KPTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a filamentous-actin-associated protein, which is involved in actin dynamics and plays an important role in neuromorphogenesis. Mutations in this gene result in recessive mental retardation-41. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic metaphase/anaphase transition (GO:0045842)5.49824197
2positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)5.49824197
3positive regulation of mitotic sister chromatid separation (GO:1901970)5.49824197
4negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.08507362
5positive regulation of chromosome segregation (GO:0051984)4.86926686
6regulation of sister chromatid cohesion (GO:0007063)4.84469761
7prenylation (GO:0097354)4.77522271
8protein prenylation (GO:0018342)4.77522271
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70960264
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.67773506
11maturation of SSU-rRNA (GO:0030490)4.67437618
12chaperone-mediated protein transport (GO:0072321)4.66653543
13transcription elongation from RNA polymerase III promoter (GO:0006385)4.59911620
14termination of RNA polymerase III transcription (GO:0006386)4.59911620
15ribosomal small subunit assembly (GO:0000028)4.46584767
16ATP synthesis coupled proton transport (GO:0015986)4.46307951
17energy coupled proton transport, down electrochemical gradient (GO:0015985)4.46307951
18DNA deamination (GO:0045006)4.42962414
19oxidative phosphorylation (GO:0006119)4.34590336
20autophagic vacuole fusion (GO:0000046)4.30137249
21regulation of retinoic acid receptor signaling pathway (GO:0048385)4.24412835
22negative regulation of Ras GTPase activity (GO:0034261)4.14151451
23amino acid salvage (GO:0043102)4.11109274
24L-methionine salvage (GO:0071267)4.11109274
25L-methionine biosynthetic process (GO:0071265)4.11109274
26NADH metabolic process (GO:0006734)4.10937968
27L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.04758247
28pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.92589332
29deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.91189663
30coenzyme A biosynthetic process (GO:0015937)3.83489653
31telomere maintenance via recombination (GO:0000722)3.81908315
32pyrimidine nucleotide catabolic process (GO:0006244)3.80776183
33mitochondrial RNA metabolic process (GO:0000959)3.76897436
34tricarboxylic acid cycle (GO:0006099)3.76632252
35purine nucleobase biosynthetic process (GO:0009113)3.75662991
36oxaloacetate metabolic process (GO:0006107)3.71539349
37transcription-coupled nucleotide-excision repair (GO:0006283)3.71062153
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.69396697
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.69396697
40NADH dehydrogenase complex assembly (GO:0010257)3.69396697
41mitotic recombination (GO:0006312)3.62694646
42vesicle fusion (GO:0006906)3.61737962
43peptidyl-lysine dimethylation (GO:0018027)3.55653872
44base-excision repair, AP site formation (GO:0006285)3.52512184
45viral transcription (GO:0019083)3.44626336
46S-adenosylmethionine metabolic process (GO:0046500)3.43807482
47translational elongation (GO:0006414)3.40167372
48metallo-sulfur cluster assembly (GO:0031163)3.37467700
49iron-sulfur cluster assembly (GO:0016226)3.37467700
50kinetochore assembly (GO:0051382)3.37460388
51translational termination (GO:0006415)3.36102190
52proteasome assembly (GO:0043248)3.35634035
53electron transport chain (GO:0022900)3.33239152
54glycine metabolic process (GO:0006544)3.33194887
55regulation of mitochondrial translation (GO:0070129)3.31817053
56respiratory electron transport chain (GO:0022904)3.31045275
57protein complex biogenesis (GO:0070271)3.28775883
58L-phenylalanine metabolic process (GO:0006558)3.28657599
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28657599
60protein targeting to mitochondrion (GO:0006626)3.28505481
61nucleobase biosynthetic process (GO:0046112)3.25514922
62deoxyribonucleotide catabolic process (GO:0009264)3.24024149
637-methylguanosine mRNA capping (GO:0006370)3.23337512
64succinate metabolic process (GO:0006105)3.22893498
65establishment of viral latency (GO:0019043)3.22717534
66pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.21934612
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.21612842
68establishment of protein localization to mitochondrial membrane (GO:0090151)3.21520005
69mitochondrial respiratory chain complex assembly (GO:0033108)3.21277738
70establishment of protein localization to mitochondrion (GO:0072655)3.16706482
71GDP-mannose metabolic process (GO:0019673)3.15199441
72RNA capping (GO:0036260)3.13056668
737-methylguanosine RNA capping (GO:0009452)3.13056668
74double-strand break repair via nonhomologous end joining (GO:0006303)3.12917803
75non-recombinational repair (GO:0000726)3.12917803
76cellular metabolic compound salvage (GO:0043094)3.11850648
77pseudouridine synthesis (GO:0001522)3.11693358
78negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.11221512
79organelle membrane fusion (GO:0090174)3.08766238
80pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08559199
81telomere maintenance via semi-conservative replication (GO:0032201)3.08442092
82DNA strand elongation involved in DNA replication (GO:0006271)3.08094814
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05571470
84sulfur amino acid biosynthetic process (GO:0000097)3.05541583
85negative regulation of T cell receptor signaling pathway (GO:0050860)3.04799719
86cysteine metabolic process (GO:0006534)3.04605050
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04313877
88nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.03567556
89spliceosomal snRNP assembly (GO:0000387)3.02514169
90deoxyribose phosphate catabolic process (GO:0046386)3.02149576
912-oxoglutarate metabolic process (GO:0006103)3.02129385
92regulation of cellular amino acid metabolic process (GO:0006521)3.02012698
93DNA strand elongation (GO:0022616)3.00790947
94tRNA modification (GO:0006400)3.00685275
95chromatin remodeling at centromere (GO:0031055)2.95549079
96L-phenylalanine catabolic process (GO:0006559)2.95212555
97erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.95212555
983-UTR-mediated mRNA stabilization (GO:0070935)2.95096073
99cytochrome complex assembly (GO:0017004)2.94185609
100hexose biosynthetic process (GO:0019319)2.94132165
101UTP biosynthetic process (GO:0006228)2.93947564
102formation of translation preinitiation complex (GO:0001731)2.93690752
103negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.92844983
104galactose catabolic process (GO:0019388)2.92692102
105GTP biosynthetic process (GO:0006183)2.91815444
106nucleoside diphosphate biosynthetic process (GO:0009133)2.88421337
107regulation of cellular respiration (GO:0043457)2.88276535
108glyoxylate metabolic process (GO:0046487)2.88053809
109establishment of integrated proviral latency (GO:0075713)2.87244243
110histone arginine methylation (GO:0034969)2.86829887
111negative regulation of circadian rhythm (GO:0042754)2.84959924
112organelle fusion (GO:0048284)2.84913605
113establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84636830
114protein localization to mitochondrion (GO:0070585)2.84436095
115protein localization to endoplasmic reticulum (GO:0070972)2.84321300
116CENP-A containing nucleosome assembly (GO:0034080)2.84155024
117rRNA processing (GO:0006364)2.84133250
118gluconeogenesis (GO:0006094)2.83856817
119L-serine metabolic process (GO:0006563)2.83651526
120translational initiation (GO:0006413)2.83626766
121ribosomal small subunit biogenesis (GO:0042274)2.83018100
122RNA methylation (GO:0001510)2.82763309
123methionine biosynthetic process (GO:0009086)2.82189090
124sulfur amino acid catabolic process (GO:0000098)2.82076054
125methionine metabolic process (GO:0006555)2.81939581
126serine family amino acid biosynthetic process (GO:0009070)2.81511399
127serine family amino acid metabolic process (GO:0009069)2.80529596
128viral life cycle (GO:0019058)2.80389099
129peptidyl-arginine omega-N-methylation (GO:0035247)2.80175204
130valine metabolic process (GO:0006573)2.79182336
131pantothenate metabolic process (GO:0015939)2.78589788
132negative regulation of ligase activity (GO:0051352)2.77978483
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77978483
134quinone biosynthetic process (GO:1901663)2.76924640
135ubiquinone biosynthetic process (GO:0006744)2.76924640
136folic acid metabolic process (GO:0046655)2.76798349
137cellular component biogenesis (GO:0044085)2.76655912
138ribosomal large subunit biogenesis (GO:0042273)2.76650164
139protein deneddylation (GO:0000338)2.76062659
140SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74785882
141ribosome biogenesis (GO:0042254)2.73250685
142nucleotide salvage (GO:0043173)2.72437819
143negative regulation of cell killing (GO:0031342)2.72116287
144negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72116287
145positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.71764089
146lysine catabolic process (GO:0006554)2.70992254
147lysine metabolic process (GO:0006553)2.70992254
148proline biosynthetic process (GO:0006561)2.70904594
149serine family amino acid catabolic process (GO:0009071)2.70514647
150ribonucleoprotein complex biogenesis (GO:0022613)2.70180937
151monosaccharide biosynthetic process (GO:0046364)2.70041344
152regulation of oxidative phosphorylation (GO:0002082)2.69453930
153protein import into peroxisome matrix (GO:0016558)2.69211502
154cotranslational protein targeting to membrane (GO:0006613)2.69186365
155ATP biosynthetic process (GO:0006754)2.68866093
156positive regulation of synapse maturation (GO:0090129)2.68742103
157ubiquinone metabolic process (GO:0006743)2.68697782
158regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.68527052
159aerobic respiration (GO:0009060)2.68111300
160respiratory chain complex IV assembly (GO:0008535)2.67799291
161GMP metabolic process (GO:0046037)2.67538339
162anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65819235
163nucleoside salvage (GO:0043174)2.65122163
164translation (GO:0006412)2.65060501
165protein targeting to ER (GO:0045047)2.63452013
166aspartate family amino acid catabolic process (GO:0009068)2.63331778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.32774246
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66474126
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.63487412
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.57803593
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50472105
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22478417
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.15559246
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.12061972
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.11724518
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.04002758
11* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96557416
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.92401761
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.81198260
14E2F7_22180533_ChIP-Seq_HELA_Human2.49678492
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.47724547
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.41481401
17XRN2_22483619_ChIP-Seq_HELA_Human2.35134881
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27315061
19* YY1_21170310_ChIP-Seq_MESCs_Mouse2.24218865
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22303241
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21801864
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17887738
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.12341028
24* SRF_21415370_ChIP-Seq_HL-1_Mouse2.11013175
25DCP1A_22483619_ChIP-Seq_HELA_Human2.06969860
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.04607762
27* VDR_23849224_ChIP-Seq_CD4+_Human2.02818888
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00128963
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.95682444
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.95243121
31FOXP3_21729870_ChIP-Seq_TREG_Human1.93334198
32GABP_19822575_ChIP-Seq_HepG2_Human1.91849960
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91749442
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.82575234
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81723684
36CIITA_25753668_ChIP-Seq_RAJI_Human1.76728936
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75944611
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72396717
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.66640919
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63669485
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61149776
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.60334966
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59764368
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.59500881
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57262804
46MYC_22102868_ChIP-Seq_BL_Human1.56830157
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50698399
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.50482816
49TTF2_22483619_ChIP-Seq_HELA_Human1.46999320
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41775973
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41602156
52NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40837063
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40290883
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40086098
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33931344
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33816258
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33764906
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33571231
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33019907
60* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32633058
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31831482
62YY1_22570637_ChIP-Seq_MALME-3M_Human1.30870974
63* FOXP1_21924763_ChIP-Seq_HESCs_Human1.30522753
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29237826
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27774840
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24088647
67P68_20966046_ChIP-Seq_HELA_Human1.21554405
68BCL6_27268052_Chip-Seq_Bcells_Human1.20993161
69CTCF_18555785_ChIP-Seq_MESCs_Mouse1.20457607
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19017149
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.18834715
72KDM5A_27292631_Chip-Seq_BREAST_Human1.18484309
73EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17625949
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17072020
75HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15164591
76TET1_21451524_ChIP-Seq_MESCs_Mouse1.15015241
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13982655
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13562289
79* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12832931
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12631552
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11506295
82E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09273268
83* CTCF_21964334_Chip-Seq_Bcells_Human1.08366215
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06325316
85AR_21909140_ChIP-Seq_LNCAP_Human1.05680304
86VDR_21846776_ChIP-Seq_THP-1_Human1.04585674
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04482157
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.03948433
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03452823
90BCOR_27268052_Chip-Seq_Bcells_Human1.03387715
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02954919
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01487508
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01484070
94KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00901445
95KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00901445
96KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00901445
97GATA1_22025678_ChIP-Seq_K562_Human1.00412487
98RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.00170807
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99618241
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99376260
101KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98365376
102OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98107466
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97189655
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96339189
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94763590
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94444559
107PHF8_20622854_ChIP-Seq_HELA_Human0.94314979
108CTCF_20526341_ChIP-Seq_ESCs_Human0.93823652
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93297582
110ZNF263_19887448_ChIP-Seq_K562_Human0.93291640
111MYC_18940864_ChIP-ChIP_HL60_Human0.92421227
112* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92081715
113* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91736096
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.91275159
115TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91231385
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.91003221
117SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90981301
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90820438
119CTCF_26484167_Chip-Seq_Bcells_Mouse0.90665334
120E2F1_20622854_ChIP-Seq_HELA_Human0.90610721
121GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90602066
122LXR_22292898_ChIP-Seq_THP-1_Human0.89895084
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89715810
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89681702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.02811385
2MP0005360_urolithiasis3.97840833
3MP0003303_peritoneal_inflammation3.95965086
4MP0002139_abnormal_hepatobiliary_system3.43965466
5MP0005365_abnormal_bile_salt3.40478115
6MP0002822_catalepsy3.33920661
7MP0003806_abnormal_nucleotide_metabolis3.19474862
8MP0010030_abnormal_orbit_morphology3.11817728
9MP0005085_abnormal_gallbladder_physiolo3.10742616
10MP0009840_abnormal_foam_cell2.74703636
11MP0006036_abnormal_mitochondrial_physio2.72489320
12MP0003693_abnormal_embryo_hatching2.32632979
13MP0001919_abnormal_reproductive_system2.31435944
14MP0008932_abnormal_embryonic_tissue2.30173999
15MP0005332_abnormal_amino_acid2.25368801
16MP0001764_abnormal_homeostasis2.17432740
17MP0005423_abnormal_somatic_nervous2.12128591
18MP0006035_abnormal_mitochondrial_morpho2.09611495
19MP0008875_abnormal_xenobiotic_pharmacok2.05067534
20MP0002653_abnormal_ependyma_morphology1.98139138
21MP0010329_abnormal_lipoprotein_level1.95466955
22MP0001666_abnormal_nutrient_absorption1.92453191
23MP0002163_abnormal_gland_morphology1.86335672
24MP0001529_abnormal_vocalization1.80341241
25MP0002210_abnormal_sex_determination1.75943659
26MP0002638_abnormal_pupillary_reflex1.75606838
27MP0002751_abnormal_autonomic_nervous1.75425262
28MP0004215_abnormal_myocardial_fiber1.71888797
29MP0003646_muscle_fatigue1.64333846
30MP0006276_abnormal_autonomic_nervous1.64288507
31MP0002837_dystrophic_cardiac_calcinosis1.63864085
32MP0001905_abnormal_dopamine_level1.63461797
33MP0008872_abnormal_physiological_respon1.63191842
34MP0003123_paternal_imprinting1.62111820
35MP0008877_abnormal_DNA_methylation1.61583792
36MP0003786_premature_aging1.58730197
37MP0001293_anophthalmia1.57130878
38MP0001984_abnormal_olfaction1.52949197
39MP0004084_abnormal_cardiac_muscle1.49710768
40MP0006292_abnormal_olfactory_placode1.49192199
41MP0004036_abnormal_muscle_relaxation1.48267998
42MP0005389_reproductive_system_phenotype1.48039097
43MP0004957_abnormal_blastocyst_morpholog1.45418323
44MP0003656_abnormal_erythrocyte_physiolo1.42811843
45MP0000751_myopathy1.42783222
46MP0003868_abnormal_feces_composition1.41430531
47MP0005084_abnormal_gallbladder_morpholo1.38797126
48MP0006082_CNS_inflammation1.38713995
49MP0005584_abnormal_enzyme/coenzyme_acti1.38105542
50MP0003221_abnormal_cardiomyocyte_apopto1.36041353
51MP0005501_abnormal_skin_physiology1.33514644
52MP0002736_abnormal_nociception_after1.32427845
53MP0003763_abnormal_thymus_physiology1.31133520
54MP0003329_amyloid_beta_deposits1.31100701
55MP0001663_abnormal_digestive_system1.29596386
56MP0005319_abnormal_enzyme/_coenzyme1.28987149
57MP0005377_hearing/vestibular/ear_phenot1.27904219
58MP0003878_abnormal_ear_physiology1.27904219
59MP0002269_muscular_atrophy1.27357809
60MP0000678_abnormal_parathyroid_gland1.25473811
61MP0002254_reproductive_system_inflammat1.24446330
62MP0005330_cardiomyopathy1.23761659
63MP0004859_abnormal_synaptic_plasticity1.22980544
64MP0001853_heart_inflammation1.22532628
65MP0000467_abnormal_esophagus_morphology1.22496117
66MP0003635_abnormal_synaptic_transmissio1.22079969
67MP0003115_abnormal_respiratory_system1.21664268
68MP0003111_abnormal_nucleus_morphology1.20336236
69MP0005075_abnormal_melanosome_morpholog1.19604508
70MP0001145_abnormal_male_reproductive1.19134639
71MP0001346_abnormal_lacrimal_gland1.18799760
72MP0009745_abnormal_behavioral_response1.18128233
73MP0003880_abnormal_central_pattern1.17938672
74MP0003186_abnormal_redox_activity1.17405852
75MP0000609_abnormal_liver_physiology1.14138215
76MP0001929_abnormal_gametogenesis1.12413744
77MP0002132_abnormal_respiratory_system1.12059371
78MP0009697_abnormal_copulation1.11506734
79MP0005394_taste/olfaction_phenotype1.09943876
80MP0005499_abnormal_olfactory_system1.09943876
81MP0009379_abnormal_foot_pigmentation1.09553039
82MP0002735_abnormal_chemical_nociception1.09038576
83MP0004142_abnormal_muscle_tone1.08611001
84MP0000350_abnormal_cell_proliferation1.07254117
85MP0002064_seizures1.07149539
86MP0005551_abnormal_eye_electrophysiolog1.06786656
87MP0009765_abnormal_xenobiotic_induced1.06211304
88MP0002118_abnormal_lipid_homeostasis1.06179871
89MP0000653_abnormal_sex_gland1.05611075
90MP0000049_abnormal_middle_ear1.04614261
91MP0004133_heterotaxia1.03380665
92MP0008058_abnormal_DNA_repair1.02839904
93MP0005646_abnormal_pituitary_gland1.02484634
94MP0005381_digestive/alimentary_phenotyp1.01575666
95MP0005266_abnormal_metabolism1.01388978
96MP0003136_yellow_coat_color0.99697168
97MP0000313_abnormal_cell_death0.99474910
98MP0009672_abnormal_birth_weight0.99414505
99MP0010094_abnormal_chromosome_stability0.97053783
100MP0003937_abnormal_limbs/digits/tail_de0.96750757
101MP0002272_abnormal_nervous_system0.96368372
102MP0002089_abnormal_postnatal_growth/wei0.96287308
103MP0003077_abnormal_cell_cycle0.96129443
104MP0000026_abnormal_inner_ear0.94878439
105MP0003315_abnormal_perineum_morphology0.94456658
106MP0004085_abnormal_heartbeat0.93535369
107MP0002396_abnormal_hematopoietic_system0.93273297
108MP0002938_white_spotting0.93215950
109MP0002019_abnormal_tumor_incidence0.91453438
110MP0008873_increased_physiological_sensi0.90386793
111MP0003718_maternal_effect0.90320715
112MP0008007_abnormal_cellular_replicative0.89870845
113MP0005376_homeostasis/metabolism_phenot0.89668367
114MP0003698_abnormal_male_reproductive0.89350312
115MP0001664_abnormal_digestion0.89308408
116MP0000490_abnormal_crypts_of0.89272578
117MP0008789_abnormal_olfactory_epithelium0.89224725
118MP0000428_abnormal_craniofacial_morphol0.88997541
119MP0008874_decreased_physiological_sensi0.88947740
120MP0002063_abnormal_learning/memory/cond0.88819672
121MP0000358_abnormal_cell_content/0.88672397
122MP0008260_abnormal_autophagy0.87584649
123MP0002127_abnormal_cardiovascular_syste0.86953974
124MP0001486_abnormal_startle_reflex0.86772289
125MP0002160_abnormal_reproductive_system0.86106872
126MP0008569_lethality_at_weaning0.85142078
127MP0008995_early_reproductive_senescence0.85054645
128MP0004233_abnormal_muscle_weight0.83796715
129MP0004019_abnormal_vitamin_homeostasis0.83637555
130MP0001119_abnormal_female_reproductive0.83106015
131MP0001502_abnormal_circadian_rhythm0.83036918
132MP0000749_muscle_degeneration0.83034128
133MP0001968_abnormal_touch/_nociception0.82212362
134MP0009643_abnormal_urine_homeostasis0.81273683
135MP0002161_abnormal_fertility/fecundity0.81268756
136MP0002184_abnormal_innervation0.80982843
137MP0003567_abnormal_fetal_cardiomyocyte0.80411146
138MP0002080_prenatal_lethality0.79533236
139MP0005636_abnormal_mineral_homeostasis0.78955525
140MP0001544_abnormal_cardiovascular_syste0.78562360
141MP0005385_cardiovascular_system_phenoty0.78562360
142MP0005451_abnormal_body_composition0.78475932
143MP0003866_abnormal_defecation0.78330363
144MP0000689_abnormal_spleen_morphology0.78265768
145MP0003137_abnormal_impulse_conducting0.78242541
146MP0002722_abnormal_immune_system0.77991159
147MP0001963_abnormal_hearing_physiology0.77767107
148MP0002572_abnormal_emotion/affect_behav0.77553184
149MP0001286_abnormal_eye_development0.77401297
150MP0000685_abnormal_immune_system0.77269806
151MP0005535_abnormal_body_temperature0.75677518
152MP0005058_abnormal_lysosome_morphology0.75614682
153MP0000747_muscle_weakness0.75191045
154MP0002876_abnormal_thyroid_physiology0.74786270
155MP0003638_abnormal_response/metabolism_0.73813413
156MP0005386_behavior/neurological_phenoty0.73166090
157MP0004924_abnormal_behavior0.73166090
158MP0000703_abnormal_thymus_morphology0.72645096
159MP0001730_embryonic_growth_arrest0.72125002
160MP0000598_abnormal_liver_morphology0.71582378
161MP0002085_abnormal_embryonic_tissue0.71467274
162MP0002752_abnormal_somatic_nervous0.70555258
163MP0005380_embryogenesis_phenotype0.69724819
164MP0001672_abnormal_embryogenesis/_devel0.69724819
165MP0001188_hyperpigmentation0.67763907
166MP0000955_abnormal_spinal_cord0.66682265
167MP0003938_abnormal_ear_development0.65349719
168MP0002234_abnormal_pharynx_morphology0.65012911
169MP0005379_endocrine/exocrine_gland_phen0.64556697
170MP0005410_abnormal_fertilization0.64542030
171MP0008057_abnormal_DNA_replication0.62847614

Predicted human phenotypes

RankGene SetZ-score
1Long foot (HP:0001833)4.58735516
2Duplicated collecting system (HP:0000081)4.42504679
3Acute necrotizing encephalopathy (HP:0006965)4.35772512
4Hepatocellular necrosis (HP:0001404)4.24140214
5Hepatic necrosis (HP:0002605)4.22299051
6Abnormal mitochondria in muscle tissue (HP:0008316)4.15031929
7Acute encephalopathy (HP:0006846)4.08704903
8Abnormality of the renal collecting system (HP:0004742)4.05599042
9Mitochondrial inheritance (HP:0001427)4.05024333
10Increased CSF lactate (HP:0002490)3.98733367
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.88172165
12Cerebral edema (HP:0002181)3.67878571
13Abnormality of fatty-acid metabolism (HP:0004359)3.45512581
14Hypobetalipoproteinemia (HP:0003563)3.43053471
15Hypoplastic pelvis (HP:0008839)3.42457208
16Progressive macrocephaly (HP:0004481)3.38620150
17Lactic acidosis (HP:0003128)3.36055699
18Aplasia/Hypoplasia of the sacrum (HP:0008517)3.34717536
19Hyperglycinemia (HP:0002154)3.33708742
20Dicarboxylic aciduria (HP:0003215)3.27159812
21Abnormality of dicarboxylic acid metabolism (HP:0010995)3.27159812
22Reticulocytopenia (HP:0001896)3.25387657
23Increased serum lactate (HP:0002151)3.22992641
24Acute lymphatic leukemia (HP:0006721)3.22913305
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21943176
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.21629181
27Large for gestational age (HP:0001520)3.18296217
28Hyperglycinuria (HP:0003108)3.15930310
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10036445
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10036445
31Ragged-red muscle fibers (HP:0003200)3.08647032
32Increased serum pyruvate (HP:0003542)3.08469687
33Abnormality of glycolysis (HP:0004366)3.08469687
34Lethargy (HP:0001254)3.06200758
35Testicular atrophy (HP:0000029)2.97482831
36Increased muscle lipid content (HP:0009058)2.92851177
37Hyperlipoproteinemia (HP:0010980)2.92826855
38Renal cortical cysts (HP:0000803)2.92660001
39Increased intramyocellular lipid droplets (HP:0012240)2.90410999
40CNS demyelination (HP:0007305)2.90377272
41Cerebral hypomyelination (HP:0006808)2.88802189
42Ureteral duplication (HP:0000073)2.86575985
43Lipid accumulation in hepatocytes (HP:0006561)2.86340894
44Exercise intolerance (HP:0003546)2.82761882
45Delusions (HP:0000746)2.82478825
46Abnormality of glycine metabolism (HP:0010895)2.80096726
47Abnormality of serine family amino acid metabolism (HP:0010894)2.80096726
48Hyperammonemia (HP:0001987)2.78587206
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.73659993
50Abnormality of alanine metabolism (HP:0010916)2.73659993
51Hyperalaninemia (HP:0003348)2.73659993
52Myoglobinuria (HP:0002913)2.73317689
53Exercise-induced myalgia (HP:0003738)2.70581819
54Intrahepatic cholestasis (HP:0001406)2.69304392
55Severe muscular hypotonia (HP:0006829)2.66751920
56Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66233877
57Rhabdomyolysis (HP:0003201)2.63000562
58Respiratory failure (HP:0002878)2.62727230
59Emotional lability (HP:0000712)2.61896651
60Microvesicular hepatic steatosis (HP:0001414)2.61682168
61Ketosis (HP:0001946)2.61011428
62Adactyly (HP:0009776)2.60721691
63Renal Fanconi syndrome (HP:0001994)2.58977896
64Abnormality of monocarboxylic acid metabolism (HP:0010996)2.58673064
65Abnormality of cells of the erythroid lineage (HP:0012130)2.56512543
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.55860800
67Brushfield spots (HP:0001088)2.54990564
68Increased hepatocellular lipid droplets (HP:0006565)2.54566021
69Gout (HP:0001997)2.49604948
70Abnormal ventriculo-arterial connection (HP:0011563)2.48434891
71Transposition of the great arteries (HP:0001669)2.48434891
72Abnormal connection of the cardiac segments (HP:0011545)2.48434891
73Leukodystrophy (HP:0002415)2.48315013
74Abnormality of serum amino acid levels (HP:0003112)2.43130654
75Type I transferrin isoform profile (HP:0003642)2.42113558
76Delayed CNS myelination (HP:0002188)2.38987762
77Abnormal number of erythroid precursors (HP:0012131)2.38975827
78Hypoglycemic coma (HP:0001325)2.36215497
79Reduced antithrombin III activity (HP:0001976)2.32764540
80Broad distal phalanx of finger (HP:0009836)2.32036137
81Xanthomatosis (HP:0000991)2.31972830
82Ketoacidosis (HP:0001993)2.31674250
83Microretrognathia (HP:0000308)2.29882918
84Methylmalonic aciduria (HP:0012120)2.27573345
85Abnormal gallbladder physiology (HP:0012438)2.23620534
86Cholecystitis (HP:0001082)2.23620534
87Unsteady gait (HP:0002317)2.23314510
88Poor suck (HP:0002033)2.23284164
89Optic disc pallor (HP:0000543)2.20672055
90Progressive muscle weakness (HP:0003323)2.19658198
91Absent thumb (HP:0009777)2.18217800
92Prolonged neonatal jaundice (HP:0006579)2.18103597
93Vomiting (HP:0002013)2.17081540
94Abnormal protein glycosylation (HP:0012346)2.16397091
95Abnormal glycosylation (HP:0012345)2.16397091
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16397091
97Abnormal protein N-linked glycosylation (HP:0012347)2.16397091
98Thrombocytosis (HP:0001894)2.14851237
99Respiratory difficulties (HP:0002880)2.13725219
100Visual hallucinations (HP:0002367)2.13033816
101Abnormality of methionine metabolism (HP:0010901)2.09872161
102Macrocytic anemia (HP:0001972)2.08739931
103Prolonged partial thromboplastin time (HP:0003645)2.08345568
104Generalized aminoaciduria (HP:0002909)2.06306881
105Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05322133
106Cleft eyelid (HP:0000625)2.03469982
107Hypolipoproteinemia (HP:0010981)2.03413548
108External ear malformation (HP:0008572)2.02325025
109Metabolic acidosis (HP:0001942)2.01112685
110Pallor (HP:0000980)2.00902855
111Palpitations (HP:0001962)1.98799792
112Rough bone trabeculation (HP:0100670)1.98103641
113Deep venous thrombosis (HP:0002625)1.96584261
114Retinal dysplasia (HP:0007973)1.95810087
115Colon cancer (HP:0003003)1.94803818
116Dry hair (HP:0011359)1.94378602
117Autoamputation (HP:0001218)1.92039322
118Athetosis (HP:0002305)1.90938834
119Double outlet right ventricle (HP:0001719)1.89657141
120Congenital malformation of the right heart (HP:0011723)1.89657141
121Dysphonia (HP:0001618)1.89646328
122Aplastic anemia (HP:0001915)1.88691589
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88658412
124Hypokinesia (HP:0002375)1.88534843
125Progressive external ophthalmoplegia (HP:0000590)1.88434050
126Acute hepatic failure (HP:0006554)1.85223299
127Glycosuria (HP:0003076)1.84691021
128Abnormality of urine glucose concentration (HP:0011016)1.84691021
1293-Methylglutaconic aciduria (HP:0003535)1.83720873
130Meckel diverticulum (HP:0002245)1.82518860
131Gliosis (HP:0002171)1.81998565
132Pulmonary artery stenosis (HP:0004415)1.81773660
133Poikiloderma (HP:0001029)1.81459590
134Myokymia (HP:0002411)1.81320702
135Congenital ichthyosiform erythroderma (HP:0007431)1.80922655
136Polymicrogyria (HP:0002126)1.80151199
137Exertional dyspnea (HP:0002875)1.80115189
138Epiphyseal stippling (HP:0010655)1.79835280
139Generalized amyotrophy (HP:0003700)1.78443185
140Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.77886049
141Hyperbilirubinemia (HP:0002904)1.77533057
142Ventricular fibrillation (HP:0001663)1.76440234
143Sclerocornea (HP:0000647)1.75975119
144Multiple enchondromatosis (HP:0005701)1.75399056
145Truncus arteriosus (HP:0001660)1.74543251
146Abnormality of reticulocytes (HP:0004312)1.73924981
147Selective tooth agenesis (HP:0001592)1.73782779
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.73643674
149Abnormal pupillary function (HP:0007686)1.73030262
150Abnormality of the ileum (HP:0001549)1.71408425
151Depressed nasal ridge (HP:0000457)1.70279579
152Cortical visual impairment (HP:0100704)1.66529548
153Concave nail (HP:0001598)1.64784957
154Squamous cell carcinoma (HP:0002860)1.64077642
155Menstrual irregularities (HP:0000858)1.63938863
156Delayed myelination (HP:0012448)1.61386182
157Abnormality of cochlea (HP:0000375)1.60932405

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72211221
2TAOK14.48592848
3MKNK14.46975839
4TAOK24.08136070
5BCKDK3.76616735
6VRK23.69997175
7EIF2AK12.90306457
8EIF2AK32.85967372
9MAP3K32.39379674
10NME22.35813324
11STK162.34544300
12MAP2K42.33019554
13NME12.22582729
14TSSK62.19521036
15MAP2K32.07157404
16BRAF2.03770136
17ABL21.98501051
18WEE11.96544845
19MAP4K11.95738274
20NEK11.92253561
21EPHA41.86901774
22ARAF1.85469222
23TIE11.84135156
24MAP2K61.79105848
25PDK31.70619316
26PDK41.70619316
27TRIM281.67727919
28CHEK21.64591607
29MAP3K41.54117783
30SMG11.51584901
31ZAK1.50602320
32MYLK1.49344179
33MAP3K131.39668961
34KDR1.38935218
35PHKG21.38082615
36PHKG11.38082615
37RAF11.36421251
38JAK31.36246179
39NEK21.34170539
40IRAK31.33586407
41CAMKK21.30837699
42DYRK21.30599940
43DYRK1A1.30146472
44GRK61.30056776
45TAF11.26169383
46DAPK11.24971035
47IRAK21.24795265
48FLT31.24073410
49MAP2K71.23830113
50ADRBK21.23719938
51PKN21.21873145
52PLK41.17883276
53DYRK31.15945618
54MAP2K21.10929127
55MAP3K81.07589117
56TLK11.06109676
57NUAK11.03858486
58PIM21.02190643
59MAP3K50.95010840
60PINK10.93737099
61VRK10.93271397
62MAP3K110.92608971
63AKT30.92240749
64LMTK20.90775564
65INSRR0.90230877
66TNIK0.90015187
67EIF2AK20.89794576
68PIK3CG0.88097228
69BRSK10.84433559
70RPS6KB20.84377420
71MINK10.83559610
72SRPK10.82313216
73MUSK0.81523802
74DAPK30.80200512
75CAMK10.74562185
76CAMKK10.74169712
77PRKD30.72179111
78RIPK10.71653200
79CDK190.71445613
80ACVR1B0.71223070
81IRAK40.69202964
82UHMK10.66825010
83PRKCG0.66044143
84MAPK120.65982301
85ZAP700.65576577
86MAPK40.63975428
87TNK20.63942314
88PLK10.63547574
89MAP3K60.62772983
90CDK70.62251220
91MAP3K10.60634270
92MAP3K90.59256653
93PNCK0.57868613
94DAPK20.57630023
95MAP3K120.57149671
96CASK0.56918183
97CCNB10.56322793
98MATK0.54262223
99ATR0.54048971
100SYK0.52574636
101CSNK1G20.51911396
102PASK0.47922837
103CAMK2G0.47527634
104PLK30.47237320
105TTK0.47066038
106CSNK1A1L0.46830008
107ILK0.46459849
108CSNK1G30.45043365
109PDK20.44175501
110OBSCN0.43483557
111PRKCI0.42622578
112CSNK2A20.42049766
113CHEK10.41525434
114CSNK1G10.41158173
115CDC70.40552706
116RPS6KA40.40182980
117TESK20.39533315
118TYK20.38579393
119FES0.37739322
120MAPK70.37556582
121TBK10.36341232
122AURKA0.36071632
123WNK30.34888113
124WNK40.34335668
125AURKB0.32978363
126TXK0.32586950
127TESK10.31992924
128PAK60.31890173
129CAMK40.30448602
130IKBKE0.30429440
131AKT20.30163084
132PBK0.29658809
133CSF1R0.27970901
134CDK11A0.27947108
135CSNK2A10.27772979
136MKNK20.27679838
137CDK40.27119383
138MAP3K70.26712236
139CDK80.26617596
140CDK20.22960138
141CSNK1A10.21898394
142DYRK1B0.21569374
143CDK10.20658828
144BMX0.20217144
145PAK10.19360668
146SIK30.19338531
147CSNK1E0.17864736
148MAP4K20.17453400
149CDK150.16814560
150STK40.15550830
151CDK180.15154872
152CAMK1D0.13036201
153GRK50.12870052
154SIK20.12536686
155CDK140.12329058
156LRRK20.10757366

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35811849
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.14288418
3Proteasome_Homo sapiens_hsa030503.09348642
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.95344669
5Ribosome_Homo sapiens_hsa030102.92332435
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63173889
7Parkinsons disease_Homo sapiens_hsa050122.56994668
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.56333328
9Oxidative phosphorylation_Homo sapiens_hsa001902.56254123
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.46987608
11Biosynthesis of amino acids_Homo sapiens_hsa012302.38403697
12Carbon metabolism_Homo sapiens_hsa012002.28759295
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.18541649
14Cysteine and methionine metabolism_Homo sapiens_hsa002702.11012072
15Propanoate metabolism_Homo sapiens_hsa006402.03813270
16Mismatch repair_Homo sapiens_hsa034302.00548885
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.99496260
18DNA replication_Homo sapiens_hsa030301.93563274
19Folate biosynthesis_Homo sapiens_hsa007901.90976480
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87111829
21RNA polymerase_Homo sapiens_hsa030201.84098742
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83830096
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83786631
24Pyruvate metabolism_Homo sapiens_hsa006201.80225134
25Sulfur relay system_Homo sapiens_hsa041221.75875247
26Pentose phosphate pathway_Homo sapiens_hsa000301.73552490
27Huntingtons disease_Homo sapiens_hsa050161.72534778
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.71666605
29Fatty acid degradation_Homo sapiens_hsa000711.68572770
30Fructose and mannose metabolism_Homo sapiens_hsa000511.57938713
31Arginine biosynthesis_Homo sapiens_hsa002201.53834689
32Pyrimidine metabolism_Homo sapiens_hsa002401.52900708
33Alzheimers disease_Homo sapiens_hsa050101.51107756
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46921020
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45658277
36Peroxisome_Homo sapiens_hsa041461.40881329
37Base excision repair_Homo sapiens_hsa034101.39095521
38Butanoate metabolism_Homo sapiens_hsa006501.37337915
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.34317886
40Cardiac muscle contraction_Homo sapiens_hsa042601.33935338
41Cell cycle_Homo sapiens_hsa041101.29818063
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.26664553
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25529169
44Steroid biosynthesis_Homo sapiens_hsa001001.24360206
45Nitrogen metabolism_Homo sapiens_hsa009101.24253572
46Nucleotide excision repair_Homo sapiens_hsa034201.18825949
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16932207
48Fatty acid metabolism_Homo sapiens_hsa012121.13441215
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11195536
50Vitamin B6 metabolism_Homo sapiens_hsa007501.09633684
51Protein export_Homo sapiens_hsa030601.08677288
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06908032
53Homologous recombination_Homo sapiens_hsa034401.06848861
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05986374
55Spliceosome_Homo sapiens_hsa030401.04504541
56Non-homologous end-joining_Homo sapiens_hsa034500.97299294
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96782307
58Tryptophan metabolism_Homo sapiens_hsa003800.96406871
59Galactose metabolism_Homo sapiens_hsa000520.95151705
60Purine metabolism_Homo sapiens_hsa002300.92700421
61Caffeine metabolism_Homo sapiens_hsa002320.88215829
62mRNA surveillance pathway_Homo sapiens_hsa030150.86191667
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81514051
64Primary immunodeficiency_Homo sapiens_hsa053400.80114296
65Metabolic pathways_Homo sapiens_hsa011000.79131486
66Taste transduction_Homo sapiens_hsa047420.78163845
67RNA transport_Homo sapiens_hsa030130.77773596
68beta-Alanine metabolism_Homo sapiens_hsa004100.75845946
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75770661
70p53 signaling pathway_Homo sapiens_hsa041150.74991258
71Selenocompound metabolism_Homo sapiens_hsa004500.74288538
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73360214
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62342707
74Olfactory transduction_Homo sapiens_hsa047400.62074290
75Phenylalanine metabolism_Homo sapiens_hsa003600.61863534
76Arginine and proline metabolism_Homo sapiens_hsa003300.59235076
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58903471
78Oocyte meiosis_Homo sapiens_hsa041140.57309375
79Lysine degradation_Homo sapiens_hsa003100.56958470
80Fatty acid elongation_Homo sapiens_hsa000620.56357374
81Synaptic vesicle cycle_Homo sapiens_hsa047210.52842177
82Basal transcription factors_Homo sapiens_hsa030220.51959946
83Tyrosine metabolism_Homo sapiens_hsa003500.51126423
84Starch and sucrose metabolism_Homo sapiens_hsa005000.48977534
85One carbon pool by folate_Homo sapiens_hsa006700.48145185
86Chemical carcinogenesis_Homo sapiens_hsa052040.47363473
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46156899
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45454587
89Bile secretion_Homo sapiens_hsa049760.44981168
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44766862
91PPAR signaling pathway_Homo sapiens_hsa033200.44209978
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43512070
93N-Glycan biosynthesis_Homo sapiens_hsa005100.42834629
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42085584
95Glutathione metabolism_Homo sapiens_hsa004800.41677608
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39766880
97Sulfur metabolism_Homo sapiens_hsa009200.38641693
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36849441
99Basal cell carcinoma_Homo sapiens_hsa052170.35554428
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35427618
101Nicotine addiction_Homo sapiens_hsa050330.34297327
102Regulation of autophagy_Homo sapiens_hsa041400.33732980
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30761245
104Vibrio cholerae infection_Homo sapiens_hsa051100.30250381
105Glucagon signaling pathway_Homo sapiens_hsa049220.29948469
106Circadian rhythm_Homo sapiens_hsa047100.29030038
107Histidine metabolism_Homo sapiens_hsa003400.28422390
108Amphetamine addiction_Homo sapiens_hsa050310.27763880
109GABAergic synapse_Homo sapiens_hsa047270.26656125
110RNA degradation_Homo sapiens_hsa030180.26566074
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.26203600
112Retinol metabolism_Homo sapiens_hsa008300.25808790
113Phototransduction_Homo sapiens_hsa047440.25685484
114Epstein-Barr virus infection_Homo sapiens_hsa051690.25007295
115Bladder cancer_Homo sapiens_hsa052190.22666837
116ABC transporters_Homo sapiens_hsa020100.22396956
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21366200
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.21319719
119Dopaminergic synapse_Homo sapiens_hsa047280.17644287
120Collecting duct acid secretion_Homo sapiens_hsa049660.16315493
121Fanconi anemia pathway_Homo sapiens_hsa034600.15067786
122Calcium signaling pathway_Homo sapiens_hsa040200.15036091
123Notch signaling pathway_Homo sapiens_hsa043300.10299104
124Other glycan degradation_Homo sapiens_hsa005110.10206072
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08762669
126AMPK signaling pathway_Homo sapiens_hsa041520.07730579
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.06039056
128Herpes simplex infection_Homo sapiens_hsa051680.02294210
129RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00985016
130Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0018526

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