KRASP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1type B pancreatic cell development (GO:0003323)9.58216038
2cerebellar Purkinje cell layer development (GO:0021680)6.67934348
3glandular epithelial cell development (GO:0002068)6.64114985
4epithelial cell maturation (GO:0002070)6.61447756
5regulation of transcription involved in cell fate commitment (GO:0060850)5.92661450
6oligodendrocyte differentiation (GO:0048709)5.82000988
7synaptic transmission, cholinergic (GO:0007271)5.56856278
8response to histamine (GO:0034776)5.25752555
9neurofilament cytoskeleton organization (GO:0060052)5.25315918
10columnar/cuboidal epithelial cell development (GO:0002066)5.21093088
11negative regulation of glial cell differentiation (GO:0045686)4.94459847
12pancreas development (GO:0031016)4.94033179
13positive regulation of vesicle fusion (GO:0031340)4.89798157
14phosphorelay signal transduction system (GO:0000160)4.80234214
15endoderm formation (GO:0001706)4.80105898
16short-term memory (GO:0007614)4.72477797
17inner ear receptor cell development (GO:0060119)4.70281062
18L-serine metabolic process (GO:0006563)4.69681077
19toxin metabolic process (GO:0009404)4.68117424
20positive regulation of glial cell differentiation (GO:0045687)4.60805934
21negative regulation of translation, ncRNA-mediated (GO:0040033)4.59971213
22regulation of translation, ncRNA-mediated (GO:0045974)4.59971213
23negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.59971213
24ganglion development (GO:0061548)4.44480230
25positive regulation of neurological system process (GO:0031646)4.42855341
26epithelial cell differentiation involved in kidney development (GO:0035850)4.38715652
27regulation of gene silencing by miRNA (GO:0060964)4.33755021
28regulation of gene silencing by RNA (GO:0060966)4.33755021
29regulation of posttranscriptional gene silencing (GO:0060147)4.33755021
30nephron tubule morphogenesis (GO:0072078)4.29210044
31nephron epithelium morphogenesis (GO:0072088)4.29210044
32regulation of neuron migration (GO:2001222)4.28583802
33spinal cord motor neuron differentiation (GO:0021522)4.27386476
34negative regulation of gliogenesis (GO:0014014)4.24423405
35inner ear receptor stereocilium organization (GO:0060122)4.11077777
36spinal cord association neuron differentiation (GO:0021527)3.93200980
37forebrain neuron differentiation (GO:0021879)3.91967340
38protein localization to cilium (GO:0061512)3.89592487
39nonmotile primary cilium assembly (GO:0035058)3.81874456
40head development (GO:0060322)3.79731696
41mitochondrial calcium ion transport (GO:0006851)3.78025018
42dorsal/ventral neural tube patterning (GO:0021904)3.73790080
43endocrine pancreas development (GO:0031018)3.65388356
44mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63134989
45epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.62213881
46regulation of ARF protein signal transduction (GO:0032012)3.56258442
47dendrite development (GO:0016358)3.56015584
48positive regulation of gliogenesis (GO:0014015)3.55285824
49intestinal epithelial cell development (GO:0060576)3.55228847
50cellular response to ammonium ion (GO:0071242)3.49747270
51regulation of cell fate specification (GO:0042659)3.46998845
52preassembly of GPI anchor in ER membrane (GO:0016254)3.39247860
53cerebral cortex neuron differentiation (GO:0021895)3.38906741
54heart valve formation (GO:0003188)3.33023053
55gamma-aminobutyric acid signaling pathway (GO:0007214)3.32328961
56positive regulation of prostaglandin secretion (GO:0032308)3.32022212
57transmission of nerve impulse (GO:0019226)3.31827113
58positive regulation of synapse maturation (GO:0090129)3.31243540
59positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.29193135
60regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.29193135
61positive regulation of muscle cell apoptotic process (GO:0010661)3.28761816
62ATP synthesis coupled proton transport (GO:0015986)3.27304528
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.27304528
64response to nicotine (GO:0035094)3.26752137
65cardiac septum development (GO:0003279)3.24913878
66regulation of prostaglandin secretion (GO:0032306)3.21546579
67renal tubule morphogenesis (GO:0061333)3.19700666
68cornea development in camera-type eye (GO:0061303)3.14305448
69detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12679065
70positive regulation of antigen processing and presentation (GO:0002579)3.04697440
71positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.03424527
72regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.03424527
73vesicle transport along microtubule (GO:0047496)2.99549152
74ventricular septum development (GO:0003281)2.98282404
75activation of protein kinase A activity (GO:0034199)2.97527183
76smoothened signaling pathway (GO:0007224)2.95218381
77myoblast fusion (GO:0007520)2.91480196
78vocalization behavior (GO:0071625)2.89250012
79histone H3-K4 trimethylation (GO:0080182)2.89166065
80positive regulation of amino acid transport (GO:0051957)2.85660649
81intermediate filament organization (GO:0045109)2.85202790
82positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.82241347
83viral protein processing (GO:0019082)2.82034283
84negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80715441
85positive regulation of T-helper 1 type immune response (GO:0002827)2.80138041
86positive regulation of protein depolymerization (GO:1901881)2.79844348
87protein insertion into membrane (GO:0051205)2.77450963
88phosphatidylinositol 3-kinase signaling (GO:0014065)2.76973976
89axon development (GO:0061564)2.75536101
90negative regulation of osteoblast proliferation (GO:0033689)2.75536054
91opioid receptor signaling pathway (GO:0038003)2.73078931
92behavioral response to nicotine (GO:0035095)2.72718917
93negative regulation of cardiac muscle hypertrophy (GO:0010614)2.67207946
94regulation of synapse maturation (GO:0090128)2.66946687
95lateral sprouting from an epithelium (GO:0060601)2.64622617
96positive regulation of dendritic spine morphogenesis (GO:0061003)2.63561013
97regulation of glial cell differentiation (GO:0045685)2.61848042
98neuromuscular synaptic transmission (GO:0007274)2.61507229
99neuronal action potential propagation (GO:0019227)2.60822317
100cell differentiation in spinal cord (GO:0021515)2.60077575

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.98900142
2TAF15_26573619_Chip-Seq_HEK293_Human4.95945828
3ZNF274_21170338_ChIP-Seq_K562_Hela3.74193949
4GBX2_23144817_ChIP-Seq_PC3_Human3.61059592
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.58922351
6RNF2_27304074_Chip-Seq_NSC_Mouse3.27270743
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.88020108
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.67182200
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.60151764
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.45422655
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38208746
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.35656440
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.20447529
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.20036208
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.15416081
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15250530
17REST_21632747_ChIP-Seq_MESCs_Mouse2.11627611
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00671751
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95140682
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88695203
21JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84919591
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.83034124
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.81551830
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80454648
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80131327
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.74122092
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72309772
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70591221
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69158724
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68874646
31SMAD4_21799915_ChIP-Seq_A2780_Human1.66558473
32P300_19829295_ChIP-Seq_ESCs_Human1.65200822
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61517886
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60784336
35MYC_18940864_ChIP-ChIP_HL60_Human1.60420728
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60092252
37MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.59624492
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59394439
39EWS_26573619_Chip-Seq_HEK293_Human1.56039653
40KDM2B_26808549_Chip-Seq_REH_Human1.54100411
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.53433068
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49555244
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49517874
44CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47013531
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.46084423
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43667121
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43258312
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43258312
49ER_23166858_ChIP-Seq_MCF-7_Human1.41708218
50FUS_26573619_Chip-Seq_HEK293_Human1.41298483
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.37877236
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37468063
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35582450
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.30800895
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30638537
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30427603
57VDR_22108803_ChIP-Seq_LS180_Human1.30416823
58BCAT_22108803_ChIP-Seq_LS180_Human1.30161677
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29838643
60TAL1_26923725_Chip-Seq_HPCs_Mouse1.28683570
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27852858
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.27632492
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.26915359
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.26161280
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24207844
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.22921448
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.22789882
68TBX3_20139965_ChIP-Seq_MESCs_Mouse1.22079508
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20992768
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19692509
71AR_25329375_ChIP-Seq_VCAP_Human1.17564866
72REST_19997604_ChIP-ChIP_NEURONS_Mouse1.16198839
73STAT3_23295773_ChIP-Seq_U87_Human1.15872471
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14859503
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13413045
76CBP_20019798_ChIP-Seq_JUKART_Human1.12635714
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12635714
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.12433747
79SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10569821
80E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08362138
81P53_22387025_ChIP-Seq_ESCs_Mouse1.08228192
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.07206670
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.07206670
84LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03662953
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02956248
86RXR_22108803_ChIP-Seq_LS180_Human1.01618153
87STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99822031
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.99248965
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99167691
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97846819
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97023769
92NFYA_21822215_ChIP-Seq_K562_Human0.95715799
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94888919
94TBL1_22424771_ChIP-Seq_293T_Human0.94061217
95AR_19668381_ChIP-Seq_PC3_Human0.93292776
96TCF4_23295773_ChIP-Seq_U87_Human0.93050728
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92305410
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91889838
99SOX9_26525672_Chip-Seq_HEART_Mouse0.89772794
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89483035

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005248_abnormal_Harderian_gland5.09669187
2MP0008875_abnormal_xenobiotic_pharmacok3.86837656
3MP0001346_abnormal_lacrimal_gland3.59762832
4MP0006072_abnormal_retinal_apoptosis3.59592714
5MP0004133_heterotaxia3.35009900
6MP0003879_abnormal_hair_cell2.84721697
7MP0004885_abnormal_endolymph2.80702195
8MP0002653_abnormal_ependyma_morphology2.79357287
9MP0001188_hyperpigmentation2.68723864
10MP0004145_abnormal_muscle_electrophysio2.63452745
11MP0008877_abnormal_DNA_methylation2.50917117
12MP0003787_abnormal_imprinting2.47005660
13MP0002735_abnormal_chemical_nociception2.38529193
14MP0000955_abnormal_spinal_cord2.32988513
15MP0004147_increased_porphyrin_level2.29086479
16MP0001486_abnormal_startle_reflex2.21146845
17MP0003890_abnormal_embryonic-extraembry2.15144802
18MP0009046_muscle_twitch2.10539810
19MP0000778_abnormal_nervous_system2.05122953
20MP0002009_preneoplasia1.93639230
21MP0004043_abnormal_pH_regulation1.85514682
22MP0001299_abnormal_eye_distance/1.85338691
23MP0005253_abnormal_eye_physiology1.83147734
24MP0000631_abnormal_neuroendocrine_gland1.82982573
25MP0001984_abnormal_olfaction1.82290089
26MP0000026_abnormal_inner_ear1.81124695
27MP0002184_abnormal_innervation1.75905758
28MP0002272_abnormal_nervous_system1.75797217
29MP0003938_abnormal_ear_development1.72107161
30MP0009379_abnormal_foot_pigmentation1.61062458
31MP0002736_abnormal_nociception_after1.60803733
32MP0009745_abnormal_behavioral_response1.57679039
33MP0003941_abnormal_skin_development1.47354008
34MP0002752_abnormal_somatic_nervous1.47098961
35MP0005423_abnormal_somatic_nervous1.45904596
36MP0000647_abnormal_sebaceous_gland1.45449942
37MP0003755_abnormal_palate_morphology1.42116890
38MP0001286_abnormal_eye_development1.38928910
39MP0004782_abnormal_surfactant_physiolog1.34990299
40MP0005551_abnormal_eye_electrophysiolog1.33950445
41MP0003635_abnormal_synaptic_transmissio1.30522051
42MP0001963_abnormal_hearing_physiology1.30260625
43MP0009250_abnormal_appendicular_skeleto1.29976572
44MP0003567_abnormal_fetal_cardiomyocyte1.29746367
45MP0003385_abnormal_body_wall1.29117272
46MP0004215_abnormal_myocardial_fiber1.27648736
47MP0005394_taste/olfaction_phenotype1.26820299
48MP0005499_abnormal_olfactory_system1.26820299
49MP0003718_maternal_effect1.21960616
50MP0002138_abnormal_hepatobiliary_system1.21681823
51MP0005195_abnormal_posterior_eye1.19436617
52MP0006292_abnormal_olfactory_placode1.16861356
53MP0003121_genomic_imprinting1.15404462
54MP0002882_abnormal_neuron_morphology1.15041644
55MP0002557_abnormal_social/conspecific_i1.14275097
56MP0004742_abnormal_vestibular_system1.14169720
57MP0002234_abnormal_pharynx_morphology1.13443553
58MP0002697_abnormal_eye_size1.10235817
59MP0001968_abnormal_touch/_nociception1.08310302
60MP0002572_abnormal_emotion/affect_behav1.07867273
61MP0003937_abnormal_limbs/digits/tail_de1.06841222
62MP0005083_abnormal_biliary_tract1.05546237
63MP0002909_abnormal_adrenal_gland1.05143698
64MP0003935_abnormal_craniofacial_develop1.04968823
65MP0000049_abnormal_middle_ear1.03966725
66MP0001440_abnormal_grooming_behavior1.01777728
67MP0005386_behavior/neurological_phenoty0.99857475
68MP0004924_abnormal_behavior0.99857475
69MP0002932_abnormal_joint_morphology0.97945881
70MP0003329_amyloid_beta_deposits0.97179487
71MP0002132_abnormal_respiratory_system0.97034613
72MP0002277_abnormal_respiratory_mucosa0.95895044
73MP0001324_abnormal_eye_pigmentation0.95727255
74MP0002067_abnormal_sensory_capabilities0.94575306
75MP0004142_abnormal_muscle_tone0.93545105
76MP0002734_abnormal_mechanical_nocicepti0.93278469
77MP0003119_abnormal_digestive_system0.92723904
78MP0003880_abnormal_central_pattern0.91710313
79MP0008995_early_reproductive_senescence0.91637774
80MP0003122_maternal_imprinting0.90605460
81MP0002102_abnormal_ear_morphology0.89512533
82MP0001501_abnormal_sleep_pattern0.89179939
83MP0000372_irregular_coat_pigmentation0.88623352
84MP0005084_abnormal_gallbladder_morpholo0.88450412
85MP0003115_abnormal_respiratory_system0.87735197
86MP0001986_abnormal_taste_sensitivity0.85939320
87MP0002152_abnormal_brain_morphology0.84658099
88MP0000613_abnormal_salivary_gland0.84504394
89MP0002233_abnormal_nose_morphology0.84497667
90MP0004084_abnormal_cardiac_muscle0.84048730
91MP0001485_abnormal_pinna_reflex0.84027143
92MP0002064_seizures0.83334979
93MP0004130_abnormal_muscle_cell0.82593748
94MP0003861_abnormal_nervous_system0.82089734
95MP0001340_abnormal_eyelid_morphology0.79790819
96MP0002751_abnormal_autonomic_nervous0.78981905
97MP0002693_abnormal_pancreas_physiology0.77694136
98MP0001944_abnormal_pancreas_morphology0.77268096
99MP0008789_abnormal_olfactory_epithelium0.76686091
100MP0002063_abnormal_learning/memory/cond0.75702302

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.72363156
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.72363156
3Abnormality of the corticospinal tract (HP:0002492)5.21029351
4Papilledema (HP:0001085)4.98006601
5Urinary urgency (HP:0000012)4.58946934
6Insidious onset (HP:0003587)4.49481605
7Termporal pattern (HP:0011008)4.49481605
8Septo-optic dysplasia (HP:0100842)4.42202983
9Overlapping toe (HP:0001845)4.01828327
10Acute necrotizing encephalopathy (HP:0006965)3.93793723
11Calcaneovalgus deformity (HP:0001848)3.59182726
12Absent septum pellucidum (HP:0001331)3.58281571
13Adrenal hypoplasia (HP:0000835)3.57613039
14Hemiparesis (HP:0001269)3.53454867
15Medial flaring of the eyebrow (HP:0010747)3.40817048
16Abnormal mitochondria in muscle tissue (HP:0008316)3.35484846
17Deformed tarsal bones (HP:0008119)3.33642058
18Progressive macrocephaly (HP:0004481)3.28354117
19Gait imbalance (HP:0002141)3.21639603
20Colon cancer (HP:0003003)3.19028762
21Impaired vibration sensation in the lower limbs (HP:0002166)3.06660617
22Diastasis recti (HP:0001540)3.04395391
23Urinary bladder sphincter dysfunction (HP:0002839)3.03676901
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.03143839
25Congenital primary aphakia (HP:0007707)3.02425846
26Ulnar claw (HP:0001178)2.85049426
27Atonic seizures (HP:0010819)2.83538506
28Acute encephalopathy (HP:0006846)2.83536795
29Nephrogenic diabetes insipidus (HP:0009806)2.83376488
30Abnormality of the septum pellucidum (HP:0007375)2.83170260
31Breast hypoplasia (HP:0003187)2.78364117
32Lower limb muscle weakness (HP:0007340)2.76740465
33Paraplegia (HP:0010550)2.68770367
34Neoplasm of the tracheobronchial system (HP:0100552)2.60932459
35Cortical dysplasia (HP:0002539)2.45977026
36Abnormal respiratory motile cilium physiology (HP:0012261)2.41881379
37Supernumerary spleens (HP:0009799)2.38238094
38Ankle clonus (HP:0011448)2.36364299
39Coarctation of aorta (HP:0001680)2.35711475
40Abnormality of the fetal cardiovascular system (HP:0010948)2.32823810
41Abnormal umbilical cord blood vessels (HP:0011403)2.32823810
42Single umbilical artery (HP:0001195)2.32823810
43Hypoplastic left heart (HP:0004383)2.31189868
44True hermaphroditism (HP:0010459)2.30992162
45Absent/shortened dynein arms (HP:0200106)2.27731333
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.27731333
47Spastic paraplegia (HP:0001258)2.27450898
48Proximal amyotrophy (HP:0007126)2.24876719
49Poor coordination (HP:0002370)2.23637581
50Spinal muscular atrophy (HP:0007269)2.23524207
51Nephronophthisis (HP:0000090)2.22664669
52Abnormality of midbrain morphology (HP:0002418)2.18516137
53Molar tooth sign on MRI (HP:0002419)2.18516137
54Abnormality of the calcaneus (HP:0008364)2.17663089
553-Methylglutaconic aciduria (HP:0003535)2.17435652
56Shawl scrotum (HP:0000049)2.17183376
57Broad foot (HP:0001769)2.16348631
58Focal seizures (HP:0007359)2.14986172
59Febrile seizures (HP:0002373)2.14806507
60Morphological abnormality of the pyramidal tract (HP:0002062)2.10376133
61Vaginal atresia (HP:0000148)2.08158338
62Hypoplastic iliac wings (HP:0002866)2.07838865
63Spastic gait (HP:0002064)2.07306298
64Mitochondrial inheritance (HP:0001427)2.06332483
65Cerebral edema (HP:0002181)2.04981890
66Optic nerve hypoplasia (HP:0000609)2.02669426
67Growth hormone deficiency (HP:0000824)1.99384881
68Coronal craniosynostosis (HP:0004440)1.98169677
69Chin dimple (HP:0010751)1.97522374
70Hyperinsulinemic hypoglycemia (HP:0000825)1.94474234
71Genital tract atresia (HP:0001827)1.94276834
72Pancreatic fibrosis (HP:0100732)1.91604769
73Congenital, generalized hypertrichosis (HP:0004540)1.90412261
74Hypoplastic heart (HP:0001961)1.89974369
75Chronic bronchitis (HP:0004469)1.89659707
76Frequent falls (HP:0002359)1.86392927
77Genetic anticipation (HP:0003743)1.86088957
78Pterygium (HP:0001059)1.85145160
79Abnormality of the umbilical cord (HP:0010881)1.82481349
80Focal motor seizures (HP:0011153)1.81677318
81Woolly hair (HP:0002224)1.80963638
82Abnormality of homocysteine metabolism (HP:0010919)1.79275271
83Homocystinuria (HP:0002156)1.79275271
84Abnormality of the vocal cords (HP:0008777)1.79237488
85Abnormality of the fingertips (HP:0001211)1.78729733
86Abnormality of cells of the erythroid lineage (HP:0012130)1.78154881
87Abnormality of the renal medulla (HP:0100957)1.74930681
88Pachygyria (HP:0001302)1.72931524
89Hemiplegia (HP:0002301)1.70855849
90Biliary tract neoplasm (HP:0100574)1.70285802
91Exotropia (HP:0000577)1.70272876
92Absence seizures (HP:0002121)1.68522725
93Down-sloping shoulders (HP:0200021)1.68263217
94Asymmetric growth (HP:0100555)1.67608335
95Volvulus (HP:0002580)1.67475586
96Occipital encephalocele (HP:0002085)1.66918650
97Increased CSF lactate (HP:0002490)1.65645036
98Hypoplastic labia majora (HP:0000059)1.64828386
99Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.64801849
100Neoplasm of head and neck (HP:0012288)1.63697001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK19.31008645
2NME14.72420952
3DYRK1B3.93238572
4IRAK33.60017023
5WNK33.52673849
6PINK12.78480056
7EPHB22.60040031
8ICK2.54424721
9MAP3K42.38403722
10TNIK2.16626344
11ADRBK21.98554602
12STK111.85116275
13TAF11.81821418
14MARK11.81270917
15FRK1.74999490
16LATS21.67682535
17UHMK11.53991313
18TYRO31.41088530
19LIMK11.40546673
20MARK21.32233394
21MAP2K21.30513366
22MKNK21.30043270
23NTRK21.29799782
24NLK1.26222674
25NEK21.12335899
26CDK31.08970074
27MINK11.07980034
28MAP4K21.05596116
29YES11.04935755
30PHKG11.02459885
31PHKG21.02459885
32CDK191.00783677
33DYRK20.98913697
34MKNK10.96765324
35CAMK2A0.88681030
36NTRK10.88416901
37VRK20.84207991
38BCR0.83120288
39SGK10.80386227
40SGK20.77586922
41CDK80.71394392
42EIF2AK30.70146808
43MAPK120.69396244
44MAP3K60.69139543
45CDK90.66815912
46PRKG10.65345422
47WNK10.64537792
48TIE10.59421267
49OXSR10.58581817
50RPS6KA40.56067177
51CSNK1E0.51662135
52CDK60.51203091
53SIK20.48100247
54EIF2AK10.48020857
55DYRK30.46587782
56SGK2230.45456665
57SGK4940.45456665
58NEK60.44478986
59TAOK30.43666445
60WNK40.43207654
61NUAK10.40477992
62PRKCG0.39868491
63MAPK130.36723300
64RPS6KL10.36079574
65RPS6KC10.36079574
66CAMK10.35989053
67RPS6KA60.35637381
68DDR20.34877263
69VRK10.34034997
70CDK50.33947333
71MAPK40.33672277
72DYRK1A0.32338957
73MAPK90.31805809
74PDGFRA0.31284547
75MAP3K70.31242360
76CDK70.30869086
77ITK0.30036308
78TESK10.29872901
79MELK0.27344162
80SGK30.26690343
81BMPR1B0.26502740
82RPS6KA30.26424779
83TRIM280.25861063
84CDK140.24853461
85TSSK60.24391561
86SIK30.23791655
87OBSCN0.23762340
88CSNK1A10.23455507
89PRKACA0.23422969
90CHUK0.23061036
91PIM10.22796551
92MAP2K70.21001688
93TGFBR10.20859424
94FYN0.18987946
95CAMKK20.18549714
96INSRR0.17444543
97AURKB0.17248521
98PRKD10.17038470
99PRKAA10.16616072
100CAMK2D0.15308649

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.34550862
2Nicotine addiction_Homo sapiens_hsa050333.34481113
3Oxidative phosphorylation_Homo sapiens_hsa001903.25605600
4Protein export_Homo sapiens_hsa030602.97926828
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.95118740
6Dorso-ventral axis formation_Homo sapiens_hsa043202.81174036
7Sulfur metabolism_Homo sapiens_hsa009202.66688487
8Cardiac muscle contraction_Homo sapiens_hsa042602.60282551
9Parkinsons disease_Homo sapiens_hsa050122.42422826
10Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.29972373
11GABAergic synapse_Homo sapiens_hsa047272.16956792
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90469915
13Morphine addiction_Homo sapiens_hsa050321.88104664
14Alzheimers disease_Homo sapiens_hsa050101.78402006
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75486815
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.71179841
17Huntingtons disease_Homo sapiens_hsa050161.68008321
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67803383
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.63269220
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59025598
21Ribosome_Homo sapiens_hsa030101.51504805
22Basal transcription factors_Homo sapiens_hsa030221.46891436
23Collecting duct acid secretion_Homo sapiens_hsa049661.43929517
24Phototransduction_Homo sapiens_hsa047441.33596420
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24562698
26Taste transduction_Homo sapiens_hsa047421.22057591
27Linoleic acid metabolism_Homo sapiens_hsa005911.13685300
28Glutamatergic synapse_Homo sapiens_hsa047241.12773204
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.11631591
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05285870
31Fat digestion and absorption_Homo sapiens_hsa049751.04165971
32Phagosome_Homo sapiens_hsa041451.03873534
33Ovarian steroidogenesis_Homo sapiens_hsa049131.03298049
34Oocyte meiosis_Homo sapiens_hsa041141.02319038
35Dopaminergic synapse_Homo sapiens_hsa047281.01398668
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98871216
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96314782
38Axon guidance_Homo sapiens_hsa043600.91981608
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88151205
40Insulin secretion_Homo sapiens_hsa049110.86883259
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81176663
42Cholinergic synapse_Homo sapiens_hsa047250.77057792
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.76774836
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75576215
45Circadian entrainment_Homo sapiens_hsa047130.74007367
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73457565
47Olfactory transduction_Homo sapiens_hsa047400.72531099
48Ether lipid metabolism_Homo sapiens_hsa005650.71072947
49Steroid biosynthesis_Homo sapiens_hsa001000.70849351
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66794489
51Fatty acid biosynthesis_Homo sapiens_hsa000610.65952152
52RNA polymerase_Homo sapiens_hsa030200.65439738
53Salivary secretion_Homo sapiens_hsa049700.65418658
54Synaptic vesicle cycle_Homo sapiens_hsa047210.65206831
55Serotonergic synapse_Homo sapiens_hsa047260.63314142
56Hippo signaling pathway_Homo sapiens_hsa043900.61802591
57RNA transport_Homo sapiens_hsa030130.55657457
58Rheumatoid arthritis_Homo sapiens_hsa053230.54991151
59Bile secretion_Homo sapiens_hsa049760.54438999
60Caffeine metabolism_Homo sapiens_hsa002320.53867241
61Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50568819
62Dilated cardiomyopathy_Homo sapiens_hsa054140.49762548
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49240582
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48506782
65Gastric acid secretion_Homo sapiens_hsa049710.47145287
66Vibrio cholerae infection_Homo sapiens_hsa051100.46575226
67Butanoate metabolism_Homo sapiens_hsa006500.45211301
68Gap junction_Homo sapiens_hsa045400.45029637
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44956904
70Peroxisome_Homo sapiens_hsa041460.44453194
71Homologous recombination_Homo sapiens_hsa034400.43661933
72Melanogenesis_Homo sapiens_hsa049160.43462981
73mRNA surveillance pathway_Homo sapiens_hsa030150.43337002
74Tight junction_Homo sapiens_hsa045300.40964557
75Oxytocin signaling pathway_Homo sapiens_hsa049210.39478393
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38606773
77Cell cycle_Homo sapiens_hsa041100.36185919
78Hematopoietic cell lineage_Homo sapiens_hsa046400.33916333
79Metabolic pathways_Homo sapiens_hsa011000.33544353
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.31733066
81Inositol phosphate metabolism_Homo sapiens_hsa005620.31686423
82Basal cell carcinoma_Homo sapiens_hsa052170.31621895
83Hedgehog signaling pathway_Homo sapiens_hsa043400.30295489
84Melanoma_Homo sapiens_hsa052180.29904316
85Rap1 signaling pathway_Homo sapiens_hsa040150.28171395
86Chemical carcinogenesis_Homo sapiens_hsa052040.27840363
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.26669042
88Pancreatic secretion_Homo sapiens_hsa049720.26309973
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25845478
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25330580
91Asthma_Homo sapiens_hsa053100.24753613
92GnRH signaling pathway_Homo sapiens_hsa049120.24472816
93Salmonella infection_Homo sapiens_hsa051320.24341246
94Retinol metabolism_Homo sapiens_hsa008300.24166506
95TGF-beta signaling pathway_Homo sapiens_hsa043500.23825637
96Mineral absorption_Homo sapiens_hsa049780.23735506
97Renin secretion_Homo sapiens_hsa049240.22099017
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21706889
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.20921559
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20854380

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