KPRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a proline-rich skin protein possibly involved in keratinocyte differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.57267670
2keratinocyte differentiation (GO:0030216)8.72804873
3peptide cross-linking (GO:0018149)8.56029742
4water homeostasis (GO:0030104)7.96671327
5hemidesmosome assembly (GO:0031581)7.67139453
6epidermal cell differentiation (GO:0009913)6.81573041
7keratinocyte proliferation (GO:0043616)6.61544872
8long-chain fatty acid biosynthetic process (GO:0042759)6.40002219
9skin morphogenesis (GO:0043589)6.23809729
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.16369392
11intermediate filament organization (GO:0045109)6.06841811
12epidermis development (GO:0008544)5.82366683
13glucosamine-containing compound catabolic process (GO:1901072)5.77536301
14regulation of natural killer cell differentiation (GO:0032823)5.61572399
15G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.16764814
16regulation of type B pancreatic cell apoptotic process (GO:2000674)5.06655061
17gap junction assembly (GO:0016264)4.83139675
18fatty acid elongation (GO:0030497)4.78162279
19ectoderm development (GO:0007398)4.75688108
20regulation of hypersensitivity (GO:0002883)4.45267906
21linoleic acid metabolic process (GO:0043651)4.42329561
22regulation of ruffle assembly (GO:1900027)4.39581990
23negative regulation of interleukin-17 production (GO:0032700)4.29743692
24intermediate filament cytoskeleton organization (GO:0045104)4.04074113
25keratinocyte development (GO:0003334)3.98141231
26intermediate filament-based process (GO:0045103)3.90549671
27detection of external biotic stimulus (GO:0098581)3.82423624
28lateral sprouting from an epithelium (GO:0060601)3.76860047
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.73484299
30phosphatidylcholine acyl-chain remodeling (GO:0036151)3.69978213
31lipoxygenase pathway (GO:0019372)3.69820278
32polarized epithelial cell differentiation (GO:0030859)3.63128315
33ceramide biosynthetic process (GO:0046513)3.61570222
34positive regulation of interleukin-8 secretion (GO:2000484)3.59876350
35detection of bacterium (GO:0016045)3.46419859
36positive regulation of monocyte chemotaxis (GO:0090026)3.46338918
37sphingoid metabolic process (GO:0046519)3.44092405
38negative regulation of keratinocyte proliferation (GO:0010839)3.38194140
39skin development (GO:0043588)3.37625716
40sphingosine metabolic process (GO:0006670)3.36650434
41fibrinolysis (GO:0042730)3.34398213
42negative regulation of catenin import into nucleus (GO:0035414)3.31441993
43phosphatidylinositol acyl-chain remodeling (GO:0036149)3.30135933
44detection of biotic stimulus (GO:0009595)3.25878354
45virion attachment to host cell (GO:0019062)3.21711750
46adhesion of symbiont to host cell (GO:0044650)3.21711750
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.21047494
48negative regulation of stress fiber assembly (GO:0051497)3.15660402
49epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12623286
50phosphatidylserine metabolic process (GO:0006658)3.12394051
51phosphatidylserine acyl-chain remodeling (GO:0036150)3.07165281
52negative regulation of cell fate specification (GO:0009996)3.06110794
53regulation of natural killer cell activation (GO:0032814)3.03756650
54phospholipid scrambling (GO:0017121)3.01124091
55regulation of T cell chemotaxis (GO:0010819)3.00744776
56positive regulation of T cell chemotaxis (GO:0010820)3.00744776
57keratinization (GO:0031424)22.1307154
58G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.96457083
59diol metabolic process (GO:0034311)2.96290373
60defense response to fungus (GO:0050832)2.95920934
61positive regulation of cholesterol transport (GO:0032376)2.95380615
62positive regulation of sterol transport (GO:0032373)2.95380615
63atrioventricular valve morphogenesis (GO:0003181)2.92639752
64detection of other organism (GO:0098543)2.89847767
65cellular response to calcium ion (GO:0071277)2.89490872
66sequestering of metal ion (GO:0051238)2.88178847
67regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.86972985
68hair follicle morphogenesis (GO:0031069)2.83956507
69thymic T cell selection (GO:0045061)2.83713614
70regulation of transforming growth factor beta1 production (GO:0032908)2.81939787
71antimicrobial humoral response (GO:0019730)2.79853816
72negative regulation of muscle hypertrophy (GO:0014741)2.79371197
73positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.78480191
74adhesion of symbiont to host (GO:0044406)2.78155775
75positive regulation of epidermis development (GO:0045684)2.76276697
76intestinal epithelial cell development (GO:0060576)2.75467617
77regulation of phospholipase A2 activity (GO:0032429)2.75142983
78primary alcohol catabolic process (GO:0034310)2.74528256
79regulation of receptor recycling (GO:0001919)2.74424912
80cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.74230315
81phospholipid catabolic process (GO:0009395)2.73878329
82mitotic nuclear envelope reassembly (GO:0007084)2.73493363
83nuclear envelope reassembly (GO:0031468)2.73493363
84chemical homeostasis within a tissue (GO:0048875)2.71149321
85epithelium development (GO:0060429)2.69504493
86surfactant homeostasis (GO:0043129)2.69433983
87tooth mineralization (GO:0034505)2.66873794
88negative regulation of T cell mediated immunity (GO:0002710)2.66734587
89purinergic nucleotide receptor signaling pathway (GO:0035590)2.66265414
90regulation of keratinocyte differentiation (GO:0045616)2.66073548
91fatty-acyl-CoA metabolic process (GO:0035337)2.65553069
92positive thymic T cell selection (GO:0045059)2.64204420
93epithelial cell differentiation (GO:0030855)2.63279501
94positive regulation of hair cycle (GO:0042635)2.62669166
95positive regulation of hair follicle development (GO:0051798)2.62669166
96defense response to Gram-negative bacterium (GO:0050829)2.62389673
97regulation of keratinocyte proliferation (GO:0010837)2.62271965
98regulation of cholesterol homeostasis (GO:2000188)2.61474215
99regulation of axon regeneration (GO:0048679)2.60530743
100regulation of neuron projection regeneration (GO:0070570)2.60530743
101regulation of protein localization to cell surface (GO:2000008)2.60275830
102phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.57784920
103phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.57417310
104negative regulation of cAMP-mediated signaling (GO:0043951)2.57024786
105regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56441816
106regulation of cardioblast differentiation (GO:0051890)2.55976873
107alditol phosphate metabolic process (GO:0052646)2.55346939
108planar cell polarity pathway involved in neural tube closure (GO:0090179)2.54781820
109cell-substrate junction assembly (GO:0007044)2.53621867
110long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.52895287
111positive regulation of meiotic cell cycle (GO:0051446)2.52570367
112regulation of interleukin-8 secretion (GO:2000482)2.52377372
113negative regulation of cardiac muscle hypertrophy (GO:0010614)2.49980553
114hair cell differentiation (GO:0035315)2.49709181
115negative regulation of cell fate commitment (GO:0010454)2.48596505
116regulation of monocyte chemotaxis (GO:0090025)2.48577345
117regulation of interleukin-17 production (GO:0032660)2.47881901
118negative regulation of acute inflammatory response (GO:0002674)2.47605750
119positive regulation of epidermal cell differentiation (GO:0045606)2.47526776
120phospholipid efflux (GO:0033700)2.45723591
121regulation of epidermis development (GO:0045682)2.44806116
122negative regulation of lipase activity (GO:0060192)2.44094762
123ventricular cardiac muscle cell action potential (GO:0086005)2.44041497
124sphingolipid biosynthetic process (GO:0030148)2.42070505
125dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.41705649
126regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.40804571
127positive regulation of cholesterol efflux (GO:0010875)2.40654890
128negative regulation of interferon-gamma production (GO:0032689)2.40347044
129regulation of cell proliferation involved in kidney development (GO:1901722)2.40117445
130eyelid development in camera-type eye (GO:0061029)2.38939274
131one-carbon compound transport (GO:0019755)2.38321635
132establishment of tissue polarity (GO:0007164)2.36563654
133establishment of planar polarity (GO:0001736)2.36563654
134negative regulation of interleukin-2 production (GO:0032703)2.36525219
135positive regulation of p38MAPK cascade (GO:1900745)2.36492182
136regulation of heart rate by cardiac conduction (GO:0086091)2.23734104
137regulation of epidermal cell differentiation (GO:0045604)2.23004863
138positive regulation of cellular amide metabolic process (GO:0034250)2.22997399
139polyol transport (GO:0015791)2.18279139
140unsaturated fatty acid biosynthetic process (GO:0006636)2.18092030
141regulation of cholesterol efflux (GO:0010874)2.10785915
142molting cycle process (GO:0022404)2.07075152
143hair cycle process (GO:0022405)2.07075152
144cell communication involved in cardiac conduction (GO:0086065)2.06285122
145negative regulation of lymphocyte differentiation (GO:0045620)2.05396415
146epithelial cell proliferation (GO:0050673)2.04477761
147establishment of skin barrier (GO:0061436)16.8570822
148regulation of water loss via skin (GO:0033561)14.6206905
149desmosome organization (GO:0002934)13.5527361
150hair cycle (GO:0042633)10.3075334
151molting cycle (GO:0042303)10.3075334
152phosphatidylglycerol metabolic process (GO:0046471)1.99545752

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.95442340
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.39743942
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.40842546
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.36514148
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.17075515
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.12000600
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.10557718
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02532381
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.00912032
10ZNF263_19887448_ChIP-Seq_K562_Human2.00102611
11TP63_17297297_ChIP-ChIP_HaCaT_Human14.3072589
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.95664770
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.93533630
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88902665
15SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88902665
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.63656269
17VDR_22108803_ChIP-Seq_LS180_Human1.56819588
18ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52297485
19* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.52065292
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51867510
21* TP63_23658742_ChIP-Seq_EP156T_Human1.51140270
22RXR_22108803_ChIP-Seq_LS180_Human1.47319117
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45314869
24CTCF_27219007_Chip-Seq_Bcells_Human1.45090960
25ATF3_27146783_Chip-Seq_COLON_Human1.44618780
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40978124
27TP63_22573176_ChIP-Seq_HFKS_Human1.40862648
28* GATA6_21074721_ChIP-Seq_CACO-2_Human1.35715753
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.34911366
30KLF5_25053715_ChIP-Seq_YYC3_Human1.34017876
31SOX2_20726797_ChIP-Seq_SW620_Human1.33758047
32RACK7_27058665_Chip-Seq_MCF-7_Human1.27187681
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26158791
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25774510
35GATA3_24758297_ChIP-Seq_MCF-7_Human1.24984874
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24879992
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21690810
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20777447
39CJUN_26792858_Chip-Seq_BT549_Human1.20751602
40BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19328040
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17674664
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17171731
43CEBPB_22108803_ChIP-Seq_LS180_Human1.16672058
44BCAT_22108803_ChIP-Seq_LS180_Human1.15928704
45AR_21572438_ChIP-Seq_LNCaP_Human1.14980324
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14737829
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12606832
48ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12087933
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11511186
50* ERG_20517297_ChIP-Seq_VCAP_Human1.11265262
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09594021
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08434200
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.08010761
54* CTCF_20526341_ChIP-Seq_ESCs_Human1.07864481
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07574849
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06993895
57LXR_22292898_ChIP-Seq_THP-1_Human1.06156709
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.05601297
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04802602
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.01304713
61TP53_18474530_ChIP-ChIP_U2OS_Human1.00822340
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00515346
63AHR_22903824_ChIP-Seq_MCF-7_Human0.99858966
64BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99430237
65UBF1/2_26484160_Chip-Seq_HMECs_Human0.99158259
66JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98502939
67P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98098999
68EGR1_19032775_ChIP-ChIP_M12_Human0.97077884
69CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97057933
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96584131
71GATA3_21867929_ChIP-Seq_TH1_Mouse0.94061717
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93747145
73NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93747145
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93414100
75* BCOR_27268052_Chip-Seq_Bcells_Human0.92691978
76GATA4_25053715_ChIP-Seq_YYC3_Human0.92504877
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91765989
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90542116
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89383820
80TCF4_22108803_ChIP-Seq_LS180_Human0.88585871
81* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.87829810
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.86612893
83EZH2_27304074_Chip-Seq_ESCs_Mouse0.86214779
84GATA6_25053715_ChIP-Seq_YYC3_Human0.86018165
85P53_21459846_ChIP-Seq_SAOS-2_Human0.85848510
86PIAS1_25552417_ChIP-Seq_VCAP_Human0.85447946
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.85303569
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.83990981
89JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83867592
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.83725810
91YY1_22570637_ChIP-Seq_MALME-3M_Human0.82323935
92CLOCK_20551151_ChIP-Seq_293T_Human0.81900998
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81373813
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.80478890
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80289951
96HTT_18923047_ChIP-ChIP_STHdh_Human0.79541972
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.79130886
98HNFA_21074721_ChIP-Seq_CACO-2_Human0.78681856
99OCT1_27270436_Chip-Seq_PROSTATE_Human0.78111949
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77615820
101MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.77402566
102RBPJ_21746931_ChIP-Seq_IB4_Human0.76074855
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75520427
104SMAD4_21799915_ChIP-Seq_A2780_Human0.75448311
105ERG_21242973_ChIP-ChIP_JURKAT_Human0.74524842
106AR_25329375_ChIP-Seq_VCAP_Human0.74258014
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73672400
108RNF2_27304074_Chip-Seq_ESCs_Mouse0.73449910
109NANOG_20526341_ChIP-Seq_ESCs_Human0.73175931
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.72916813
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72913930
112STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.72414888
113E2F1_20622854_ChIP-Seq_HELA_Human0.72001774
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.71705115
115BCL6_27268052_Chip-Seq_Bcells_Human0.71646273
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.71410340
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70888012
118* TAF2_19829295_ChIP-Seq_ESCs_Human0.70676658
119SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70636243
120SMC4_20622854_ChIP-Seq_HELA_Human0.70571024
121CSB_26484114_Chip-Seq_FIBROBLAST_Human0.70011594
122GATA2_21666600_ChIP-Seq_HMVEC_Human0.69988736
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.69838947
124CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69786992
125CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.69759647
126CDX2_22108803_ChIP-Seq_LS180_Human0.69616401
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69509228
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.69059468
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68205310
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.68187178
131SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.68118347
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68034052
133SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.67885977
134TP53_16413492_ChIP-PET_HCT116_Human0.67518294
135GATA2_19941826_ChIP-Seq_K562_Human0.66340888
136SMAD4_21741376_ChIP-Seq_ESCs_Human0.66195800
137GATA1_22025678_ChIP-Seq_K562_Human0.65851582
138NCOR_22424771_ChIP-Seq_293T_Human0.65791996
139TBX20_22328084_ChIP-Seq_HEART_Mouse0.65427415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.82469147
2MP0005275_abnormal_skin_tensile7.34717939
3MP0005501_abnormal_skin_physiology5.37972240
4MP0010234_abnormal_vibrissa_follicle4.33478799
5MP0000579_abnormal_nail_morphology4.17844301
6MP0003941_abnormal_skin_development3.69485075
7MP0002060_abnormal_skin_morphology3.65300309
8MP0004381_abnormal_hair_follicle3.54500456
9MP0001216_abnormal_epidermal_layer3.49860852
10MP0004947_skin_inflammation3.40435380
11MP0010771_integument_phenotype3.27577369
12MP0000647_abnormal_sebaceous_gland3.11226563
13MP0002098_abnormal_vibrissa_morphology3.08165248
14MP0002254_reproductive_system_inflammat3.03310687
15MP0003705_abnormal_hypodermis_morpholog2.90678288
16MP0005451_abnormal_body_composition2.79678613
17MP0000383_abnormal_hair_follicle2.59964107
18MP0003453_abnormal_keratinocyte_physiol2.57220511
19MP0010678_abnormal_skin_adnexa2.43911834
20MP0004885_abnormal_endolymph2.40693343
21MP0005377_hearing/vestibular/ear_phenot2.30353645
22MP0003878_abnormal_ear_physiology2.30353645
23MP0000377_abnormal_hair_follicle2.29598443
24MP0000467_abnormal_esophagus_morphology2.25753492
25MP0002009_preneoplasia2.10764316
26MP0000427_abnormal_hair_cycle2.04599066
27MP0001188_hyperpigmentation1.90819843
28MP0009931_abnormal_skin_appearance1.90382074
29MP0001243_abnormal_dermal_layer1.85864661
30MP0000762_abnormal_tongue_morphology1.65039437
31MP0001191_abnormal_skin_condition1.63924230
32MP0001851_eye_inflammation1.58837794
33MP0001346_abnormal_lacrimal_gland1.55763529
34MP0000367_abnormal_coat/_hair1.55307154
35MP0003566_abnormal_cell_adhesion1.41189360
36MP0004185_abnormal_adipocyte_glucose1.32691022
37MP0003191_abnormal_cellular_cholesterol1.12936440
38MP0002006_tumorigenesis1.07767470
39MP0002234_abnormal_pharynx_morphology1.05829860
40MP0000566_synostosis1.04655442
41MP0002877_abnormal_melanocyte_morpholog0.97116043
42MP0001340_abnormal_eyelid_morphology0.92664099
43MP0002166_altered_tumor_susceptibility0.91347030
44MP0003011_delayed_dark_adaptation0.86773907
45MP0002163_abnormal_gland_morphology0.85456281
46MP0003763_abnormal_thymus_physiology0.82134234
47MP0003136_yellow_coat_color0.81909421
48MP0000750_abnormal_muscle_regeneration0.80017412
49MP0003315_abnormal_perineum_morphology0.75498683
50MP0002095_abnormal_skin_pigmentation0.74972497
51MP0000015_abnormal_ear_pigmentation0.72715126
52MP0000465_gastrointestinal_hemorrhage0.69577706
53MP0005174_abnormal_tail_pigmentation0.69536035
54MP0001784_abnormal_fluid_regulation0.66958254
55MP0005023_abnormal_wound_healing0.66095578
56MP0002138_abnormal_hepatobiliary_system0.64775285
57MP0009053_abnormal_anal_canal0.64249955
58MP0002177_abnormal_outer_ear0.60958486
59MP0005503_abnormal_tendon_morphology0.59198535
60MP0004782_abnormal_surfactant_physiolog0.57104375
61MP0000627_abnormal_mammary_gland0.55372631
62MP0005409_darkened_coat_color0.55009927
63MP0004043_abnormal_pH_regulation0.54351821
64MP0009379_abnormal_foot_pigmentation0.54122640
65MP0001849_ear_inflammation0.51723357
66MP0008438_abnormal_cutaneous_collagen0.50485282
67MP0003755_abnormal_palate_morphology0.49440349
68MP0010030_abnormal_orbit_morphology0.47134681
69MP0003300_gastrointestinal_ulcer0.46898382
70MP0009780_abnormal_chondrocyte_physiolo0.46246854
71MP0005076_abnormal_cell_differentiation0.44354506
72MP0010352_gastrointestinal_tract_polyps0.41924976
73MP0000537_abnormal_urethra_morphology0.40317728
74MP0009333_abnormal_splenocyte_physiolog0.38147564
75MP0005666_abnormal_adipose_tissue0.36919305
76MP0001177_atelectasis0.35062719
77MP0005379_endocrine/exocrine_gland_phen0.34469715
78MP0003448_altered_tumor_morphology0.33172802
79MP0004197_abnormal_fetal_growth/weight/0.32926163
80MP0005187_abnormal_penis_morphology0.32777435
81MP0000372_irregular_coat_pigmentation0.30062366
82MP0002111_abnormal_tail_morphology0.29577270
83MP0002133_abnormal_respiratory_system0.29221705
84MP0005388_respiratory_system_phenotype0.29221705
85MP0001485_abnormal_pinna_reflex0.28872996
86MP0000470_abnormal_stomach_morphology0.28216781
87MP0008789_abnormal_olfactory_epithelium0.28210721
88MP0002148_abnormal_hypersensitivity_rea0.28015492
89MP0000613_abnormal_salivary_gland0.27709777
90MP0003329_amyloid_beta_deposits0.27011049
91MP0009672_abnormal_birth_weight0.27009037
92MP0004264_abnormal_extraembryonic_tissu0.26090409
93MP0003950_abnormal_plasma_membrane0.24736473
94MP0000538_abnormal_urinary_bladder0.24572737
95MP0004019_abnormal_vitamin_homeostasis0.24386838
96MP0005075_abnormal_melanosome_morpholog0.23190935
97MP0000432_abnormal_head_morphology0.22750665
98MP0000751_myopathy0.22669479
99MP0002090_abnormal_vision0.22314827
100MP0002233_abnormal_nose_morphology0.21705750
101MP0000569_abnormal_digit_pigmentation0.21700258
102MP0009384_cardiac_valve_regurgitation0.21403865
103MP0005508_abnormal_skeleton_morphology0.21169633
104MP0005394_taste/olfaction_phenotype0.21146676
105MP0005499_abnormal_olfactory_system0.21146676
106MP0002282_abnormal_trachea_morphology0.20267257
107MP0002971_abnormal_brown_adipose0.20258005
108MP0001348_abnormal_lacrimal_gland0.20138422
109MP0008004_abnormal_stomach_pH0.20109113
110MP0001984_abnormal_olfaction0.18611713
111MP0005375_adipose_tissue_phenotype0.18608279
112MP0008961_abnormal_basal_metabolism0.18599890
113MP0000759_abnormal_skeletal_muscle0.18468672
114MP0004087_abnormal_muscle_fiber0.18436169
115MP0003828_pulmonary_edema0.18199406
116MP0002249_abnormal_larynx_morphology0.17270544
117MP0000428_abnormal_craniofacial_morphol0.16325823
118MP0000003_abnormal_adipose_tissue0.16105566
119MP0005620_abnormal_muscle_contractility0.15645643
120MP0001853_heart_inflammation0.15471610
121MP0004272_abnormal_basement_membrane0.15317139
122MP0002106_abnormal_muscle_physiology0.14820820
123MP0002697_abnormal_eye_size0.14716640
124MP0003638_abnormal_response/metabolism_0.14671845
125MP0009115_abnormal_fat_cell0.14515745
126MP0001186_pigmentation_phenotype0.13690125
127MP0005193_abnormal_anterior_eye0.13174456
128MP0001502_abnormal_circadian_rhythm0.09840850
129MP0006138_congestive_heart_failure0.08787404
130MP0008569_lethality_at_weaning0.08012899
131MP0001756_abnormal_urination0.07663302
132MP0000685_abnormal_immune_system0.06790520

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.30496537
2Hypotrichosis (HP:0001006)8.23479187
3Conjunctival hamartoma (HP:0100780)7.32195666
4Palmoplantar hyperkeratosis (HP:0000972)7.27105663
5Plantar hyperkeratosis (HP:0007556)6.96795373
6Abnormality of nail color (HP:0100643)6.91485885
7Palmar hyperkeratosis (HP:0010765)6.84834852
8Erythema (HP:0010783)6.43988416
9Erythroderma (HP:0001019)6.28699448
10Woolly hair (HP:0002224)6.28057327
11Congenital ichthyosiform erythroderma (HP:0007431)6.00567417
12Onycholysis (HP:0001806)5.91903291
13Right ventricular cardiomyopathy (HP:0011663)5.83457813
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.35054442
15Thick nail (HP:0001805)5.04866387
16Fragile nails (HP:0001808)4.87092499
17Gangrene (HP:0100758)4.81094809
18Pili torti (HP:0003777)4.77136645
19Hamartoma of the eye (HP:0010568)4.52845380
20Abnormal blistering of the skin (HP:0008066)4.42477259
21Milia (HP:0001056)3.91622243
22Autoimmune hemolytic anemia (HP:0001890)3.77547372
23Absent eyelashes (HP:0000561)3.76031642
24Corneal erosion (HP:0200020)3.73846960
25Parakeratosis (HP:0001036)3.67392198
26Nail dystrophy (HP:0008404)3.62450576
27Pustule (HP:0200039)3.60383677
28Palmoplantar keratoderma (HP:0000982)3.54194345
29Hypohidrosis (HP:0000966)3.42776226
30Absent hair (HP:0002298)3.39233426
31Ectropion (HP:0000656)3.37503869
32Lip pit (HP:0100267)3.37285663
33Hyporeflexia of lower limbs (HP:0002600)3.36697895
34Sparse eyelashes (HP:0000653)3.22172494
35Areflexia of lower limbs (HP:0002522)3.20850945
36Ventricular tachycardia (HP:0004756)3.17394394
37Alopecia of scalp (HP:0002293)3.16567621
38Curly hair (HP:0002212)3.14571242
39Pruritus (HP:0000989)3.04354089
40Abnormal hair laboratory examination (HP:0003328)3.02398746
41Hypergammaglobulinemia (HP:0010702)2.99256599
42Furrowed tongue (HP:0000221)2.86566119
43Oral leukoplakia (HP:0002745)2.82653266
44Ridged nail (HP:0001807)2.73829097
45Eczematoid dermatitis (HP:0000976)2.65902340
46Distal lower limb muscle weakness (HP:0009053)2.65501470
47Advanced eruption of teeth (HP:0006288)2.62483104
48Achilles tendon contracture (HP:0001771)2.52695812
49Follicular hyperkeratosis (HP:0007502)2.51057362
50Autoamputation (HP:0001218)2.47292004
51Round ear (HP:0100830)2.43330680
52Stomatitis (HP:0010280)2.42604192
53Abnormality of placental membranes (HP:0011409)2.41577743
54Amniotic constriction ring (HP:0009775)2.41577743
55Natal tooth (HP:0000695)2.41357087
56Concave nail (HP:0001598)2.37771752
57Increased connective tissue (HP:0009025)2.36344819
58Brittle hair (HP:0002299)2.34151437
59Atrophic scars (HP:0001075)2.33733850
60Abnormality of the Achilles tendon (HP:0005109)2.33358485
61Abnormality of the axillary hair (HP:0100134)2.33306819
62Abnormality of secondary sexual hair (HP:0009888)2.33306819
63Oligodontia (HP:0000677)2.31988286
64Acanthosis nigricans (HP:0000956)2.29126089
65Type 1 muscle fiber predominance (HP:0003803)2.28653550
66Slow-growing hair (HP:0002217)2.28617145
67Abnormality of hair growth rate (HP:0011363)2.28617145
68Selective tooth agenesis (HP:0001592)2.24469291
69Abnormality of the labia majora (HP:0012881)2.22064968
70Split foot (HP:0001839)2.14336259
71Muscle fiber inclusion bodies (HP:0100299)2.11556579
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.11224552
73Lack of skin elasticity (HP:0100679)2.10488500
74Distal arthrogryposis (HP:0005684)2.09044036
75Fatigable weakness (HP:0003473)2.08951165
76Abnormality of the neuromuscular junction (HP:0003398)2.08951165
77Nemaline bodies (HP:0003798)2.04050966
78Urticaria (HP:0001025)2.03747503
79Hamartoma (HP:0010566)2.01495742
80Sparse scalp hair (HP:0002209)2.01377011
81Hyperhidrosis (HP:0000975)1.99860464
82Abnormal pupillary function (HP:0007686)1.93974100
83Depressed nasal tip (HP:0000437)1.93434747
84Paralysis (HP:0003470)1.93335007
85Aplasia cutis congenita (HP:0001057)1.88000312
86Blepharitis (HP:0000498)1.85966504
87Melanocytic nevus (HP:0000995)1.83880563
88Muscle fiber splitting (HP:0003555)1.82266639
89Recurrent corneal erosions (HP:0000495)1.82106307
90Congenital, generalized hypertrichosis (HP:0004540)1.81337768
91Multifactorial inheritance (HP:0001426)1.80829619
92Exercise-induced myalgia (HP:0003738)1.79829669
93Verrucae (HP:0200043)1.79231764
94Papilloma (HP:0012740)1.79231764
95Abnormality of the salivary glands (HP:0010286)1.78381616
96Malignant hyperthermia (HP:0002047)1.78376382
97Myopathic facies (HP:0002058)1.77897309
98Septate vagina (HP:0001153)1.77395427
99Fine hair (HP:0002213)1.76477602
100Sudden death (HP:0001699)1.76381612
101Abnormality of the gastric mucosa (HP:0004295)1.76129397
102Abnormality of the dental root (HP:0006486)1.75289590
103Taurodontia (HP:0000679)1.75289590
104Abnormality of permanent molar morphology (HP:0011071)1.75289590
105Sepsis (HP:0100806)1.72364491
106Skin ulcer (HP:0200042)1.72321797
107Nasolacrimal duct obstruction (HP:0000579)1.69763276
108Popliteal pterygium (HP:0009756)1.69044538
109Ventricular fibrillation (HP:0001663)1.68463215
110Corneal dystrophy (HP:0001131)1.67321242
111Neck muscle weakness (HP:0000467)1.66798140
112Duplicated collecting system (HP:0000081)1.66717779
113Abnormality of molar morphology (HP:0011070)1.65813941
114Abnormality of molar (HP:0011077)1.65813941
115Xerostomia (HP:0000217)1.63707641
116Calcaneovalgus deformity (HP:0001848)1.63195865
117Dry skin (HP:0000958)1.63018161
118Ulnar deviation of the wrist (HP:0003049)1.59717846
119Anhidrosis (HP:0000970)1.58049632
120Abnormality of the dental pulp (HP:0006479)1.56713010
121Anonychia (HP:0001798)1.56537146
122Dehydration (HP:0001944)1.56086333
123Fragile skin (HP:0001030)1.55384455
124Labial hypoplasia (HP:0000066)1.53685738
125Keratoconjunctivitis sicca (HP:0001097)1.52562463
126Amelogenesis imperfecta (HP:0000705)1.52447822
127Conical tooth (HP:0000698)1.51671807
128Hypoplastic labia majora (HP:0000059)1.51248228
129Carious teeth (HP:0000670)1.48751484
130Abnormality of the distal phalanges of the toes (HP:0010182)1.48645507
131Dry hair (HP:0011359)1.48564493
132Laryngomalacia (HP:0001601)1.47147020
133Difficulty running (HP:0009046)1.45747603
134Abnormality of the renal collecting system (HP:0004742)1.41697539
135Abnormality of small intestinal villus morphology (HP:0011472)1.41585964
136Villous atrophy (HP:0011473)1.41585964
137Hypoplastic female external genitalia (HP:0012815)1.39420388
138Abnormality of the fingernails (HP:0001231)1.36868597

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.03298481
2MAPKAPK35.18692724
3FER4.54934877
4MAP3K34.11762798
5RIPK13.56923314
6MST43.27353865
7BCR3.18227259
8MST1R2.94018792
9BRD42.75548758
10SGK2232.50208106
11SGK4942.50208106
12TTN2.44336917
13RPS6KB22.37685649
14TAOK12.30271923
15ERN12.16333231
16PIK3CG2.14240919
17MAP3K22.13560692
18WNK12.09754624
19DYRK1B2.06263136
20EEF2K2.05595468
21FGFR11.98134571
22EPHB21.95888966
23MAP3K111.78555078
24MAP2K31.72047832
25EPHA21.57902934
26OBSCN1.56184454
27SGK21.56034940
28CDK61.53814018
29TRPM71.51508501
30DAPK21.50398551
31IRAK11.50013551
32MAPKAPK51.42996301
33LRRK21.31164996
34SGK31.28761130
35AKT31.28128559
36STK31.27490851
37CAMK1D1.18100828
38MAP2K61.14231804
39CDK121.12002990
40MAP3K71.08312746
41GRK61.07019214
42IKBKB1.06919921
43MARK21.05126888
44CAMK1G1.02229579
45CDK41.01463918
46LATS10.99597867
47ITK0.97096879
48TNK20.96044131
49MAP3K140.94385581
50NLK0.94094715
51NTRK20.92605014
52MAPKAPK20.92284785
53EPHA30.91674185
54FGFR20.89599334
55MAP3K10.87376187
56DYRK30.86418780
57FRK0.84902038
58IRAK20.84549741
59PTK60.82391631
60PIM20.81148260
61MAP3K90.79998938
62FGFR40.78954990
63STK100.77303758
64PDGFRB0.75002028
65MET0.73400796
66GSK3A0.71124251
67EPHB10.68169172
68TIE10.67582151
69STK38L0.67223186
70TESK10.66752013
71TAOK30.66643705
72TBK10.66139651
73HCK0.65928145
74SGK10.65297929
75PDGFRA0.64841938
76MTOR0.64377267
77ADRBK10.64028205
78PRKAA20.61556470
79ERBB30.60895865
80DDR20.60615091
81PAK30.60399904
82TRIB30.60232210
83TAOK20.59824049
84DMPK0.58356332
85PRKCE0.57683492
86BMX0.55906855
87RIPK40.55868042
88FGFR30.55310288
89IRAK40.54988129
90BLK0.54731836
91STK380.52620717
92NME10.51826250
93PRKCI0.51482149
94CAMK2G0.50880115
95PHKG20.50595671
96PHKG10.50595671
97TYK20.42701341
98PKN10.41592970
99FYN0.41505917
100KIT0.41338271
101PRKD10.40851668
102AURKA0.40638935
103LIMK10.40409384
104RPS6KB10.39546131
105LATS20.39406650
106DYRK20.39137410
107SIK30.38661699
108STK240.38124157
109CDK90.36795259
110IKBKE0.35833984
111CAMK2D0.35572110
112TGFBR20.34138852
113KSR20.33875390
114CHUK0.33655776
115FLT30.33323966
116MAP2K40.33215183
117PTK20.33215043
118ABL10.33073536
119TXK0.32400620
120TYRO30.31304734
121CDC42BPA0.30494780
122MAPK120.30329867
123MOS0.30259266
124ERBB40.29359242
125RET0.29001946
126HIPK20.28138882
127ROCK10.27472938
128MAPK90.26964597
129TAF10.26570537
130CSK0.26553832
131MAP2K10.26509138
132ROCK20.25057888
133SRC0.23720302
134ICK0.23717109
135MINK10.23036016
136MAP3K60.22568987
137PRKD20.22510847
138MAP3K50.22037107
139ABL20.21882961
140STK390.21837200
141GRK70.21761781
142MAP4K10.21481712
143GRK10.21272136
144FGR0.20570645
145MAP3K120.20471640
146MAPK70.19780425
147PRKACA0.19773295
148RPS6KA10.19601015
149AURKB0.18789843
150IGF1R0.18747435
151PRKCA0.18485483

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.22774403
2Linoleic acid metabolism_Homo sapiens_hsa005913.21123689
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.16580756
4Fatty acid elongation_Homo sapiens_hsa000622.67894713
5Arachidonic acid metabolism_Homo sapiens_hsa005902.44883922
6Circadian rhythm_Homo sapiens_hsa047102.42075600
7Sphingolipid metabolism_Homo sapiens_hsa006002.24966181
8Bladder cancer_Homo sapiens_hsa052192.11175488
9Phenylalanine metabolism_Homo sapiens_hsa003602.10678940
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09066439
11Sulfur metabolism_Homo sapiens_hsa009202.00081986
12Ether lipid metabolism_Homo sapiens_hsa005651.92925866
13Histidine metabolism_Homo sapiens_hsa003401.89763061
14Staphylococcus aureus infection_Homo sapiens_hsa051501.87780868
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74698167
16Renin secretion_Homo sapiens_hsa049241.61318146
17Fat digestion and absorption_Homo sapiens_hsa049751.55955169
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54148818
19Retinol metabolism_Homo sapiens_hsa008301.51531019
20Dorso-ventral axis formation_Homo sapiens_hsa043201.43457120
21Steroid biosynthesis_Homo sapiens_hsa001001.41288857
22Choline metabolism in cancer_Homo sapiens_hsa052311.36087033
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.35661717
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32902361
25VEGF signaling pathway_Homo sapiens_hsa043701.28438095
26GnRH signaling pathway_Homo sapiens_hsa049121.24233928
27Ribosome_Homo sapiens_hsa030101.23557288
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23017073
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.22341688
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22335939
31Olfactory transduction_Homo sapiens_hsa047401.21442680
32Non-small cell lung cancer_Homo sapiens_hsa052231.20674898
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17720999
34Adherens junction_Homo sapiens_hsa045201.15992821
35Tight junction_Homo sapiens_hsa045301.15604634
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11252031
37Tyrosine metabolism_Homo sapiens_hsa003501.04618210
38Phototransduction_Homo sapiens_hsa047440.99033979
39Platelet activation_Homo sapiens_hsa046110.96225479
40Axon guidance_Homo sapiens_hsa043600.95672919
41Chemical carcinogenesis_Homo sapiens_hsa052040.95033051
42Gastric acid secretion_Homo sapiens_hsa049710.93569285
43Proteoglycans in cancer_Homo sapiens_hsa052050.93347904
44Long-term depression_Homo sapiens_hsa047300.92636058
45ECM-receptor interaction_Homo sapiens_hsa045120.89701024
46Oxytocin signaling pathway_Homo sapiens_hsa049210.89386897
47Leukocyte transendothelial migration_Homo sapiens_hsa046700.88256020
48Basal cell carcinoma_Homo sapiens_hsa052170.86632080
49Ras signaling pathway_Homo sapiens_hsa040140.85849258
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85422579
51Sphingolipid signaling pathway_Homo sapiens_hsa040710.85225706
52T cell receptor signaling pathway_Homo sapiens_hsa046600.85216994
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84875661
54ABC transporters_Homo sapiens_hsa020100.84088691
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.83755986
56Melanogenesis_Homo sapiens_hsa049160.82927677
57Hippo signaling pathway_Homo sapiens_hsa043900.81985856
58Fatty acid biosynthesis_Homo sapiens_hsa000610.81501152
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80897713
60Primary immunodeficiency_Homo sapiens_hsa053400.80819322
61Pancreatic secretion_Homo sapiens_hsa049720.79238690
62Serotonergic synapse_Homo sapiens_hsa047260.76771932
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.74986639
64Pertussis_Homo sapiens_hsa051330.74726459
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74429060
66Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73163602
67Amoebiasis_Homo sapiens_hsa051460.73011615
68Glutamatergic synapse_Homo sapiens_hsa047240.69267157
69Tuberculosis_Homo sapiens_hsa051520.68231320
70Glioma_Homo sapiens_hsa052140.66359285
71Salivary secretion_Homo sapiens_hsa049700.65387134
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.65025648
73PPAR signaling pathway_Homo sapiens_hsa033200.64437658
74Renal cell carcinoma_Homo sapiens_hsa052110.63478089
75Calcium signaling pathway_Homo sapiens_hsa040200.63350330
76Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63147686
77MicroRNAs in cancer_Homo sapiens_hsa052060.63113768
78Toxoplasmosis_Homo sapiens_hsa051450.62036215
79Hepatitis C_Homo sapiens_hsa051600.60514928
80Notch signaling pathway_Homo sapiens_hsa043300.59520708
81ErbB signaling pathway_Homo sapiens_hsa040120.59269259
82Long-term potentiation_Homo sapiens_hsa047200.59157295
83MAPK signaling pathway_Homo sapiens_hsa040100.58849274
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57569754
85Graft-versus-host disease_Homo sapiens_hsa053320.57221190
86Inositol phosphate metabolism_Homo sapiens_hsa005620.56368749
87p53 signaling pathway_Homo sapiens_hsa041150.56356671
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.56196203
89Dilated cardiomyopathy_Homo sapiens_hsa054140.55844642
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55794027
91Hematopoietic cell lineage_Homo sapiens_hsa046400.55572158
92Endocytosis_Homo sapiens_hsa041440.55384238
93Insulin resistance_Homo sapiens_hsa049310.53936853
94Insulin signaling pathway_Homo sapiens_hsa049100.52941125
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51908564
96Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50904423
97beta-Alanine metabolism_Homo sapiens_hsa004100.50741777
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50354298
99Acute myeloid leukemia_Homo sapiens_hsa052210.49424165
100Small cell lung cancer_Homo sapiens_hsa052220.49243745
101Collecting duct acid secretion_Homo sapiens_hsa049660.49039394
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48603461
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45907933
104Glucagon signaling pathway_Homo sapiens_hsa049220.45243892
105Caffeine metabolism_Homo sapiens_hsa002320.45232701
106Arginine biosynthesis_Homo sapiens_hsa002200.45133069
107cAMP signaling pathway_Homo sapiens_hsa040240.43916554
108Steroid hormone biosynthesis_Homo sapiens_hsa001400.42829593
109Protein digestion and absorption_Homo sapiens_hsa049740.41496160
110Rap1 signaling pathway_Homo sapiens_hsa040150.41295016
111Estrogen signaling pathway_Homo sapiens_hsa049150.39994015
112Osteoclast differentiation_Homo sapiens_hsa043800.38781174
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37896298
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37836203
115Fatty acid degradation_Homo sapiens_hsa000710.36761171
116Thyroid cancer_Homo sapiens_hsa052160.36551121
117Circadian entrainment_Homo sapiens_hsa047130.36242661
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36205540
119Hedgehog signaling pathway_Homo sapiens_hsa043400.36147259
120Ovarian steroidogenesis_Homo sapiens_hsa049130.35762758
121TGF-beta signaling pathway_Homo sapiens_hsa043500.35694182
122Salmonella infection_Homo sapiens_hsa051320.35673026
123Wnt signaling pathway_Homo sapiens_hsa043100.35378869
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34956428
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.33850411
126Pancreatic cancer_Homo sapiens_hsa052120.33540651
127Amphetamine addiction_Homo sapiens_hsa050310.33224409
128Influenza A_Homo sapiens_hsa051640.33183091
129Mineral absorption_Homo sapiens_hsa049780.32099323
130Pathways in cancer_Homo sapiens_hsa052000.31755631
131FoxO signaling pathway_Homo sapiens_hsa040680.31152305
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29261064
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27956281
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27038941

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