KRCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H4-K12 acetylation (GO:0043983)4.95187019
2adenosine metabolic process (GO:0046085)3.85319000
3fatty acid elongation (GO:0030497)3.77510524
4macroautophagy (GO:0016236)3.68894255
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.65689474
6L-phenylalanine catabolic process (GO:0006559)3.65689474
7microglial cell activation (GO:0001774)3.63505746
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.57622633
9L-phenylalanine metabolic process (GO:0006558)3.57622633
10macrophage activation involved in immune response (GO:0002281)3.53031838
11autophagic vacuole fusion (GO:0000046)3.48246659
12phagocytosis, engulfment (GO:0006911)3.47198541
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.46176998
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.46176998
15fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44604641
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40046288
17valine metabolic process (GO:0006573)3.38243961
18regulation of sequestering of triglyceride (GO:0010889)3.35069895
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30526147
20aromatic amino acid family catabolic process (GO:0009074)3.24131816
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.13284479
22negative regulation of cell killing (GO:0031342)3.13284479
23antigen processing and presentation of endogenous antigen (GO:0019883)3.09239262
24cysteine metabolic process (GO:0006534)3.08725856
25intra-S DNA damage checkpoint (GO:0031573)3.04987115
26fatty acid beta-oxidation (GO:0006635)3.02468681
27regulation of plasminogen activation (GO:0010755)3.01165558
28complement activation, alternative pathway (GO:0006957)2.97407992
29amino-acid betaine metabolic process (GO:0006577)2.95929661
30regulation of triglyceride catabolic process (GO:0010896)2.95531203
31inner ear receptor cell development (GO:0060119)2.94113743
32sulfur amino acid catabolic process (GO:0000098)2.91882591
33skeletal muscle tissue regeneration (GO:0043403)2.91707651
34fatty acid oxidation (GO:0019395)2.91408767
35signal peptide processing (GO:0006465)2.90934646
36organelle membrane fusion (GO:0090174)2.90843852
37carnitine metabolic process (GO:0009437)2.90702189
38glyoxylate metabolic process (GO:0046487)2.87882713
39lipid oxidation (GO:0034440)2.85483567
40tryptophan metabolic process (GO:0006568)2.85359732
41indole-containing compound catabolic process (GO:0042436)2.84361284
42indolalkylamine catabolic process (GO:0046218)2.84361284
43tryptophan catabolic process (GO:0006569)2.84361284
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.82949028
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.82949028
46retinol metabolic process (GO:0042572)2.82843249
47interleukin-6-mediated signaling pathway (GO:0070102)2.82245939
48aldehyde catabolic process (GO:0046185)2.80573096
49cellular glucuronidation (GO:0052695)2.79876379
50alpha-linolenic acid metabolic process (GO:0036109)2.79685954
51neutrophil activation involved in immune response (GO:0002283)2.78490462
52negative regulation of gene silencing (GO:0060969)2.76073821
53glucuronate metabolic process (GO:0019585)2.75866161
54uronic acid metabolic process (GO:0006063)2.75866161
55protein carboxylation (GO:0018214)2.74441853
56peptidyl-glutamic acid carboxylation (GO:0017187)2.74441853
57bile acid biosynthetic process (GO:0006699)2.73644262
58response to nitrosative stress (GO:0051409)2.73159506
59chemokine-mediated signaling pathway (GO:0070098)2.72891380
60cellular extravasation (GO:0045123)2.72819577
61pyrimidine-containing compound transmembrane transport (GO:0072531)2.71407089
62regulation of cholesterol storage (GO:0010885)2.68584719
63white fat cell differentiation (GO:0050872)2.68001528
64negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.67011470
65plasma lipoprotein particle clearance (GO:0034381)2.66300235
66membrane invagination (GO:0010324)2.66269949
67positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65806124
68regulation of germinal center formation (GO:0002634)2.63962478
69response to interferon-beta (GO:0035456)2.63423263
70regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.63151126
71homocysteine metabolic process (GO:0050667)2.62617716
72positive regulation of interferon-alpha production (GO:0032727)2.62277662
73phospholipid efflux (GO:0033700)2.62227557
74response to lipoprotein particle (GO:0055094)2.59124030
75fatty acid catabolic process (GO:0009062)2.58799941
76low-density lipoprotein particle clearance (GO:0034383)2.58501644
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.58061820
78acylglycerol homeostasis (GO:0055090)2.57442635
79triglyceride homeostasis (GO:0070328)2.57442635
80cellular response to interferon-beta (GO:0035458)2.57226770
81urea metabolic process (GO:0019627)2.56229127
82urea cycle (GO:0000050)2.56229127
83negative regulation of interleukin-12 production (GO:0032695)2.56087493
84negative regulation of lipid storage (GO:0010888)2.54959836
85regulation of type B pancreatic cell apoptotic process (GO:2000674)2.54203008
86positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53656790
87regulation of extracellular matrix disassembly (GO:0010715)2.53355609
88regulation of integrin-mediated signaling pathway (GO:2001044)2.52474312
89regulation of endothelial cell differentiation (GO:0045601)2.45868514
90regulation of interferon-alpha production (GO:0032647)2.44871024
91ethanol oxidation (GO:0006069)2.43979334
92kynurenine metabolic process (GO:0070189)2.42976880
93sequestering of extracellular ligand from receptor (GO:0035581)2.42204584
94plasma lipoprotein particle remodeling (GO:0034369)2.41190333
95protein-lipid complex remodeling (GO:0034368)2.41190333
96macromolecular complex remodeling (GO:0034367)2.41190333
97heme transport (GO:0015886)2.40606153
98adaptation of signaling pathway (GO:0023058)2.40393838
99bile acid metabolic process (GO:0008206)2.38663160
100positive regulation of fatty acid oxidation (GO:0046321)2.37839251
101high-density lipoprotein particle remodeling (GO:0034375)2.37469578
102cell migration involved in heart development (GO:0060973)2.37376142
103platelet dense granule organization (GO:0060155)2.36682227
104production of molecular mediator involved in inflammatory response (GO:0002532)2.36069692
105cellular response to zinc ion (GO:0071294)2.35651053
106positive regulation of protein autophosphorylation (GO:0031954)2.35648903
107positive regulation of lipid catabolic process (GO:0050996)2.35301667
108nitrogen cycle metabolic process (GO:0071941)2.34650548
109tyrosine metabolic process (GO:0006570)2.34327780
110regulation of protein activation cascade (GO:2000257)2.34265827
111hydrogen peroxide biosynthetic process (GO:0050665)2.33742101
112monocarboxylic acid catabolic process (GO:0072329)2.33555648
113response to type I interferon (GO:0034340)2.33466924
114cellular defense response (GO:0006968)2.33352270
115aromatic amino acid family metabolic process (GO:0009072)2.32790178
116positive regulation of endothelial cell differentiation (GO:0045603)2.31681428
117xenobiotic catabolic process (GO:0042178)2.31658064
118neutrophil activation (GO:0042119)2.31603625
119type I interferon signaling pathway (GO:0060337)2.31015970
120cellular response to type I interferon (GO:0071357)2.31015970
121triglyceride catabolic process (GO:0019433)2.30622665
122regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.30594521
123drug transmembrane transport (GO:0006855)2.30484625
124positive regulation of fatty acid beta-oxidation (GO:0032000)2.29944520
125negative regulation of fibrinolysis (GO:0051918)2.29492337
126response to xenobiotic stimulus (GO:0009410)2.28721161
127flavonoid metabolic process (GO:0009812)2.28579456
128regulation of cholesterol metabolic process (GO:0090181)2.28375446
129detection of calcium ion (GO:0005513)2.27890870
130negative regulation of fatty acid biosynthetic process (GO:0045717)2.27492057
131positive regulation of gamma-delta T cell activation (GO:0046645)2.27461310
132regulation of mononuclear cell migration (GO:0071675)2.26934505
133regulation of vitamin metabolic process (GO:0030656)2.26616371
134branched-chain amino acid metabolic process (GO:0009081)2.26458735
135myoblast migration (GO:0051451)2.26411533
136regulation of cholesterol esterification (GO:0010872)2.25032179
137lysine metabolic process (GO:0006553)2.24826688
138lysine catabolic process (GO:0006554)2.24826688
139positive regulation of lipid storage (GO:0010884)2.24621110
140hepatocyte apoptotic process (GO:0097284)2.24217504
141protein targeting to lysosome (GO:0006622)2.23463928
142establishment of protein localization to vacuole (GO:0072666)2.23463928
143protein targeting to vacuole (GO:0006623)2.23463928
144negative regulation of execution phase of apoptosis (GO:1900118)2.23415041
145regulation of complement activation (GO:0030449)2.23360982
146positive regulation of triglyceride lipase activity (GO:0061365)2.22953507
147positive regulation of lipoprotein lipase activity (GO:0051006)2.22953507
148myeloid cell activation involved in immune response (GO:0002275)2.22486028
149fibrinolysis (GO:0042730)2.22435667
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.22122890
151regulation of interleukin-8 secretion (GO:2000482)2.20421511
152reactive oxygen species biosynthetic process (GO:1903409)2.19953906
153regulation of regulatory T cell differentiation (GO:0045589)2.19937614
154interferon-gamma production (GO:0032609)2.18986607
155natural killer cell mediated cytotoxicity (GO:0042267)2.18934078
156natural killer cell mediated immunity (GO:0002228)2.18934078
157amyloid precursor protein catabolic process (GO:0042987)2.18854519
158mitochondrial calcium ion transport (GO:0006851)2.18817081
159branched-chain amino acid catabolic process (GO:0009083)2.18319098
160primary alcohol metabolic process (GO:0034308)2.17440805
161cellular response to interleukin-15 (GO:0071350)2.16894496
162lipid storage (GO:0019915)2.16651574
163short-chain fatty acid metabolic process (GO:0046459)2.16607251
164bile acid and bile salt transport (GO:0015721)2.16572704
165reverse cholesterol transport (GO:0043691)2.16249612
166macrophage chemotaxis (GO:0048246)2.15827602
167regulation of fibroblast apoptotic process (GO:2000269)2.15759366
168regulation of B cell receptor signaling pathway (GO:0050855)2.15622889
169pathway-restricted SMAD protein phosphorylation (GO:0060389)2.15474913
170defense response to Gram-negative bacterium (GO:0050829)2.15051615
171desmosome organization (GO:0002934)2.13665338
172dendritic cell migration (GO:0036336)2.12485680
173macrophage activation (GO:0042116)2.11860794
174negative regulation of anoikis (GO:2000811)2.10297156
175negative regulation of DNA biosynthetic process (GO:2000279)2.07072813
176cellular response to gamma radiation (GO:0071480)2.06866205
177negative regulation of acute inflammatory response (GO:0002674)2.04179719
178histamine secretion (GO:0001821)2.03030151
179regulation of vitamin D biosynthetic process (GO:0060556)2.02179595
180radial glial cell differentiation (GO:0060019)2.00701733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.14547870
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.51095940
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15184694
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.77947638
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.51342709
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.48664378
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.43976588
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.14378236
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.05331278
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.86600321
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.84104168
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.76566460
13GATA1_22025678_ChIP-Seq_K562_Human2.75516659
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.67256836
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.63814281
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.63754908
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60134112
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.47104712
19BP1_19119308_ChIP-ChIP_Hs578T_Human2.26277319
20* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23382468
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22506572
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.21756017
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19852284
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.14592400
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10549524
26POU3F2_20337985_ChIP-ChIP_501MEL_Human2.10280187
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10234233
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.99810881
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.98225039
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97535452
31RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.95367672
32CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79229400
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.76182016
34CLOCK_20551151_ChIP-Seq_293T_Human1.75309312
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73710336
36VDR_22108803_ChIP-Seq_LS180_Human1.72655171
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66792696
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65879377
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.65593887
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.65113313
41CDX2_22108803_ChIP-Seq_LS180_Human1.63487472
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63269169
43BCAT_22108803_ChIP-Seq_LS180_Human1.59920251
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.59451943
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.56565814
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53713599
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50837305
48CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.49914608
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49219626
50SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48851186
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45673716
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44834260
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44003640
54ER_23166858_ChIP-Seq_MCF-7_Human1.43108073
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.42588650
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41331607
57BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41269281
58P300_19829295_ChIP-Seq_ESCs_Human1.41156674
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39557902
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39281639
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37220723
62FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36690620
63GATA4_25053715_ChIP-Seq_YYC3_Human1.36272906
64MYB_26560356_Chip-Seq_TH2_Human1.35787931
65CJUN_26792858_Chip-Seq_BT549_Human1.35659736
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35453328
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34349952
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33557441
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33060091
70* SPI1_23547873_ChIP-Seq_NB4_Human1.33012170
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32366821
72FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32007790
73NFE2_27457419_Chip-Seq_LIVER_Mouse1.31371451
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30649651
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.29169006
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28998440
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.27698026
78GBX2_23144817_ChIP-Seq_PC3_Human1.27190973
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25386882
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24891879
81SOX2_20726797_ChIP-Seq_SW620_Human1.24280562
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24229648
83* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22161406
84PU_27001747_Chip-Seq_BMDM_Mouse1.21517700
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.21426279
86FUS_26573619_Chip-Seq_HEK293_Human1.18438155
87OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18175400
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18061066
89MYB_26560356_Chip-Seq_TH1_Human1.17857065
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.17468524
91RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16541815
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14594761
93NANOG_19829295_ChIP-Seq_ESCs_Human1.13811170
94SOX2_19829295_ChIP-Seq_ESCs_Human1.13811170
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.11094422
96TP53_18474530_ChIP-ChIP_U2OS_Human1.10195649
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10049880
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.09765933
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.09736826
100* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09304391
101RUNX_20019798_ChIP-Seq_JUKART_Human1.09024356
102SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08566898
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08262595
104P53_22387025_ChIP-Seq_ESCs_Mouse1.07422553
105SCL_19346495_ChIP-Seq_HPC-7_Human1.07189508
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.06970323
107* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06590567
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06090587
109EP300_21415370_ChIP-Seq_HL-1_Mouse1.05872688
110* SMAD4_21799915_ChIP-Seq_A2780_Human1.05593618
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03556004
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02972124
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02972124
114* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02718829
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02532500
116GATA3_26560356_Chip-Seq_TH2_Human1.02194429
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.01063364
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00950784
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00579892
120TCF4_22108803_ChIP-Seq_LS180_Human1.00400536
121BRD4_25478319_ChIP-Seq_HGPS_Human1.00234157
122MAF_26560356_Chip-Seq_TH1_Human0.99574942
123* GATA3_27048872_Chip-Seq_THYMUS_Human0.99436447
124TP63_23658742_ChIP-Seq_EP156T_Human0.99086453
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98685198
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98535642
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97473009
128FOXA1_27270436_Chip-Seq_PROSTATE_Human0.97427602
129FOXA1_25329375_ChIP-Seq_VCAP_Human0.97427602
130CMYC_18555785_Chip-Seq_ESCs_Mouse0.97393638
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96980367
132PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96937782
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96806703
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96523837
135ARNT_22903824_ChIP-Seq_MCF-7_Human0.96450648
136AR_20517297_ChIP-Seq_VCAP_Human0.95822511
137RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95517933
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94998735
139EGR1_19374776_ChIP-ChIP_THP-1_Human0.94829493
140CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94555328
141AR_25329375_ChIP-Seq_VCAP_Human0.94206504
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.94121031
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93950774
144RUNX1_22412390_ChIP-Seq_EML_Mouse0.93806067
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93442812
146IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93399968
147CBP_20019798_ChIP-Seq_JUKART_Human0.93399968
148STAT3_23295773_ChIP-Seq_U87_Human0.93287876
149ESR1_21235772_ChIP-Seq_MCF-7_Human0.92578075
150GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92359010
151SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92346924
152HTT_18923047_ChIP-ChIP_STHdh_Human0.91566510
153NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91336826
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91336826
155CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91285220
156HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90471390
157ELK1_19687146_ChIP-ChIP_HELA_Human0.89532756
158PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88979365
159TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88443787
160PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87128050
161GATA6_25053715_ChIP-Seq_YYC3_Human0.84485234
162VDR_24787735_ChIP-Seq_THP-1_Human0.83945810
163LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83501320
164CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82861177
165P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82259305
166ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80865091
167GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79661335
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.79234901
169VDR_24763502_ChIP-Seq_THP-1_Human0.78827758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.55756195
2MP0005360_urolithiasis3.24731164
3MP0003183_abnormal_peptide_metabolism2.96895504
4MP0005365_abnormal_bile_salt2.84104753
5MP0003195_calcinosis2.70251056
6MP0005085_abnormal_gallbladder_physiolo2.66146407
7MP0004883_abnormal_blood_vessel2.46129087
8MP0003724_increased_susceptibility_to2.29910446
9MP0001835_abnormal_antigen_presentation2.27117929
10MP0008875_abnormal_xenobiotic_pharmacok2.12770231
11MP0003252_abnormal_bile_duct2.10126875
12MP0003806_abnormal_nucleotide_metabolis2.07438332
13MP0003436_decreased_susceptibility_to2.02687474
14MP0004043_abnormal_pH_regulation2.02413036
15MP0003191_abnormal_cellular_cholesterol1.97984437
16MP0005164_abnormal_response_to1.96425860
17MP0000013_abnormal_adipose_tissue1.95514140
18MP0003186_abnormal_redox_activity1.86963130
19MP0009785_altered_susceptibility_to1.84400388
20MP0002138_abnormal_hepatobiliary_system1.82391489
21MP0002837_dystrophic_cardiac_calcinosis1.78236625
22MP0002166_altered_tumor_susceptibility1.71999671
23MP0003303_peritoneal_inflammation1.70974649
24MP0010329_abnormal_lipoprotein_level1.64582880
25MP0004885_abnormal_endolymph1.63023533
26MP0002148_abnormal_hypersensitivity_rea1.61345074
27MP0009780_abnormal_chondrocyte_physiolo1.59936614
28MP0005367_renal/urinary_system_phenotyp1.58833882
29MP0000516_abnormal_urinary_system1.58833882
30MP0005670_abnormal_white_adipose1.58012566
31MP0000685_abnormal_immune_system1.57248942
32MP0009840_abnormal_foam_cell1.50816101
33MP0003045_fibrosis1.50279703
34MP0003279_aneurysm1.49657231
35MP0002419_abnormal_innate_immunity1.48284575
36MP0001666_abnormal_nutrient_absorption1.48017308
37MP0005025_abnormal_response_to1.47957236
38MP0000609_abnormal_liver_physiology1.45846496
39MP0005332_abnormal_amino_acid1.44136056
40MP0002132_abnormal_respiratory_system1.43638350
41MP0006054_spinal_hemorrhage1.42913689
42MP0005000_abnormal_immune_tolerance1.40341971
43MP0005166_decreased_susceptibility_to1.40208509
44MP0003828_pulmonary_edema1.39300226
45MP0005397_hematopoietic_system_phenotyp1.38919463
46MP0001545_abnormal_hematopoietic_system1.38919463
47MP0009643_abnormal_urine_homeostasis1.37874965
48MP0001790_abnormal_immune_system1.35542657
49MP0005387_immune_system_phenotype1.35542657
50MP0005058_abnormal_lysosome_morphology1.34723686
51MP0008469_abnormal_protein_level1.34108342
52MP0006082_CNS_inflammation1.33575230
53MP0005451_abnormal_body_composition1.33150021
54MP0005379_endocrine/exocrine_gland_phen1.33008570
55MP0002006_tumorigenesis1.32201257
56MP0008004_abnormal_stomach_pH1.30854017
57MP0001542_abnormal_bone_strength1.30474141
58MP0005319_abnormal_enzyme/_coenzyme1.27836359
59MP0009764_decreased_sensitivity_to1.27657604
60MP0010234_abnormal_vibrissa_follicle1.26575604
61MP0004782_abnormal_surfactant_physiolog1.25785586
62MP0004185_abnormal_adipocyte_glucose1.25687043
63MP0005671_abnormal_response_to1.24014746
64MP0005666_abnormal_adipose_tissue1.23530062
65MP0001845_abnormal_inflammatory_respons1.23472601
66MP0001533_abnormal_skeleton_physiology1.22591237
67MP0002118_abnormal_lipid_homeostasis1.22177020
68MP0002452_abnormal_antigen_presenting1.21765549
69MP0001800_abnormal_humoral_immune1.21250915
70MP0005595_abnormal_vascular_smooth1.20208816
71MP0004947_skin_inflammation1.20095966
72MP0009697_abnormal_copulation1.19250717
73MP0002877_abnormal_melanocyte_morpholog1.18565641
74MP0010155_abnormal_intestine_physiology1.18523478
75MP0008438_abnormal_cutaneous_collagen1.16393183
76MP0002723_abnormal_immune_serum1.15408976
77MP0005464_abnormal_platelet_physiology1.15175674
78MP0002168_other_aberrant_phenotype1.15098791
79MP0003300_gastrointestinal_ulcer1.14642890
80MP0004084_abnormal_cardiac_muscle1.13727803
81MP0005275_abnormal_skin_tensile1.13479327
82MP0001853_heart_inflammation1.11915440
83MP0008260_abnormal_autophagy1.11150442
84MP0009763_increased_sensitivity_to1.09388766
85MP0000538_abnormal_urinary_bladder1.08732020
86MP0002295_abnormal_pulmonary_circulatio1.08135304
87MP0002405_respiratory_system_inflammati1.07232225
88MP0001958_emphysema1.06775219
89MP0002060_abnormal_skin_morphology1.05154819
90MP0004019_abnormal_vitamin_homeostasis1.05077824
91MP0002277_abnormal_respiratory_mucosa1.04120137
92MP0000343_altered_response_to1.03307487
93MP0002971_abnormal_brown_adipose1.02013059
94MP0005083_abnormal_biliary_tract1.01901932
95MP0001819_abnormal_immune_cell1.01430238
96MP0002420_abnormal_adaptive_immunity1.01116166
97MP0001663_abnormal_digestive_system1.00318732
98MP0005408_hypopigmentation1.00139166
99MP0002254_reproductive_system_inflammat0.99274427
100MP0003705_abnormal_hypodermis_morpholog0.98208400
101MP0003763_abnormal_thymus_physiology0.97274614
102MP0004130_abnormal_muscle_cell0.96629407
103MP0000230_abnormal_systemic_arterial0.96040688
104MP0000598_abnormal_liver_morphology0.95031974
105MP0005584_abnormal_enzyme/coenzyme_acti0.94705288
106MP0002896_abnormal_bone_mineralization0.93904918
107MP0002009_preneoplasia0.92789867
108MP0010386_abnormal_urinary_bladder0.92672823
109MP0005023_abnormal_wound_healing0.90554879
110MP0003566_abnormal_cell_adhesion0.90481481
111MP0005646_abnormal_pituitary_gland0.88895847
112MP0003453_abnormal_keratinocyte_physiol0.88853829
113MP0002796_impaired_skin_barrier0.88546398
114MP0002136_abnormal_kidney_physiology0.88012551
115MP0001764_abnormal_homeostasis0.87361283
116MP0002653_abnormal_ependyma_morphology0.86890294
117MP0004264_abnormal_extraembryonic_tissu0.86263776
118MP0000465_gastrointestinal_hemorrhage0.84775057
119MP0009333_abnormal_splenocyte_physiolog0.83847957
120MP0000249_abnormal_blood_vessel0.83126152
121MP0001485_abnormal_pinna_reflex0.82940833
122MP0004484_altered_response_of0.82883625
123MP0005503_abnormal_tendon_morphology0.82841459
124MP0001915_intracranial_hemorrhage0.82744307
125MP0008872_abnormal_physiological_respon0.82446965
126MP0002876_abnormal_thyroid_physiology0.82016118
127MP0003690_abnormal_glial_cell0.81877909
128MP0005375_adipose_tissue_phenotype0.81103203
129MP0009384_cardiac_valve_regurgitation0.80723562
130MP0002102_abnormal_ear_morphology0.80433898
131MP0000858_altered_metastatic_potential0.79717501
132MP0001216_abnormal_epidermal_layer0.79707595
133MP0005636_abnormal_mineral_homeostasis0.79659508
134MP0003868_abnormal_feces_composition0.76631600
135MP0000716_abnormal_immune_system0.76168024
136MP0001756_abnormal_urination0.75984755
137MP0002998_abnormal_bone_remodeling0.75309261
138MP0003656_abnormal_erythrocyte_physiolo0.74074867
139MP0002396_abnormal_hematopoietic_system0.72701522
140MP0005334_abnormal_fat_pad0.71913721
141MP0001873_stomach_inflammation0.70856750
142MP0002933_joint_inflammation0.70823795
143MP0001243_abnormal_dermal_layer0.70350113
144MP0005084_abnormal_gallbladder_morpholo0.69883781

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.28849697
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.17490960
3Intrahepatic cholestasis (HP:0001406)3.75433128
4Hematochezia (HP:0002573)3.71550306
5Xanthomatosis (HP:0000991)3.62461896
6Generalized aminoaciduria (HP:0002909)3.55870261
7Eczematoid dermatitis (HP:0000976)3.47008823
8Absent rod-and cone-mediated responses on ERG (HP:0007688)3.43814930
9Recurrent gram-negative bacterial infections (HP:0005420)3.35592196
10Myocardial infarction (HP:0001658)3.32224478
11Renal cortical cysts (HP:0000803)3.23727435
12Abnormality of fatty-acid metabolism (HP:0004359)3.19752020
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19585605
14Nausea (HP:0002018)3.14480755
15Constricted visual fields (HP:0001133)3.08185844
16Deep venous thrombosis (HP:0002625)3.07089819
17Complement deficiency (HP:0004431)3.06875245
18Autoimmune thrombocytopenia (HP:0001973)3.05150355
19Abnormal rod and cone electroretinograms (HP:0008323)3.03373176
20Prolonged partial thromboplastin time (HP:0003645)3.01022792
21Hyperlipoproteinemia (HP:0010980)3.00425502
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00201319
23Abnormality of alanine metabolism (HP:0010916)3.00201319
24Hyperalaninemia (HP:0003348)3.00201319
25Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93664451
26Recurrent bacterial skin infections (HP:0005406)2.92734709
27Abnormality of the common coagulation pathway (HP:0010990)2.87602909
28Recurrent abscess formation (HP:0002722)2.85311863
29Thyroiditis (HP:0100646)2.84637242
30Chronic sinusitis (HP:0011109)2.84354343
31Disinhibition (HP:0000734)2.82632526
32Chronic otitis media (HP:0000389)2.82009256
33Vacuolated lymphocytes (HP:0001922)2.77318387
34Epidermoid cyst (HP:0200040)2.75947772
35Hyperammonemia (HP:0001987)2.71485932
36Hypobetalipoproteinemia (HP:0003563)2.68464532
37Abnormal respiratory epithelium morphology (HP:0012253)2.67530048
38Abnormal respiratory motile cilium morphology (HP:0005938)2.67530048
39Joint hemorrhage (HP:0005261)2.66563203
40Ketosis (HP:0001946)2.65271518
41Fat malabsorption (HP:0002630)2.64604866
42Dicarboxylic aciduria (HP:0003215)2.63609565
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.63609565
44Systemic lupus erythematosus (HP:0002725)2.61035279
45Abnormality of proline metabolism (HP:0010907)2.60967160
46Hydroxyprolinuria (HP:0003080)2.60967160
47Oligomenorrhea (HP:0000876)2.59250291
48Abnormality of the intrinsic pathway (HP:0010989)2.58836390
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.58580711
50Recurrent sinusitis (HP:0011108)2.57743851
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.57718113
52Increased corneal curvature (HP:0100692)2.53853550
53Keratoconus (HP:0000563)2.53853550
54Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49530309
55T lymphocytopenia (HP:0005403)2.49434716
56Congenital sensorineural hearing impairment (HP:0008527)2.47197795
57Glucose intolerance (HP:0000833)2.47041469
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45484829
59Abnormality of glycolipid metabolism (HP:0010969)2.43990787
60Abnormality of liposaccharide metabolism (HP:0010968)2.43990787
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.43990787
62Eosinophilia (HP:0001880)2.43787811
63Abnormality of complement system (HP:0005339)2.42348028
64Granulocytopenia (HP:0001913)2.41685644
65Leukocytosis (HP:0001974)2.40260359
66Microcytic anemia (HP:0001935)2.37712477
67Hyperglycinuria (HP:0003108)2.37593426
68Abnormality of eosinophils (HP:0001879)2.35887795
69Hypolipoproteinemia (HP:0010981)2.35781814
70Hypercholesterolemia (HP:0003124)2.35458922
71Severe visual impairment (HP:0001141)2.35329531
72Vasculitis (HP:0002633)2.33652428
73Hypoalphalipoproteinemia (HP:0003233)2.30080418
74Beaking of vertebral bodies (HP:0004568)2.26144497
75Pancreatitis (HP:0001733)2.25274852
76Absent/shortened dynein arms (HP:0200106)2.23314429
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.23314429
78Abnormality of methionine metabolism (HP:0010901)2.23191402
79Proximal tubulopathy (HP:0000114)2.23112874
80Hypochromic microcytic anemia (HP:0004840)2.22950674
81Steatorrhea (HP:0002570)2.22854914
82Hypoproteinemia (HP:0003075)2.22441975
83Abnormality of vitamin metabolism (HP:0100508)2.22432998
84Peritonitis (HP:0002586)2.21952722
85Abnormality of serine family amino acid metabolism (HP:0010894)2.20217672
86Abnormality of glycine metabolism (HP:0010895)2.20217672
87Hypoglycemic seizures (HP:0002173)2.20150202
88Ketoacidosis (HP:0001993)2.18988074
89Acanthocytosis (HP:0001927)2.18847521
90Abnormality of macrophages (HP:0004311)2.18177650
91Abnormality of sulfur amino acid metabolism (HP:0004339)2.18138729
92Patchy hypopigmentation of hair (HP:0011365)2.17964033
93Gingival bleeding (HP:0000225)2.16575522
94Myositis (HP:0100614)2.15650088
95Abnormality of purine metabolism (HP:0004352)2.15500132
96Pulmonary embolism (HP:0002204)2.14765231
97Hypoplasia of the thymus (HP:0000778)2.12511845
98Abnormality of vitamin B metabolism (HP:0004340)2.12169432
99Abnormality of the renal cortex (HP:0011035)2.10730037
100Abnormal hemoglobin (HP:0011902)2.08294646
101Decreased central vision (HP:0007663)2.08148602
102Glomerulonephritis (HP:0000099)2.06886470
103Petechiae (HP:0000967)2.04550294
104Elevated erythrocyte sedimentation rate (HP:0003565)2.03524499
105Recurrent skin infections (HP:0001581)2.00793419
106Stomatitis (HP:0010280)2.00048515
107Esophageal varix (HP:0002040)1.99972384
108Conjunctival telangiectasia (HP:0000524)1.99192163
109Hyperbilirubinemia (HP:0002904)1.99029245
110True hermaphroditism (HP:0010459)1.98966917
111Hepatocellular carcinoma (HP:0001402)1.97810041
112Attenuation of retinal blood vessels (HP:0007843)1.97302015
113Aortic aneurysm (HP:0004942)1.96316026
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.96078209
115Right ventricular cardiomyopathy (HP:0011663)1.95848985
116Recurrent bronchitis (HP:0002837)1.95505131
117Autoimmune hemolytic anemia (HP:0001890)1.95397707
118Periodontitis (HP:0000704)1.94974450
119Pancreatic fibrosis (HP:0100732)1.93509513
120Anorexia (HP:0002039)1.92576856
121Glycosuria (HP:0003076)1.92337765
122Abnormality of urine glucose concentration (HP:0011016)1.92337765
123Hypertriglyceridemia (HP:0002155)1.92090308
124Chronic diarrhea (HP:0002028)1.92011908
125Vascular calcification (HP:0004934)1.92010083
126Abnormal ciliary motility (HP:0012262)1.91655495
127Pustule (HP:0200039)1.91498741
128Abnormality of B cell number (HP:0010975)1.91406822
129Panhypogammaglobulinemia (HP:0003139)1.91216140
130Pigmentary retinal degeneration (HP:0001146)1.90624331
131Bronchiectasis (HP:0002110)1.90495072
132Decreased circulating renin level (HP:0003351)1.90109181
133Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89446951
134Abolished electroretinogram (ERG) (HP:0000550)1.88957289
135Abnormal cartilage morphology (HP:0002763)1.88809836
136Acute hepatic failure (HP:0006554)1.88715898
137Alveolar cell carcinoma (HP:0006519)1.88237314
138Conjugated hyperbilirubinemia (HP:0002908)1.88013800
139Severe combined immunodeficiency (HP:0004430)1.87113711
140Retrobulbar optic neuritis (HP:0100654)1.86476072
141Optic neuritis (HP:0100653)1.86476072
142B lymphocytopenia (HP:0010976)1.86096765
143Osteolytic defects of the phalanges of the hand (HP:0009771)1.85694263
144Osteolytic defects of the hand bones (HP:0009699)1.85694263
145Metabolic acidosis (HP:0001942)1.84946955
146Increased CSF protein (HP:0002922)1.84809276
147Abnormality of nucleobase metabolism (HP:0010932)1.84666367
148Urticaria (HP:0001025)1.84575455
149Disproportionate short-trunk short stature (HP:0003521)1.84455128
150Hyperglycemia (HP:0003074)1.83678268
151Rhinitis (HP:0012384)1.83032148
152Orchitis (HP:0100796)1.82008748
153Abnormal respiratory motile cilium physiology (HP:0012261)1.81923963
154Spontaneous hematomas (HP:0007420)1.81241191
155Pulmonary infiltrates (HP:0002113)1.81179729
156Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80780916
157Cardiovascular calcification (HP:0011915)1.79683751
158Toxemia of pregnancy (HP:0100603)1.78618082
159Asplenia (HP:0001746)1.78540369
160Tetraparesis (HP:0002273)1.78382156
161Abnormality of T cell number (HP:0011839)1.78351111
162Nasal polyposis (HP:0100582)1.78116275
163Thrombocytosis (HP:0001894)1.78099533
164Hepatosplenomegaly (HP:0001433)1.77888907
165Facial diplegia (HP:0001349)1.76784821
166Hyperglycinemia (HP:0002154)1.76151384
167Curly hair (HP:0002212)1.76050069
168Neoplasm of the tracheobronchial system (HP:0100552)1.74325303
169Insulin-resistant diabetes mellitus (HP:0000831)1.74297620
170Pendular nystagmus (HP:0012043)1.74223348
171Nephritis (HP:0000123)1.73578795
172Thrombophlebitis (HP:0004418)1.72485927
173Increased cerebral lipofuscin (HP:0011813)1.72095675
174Syringomyelia (HP:0003396)1.71894036
175Spinal cord lesions (HP:0100561)1.71894036
176Hemorrhage of the eye (HP:0011885)1.71752570
177Interstitial pulmonary disease (HP:0006530)1.71659890
178Axonal loss (HP:0003447)1.70404296
179Abnormality of the nasal mucosa (HP:0000433)1.69749231
180Elevated hepatic transaminases (HP:0002910)1.68729972
181Epistaxis (HP:0000421)1.66972915
182Nonimmune hydrops fetalis (HP:0001790)1.66641094
183Recurrent fungal infections (HP:0002841)1.65630499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B3.56763992
2AKT33.52987127
3MAP3K142.83453560
4TAF12.68677380
5NEK92.49691467
6ERN12.48387795
7TYK22.46114105
8BCKDK2.41151675
9TNIK2.26641361
10TAOK32.15239424
11NME22.12869143
12MST42.10187450
13TBK12.07067818
14IRAK31.97983853
15PBK1.94764915
16IRAK41.91588737
17TEC1.86323651
18JAK31.83154953
19MAP4K11.70092805
20FGFR41.69797744
21FLT31.69445901
22IKBKE1.66906348
23RPS6KA41.56223602
24PIK3CG1.52622291
25PIM21.51103942
26TGFBR21.48422222
27JAK11.47928651
28TRPM71.45411631
29MAPK151.42809900
30NUAK11.40509155
31STK101.39485795
32LATS11.38063799
33EPHB11.36073751
34ILK1.36044463
35MAP3K31.36011527
36FRK1.34905030
37SGK21.34054979
38TXK1.33950588
39MST1R1.33230422
40ZAP701.32752279
41NLK1.29890129
42MAP3K121.29797871
43KIT1.28534994
44STK31.24808440
45IKBKB1.24080832
46STK241.21612962
47CSK1.19968787
48FGR1.15821398
49BTK1.15618392
50SIK11.14658869
51ITK1.12617997
52LMTK21.08597635
53CHUK1.08248240
54GRK71.08041482
55TRIB31.05419309
56LRRK21.04140427
57PRKCE1.01978870
58MAP4K21.00381384
59INSRR0.99888529
60EPHA30.99285474
61WNK30.97374171
62GRK60.95175482
63MUSK0.94268717
64CDK60.94244930
65MAP2K30.92974079
66BLK0.91939053
67PINK10.91405401
68GRK10.89899888
69PIM10.88605243
70TESK10.88209572
71EIF2AK30.87102076
72KDR0.85589474
73PRKD20.83046527
74ADRBK10.82875996
75JAK20.82237810
76MAP3K130.82031034
77TAOK10.81181663
78IRAK10.80917817
79STK40.79775621
80PAK30.79509142
81ABL20.79359237
82PTK60.78898931
83PKN20.78348013
84HIPK20.77552552
85TGFBR10.75071980
86SGK2230.73982287
87SGK4940.73982287
88CAMK1D0.72701369
89SIK30.72347572
90DYRK1B0.72035167
91CSF1R0.71559889
92PTK20.70598539
93SGK30.69451655
94WNK40.69406796
95BMPR1B0.68587330
96MOS0.67232717
97PRKAA20.67050739
98ERBB30.66799284
99FGFR30.66357189
100PDK20.65526394
101ROCK10.64880532
102STK38L0.64386762
103MATK0.64330480
104CDK90.63371832
105LCK0.62820634
106MAPKAPK30.62627764
107BRSK20.62475466
108MYLK0.61814173
109MAPKAPK20.61023491
110EIF2AK20.59998996
111TNK20.59496928
112RIPK10.59491085
113EPHB20.59262288
114MAPK110.59257638
115ADRBK20.59167081
116PRKG20.58228516
117PTK2B0.58079398
118RIPK40.57674097
119MARK30.57027293
120FES0.56667498
121TIE10.56005908
122ABL10.55902609
123TRIM280.55264436
124TESK20.54643261
125MET0.54504849
126HCK0.53358479
127LYN0.51858949
128FGFR20.51708055
129YES10.50796766
130PLK20.49652789
131DDR20.49531367
132PIK3CA0.49392033
133IGF1R0.48704791
134ZAK0.46571264
135RPS6KA50.46100738
136MAP2K60.45588451
137CAMK2D0.44806923
138MAPK130.44650410
139PDK40.44043599
140PDK30.44043599
141PRKCQ0.43879764
142OBSCN0.43580602
143BMPR20.42774265
144PRKD10.42262823
145PRKG10.42219221
146SYK0.41499532
147FER0.40493487
148STK110.39488288

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.70419171
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53874997
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46362799
4Fatty acid degradation_Homo sapiens_hsa000712.40843426
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.23118338
6SNARE interactions in vesicular transport_Homo sapiens_hsa041302.11859567
7Caffeine metabolism_Homo sapiens_hsa002322.06365388
8Propanoate metabolism_Homo sapiens_hsa006402.06151154
9Staphylococcus aureus infection_Homo sapiens_hsa051502.04564445
10Peroxisome_Homo sapiens_hsa041462.01902092
11Regulation of autophagy_Homo sapiens_hsa041401.96490673
12PPAR signaling pathway_Homo sapiens_hsa033201.95287711
13Sulfur metabolism_Homo sapiens_hsa009201.94949350
14Tryptophan metabolism_Homo sapiens_hsa003801.91855266
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.89951913
16Complement and coagulation cascades_Homo sapiens_hsa046101.89076956
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.86687136
18Type I diabetes mellitus_Homo sapiens_hsa049401.76335192
19Protein export_Homo sapiens_hsa030601.75160348
20Folate biosynthesis_Homo sapiens_hsa007901.70815956
21Nitrogen metabolism_Homo sapiens_hsa009101.69995113
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67608545
23Histidine metabolism_Homo sapiens_hsa003401.65261882
24Chemical carcinogenesis_Homo sapiens_hsa052041.64443671
25Asthma_Homo sapiens_hsa053101.61319937
26Selenocompound metabolism_Homo sapiens_hsa004501.52881360
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.52241799
28Fatty acid metabolism_Homo sapiens_hsa012121.46621478
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.46146362
30beta-Alanine metabolism_Homo sapiens_hsa004101.40518838
31Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39119612
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37983878
33Retinol metabolism_Homo sapiens_hsa008301.35248407
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.27757251
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25817274
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25201368
37Fatty acid elongation_Homo sapiens_hsa000621.24475578
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.23513317
39Arginine biosynthesis_Homo sapiens_hsa002201.23325275
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22522879
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21674515
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21216295
43Starch and sucrose metabolism_Homo sapiens_hsa005001.18683619
44Legionellosis_Homo sapiens_hsa051341.17150905
45Rheumatoid arthritis_Homo sapiens_hsa053231.16060317
46ABC transporters_Homo sapiens_hsa020101.13371497
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10669189
48Glutathione metabolism_Homo sapiens_hsa004801.09473513
49Leishmaniasis_Homo sapiens_hsa051401.07042168
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.04423782
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98771599
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97622847
53Fat digestion and absorption_Homo sapiens_hsa049750.97463243
54Chemokine signaling pathway_Homo sapiens_hsa040620.97307806
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.95620614
56Graft-versus-host disease_Homo sapiens_hsa053320.95380201
57Antigen processing and presentation_Homo sapiens_hsa046120.94963852
58Mineral absorption_Homo sapiens_hsa049780.93310215
59Butanoate metabolism_Homo sapiens_hsa006500.93045913
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92090947
61Tyrosine metabolism_Homo sapiens_hsa003500.91511850
62Phenylalanine metabolism_Homo sapiens_hsa003600.89566436
63Pyruvate metabolism_Homo sapiens_hsa006200.89139415
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88767507
65Other glycan degradation_Homo sapiens_hsa005110.88686022
66RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87891701
67Measles_Homo sapiens_hsa051620.87185707
68Collecting duct acid secretion_Homo sapiens_hsa049660.86315530
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84764323
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84327538
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82430764
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81853586
73Carbon metabolism_Homo sapiens_hsa012000.81055658
74Phagosome_Homo sapiens_hsa041450.80834368
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.80759336
76Lysosome_Homo sapiens_hsa041420.79644231
77Phototransduction_Homo sapiens_hsa047440.78982720
78Pentose phosphate pathway_Homo sapiens_hsa000300.75782135
79African trypanosomiasis_Homo sapiens_hsa051430.72964316
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72464793
81Malaria_Homo sapiens_hsa051440.72329129
82Renin secretion_Homo sapiens_hsa049240.69125208
83Sulfur relay system_Homo sapiens_hsa041220.67963621
84Protein digestion and absorption_Homo sapiens_hsa049740.67832767
85Vitamin digestion and absorption_Homo sapiens_hsa049770.66867980
86Glycerolipid metabolism_Homo sapiens_hsa005610.66857391
87Herpes simplex infection_Homo sapiens_hsa051680.66734469
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.65933479
89Pertussis_Homo sapiens_hsa051330.65772720
90Allograft rejection_Homo sapiens_hsa053300.65583186
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.65359293
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.65298788
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64858014
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64219810
95Amoebiasis_Homo sapiens_hsa051460.63712475
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63358169
97Platelet activation_Homo sapiens_hsa046110.62718714
98Osteoclast differentiation_Homo sapiens_hsa043800.62201076
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62174958
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62059045
101Steroid biosynthesis_Homo sapiens_hsa001000.61281731
102Arachidonic acid metabolism_Homo sapiens_hsa005900.60150662
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59532199
104Linoleic acid metabolism_Homo sapiens_hsa005910.58842558
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58639751
106Influenza A_Homo sapiens_hsa051640.58300911
107Renin-angiotensin system_Homo sapiens_hsa046140.56702174
108Serotonergic synapse_Homo sapiens_hsa047260.55787312
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55694600
110TNF signaling pathway_Homo sapiens_hsa046680.55366356
111Hematopoietic cell lineage_Homo sapiens_hsa046400.54481472
112Toxoplasmosis_Homo sapiens_hsa051450.53253389
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53208063
114Galactose metabolism_Homo sapiens_hsa000520.50857053
115Insulin resistance_Homo sapiens_hsa049310.50657001
116Primary immunodeficiency_Homo sapiens_hsa053400.49450903
117Pancreatic secretion_Homo sapiens_hsa049720.48986364
118Ether lipid metabolism_Homo sapiens_hsa005650.48622143
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48010954
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.47319508
121Hepatitis C_Homo sapiens_hsa051600.46983087
122Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46128569
123Cysteine and methionine metabolism_Homo sapiens_hsa002700.46084267
124Apoptosis_Homo sapiens_hsa042100.45537380
125Tuberculosis_Homo sapiens_hsa051520.44912855
126One carbon pool by folate_Homo sapiens_hsa006700.44521857
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.42095355
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.41717078
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41072798
130Lysine degradation_Homo sapiens_hsa003100.40972174
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40576945
132Autoimmune thyroid disease_Homo sapiens_hsa053200.39680034
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36445784

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