ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.66304802
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.65151094
3	nucleobase catabolic process (GO:0046113)	3.91192806
4	detection of light stimulus involved in visual perception (GO:0050908)	3.80182062
5	detection of light stimulus involved in sensory perception (GO:0050962)	3.80182062
6	presynaptic membrane assembly (GO:0097105)	3.68181623
7	nonmotile primary cilium assembly (GO:0035058)	3.57105206
8	protein polyglutamylation (GO:0018095)	3.52715004
9	response to pheromone (GO:0019236)	3.47092327
10	regulation of glucokinase activity (GO:0033131)	3.42658039
11	regulation of hexokinase activity (GO:1903299)	3.42658039
12	postsynaptic membrane organization (GO:0001941)	3.40214326
13	presynaptic membrane organization (GO:0097090)	3.37108695
14	regulation of action potential (GO:0098900)	3.26740529
15	regulation of cilium movement (GO:0003352)	3.25812436
16	intraciliary transport (GO:0042073)	3.24462004
17	protein localization to cilium (GO:0061512)	3.22570438
18	cilium morphogenesis (GO:0060271)	3.17261360
19	axoneme assembly (GO:0035082)	3.15831228
20	neural tube formation (GO:0001841)	3.14019365
21	respiratory chain complex IV assembly (GO:0008535)	3.12286592
22	regulation of feeding behavior (GO:0060259)	3.11689136
23	protein complex biogenesis (GO:0070271)	3.09616419
24	neuron cell-cell adhesion (GO:0007158)	3.05244319
25	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04564669
26	somite development (GO:0061053)	3.03620877
27	water-soluble vitamin biosynthetic process (GO:0042364)	3.01038019
28	regulation of synapse structural plasticity (GO:0051823)	2.98227172
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.97332433
30	NADH dehydrogenase complex assembly (GO:0010257)	2.97332433
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.97332433
32	retinal ganglion cell axon guidance (GO:0031290)	2.95657873
33	neuronal action potential propagation (GO:0019227)	2.94325822
34	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.93208919
35	platelet dense granule organization (GO:0060155)	2.91232008
36	epithelial cilium movement (GO:0003351)	2.86333638
37	limb bud formation (GO:0060174)	2.86218569
38	L-fucose catabolic process (GO:0042355)	2.85567528
39	fucose catabolic process (GO:0019317)	2.85567528
40	L-fucose metabolic process (GO:0042354)	2.85567528
41	DNA double-strand break processing (GO:0000729)	2.76985099
42	positive regulation of mitochondrial fission (GO:0090141)	2.75566907
43	cytochrome complex assembly (GO:0017004)	2.75002505
44	cilium organization (GO:0044782)	2.73029483
45	positive regulation of action potential (GO:0045760)	2.72014825
46	mitochondrial respiratory chain complex assembly (GO:0033108)	2.71885111
47	GPI anchor metabolic process (GO:0006505)	2.71666625
48	regulation of skeletal muscle contraction (GO:0014819)	2.71484591
49	neuronal action potential (GO:0019228)	2.71442818
50	photoreceptor cell maintenance (GO:0045494)	2.70296428
51	photoreceptor cell development (GO:0042461)	2.69811487
52	DNA strand renaturation (GO:0000733)	2.69000173
53	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.68698643
54	cornea development in camera-type eye (GO:0061303)	2.68017648
55	protein-cofactor linkage (GO:0018065)	2.67988357
56	cilium assembly (GO:0042384)	2.67844318
57	ubiquinone biosynthetic process (GO:0006744)	2.67788990
58	synaptic transmission, cholinergic (GO:0007271)	2.67655540
59	ubiquinone metabolic process (GO:0006743)	2.67299399
60	reciprocal DNA recombination (GO:0035825)	2.66897286
61	reciprocal meiotic recombination (GO:0007131)	2.66897286
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65357400
63	gamma-aminobutyric acid transport (GO:0015812)	2.64983863
64	mannosylation (GO:0097502)	2.64489457
65	indolalkylamine metabolic process (GO:0006586)	2.60104518
66	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.60001705
67	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.59767475
68	cellular ketone body metabolic process (GO:0046950)	2.58471187
69	replication fork processing (GO:0031297)	2.57049731
70	retinal cone cell development (GO:0046549)	2.56528674
71	protein localization to synapse (GO:0035418)	2.53686502
72	cilium or flagellum-dependent cell motility (GO:0001539)	2.53179141
73	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.52251176
74	protein import into peroxisome matrix (GO:0016558)	2.51724565
75	neuromuscular synaptic transmission (GO:0007274)	2.51520207
76	cellular response to ATP (GO:0071318)	2.50485690
77	spinal cord motor neuron differentiation (GO:0021522)	2.50218372
78	ketone body metabolic process (GO:1902224)	2.49692927
79	piRNA metabolic process (GO:0034587)	2.47872354
80	C-terminal protein lipidation (GO:0006501)	2.46474997
81	eye photoreceptor cell development (GO:0042462)	2.46260271
82	meiotic chromosome segregation (GO:0045132)	2.43302002
83	negative regulation of axon guidance (GO:1902668)	2.43104820
84	negative regulation of telomere maintenance (GO:0032205)	2.43025664
85	C-terminal protein amino acid modification (GO:0018410)	2.41798531
86	startle response (GO:0001964)	2.40050700
87	axonal fasciculation (GO:0007413)	2.39801047
88	somite rostral/caudal axis specification (GO:0032525)	2.39281170
89	branched-chain amino acid catabolic process (GO:0009083)	2.36930501
90	synapse assembly (GO:0007416)	2.36905034
91	sympathetic nervous system development (GO:0048485)	2.35611249
92	tachykinin receptor signaling pathway (GO:0007217)	2.34647693
93	fatty acid elongation (GO:0030497)	2.34238377
94	transepithelial transport (GO:0070633)	2.32795003
95	glycosphingolipid biosynthetic process (GO:0006688)	2.30616894
96	regulation of telomere maintenance (GO:0032204)	2.30250205
97	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.29596350
98	transmission of nerve impulse (GO:0019226)	2.29502932
99	sequestering of actin monomers (GO:0042989)	2.27798823
100	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.26786795

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.69438523
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.31150702
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.22063769
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.20400838
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.08125969
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.74132005
7	TAF15_26573619_Chip-Seq_HEK293_Human	2.72811774
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67337776
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.64528719
10	VDR_22108803_ChIP-Seq_LS180_Human	2.61354088
11	FUS_26573619_Chip-Seq_HEK293_Human	2.52505659
12	EWS_26573619_Chip-Seq_HEK293_Human	2.41340869
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.38661633
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.33152777
15	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.28831473
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.06572717
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.04130955
18	P300_19829295_ChIP-Seq_ESCs_Human	1.93415983
19	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.90886339
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88703700
21	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.77144712
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.76587068
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72425649
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70549039
25	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.68807362
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.63872665
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62189146
28	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58772246
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.57535005
30	ER_23166858_ChIP-Seq_MCF-7_Human	1.56901331
31	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.54127010
32	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53724359
33	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50203686
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.49678252
35	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.49588004
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48980137
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47859449
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.47859449
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.46403821
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.44962873
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.44321106
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.44199117
43	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42666805
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41844802
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.41075143
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.38868288
47	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.37694663
48	AR_25329375_ChIP-Seq_VCAP_Human	1.36069800
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.35826370
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.33215247
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31333343
52	STAT3_23295773_ChIP-Seq_U87_Human	1.30504914
53	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.29535008
54	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.28588879
55	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.25657852
56	BCAT_22108803_ChIP-Seq_LS180_Human	1.25206418
57	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.24974085
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.24848835
59	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22523477
60	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.22085262
61	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21870475
62	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21870475
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18811837
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.18456146
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17997003
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17737461
67	TCF4_23295773_ChIP-Seq_U87_Human	1.16972084
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16868628
69	SOX2_19829295_ChIP-Seq_ESCs_Human	1.14990489
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.14990489
71	ELK1_19687146_ChIP-ChIP_HELA_Human	1.13745637
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.07240965
73	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06893965
74	NCOR_22424771_ChIP-Seq_293T_Human	1.04553006
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.04246046
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04047609
77	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03884241
78	RUNX2_22187159_ChIP-Seq_PCA_Human	1.03086986
79	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02204082
80	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02119552
81	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01772046
82	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.99774013
83	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98985048
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.97721453
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.97630261
86	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97218548
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96323892
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.95900562
89	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.95389788
90	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94571434
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.93748292
92	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.93492384
93	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.93045459
94	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.93033860
95	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92759346
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.92579088
97	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91669461
98	AR_21572438_ChIP-Seq_LNCaP_Human	0.91332159
99	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.89901930
100	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.89682442

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.34296448
2	MP0001986_abnormal_taste_sensitivity	2.91838164
3	MP0005423_abnormal_somatic_nervous	2.67950067
4	MP0002638_abnormal_pupillary_reflex	2.55015298
5	MP0003136_yellow_coat_color	2.48676585
6	MP0005171_absent_coat_pigmentation	2.45186226
7	MP0001968_abnormal_touch/_nociception	2.37832831
8	MP0006276_abnormal_autonomic_nervous	2.33178709
9	MP0003787_abnormal_imprinting	2.32419179
10	MP0002102_abnormal_ear_morphology	2.27026331
11	MP0005174_abnormal_tail_pigmentation	2.16175212
12	MP0002736_abnormal_nociception_after	2.09124432
13	MP0005551_abnormal_eye_electrophysiolog	2.08875820
14	MP0008877_abnormal_DNA_methylation	2.03129143
15	MP0001984_abnormal_olfaction	1.92553649
16	MP0006072_abnormal_retinal_apoptosis	1.88931617
17	MP0001529_abnormal_vocalization	1.86912875
18	MP0005253_abnormal_eye_physiology	1.86457182
19	MP0001188_hyperpigmentation	1.86393497
20	MP0002822_catalepsy	1.81578132
21	MP0000372_irregular_coat_pigmentation	1.80292377
22	MP0008789_abnormal_olfactory_epithelium	1.79637216
23	MP0004145_abnormal_muscle_electrophysio	1.78123189
24	MP0000569_abnormal_digit_pigmentation	1.76148484
25	MP0000778_abnormal_nervous_system	1.71299964
26	MP0003195_calcinosis	1.67660492
27	MP0002837_dystrophic_cardiac_calcinosis	1.64882133
28	MP0002735_abnormal_chemical_nociception	1.64109592
29	MP0004147_increased_porphyrin_level	1.61071535
30	MP0004133_heterotaxia	1.57863496
31	MP0002938_white_spotting	1.57151550
32	MP0005394_taste/olfaction_phenotype	1.55749478
33	MP0005499_abnormal_olfactory_system	1.55749478
34	MP0009745_abnormal_behavioral_response	1.55738325
35	MP0001486_abnormal_startle_reflex	1.52665756
36	MP0004142_abnormal_muscle_tone	1.49291321
37	MP0003121_genomic_imprinting	1.48954439
38	MP0003122_maternal_imprinting	1.41080316
39	MP0003011_delayed_dark_adaptation	1.40239761
40	MP0002909_abnormal_adrenal_gland	1.39903269
41	MP0009046_muscle_twitch	1.39878636
42	MP0000631_abnormal_neuroendocrine_gland	1.38984294
43	MP0002751_abnormal_autonomic_nervous	1.38793160
44	MP0002557_abnormal_social/conspecific_i	1.37986648
45	MP0002234_abnormal_pharynx_morphology	1.37294559
46	MP0006292_abnormal_olfactory_placode	1.35117019
47	MP0002928_abnormal_bile_duct	1.34883143
48	MP0002272_abnormal_nervous_system	1.33007646
49	MP0004043_abnormal_pH_regulation	1.32847094
50	MP0005645_abnormal_hypothalamus_physiol	1.32323835
51	MP0004924_abnormal_behavior	1.31660562
52	MP0005386_behavior/neurological_phenoty	1.31660562
53	MP0003635_abnormal_synaptic_transmissio	1.29533212
54	MP0002572_abnormal_emotion/affect_behav	1.26529989
55	MP0010386_abnormal_urinary_bladder	1.21185700
56	MP0002184_abnormal_innervation	1.19545793
57	MP0004885_abnormal_endolymph	1.17974211
58	MP0008875_abnormal_xenobiotic_pharmacok	1.16019901
59	MP0002064_seizures	1.15273322
60	MP0005084_abnormal_gallbladder_morpholo	1.14929216
61	MP0002063_abnormal_learning/memory/cond	1.14386979
62	MP0001970_abnormal_pain_threshold	1.14330293
63	MP0005646_abnormal_pituitary_gland	1.13783232
64	MP0008995_early_reproductive_senescence	1.13613479
65	MP0004270_analgesia	1.11777255
66	MP0000516_abnormal_urinary_system	1.11540411
67	MP0005367_renal/urinary_system_phenotyp	1.11540411
68	MP0002067_abnormal_sensory_capabilities	1.08333797
69	MP0002734_abnormal_mechanical_nocicepti	1.05885477
70	MP0002160_abnormal_reproductive_system	1.05377617
71	MP0002095_abnormal_skin_pigmentation	1.04647821
72	MP0000015_abnormal_ear_pigmentation	1.03874372
73	MP0000427_abnormal_hair_cycle	1.02326419
74	MP0003137_abnormal_impulse_conducting	1.01568465
75	MP0000955_abnormal_spinal_cord	1.01091508
76	MP0002752_abnormal_somatic_nervous	1.00974717
77	MP0008058_abnormal_DNA_repair	1.00316769
78	MP0004215_abnormal_myocardial_fiber	1.00225066
79	MP0003646_muscle_fatigue	0.98636363
80	MP0003718_maternal_effect	0.97994761
81	MP0001905_abnormal_dopamine_level	0.96803074
82	MP0001485_abnormal_pinna_reflex	0.96489273
83	MP0001502_abnormal_circadian_rhythm	0.95904318
84	MP0005075_abnormal_melanosome_morpholog	0.95854136
85	MP0000647_abnormal_sebaceous_gland	0.93609807
86	MP0003890_abnormal_embryonic-extraembry	0.92490869
87	MP0005195_abnormal_posterior_eye	0.90296170
88	MP0008872_abnormal_physiological_respon	0.89119458
89	MP0001324_abnormal_eye_pigmentation	0.88264538
90	MP0002882_abnormal_neuron_morphology	0.85516869
91	MP0003119_abnormal_digestive_system	0.85084006
92	MP0004811_abnormal_neuron_physiology	0.84182390
93	MP0005391_vision/eye_phenotype	0.83715981
94	MP0000026_abnormal_inner_ear	0.82935721
95	MP0002876_abnormal_thyroid_physiology	0.82916808
96	MP0000751_myopathy	0.81143066
97	MP0004085_abnormal_heartbeat	0.80003591
98	MP0005187_abnormal_penis_morphology	0.79391530
99	MP0003698_abnormal_male_reproductive	0.78589391
100	MP0004859_abnormal_synaptic_plasticity	0.77067491

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	3.90793454
2	Pancreatic cysts (HP:0001737)	3.59300296
3	True hermaphroditism (HP:0010459)	3.55430948
4	Pancreatic fibrosis (HP:0100732)	3.44224267
5	Abnormality of midbrain morphology (HP:0002418)	3.38392794
6	Molar tooth sign on MRI (HP:0002419)	3.38392794
7	Medial flaring of the eyebrow (HP:0010747)	3.33587818
8	Attenuation of retinal blood vessels (HP:0007843)	3.03886412
9	Nephrogenic diabetes insipidus (HP:0009806)	2.98921267
10	Gait imbalance (HP:0002141)	2.98423721
11	Type II lissencephaly (HP:0007260)	2.97519954
12	Nephronophthisis (HP:0000090)	2.96617403
13	Congenital primary aphakia (HP:0007707)	2.88129450
14	Rib fusion (HP:0000902)	2.74388520
15	Cerebellar dysplasia (HP:0007033)	2.70386284
16	Lissencephaly (HP:0001339)	2.57472593
17	Genital tract atresia (HP:0001827)	2.57216196
18	Methylmalonic acidemia (HP:0002912)	2.55258096
19	Abnormality of the renal medulla (HP:0100957)	2.53177101
20	Vaginal atresia (HP:0000148)	2.49897435
21	Hypothermia (HP:0002045)	2.49606181
22	Chronic hepatic failure (HP:0100626)	2.49027416
23	Chorioretinal atrophy (HP:0000533)	2.48640252
24	Hepatocellular necrosis (HP:0001404)	2.48114102
25	Bony spicule pigmentary retinopathy (HP:0007737)	2.45195322
26	Lipid accumulation in hepatocytes (HP:0006561)	2.44245334
27	Increased hepatocellular lipid droplets (HP:0006565)	2.42166002
28	Hemiparesis (HP:0001269)	2.39788307
29	Mitochondrial inheritance (HP:0001427)	2.37814432
30	Hyperventilation (HP:0002883)	2.34715831
31	Ketoacidosis (HP:0001993)	2.31187201
32	Decreased central vision (HP:0007663)	2.26308809
33	Absent speech (HP:0001344)	2.25775082
34	Retinal dysplasia (HP:0007973)	2.24949884
35	Hepatic necrosis (HP:0002605)	2.23631088
36	Increased CSF lactate (HP:0002490)	2.23198629
37	Cystic liver disease (HP:0006706)	2.20842200
38	Methylmalonic aciduria (HP:0012120)	2.20812972
39	Hyperglycinemia (HP:0002154)	2.19793619
40	Occipital encephalocele (HP:0002085)	2.19631930
41	Pendular nystagmus (HP:0012043)	2.19378075
42	Hyperinsulinemic hypoglycemia (HP:0000825)	2.18708627
43	Abnormal biliary tract physiology (HP:0012439)	2.17657936
44	Bile duct proliferation (HP:0001408)	2.17657936
45	Tubular atrophy (HP:0000092)	2.16481713
46	Polydipsia (HP:0001959)	2.15727288
47	Abnormal drinking behavior (HP:0030082)	2.15727288
48	Abnormality of the renal cortex (HP:0011035)	2.14987678
49	Large for gestational age (HP:0001520)	2.14549589
50	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.13114123
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.13069519
52	Polyphagia (HP:0002591)	2.11892937
53	Acute necrotizing encephalopathy (HP:0006965)	2.11875845
54	Broad-based gait (HP:0002136)	2.09754836
55	Abnormal rod and cone electroretinograms (HP:0008323)	2.09445253
56	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.08376052
57	Abnormal albumin level (HP:0012116)	2.06098470
58	Hypoalbuminemia (HP:0003073)	2.06098470
59	Abolished electroretinogram (ERG) (HP:0000550)	2.03976214
60	Gaze-evoked nystagmus (HP:0000640)	2.01369869
61	Tubulointerstitial nephritis (HP:0001970)	2.00371467
62	Fetal akinesia sequence (HP:0001989)	1.98558111
63	Focal motor seizures (HP:0011153)	1.97879584
64	Postaxial foot polydactyly (HP:0001830)	1.97296964
65	Postaxial hand polydactyly (HP:0001162)	1.96722703
66	Disproportionate short-trunk short stature (HP:0003521)	1.96028191
67	Acute encephalopathy (HP:0006846)	1.95271123
68	Congenital hepatic fibrosis (HP:0002612)	1.94985151
69	Short tibia (HP:0005736)	1.94732368
70	Intestinal atresia (HP:0011100)	1.94614060
71	Poor coordination (HP:0002370)	1.91912999
72	Ketosis (HP:0001946)	1.91912576
73	Abnormality of the labia minora (HP:0012880)	1.91768057
74	Patellar aplasia (HP:0006443)	1.91054709
75	Pachygyria (HP:0001302)	1.90902230
76	Renal Fanconi syndrome (HP:0001994)	1.89203981
77	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.88749931
78	Progressive macrocephaly (HP:0004481)	1.87980224
79	Severe muscular hypotonia (HP:0006829)	1.87705953
80	Hip dysplasia (HP:0001385)	1.84618323
81	Drooling (HP:0002307)	1.83017291
82	Abnormal mitochondria in muscle tissue (HP:0008316)	1.82786762
83	Anencephaly (HP:0002323)	1.78483822
84	Sclerocornea (HP:0000647)	1.78342103
85	Male pseudohermaphroditism (HP:0000037)	1.77962285
86	Aplasia/Hypoplasia of the patella (HP:0006498)	1.77221974
87	Tachypnea (HP:0002789)	1.76576363
88	Optic disc pallor (HP:0000543)	1.75558101
89	Retinitis pigmentosa (HP:0000510)	1.75513930
90	Abnormality of alanine metabolism (HP:0010916)	1.74712527
91	Hyperalaninemia (HP:0003348)	1.74712527
92	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74712527
93	Optic nerve hypoplasia (HP:0000609)	1.74065793
94	Febrile seizures (HP:0002373)	1.73017258
95	Specific learning disability (HP:0001328)	1.71010471
96	Inability to walk (HP:0002540)	1.70576021
97	Rectovaginal fistula (HP:0000143)	1.70571540
98	Rectal fistula (HP:0100590)	1.70571540
99	Increased intramyocellular lipid droplets (HP:0012240)	1.69837886
100	Aplasia/Hypoplasia of the lens (HP:0008063)	1.69826437

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.66320936
2	MAP4K2	3.58692141
3	WNK3	2.93414588
4	MARK1	2.67241865
5	MAP3K4	2.56304510
6	CASK	2.33475041
7	BMPR1B	2.29083947
8	MAPK13	2.24993746
9	NUAK1	2.15804571
10	ADRBK2	2.11879914
11	MAP2K7	2.09479589
12	MAPK15	2.08798849
13	TRIM28	2.05239296
14	ZAK	1.90095781
15	PINK1	1.83902393
16	BCKDK	1.73837478
17	WNK4	1.71874470
18	GRK1	1.69491658
19	DYRK2	1.67040308
20	PNCK	1.60752989
21	EPHA4	1.58647358
22	BCR	1.55011860
23	ERBB3	1.54226952
24	DAPK2	1.49965923
25	OBSCN	1.47890428
26	TNIK	1.38383110
27	ACVR1B	1.33010284
28	CSNK1G3	1.32021562
29	CSNK1G2	1.31714468
30	PAK3	1.31056346
31	CSNK1G1	1.27952668
32	TLK1	1.27668436
33	AKT3	1.25038705
34	MKNK2	1.22154075
35	CSNK1A1L	1.21320932
36	PLK2	1.11901529
37	DYRK3	1.11213125
38	OXSR1	1.06497293
39	PRKCE	1.06043105
40	PHKG1	1.04269512
41	PHKG2	1.04269512
42	MUSK	1.02457789
43	MAP2K4	1.02058881
44	NTRK2	1.01248592
45	INSRR	1.00522119
46	STK39	0.99903065
47	ADRBK1	0.97610060
48	PRKCG	0.91633214
49	CCNB1	0.90244547
50	VRK1	0.88041114
51	MINK1	0.79225935
52	BRD4	0.75344540
53	SIK2	0.73079378
54	STK16	0.72053078
55	PDK2	0.71185584
56	EPHA3	0.71169934
57	FER	0.70267101
58	STK11	0.68243922
59	MKNK1	0.67844030
60	RPS6KA4	0.65929650
61	TAOK3	0.64555751
62	PLK4	0.64054197
63	PRKAA1	0.63630404
64	SRPK1	0.63199265
65	SGK223	0.62655015
66	SGK494	0.62655015
67	SGK2	0.60571265
68	CAMK2A	0.57267896
69	PKN1	0.57233144
70	VRK2	0.55939125
71	RPS6KA5	0.55413216
72	TIE1	0.54453550
73	TAF1	0.53536322
74	CAMK1G	0.53510191
75	FGFR2	0.52267828
76	PRKACA	0.52241189
77	STK38L	0.51890583
78	CAMKK2	0.51700532
79	CSNK1D	0.51604863
80	BRSK2	0.51522349
81	PLK3	0.48919515
82	ATR	0.47811637
83	DYRK1B	0.46939307
84	EIF2AK3	0.45216219
85	CSNK1A1	0.44372649
86	DYRK1A	0.43488227
87	CDK5	0.43247206
88	FLT3	0.42441415
89	TGFBR1	0.42268978
90	CDK3	0.41465051
91	PLK1	0.39194923
92	PRKG1	0.38578078
93	MAP2K6	0.37958446
94	CAMK1	0.35819618
95	TEC	0.35010870
96	NTRK3	0.34873105
97	PIK3CA	0.33975030
98	PAK6	0.33893763
99	ATM	0.32896211
100	CAMK4	0.32580408

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.75905667
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.11230277
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.70800392
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.58935790
5	Nicotine addiction_Homo sapiens_hsa05033	2.56018659
6	Protein export_Homo sapiens_hsa03060	2.33822322
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.22534761
8	Phototransduction_Homo sapiens_hsa04744	2.20492325
9	Butanoate metabolism_Homo sapiens_hsa00650	2.14168995
10	Propanoate metabolism_Homo sapiens_hsa00640	2.12207760
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.10653758
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.01735620
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.99557658
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.84171176
15	Parkinsons disease_Homo sapiens_hsa05012	1.73665180
16	Fanconi anemia pathway_Homo sapiens_hsa03460	1.71850625
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70631286
18	Basal transcription factors_Homo sapiens_hsa03022	1.68592599
19	Taste transduction_Homo sapiens_hsa04742	1.57399387
20	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.52701894
21	RNA polymerase_Homo sapiens_hsa03020	1.49052116
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.48956184
23	Peroxisome_Homo sapiens_hsa04146	1.45989034
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42527924
25	Fatty acid elongation_Homo sapiens_hsa00062	1.42142552
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.40950710
27	Circadian rhythm_Homo sapiens_hsa04710	1.37254343
28	Non-homologous end-joining_Homo sapiens_hsa03450	1.35903905
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.30200601
30	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.28786039
31	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.26459218
32	Insulin secretion_Homo sapiens_hsa04911	1.25630909
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25562907
34	Tryptophan metabolism_Homo sapiens_hsa00380	1.23261059
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.21790494
36	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.21532149
37	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.21162729
38	Huntingtons disease_Homo sapiens_hsa05016	1.19190110
39	GABAergic synapse_Homo sapiens_hsa04727	1.18547547
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.10562463
41	Homologous recombination_Homo sapiens_hsa03440	1.10071511
42	Regulation of autophagy_Homo sapiens_hsa04140	1.09799211
43	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.08287077
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.07684619
45	Circadian entrainment_Homo sapiens_hsa04713	1.06738990
46	Steroid biosynthesis_Homo sapiens_hsa00100	1.05619056
47	Fatty acid metabolism_Homo sapiens_hsa01212	1.03773058
48	RNA degradation_Homo sapiens_hsa03018	1.03726252
49	Alzheimers disease_Homo sapiens_hsa05010	1.01685315
50	Morphine addiction_Homo sapiens_hsa05032	1.01011110
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98566518
52	Sulfur relay system_Homo sapiens_hsa04122	0.95868682
53	Glutamatergic synapse_Homo sapiens_hsa04724	0.93766293
54	Cocaine addiction_Homo sapiens_hsa05030	0.88223142
55	Olfactory transduction_Homo sapiens_hsa04740	0.88124729
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.81976646
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.79370129
58	Dopaminergic synapse_Homo sapiens_hsa04728	0.78405074
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75932948
60	ABC transporters_Homo sapiens_hsa02010	0.75742511
61	Fatty acid degradation_Homo sapiens_hsa00071	0.74378706
62	Alcoholism_Homo sapiens_hsa05034	0.72845436
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.70874605
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.70819213
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.69808701
66	Amphetamine addiction_Homo sapiens_hsa05031	0.68390111
67	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.66552170
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66179207
69	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.65657528
70	Sulfur metabolism_Homo sapiens_hsa00920	0.65208355
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.64848470
72	Serotonergic synapse_Homo sapiens_hsa04726	0.64778426
73	Metabolic pathways_Homo sapiens_hsa01100	0.64209365
74	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60029113
75	Caffeine metabolism_Homo sapiens_hsa00232	0.59891097
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.59572704
77	Purine metabolism_Homo sapiens_hsa00230	0.58755199
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.57620174
79	Axon guidance_Homo sapiens_hsa04360	0.56953025
80	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.56157994
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55335496
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53280545
83	Lysine degradation_Homo sapiens_hsa00310	0.52983513
84	Salivary secretion_Homo sapiens_hsa04970	0.51224435
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50114339
86	Retinol metabolism_Homo sapiens_hsa00830	0.49499272
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.49466665
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49025926
89	Long-term depression_Homo sapiens_hsa04730	0.44595147
90	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.42714409
91	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.40184283
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.38092443
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38054641
94	Oocyte meiosis_Homo sapiens_hsa04114	0.37756252
95	Base excision repair_Homo sapiens_hsa03410	0.37484349
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36735810
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36291466
98	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.34626301
99	Hippo signaling pathway_Homo sapiens_hsa04390	0.32860463
100	RNA transport_Homo sapiens_hsa03013	0.32522906

KRBA2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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