KRAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.38921387
2layer formation in cerebral cortex (GO:0021819)4.27516564
3establishment of integrated proviral latency (GO:0075713)4.23953296
4locomotory exploration behavior (GO:0035641)4.16097281
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08925978
6paraxial mesoderm development (GO:0048339)4.06223900
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03348104
8synaptic vesicle maturation (GO:0016188)4.02448416
9nuclear pore organization (GO:0006999)3.84102507
10regulation of synaptic vesicle exocytosis (GO:2000300)3.79536104
11glutamate secretion (GO:0014047)3.70775498
12synaptic vesicle exocytosis (GO:0016079)3.65962830
13generation of neurons (GO:0048699)3.64284575
14heterochromatin organization (GO:0070828)3.57874672
15NLS-bearing protein import into nucleus (GO:0006607)3.57768179
16dendritic spine morphogenesis (GO:0060997)3.48252365
17axonal fasciculation (GO:0007413)3.46489668
18exploration behavior (GO:0035640)3.41136337
19dendrite morphogenesis (GO:0048813)3.40298505
20lateral sprouting from an epithelium (GO:0060601)3.33677875
21regulation of DNA endoreduplication (GO:0032875)3.32041617
22protein targeting to Golgi (GO:0000042)3.29581209
23radial glial cell differentiation (GO:0060019)3.26749624
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.26154361
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.26154361
26regulation of translation, ncRNA-mediated (GO:0045974)3.26154361
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.25750211
28regulation of transforming growth factor beta2 production (GO:0032909)3.24520537
29vesicle transport along microtubule (GO:0047496)3.24402090
30neuron recognition (GO:0008038)3.20355424
31regulation of gene silencing by RNA (GO:0060966)3.19368429
32regulation of posttranscriptional gene silencing (GO:0060147)3.19368429
33regulation of gene silencing by miRNA (GO:0060964)3.19368429
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.15604601
35vocalization behavior (GO:0071625)3.15528460
36chondrocyte development (GO:0002063)3.09659191
37protein localization to endosome (GO:0036010)3.08386797
38negative regulation of fibroblast apoptotic process (GO:2000270)3.07382113
39regulation of clathrin-mediated endocytosis (GO:2000369)3.05282623
40notochord development (GO:0030903)3.02529905
41DNA double-strand break processing (GO:0000729)3.01808225
42regulation of RNA export from nucleus (GO:0046831)3.01595210
43neuron cell-cell adhesion (GO:0007158)3.00987429
44regulation of synaptic vesicle transport (GO:1902803)3.00175987
45chromatin remodeling at centromere (GO:0031055)2.96560700
46pore complex assembly (GO:0046931)2.96212514
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93507428
48regulation of growth hormone secretion (GO:0060123)2.89727341
49protein localization to synapse (GO:0035418)2.89477609
50neuronal action potential propagation (GO:0019227)2.89210863
51mRNA splice site selection (GO:0006376)2.87799462
52dendritic spine organization (GO:0097061)2.87600909
53regulation of dendritic spine morphogenesis (GO:0061001)2.87058506
54establishment of protein localization to Golgi (GO:0072600)2.86188770
55protein localization to kinetochore (GO:0034501)2.86176175
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85752569
57pyrimidine nucleobase catabolic process (GO:0006208)2.85650168
58membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.85284301
59retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84585350
60innervation (GO:0060384)2.83997384
61organelle transport along microtubule (GO:0072384)2.83936543
62dorsal/ventral axis specification (GO:0009950)2.83885852
63axon extension (GO:0048675)2.83811324
64negative regulation of keratinocyte proliferation (GO:0010839)2.82934471
65DNA topological change (GO:0006265)2.81779112
66ventricular trabecula myocardium morphogenesis (GO:0003222)2.81542506
67cytoskeletal anchoring at plasma membrane (GO:0007016)2.79941588
68presynaptic membrane assembly (GO:0097105)2.79686960
69cell surface receptor signaling pathway involved in heart development (GO:0061311)2.79269539
70activation of protein kinase A activity (GO:0034199)2.78965513
71CENP-A containing nucleosome assembly (GO:0034080)2.78817122
72inner ear receptor cell development (GO:0060119)2.78204112
73negative regulation of NF-kappaB import into nucleus (GO:0042347)2.76640432
74clathrin coat assembly (GO:0048268)2.76250982
75establishment of viral latency (GO:0019043)2.75873756
76neurotransmitter secretion (GO:0007269)2.75378732
77positive regulation of mRNA processing (GO:0050685)2.74681776
78regulation of glutamate receptor signaling pathway (GO:1900449)2.73830974
79somatic stem cell division (GO:0048103)2.73763657
80regulation of DNA methylation (GO:0044030)2.73650087
81cellular potassium ion homeostasis (GO:0030007)2.72673444
82positive regulation of vesicle fusion (GO:0031340)2.71892976
83negative regulation of cell killing (GO:0031342)2.70699803
84negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.70699803
85* regulation of long-term neuronal synaptic plasticity (GO:0048169)2.70574550
86cell fate commitment involved in formation of primary germ layer (GO:0060795)2.70404906
87regulation of neuron migration (GO:2001222)2.66404254
88cytoplasmic mRNA processing body assembly (GO:0033962)2.65914943
89ectodermal placode formation (GO:0060788)2.64797138
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.63979929
91proline transport (GO:0015824)2.63694122
92apical protein localization (GO:0045176)2.63369107
93proximal/distal pattern formation (GO:0009954)2.63026834
94ATP-dependent chromatin remodeling (GO:0043044)2.62919286
95SMAD protein complex assembly (GO:0007183)2.62780379
96positive regulation of dendritic spine morphogenesis (GO:0061003)2.62628636
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.62354691
98stem cell division (GO:0017145)2.62276883
99acrosome assembly (GO:0001675)2.61225082
100positive regulation of chromosome segregation (GO:0051984)2.60934984
101chemosensory behavior (GO:0007635)2.60632343
102positive regulation of cell cycle G2/M phase transition (GO:1902751)2.60128119
103positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.60128119
104presynaptic membrane organization (GO:0097090)2.59604382
105regulation of mRNA 3-end processing (GO:0031440)2.58518266
106histone exchange (GO:0043486)2.58266312
107DNA replication-independent nucleosome organization (GO:0034724)2.58017565
108DNA replication-independent nucleosome assembly (GO:0006336)2.58017565
109neuron projection extension (GO:1990138)2.57313142
110protein complex localization (GO:0031503)2.57000894
111body morphogenesis (GO:0010171)2.56836778
112glutamate receptor signaling pathway (GO:0007215)2.56437081
113ionotropic glutamate receptor signaling pathway (GO:0035235)2.56215088
114mitotic sister chromatid cohesion (GO:0007064)2.55769738
115glucocorticoid receptor signaling pathway (GO:0042921)2.55725492
116single strand break repair (GO:0000012)2.55612262
117membrane repolarization during action potential (GO:0086011)2.55170066
118regulation of cell fate specification (GO:0042659)2.54427844
119negative regulation of DNA-dependent DNA replication (GO:2000104)2.53625668
120regulation of histone H3-K9 methylation (GO:0051570)2.52856327
121synaptic vesicle endocytosis (GO:0048488)2.52025597
122cellular protein complex localization (GO:0034629)2.51083699
123keratinocyte development (GO:0003334)2.50721801
124embryonic body morphogenesis (GO:0010172)2.50620842
125gamma-aminobutyric acid signaling pathway (GO:0007214)2.50438897
126mitotic metaphase plate congression (GO:0007080)2.49851845
127negative regulation of DNA recombination (GO:0045910)2.49738514
128positive regulation of histone H3-K4 methylation (GO:0051571)2.49690560
129long-term synaptic potentiation (GO:0060291)2.49426641
130positive regulation of mRNA 3-end processing (GO:0031442)2.48688042
131suckling behavior (GO:0001967)2.47059449
132hippo signaling (GO:0035329)2.46949083
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.46758147
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.46758147
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.46758147
136L-serine metabolic process (GO:0006563)2.46267216
137kidney morphogenesis (GO:0060993)2.46209652
138regulation of helicase activity (GO:0051095)2.46194542
139nerve growth factor signaling pathway (GO:0038180)2.46181547
140appendage development (GO:0048736)2.46088590
141limb development (GO:0060173)2.46088590
142regulation of vesicle fusion (GO:0031338)2.46046989
143nodal signaling pathway (GO:0038092)2.45918355
144negative regulation of RNA splicing (GO:0033119)2.44493896
145* regulation of neuronal synaptic plasticity (GO:0048168)2.44316796
146regulation of chromatin silencing (GO:0031935)2.44249201
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44148237
148histone H3-K36 demethylation (GO:0070544)2.43813198
149negative regulation of mRNA metabolic process (GO:1903312)2.43515367
150sodium ion export (GO:0071436)2.43334437
151cell migration in hindbrain (GO:0021535)2.43140768
152positive regulation of SMAD protein import into nucleus (GO:0060391)2.41200861
153Notch signaling involved in heart development (GO:0061314)2.40898479
154negative regulation of histone methylation (GO:0031061)2.40286706
155protein localization to chromosome, centromeric region (GO:0071459)2.39547000
156heart trabecula morphogenesis (GO:0061384)2.39157365
157histone H2B ubiquitination (GO:0033523)2.38959697
158positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.38901930
159regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.38901930
160central nervous system projection neuron axonogenesis (GO:0021952)2.38790643
161ribosome assembly (GO:0042255)2.37425338
162regulation of excitatory postsynaptic membrane potential (GO:0060079)2.37181559
163synaptic transmission, glutamatergic (GO:0035249)2.36972754
164histone ubiquitination (GO:0016574)2.36288371
165regulation of dendritic spine development (GO:0060998)2.36208706
166myoblast migration (GO:0051451)2.35511833
167regulation of nucleobase-containing compound transport (GO:0032239)2.34846584
168stress granule assembly (GO:0034063)2.32650043
169postsynaptic membrane organization (GO:0001941)2.32482009
170regulation of sister chromatid cohesion (GO:0007063)2.30963002
171cerebellum development (GO:0021549)2.30430448
172neuron-neuron synaptic transmission (GO:0007270)2.29442379
173regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.28896666
174negative regulation of neurotransmitter secretion (GO:0046929)2.28104651
175* regulation of synaptic plasticity (GO:0048167)2.28077540
176peptidyl-threonine phosphorylation (GO:0018107)2.27475570
177cerebellar Purkinje cell differentiation (GO:0021702)2.26147569
178* regulation of Rac protein signal transduction (GO:0035020)2.25816044
179regulation of postsynaptic membrane potential (GO:0060078)2.25116212
180regulation of neurotransmitter secretion (GO:0046928)2.23527311
181establishment of nucleus localization (GO:0040023)2.23075870
182long-term memory (GO:0007616)2.22503469
183regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.22429599
184negative regulation of hormone metabolic process (GO:0032351)2.21817961
185negative regulation of hormone biosynthetic process (GO:0032353)2.21817961
186regulation of ARF protein signal transduction (GO:0032012)2.21745316
187synapse organization (GO:0050808)2.21097660
188transmission of nerve impulse (GO:0019226)2.20725163
189ephrin receptor signaling pathway (GO:0048013)2.20707532
190pre-miRNA processing (GO:0031054)2.20239873
191asymmetric protein localization (GO:0008105)2.17710196

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.40407187
2EZH2_22144423_ChIP-Seq_EOC_Human2.88051450
3E2F7_22180533_ChIP-Seq_HELA_Human2.84902627
4GBX2_23144817_ChIP-Seq_PC3_Human2.68475224
5* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.56349141
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.38903977
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35035755
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35035755
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35035755
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.32732245
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28318460
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.27402552
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15750495
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.12675319
15ZNF217_24962896_ChIP-Seq_MCF-7_Human2.09699946
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.07222954
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02765721
18AR_21572438_ChIP-Seq_LNCaP_Human2.01721234
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.99373260
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95847743
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93961065
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.88330675
23ELK1_19687146_ChIP-ChIP_HELA_Human1.87166122
24WT1_19549856_ChIP-ChIP_CCG9911_Human1.86058432
25* FOXM1_23109430_ChIP-Seq_U2OS_Human1.85817122
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84428226
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82544457
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.80944089
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79951051
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79951051
31AR_21909140_ChIP-Seq_LNCAP_Human1.77698273
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75934615
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.73383977
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70866649
35TP53_16413492_ChIP-PET_HCT116_Human1.69117165
36IGF1R_20145208_ChIP-Seq_DFB_Human1.68628479
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.68059585
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.67350987
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67209067
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65841604
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64829536
42FUS_26573619_Chip-Seq_HEK293_Human1.63084306
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.62118661
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.58610936
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57727562
46SMAD4_21799915_ChIP-Seq_A2780_Human1.57268574
47* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.56505935
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56433183
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56243012
50FLI1_27457419_Chip-Seq_LIVER_Mouse1.53530435
51ZNF274_21170338_ChIP-Seq_K562_Hela1.53205312
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.52008188
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52005402
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51906108
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47825738
56* REST_21632747_ChIP-Seq_MESCs_Mouse1.46660803
57P300_19829295_ChIP-Seq_ESCs_Human1.45976871
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44559095
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.43639096
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43585527
61TRIM28_21343339_ChIP-Seq_HEK293_Human1.43481142
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.42811136
63DROSHA_22980978_ChIP-Seq_HELA_Human1.42593917
64* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41999545
65DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41282830
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.40267141
67STAT3_23295773_ChIP-Seq_U87_Human1.39637323
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39132294
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.38418458
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37859140
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.37601653
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36869249
73AHR_22903824_ChIP-Seq_MCF-7_Human1.36613495
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.36534862
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.36155752
76* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34657291
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34062623
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33641258
79TP53_18474530_ChIP-ChIP_U2OS_Human1.33187477
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31939351
81MYC_18555785_ChIP-Seq_MESCs_Mouse1.30740557
82* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30516952
83* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30440306
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27302332
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.27232683
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27121051
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.26958275
88POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.26320632
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24172876
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23334131
91E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23315577
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22342615
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21906684
94* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21827728
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.21577551
96* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21500517
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20086667
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19559344
99EWS_26573619_Chip-Seq_HEK293_Human1.19170770
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.18664511
101EGR1_19374776_ChIP-ChIP_THP-1_Human1.18224846
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17916567
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17549984
104FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17345201
105AR_19668381_ChIP-Seq_PC3_Human1.17167521
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16031876
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15893713
108* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15283106
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.14651049
110GATA1_26923725_Chip-Seq_HPCs_Mouse1.14314211
111TCF4_18268006_ChIP-ChIP_LS174T_Human1.13883358
112PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13615045
113RXR_22108803_ChIP-Seq_LS180_Human1.13558273
114ISL1_27105846_Chip-Seq_CPCs_Mouse1.13193190
115PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12915491
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12624911
117E2F1_21310950_ChIP-Seq_MCF-7_Human1.12553681
118TAF15_26573619_Chip-Seq_HEK293_Human1.12175430
119NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12064505
120EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11753535
121BCAT_22108803_ChIP-Seq_LS180_Human1.11191297
122TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11067341
123* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11044528
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10747644
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10307081
126TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10063354
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.10002930
128TBX3_20139965_ChIP-Seq_ESCs_Mouse1.09736682
129* KDM2B_26808549_Chip-Seq_K562_Human1.09384537
130RNF2_27304074_Chip-Seq_NSC_Mouse1.08967822
131ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.08797829
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08621440
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07675207
134* TCF4_23295773_ChIP-Seq_U87_Human1.07168129
135STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07110570
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07005626
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07005626
138TCF3_18692474_ChIP-Seq_MESCs_Mouse1.06814975
139BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05977426
140* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05125162
141* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04800927
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04466632
143REST_18959480_ChIP-ChIP_MESCs_Mouse1.04136829
144SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.03911148
145AR_25329375_ChIP-Seq_VCAP_Human1.03156156
146MYC_19079543_ChIP-ChIP_MESCs_Mouse1.03032655
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02259669
148P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00864880
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00803755
150SALL4_18804426_ChIP-ChIP_XEN_Mouse0.99857003
151RUNX2_22187159_ChIP-Seq_PCA_Human0.99724819
152GABP_17652178_ChIP-ChIP_JURKAT_Human0.99558461
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98971798
154KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98282789
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98019671
156CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98007874
157NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97252632
158CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96733390
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95834565
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93471682
161SOX9_26525672_Chip-Seq_HEART_Mouse0.93261399

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.36980055
2MP0004270_analgesia3.56491827
3MP0008057_abnormal_DNA_replication3.04897985
4MP0000537_abnormal_urethra_morphology2.94782594
5MP0009780_abnormal_chondrocyte_physiolo2.92048094
6MP0003635_abnormal_synaptic_transmissio2.90593944
7MP0000579_abnormal_nail_morphology2.75645421
8MP0003787_abnormal_imprinting2.61292976
9MP0004957_abnormal_blastocyst_morpholog2.48730223
10MP0003941_abnormal_skin_development2.43600064
11MP0008877_abnormal_DNA_methylation2.41374355
12MP0002063_abnormal_learning/memory/cond2.38290033
13MP0006292_abnormal_olfactory_placode2.26578333
14MP0005187_abnormal_penis_morphology2.22938935
15MP0003880_abnormal_central_pattern2.22626659
16MP0010234_abnormal_vibrissa_follicle2.17897338
17MP0002909_abnormal_adrenal_gland2.16829849
18* MP0002877_abnormal_melanocyte_morpholog2.12445747
19MP0001293_anophthalmia2.11389402
20MP0003300_gastrointestinal_ulcer2.10250853
21MP0005076_abnormal_cell_differentiation1.97008852
22MP0002009_preneoplasia1.95938442
23MP0002734_abnormal_mechanical_nocicepti1.90053631
24MP0002233_abnormal_nose_morphology1.86197319
25MP0009745_abnormal_behavioral_response1.86112434
26MP0003123_paternal_imprinting1.85943480
27MP0000778_abnormal_nervous_system1.84871422
28MP0002572_abnormal_emotion/affect_behav1.82552367
29MP0002697_abnormal_eye_size1.82444828
30MP0003122_maternal_imprinting1.79464123
31MP0000013_abnormal_adipose_tissue1.77411515
32MP0001299_abnormal_eye_distance/1.68203876
33MP0005623_abnormal_meninges_morphology1.68200884
34MP0003303_peritoneal_inflammation1.67215336
35MP0003283_abnormal_digestive_organ1.65547192
36* MP0003567_abnormal_fetal_cardiomyocyte1.65409207
37MP0002064_seizures1.64280513
38MP0006072_abnormal_retinal_apoptosis1.63491481
39MP0003119_abnormal_digestive_system1.58720239
40MP0000516_abnormal_urinary_system1.55325574
41MP0005367_renal/urinary_system_phenotyp1.55325574
42MP0010030_abnormal_orbit_morphology1.55101600
43MP0001968_abnormal_touch/_nociception1.54130842
44MP0008789_abnormal_olfactory_epithelium1.53051632
45MP0003121_genomic_imprinting1.52071341
46MP0003705_abnormal_hypodermis_morpholog1.51482144
47MP0003077_abnormal_cell_cycle1.50551834
48MP0008932_abnormal_embryonic_tissue1.50112494
49MP0003693_abnormal_embryo_hatching1.47324082
50MP0003111_abnormal_nucleus_morphology1.47284007
51MP0003890_abnormal_embryonic-extraembry1.44822362
52MP0005423_abnormal_somatic_nervous1.44246428
53MP0002102_abnormal_ear_morphology1.44008461
54* MP0002085_abnormal_embryonic_tissue1.43893262
55MP0010352_gastrointestinal_tract_polyps1.41783919
56MP0002184_abnormal_innervation1.41477099
57MP0010094_abnormal_chromosome_stability1.40472753
58* MP0004811_abnormal_neuron_physiology1.39978480
59MP0008058_abnormal_DNA_repair1.38755352
60MP0002896_abnormal_bone_mineralization1.38571862
61MP0002733_abnormal_thermal_nociception1.37070244
62MP0001486_abnormal_startle_reflex1.36977768
63MP0009672_abnormal_birth_weight1.35330477
64MP0010678_abnormal_skin_adnexa1.33936117
65* MP0005380_embryogenesis_phenotype1.30012844
66* MP0001672_abnormal_embryogenesis/_devel1.30012844
67MP0004885_abnormal_endolymph1.29906429
68MP0001485_abnormal_pinna_reflex1.29661442
69* MP0000350_abnormal_cell_proliferation1.28003658
70MP0002272_abnormal_nervous_system1.26579515
71* MP0001697_abnormal_embryo_size1.25379433
72* MP0002088_abnormal_embryonic_growth/wei1.23949378
73* MP0001730_embryonic_growth_arrest1.23509177
74MP0000762_abnormal_tongue_morphology1.23079565
75* MP0003984_embryonic_growth_retardation1.22943331
76MP0003136_yellow_coat_color1.22502544
77MP0005394_taste/olfaction_phenotype1.20688681
78MP0005499_abnormal_olfactory_system1.20688681
79MP0000647_abnormal_sebaceous_gland1.20308767
80MP0002557_abnormal_social/conspecific_i1.20166744
81MP0005409_darkened_coat_color1.18145797
82MP0002234_abnormal_pharynx_morphology1.17844581
83MP0002735_abnormal_chemical_nociception1.17283544
84MP0003938_abnormal_ear_development1.17060936
85MP0000955_abnormal_spinal_cord1.13936585
86MP0002092_abnormal_eye_morphology1.11543768
87* MP0002152_abnormal_brain_morphology1.11177630
88MP0001970_abnormal_pain_threshold1.11059408
89* MP0003385_abnormal_body_wall1.10946977
90MP0000631_abnormal_neuroendocrine_gland1.10312445
91MP0002882_abnormal_neuron_morphology1.09216643
92MP0000569_abnormal_digit_pigmentation1.08782670
93MP0004133_heterotaxia1.08072742
94MP0004924_abnormal_behavior1.06853553
95MP0005386_behavior/neurological_phenoty1.06853553
96MP0002067_abnormal_sensory_capabilities1.06467376
97* MP0003861_abnormal_nervous_system1.05884087
98* MP0002086_abnormal_extraembryonic_tissu1.04308978
99MP0000003_abnormal_adipose_tissue1.04031638
100MP0004264_abnormal_extraembryonic_tissu1.03737251
101* MP0002111_abnormal_tail_morphology1.03323959
102MP0009046_muscle_twitch1.01848219
103MP0009053_abnormal_anal_canal1.01242366
104MP0003942_abnormal_urinary_system0.99392510
105MP0001440_abnormal_grooming_behavior0.97689078
106MP0003935_abnormal_craniofacial_develop0.96646268
107MP0000377_abnormal_hair_follicle0.96427142
108MP0001340_abnormal_eyelid_morphology0.94557779
109MP0001177_atelectasis0.94388177
110MP0003755_abnormal_palate_morphology0.94309553
111MP0003329_amyloid_beta_deposits0.94270333
112* MP0008569_lethality_at_weaning0.93460681
113MP0004858_abnormal_nervous_system0.92674623
114MP0009703_decreased_birth_body0.92645961
115MP0000049_abnormal_middle_ear0.92378096
116MP0006054_spinal_hemorrhage0.92198173
117MP0008961_abnormal_basal_metabolism0.90342600
118MP0005377_hearing/vestibular/ear_phenot0.88760158
119MP0003878_abnormal_ear_physiology0.88760158
120* MP0001944_abnormal_pancreas_morphology0.88486178
121MP0001529_abnormal_vocalization0.87331580
122MP0000534_abnormal_ureter_morphology0.86928757
123MP0002938_white_spotting0.86838628
124MP0002084_abnormal_developmental_patter0.86741463
125MP0000428_abnormal_craniofacial_morphol0.86718849
126MP0001501_abnormal_sleep_pattern0.86581196
127MP0000383_abnormal_hair_follicle0.86315469
128MP0009250_abnormal_appendicular_skeleto0.86249202
129MP0002736_abnormal_nociception_after0.85815770
130* MP0002066_abnormal_motor_capabilities/c0.85709230
131* MP0002081_perinatal_lethality0.85123485
132MP0000678_abnormal_parathyroid_gland0.84899243
133* MP0002080_prenatal_lethality0.84731761
134* MP0005248_abnormal_Harderian_gland0.84266546
135MP0005645_abnormal_hypothalamus_physiol0.82809682
136MP0003091_abnormal_cell_migration0.82712246
137MP0002116_abnormal_craniofacial_bone0.81718009
138MP0003045_fibrosis0.81572445
139MP0008770_decreased_survivor_rate0.81512259
140MP0002277_abnormal_respiratory_mucosa0.81267514
141MP0002796_impaired_skin_barrier0.81054368
142MP0002177_abnormal_outer_ear0.80779901
143MP0008007_abnormal_cellular_replicative0.80694356
144MP0001984_abnormal_olfaction0.80491870
145MP0003937_abnormal_limbs/digits/tail_de0.79956638
146MP0000566_synostosis0.78996451
147* MP0001188_hyperpigmentation0.78595577
148* MP0001943_abnormal_respiration0.77712282
149MP0001849_ear_inflammation0.77425487
150* MP0004197_abnormal_fetal_growth/weight/0.76724606
151MP0004484_altered_response_of0.76233236
152MP0010368_abnormal_lymphatic_system0.75500453
153MP0000163_abnormal_cartilage_morphology0.73770055
154* MP0003115_abnormal_respiratory_system0.72941709
155MP0000432_abnormal_head_morphology0.71532067
156MP0000733_abnormal_muscle_development0.70592625
157MP0004145_abnormal_muscle_electrophysio0.68433096
158* MP0002693_abnormal_pancreas_physiology0.67622780
159MP0000462_abnormal_digestive_system0.67589762
160MP0003315_abnormal_perineum_morphology0.67196465
161* MP0001286_abnormal_eye_development0.66715504

Predicted human phenotypes

RankGene SetZ-score
1Termporal pattern (HP:0011008)3.80746276
2Insidious onset (HP:0003587)3.80746276
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.54910046
4Papilledema (HP:0001085)3.40740272
5Epiphyseal dysplasia (HP:0002656)3.28644446
6Ankyloglossia (HP:0010296)3.15392832
7Cortical dysplasia (HP:0002539)3.14315887
8Septo-optic dysplasia (HP:0100842)3.06959222
9Action tremor (HP:0002345)2.92276137
10Abnormal hair whorl (HP:0010721)2.91228297
11Focal motor seizures (HP:0011153)2.87858644
12Macroorchidism (HP:0000053)2.81699679
13Abnormality of oral frenula (HP:0000190)2.77676615
14Abnormality of the labia minora (HP:0012880)2.73706857
15Atonic seizures (HP:0010819)2.72718079
16Visual hallucinations (HP:0002367)2.72122161
17Progressive cerebellar ataxia (HP:0002073)2.70076603
18Abnormal pancreas size (HP:0012094)2.69927933
19Esophageal atresia (HP:0002032)2.64756223
20Abnormality of the septum pellucidum (HP:0007375)2.62250170
21Epileptic encephalopathy (HP:0200134)2.60905366
22High anterior hairline (HP:0009890)2.52336922
23Abnormal lung lobation (HP:0002101)2.48987240
24Excessive salivation (HP:0003781)2.47627574
25Drooling (HP:0002307)2.47627574
26Focal seizures (HP:0007359)2.45675370
27Mild short stature (HP:0003502)2.43884227
28Genetic anticipation (HP:0003743)2.42141264
29Subacute progressive viral hepatitis (HP:0006572)2.39959591
30Nephroblastoma (Wilms tumor) (HP:0002667)2.36175508
31Absence seizures (HP:0002121)2.31898130
32Vitreoretinal degeneration (HP:0000655)2.30774807
33Buphthalmos (HP:0000557)2.27627261
34Embryonal renal neoplasm (HP:0011794)2.20569439
35Thyroid carcinoma (HP:0002890)2.17785141
36Abnormality of binocular vision (HP:0011514)2.17230888
37Diplopia (HP:0000651)2.17230888
38Absent septum pellucidum (HP:0001331)2.17155122
39Myelomeningocele (HP:0002475)2.15446682
40Broad-based gait (HP:0002136)2.15015089
41Hypoplastic ischia (HP:0003175)2.14208206
42Papillary thyroid carcinoma (HP:0002895)2.14168458
43Colon cancer (HP:0003003)2.12904573
44Volvulus (HP:0002580)2.12186419
45Deep philtrum (HP:0002002)2.11973455
46Absent frontal sinuses (HP:0002688)2.08924348
47Omphalocele (HP:0001539)2.08210531
48Stenosis of the external auditory canal (HP:0000402)2.06573222
49Myokymia (HP:0002411)2.06536589
50Lower limb asymmetry (HP:0100559)2.06165313
51Rhabdomyosarcoma (HP:0002859)2.05422405
52Labial hypoplasia (HP:0000066)2.03621354
53Pheochromocytoma (HP:0002666)2.01450911
54Gastrointestinal atresia (HP:0002589)2.01349040
55Agitation (HP:0000713)2.00248388
56Truncal ataxia (HP:0002078)1.99434641
57Calcaneovalgus deformity (HP:0001848)1.99008664
58Gastrointestinal carcinoma (HP:0002672)1.98741729
59Malignant gastrointestinal tract tumors (HP:0006749)1.98741729
60Exostoses (HP:0100777)1.98014544
61Postural tremor (HP:0002174)1.97806089
62Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95526329
63Aqueductal stenosis (HP:0002410)1.95381382
64Midline defect of the nose (HP:0004122)1.94610775
65Missing ribs (HP:0000921)1.94267949
66Hepatoblastoma (HP:0002884)1.93507442
67* Curly hair (HP:0002212)1.92115403
68* Transitional cell carcinoma of the bladder (HP:0006740)1.91665698
69Progressive sensorineural hearing impairment (HP:0000408)1.91220726
70Amblyopia (HP:0000646)1.90869744
71Optic nerve hypoplasia (HP:0000609)1.90353588
72Hypoplastic female external genitalia (HP:0012815)1.90259304
73Abnormality of the ischium (HP:0003174)1.90051016
74Depression (HP:0000716)1.89244435
75Cerebral inclusion bodies (HP:0100314)1.88777929
76Epileptiform EEG discharges (HP:0011182)1.88631153
77Bifid tongue (HP:0010297)1.88146392
78Enlarged epiphyses (HP:0010580)1.88003913
79Deformed tarsal bones (HP:0008119)1.87638679
80Aplasia/Hypoplasia of the sternum (HP:0006714)1.87433291
81Vertebral arch anomaly (HP:0008438)1.87296971
82Abnormality of calcium-phosphate metabolism (HP:0100530)1.86817801
83Oligodactyly (HP:0012165)1.84617135
84Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84407920
85Impaired smooth pursuit (HP:0007772)1.84325747
86Abnormality of chromosome stability (HP:0003220)1.84107949
87Amyotrophic lateral sclerosis (HP:0007354)1.83995462
88Oligodactyly (hands) (HP:0001180)1.83602753
89Inappropriate behavior (HP:0000719)1.83377850
90Dialeptic seizures (HP:0011146)1.83064410
91Shoulder girdle muscle weakness (HP:0003547)1.82799858
92Absent speech (HP:0001344)1.82501930
93Intestinal atresia (HP:0011100)1.82327492
942-3 toe syndactyly (HP:0004691)1.82066399
95Hyperventilation (HP:0002883)1.80671758
96EEG with generalized epileptiform discharges (HP:0011198)1.80326485
97Abnormal foot bone ossification (HP:0010675)1.79886239
98Abnormal tarsal ossification (HP:0008369)1.78530678
99Hypoplastic labia majora (HP:0000059)1.78497601
100Uterine leiomyosarcoma (HP:0002891)1.76864662
101Leiomyosarcoma (HP:0100243)1.76864662
102Maternal diabetes (HP:0009800)1.76817228
103Disinhibition (HP:0000734)1.76365007
104* Bladder neoplasm (HP:0009725)1.75754492
105* Bladder carcinoma (HP:0002862)1.75754492
106Lower limb amyotrophy (HP:0007210)1.75658719
107Ulnar claw (HP:0001178)1.75460044
108Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75372230
109Short middle phalanx of the 5th finger (HP:0004220)1.75267827
110Micropenis (HP:0000054)1.74489727
111Hip dysplasia (HP:0001385)1.74199653
112Erectile abnormalities (HP:0100639)1.73724686
113Increased nuchal translucency (HP:0010880)1.73523093
114Exotropia (HP:0000577)1.73483440
115Spinal cord compression (HP:0002176)1.73254427
116Hypsarrhythmia (HP:0002521)1.72614908
117Medulloblastoma (HP:0002885)1.71512196
118Irregular epiphyses (HP:0010582)1.70649198
119Cutaneous syndactyly (HP:0012725)1.70455957
120Overlapping toe (HP:0001845)1.70380138
121Bronchomalacia (HP:0002780)1.70177421
122Breast aplasia (HP:0100783)1.69532520
123Thin bony cortex (HP:0002753)1.68841878
124Open mouth (HP:0000194)1.68704086
125Broad thumb (HP:0011304)1.68243222
126Cutaneous finger syndactyly (HP:0010554)1.68111774
127Febrile seizures (HP:0002373)1.68103184
128Poor eye contact (HP:0000817)1.67515980
129Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67232354
130Short 4th metacarpal (HP:0010044)1.67232354
131Pelvic girdle muscle weakness (HP:0003749)1.66646149
132Neuroendocrine neoplasm (HP:0100634)1.66560379
133Spastic diplegia (HP:0001264)1.65932795
134Stereotypic behavior (HP:0000733)1.65827782
135Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.65611636
136Abnormality of the corticospinal tract (HP:0002492)1.65570911
137Impaired vibration sensation in the lower limbs (HP:0002166)1.65414639
138Abnormality of the astrocytes (HP:0100707)1.63864477
139Astrocytoma (HP:0009592)1.63864477
140Abnormality of the lower motor neuron (HP:0002366)1.63725759
141Arterial tortuosity (HP:0005116)1.63540685
142Hemivertebrae (HP:0002937)1.63198731
143Genital tract atresia (HP:0001827)1.62944386
144Neoplasm of the adrenal cortex (HP:0100641)1.62900183
145Intellectual disability, profound (HP:0002187)1.62413475
146Abnormality of nail color (HP:0100643)1.61214111
147Symptomatic seizures (HP:0011145)1.60795467
148Impaired social interactions (HP:0000735)1.60508099
149Abnormal social behavior (HP:0012433)1.60508099
150Supranuclear gaze palsy (HP:0000605)1.60321400
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59854821
152Anencephaly (HP:0002323)1.59576150
153Broad nasal tip (HP:0000455)1.59331238
154Small epiphyses (HP:0010585)1.59243495
155Spinal cord lesions (HP:0100561)1.59117017
156Syringomyelia (HP:0003396)1.59117017
157Vaginal atresia (HP:0000148)1.59007442
158Urinary urgency (HP:0000012)1.58863682
159Congenital glaucoma (HP:0001087)1.58617890
160Meningocele (HP:0002435)1.58317904
161Aplasia/Hypoplasia of the breasts (HP:0010311)1.57876272
162Anophthalmia (HP:0000528)1.57726278
163Wide intermamillary distance (HP:0006610)1.57023870
164Nuclear cataract (HP:0100018)1.56977346
165Hyperthyroidism (HP:0000836)1.56938595
166Obstructive sleep apnea (HP:0002870)1.56527052
167Abnormality of salivation (HP:0100755)1.56110120
168Broad alveolar ridges (HP:0000187)1.55918158
169Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.55770821
170Progressive hearing impairment (HP:0001730)1.55713946
171Primary amenorrhea (HP:0000786)1.55462463
172Limb dystonia (HP:0002451)1.55242695
173Neoplasm of the oral cavity (HP:0100649)1.54798247
174Asymmetry of the thorax (HP:0001555)1.54458714
175Pointed chin (HP:0000307)1.53943875
176* Pulmonic stenosis (HP:0001642)1.53943419
177Selective tooth agenesis (HP:0001592)1.53760749
178Broad foot (HP:0001769)1.53541546
179Shallow orbits (HP:0000586)1.53206316
180Neoplasm of the thyroid gland (HP:0100031)1.53017215
181Obsessive-compulsive behavior (HP:0000722)1.52971235
182Vertebral hypoplasia (HP:0008417)1.52970919
183Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.52970919
184Urinary bladder sphincter dysfunction (HP:0002839)1.51753533
185Absent eyelashes (HP:0000561)1.51604487
186Chorioretinal coloboma (HP:0000567)1.51159320
187Growth hormone deficiency (HP:0000824)1.51047405
188Abnormality of the antihelix (HP:0009738)1.50932146
189Abnormality of the musculature of the pelvis (HP:0001469)1.50453979
190Abnormality of the hip-girdle musculature (HP:0001445)1.50453979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.03870308
2NTRK33.65874640
3MARK13.11547439
4PRKD32.71421926
5MAP3K92.64525695
6TRIM282.64379442
7KSR12.55011868
8PLK22.25259174
9PNCK2.16827672
10SRPK12.16314764
11MINK12.13459553
12MAP3K22.11535068
13FRK2.08083206
14NTRK12.05653945
15MST42.05375225
16YES12.00958223
17EPHA41.96618062
18MAP3K41.93594935
19KSR21.82090548
20STK38L1.77495539
21MAP3K101.70609527
22STK31.70252871
23NTRK21.66587194
24PAK31.61302135
25TSSK61.60566856
26TYRO31.58502694
27RPS6KA41.55034105
28ERBB31.54041237
29EIF2AK31.49304070
30TAF11.47170169
31LATS11.47003101
32DYRK21.45228624
33STK161.44732651
34SCYL21.42718331
35EPHB21.39710208
36CAMK1G1.37545235
37NLK1.36448257
38UHMK11.35078172
39ALK1.34152252
40CSNK1G21.34092923
41PAK61.32377809
42PBK1.30166923
43RET1.29523882
44LATS21.28353847
45TTK1.28035747
46DYRK31.24815090
47PDGFRA1.22060470
48CDK51.18861280
49CAMKK11.18467412
50CSNK1A1L1.16097970
51BCR1.15456826
52FGFR21.11636115
53SIK21.11336308
54FER1.11074252
55NUAK11.06296413
56PTK21.05192787
57PRKCH1.03138928
58STK391.03035453
59FGFR11.00527830
60BRSK21.00386087
61RIPK10.98091723
62CDK140.97512403
63CDK60.94619180
64WNK10.92270066
65HIPK20.90624444
66PDGFRB0.89824093
67MAP2K70.88872615
68DYRK1A0.88797649
69MAP2K40.87293282
70DMPK0.87134668
71CDC70.87091538
72NEK20.86581568
73BMPR1B0.86083361
74CDK180.85406101
75BRD40.84883007
76WNK30.81939321
77MKNK20.81345211
78DDR20.80304020
79PLK40.79623342
80BUB10.79189606
81CDK150.78902637
82DAPK20.78841446
83PTK60.78572755
84STK110.78377875
85ERBB40.77067973
86NEK10.75035999
87PKN20.74946969
88WEE10.73716343
89OXSR10.72220132
90MELK0.71590770
91CSNK1G30.70594837
92MET0.70299741
93EIF2AK10.69296591
94CDK120.68900676
95MAPK130.68538137
96CDK11A0.68529334
97CAMK2B0.67794390
98SGK10.65459255
99FGFR30.65115363
100PLK30.64497415
101PASK0.64345589
102RIPK40.63813967
103CAMKK20.63363130
104SGK30.61591578
105MKNK10.60579805
106MOS0.60030537
107MAP3K10.59097265
108SIK30.58329337
109ROCK20.57753980
110ATM0.57685329
111PRKCG0.57175217
112EIF2AK20.56744641
113MAPK100.56428129
114CAMK1D0.56415591
115MAP3K120.56195226
116WNK40.55166688
117STK240.54220450
118CASK0.51579498
119PLK10.51545899
120CAMK2A0.50980423
121CDC42BPA0.48451928
122CSNK1E0.47967623
123GRK50.47743927
124NME10.47131695
125INSRR0.47019400
126EGFR0.46430931
127CDK30.45107076
128SGK20.44637337
129FES0.44488786
130NEK90.44188311
131INSR0.44130523
132CDK190.43970945
133FYN0.42972716
134FGR0.42243815
135TAOK10.42010431
136ICK0.40838430
137CSNK1G10.40724622
138SGK2230.40169078
139SGK4940.40169078
140PTK2B0.39746665
141CHEK10.38513901
142RAF10.38410196
143PRKCE0.36363998
144FLT30.34695229
145AKT30.34266847
146ATR0.33149247
147MAP3K140.32428597
148RPS6KB10.32271895

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.99004060
2mRNA surveillance pathway_Homo sapiens_hsa030152.57715851
3* Long-term potentiation_Homo sapiens_hsa047202.44569239
4Spliceosome_Homo sapiens_hsa030402.34579023
5RNA transport_Homo sapiens_hsa030132.30584193
6RNA degradation_Homo sapiens_hsa030182.17010748
7Cell cycle_Homo sapiens_hsa041102.15234891
8Basal transcription factors_Homo sapiens_hsa030222.06277374
9Non-homologous end-joining_Homo sapiens_hsa034502.05035363
10Nicotine addiction_Homo sapiens_hsa050332.00120796
11Amphetamine addiction_Homo sapiens_hsa050311.95661438
12Dopaminergic synapse_Homo sapiens_hsa047281.93298755
13Circadian entrainment_Homo sapiens_hsa047131.93172238
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.85552925
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82958409
16Insulin secretion_Homo sapiens_hsa049111.79891678
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77389357
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.74226238
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.74119867
20Glutamatergic synapse_Homo sapiens_hsa047241.71935705
21GABAergic synapse_Homo sapiens_hsa047271.65259664
22Synaptic vesicle cycle_Homo sapiens_hsa047211.61444480
23Olfactory transduction_Homo sapiens_hsa047401.59110209
24Morphine addiction_Homo sapiens_hsa050321.58047741
25* Axon guidance_Homo sapiens_hsa043601.54153299
26* Long-term depression_Homo sapiens_hsa047301.53611693
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.53236979
28* Cholinergic synapse_Homo sapiens_hsa047251.49579331
29Cocaine addiction_Homo sapiens_hsa050301.49423815
30* Glioma_Homo sapiens_hsa052141.49041887
31Renin secretion_Homo sapiens_hsa049241.46918374
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46915376
33Salivary secretion_Homo sapiens_hsa049701.46436360
34* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44652723
35Steroid biosynthesis_Homo sapiens_hsa001001.43918747
36* Estrogen signaling pathway_Homo sapiens_hsa049151.43147121
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39369757
38Gastric acid secretion_Homo sapiens_hsa049711.38922907
39* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33292212
40* Gap junction_Homo sapiens_hsa045401.32356479
41p53 signaling pathway_Homo sapiens_hsa041151.31788643
42* Renal cell carcinoma_Homo sapiens_hsa052111.31537770
43* Dorso-ventral axis formation_Homo sapiens_hsa043201.30932528
44* Oxytocin signaling pathway_Homo sapiens_hsa049211.28743491
45Type II diabetes mellitus_Homo sapiens_hsa049301.27335265
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.25971483
47* Serotonergic synapse_Homo sapiens_hsa047261.25763888
48* ErbB signaling pathway_Homo sapiens_hsa040121.25746673
49Mismatch repair_Homo sapiens_hsa034301.22552503
50* Melanogenesis_Homo sapiens_hsa049161.22212331
51* GnRH signaling pathway_Homo sapiens_hsa049121.21580345
52mTOR signaling pathway_Homo sapiens_hsa041501.16154862
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14418340
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14292647
55* Endometrial cancer_Homo sapiens_hsa052131.14199343
56Adherens junction_Homo sapiens_hsa045201.13293581
57* Colorectal cancer_Homo sapiens_hsa052101.08383981
58* Neurotrophin signaling pathway_Homo sapiens_hsa047221.08260863
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06880249
60Taste transduction_Homo sapiens_hsa047421.06694654
61Phototransduction_Homo sapiens_hsa047441.06192856
62cAMP signaling pathway_Homo sapiens_hsa040241.06148202
63cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05954143
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05525028
65Selenocompound metabolism_Homo sapiens_hsa004501.03939461
66Wnt signaling pathway_Homo sapiens_hsa043101.03688186
67Oocyte meiosis_Homo sapiens_hsa041141.01954597
68Hippo signaling pathway_Homo sapiens_hsa043900.99108468
69* VEGF signaling pathway_Homo sapiens_hsa043700.96876976
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95567977
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.95307222
72Thyroid hormone synthesis_Homo sapiens_hsa049180.92996527
73* Chronic myeloid leukemia_Homo sapiens_hsa052200.92893771
74Nucleotide excision repair_Homo sapiens_hsa034200.92745679
75* Proteoglycans in cancer_Homo sapiens_hsa052050.89787904
76Focal adhesion_Homo sapiens_hsa045100.89120625
77* MAPK signaling pathway_Homo sapiens_hsa040100.88706906
78* Choline metabolism in cancer_Homo sapiens_hsa052310.86306463
79* Non-small cell lung cancer_Homo sapiens_hsa052230.86304346
80* Rap1 signaling pathway_Homo sapiens_hsa040150.86261574
81* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86108763
82* Ras signaling pathway_Homo sapiens_hsa040140.84736673
83DNA replication_Homo sapiens_hsa030300.84205156
84* Pathways in cancer_Homo sapiens_hsa052000.83991603
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83729466
86* MicroRNAs in cancer_Homo sapiens_hsa052060.80911332
87Proteasome_Homo sapiens_hsa030500.80598195
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80488292
89* T cell receptor signaling pathway_Homo sapiens_hsa046600.80345754
90* Phospholipase D signaling pathway_Homo sapiens_hsa040720.79725183
91TGF-beta signaling pathway_Homo sapiens_hsa043500.79252490
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78208622
93Hedgehog signaling pathway_Homo sapiens_hsa043400.77891132
94* Pancreatic cancer_Homo sapiens_hsa052120.77196622
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77187679
96Vibrio cholerae infection_Homo sapiens_hsa051100.77036735
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76760016
98* Tight junction_Homo sapiens_hsa045300.76084940
99Glucagon signaling pathway_Homo sapiens_hsa049220.73781217
100Fanconi anemia pathway_Homo sapiens_hsa034600.72926073
101* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72044499
102Notch signaling pathway_Homo sapiens_hsa043300.71864436
103RNA polymerase_Homo sapiens_hsa030200.70942275
104Pancreatic secretion_Homo sapiens_hsa049720.70717559
105* Sphingolipid signaling pathway_Homo sapiens_hsa040710.70194243
106Calcium signaling pathway_Homo sapiens_hsa040200.70040294
107Endocytosis_Homo sapiens_hsa041440.69409539
108Type I diabetes mellitus_Homo sapiens_hsa049400.69256566
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.69154238
110* Prostate cancer_Homo sapiens_hsa052150.68981572
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67606545
112Small cell lung cancer_Homo sapiens_hsa052220.67289316
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66090900
114* Prolactin signaling pathway_Homo sapiens_hsa049170.65301882
115Shigellosis_Homo sapiens_hsa051310.65089221
116* FoxO signaling pathway_Homo sapiens_hsa040680.64122985
117* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64098856
118* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63770543
119* Thyroid cancer_Homo sapiens_hsa052160.63160881
120Dilated cardiomyopathy_Homo sapiens_hsa054140.62563978
121* Melanoma_Homo sapiens_hsa052180.62394222
122Inositol phosphate metabolism_Homo sapiens_hsa005620.61261657
123* Bladder cancer_Homo sapiens_hsa052190.61178671
124Platelet activation_Homo sapiens_hsa046110.60721788
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60607331
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59331868
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59213569
128* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58422190
129* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58056629
130Basal cell carcinoma_Homo sapiens_hsa052170.57639387
131Homologous recombination_Homo sapiens_hsa034400.55785837
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55254784
133Propanoate metabolism_Homo sapiens_hsa006400.52762780
134One carbon pool by folate_Homo sapiens_hsa006700.52467565
135* Central carbon metabolism in cancer_Homo sapiens_hsa052300.52110692
136* Hepatitis B_Homo sapiens_hsa051610.51401436
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.48259538
138Circadian rhythm_Homo sapiens_hsa047100.47292886
139Measles_Homo sapiens_hsa051620.46308572
140Epstein-Barr virus infection_Homo sapiens_hsa051690.45880023
141HIF-1 signaling pathway_Homo sapiens_hsa040660.43382172
142Salmonella infection_Homo sapiens_hsa051320.39632292
143Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39024012
144* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38071363
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33995165

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