003724_increased_susceptibility_to0.81941802
148MP0005375_adipose_tissue_phenotype0.81037447
149MP0001661_extended_life_span0.80981881
150MP0008057_abnormal_DNA_replication0.80452404
151MP0003656_abnormal_erythrocyte_physiolo0.78729907
152MP0004084_abnormal_cardiac_muscle0.77990843
153MP0003693_abnormal_embryo_hatching0.77924685
154MP0000537_abnormal_urethra_morphology0.77599426
155MP0001851_eye_inflammation0.77131952
156MP0000490_abnormal_crypts_of0.74082767
157MP0005380_embryogenesis_phenotype0.73785389
158MP0001672_abnormal_embryogenesis/_devel0.73785389
159MP0000627_abnormal_mammary_gland0.73729754
160MP0002128_abnormal_blood_circulation0.72738770
161MP0004272_abnormal_basement_membrane0.72580642

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)4.02929755
2EMG: myopathic abnormalities (HP:0003458)3.57450950
3Muscle hypertrophy of the lower extremities (HP:0008968)3.43594427
4Calf muscle hypertrophy (HP:0008981)3.32210294
5Hematochezia (HP:0002573)3.28976904
6Abnormality of the calf musculature (HP:0001430)3.18891071
7Muscle fiber splitting (HP:0003555)3.16204722
8Neck muscle weakness (HP:0000467)3.03386406
9Centrally nucleated skeletal muscle fibers (HP:0003687)3.01866556
10Distal arthrogryposis (HP:0005684)2.97639376
11Increased density of long bones (HP:0006392)2.95059497
12Rimmed vacuoles (HP:0003805)2.94394857
13Abnormality of skeletal muscle fiber size (HP:0012084)2.91828152
14Distal lower limb muscle weakness (HP:0009053)2.90361753
15Cerebral aneurysm (HP:0004944)2.71037937
16Eczematoid dermatitis (HP:0000976)2.69241794
17Insidious onset (HP:0003587)2.67854411
18Termporal pattern (HP:0011008)2.67854411
19Spinal rigidity (HP:0003306)2.61154794
20Subacute progressive viral hepatitis (HP:0006572)2.58676215
21Calcaneovalgus deformity (HP:0001848)2.54207383
22Autoimmune thrombocytopenia (HP:0001973)2.52876580
23Osteolytic defects of the hand bones (HP:0009699)2.52398746
24Osteolytic defects of the phalanges of the hand (HP:0009771)2.52398746
25Short 4th metacarpal (HP:0010044)2.51394460
26Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.51394460
27Arterial tortuosity (HP:0005116)2.50889911
28Macroorchidism (HP:0000053)2.50801150
29Papillary thyroid carcinoma (HP:0002895)2.49946053
30Areflexia of lower limbs (HP:0002522)2.48769722
31Aortic aneurysm (HP:0004942)2.45422520
32Increased variability in muscle fiber diameter (HP:0003557)2.44463669
33Abnormality of T cell number (HP:0011839)2.44282980
34Abnormality of the hip-girdle musculature (HP:0001445)2.42861404
35Abnormality of the musculature of the pelvis (HP:0001469)2.42861404
36T lymphocytopenia (HP:0005403)2.42139559
37Rectal prolapse (HP:0002035)2.40518673
38Abnormality of the fingertips (HP:0001211)2.39817948
39Curly hair (HP:0002212)2.37224366
40Sudden death (HP:0001699)2.36837180
41Right ventricular cardiomyopathy (HP:0011663)2.36227586
42Frequent falls (HP:0002359)2.33150815
43Vascular tortuosity (HP:0004948)2.32653140
44Arterial thrombosis (HP:0004420)2.31888155
45Exercise-induced muscle cramps (HP:0003710)2.31798759
46Overgrowth (HP:0001548)2.31322384
47Mitral valve prolapse (HP:0001634)2.30417052
48Recurrent viral infections (HP:0004429)2.29966332
49Mildly elevated creatine phosphokinase (HP:0008180)2.27668757
50Myositis (HP:0100614)2.27123984
51Myopathic facies (HP:0002058)2.26329177
52Limb-girdle muscle atrophy (HP:0003797)2.25356551
53Round ear (HP:0100830)2.25297549
54Myocardial infarction (HP:0001658)2.23625508
55Orchitis (HP:0100796)2.23082974
56Absent frontal sinuses (HP:0002688)2.22770485
57Cystic hygroma (HP:0000476)2.22505273
58Recurrent fungal infections (HP:0002841)2.22245214
59Increased connective tissue (HP:0009025)2.20563850
60Retrobulbar optic neuritis (HP:0100654)2.17963021
61Optic neuritis (HP:0100653)2.17963021
62Bundle branch block (HP:0011710)2.17468353
63Dilatation of the ascending aorta (HP:0005111)2.15134537
64Deformed tarsal bones (HP:0008119)2.14526472
65Shoulder girdle muscle weakness (HP:0003547)2.13970355
66Hyporeflexia of lower limbs (HP:0002600)2.09432113
67Muscle fiber inclusion bodies (HP:0100299)2.09112499
68Shallow orbits (HP:0000586)2.08003148
69Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07488803
70Limb-girdle muscle weakness (HP:0003325)2.07272661
71Spinal cord lesions (HP:0100561)2.07027353
72Syringomyelia (HP:0003396)2.07027353
73Slender build (HP:0001533)2.03666916
74Protrusio acetabuli (HP:0003179)2.01039362
75Abnormality of the calcaneus (HP:0008364)1.99552653
76Long clavicles (HP:0000890)1.99298601
77Lipoatrophy (HP:0100578)1.98324940
78Acute myeloid leukemia (HP:0004808)1.97842143
79Persistence of primary teeth (HP:0006335)1.96899359
80Ulnar deviation of the wrist (HP:0003049)1.96856684
81Periodontitis (HP:0000704)1.95583695
82Ventricular tachycardia (HP:0004756)1.95546849
83Disinhibition (HP:0000734)1.95039223
84Volvulus (HP:0002580)1.94028136
85EMG: neuropathic changes (HP:0003445)1.93544204
86Difficulty running (HP:0009046)1.93385655
87Dysmetric saccades (HP:0000641)1.92881186
88Stomatitis (HP:0010280)1.92789346
89Myoglobinuria (HP:0002913)1.89012028
90Aneurysm (HP:0002617)1.88226192
91Bicuspid aortic valve (HP:0001647)1.87684347
92Recurrent abscess formation (HP:0002722)1.87635227
93Abnormality of the nasal septum (HP:0000419)1.87485141
94Rhabdomyosarcoma (HP:0002859)1.87154635
95Vertebral arch anomaly (HP:0008438)1.86211972
96Rhabdomyolysis (HP:0003201)1.83803377
97Narrow palate (HP:0000189)1.82800088
98Nemaline bodies (HP:0003798)1.82339307
99Proximal amyotrophy (HP:0007126)1.82333906
100Genu recurvatum (HP:0002816)1.82013296
101Mediastinal lymphadenopathy (HP:0100721)1.81837389
102Difficulty climbing stairs (HP:0003551)1.80148753
103Abnormality of the 4th metacarpal (HP:0010012)1.79945876
104Type 1 muscle fiber predominance (HP:0003803)1.79433486
105Neoplasm of the small intestine (HP:0100833)1.78470213
106Distal lower limb amyotrophy (HP:0008944)1.78420636
107Hyperacusis (HP:0010780)1.78364819
108Muscular dystrophy (HP:0003560)1.78259608
109Urethral obstruction (HP:0000796)1.77919678
110Aortic dissection (HP:0002647)1.76961075
111Esophageal varix (HP:0002040)1.76580311
112Peritonitis (HP:0002586)1.76126154
113Abnormality of the shoulder girdle musculature (HP:0001435)1.75875367
114Asymmetric septal hypertrophy (HP:0001670)1.75869730
115Premature rupture of membranes (HP:0001788)1.75309880
116Biliary tract neoplasm (HP:0100574)1.75195936
117Ankyloglossia (HP:0010296)1.75055696
118Subaortic stenosis (HP:0001682)1.74952448
119Abnormality of the left ventricular outflow tract (HP:0011103)1.74952448
120Viral hepatitis (HP:0006562)1.74098395
121Facial diplegia (HP:0001349)1.72792943
122Enlarged penis (HP:0000040)1.71139591
123Spontaneous hematomas (HP:0007420)1.70587020
124Absent phalangeal crease (HP:0006109)1.70512732
125Heterotopia (HP:0002282)1.70399706
126Abnormal platelet volume (HP:0011876)1.69316754
127Chest pain (HP:0100749)1.68075676
128Malignant gastrointestinal tract tumors (HP:0006749)1.67382293
129Gastrointestinal carcinoma (HP:0002672)1.67382293
130Nephroblastoma (Wilms tumor) (HP:0002667)1.66526251
131Embryonal renal neoplasm (HP:0011794)1.66476412
132Malignant hyperthermia (HP:0002047)1.66370084
133Long eyelashes (HP:0000527)1.66368762
134Progressive external ophthalmoplegia (HP:0000590)1.66074835
135Interstitial pulmonary disease (HP:0006530)1.65881545
136Transitional cell carcinoma of the bladder (HP:0006740)1.65873663
137Increased mean platelet volume (HP:0011877)1.65413098
138Abnormal finger flexion creases (HP:0006143)1.64846369
139Large earlobe (HP:0009748)1.64071181
140Cutis marmorata (HP:0000965)1.63884708
141Abnormality of the peritoneum (HP:0002585)1.62640219
142Dislocated radial head (HP:0003083)1.62638157
143Hip contracture (HP:0003273)1.62220632
144Recurrent bacterial skin infections (HP:0005406)1.61974441
145Cellulitis (HP:0100658)1.61223921
146Dilated cardiomyopathy (HP:0001644)1.61194732
147Hypoplastic ischia (HP:0003175)1.61026401
148Hyperkalemia (HP:0002153)1.60156342
149Abnormality of the foot musculature (HP:0001436)1.58986125
150Cortical dysplasia (HP:0002539)1.58762794
151Radial bowing (HP:0002986)1.57979518
152Gastrointestinal infarctions (HP:0005244)1.57225995
153Neoplasm of the rectum (HP:0100743)1.57183516
154Popliteal pterygium (HP:0009756)1.57103690
155Cervical subluxation (HP:0003308)1.57093918
156Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.57059612
157Abnormality of the pericardium (HP:0001697)1.56920014
158Nasal polyposis (HP:0100582)1.56283620
159Deep philtrum (HP:0002002)1.55837224
160Bladder carcinoma (HP:0002862)1.55681404
161Bladder neoplasm (HP:0009725)1.55681404
162Lower limb amyotrophy (HP:0007210)1.55050610
163Recurrent gram-negative bacterial infections (HP:0005420)1.55023376
164Cutaneous melanoma (HP:0012056)1.53933225
165Pelvic girdle muscle weakness (HP:0003749)1.53785077
166Vasculitis (HP:0002633)1.53458492
167Trigonocephaly (HP:0000243)1.53084328
168Scapular winging (HP:0003691)1.52391594
169Prominent nose (HP:0000448)1.50569853
170Limited elbow extension (HP:0001377)1.50559705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.62971854
2CDK123.09721056
3TTN3.03656787
4TSSK62.93355003
5LATS22.71077608
6TRIB32.68496560
7PKN22.57436480
8LATS12.44638011
9MAP3K102.44057040
10MKNK22.43391015
11NEK12.39701153
12NEK92.33436747
13RIPK12.29936534
14EIF2AK32.23601781
15MAP3K142.19723753
16FGFR32.02435220
17STK101.96858942
18CDK61.92310048
19STK38L1.89373418
20JAK31.88647692
21PHKG21.87866869
22PHKG11.87866869
23TYK21.85299393
24JAK11.79304722
25FRK1.78439544
26KSR11.75669280
27PTK61.73110558
28BRSK21.71082079
29MAP3K91.70586867
30STK31.67746881
31PNCK1.65730719
32TNIK1.59916307
33MAP4K11.57195205
34RPS6KA41.56430284
35MKNK11.56155242
36CAMK1D1.55710250
37FGFR41.44886644
38DMPK1.43612310
39LRRK21.41306074
40CAMK1G1.40805213
41WEE11.39286758
42TTK1.38504737
43ALK1.36830364
44MST41.36394527
45MOS1.35439653
46TBK11.34852918
47TXK1.32942629
48ERBB41.30415880
49EEF2K1.29791253
50CHUK1.26866445
51AKT31.26775039
52TRIM281.23225172
53MAP2K31.20229728
54ITK1.18995899
55SCYL21.18879040
56SIK11.17390164
57PBK1.17060737
58EPHA31.15707968
59TGFBR21.14100976
60EIF2AK11.13093747
61MST1R1.10677748
62PDGFRB1.09963742
63CSK1.08874126
64PDGFRA1.07271732
65BCR1.05764011
66ZAP701.03119088
67BMX1.02670947
68IKBKB0.99922548
69HCK0.97026045
70ACVR1B0.96758618
71PDK30.95282129
72PDK40.95282129
73BRD40.95007145
74PIK3CG0.94080365
75TAF10.93927063
76FGFR10.93795376
77MAP3K70.93785867
78PLK30.93663138
79CDK40.92026415
80MARK30.91299802
81JAK20.90556224
82PIM10.90323001
83MTOR0.88704405
84MET0.88190756
85BUB10.86822970
86IKBKE0.86103740
87SGK20.85017891
88EIF2AK20.83710649
89KSR20.81874656
90IRAK30.81653686
91EPHB10.81290323
92EPHA20.80818006
93ERN10.78774127
94RET0.76769350
95NLK0.76667477
96SRPK10.75702222
97MAP3K130.74612401
98PAK40.74053524
99MELK0.71310572
100STK240.70811309
101FGFR20.70725523
102SGK30.68963759
103NEK20.68830327
104EGFR0.68400213
105STK40.68243317
106MAP3K60.67842759
107TRPM70.67659902
108CDK90.66712222
109ERBB30.66165114
110FLT30.66022832
111YES10.65133620
112CSF1R0.64986727
113MAP3K50.63494687
114LCK0.60959772
115PLK20.59168646
116BTK0.58720325
117NUAK10.58578962
118MAP3K80.58486858
119SIK20.56680834
120RIPK40.56373389
121TEC0.54572631
122MAP3K30.52400186
123ROCK20.51565066
124PRKAA20.50415594
125PTK20.50145669
126INSR0.48850172
127TGFBR10.48193498
128MYLK0.47719741
129PDK10.47131102
130CDC70.46372887
131NTRK10.45968766
132PAK20.45500617
133RAF10.44736857
134MAP3K20.44230994
135DDR20.42318081
136PLK10.40820819
137CASK0.39868807
138SIK30.39701417
139WNK10.39635304
140MARK10.39625233
141KIT0.39455261
142PRKCH0.39359204
143ROCK10.39022436
144CDK80.38527132
145PDK20.38462127
146PIK3CA0.36571051
147IGF1R0.36394923
148SYK0.36071154
149DYRK1B0.34729457
150GSK3A0.33454678
151FER0.33195749
152RPS6KB10.33151821
153MAP2K10.32205189
154MAPK100.32098614
155TIE10.32083201
156MAP3K120.30025580
157BRAF0.29936249

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.11768584
2Osteoclast differentiation_Homo sapiens_hsa043801.91588070
3NF-kappa B signaling pathway_Homo sapiens_hsa040641.81975251
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.73526190
5Chronic myeloid leukemia_Homo sapiens_hsa052201.72783808
6Circadian rhythm_Homo sapiens_hsa047101.68923620
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68764682
8Viral myocarditis_Homo sapiens_hsa054161.68276873
9B cell receptor signaling pathway_Homo sapiens_hsa046621.68153615
10Measles_Homo sapiens_hsa051621.65967423
11Toxoplasmosis_Homo sapiens_hsa051451.65412556
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65030370
13TNF signaling pathway_Homo sapiens_hsa046681.57110490
14Cell cycle_Homo sapiens_hsa041101.54086697
15Adherens junction_Homo sapiens_hsa045201.54003359
16Small cell lung cancer_Homo sapiens_hsa052221.53600056
17T cell receptor signaling pathway_Homo sapiens_hsa046601.53073667
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52774309
19Tight junction_Homo sapiens_hsa045301.52584535
20Antigen processing and presentation_Homo sapiens_hsa046121.45262735
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43009974
22Legionellosis_Homo sapiens_hsa051341.42502131
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.41166521
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.38946842
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37273002
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36842749
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36080590
28Graft-versus-host disease_Homo sapiens_hsa053321.35023128
29Proteoglycans in cancer_Homo sapiens_hsa052051.34840394
30Non-homologous end-joining_Homo sapiens_hsa034501.32471002
31Acute myeloid leukemia_Homo sapiens_hsa052211.30474255
32Hepatitis B_Homo sapiens_hsa051611.30321736
33mTOR signaling pathway_Homo sapiens_hsa041501.29333433
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.27633759
35RNA transport_Homo sapiens_hsa030131.25786943
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25546859
37MicroRNAs in cancer_Homo sapiens_hsa052061.25438420
38Focal adhesion_Homo sapiens_hsa045101.24293486
39Pancreatic cancer_Homo sapiens_hsa052121.23890573
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22439085
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22194252
42Influenza A_Homo sapiens_hsa051641.21000176
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18556207
44Shigellosis_Homo sapiens_hsa051311.17389572
45Allograft rejection_Homo sapiens_hsa053301.17351976
46Primary immunodeficiency_Homo sapiens_hsa053401.17268862
47Tuberculosis_Homo sapiens_hsa051521.16207290
48Insulin resistance_Homo sapiens_hsa049311.15647390
49ErbB signaling pathway_Homo sapiens_hsa040121.13010006
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12409874
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.12299840
52Herpes simplex infection_Homo sapiens_hsa051681.11659350
53Platelet activation_Homo sapiens_hsa046111.11523383
54Viral carcinogenesis_Homo sapiens_hsa052031.11501350
55Pertussis_Homo sapiens_hsa051331.10486334
56Apoptosis_Homo sapiens_hsa042101.10470425
57mRNA surveillance pathway_Homo sapiens_hsa030151.10330610
58Amoebiasis_Homo sapiens_hsa051461.10086726
59Malaria_Homo sapiens_hsa051441.06791617
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.06541294
61Colorectal cancer_Homo sapiens_hsa052101.05940645
62Salmonella infection_Homo sapiens_hsa051321.05121922
63HTLV-I infection_Homo sapiens_hsa051661.04977283
64Vitamin B6 metabolism_Homo sapiens_hsa007501.03477311
65Hematopoietic cell lineage_Homo sapiens_hsa046401.03448755
66Dorso-ventral axis formation_Homo sapiens_hsa043201.03122072
67Prolactin signaling pathway_Homo sapiens_hsa049171.00411787
68Endometrial cancer_Homo sapiens_hsa052131.00371394
69Chemokine signaling pathway_Homo sapiens_hsa040620.99887814
70VEGF signaling pathway_Homo sapiens_hsa043700.99587403
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.98457128
72Non-small cell lung cancer_Homo sapiens_hsa052230.97556986
73Melanoma_Homo sapiens_hsa052180.96720562
74FoxO signaling pathway_Homo sapiens_hsa040680.95567743
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.94835783
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94492940
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93798087
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.92507248
79Renal cell carcinoma_Homo sapiens_hsa052110.92489267
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92029118
81Prostate cancer_Homo sapiens_hsa052150.92002729
82Staphylococcus aureus infection_Homo sapiens_hsa051500.91396010
83Wnt signaling pathway_Homo sapiens_hsa043100.91275558
84HIF-1 signaling pathway_Homo sapiens_hsa040660.90968702
85Glioma_Homo sapiens_hsa052140.90545228
86Type II diabetes mellitus_Homo sapiens_hsa049300.89234393
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.88535983
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87337468
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87334129
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85605283
91Long-term potentiation_Homo sapiens_hsa047200.84927593
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82369778
93Hepatitis C_Homo sapiens_hsa051600.81595563
94Estrogen signaling pathway_Homo sapiens_hsa049150.79363174
95ECM-receptor interaction_Homo sapiens_hsa045120.79247215
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77947650
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77398160
98Oocyte meiosis_Homo sapiens_hsa041140.76207347
99Type I diabetes mellitus_Homo sapiens_hsa049400.75929163
100Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75583672
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72001503
102Oxytocin signaling pathway_Homo sapiens_hsa049210.71794457
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71689691
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71461398
105Lysine degradation_Homo sapiens_hsa003100.70788924
106TGF-beta signaling pathway_Homo sapiens_hsa043500.70324059
107p53 signaling pathway_Homo sapiens_hsa041150.69145396
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69064332
109Melanogenesis_Homo sapiens_hsa049160.69019192
110Inositol phosphate metabolism_Homo sapiens_hsa005620.68195259
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67896275
112PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67527781
113Insulin signaling pathway_Homo sapiens_hsa049100.67110898
114Hedgehog signaling pathway_Homo sapiens_hsa043400.65718408
115Dilated cardiomyopathy_Homo sapiens_hsa054140.65641328
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65219984
117Thyroid cancer_Homo sapiens_hsa052160.64192566
118Basal cell carcinoma_Homo sapiens_hsa052170.63708134
119GnRH signaling pathway_Homo sapiens_hsa049120.61818592
120Epstein-Barr virus infection_Homo sapiens_hsa051690.61638321
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61034586
122Axon guidance_Homo sapiens_hsa043600.60452527
123AMPK signaling pathway_Homo sapiens_hsa041520.60133385
124MAPK signaling pathway_Homo sapiens_hsa040100.59619864
125Pathways in cancer_Homo sapiens_hsa052000.59437078
126Gap junction_Homo sapiens_hsa045400.58746653
127Propanoate metabolism_Homo sapiens_hsa006400.57302757
128Carbon metabolism_Homo sapiens_hsa012000.56305458
129Cysteine and methionine metabolism_Homo sapiens_hsa002700.56225884
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56205625
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55758157
132Bladder cancer_Homo sapiens_hsa052190.55630763
133Basal transcription factors_Homo sapiens_hsa030220.55584401
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55491994
135Nitrogen metabolism_Homo sapiens_hsa009100.55176225
136Systemic lupus erythematosus_Homo sapiens_hsa053220.54986043
137Hippo signaling pathway_Homo sapiens_hsa043900.54173917
138Pyruvate metabolism_Homo sapiens_hsa006200.54121558
139Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53109830
140Glucagon signaling pathway_Homo sapiens_hsa049220.51185146
141Long-term depression_Homo sapiens_hsa047300.49545190

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