ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.13475720
2	serotonin metabolic process (GO:0042428)	5.05396229
3	response to pheromone (GO:0019236)	4.73520958
4	primary amino compound metabolic process (GO:1901160)	4.65424479
5	gamma-aminobutyric acid transport (GO:0015812)	4.35155506
6	negative regulation of translation, ncRNA-mediated (GO:0040033)	4.22505446
7	regulation of translation, ncRNA-mediated (GO:0045974)	4.22505446
8	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	4.22505446
9	neuronal action potential (GO:0019228)	4.19534785
10	kynurenine metabolic process (GO:0070189)	4.04686879
11	tryptophan catabolic process (GO:0006569)	3.95366820
12	indole-containing compound catabolic process (GO:0042436)	3.95366820
13	indolalkylamine catabolic process (GO:0046218)	3.95366820
14	indole-containing compound metabolic process (GO:0042430)	3.89256082
15	interkinetic nuclear migration (GO:0022027)	3.83164451
16	negative regulation of sodium ion transport (GO:0010766)	3.67960378
17	regulation of posttranscriptional gene silencing (GO:0060147)	3.66080102
18	regulation of gene silencing by miRNA (GO:0060964)	3.66080102
19	regulation of gene silencing by RNA (GO:0060966)	3.66080102
20	cilium or flagellum-dependent cell motility (GO:0001539)	3.65009523
21	regulation of pigment cell differentiation (GO:0050932)	3.60825680
22	indolalkylamine metabolic process (GO:0006586)	3.50486328
23	neural tube formation (GO:0001841)	3.35456820
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.34799619
25	reflex (GO:0060004)	3.33123841
26	tryptophan metabolic process (GO:0006568)	3.31673430
27	L-fucose metabolic process (GO:0042354)	3.30164944
28	L-fucose catabolic process (GO:0042355)	3.30164944
29	fucose catabolic process (GO:0019317)	3.30164944
30	cytoplasmic mRNA processing body assembly (GO:0033962)	3.29070045
31	endosome to pigment granule transport (GO:0043485)	3.22422810
32	endosome to melanosome transport (GO:0035646)	3.22422810
33	positive regulation of developmental pigmentation (GO:0048087)	3.21840433
34	sulfation (GO:0051923)	3.20238431
35	detection of light stimulus involved in visual perception (GO:0050908)	3.20014701
36	detection of light stimulus involved in sensory perception (GO:0050962)	3.20014701
37	snRNA transcription (GO:0009301)	3.19491187
38	membrane depolarization during action potential (GO:0086010)	3.18972865
39	regulation of hippo signaling (GO:0035330)	3.16778489
40	regulation of establishment of cell polarity (GO:2000114)	3.07313910
41	negative regulation of systemic arterial blood pressure (GO:0003085)	3.04835069
42	behavioral response to ethanol (GO:0048149)	3.01254640
43	spinal cord motor neuron differentiation (GO:0021522)	2.99220719
44	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.97285958
45	urinary tract smooth muscle contraction (GO:0014848)	2.96970543
46	histone-serine phosphorylation (GO:0035404)	2.94879554
47	cellular ketone body metabolic process (GO:0046950)	2.94615789
48	monoubiquitinated protein deubiquitination (GO:0035520)	2.92969786
49	positive regulation of CREB transcription factor activity (GO:0032793)	2.88156397
50	protein K48-linked deubiquitination (GO:0071108)	2.83460315
51	positive regulation of action potential (GO:0045760)	2.81707554
52	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.78899662
53	histone H4-K12 acetylation (GO:0043983)	2.77340756
54	NAD biosynthetic process (GO:0009435)	2.76737849
55	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.75538949
56	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.74248712
57	negative regulation of protein localization to cell surface (GO:2000009)	2.72806620
58	flavonoid metabolic process (GO:0009812)	2.71504021
59	cAMP catabolic process (GO:0006198)	2.71430576
60	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.70635550
61	cardiovascular system development (GO:0072358)	2.70506333
62	hindbrain development (GO:0030902)	2.70167435
63	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.69556509
64	kidney morphogenesis (GO:0060993)	2.69333144
65	cerebellar Purkinje cell differentiation (GO:0021702)	2.68965878
66	neuronal action potential propagation (GO:0019227)	2.68914479
67	action potential (GO:0001508)	2.68293726
68	pericardium development (GO:0060039)	2.68281771
69	peristalsis (GO:0030432)	2.68157393
70	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66832161
71	regulation of action potential (GO:0098900)	2.64020912
72	neuron maturation (GO:0042551)	2.63670976
73	signal peptide processing (GO:0006465)	2.62349674
74	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.61348462
75	startle response (GO:0001964)	2.60356031
76	postsynaptic membrane organization (GO:0001941)	2.59244953
77	ketone body metabolic process (GO:1902224)	2.58836998
78	glutamate receptor signaling pathway (GO:0007215)	2.58147997
79	musculoskeletal movement (GO:0050881)	2.57626745
80	multicellular organismal movement (GO:0050879)	2.57626745
81	protein localization to synapse (GO:0035418)	2.54958482
82	neuron cell-cell adhesion (GO:0007158)	2.53343556
83	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.49748433
84	protein import into peroxisome matrix (GO:0016558)	2.49532768
85	synaptic transmission, glutamatergic (GO:0035249)	2.47915603
86	establishment of protein localization to Golgi (GO:0072600)	2.47617756
87	regulation of mesoderm development (GO:2000380)	2.46147381
88	cilium organization (GO:0044782)	2.45115328
89	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.44449692
90	phospholipid translocation (GO:0045332)	2.42991905
91	lipid translocation (GO:0034204)	2.42991905
92	regulation of sarcomere organization (GO:0060297)	2.42984992
93	cyclic nucleotide catabolic process (GO:0009214)	2.42812296
94	cornea development in camera-type eye (GO:0061303)	2.42405894
95	proline transport (GO:0015824)	2.41593471
96	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.40556063
97	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.40459129
98	limb development (GO:0060173)	2.40213470
99	appendage development (GO:0048736)	2.40213470
100	cilium assembly (GO:0042384)	2.39420840

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.23298380
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.36036142
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21483454
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.08770415
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98445824
6	VDR_22108803_ChIP-Seq_LS180_Human	2.76035905
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.63131258
8	TAF15_26573619_Chip-Seq_HEK293_Human	2.34773756
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34709643
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.33428761
11	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.26139388
12	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.06684046
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.03399459
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.97159177
15	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.96301684
16	EWS_26573619_Chip-Seq_HEK293_Human	1.91368713
17	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91181482
18	P300_19829295_ChIP-Seq_ESCs_Human	1.89779591
19	AR_21572438_ChIP-Seq_LNCaP_Human	1.84192938
20	STAT3_23295773_ChIP-Seq_U87_Human	1.82834109
21	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.81667987
22	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.80761524
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.79376115
24	FUS_26573619_Chip-Seq_HEK293_Human	1.76134213
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.75450924
26	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.70032534
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68199226
28	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66064997
29	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.63304256
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.63304256
31	TP53_16413492_ChIP-PET_HCT116_Human	1.62235041
32	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61314685
33	DROSHA_22980978_ChIP-Seq_HELA_Human	1.60855669
34	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60752291
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.59025872
36	AR_25329375_ChIP-Seq_VCAP_Human	1.58019946
37	TCF4_23295773_ChIP-Seq_U87_Human	1.57591051
38	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.55772976
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54720584
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52918612
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.52089889
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.51195671
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.49363158
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.45043341
45	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.43963706
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.40981293
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38013615
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36970310
49	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.36507045
50	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.35247712
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34198156
52	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.33812170
53	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.33367944
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32031623
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.30065603
56	AHR_22903824_ChIP-Seq_MCF-7_Human	1.29990244
57	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.29874996
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29696164
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.28561258
60	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.26715483
61	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.24896854
62	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.24743095
63	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.24227411
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.23738597
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23574279
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.23574279
67	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.22971379
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.22079247
69	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21904848
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21743431
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20369373
72	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.18167860
73	KDM2B_26808549_Chip-Seq_REH_Human	1.17409057
74	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.17010292
75	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.15585622
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.13899489
77	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13654138
78	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.13276226
79	RXR_22108803_ChIP-Seq_LS180_Human	1.10724443
80	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09987477
81	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.08750136
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07072896
83	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06723917
84	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06692458
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06172725
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.06090626
87	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.05483930
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04498534
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04488146
90	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02584875
91	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.01287009
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.01161229
93	IRF1_19129219_ChIP-ChIP_H3396_Human	1.01072983
94	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.00879786
95	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.00257710
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99757338
97	AR_19668381_ChIP-Seq_PC3_Human	0.98994201
98	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.98643439
99	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.98643439
100	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97674547

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.62615858
2	MP0003195_calcinosis	3.25211063
3	MP0009046_muscle_twitch	3.16210622
4	MP0003646_muscle_fatigue	2.67503325
5	MP0009745_abnormal_behavioral_response	2.49935014
6	MP0001968_abnormal_touch/_nociception	2.49696182
7	MP0003890_abnormal_embryonic-extraembry	2.31078964
8	MP0003136_yellow_coat_color	2.28729463
9	MP0004043_abnormal_pH_regulation	2.22773528
10	MP0005551_abnormal_eye_electrophysiolog	2.17494227
11	MP0002735_abnormal_chemical_nociception	2.11180493
12	MP0001501_abnormal_sleep_pattern	2.07189393
13	MP0000427_abnormal_hair_cycle	2.04600486
14	MP0002064_seizures	2.03684168
15	MP0002272_abnormal_nervous_system	1.99859170
16	MP0004142_abnormal_muscle_tone	1.97395488
17	MP0008057_abnormal_DNA_replication	1.96303059
18	MP0003880_abnormal_central_pattern	1.90118143
19	MP0001986_abnormal_taste_sensitivity	1.89552158
20	MP0008877_abnormal_DNA_methylation	1.89056960
21	MP0002736_abnormal_nociception_after	1.88584787
22	MP0004133_heterotaxia	1.86660584
23	MP0005645_abnormal_hypothalamus_physiol	1.82250461
24	MP0001486_abnormal_startle_reflex	1.81786391
25	MP0003635_abnormal_synaptic_transmissio	1.79887904
26	MP0002102_abnormal_ear_morphology	1.75815455
27	MP0002067_abnormal_sensory_capabilities	1.75806588
28	MP0002572_abnormal_emotion/affect_behav	1.74586840
29	MP0002063_abnormal_learning/memory/cond	1.66124450
30	MP0003787_abnormal_imprinting	1.65485926
31	MP0005187_abnormal_penis_morphology	1.64835974
32	MP0004924_abnormal_behavior	1.63348006
33	MP0005386_behavior/neurological_phenoty	1.63348006
34	MP0008872_abnormal_physiological_respon	1.63099869
35	MP0004130_abnormal_muscle_cell	1.58057730
36	MP0000778_abnormal_nervous_system	1.55545024
37	MP0004885_abnormal_endolymph	1.54307999
38	MP0002734_abnormal_mechanical_nocicepti	1.53966967
39	MP0000383_abnormal_hair_follicle	1.52319058
40	MP0002733_abnormal_thermal_nociception	1.49097166
41	MP0004145_abnormal_muscle_electrophysio	1.47943645
42	MP0005174_abnormal_tail_pigmentation	1.46272093
43	MP0004742_abnormal_vestibular_system	1.44723837
44	MP0001970_abnormal_pain_threshold	1.43328237
45	MP0000631_abnormal_neuroendocrine_gland	1.42554903
46	MP0002557_abnormal_social/conspecific_i	1.41892956
47	MP0008961_abnormal_basal_metabolism	1.40406433
48	MP0001485_abnormal_pinna_reflex	1.39239875
49	MP0003119_abnormal_digestive_system	1.38308436
50	MP0002638_abnormal_pupillary_reflex	1.37513932
51	MP0005646_abnormal_pituitary_gland	1.36202208
52	MP0010386_abnormal_urinary_bladder	1.30992475
53	MP0006276_abnormal_autonomic_nervous	1.29748928
54	MP0005253_abnormal_eye_physiology	1.27528532
55	MP0002928_abnormal_bile_duct	1.27046672
56	MP0002837_dystrophic_cardiac_calcinosis	1.23648582
57	MP0001440_abnormal_grooming_behavior	1.19826993
58	MP0002938_white_spotting	1.14688707
59	MP0004147_increased_porphyrin_level	1.11660265
60	MP0002876_abnormal_thyroid_physiology	1.11538020
61	MP0005423_abnormal_somatic_nervous	1.09560625
62	MP0002184_abnormal_innervation	1.06744315
63	MP0000955_abnormal_spinal_cord	1.05221991
64	MP0003283_abnormal_digestive_organ	1.02579649
65	MP0002882_abnormal_neuron_morphology	1.01713483
66	MP0006292_abnormal_olfactory_placode	1.01582026
67	MP0005448_abnormal_energy_balance	0.98146619
68	MP0006072_abnormal_retinal_apoptosis	0.97497817
69	MP0005195_abnormal_posterior_eye	0.95211646
70	MP0004215_abnormal_myocardial_fiber	0.93175018
71	MP0003937_abnormal_limbs/digits/tail_de	0.91825558
72	MP0004270_analgesia	0.91473463
73	MP0002752_abnormal_somatic_nervous	0.91404896
74	MP0001324_abnormal_eye_pigmentation	0.91355215
75	MP0000230_abnormal_systemic_arterial	0.90721625
76	MP0003632_abnormal_nervous_system	0.90648069
77	MP0002653_abnormal_ependyma_morphology	0.89371769
78	MP0000026_abnormal_inner_ear	0.87802851
79	MP0002160_abnormal_reproductive_system	0.87316724
80	MP0003633_abnormal_nervous_system	0.85559582
81	MP0000538_abnormal_urinary_bladder	0.84432562
82	MP0002152_abnormal_brain_morphology	0.81546171
83	MP0003631_nervous_system_phenotype	0.81150938
84	MP0000647_abnormal_sebaceous_gland	0.80118451
85	MP0005389_reproductive_system_phenotype	0.79784705
86	MP0002229_neurodegeneration	0.79042464
87	MP0001984_abnormal_olfaction	0.78677770
88	MP0003137_abnormal_impulse_conducting	0.78626044
89	MP0005171_absent_coat_pigmentation	0.78002463
90	MP0005266_abnormal_metabolism	0.77392955
91	MP0002066_abnormal_motor_capabilities/c	0.76966656
92	MP0002751_abnormal_autonomic_nervous	0.76482656
93	MP0001502_abnormal_circadian_rhythm	0.75903674
94	MP0001664_abnormal_digestion	0.75768267
95	MP0008875_abnormal_xenobiotic_pharmacok	0.74856316
96	MP0000470_abnormal_stomach_morphology	0.73337149
97	MP0003698_abnormal_male_reproductive	0.72602984
98	MP0003959_abnormal_lean_body	0.71895034
99	MP0002234_abnormal_pharynx_morphology	0.70602892
100	MP0001963_abnormal_hearing_physiology	0.70176023

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	5.34460469
2	Genetic anticipation (HP:0003743)	5.13524143
3	Pancreatic cysts (HP:0001737)	4.31989046
4	Protruding tongue (HP:0010808)	4.31650864
5	Progressive cerebellar ataxia (HP:0002073)	4.15611589
6	Birth length less than 3rd percentile (HP:0003561)	4.00710545
7	Pancreatic fibrosis (HP:0100732)	3.90715728
8	True hermaphroditism (HP:0010459)	3.72859712
9	Molar tooth sign on MRI (HP:0002419)	3.68453646
10	Abnormality of midbrain morphology (HP:0002418)	3.68453646
11	Gaze-evoked nystagmus (HP:0000640)	3.67869748
12	Clumsiness (HP:0002312)	3.59650503
13	Congenital stationary night blindness (HP:0007642)	3.53225345
14	Abnormality of alanine metabolism (HP:0010916)	3.44279037
15	Hyperalaninemia (HP:0003348)	3.44279037
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.44279037
17	Nephronophthisis (HP:0000090)	3.38487801
18	Inability to walk (HP:0002540)	3.21909702
19	Fair hair (HP:0002286)	3.11458719
20	Broad-based gait (HP:0002136)	3.08812186
21	Abnormality of the renal medulla (HP:0100957)	3.04933112
22	Patellar aplasia (HP:0006443)	3.04380528
23	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.00277188
24	Febrile seizures (HP:0002373)	2.93056756
25	Cystic liver disease (HP:0006706)	2.88788944
26	Tubular atrophy (HP:0000092)	2.82302141
27	Large for gestational age (HP:0001520)	2.77411958
28	Abnormality of the renal cortex (HP:0011035)	2.77256743
29	Aplasia/Hypoplasia of the patella (HP:0006498)	2.76577751
30	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.73643921
31	Progressive inability to walk (HP:0002505)	2.73619371
32	Type II lissencephaly (HP:0007260)	2.67238273
33	Drooling (HP:0002307)	2.66532939
34	Furrowed tongue (HP:0000221)	2.65645321
35	Chronic hepatic failure (HP:0100626)	2.64946986
36	Attenuation of retinal blood vessels (HP:0007843)	2.59560164
37	Absent speech (HP:0001344)	2.53869788
38	Medial flaring of the eyebrow (HP:0010747)	2.51630336
39	Generalized hypopigmentation of hair (HP:0011358)	2.50268954
40	Excessive salivation (HP:0003781)	2.43557436
41	Focal motor seizures (HP:0011153)	2.37003540
42	Hypoplastic ischia (HP:0003175)	2.32281610
43	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.30458200
44	Chorioretinal atrophy (HP:0000533)	2.24369496
45	Gait imbalance (HP:0002141)	2.23814726
46	Focal seizures (HP:0007359)	2.23787819
47	Widely spaced teeth (HP:0000687)	2.22824203
48	Dialeptic seizures (HP:0011146)	2.21778905
49	Breast hypoplasia (HP:0003187)	2.20735282
50	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.20150430
51	Absent/shortened dynein arms (HP:0200106)	2.20150430
52	Abnormality of the ischium (HP:0003174)	2.19610592
53	Lissencephaly (HP:0001339)	2.19062829
54	Abnormality of secondary sexual hair (HP:0009888)	2.16976286
55	Abnormality of the axillary hair (HP:0100134)	2.16976286
56	Partial agenesis of the corpus callosum (HP:0001338)	2.12555537
57	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.11466847
58	Polydipsia (HP:0001959)	2.10384317
59	Abnormal drinking behavior (HP:0030082)	2.10384317
60	Hemiparesis (HP:0001269)	2.09459229
61	Sclerocornea (HP:0000647)	2.09102436
62	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.08187199
63	Cerebellar dysplasia (HP:0007033)	2.07848913
64	Absence seizures (HP:0002121)	2.06394261
65	Congenital primary aphakia (HP:0007707)	2.05297249
66	Congenital hepatic fibrosis (HP:0002612)	2.04670694
67	Decreased circulating renin level (HP:0003351)	2.01978938
68	Hypoplastic labia majora (HP:0000059)	2.01068254
69	Anencephaly (HP:0002323)	1.97959446
70	Genital tract atresia (HP:0001827)	1.97493582
71	Preaxial foot polydactyly (HP:0001841)	1.97355882
72	Abnormality of binocular vision (HP:0011514)	1.97006547
73	Diplopia (HP:0000651)	1.97006547
74	Abnormal respiratory epithelium morphology (HP:0012253)	1.96856082
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.96856082
76	Congenital, generalized hypertrichosis (HP:0004540)	1.93904070
77	Atonic seizures (HP:0010819)	1.93060864
78	Vaginal atresia (HP:0000148)	1.93013027
79	Concave nail (HP:0001598)	1.92966062
80	Epileptic encephalopathy (HP:0200134)	1.91159694
81	Dysmetric saccades (HP:0000641)	1.90622487
82	Stomach cancer (HP:0012126)	1.90274979
83	Urinary bladder sphincter dysfunction (HP:0002839)	1.89879858
84	Pheochromocytoma (HP:0002666)	1.89811460
85	Poor coordination (HP:0002370)	1.89798130
86	Keratoconus (HP:0000563)	1.89674890
87	Increased corneal curvature (HP:0100692)	1.89674890
88	Male pseudohermaphroditism (HP:0000037)	1.87955442
89	Abnormality of the labia majora (HP:0012881)	1.86040082
90	Blue irides (HP:0000635)	1.82684574
91	Decreased central vision (HP:0007663)	1.81319654
92	Abolished electroretinogram (ERG) (HP:0000550)	1.81227488
93	Congenital sensorineural hearing impairment (HP:0008527)	1.80869214
94	Macroglossia (HP:0000158)	1.80517531
95	Nephrogenic diabetes insipidus (HP:0009806)	1.80392594
96	Impaired smooth pursuit (HP:0007772)	1.77856463
97	Inappropriate behavior (HP:0000719)	1.76645018
98	Abnormality of the pubic bones (HP:0003172)	1.75970269
99	Small hand (HP:0200055)	1.74208231
100	Prominent supraorbital ridges (HP:0000336)	1.73218423

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.58005773
2	ACVR1B	4.79679071
3	BMPR1B	3.86353475
4	CASK	3.17615197
5	ADRBK2	2.80040360
6	INSRR	2.33286562
7	PNCK	2.32974409
8	TLK1	1.90304295
9	MKNK2	1.89440161
10	TGFBR1	1.83143473
11	GRK1	1.81833684
12	ZAK	1.76804906
13	MARK1	1.76197758
14	WNK3	1.70068548
15	DAPK2	1.67585825
16	NTRK3	1.67158923
17	MAP3K4	1.66459877
18	MAPK13	1.60933559
19	SIK2	1.58042690
20	AKT3	1.45165679
21	CAMKK2	1.43598533
22	ADRBK1	1.43382679
23	WNK4	1.38904840
24	CAMK1G	1.25347732
25	TNIK	1.22888062
26	NTRK2	1.13426388
27	TAOK3	1.10184911
28	SGK2	1.08129934
29	OXSR1	1.07180826
30	CAMK1D	1.04853581
31	PIK3CA	1.03060460
32	PINK1	1.03057052
33	PTK2B	0.96911159
34	MAP2K7	0.93240915
35	MAPK15	0.92217120
36	NEK2	0.89416129
37	PRKCG	0.84510563
38	PAK3	0.83505193
39	MELK	0.79468686
40	NUAK1	0.78098392
41	WNK1	0.76419037
42	SGK494	0.75786816
43	SGK223	0.75786816
44	STK38L	0.72278020
45	PRKCE	0.72107715
46	MKNK1	0.69586375
47	TRPM7	0.68844167
48	MAP2K1	0.66861759
49	CAMK2A	0.65565325
50	IRAK1	0.64773274
51	CHUK	0.64452158
52	BRSK2	0.62295022
53	STK11	0.60715220
54	STK39	0.60555076
55	MAP3K7	0.59761956
56	CAMKK1	0.59338567
57	MAP2K4	0.58137149
58	PKN1	0.57443592
59	MAP4K2	0.56991095
60	TYRO3	0.56678084
61	TEC	0.55715872
62	CAMK1	0.54764091
63	RPS6KA6	0.54002737
64	CAMK4	0.49519852
65	LATS1	0.47842103
66	OBSCN	0.47701405
67	PRKAA2	0.47277164
68	ERBB2	0.47208334
69	STK38	0.46791385
70	PRKAA1	0.45650840
71	RPS6KA5	0.45209179
72	CSNK1D	0.42701134
73	FGFR2	0.41406728
74	STK3	0.40890808
75	NEK9	0.40259751
76	SGK1	0.40149286
77	MAP3K9	0.39345913
78	CDK3	0.38820321
79	MAP3K2	0.38535933
80	SGK3	0.37674196
81	EPHA3	0.36524901
82	PIK3CG	0.36379497
83	WEE1	0.36240369
84	MAP2K6	0.36030083
85	TIE1	0.35641242
86	PRKCH	0.34853756
87	PDGFRB	0.32347076
88	PRKCQ	0.31654164
89	PRKACA	0.31179872
90	PRKCZ	0.30547974
91	CSNK1G2	0.30004675
92	PLK4	0.29348769
93	NLK	0.29041050
94	CAMK2B	0.28941349
95	DYRK1A	0.28718868
96	BCR	0.27649413
97	RPS6KA3	0.27338036
98	PRKACB	0.26319936
99	RET	0.25590325
100	PRKG1	0.25508179

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.43678631
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.68398598
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.65232474
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.63826282
5	Phototransduction_Homo sapiens_hsa04744	2.56744386
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.30844949
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.19973871
8	Taste transduction_Homo sapiens_hsa04742	2.10128738
9	Butanoate metabolism_Homo sapiens_hsa00650	2.05126097
10	Morphine addiction_Homo sapiens_hsa05032	2.03632363
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.01179822
12	Ether lipid metabolism_Homo sapiens_hsa00565	1.88673411
13	Glutamatergic synapse_Homo sapiens_hsa04724	1.87200790
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.82858128
15	Circadian entrainment_Homo sapiens_hsa04713	1.81813519
16	ABC transporters_Homo sapiens_hsa02010	1.74274211
17	Olfactory transduction_Homo sapiens_hsa04740	1.71725501
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.70504014
19	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.65978303
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.63202200
21	Serotonergic synapse_Homo sapiens_hsa04726	1.61804752
22	GABAergic synapse_Homo sapiens_hsa04727	1.55217062
23	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.53073851
24	Insulin secretion_Homo sapiens_hsa04911	1.49662058
25	Long-term depression_Homo sapiens_hsa04730	1.45386401
26	Calcium signaling pathway_Homo sapiens_hsa04020	1.43493824
27	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.41928053
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.37398370
29	Cocaine addiction_Homo sapiens_hsa05030	1.32378550
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.23498591
31	Histidine metabolism_Homo sapiens_hsa00340	1.19528916
32	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.17948799
33	Cholinergic synapse_Homo sapiens_hsa04725	1.13928011
34	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.10726512
35	Salivary secretion_Homo sapiens_hsa04970	1.10205946
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.09041470
37	Gastric acid secretion_Homo sapiens_hsa04971	1.07806395
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05309693
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.03254586
40	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03049780
41	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.00335254
42	Amphetamine addiction_Homo sapiens_hsa05031	0.99156984
43	Circadian rhythm_Homo sapiens_hsa04710	0.96682144
44	Glycerolipid metabolism_Homo sapiens_hsa00561	0.94335819
45	cAMP signaling pathway_Homo sapiens_hsa04024	0.93108746
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.91040144
47	Caffeine metabolism_Homo sapiens_hsa00232	0.89847435
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.87909490
49	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.87519868
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.86456668
51	Type II diabetes mellitus_Homo sapiens_hsa04930	0.86075748
52	Lysine degradation_Homo sapiens_hsa00310	0.82526337
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81983444
54	Homologous recombination_Homo sapiens_hsa03440	0.81715540
55	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.81486562
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.81148708
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80047903
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79858810
59	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.76842356
60	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.73329745
61	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72969409
62	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.72836752
63	MAPK signaling pathway_Homo sapiens_hsa04010	0.69488572
64	Axon guidance_Homo sapiens_hsa04360	0.68190005
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.67783000
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.67245436
67	Renin secretion_Homo sapiens_hsa04924	0.64897080
68	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.64532487
69	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.62893217
70	Retinol metabolism_Homo sapiens_hsa00830	0.56909743
71	Ras signaling pathway_Homo sapiens_hsa04014	0.56462309
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55722178
73	Pancreatic secretion_Homo sapiens_hsa04972	0.55605212
74	Bile secretion_Homo sapiens_hsa04976	0.55432305
75	Estrogen signaling pathway_Homo sapiens_hsa04915	0.52601584
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.49661820
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.49589339
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49148509
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48800010
80	Melanoma_Homo sapiens_hsa05218	0.48445298
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.47333386
82	Peroxisome_Homo sapiens_hsa04146	0.46916452
83	FoxO signaling pathway_Homo sapiens_hsa04068	0.46296250
84	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.45709716
85	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.45665554
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.45269733
87	Basal transcription factors_Homo sapiens_hsa03022	0.44163579
88	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.42811330
89	Mineral absorption_Homo sapiens_hsa04978	0.41434742
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.40963751
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.40928754
92	Asthma_Homo sapiens_hsa05310	0.40197317
93	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.37299326
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36953431
95	Regulation of autophagy_Homo sapiens_hsa04140	0.36688924
96	Choline metabolism in cancer_Homo sapiens_hsa05231	0.33871800
97	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.32868524
98	GnRH signaling pathway_Homo sapiens_hsa04912	0.31317538
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.31198326
100	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.29719821

KPNA5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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