KPNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.40886661
2nuclear pore complex assembly (GO:0051292)6.39849944
3nuclear pore organization (GO:0006999)6.07221422
4heterochromatin organization (GO:0070828)5.38495938
5pre-miRNA processing (GO:0031054)5.23634224
6mitotic sister chromatid segregation (GO:0000070)5.02284135
7DNA unwinding involved in DNA replication (GO:0006268)5.00293302
8DNA replication-dependent nucleosome assembly (GO:0006335)4.96577348
9DNA replication-dependent nucleosome organization (GO:0034723)4.96577348
10protein localization to chromosome, centromeric region (GO:0071459)4.95803834
11sister chromatid segregation (GO:0000819)4.83864653
12pore complex assembly (GO:0046931)4.72026562
13chromatin assembly (GO:0031497)4.66643159
14regulation of telomere maintenance via telomerase (GO:0032210)4.58288530
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.47867629
16regulation of posttranscriptional gene silencing (GO:0060147)4.41855243
17regulation of gene silencing by miRNA (GO:0060964)4.41855243
18regulation of gene silencing by RNA (GO:0060966)4.41855243
19DNA strand elongation involved in DNA replication (GO:0006271)4.30963287
20DNA duplex unwinding (GO:0032508)4.24911592
21DNA geometric change (GO:0032392)4.21729450
22DNA strand elongation (GO:0022616)4.19250418
23establishment of integrated proviral latency (GO:0075713)4.17684867
24mitotic chromosome condensation (GO:0007076)4.12747557
25histone H4-K12 acetylation (GO:0043983)4.10236267
26polyketide metabolic process (GO:0030638)4.07915480
27doxorubicin metabolic process (GO:0044598)4.07915480
28daunorubicin metabolic process (GO:0044597)4.07915480
29negative regulation of cell cycle G2/M phase transition (GO:1902750)4.04550283
30RNA stabilization (GO:0043489)4.02666403
31mRNA stabilization (GO:0048255)4.02666403
32regulation of nuclear cell cycle DNA replication (GO:0033262)4.00067897
33DNA topological change (GO:0006265)3.98801712
34histone H4-K8 acetylation (GO:0043982)3.96174515
35histone H4-K5 acetylation (GO:0043981)3.96174515
36mitotic nuclear envelope disassembly (GO:0007077)3.95753032
37negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.94115504
38regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.83397714
39protein complex localization (GO:0031503)3.81104930
40negative regulation of epidermis development (GO:0045683)3.76049887
41regulation of nucleobase-containing compound transport (GO:0032239)3.75486590
42nuclear envelope disassembly (GO:0051081)3.74508870
43membrane disassembly (GO:0030397)3.74508870
44folic acid-containing compound biosynthetic process (GO:0009396)3.71280352
45notochord development (GO:0030903)3.62656646
46regulation of mammary gland epithelial cell proliferation (GO:0033599)3.59658210
47cellular protein complex localization (GO:0034629)3.59653550
48telomere maintenance via semi-conservative replication (GO:0032201)3.57583056
49DNA replication checkpoint (GO:0000076)3.57210742
50negative regulation of telomerase activity (GO:0051974)3.56574152
51negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.51662119
52mitotic sister chromatid cohesion (GO:0007064)3.48044678
53maturation of SSU-rRNA (GO:0030490)3.47589564
54maintenance of protein location in nucleus (GO:0051457)3.45263234
55DNA replication initiation (GO:0006270)3.44969142
56formation of translation preinitiation complex (GO:0001731)3.44491075
57metaphase plate congression (GO:0051310)3.42409534
58spliceosomal tri-snRNP complex assembly (GO:0000244)3.41118284
59ribosomal small subunit biogenesis (GO:0042274)3.34387614
60negative regulation of DNA repair (GO:0045738)3.33278561
61DNA packaging (GO:0006323)3.30269744
62protein export from nucleus (GO:0006611)3.29017009
63negative regulation of histone methylation (GO:0031061)3.28650648
64rRNA transcription (GO:0009303)3.27794539
65DNA conformation change (GO:0071103)3.26135390
66regulation of histone H3-K9 methylation (GO:0051570)3.22810204
67positive regulation of DNA-dependent DNA replication (GO:2000105)3.22594208
68trophectodermal cell differentiation (GO:0001829)3.22071069
69histone H4-K16 acetylation (GO:0043984)3.21894946
70establishment of chromosome localization (GO:0051303)3.21788947
71regulation of translational fidelity (GO:0006450)3.21074135
72regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20884089
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.20547994
74protein localization to chromosome (GO:0034502)3.18361734
75paraxial mesoderm development (GO:0048339)3.18338222
76regulation of hippo signaling (GO:0035330)3.18162899
77IMP biosynthetic process (GO:0006188)3.17716934
78chromatin assembly or disassembly (GO:0006333)3.16547221
79regulation of centriole replication (GO:0046599)3.14402757
80ribosome assembly (GO:0042255)3.12464082
81regulation of DNA endoreduplication (GO:0032875)3.11794247
82chromosome condensation (GO:0030261)3.09190764
83regulation of translation in response to stress (GO:0043555)3.07872962
84somite rostral/caudal axis specification (GO:0032525)3.07686040
85regulation of response to osmotic stress (GO:0047484)3.05024612
86telomere maintenance via recombination (GO:0000722)3.03613267
87mitotic recombination (GO:0006312)3.02802812
88regulation of RNA export from nucleus (GO:0046831)3.01735858
89negative regulation of mRNA metabolic process (GO:1903312)3.00814044
90establishment of viral latency (GO:0019043)3.00066537
91spindle assembly (GO:0051225)2.99212049
92muscle organ morphogenesis (GO:0048644)2.98352913
93regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.98125664
94ATP-dependent chromatin remodeling (GO:0043044)2.97808399
95DNA synthesis involved in DNA repair (GO:0000731)2.97687168
96regulation of gene silencing (GO:0060968)2.97449316
97double-strand break repair via nonhomologous end joining (GO:0006303)2.96758527
98non-recombinational repair (GO:0000726)2.96758527
99regulation of double-strand break repair (GO:2000779)2.95506895
100ribosome biogenesis (GO:0042254)2.95391970
101mitotic metaphase plate congression (GO:0007080)2.94472777
102histone H2B ubiquitination (GO:0033523)2.93296876
103nucleosome disassembly (GO:0006337)2.91374669
104protein-DNA complex disassembly (GO:0032986)2.91374669
105negative regulation of mRNA processing (GO:0050686)2.91068602
106cell fate commitment involved in formation of primary germ layer (GO:0060795)2.89879650
107regulation of mRNA stability (GO:0043488)2.89119088
108chromosome segregation (GO:0007059)2.88555754
109histone H2A monoubiquitination (GO:0035518)2.88530146
110nuclear envelope organization (GO:0006998)2.86467963
111positive regulation of SMAD protein import into nucleus (GO:0060391)2.84546118
112regulation of sister chromatid cohesion (GO:0007063)2.84368021
113regulation of centrosome cycle (GO:0046605)2.84361930
114regulation of translational termination (GO:0006449)2.82673790
115regulation of telomere maintenance (GO:0032204)2.82486634
116dosage compensation (GO:0007549)2.78319353
117peptidyl-arginine omega-N-methylation (GO:0035247)2.77718347
118regulation of spindle organization (GO:0090224)2.77580486
119ribonucleoprotein complex biogenesis (GO:0022613)2.76958973
120positive regulation of chromosome segregation (GO:0051984)2.76786478
121IMP metabolic process (GO:0046040)2.75790338
122negative regulation of gene silencing (GO:0060969)2.75341577
123negative regulation of RNA splicing (GO:0033119)2.75262291
124regulation of mitotic spindle organization (GO:0060236)2.74839816
125kinetochore organization (GO:0051383)2.74824174
126mitotic cytokinesis (GO:0000281)2.74768218
127protein localization to microtubule (GO:0035372)2.74475873
128maternal placenta development (GO:0001893)2.73024263
129mRNA transport (GO:0051028)2.70236383
130polarized epithelial cell differentiation (GO:0030859)2.70223440
131negative regulation of epidermal cell differentiation (GO:0045605)2.70186866
132regulation of DNA-dependent DNA replication (GO:0090329)2.68796123
133CENP-A containing nucleosome assembly (GO:0034080)2.68731069
134histone arginine methylation (GO:0034969)2.68694178
135regulation of DNA damage checkpoint (GO:2000001)2.67889215
136regulation of chromosome segregation (GO:0051983)2.67859136
137regulation of RNA stability (GO:0043487)2.67061226
138DNA replication-independent nucleosome assembly (GO:0006336)2.66013878
139DNA replication-independent nucleosome organization (GO:0034724)2.66013878
140attachment of spindle microtubules to kinetochore (GO:0008608)2.65444604
141chromatin remodeling at centromere (GO:0031055)2.65273282
142spindle assembly checkpoint (GO:0071173)2.64071492
143negative regulation of chromosome segregation (GO:0051985)2.63604839
144mitotic G2/M transition checkpoint (GO:0044818)2.63462460
145intestinal epithelial cell development (GO:0060576)2.62654008
146anterior/posterior axis specification, embryo (GO:0008595)2.62579383
147regulation of histone H3-K27 methylation (GO:0061085)2.62109464
148spindle organization (GO:0007051)2.61303064
149nucleobase-containing small molecule interconversion (GO:0015949)2.61204869
150spindle checkpoint (GO:0031577)2.57237466
151ribosomal large subunit biogenesis (GO:0042273)2.56975565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.74677066
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.47472450
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.11258346
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.11258346
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.11258346
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65393625
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.99950890
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.99433525
9* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80868462
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.79923965
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.64746999
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.58426173
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.57030216
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.52310189
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.40661312
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33870291
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.19343088
18* MYC_22102868_ChIP-Seq_BL_Human2.16154832
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11131487
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09740595
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08790542
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.07080019
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05836240
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03626261
25TCF3_18692474_ChIP-Seq_MESCs_Mouse1.99651668
26AR_21909140_ChIP-Seq_LNCAP_Human1.98381073
27SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91334325
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.88344880
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82683318
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81855187
31STAT3_1855785_ChIP-Seq_MESCs_Mouse1.79342572
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77324049
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.76000176
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68774779
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67773063
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.67126999
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.66845617
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65120337
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62793068
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61333002
41KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61016953
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.60760567
43* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.59663726
44* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59234390
45* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57812634
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57321635
47* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.53761201
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52550198
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.50467278
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49080429
51ZNF263_19887448_ChIP-Seq_K562_Human1.47604120
52DCP1A_22483619_ChIP-Seq_HELA_Human1.45938814
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45884825
54* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45087392
55CLOCK_20551151_ChIP-Seq_293T_Human1.43772323
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42957892
57* XRN2_22483619_ChIP-Seq_HELA_Human1.40081351
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.38626076
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.34299806
60* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30500113
61* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28572081
62* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28387728
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27686914
64* NANOG_21062744_ChIP-ChIP_HESCs_Human1.23305916
65KDM5A_27292631_Chip-Seq_BREAST_Human1.22887970
66* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.22803959
67NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22560275
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22094004
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18316643
70* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17589469
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16729889
72* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14559958
73SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14254759
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13822244
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12632277
76CIITA_25753668_ChIP-Seq_RAJI_Human1.11636691
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10709605
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10576925
79* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.09597276
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.09231148
81KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08989450
82RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08622835
83* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08530244
84* TCF7_22412390_ChIP-Seq_EML_Mouse1.08129292
85* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07530740
86EST1_17652178_ChIP-ChIP_JURKAT_Human1.06556446
87* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05865478
88NANOG_16153702_ChIP-ChIP_HESCs_Human1.05127804
89* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.04865592
90* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.04740699
91* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03970374
92TTF2_22483619_ChIP-Seq_HELA_Human1.03687780
93NCOR1_26117541_ChIP-Seq_K562_Human1.02540301
94SOX2_18692474_ChIP-Seq_MEFs_Mouse1.02366467
95SOX17_20123909_ChIP-Seq_XEN_Mouse1.02268113
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02227560
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01865814
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.01255416
99* VDR_21846776_ChIP-Seq_THP-1_Human1.00777877
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99894265
101FOXP3_21729870_ChIP-Seq_TREG_Human0.99049387
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.98349750
103SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98139989
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98004415
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97996376
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97854456
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97787115
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97276253
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96933428
110PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.96914580
111* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96082218
112* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95057246
113TFEB_21752829_ChIP-Seq_HELA_Human0.95005873
114* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94598560
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93363774
116* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93016798
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.92997431
118* ATF3_27146783_Chip-Seq_COLON_Human0.92715646
119PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92661682
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92444036
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92108658
122* CHD1_26751641_Chip-Seq_LNCaP_Human0.90104022
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.90101212
124RACK7_27058665_Chip-Seq_MCF-7_Human0.89883943
125ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89808568
126TP53_22127205_ChIP-Seq_IMR90_Human0.89785325
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89566164
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.88743478
129ETS1_20019798_ChIP-Seq_JURKAT_Human0.88691191
130* NANOG_16518401_ChIP-PET_MESCs_Mouse0.88466916
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.88186251
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87033197
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85951215
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85039819
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85021406
136GABP_19822575_ChIP-Seq_HepG2_Human0.84741926

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.56238737
2MP0004957_abnormal_blastocyst_morpholog3.43780786
3MP0010352_gastrointestinal_tract_polyps3.41905861
4MP0008057_abnormal_DNA_replication3.23777925
5MP0004264_abnormal_extraembryonic_tissu2.86954213
6MP0003890_abnormal_embryonic-extraembry2.86526257
7MP0003111_abnormal_nucleus_morphology2.70249720
8MP0010094_abnormal_chromosome_stability2.67883392
9MP0003123_paternal_imprinting2.60936288
10MP0003077_abnormal_cell_cycle2.59460967
11MP0003121_genomic_imprinting2.49245773
12MP0001672_abnormal_embryogenesis/_devel2.27735793
13MP0005380_embryogenesis_phenotype2.27735793
14MP0010030_abnormal_orbit_morphology2.21364646
15MP0003693_abnormal_embryo_hatching2.21060909
16MP0000350_abnormal_cell_proliferation2.18846837
17MP0001730_embryonic_growth_arrest2.14692118
18MP0003984_embryonic_growth_retardation2.12242731
19MP0002088_abnormal_embryonic_growth/wei2.12002230
20MP0003122_maternal_imprinting2.07534235
21MP0003941_abnormal_skin_development2.04975912
22MP0002084_abnormal_developmental_patter1.99697897
23MP0004197_abnormal_fetal_growth/weight/1.98617049
24MP0002085_abnormal_embryonic_tissue1.91882561
25MP0002086_abnormal_extraembryonic_tissu1.90225492
26MP0004233_abnormal_muscle_weight1.82716082
27MP0005076_abnormal_cell_differentiation1.81998994
28MP0001293_anophthalmia1.77300799
29MP0001697_abnormal_embryo_size1.71669061
30MP0006292_abnormal_olfactory_placode1.68598990
31MP0001849_ear_inflammation1.67941097
32MP0002653_abnormal_ependyma_morphology1.67138045
33MP0008932_abnormal_embryonic_tissue1.65623175
34MP0002009_preneoplasia1.65527989
35MP0008007_abnormal_cellular_replicative1.60110166
36MP0002254_reproductive_system_inflammat1.56522514
37MP0005394_taste/olfaction_phenotype1.54849999
38MP0005499_abnormal_olfactory_system1.54849999
39MP0010307_abnormal_tumor_latency1.53400457
40MP0003119_abnormal_digestive_system1.51222098
41MP0005257_abnormal_intraocular_pressure1.50946081
42MP0005623_abnormal_meninges_morphology1.50661005
43MP0000428_abnormal_craniofacial_morphol1.49509645
44MP0002092_abnormal_eye_morphology1.48903348
45* MP0002080_prenatal_lethality1.48110059
46MP0002396_abnormal_hematopoietic_system1.46905649
47MP0004858_abnormal_nervous_system1.41462974
48MP0000537_abnormal_urethra_morphology1.36663276
49MP0003937_abnormal_limbs/digits/tail_de1.33438228
50MP0003566_abnormal_cell_adhesion1.32745747
51MP0003011_delayed_dark_adaptation1.31670702
52MP0002932_abnormal_joint_morphology1.27665814
53MP0009703_decreased_birth_body1.26446477
54MP0003283_abnormal_digestive_organ1.25926205
55MP0003935_abnormal_craniofacial_develop1.23572562
56MP0009053_abnormal_anal_canal1.23372705
57MP0000432_abnormal_head_morphology1.23252817
58MP0005023_abnormal_wound_healing1.20515387
59MP0002925_abnormal_cardiovascular_devel1.14923728
60MP0010234_abnormal_vibrissa_follicle1.13553729
61MP0002877_abnormal_melanocyte_morpholog1.10641026
62MP0009697_abnormal_copulation1.10502195
63MP0003115_abnormal_respiratory_system1.10430551
64MP0000733_abnormal_muscle_development1.10160998
65MP0003755_abnormal_palate_morphology1.08723066
66MP0000313_abnormal_cell_death1.08698692
67MP0008058_abnormal_DNA_repair1.08320212
68MP0002697_abnormal_eye_size1.08311434
69MP0005409_darkened_coat_color1.06425638
70MP0001346_abnormal_lacrimal_gland1.06328619
71MP0002233_abnormal_nose_morphology1.05388107
72MP0000490_abnormal_crypts_of1.05187660
73MP0002796_impaired_skin_barrier1.04605496
74MP0002111_abnormal_tail_morphology1.04243725
75MP0005501_abnormal_skin_physiology1.02812527
76MP0005451_abnormal_body_composition1.02211647
77MP0008770_decreased_survivor_rate1.02089120
78MP0002114_abnormal_axial_skeleton1.01475942
79MP0001348_abnormal_lacrimal_gland1.00916557
80MP0009379_abnormal_foot_pigmentation1.00791625
81MP0000579_abnormal_nail_morphology1.00526857
82MP0002089_abnormal_postnatal_growth/wei0.98804629
83MP0003567_abnormal_fetal_cardiomyocyte0.98736863
84MP0009672_abnormal_birth_weight0.97362970
85MP0003938_abnormal_ear_development0.97316311
86MP0005621_abnormal_cell_physiology0.95045680
87MP0002332_abnormal_exercise_endurance0.94440815
88MP0000049_abnormal_middle_ear0.93843276
89MP0008961_abnormal_basal_metabolism0.93390546
90MP0001299_abnormal_eye_distance/0.91910901
91MP0005248_abnormal_Harderian_gland0.91614626
92MP0008438_abnormal_cutaneous_collagen0.91607151
93MP0001286_abnormal_eye_development0.91038546
94MP0000762_abnormal_tongue_morphology0.90462536
95MP0002127_abnormal_cardiovascular_syste0.90310034
96MP0003221_abnormal_cardiomyocyte_apopto0.89927147
97MP0004272_abnormal_basement_membrane0.89509790
98MP0004133_heterotaxia0.88864910
99MP0003861_abnormal_nervous_system0.88746735
100MP0003453_abnormal_keratinocyte_physiol0.87901351
101MP0002060_abnormal_skin_morphology0.87836733
102MP0003787_abnormal_imprinting0.87282422
103MP0004808_abnormal_hematopoietic_stem0.86352196
104MP0001661_extended_life_span0.85660281
105MP0001915_intracranial_hemorrhage0.84491051
106MP0003315_abnormal_perineum_morphology0.84116511
107MP0010630_abnormal_cardiac_muscle0.82680973
108MP0002116_abnormal_craniofacial_bone0.82548768
109MP0000678_abnormal_parathyroid_gland0.81965984
110MP0000534_abnormal_ureter_morphology0.80708709
111MP0002019_abnormal_tumor_incidence0.80608974
112MP0005508_abnormal_skeleton_morphology0.78337382
113MP0003942_abnormal_urinary_system0.77324787
114MP0004185_abnormal_adipocyte_glucose0.77246926
115MP0000358_abnormal_cell_content/0.76266969
116MP0000627_abnormal_mammary_gland0.76083485
117MP0008789_abnormal_olfactory_epithelium0.75900118
118MP0003385_abnormal_body_wall0.75172381
119MP0003091_abnormal_cell_migration0.75140073
120MP0005384_cellular_phenotype0.74919423
121MP0000566_synostosis0.74476709
122MP0000266_abnormal_heart_morphology0.73114709
123MP0003950_abnormal_plasma_membrane0.72462282
124MP0002081_perinatal_lethality0.72227161
125MP0003786_premature_aging0.71896548
126MP0010678_abnormal_skin_adnexa0.69851569
127MP0001340_abnormal_eyelid_morphology0.69564115

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.81857652
2Bilateral microphthalmos (HP:0007633)4.53843856
3Hypochromic microcytic anemia (HP:0004840)3.78353020
4Abnormality of the astrocytes (HP:0100707)3.77349624
5Astrocytoma (HP:0009592)3.77349624
6Rhabdomyosarcoma (HP:0002859)3.67126331
7Abnormality of the lower motor neuron (HP:0002366)3.62561934
8Neoplasm of striated muscle (HP:0009728)3.57446450
9Rib fusion (HP:0000902)3.53843804
10Multiple enchondromatosis (HP:0005701)3.48519848
11Hepatoblastoma (HP:0002884)3.38308583
12Hyperacusis (HP:0010780)3.24979155
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.96672277
14Medulloblastoma (HP:0002885)2.93973356
15Glioma (HP:0009733)2.88773047
16Chromsome breakage (HP:0040012)2.88162062
17Short humerus (HP:0005792)2.78679548
18Renal duplication (HP:0000075)2.75919460
19Aplasia/hypoplasia of the humerus (HP:0006507)2.74178296
20Nephroblastoma (Wilms tumor) (HP:0002667)2.73642928
21Fused cervical vertebrae (HP:0002949)2.72341189
22Selective tooth agenesis (HP:0001592)2.70778579
23Asymmetry of the thorax (HP:0001555)2.67559718
24Volvulus (HP:0002580)2.66629766
25Insomnia (HP:0100785)2.59927392
26Embryonal renal neoplasm (HP:0011794)2.56391890
27Pseudobulbar signs (HP:0002200)2.55807138
28Increased nuchal translucency (HP:0010880)2.54569434
29Missing ribs (HP:0000921)2.46675941
30Preauricular skin tag (HP:0000384)2.45409645
31Cortical dysplasia (HP:0002539)2.45195388
32Neoplasm of the oral cavity (HP:0100649)2.43775377
33Ankyloglossia (HP:0010296)2.43528948
34Impulsivity (HP:0100710)2.41161667
35Skin tags (HP:0010609)2.40365937
36Abnormality of the salivary glands (HP:0010286)2.39621001
37Abnormal lung lobation (HP:0002101)2.39001409
38Large earlobe (HP:0009748)2.37947402
39Reticulocytopenia (HP:0001896)2.37066778
40Deep philtrum (HP:0002002)2.32865115
41Trismus (HP:0000211)2.31337999
42Hypopigmentation of the fundus (HP:0007894)2.30360163
43High anterior hairline (HP:0009890)2.28966512
44Atresia of the external auditory canal (HP:0000413)2.28521763
45Insidious onset (HP:0003587)2.27599353
46Termporal pattern (HP:0011008)2.27599353
47Amyotrophic lateral sclerosis (HP:0007354)2.24587491
48Deviation of the thumb (HP:0009603)2.23053147
49Overriding aorta (HP:0002623)2.22711490
50Abnormality of the distal phalanx of the thumb (HP:0009617)2.22378199
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.20617450
52Meckel diverticulum (HP:0002245)2.19863702
53Abnormality of the labia minora (HP:0012880)2.19632310
54Shawl scrotum (HP:0000049)2.19545400
55Proximal placement of thumb (HP:0009623)2.19083909
56Duplication of thumb phalanx (HP:0009942)2.17452345
57Overlapping toe (HP:0001845)2.16734898
58Elfin facies (HP:0004428)2.15422065
59Supernumerary ribs (HP:0005815)2.14573126
60Increased connective tissue (HP:0009025)2.13642107
61Abnormality of the calcaneus (HP:0008364)2.12892971
62Progressive muscle weakness (HP:0003323)2.11845827
63Spinal cord lesions (HP:0100561)2.11410074
64Syringomyelia (HP:0003396)2.11410074
65Adenoma sebaceum (HP:0009720)2.09041209
66Angiofibromas (HP:0010615)2.09041209
67Rectovaginal fistula (HP:0000143)2.09014908
68Rectal fistula (HP:0100590)2.09014908
69Gastrointestinal carcinoma (HP:0002672)2.08468008
70Malignant gastrointestinal tract tumors (HP:0006749)2.08468008
71Progressive external ophthalmoplegia (HP:0000590)2.07609731
72Supernumerary spleens (HP:0009799)2.07195969
73Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06945648
74Short 4th metacarpal (HP:0010044)2.06945648
75Abnormality of chromosome segregation (HP:0002916)2.06438742
7611 pairs of ribs (HP:0000878)2.05816031
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.05302548
78Disproportionate tall stature (HP:0001519)2.04384942
79Abnormality of oral frenula (HP:0000190)2.04352430
80Short 5th finger (HP:0009237)2.04133892
81Abnormality of the ileum (HP:0001549)2.03027710
82Broad thumb (HP:0011304)2.01987133
83Premature rupture of membranes (HP:0001788)2.00994714
84Vertebral fusion (HP:0002948)1.98729634
85Hand muscle atrophy (HP:0009130)1.97029475
86Vertebral arch anomaly (HP:0008438)1.96922994
87Urethral obstruction (HP:0000796)1.96478668
88Birth length less than 3rd percentile (HP:0003561)1.96397855
89Intestinal fistula (HP:0100819)1.95777448
90Supernumerary bones of the axial skeleton (HP:0009144)1.95441952
91Patellar dislocation (HP:0002999)1.95006769
92Small intestinal stenosis (HP:0012848)1.94186021
93Duodenal stenosis (HP:0100867)1.94186021
94Colon cancer (HP:0003003)1.93652942
95Bifid tongue (HP:0010297)1.93067109
96Long eyelashes (HP:0000527)1.92883888
97Resting tremor (HP:0002322)1.92232046
98Ulnar bowing (HP:0003031)1.91585332
99Flat acetabular roof (HP:0003180)1.91096684
100Protrusio acetabuli (HP:0003179)1.90117267
101Malignant neoplasm of the central nervous system (HP:0100836)1.89700783
102Abnormality of the preputium (HP:0100587)1.86394466
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86248286
104Long palpebral fissure (HP:0000637)1.84961636
105Abnormality of the phalanges of the hallux (HP:0010057)1.83893648
106Heterotopia (HP:0002282)1.83826848
107Obsessive-compulsive behavior (HP:0000722)1.83793367
108Dysmetric saccades (HP:0000641)1.83363253
109Glossoptosis (HP:0000162)1.83282135
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.82675414
111Ectopic kidney (HP:0000086)1.82466266
112Abnormality of the carotid arteries (HP:0005344)1.80084835
113Broad palm (HP:0001169)1.79971956
114Arnold-Chiari malformation (HP:0002308)1.79413852
115Abnormal cartilage morphology (HP:0002763)1.79352856
116Fibroma (HP:0010614)1.79265301
117Sparse lateral eyebrow (HP:0005338)1.79049049
118Deep palmar crease (HP:0006191)1.75995137
119Atrophy/Degeneration involving motor neurons (HP:0007373)1.75764215
120Spastic diplegia (HP:0001264)1.75665825
121Abnormality of chromosome stability (HP:0003220)1.75251392
122Abnormal number of incisors (HP:0011064)1.75053839
123Fibrous tissue neoplasm (HP:0012316)1.74711159
124Distal upper limb amyotrophy (HP:0007149)1.74155575
125Upper limb amyotrophy (HP:0009129)1.74155575
126Prominent nose (HP:0000448)1.73163654
127Achilles tendon contracture (HP:0001771)1.73109796
128Vaginal fistula (HP:0004320)1.72966706
129Cafe-au-lait spot (HP:0000957)1.71780079
130Absent frontal sinuses (HP:0002688)1.71752000
131Abnormality of the musculature of the hand (HP:0001421)1.70847641
132Leiomyosarcoma (HP:0100243)1.70407732
133Uterine leiomyosarcoma (HP:0002891)1.70407732
134Renovascular hypertension (HP:0100817)1.69056063
135Skull defect (HP:0001362)1.68989826
136Partial duplication of the phalanx of hand (HP:0009999)1.68629576
137Difficulty running (HP:0009046)1.68386319
138Abnormality of cochlea (HP:0000375)1.67567750
139Prominent occiput (HP:0000269)1.67056503
140Shallow orbits (HP:0000586)1.66825739
141Limited elbow extension (HP:0001377)1.66559247
142Myelodysplasia (HP:0002863)1.66247412
143Neoplasm of the heart (HP:0100544)1.66096390
144Choanal atresia (HP:0000453)1.65894926
145Relative macrocephaly (HP:0004482)1.64218796
146Pointed chin (HP:0000307)1.63160175
147Sandal gap (HP:0001852)1.63008126
148Aplasia/Hypoplasia of the sacrum (HP:0008517)1.61561821
149Flat cornea (HP:0007720)1.61334341
150Absent radius (HP:0003974)1.61198075
151Abnormal foot bone ossification (HP:0010675)1.61105058
152Coronal craniosynostosis (HP:0004440)1.60252814
153Facial cleft (HP:0002006)1.59362310
154Short nail (HP:0001799)1.57372336
155Osteolytic defects of the hand bones (HP:0009699)1.55723125
156Osteolytic defects of the phalanges of the hand (HP:0009771)1.55723125
157Orthostatic hypotension (HP:0001278)1.55310696
158Abnormality of the parietal bone (HP:0002696)1.53013809
159Trigonocephaly (HP:0000243)1.52778231
160Ankle contracture (HP:0006466)1.52638922
161Abnormality of the umbilical cord (HP:0010881)1.51762853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.76379594
2SMG13.17967980
3CDC73.13916239
4TTK2.94615765
5ERN12.36450835
6STK102.31908291
7GRK62.30231218
8MAP3K102.13901807
9NEK22.08236523
10EEF2K2.04722601
11GRK52.01622179
12TYRO31.99419892
13EPHA21.94729379
14EIF2AK11.92409338
15WEE11.84663432
16PNCK1.78861302
17PKN21.78119186
18CDK71.75646554
19TAF11.74159367
20CSF1R1.69757299
21PAK41.64859038
22NEK11.64812684
23ALK1.64318881
24PBK1.61582759
25RPS6KB21.60257282
26PLK11.50413254
27LATS11.49076696
28CHEK21.43278407
29CAMK1G1.41266134
30TRIB31.40995855
31IRAK31.37893921
32CHEK11.37162909
33FGFR41.34002299
34LATS21.31095053
35TGFBR21.29197910
36MTOR1.28517887
37CDK41.27144891
38PDGFRA1.26905458
39SCYL21.25002780
40MST1R1.21125819
41BRD41.14288646
42NME21.14218091
43WNK11.13947041
44BUB11.13500127
45TTN1.12477560
46PLK41.10636389
47MAP3K81.09879749
48PRPF4B1.07827059
49AURKB1.07625853
50PASK1.04643617
51MOS1.03698440
52MAP3K90.98762873
53SRPK10.97086000
54TSSK60.96055127
55MAPK70.95756801
56CLK10.95481380
57CDK60.93712489
58ATR0.93577476
59FGFR30.92717060
60CDK20.92682312
61STK30.92399350
62ATM0.89008755
63ERBB40.88368267
64MATK0.88274959
65PAK20.88081609
66RIPK10.86753551
67MKNK10.85183906
68ICK0.85182832
69BRSK10.84636320
70BMX0.79863432
71AKT20.79762893
72CDK80.79727063
73VRK20.79629880
74GRK10.79271528
75BRAF0.78026718
76KSR20.75433446
77PLK30.70300884
78PRKG20.66125044
79AURKA0.66048874
80TESK20.66048129
81CSNK1E0.65228102
82CDK10.64811253
83DDR20.64749122
84EIF2AK20.64162441
85CAMK40.63989781
86ADRBK20.62546679
87PTK20.61099356
88BRSK20.60115305
89MET0.58795028
90FGFR10.58724395
91MELK0.57995656
92STK40.57410375
93KSR10.57135193
94LRRK20.55884019
95PTK60.55832924
96CAMK1D0.55063462
97FLT30.54752817
98HIPK20.54618434
99TGFBR10.52702689
100CSNK1D0.51844463
101PAK10.51417177
102NEK90.50280330
103CDK90.49891779
104DMPK0.49887766
105RPS6KA40.47469578
106MARK20.47171052
107NTRK10.45402013
108EIF2AK30.44581125
109CDK11A0.44211513
110DYRK30.43649260
111ACVR1B0.43580886
112CDK150.42990164
113MAPK140.42804767
114ADRBK10.41511410
115CDK180.40299305
116PRKCI0.40169856
117SIK10.39775722
118MKNK20.39347617
119MAPK10.38160135
120CSNK2A20.37802571
121YES10.37005179
122PDGFRB0.36643065
123GSK3B0.35226509
124MAP3K130.35049997
125MAP3K70.34773662
126PRKDC0.34349946
127MAPK100.34025459
128STK240.33321660
129ERBB20.33138096
130AKT30.32107960
131CDK140.31985467
132CSK0.31644209
133PIM10.30996625
134AKT10.30054049

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.90769411
2DNA replication_Homo sapiens_hsa030303.07614320
3* RNA transport_Homo sapiens_hsa030133.06229226
4One carbon pool by folate_Homo sapiens_hsa006702.79606055
5Mismatch repair_Homo sapiens_hsa034302.75371962
6Cell cycle_Homo sapiens_hsa041102.70509055
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.51940160
8Spliceosome_Homo sapiens_hsa030402.45414483
9mRNA surveillance pathway_Homo sapiens_hsa030152.42830910
10Vitamin B6 metabolism_Homo sapiens_hsa007502.39185926
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96591483
12MicroRNAs in cancer_Homo sapiens_hsa052061.72656286
13Fanconi anemia pathway_Homo sapiens_hsa034601.71606300
14mTOR signaling pathway_Homo sapiens_hsa041501.68565884
15Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.63566767
16Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.61968541
17Homologous recombination_Homo sapiens_hsa034401.58467411
18Thyroid cancer_Homo sapiens_hsa052161.58000583
19Base excision repair_Homo sapiens_hsa034101.56932197
20RNA degradation_Homo sapiens_hsa030181.55218740
21Basal cell carcinoma_Homo sapiens_hsa052171.54104576
22Nucleotide excision repair_Homo sapiens_hsa034201.52696628
23p53 signaling pathway_Homo sapiens_hsa041151.52305365
24Fructose and mannose metabolism_Homo sapiens_hsa000511.47236664
25Hippo signaling pathway_Homo sapiens_hsa043901.46728880
26Viral carcinogenesis_Homo sapiens_hsa052031.34217405
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.33472442
28Adherens junction_Homo sapiens_hsa045201.33220422
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.26700825
30Non-homologous end-joining_Homo sapiens_hsa034501.23744928
31Small cell lung cancer_Homo sapiens_hsa052221.22529517
32Proteoglycans in cancer_Homo sapiens_hsa052051.17621804
33Hedgehog signaling pathway_Homo sapiens_hsa043401.17271967
34Systemic lupus erythematosus_Homo sapiens_hsa053221.13941478
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10054870
36Bladder cancer_Homo sapiens_hsa052191.08116983
37HTLV-I infection_Homo sapiens_hsa051661.07995577
38Colorectal cancer_Homo sapiens_hsa052101.05374634
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05039180
40Chronic myeloid leukemia_Homo sapiens_hsa052201.02552237
41Oocyte meiosis_Homo sapiens_hsa041141.00785634
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96972877
43Pathways in cancer_Homo sapiens_hsa052000.95417070
44Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94841582
45Galactose metabolism_Homo sapiens_hsa000520.94431404
46Non-small cell lung cancer_Homo sapiens_hsa052230.94394381
47Selenocompound metabolism_Homo sapiens_hsa004500.93872123
48TGF-beta signaling pathway_Homo sapiens_hsa043500.92814654
49Notch signaling pathway_Homo sapiens_hsa043300.92123952
50ErbB signaling pathway_Homo sapiens_hsa040120.90724047
51Tight junction_Homo sapiens_hsa045300.89669079
52Lysine degradation_Homo sapiens_hsa003100.88795529
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88301336
54Ribosome_Homo sapiens_hsa030100.85755668
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.83435046
56Biosynthesis of amino acids_Homo sapiens_hsa012300.82038917
57Focal adhesion_Homo sapiens_hsa045100.80499900
58Wnt signaling pathway_Homo sapiens_hsa043100.79624356
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77456809
60RNA polymerase_Homo sapiens_hsa030200.77057263
61Basal transcription factors_Homo sapiens_hsa030220.76540936
62Herpes simplex infection_Homo sapiens_hsa051680.75446289
63Pancreatic cancer_Homo sapiens_hsa052120.73697508
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72180471
65Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72088600
66Acute myeloid leukemia_Homo sapiens_hsa052210.70821991
67Endometrial cancer_Homo sapiens_hsa052130.70733636
68Antigen processing and presentation_Homo sapiens_hsa046120.69540245
69Insulin signaling pathway_Homo sapiens_hsa049100.68874254
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65694697
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.65000251
72Pyrimidine metabolism_Homo sapiens_hsa002400.64862497
73Viral myocarditis_Homo sapiens_hsa054160.64077395
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63954913
75Prostate cancer_Homo sapiens_hsa052150.62334128
76AMPK signaling pathway_Homo sapiens_hsa041520.60357638
77ECM-receptor interaction_Homo sapiens_hsa045120.60225157
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59776391
79Epstein-Barr virus infection_Homo sapiens_hsa051690.58994395
80Rap1 signaling pathway_Homo sapiens_hsa040150.58295275
81Shigellosis_Homo sapiens_hsa051310.57799155
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56553332
83Apoptosis_Homo sapiens_hsa042100.56165854
84PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55921273
85N-Glycan biosynthesis_Homo sapiens_hsa005100.54849142
86Pyruvate metabolism_Homo sapiens_hsa006200.54560686
87Prion diseases_Homo sapiens_hsa050200.54286699
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54095964
89Pentose phosphate pathway_Homo sapiens_hsa000300.53778186
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53051936
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.52688544
92Alcoholism_Homo sapiens_hsa050340.51869421
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51528843
94Prolactin signaling pathway_Homo sapiens_hsa049170.50979830
95VEGF signaling pathway_Homo sapiens_hsa043700.49885491
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49665985
97HIF-1 signaling pathway_Homo sapiens_hsa040660.48771741
98Glioma_Homo sapiens_hsa052140.47309432
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46042678
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.45438966
101Renal cell carcinoma_Homo sapiens_hsa052110.45143339
102Melanoma_Homo sapiens_hsa052180.44519663
103Inositol phosphate metabolism_Homo sapiens_hsa005620.44189454
104Melanogenesis_Homo sapiens_hsa049160.43599620
105Carbon metabolism_Homo sapiens_hsa012000.43407660
106Purine metabolism_Homo sapiens_hsa002300.42753744
107Estrogen signaling pathway_Homo sapiens_hsa049150.42639493
108Fatty acid biosynthesis_Homo sapiens_hsa000610.41659731
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.41257190
110Dorso-ventral axis formation_Homo sapiens_hsa043200.40874152
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.39199567
112Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37860803
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34238975
114Hepatitis B_Homo sapiens_hsa051610.33007018
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32650891
116Arachidonic acid metabolism_Homo sapiens_hsa005900.32017969
117Choline metabolism in cancer_Homo sapiens_hsa052310.29993960

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