ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	6.18172730
2	piRNA metabolic process (GO:0034587)	5.96110272
3	aggressive behavior (GO:0002118)	5.46181811
4	male meiosis I (GO:0007141)	4.41398644
5	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.09499006
6	chromosome organization involved in meiosis (GO:0070192)	4.04116975
7	male meiosis (GO:0007140)	4.00924556
8	protein maturation by protein folding (GO:0022417)	3.86939210
9	meiosis I (GO:0007127)	3.78611014
10	regulation of glucokinase activity (GO:0033131)	3.75000789
11	regulation of hexokinase activity (GO:1903299)	3.75000789
12	DNA methylation involved in gamete generation (GO:0043046)	3.73815986
13	positive regulation of actin filament depolymerization (GO:0030836)	3.64118539
14	proteasome assembly (GO:0043248)	3.56492120
15	resolution of meiotic recombination intermediates (GO:0000712)	3.53809490
16	regulation of meiosis I (GO:0060631)	3.53453752
17	protein K6-linked ubiquitination (GO:0085020)	3.52863452
18	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.44105180
19	positive regulation of gastrulation (GO:2000543)	3.34734765
20	positive regulation of action potential (GO:0045760)	3.29576088
21	establishment of integrated proviral latency (GO:0075713)	3.27541446
22	nucleotide transmembrane transport (GO:1901679)	3.23045516
23	adult feeding behavior (GO:0008343)	3.20592679
24	mitochondrial DNA replication (GO:0006264)	3.20222051
25	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.12280652
26	establishment of viral latency (GO:0019043)	3.10135902
27	relaxation of smooth muscle (GO:0044557)	3.07232424
28	glucosamine-containing compound catabolic process (GO:1901072)	3.05047673
29	tachykinin receptor signaling pathway (GO:0007217)	3.04938424
30	platelet dense granule organization (GO:0060155)	3.03826831
31	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.03618769
32	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.00564908
33	positive regulation of digestive system process (GO:0060456)	2.99740854
34	response to gravity (GO:0009629)	2.97846419
35	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.97313832
36	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.94259111
37	regulation of cilium movement (GO:0003352)	2.93791820
38	histone H2A acetylation (GO:0043968)	2.93174398
39	protein complex biogenesis (GO:0070271)	2.91135088
40	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.89763235
41	righting reflex (GO:0060013)	2.88929702
42	regulation of retinoic acid receptor signaling pathway (GO:0048385)	2.88625786
43	meiotic nuclear division (GO:0007126)	2.88439795
44	type B pancreatic cell development (GO:0003323)	2.86310993
45	metaphase plate congression (GO:0051310)	2.85992727
46	DNA ligation (GO:0006266)	2.85896403
47	rRNA modification (GO:0000154)	2.85324595
48	meiotic cell cycle process (GO:1903046)	2.83165587
49	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.80437249
50	synaptonemal complex organization (GO:0070193)	2.79102890
51	pattern specification involved in kidney development (GO:0061004)	2.78992971
52	positive regulation of meiosis (GO:0045836)	2.77712463
53	regulation of mitochondrial translation (GO:0070129)	2.77325977
54	intraciliary transport (GO:0042073)	2.74482239
55	seminiferous tubule development (GO:0072520)	2.73653266
56	single strand break repair (GO:0000012)	2.72597616
57	keratinocyte development (GO:0003334)	2.72508210
58	meiotic cell cycle (GO:0051321)	2.70546702
59	positive regulation of vascular permeability (GO:0043117)	2.70146088
60	lactate metabolic process (GO:0006089)	2.68666548
61	positive regulation of meiotic cell cycle (GO:0051446)	2.67904962
62	reciprocal meiotic recombination (GO:0007131)	2.66141451
63	reciprocal DNA recombination (GO:0035825)	2.66141451
64	synaptonemal complex assembly (GO:0007130)	2.61955153
65	parental behavior (GO:0060746)	2.60818847
66	C-terminal protein lipidation (GO:0006501)	2.58932260
67	meiotic chromosome segregation (GO:0045132)	2.58227218
68	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.56393890
69	maternal behavior (GO:0042711)	2.53693677
70	retinal cone cell development (GO:0046549)	2.52770741
71	respiratory chain complex IV assembly (GO:0008535)	2.51786387
72	negative regulation of JAK-STAT cascade (GO:0046426)	2.51014066
73	cullin deneddylation (GO:0010388)	2.48930621
74	C-terminal protein amino acid modification (GO:0018410)	2.47719946
75	mitochondrial respiratory chain complex assembly (GO:0033108)	2.46960643
76	regulation of uterine smooth muscle contraction (GO:0070472)	2.46938469
77	negative regulation of nitric-oxide synthase activity (GO:0051001)	2.46670250
78	regulation of cellular amino acid metabolic process (GO:0006521)	2.46063196
79	drinking behavior (GO:0042756)	2.44854117
80	regulation of DNA endoreduplication (GO:0032875)	2.44820867
81	type B pancreatic cell proliferation (GO:0044342)	2.44724417
82	electron transport chain (GO:0022900)	2.41591939
83	positive regulation of male gonad development (GO:2000020)	2.41424098
84	ATP synthesis coupled proton transport (GO:0015986)	2.40817498
85	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.40817498
86	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.40371465
87	water-soluble vitamin biosynthetic process (GO:0042364)	2.40278451
88	respiratory electron transport chain (GO:0022904)	2.39688782
89	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.39650361
90	regulation of male gonad development (GO:2000018)	2.39215356
91	replication fork processing (GO:0031297)	2.38576004
92	positive regulation of histone H3-K4 methylation (GO:0051571)	2.36809213
93	xenobiotic catabolic process (GO:0042178)	2.36721164
94	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.36054524
95	kinetochore organization (GO:0051383)	2.35864784
96	sister chromatid cohesion (GO:0007062)	2.35324744
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.35080997
98	NADH dehydrogenase complex assembly (GO:0010257)	2.35080997
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.35080997
100	regulation of action potential (GO:0098900)	2.34534821

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.67360842
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.37793577
3	VDR_22108803_ChIP-Seq_LS180_Human	2.80858469
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.79304731
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.77711254
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.73218016
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.62722993
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.51676002
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51060187
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.49853296
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.40116662
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.26806606
13	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.16274568
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.09536174
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08805647
16	EZH2_22144423_ChIP-Seq_EOC_Human	2.06186948
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.04453967
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.95603766
19	FUS_26573619_Chip-Seq_HEK293_Human	1.95485985
20	EWS_26573619_Chip-Seq_HEK293_Human	1.93322269
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91313127
22	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.83051611
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.81199142
24	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.79463848
25	P300_19829295_ChIP-Seq_ESCs_Human	1.77767000
26	BCAT_22108803_ChIP-Seq_LS180_Human	1.75196609
27	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.74700767
28	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70207167
29	AR_25329375_ChIP-Seq_VCAP_Human	1.61014818
30	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.59233048
31	CJUN_26792858_Chip-Seq_BT549_Human	1.58534679
32	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.54723849
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.52840145
34	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51052042
35	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.49783607
36	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.49016449
37	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.42991434
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.42547243
39	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40137076
40	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.39988074
41	TAF15_26573619_Chip-Seq_HEK293_Human	1.39952964
42	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.38135348
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.37592565
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.33996376
45	VDR_23849224_ChIP-Seq_CD4+_Human	1.33584881
46	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.32159333
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.31305881
48	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.29760662
49	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.29278311
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29139832
51	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.28934203
52	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28913800
53	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.28674195
54	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.27222951
55	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.27181815
56	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27101858
57	BRD4_25478319_ChIP-Seq_HGPS_Human	1.26548510
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25183230
59	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24530252
60	ER_23166858_ChIP-Seq_MCF-7_Human	1.24380864
61	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.20261034
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.20245176
63	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.20202944
64	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.20202944
65	CBP_21632823_ChIP-Seq_H3396_Human	1.19946609
66	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.18093081
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17926985
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.16587788
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.16239007
70	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15889592
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.14996068
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14702633
73	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.14116372
74	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.13911511
75	STAT3_23295773_ChIP-Seq_U87_Human	1.11314221
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.11011498
77	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10586113
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.09917965
79	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.08958558
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.07886065
81	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.07664766
82	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.07231894
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06466591
84	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.05246502
85	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.05246502
86	TP53_22573176_ChIP-Seq_HFKS_Human	1.04913354
87	SOX2_19829295_ChIP-Seq_ESCs_Human	1.04402081
88	NANOG_19829295_ChIP-Seq_ESCs_Human	1.04402081
89	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.03945295
90	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03666365
91	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03500708
92	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02007196
93	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.01912425
94	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.00540996
95	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00246832
96	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.98248914
97	TCF4_23295773_ChIP-Seq_U87_Human	0.97773118
98	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97749025
99	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.96234254
100	AR_20517297_ChIP-Seq_VCAP_Human	0.96161656

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009780_abnormal_chondrocyte_physiolo	3.81322502
2	MP0008877_abnormal_DNA_methylation	3.21531608
3	MP0008058_abnormal_DNA_repair	2.86004205
4	MP0003950_abnormal_plasma_membrane	2.79124193
5	MP0003718_maternal_effect	2.77509960
6	MP0002837_dystrophic_cardiac_calcinosis	2.49062002
7	MP0000569_abnormal_digit_pigmentation	2.25024417
8	MP0001529_abnormal_vocalization	2.13529305
9	MP0002736_abnormal_nociception_after	2.04904052
10	MP0002277_abnormal_respiratory_mucosa	2.00492737
11	MP0002938_white_spotting	1.94390869
12	MP0002160_abnormal_reproductive_system	1.85854992
13	MP0006054_spinal_hemorrhage	1.77568522
14	MP0002282_abnormal_trachea_morphology	1.73559554
15	MP0005084_abnormal_gallbladder_morpholo	1.70037238
16	MP0000516_abnormal_urinary_system	1.69095386
17	MP0005367_renal/urinary_system_phenotyp	1.69095386
18	MP0009697_abnormal_copulation	1.67052668
19	MP0002210_abnormal_sex_determination	1.66352136
20	MP0001929_abnormal_gametogenesis	1.61750308
21	MP0000427_abnormal_hair_cycle	1.56362130
22	MP0003283_abnormal_digestive_organ	1.54361261
23	MP0003123_paternal_imprinting	1.53932638
24	MP0000749_muscle_degeneration	1.53671806
25	MP0010030_abnormal_orbit_morphology	1.53280387
26	MP0003786_premature_aging	1.52503562
27	MP0002234_abnormal_pharynx_morphology	1.51097292
28	MP0006072_abnormal_retinal_apoptosis	1.50707772
29	MP0004147_increased_porphyrin_level	1.49299465
30	MP0006292_abnormal_olfactory_placode	1.44272128
31	MP0005645_abnormal_hypothalamus_physiol	1.43620639
32	MP0001968_abnormal_touch/_nociception	1.42787308
33	MP0001299_abnormal_eye_distance/	1.39014891
34	MP0001542_abnormal_bone_strength	1.37449273
35	MP0004043_abnormal_pH_regulation	1.35107338
36	MP0005646_abnormal_pituitary_gland	1.33993322
37	MP0008875_abnormal_xenobiotic_pharmacok	1.32042951
38	MP0001986_abnormal_taste_sensitivity	1.30143667
39	MP0009046_muscle_twitch	1.30110077
40	MP0002638_abnormal_pupillary_reflex	1.28987326
41	MP0000653_abnormal_sex_gland	1.28533586
42	MP0005389_reproductive_system_phenotype	1.27694276
43	MP0010386_abnormal_urinary_bladder	1.27673595
44	MP0003698_abnormal_male_reproductive	1.26126879
45	MP0001145_abnormal_male_reproductive	1.25208343
46	MP0000013_abnormal_adipose_tissue	1.25013417
47	MP0000647_abnormal_sebaceous_gland	1.23993305
48	MP0002163_abnormal_gland_morphology	1.22955742
49	MP0002735_abnormal_chemical_nociception	1.22629773
50	MP0003315_abnormal_perineum_morphology	1.21183543
51	MP0002254_reproductive_system_inflammat	1.20215664
52	MP0005187_abnormal_penis_morphology	1.19796877
53	MP0001905_abnormal_dopamine_level	1.18177818
54	MP0005551_abnormal_eye_electrophysiolog	1.15686379
55	MP0008995_early_reproductive_senescence	1.13742950
56	MP0005395_other_phenotype	1.12320946
57	MP0005410_abnormal_fertilization	1.10785047
58	MP0006035_abnormal_mitochondrial_morpho	1.08697663
59	MP0000631_abnormal_neuroendocrine_gland	1.08192478
60	MP0006036_abnormal_mitochondrial_physio	1.07252973
61	MP0004215_abnormal_myocardial_fiber	1.06656214
62	MP0006276_abnormal_autonomic_nervous	1.05293810
63	MP0008775_abnormal_heart_ventricle	1.03086534
64	MP0008789_abnormal_olfactory_epithelium	1.02271319
65	MP0004142_abnormal_muscle_tone	1.01610260
66	MP0000383_abnormal_hair_follicle	0.99467860
67	MP0003121_genomic_imprinting	0.98082825
68	MP0001944_abnormal_pancreas_morphology	0.97625473
69	MP0002272_abnormal_nervous_system	0.96636940
70	MP0005379_endocrine/exocrine_gland_phen	0.96348741
71	MP0005330_cardiomyopathy	0.93051655
72	MP0005360_urolithiasis	0.91510528
73	MP0005253_abnormal_eye_physiology	0.89583210
74	MP0001984_abnormal_olfaction	0.89537302
75	MP0000566_synostosis	0.89446833
76	MP0004133_heterotaxia	0.89351919
77	MP0003936_abnormal_reproductive_system	0.88884451
78	MP0009745_abnormal_behavioral_response	0.88531100
79	MP0001485_abnormal_pinna_reflex	0.87326171
80	MP0005257_abnormal_intraocular_pressure	0.87254505
81	MP0002876_abnormal_thyroid_physiology	0.86999831
82	MP0010678_abnormal_skin_adnexa	0.86539354
83	MP0003186_abnormal_redox_activity	0.86368665
84	MP0004924_abnormal_behavior	0.85579233
85	MP0005386_behavior/neurological_phenoty	0.85579233
86	MP0000778_abnormal_nervous_system	0.85050596
87	MP0002928_abnormal_bile_duct	0.83907675
88	MP0003755_abnormal_palate_morphology	0.82808730
89	MP0005503_abnormal_tendon_morphology	0.82059338
90	MP0008872_abnormal_physiological_respon	0.81565467
91	MP0002693_abnormal_pancreas_physiology	0.81121188
92	MP0002177_abnormal_outer_ear	0.80873276
93	MP0005220_abnormal_exocrine_pancreas	0.80494249
94	MP0003195_calcinosis	0.79768719
95	MP0001119_abnormal_female_reproductive	0.79655119
96	MP0001502_abnormal_circadian_rhythm	0.79030680
97	MP0000534_abnormal_ureter_morphology	0.78826329
98	MP0010094_abnormal_chromosome_stability	0.76762960
99	MP0000762_abnormal_tongue_morphology	0.76519264
100	MP0008007_abnormal_cellular_replicative	0.75146714

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.96864915
2	Acute necrotizing encephalopathy (HP:0006965)	3.71649594
3	Abnormality of midbrain morphology (HP:0002418)	3.62339042
4	Molar tooth sign on MRI (HP:0002419)	3.62339042
5	Progressive macrocephaly (HP:0004481)	3.56734254
6	Congenital, generalized hypertrichosis (HP:0004540)	3.37152891
7	Nephronophthisis (HP:0000090)	3.17365298
8	Tubulointerstitial nephritis (HP:0001970)	3.16288885
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.11742710
10	Acute encephalopathy (HP:0006846)	3.04150372
11	Hypothermia (HP:0002045)	3.00472234
12	Mitochondrial inheritance (HP:0001427)	2.99169126
13	Volvulus (HP:0002580)	2.97591021
14	Pancreatic cysts (HP:0001737)	2.92394556
15	Medial flaring of the eyebrow (HP:0010747)	2.89298138
16	Oligodactyly (hands) (HP:0001180)	2.87519793
17	Increased CSF lactate (HP:0002490)	2.81179916
18	Pancreatic fibrosis (HP:0100732)	2.75634178
19	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.73981287
20	Sclerocornea (HP:0000647)	2.66091733
21	Abnormality of the renal medulla (HP:0100957)	2.62556777
22	Delayed gross motor development (HP:0002194)	2.55102101
23	Occipital encephalocele (HP:0002085)	2.53660516
24	Hepatic necrosis (HP:0002605)	2.51939080
25	Renal Fanconi syndrome (HP:0001994)	2.49867381
26	Median cleft lip (HP:0000161)	2.47192049
27	Oligodactyly (HP:0012165)	2.46082930
28	Retinal dysplasia (HP:0007973)	2.43865414
29	Bone cyst (HP:0012062)	2.41214317
30	Glucose intolerance (HP:0000833)	2.38663385
31	Hemiparesis (HP:0001269)	2.33856094
32	Large for gestational age (HP:0001520)	2.33465864
33	Hepatocellular necrosis (HP:0001404)	2.31381858
34	Short tibia (HP:0005736)	2.26299874
35	Male pseudohermaphroditism (HP:0000037)	2.24803096
36	Furrowed tongue (HP:0000221)	2.24725030
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23188450
38	Congenital primary aphakia (HP:0007707)	2.20847218
39	Gait imbalance (HP:0002141)	2.19691470
40	Delayed CNS myelination (HP:0002188)	2.16220776
41	Abnormal spermatogenesis (HP:0008669)	2.15464883
42	Sensory axonal neuropathy (HP:0003390)	2.12664424
43	Type II lissencephaly (HP:0007260)	2.11781598
44	Abnormality of the labia minora (HP:0012880)	2.10559108
45	Increased hepatocellular lipid droplets (HP:0006565)	2.09419661
46	Chronic hepatic failure (HP:0100626)	2.09404248
47	Fibular hypoplasia (HP:0003038)	2.08162448
48	Vascular calcification (HP:0004934)	2.04919860
49	Severe muscular hypotonia (HP:0006829)	2.04201257
50	Congenital hepatic fibrosis (HP:0002612)	2.03359493
51	Focal motor seizures (HP:0011153)	2.01580685
52	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.01379348
53	Postaxial foot polydactyly (HP:0001830)	2.00902878
54	Azoospermia (HP:0000027)	2.00789287
55	Shoulder girdle muscle weakness (HP:0003547)	2.00404276
56	Cerebral edema (HP:0002181)	1.99850605
57	Adrenal hypoplasia (HP:0000835)	1.99483537
58	Aplasia/hypoplasia of the uterus (HP:0008684)	1.97745518
59	Supernumerary spleens (HP:0009799)	1.96781387
60	Fibular aplasia (HP:0002990)	1.95283290
61	Cystic liver disease (HP:0006706)	1.93823807
62	Cardiovascular calcification (HP:0011915)	1.92975203
63	Postaxial hand polydactyly (HP:0001162)	1.92212231
64	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.89930529
65	Anencephaly (HP:0002323)	1.89652532
66	Hypoglycemic coma (HP:0001325)	1.85940440
67	Steatorrhea (HP:0002570)	1.83733678
68	Microglossia (HP:0000171)	1.83236716
69	Preaxial hand polydactyly (HP:0001177)	1.82760784
70	Congenital sensorineural hearing impairment (HP:0008527)	1.81724718
71	Conjunctival hamartoma (HP:0100780)	1.81531579
72	Congenital stationary night blindness (HP:0007642)	1.80851058
73	Palpitations (HP:0001962)	1.79407709
74	Axonal loss (HP:0003447)	1.78805820
75	Abnormality of renal resorption (HP:0011038)	1.78012327
76	Stillbirth (HP:0003826)	1.77290054
77	Opisthotonus (HP:0002179)	1.76915337
78	Respiratory failure (HP:0002878)	1.76765785
79	Lipid accumulation in hepatocytes (HP:0006561)	1.75961104
80	Reduced subcutaneous adipose tissue (HP:0003758)	1.75924258
81	Nephrogenic diabetes insipidus (HP:0009806)	1.74928815
82	Amniotic constriction ring (HP:0009775)	1.73257745
83	Abnormality of placental membranes (HP:0011409)	1.73257745
84	Entropion (HP:0000621)	1.72734222
85	Meckel diverticulum (HP:0002245)	1.70351615
86	Abnormal drinking behavior (HP:0030082)	1.69632729
87	Polydipsia (HP:0001959)	1.69632729
88	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68216715
89	Increased serum lactate (HP:0002151)	1.67824537
90	Testicular atrophy (HP:0000029)	1.66290389
91	Constricted visual fields (HP:0001133)	1.65151454
92	Oculomotor apraxia (HP:0000657)	1.63273948
93	Muscular hypotonia of the trunk (HP:0008936)	1.62953036
94	Hypoplastic labia majora (HP:0000059)	1.62289350
95	Gaze-evoked nystagmus (HP:0000640)	1.61724927
96	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.61237099
97	Abnormality of alanine metabolism (HP:0010916)	1.61237099
98	Hyperalaninemia (HP:0003348)	1.61237099
99	Abnormality of the labia (HP:0000058)	1.61225353
100	Abnormality of the anterior horn cell (HP:0006802)	1.60798392

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	5.85556698
2	FRK	3.39269121
3	WEE1	3.26263767
4	LIMK1	3.03406985
5	VRK2	2.91109508
6	PINK1	2.60002767
7	WNK3	2.59850177
8	BRSK2	2.45669733
9	MST4	2.21162395
10	TSSK6	1.98754717
11	VRK1	1.90956108
12	MAP4K2	1.77992225
13	TESK1	1.76759368
14	MAPK15	1.74405688
15	MAPK13	1.67166340
16	MAP3K12	1.62200881
17	MST1R	1.53162301
18	NUAK1	1.40036384
19	PLK3	1.38791225
20	EPHA2	1.38619424
21	BUB1	1.35879799
22	MAPKAPK3	1.35142386
23	MET	1.25710317
24	TLK1	1.18147793
25	DAPK2	1.18029019
26	PTK2B	1.17130630
27	ERBB3	1.15585756
28	ABL2	1.14207859
29	PLK2	1.11760055
30	ARAF	1.10989723
31	CCNB1	1.09730265
32	BRSK1	1.07526843
33	PHKG2	1.03970041
34	PHKG1	1.03970041
35	PLK4	1.03722858
36	EIF2AK3	1.02407154
37	CDK3	1.00187520
38	STK38L	0.99891351
39	MYLK	0.99683516
40	TNIK	0.98494060
41	MUSK	0.96741086
42	ROCK1	0.93077717
43	BMPR1B	0.92198560
44	AKT3	0.91009593
45	EPHB2	0.89608345
46	LMTK2	0.88772630
47	GRK1	0.88159230
48	PRKCI	0.87738097
49	TAOK3	0.86562842
50	STK3	0.86000548
51	NEK9	0.82415589
52	PRKCE	0.82384355
53	NEK1	0.78093015
54	PAK3	0.77523086
55	PLK1	0.77004376
56	MAP2K7	0.76031889
57	CAMK2D	0.72826838
58	CSNK1G1	0.71130783
59	MINK1	0.66485495
60	BRAF	0.65010318
61	ADRBK1	0.63507565
62	BCKDK	0.62380113
63	SRPK1	0.62058681
64	PRKCG	0.62043759
65	GSK3A	0.59906682
66	NME2	0.58236799
67	CDK8	0.57352023
68	MAP3K2	0.56867315
69	EPHA4	0.55382190
70	ERBB4	0.54903607
71	TRPM7	0.54813248
72	NEK2	0.53656972
73	TRIM28	0.52889259
74	MARK1	0.52416274
75	DAPK1	0.50181137
76	PTK2	0.49944602
77	STK16	0.49364194
78	CAMK2G	0.48785036
79	PIM2	0.46239107
80	NTRK3	0.46032594
81	MKNK2	0.44706317
82	YES1	0.44291781
83	RPS6KA5	0.44121250
84	CSNK1G3	0.43046422
85	TAF1	0.40123230
86	PDK2	0.40113953
87	EIF2AK1	0.39508806
88	AURKA	0.39405043
89	TAOK2	0.39235142
90	FGFR2	0.38497170
91	CSNK1G2	0.37957495
92	GRK5	0.37743622
93	ILK	0.36951280
94	RAF1	0.36947456
95	CAMK2A	0.36267688
96	MAP2K1	0.36114499
97	STK10	0.36066718
98	STK38	0.35527417
99	INSRR	0.34801985
100	TESK2	0.33932440

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.49549083
2	Folate biosynthesis_Homo sapiens_hsa00790	3.22618778
3	Protein export_Homo sapiens_hsa03060	3.18902349
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.16381626
5	RNA polymerase_Homo sapiens_hsa03020	2.67407240
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.58867386
7	Parkinsons disease_Homo sapiens_hsa05012	2.51267151
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.48735932
9	Huntingtons disease_Homo sapiens_hsa05016	2.15906207
10	Basal transcription factors_Homo sapiens_hsa03022	1.81873872
11	Mismatch repair_Homo sapiens_hsa03430	1.80913535
12	Alzheimers disease_Homo sapiens_hsa05010	1.79000936
13	Sulfur relay system_Homo sapiens_hsa04122	1.78743003
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74924279
15	Propanoate metabolism_Homo sapiens_hsa00640	1.74811407
16	Butanoate metabolism_Homo sapiens_hsa00650	1.72198250
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.68052991
18	Circadian rhythm_Homo sapiens_hsa04710	1.67730465
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.67252415
20	Homologous recombination_Homo sapiens_hsa03440	1.66643644
21	Ribosome_Homo sapiens_hsa03010	1.63042533
22	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.57008906
23	Fatty acid elongation_Homo sapiens_hsa00062	1.53310057
24	Regulation of autophagy_Homo sapiens_hsa04140	1.52057228
25	Cardiac muscle contraction_Homo sapiens_hsa04260	1.47205950
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.46018388
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.41944404
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.39345392
29	Base excision repair_Homo sapiens_hsa03410	1.37885743
30	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37511215
31	Salivary secretion_Homo sapiens_hsa04970	1.32178632
32	Purine metabolism_Homo sapiens_hsa00230	1.27903187
33	DNA replication_Homo sapiens_hsa03030	1.20560671
34	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.08246447
35	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.07770727
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.07231681
37	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.06003333
38	Phototransduction_Homo sapiens_hsa04744	1.05666931
39	Glutathione metabolism_Homo sapiens_hsa00480	1.04160957
40	RNA degradation_Homo sapiens_hsa03018	0.98808321
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.98561173
42	Sulfur metabolism_Homo sapiens_hsa00920	0.96974012
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96576238
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.95251251
45	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95152217
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93426407
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.92881983
48	Insulin secretion_Homo sapiens_hsa04911	0.90449788
49	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87805272
50	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.86185540
51	Non-homologous end-joining_Homo sapiens_hsa03450	0.82864843
52	Mineral absorption_Homo sapiens_hsa04978	0.81183548
53	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.78608818
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76272009
55	RNA transport_Homo sapiens_hsa03013	0.74218794
56	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.73505625
57	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73234387
58	Oocyte meiosis_Homo sapiens_hsa04114	0.72481537
59	Metabolic pathways_Homo sapiens_hsa01100	0.72412100
60	Cell cycle_Homo sapiens_hsa04110	0.66414822
61	One carbon pool by folate_Homo sapiens_hsa00670	0.66390682
62	Peroxisome_Homo sapiens_hsa04146	0.65081810
63	Pyruvate metabolism_Homo sapiens_hsa00620	0.64478416
64	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64416745
65	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64268832
66	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63788554
67	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.62017326
68	Caffeine metabolism_Homo sapiens_hsa00232	0.60807578
69	p53 signaling pathway_Homo sapiens_hsa04115	0.60465537
70	Basal cell carcinoma_Homo sapiens_hsa05217	0.59802450
71	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59601427
72	Tyrosine metabolism_Homo sapiens_hsa00350	0.57974520
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57267009
74	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.55269979
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54655225
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51545857
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50977389
78	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.50482506
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50432243
80	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.50368165
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.50344329
82	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.49556193
83	Amphetamine addiction_Homo sapiens_hsa05031	0.47200849
84	Circadian entrainment_Homo sapiens_hsa04713	0.45459835
85	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45259882
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.44096843
87	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44076662
88	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.43533150
89	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41048227
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.39385178
91	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.37193830
92	ABC transporters_Homo sapiens_hsa02010	0.36571408
93	Long-term depression_Homo sapiens_hsa04730	0.36168529
94	Calcium signaling pathway_Homo sapiens_hsa04020	0.33384573
95	Taste transduction_Homo sapiens_hsa04742	0.32955519
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.31251697
97	Pancreatic secretion_Homo sapiens_hsa04972	0.30643895
98	Spliceosome_Homo sapiens_hsa03040	0.29618576
99	Histidine metabolism_Homo sapiens_hsa00340	0.28973562
100	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.28661125

KRBOX1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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