KREMEN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.92401234
2muscle filament sliding (GO:0030049)5.61758852
3actin-myosin filament sliding (GO:0033275)5.61758852
4cardiac myofibril assembly (GO:0055003)5.59031904
5plasma membrane repair (GO:0001778)5.28814468
6myofibril assembly (GO:0030239)5.24415862
7actin-mediated cell contraction (GO:0070252)4.84037761
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.64651550
9regulation of skeletal muscle contraction (GO:0014819)4.36150349
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.26136484
11negative regulation of potassium ion transmembrane transport (GO:1901380)4.22900371
12actomyosin structure organization (GO:0031032)4.18683682
13cilium or flagellum-dependent cell motility (GO:0001539)4.12140383
14actin filament-based movement (GO:0030048)4.06700809
15cardiac cell development (GO:0055006)4.02777212
16cardiac muscle cell development (GO:0055013)3.88449790
17heart trabecula formation (GO:0060347)3.78721927
18cardiac muscle contraction (GO:0060048)3.75451165
19desmosome organization (GO:0002934)3.71412538
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68272354
21axonemal dynein complex assembly (GO:0070286)3.65929448
22glomerular visceral epithelial cell development (GO:0072015)3.60537900
23negative regulation of leukocyte chemotaxis (GO:0002689)3.59112259
24keratinization (GO:0031424)3.53395155
25behavioral response to nicotine (GO:0035095)3.52180009
26motile cilium assembly (GO:0044458)3.50109076
27hemidesmosome assembly (GO:0031581)3.49157219
28positive regulation of myotube differentiation (GO:0010831)3.48539418
29regulation of somitogenesis (GO:0014807)3.47282118
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44693449
31ventricular cardiac muscle cell action potential (GO:0086005)3.43572971
32cardiac muscle tissue morphogenesis (GO:0055008)3.42714711
33striated muscle contraction (GO:0006941)3.41186929
34establishment of skin barrier (GO:0061436)3.34695853
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.33879932
36epithelial cell-cell adhesion (GO:0090136)3.32294124
37cilium movement (GO:0003341)3.30025721
38skeletal muscle contraction (GO:0003009)3.28502717
39muscle tissue morphogenesis (GO:0060415)3.28366384
40atrioventricular valve morphogenesis (GO:0003181)3.26193011
41regulation of cardioblast differentiation (GO:0051890)3.25740734
42glomerular basement membrane development (GO:0032836)3.25320335
43regulation of p38MAPK cascade (GO:1900744)3.24433807
44cardiac muscle cell proliferation (GO:0060038)3.23171988
45glomerular epithelial cell development (GO:0072310)3.23169675
46regulation of actin filament-based movement (GO:1903115)3.22911139
47phosphatidylinositol acyl-chain remodeling (GO:0036149)3.21763594
48coronary vasculature morphogenesis (GO:0060977)3.20216451
49cell-substrate junction assembly (GO:0007044)3.20139347
50epithelial cilium movement (GO:0003351)3.17208228
51cardiac muscle hypertrophy (GO:0003300)3.12632706
52adult heart development (GO:0007512)3.10349589
53trabecula formation (GO:0060343)3.09956029
54axoneme assembly (GO:0035082)3.06684346
55striated muscle hypertrophy (GO:0014897)3.04250994
56response to inactivity (GO:0014854)2.99664559
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.98834761
58regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.97085090
59myotube differentiation (GO:0014902)2.95269362
60endocardial cushion morphogenesis (GO:0003203)2.93903113
61sarcoplasmic reticulum calcium ion transport (GO:0070296)2.93005890
62regulation of skeletal muscle cell differentiation (GO:2001014)2.92482307
63regulation of sarcomere organization (GO:0060297)2.92366692
64vascular endothelial growth factor signaling pathway (GO:0038084)2.91883916
65striated muscle atrophy (GO:0014891)2.91750030
66skeletal muscle adaptation (GO:0043501)2.91749118
67regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90261783
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.89459320
69muscle cell fate commitment (GO:0042693)2.89439182
70fibroblast migration (GO:0010761)2.88467385
71regulation of relaxation of muscle (GO:1901077)2.88441831
72carnitine shuttle (GO:0006853)2.88197886
73positive regulation of p38MAPK cascade (GO:1900745)2.81556232
74regulation of water loss via skin (GO:0033561)2.79508149
75negative regulation of heart growth (GO:0061117)2.79119871
76negative regulation of cardiac muscle tissue growth (GO:0055022)2.79119871
77collagen fibril organization (GO:0030199)2.78695035
78auditory receptor cell differentiation (GO:0042491)2.77779149
79focal adhesion assembly (GO:0048041)2.76118120
80cell-substrate adherens junction assembly (GO:0007045)2.76118120
81striated muscle cell proliferation (GO:0014855)2.75054249
82macroautophagy (GO:0016236)2.74793342
83protein heterotrimerization (GO:0070208)2.72450080
84cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72428459
85skin morphogenesis (GO:0043589)2.70644214
86aorta morphogenesis (GO:0035909)2.70190888
87adherens junction assembly (GO:0034333)2.69093535
88planar cell polarity pathway involved in neural tube closure (GO:0090179)2.66018986
89regulation of secondary heart field cardioblast proliferation (GO:0003266)2.65610672
90regulation of cardioblast proliferation (GO:0003264)2.65610672
91mesenchyme morphogenesis (GO:0072132)2.64964138
92muscle hypertrophy (GO:0014896)2.64589388
93regulation of striated muscle contraction (GO:0006942)2.63508392
94negative regulation of striated muscle cell apoptotic process (GO:0010664)2.61685682
95negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.61551314
96striated muscle adaptation (GO:0014888)2.61279942
97striated muscle cell development (GO:0055002)2.61133539
98muscle contraction (GO:0006936)2.60722050
99positive regulation of histone deacetylation (GO:0031065)2.59217212
100negative regulation of fatty acid transport (GO:2000192)2.58415947
101venous blood vessel morphogenesis (GO:0048845)2.58338508
102heart valve morphogenesis (GO:0003179)2.58313591
103muscle atrophy (GO:0014889)2.56677828
104establishment of tissue polarity (GO:0007164)2.56390631
105establishment of planar polarity (GO:0001736)2.56390631
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.55566341
107cell migration involved in sprouting angiogenesis (GO:0002042)2.55095914
108creatine metabolic process (GO:0006600)2.54329674
109phosphatidylserine acyl-chain remodeling (GO:0036150)2.53539445
110Notch signaling involved in heart development (GO:0061314)2.51651362
111fucose catabolic process (GO:0019317)2.51590271
112L-fucose metabolic process (GO:0042354)2.51590271
113L-fucose catabolic process (GO:0042355)2.51590271
114regulation of the force of heart contraction (GO:0002026)2.50915233
115pathway-restricted SMAD protein phosphorylation (GO:0060389)2.50603784
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.50476649
117cell communication involved in cardiac conduction (GO:0086065)2.49137323
118branching involved in salivary gland morphogenesis (GO:0060445)2.48585807
119glycoprotein catabolic process (GO:0006516)2.47430882
120endodermal cell differentiation (GO:0035987)2.45959224
121fatty acid transmembrane transport (GO:1902001)2.45529280
122heart morphogenesis (GO:0003007)2.45324100
123phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.45291994
124muscle cell development (GO:0055001)2.44522321
125negative regulation of Rho protein signal transduction (GO:0035024)2.39918509
126leukocyte migration involved in inflammatory response (GO:0002523)2.39841523
127keratinocyte proliferation (GO:0043616)2.39284129
128negative regulation of protein localization to cell surface (GO:2000009)2.36054644
129cornea development in camera-type eye (GO:0061303)2.32853866
130positive regulation of fatty acid oxidation (GO:0046321)2.32768057
131positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.29024355
132molting cycle (GO:0042303)2.26673262
133hair cycle (GO:0042633)2.26673262
134multicellular organismal water homeostasis (GO:0050891)2.22356529
135carnitine transmembrane transport (GO:1902603)2.22140264
136pyrimidine-containing compound transmembrane transport (GO:0072531)2.21099716
137skeletal muscle fiber development (GO:0048741)2.21064924
138skeletal muscle tissue development (GO:0007519)2.20428636
139photoreceptor cell differentiation (GO:0046530)2.19939490
140eye photoreceptor cell differentiation (GO:0001754)2.19939490
141regulation of sequestering of triglyceride (GO:0010889)2.17925256
142growth hormone receptor signaling pathway (GO:0060396)2.17743655
143lung epithelium development (GO:0060428)2.16140515
144water homeostasis (GO:0030104)2.14474519
145muscle system process (GO:0003012)2.13911176
146positive regulation of sodium ion transmembrane transport (GO:1902307)2.13215192
147positive regulation of fatty acid beta-oxidation (GO:0032000)2.11482048
148synaptic transmission, cholinergic (GO:0007271)2.10011150
149myotube cell development (GO:0014904)2.09950515
150regulation of membrane repolarization (GO:0060306)2.09312743
151regulation of action potential (GO:0098900)2.09063757
152myoblast fusion (GO:0007520)2.06451019
153positive regulation of CREB transcription factor activity (GO:0032793)2.06005712
154muscle structure development (GO:0061061)2.05799674
155negative regulation of interleukin-1 production (GO:0032692)2.05455657
156lateral sprouting from an epithelium (GO:0060601)2.05407430
157cellular response to epinephrine stimulus (GO:0071872)2.05152994
158hydrogen peroxide biosynthetic process (GO:0050665)2.05024036
159cytidine deamination (GO:0009972)2.03117712
160cytidine metabolic process (GO:0046087)2.03117712
161cytidine catabolic process (GO:0006216)2.03117712
162negative regulation of cytosolic calcium ion concentration (GO:0051481)2.02444894
163positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.02336816
164negative regulation of B cell mediated immunity (GO:0002713)2.02212681
165negative regulation of immunoglobulin mediated immune response (GO:0002890)2.02212681
166membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.02136660
167phosphatidylcholine acyl-chain remodeling (GO:0036151)2.01951501
168carnitine transport (GO:0015879)2.01914360
169amino-acid betaine transport (GO:0015838)2.01914360

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.22950376
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.23555736
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.03238425
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88270256
5EZH2_22144423_ChIP-Seq_EOC_Human2.65379885
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.57434971
7CLOCK_20551151_ChIP-Seq_293T_Human2.53455249
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46006194
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.43350019
10TBX20_22080862_ChIP-Seq_HEART_Mouse2.39552298
11TBX20_22328084_ChIP-Seq_HEART_Mouse2.39552298
12ESR2_21235772_ChIP-Seq_MCF-7_Human2.39003046
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21411431
14DROSHA_22980978_ChIP-Seq_HELA_Human2.17456595
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12934198
16ESR1_20079471_ChIP-ChIP_T-47D_Human2.03027049
17EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.01349387
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.93325136
19KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92323494
20* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.90383491
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.88507302
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79729331
23ZNF263_19887448_ChIP-Seq_K562_Human1.77617636
24ELK3_25401928_ChIP-Seq_HUVEC_Human1.77590370
25SOX9_24532713_ChIP-Seq_HFSC_Mouse1.75945662
26KDM2B_26808549_Chip-Seq_DND41_Human1.75833728
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74546476
28ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70905976
29KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.69407484
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.68992143
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67904887
32* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64162439
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.63991863
34RACK7_27058665_Chip-Seq_MCF-7_Human1.63491556
35* FOXO3_23340844_ChIP-Seq_DLD1_Human1.62401357
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.61671877
37WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60788670
38HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59215679
39PPAR_26484153_Chip-Seq_NCI-H1993_Human1.58618051
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57284185
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.54205296
42VDR_22108803_ChIP-Seq_LS180_Human1.53503922
43TCF7_22412390_ChIP-Seq_EML_Mouse1.53058839
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52735552
45RUNX1_27514584_Chip-Seq_MCF-7_Human1.50015342
46ZNF274_21170338_ChIP-Seq_K562_Hela1.49057175
47GBX2_23144817_ChIP-Seq_PC3_Human1.48770976
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48214693
49RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45485118
50CJUN_26792858_Chip-Seq_BT549_Human1.43931680
51AR_21572438_ChIP-Seq_LNCaP_Human1.43111374
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41322427
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40909116
54EZH2_27304074_Chip-Seq_ESCs_Mouse1.40828524
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.40480379
56KDM2B_26808549_Chip-Seq_K562_Human1.39364797
57PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38621724
58SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.38513359
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37611496
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37468599
61GATA1_22025678_ChIP-Seq_K562_Human1.36914459
62MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.36203561
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35593185
64LXR_22292898_ChIP-Seq_THP-1_Human1.35286359
65ATF3_27146783_Chip-Seq_COLON_Human1.32192038
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.30555533
67SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30431719
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30431719
69FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.28768934
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27537820
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.25395476
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24886254
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24559044
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.23881223
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.23853361
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.23395796
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.23067587
78CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22559821
79EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21405248
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21261938
81JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21165616
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21122861
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20626371
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20327918
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20089560
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19467725
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18184635
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.17303960
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16295370
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16178680
91ISL1_27105846_Chip-Seq_CPCs_Mouse1.14259406
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.14247834
93SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14186670
94BCAT_22108803_ChIP-Seq_LS180_Human1.14077331
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13034357
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12807255
97EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12656323
98RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12656323
99AHR_22903824_ChIP-Seq_MCF-7_Human1.12384634
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.12219259
101TP53_16413492_ChIP-PET_HCT116_Human1.10496095
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10414661
103MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09940340
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09586140
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08802892
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08802892
107RXR_22108803_ChIP-Seq_LS180_Human1.07451066
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07385446
109* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06213752
110SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05245869
111ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04607407
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04070550
113BRD4_25478319_ChIP-Seq_HGPS_Human1.03874594
114PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03809624
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02398494
116SMC1_22415368_ChIP-Seq_MEFs_Mouse1.02276962
117IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01627973
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00515328
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00201200
120BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00141933
121SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99330735
122BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98661279
123ER_23166858_ChIP-Seq_MCF-7_Human0.98638964
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.98626713
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.97509994
126REST_21632747_ChIP-Seq_MESCs_Mouse0.97480903
127LXR_22158963_ChIP-Seq_LIVER_Mouse0.97449069
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96558086
129MAF_26560356_Chip-Seq_TH1_Human0.94979611
130KLF5_25053715_ChIP-Seq_YYC3_Human0.94488165
131FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93766205
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.93324143
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92965016
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92278123
135CTCF_27219007_Chip-Seq_Bcells_Human0.92264208
136* TP63_22573176_ChIP-Seq_HFKS_Human0.92201920
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91779858
138RUNX_20019798_ChIP-Seq_JUKART_Human0.91353442
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90296226
140PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89941792
141ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89244548
142CREB1_26743006_Chip-Seq_LNCaP_Human0.89013080
143EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88221748
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.88215511
145PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88020843
146NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87757963
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87622672
148MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87603936
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.87477976
150OCT4_20526341_ChIP-Seq_ESCs_Human0.87038673
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86798694
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86763569
153* FOXA2_19822575_ChIP-Seq_HepG2_Human0.86298259
154TP53_22127205_ChIP-Seq_IMR90_Human0.86128549
155* SMAD4_21799915_ChIP-Seq_A2780_Human0.85149455
156E2F1_20622854_ChIP-Seq_HELA_Human0.84822395
157TCF4_23295773_ChIP-Seq_U87_Human0.84777643
158TP63_23658742_ChIP-Seq_EP156T_Human0.84705070
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.84664037
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.83316945
161* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82804550
162WDR5_24793694_ChIP-Seq_LNCAP_Human0.82789069
163OCT4_19829295_ChIP-Seq_ESCs_Human0.82090208
164P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81352314
165FOXH1_21741376_ChIP-Seq_ESCs_Human0.81314652
166TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81015452
167CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79839334
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79824540
169AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79765774
170EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79406708
171AR_25329375_ChIP-Seq_VCAP_Human0.79233218
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78958050
173VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78450198
174STAT3_23295773_ChIP-Seq_U87_Human0.78277739
175TCF4_22108803_ChIP-Seq_LS180_Human0.78174588
176PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77234595
177* ERA_21632823_ChIP-Seq_H3396_Human0.76971774

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.03781216
2MP0002837_dystrophic_cardiac_calcinosis4.03765726
3MP0000751_myopathy3.77551315
4MP0008438_abnormal_cutaneous_collagen3.05953744
5MP0003646_muscle_fatigue2.93851061
6MP0005275_abnormal_skin_tensile2.88310753
7MP0000749_muscle_degeneration2.88287441
8MP0004036_abnormal_muscle_relaxation2.84226076
9MP0003705_abnormal_hypodermis_morpholog2.79742193
10MP0000566_synostosis2.75779621
11MP0004381_abnormal_hair_follicle2.61910306
12MP0004087_abnormal_muscle_fiber2.55026925
13MP0003136_yellow_coat_color2.52904500
14MP0000750_abnormal_muscle_regeneration2.50494183
15MP0005330_cardiomyopathy2.40166155
16MP0004885_abnormal_endolymph2.29371587
17MP0004215_abnormal_myocardial_fiber2.26685716
18MP0004043_abnormal_pH_regulation2.24748558
19MP0005171_absent_coat_pigmentation2.23438031
20MP0003724_increased_susceptibility_to2.10463392
21MP0010630_abnormal_cardiac_muscle2.10288036
22MP0000733_abnormal_muscle_development2.04350711
23MP0002106_abnormal_muscle_physiology2.02093386
24MP0002972_abnormal_cardiac_muscle2.01893508
25MP0004145_abnormal_muscle_electrophysio1.97868340
26MP0003279_aneurysm1.91098365
27MP0002653_abnormal_ependyma_morphology1.89004445
28MP0005377_hearing/vestibular/ear_phenot1.86240552
29MP0003878_abnormal_ear_physiology1.86240552
30MP0003828_pulmonary_edema1.82970908
31MP0003566_abnormal_cell_adhesion1.82310684
32MP0004272_abnormal_basement_membrane1.82244201
33MP0005620_abnormal_muscle_contractility1.80485104
34MP0003011_delayed_dark_adaptation1.79230026
35MP0001544_abnormal_cardiovascular_syste1.78641414
36MP0005385_cardiovascular_system_phenoty1.78641414
37MP0008775_abnormal_heart_ventricle1.76712332
38MP0000759_abnormal_skeletal_muscle1.75626676
39MP0005369_muscle_phenotype1.73722378
40MP0006138_congestive_heart_failure1.72353084
41MP0002638_abnormal_pupillary_reflex1.72133884
42MP0004130_abnormal_muscle_cell1.71385486
43MP0000747_muscle_weakness1.70499220
44MP0003941_abnormal_skin_development1.69062610
45MP0002269_muscular_atrophy1.68820492
46MP0005623_abnormal_meninges_morphology1.67492475
47MP0000372_irregular_coat_pigmentation1.65668720
48MP0005503_abnormal_tendon_morphology1.64213253
49MP0000427_abnormal_hair_cycle1.60139346
50MP0002277_abnormal_respiratory_mucosa1.59944400
51MP0010368_abnormal_lymphatic_system1.53702720
52MP0003283_abnormal_digestive_organ1.50097153
53MP0001849_ear_inflammation1.49678089
54MP0009384_cardiac_valve_regurgitation1.45580249
55MP0004510_myositis1.42718729
56MP0002095_abnormal_skin_pigmentation1.42544692
57MP0000767_abnormal_smooth_muscle1.42353800
58MP0002098_abnormal_vibrissa_morphology1.37831909
59MP0002060_abnormal_skin_morphology1.36646684
60MP0003195_calcinosis1.34878042
61MP0001958_emphysema1.33688955
62MP0004185_abnormal_adipocyte_glucose1.32635380
63MP0002108_abnormal_muscle_morphology1.32599217
64MP0003137_abnormal_impulse_conducting1.32456133
65MP0004233_abnormal_muscle_weight1.29774589
66MP0004484_altered_response_of1.28457485
67MP0005666_abnormal_adipose_tissue1.23379469
68MP0002234_abnormal_pharynx_morphology1.22588613
69MP0005167_abnormal_blood-brain_barrier1.22137272
70MP0009780_abnormal_chondrocyte_physiolo1.20529179
71MP0004858_abnormal_nervous_system1.20121299
72MP0000383_abnormal_hair_follicle1.19153022
73MP0006054_spinal_hemorrhage1.18900372
74MP0000579_abnormal_nail_morphology1.18158536
75MP0002332_abnormal_exercise_endurance1.16251187
76MP0005508_abnormal_skeleton_morphology1.14391384
77MP0002796_impaired_skin_barrier1.13577267
78MP0010030_abnormal_orbit_morphology1.13265623
79MP0010234_abnormal_vibrissa_follicle1.11473378
80MP0001879_abnormal_lymphatic_vessel1.10586556
81MP0005409_darkened_coat_color1.09690859
82MP0005023_abnormal_wound_healing1.09265218
83MP0002876_abnormal_thyroid_physiology1.06440048
84MP0000015_abnormal_ear_pigmentation1.05484562
85MP0005375_adipose_tissue_phenotype1.05450905
86MP0002877_abnormal_melanocyte_morpholog1.05106905
87MP0002127_abnormal_cardiovascular_syste1.03294859
88MP0010678_abnormal_skin_adnexa1.03043344
89MP0003567_abnormal_fetal_cardiomyocyte1.00215381
90MP0002128_abnormal_blood_circulation0.99643040
91MP0000266_abnormal_heart_morphology0.98492122
92MP0005075_abnormal_melanosome_morpholog0.97547140
93MP0005248_abnormal_Harderian_gland0.97538464
94MP0000762_abnormal_tongue_morphology0.97491620
95MP0004085_abnormal_heartbeat0.97470842
96MP0003879_abnormal_hair_cell0.97376949
97MP0003045_fibrosis0.96602821
98MP0008875_abnormal_xenobiotic_pharmacok0.96534085
99MP0003950_abnormal_plasma_membrane0.95862680
100MP0005076_abnormal_cell_differentiation0.95190108
101MP0001324_abnormal_eye_pigmentation0.95104749
102MP0000377_abnormal_hair_follicle0.93425830
103MP0000467_abnormal_esophagus_morphology0.93130086
104MP0009278_abnormal_bone_marrow0.92268439
105MP0002938_white_spotting0.91345569
106MP0000470_abnormal_stomach_morphology0.90942494
107MP0005670_abnormal_white_adipose0.90645133
108MP0003221_abnormal_cardiomyocyte_apopto0.90526796
109MP0003453_abnormal_keratinocyte_physiol0.89811646
110MP0000003_abnormal_adipose_tissue0.88141599
111MP0003300_gastrointestinal_ulcer0.86443427
112MP0003091_abnormal_cell_migration0.85769984
113MP0001299_abnormal_eye_distance/0.84636696
114MP0002896_abnormal_bone_mineralization0.84365740
115MP0002925_abnormal_cardiovascular_devel0.83009646
116MP0005174_abnormal_tail_pigmentation0.82251571
117MP0000428_abnormal_craniofacial_morphol0.81793357
118MP0000678_abnormal_parathyroid_gland0.81413847
119MP0002166_altered_tumor_susceptibility0.80230284
120MP0002282_abnormal_trachea_morphology0.78597931
121MP0000013_abnormal_adipose_tissue0.78560089
122MP0010352_gastrointestinal_tract_polyps0.78249053
123MP0000534_abnormal_ureter_morphology0.77045571
124MP0005551_abnormal_eye_electrophysiolog0.76837788
125MP0003122_maternal_imprinting0.76369280
126MP0001614_abnormal_blood_vessel0.75548657
127MP0001243_abnormal_dermal_layer0.75046637
128MP0002933_joint_inflammation0.74956743
129MP0002132_abnormal_respiratory_system0.74602523
130MP0003115_abnormal_respiratory_system0.74526263
131MP0002932_abnormal_joint_morphology0.74399019
132MP0004270_analgesia0.73437690
133MP0004142_abnormal_muscle_tone0.71285299
134MP0002909_abnormal_adrenal_gland0.70365288
135MP0002249_abnormal_larynx_morphology0.69966121
136MP0000343_altered_response_to0.69436496
137MP0010771_integument_phenotype0.68667859
138MP0001485_abnormal_pinna_reflex0.68379702
139MP0002168_other_aberrant_phenotype0.67998112
140MP0001984_abnormal_olfaction0.67701498
141MP0005083_abnormal_biliary_tract0.65994077
142MP0000647_abnormal_sebaceous_gland0.65912074
143MP0004133_heterotaxia0.65685071
144MP0001533_abnormal_skeleton_physiology0.65468749
145MP0003938_abnormal_ear_development0.65408574
146MP0003942_abnormal_urinary_system0.64929199
147MP0001784_abnormal_fluid_regulation0.64360042
148MP0004947_skin_inflammation0.63905129
149MP0001188_hyperpigmentation0.63575549
150MP0001765_abnormal_ion_homeostasis0.63416654
151MP0008961_abnormal_basal_metabolism0.63265390
152MP0001664_abnormal_digestion0.62917539
153MP0000026_abnormal_inner_ear0.62162786
154MP0001270_distended_abdomen0.61508603

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)5.24188848
2Sudden death (HP:0001699)4.87443595
3Type 1 muscle fiber predominance (HP:0003803)4.69634461
4Right ventricular cardiomyopathy (HP:0011663)4.59856161
5Hyporeflexia of lower limbs (HP:0002600)4.59372778
6Increased connective tissue (HP:0009025)4.50851844
7Ventricular tachycardia (HP:0004756)4.47574783
8Abnormality of the calf musculature (HP:0001430)4.29250176
9Calf muscle hypertrophy (HP:0008981)4.15467435
10Exercise-induced muscle cramps (HP:0003710)3.94192969
11Exercise-induced myalgia (HP:0003738)3.86645772
12Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.82782828
13Muscle fiber inclusion bodies (HP:0100299)3.81159987
14Absent/shortened dynein arms (HP:0200106)3.75198916
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.75198916
16Muscle hypertrophy of the lower extremities (HP:0008968)3.69859689
17Abnormality of the left ventricular outflow tract (HP:0011103)3.58737280
18Subaortic stenosis (HP:0001682)3.58737280
19Hypoplastic ischia (HP:0003175)3.55395048
20Difficulty running (HP:0009046)3.48355627
21Abnormal respiratory motile cilium morphology (HP:0005938)3.45135699
22Abnormal respiratory epithelium morphology (HP:0012253)3.45135699
23Premature rupture of membranes (HP:0001788)3.44696282
24EMG: myopathic abnormalities (HP:0003458)3.44172586
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.42929016
26Difficulty climbing stairs (HP:0003551)3.41721449
27Protrusio acetabuli (HP:0003179)3.38394317
28Lipoatrophy (HP:0100578)3.33901559
29Atrial fibrillation (HP:0005110)3.32999172
30Mildly elevated creatine phosphokinase (HP:0008180)3.32271019
31Abnormal ciliary motility (HP:0012262)3.24028980
32Absent phalangeal crease (HP:0006109)3.18410901
33Primary atrial arrhythmia (HP:0001692)3.07885909
34Abnormality of the ischium (HP:0003174)3.06289995
35Nemaline bodies (HP:0003798)3.01029996
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.93966690
37Broad metatarsal (HP:0001783)2.92889227
38Fetal akinesia sequence (HP:0001989)2.91931340
39Supraventricular arrhythmia (HP:0005115)2.91473347
40Supraventricular tachycardia (HP:0004755)2.90648469
41Asymmetric septal hypertrophy (HP:0001670)2.88450920
42Cerebral aneurysm (HP:0004944)2.85352242
43Distal lower limb muscle weakness (HP:0009053)2.84526701
44Abnormal respiratory motile cilium physiology (HP:0012261)2.81424462
45Calcaneovalgus deformity (HP:0001848)2.81217202
46Myoglobinuria (HP:0002913)2.77682932
47Scapular winging (HP:0003691)2.76894272
48Increased variability in muscle fiber diameter (HP:0003557)2.76723433
49Abnormality of skeletal muscle fiber size (HP:0012084)2.75239788
50Dilated cardiomyopathy (HP:0001644)2.74112872
51Distal lower limb amyotrophy (HP:0008944)2.72798072
52Round ear (HP:0100830)2.69333702
53Bundle branch block (HP:0011710)2.63796642
54Increased IgE level (HP:0003212)2.62291991
55Ankle contracture (HP:0006466)2.56953051
56Aortic dissection (HP:0002647)2.56900526
57Abnormal finger flexion creases (HP:0006143)2.56118646
58Atrophic scars (HP:0001075)2.54469609
59Hypotrichosis (HP:0001006)2.54300543
60Spinal rigidity (HP:0003306)2.53992828
61Hip contracture (HP:0003273)2.52399797
62Deformed tarsal bones (HP:0008119)2.50178091
63Pancreatic cysts (HP:0001737)2.49690360
64Aplasia of the musculature (HP:0100854)2.48110224
65Abnormality of midbrain morphology (HP:0002418)2.47908338
66Molar tooth sign on MRI (HP:0002419)2.47908338
67Hyperkalemia (HP:0002153)2.47637424
68Syncope (HP:0001279)2.45642793
69Shallow orbits (HP:0000586)2.42962996
70Hypoplastic nipples (HP:0002557)2.41851038
71True hermaphroditism (HP:0010459)2.39680769
72Decreased circulating renin level (HP:0003351)2.36789564
73Ventricular arrhythmia (HP:0004308)2.36268565
74Type II lissencephaly (HP:0007260)2.35451486
75Ulnar deviation of the wrist (HP:0003049)2.33943699
76Distal arthrogryposis (HP:0005684)2.33261742
77Abnormality of the neuromuscular junction (HP:0003398)2.30989694
78Fatigable weakness (HP:0003473)2.30989694
79Rhinitis (HP:0012384)2.30122224
80Abnormal atrioventricular conduction (HP:0005150)2.29888978
81Limb-girdle muscle atrophy (HP:0003797)2.28949217
82Prolonged QT interval (HP:0001657)2.28410160
83Furrowed tongue (HP:0000221)2.27490925
84Nephronophthisis (HP:0000090)2.26329555
85Atrioventricular block (HP:0001678)2.25007858
86Orchitis (HP:0100796)2.20582412
87Pancreatic fibrosis (HP:0100732)2.19762442
88Heart block (HP:0012722)2.17306163
89Fragile skin (HP:0001030)2.15591334
90Increased corneal curvature (HP:0100692)2.14480555
91Keratoconus (HP:0000563)2.14480555
92Retrobulbar optic neuritis (HP:0100654)2.11916432
93Optic neuritis (HP:0100653)2.11916432
94Aortic aneurysm (HP:0004942)2.11896048
95Keratoconjunctivitis (HP:0001096)2.11251997
96Mesangial abnormality (HP:0001966)2.08828067
97Bell-shaped thorax (HP:0001591)2.08635327
98Occipital encephalocele (HP:0002085)2.08295273
99Aneurysm (HP:0002617)2.06897141
100Concave nail (HP:0001598)2.05966452
101Tubular atrophy (HP:0000092)2.05082702
102Neck muscle weakness (HP:0000467)2.04791104
103Generalized muscle weakness (HP:0003324)2.02672213
104Myotonia (HP:0002486)2.02156711
105Nasal polyposis (HP:0100582)2.02152573
106Palmoplantar hyperkeratosis (HP:0000972)2.01951109
107Hyperventilation (HP:0002883)2.01704892
108Myositis (HP:0100614)2.01510692
109Keratoconjunctivitis sicca (HP:0001097)2.00532754
110Abnormality of nail color (HP:0100643)2.00059859
111Malignant hyperthermia (HP:0002047)1.97982459
112Abnormality of the pubic bones (HP:0003172)1.97257195
113Palpitations (HP:0001962)1.95538757
114Gowers sign (HP:0003391)1.95536853
115Lower limb amyotrophy (HP:0007210)1.95509260
116Rhabdomyolysis (HP:0003201)1.95280006
117Congenital sensorineural hearing impairment (HP:0008527)1.92434326
118Exostoses (HP:0100777)1.92038798
119Myopathic facies (HP:0002058)1.91755493
120Mitral valve prolapse (HP:0001634)1.91603807
121Woolly hair (HP:0002224)1.90002216
122Cystic liver disease (HP:0006706)1.89912508
123Weak cry (HP:0001612)1.88946756
124Alopecia of scalp (HP:0002293)1.88807280
125Abnormality of the renal medulla (HP:0100957)1.88663047
126Frequent falls (HP:0002359)1.88474293
127Pterygium (HP:0001059)1.88406100
128Nonprogressive disorder (HP:0003680)1.88238619
129Limited hip movement (HP:0008800)1.87721635
130Ventricular fibrillation (HP:0001663)1.87517007
131Type 2 muscle fiber atrophy (HP:0003554)1.86957928
132Knee flexion contracture (HP:0006380)1.86295614
133EMG: neuropathic changes (HP:0003445)1.85403547
134Facial diplegia (HP:0001349)1.85308461
135Abnormality of the labia majora (HP:0012881)1.82189213
136Cervical subluxation (HP:0003308)1.81794731
137Abnormal vertebral ossification (HP:0100569)1.81077725
138Conjunctival hamartoma (HP:0100780)1.80920770
139Lymphangioma (HP:0100764)1.80771032
140Milia (HP:0001056)1.79788150
141Blue irides (HP:0000635)1.79544851
142Peritonitis (HP:0002586)1.78589559
143Muscular dystrophy (HP:0003560)1.77764580
144Palmar hyperkeratosis (HP:0010765)1.77564425
145Bladder diverticulum (HP:0000015)1.77018777
146Popliteal pterygium (HP:0009756)1.76550642
147Arterial tortuosity (HP:0005116)1.75555647
148Dilatation of the ascending aorta (HP:0005111)1.74662031
149Palmoplantar keratoderma (HP:0000982)1.74640307
150Proximal amyotrophy (HP:0007126)1.73452188
151Abnormality of the axillary hair (HP:0100134)1.72342575
152Abnormality of secondary sexual hair (HP:0009888)1.72342575
153Unilateral renal agenesis (HP:0000122)1.69816890
154Abnormality of the nasal mucosa (HP:0000433)1.69622429
155Sudden cardiac death (HP:0001645)1.69585254
156Oligodontia (HP:0000677)1.69319440
157Elbow flexion contracture (HP:0002987)1.68288298
158Gastrointestinal infarctions (HP:0005244)1.68151156
159Slender build (HP:0001533)1.65961467

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.79431077
2TRIB34.49928222
3DDR23.65276462
4PKN23.53366792
5OBSCN3.21698945
6FRK3.13971579
7DMPK2.72482694
8LATS12.35747758
9MAP2K62.17721464
10PINK12.12282212
11RIPK12.04471388
12PDGFRA1.91143455
13LMTK21.91004760
14SIK11.88537812
15TGFBR21.87883502
16FGFR41.84275843
17MAPK151.82936561
18EPHB11.81061266
19ADRBK21.76030501
20TRPM71.75009735
21EEF2K1.74689505
22PTK61.74585742
23PHKG21.73625720
24PHKG11.73625720
25WNK41.65842257
26MAP3K71.64578501
27MYLK1.50667736
28MAP3K101.50261563
29ERN11.44418246
30MUSK1.43796908
31GRK11.39412498
32MAPKAPK31.36595096
33FGFR31.35613176
34EPHA31.29929335
35DAPK21.28130110
36PDK31.27036387
37PDK41.27036387
38IRAK11.26853018
39NME11.24944310
40BMPR1B1.21495206
41MAP3K31.21416491
42ACVR1B1.20075829
43PTK2B1.14734855
44MAP3K61.13250101
45EPHB21.12626414
46ADRBK11.08476450
47NEK11.07098350
48LRRK21.05252367
49MOS1.04928306
50CASK1.03715603
51PIK3CG1.03522475
52MAP2K41.02166384
53PDGFRB1.02043120
54MAP2K31.00680211
55TIE11.00559846
56ILK0.99160623
57TLK10.98417425
58IRAK40.96842510
59TGFBR10.96297642
60PAK30.95894951
61CSK0.94600923
62TNK20.94368715
63PRKD10.94202922
64MAPK130.93694872
65FER0.92167721
66PIK3CA0.91564943
67MTOR0.90361960
68MARK10.89711603
69PAK40.89001175
70ROCK10.88799153
71MAP3K20.83437866
72PDK20.83105667
73TXK0.82124060
74WNK10.81563197
75NTRK30.81501676
76STK390.80096481
77DYRK1B0.77769187
78SIK20.77296402
79AKT30.74982587
80FGFR10.74009192
81STK100.72640778
82PRKCZ0.70715805
83PTK20.70091238
84JAK10.69039788
85GRK60.69031647
86OXSR10.66914505
87BMX0.66805919
88MAPK120.66132743
89STK110.64161803
90PAK20.63017230
91TYK20.62836172
92STK38L0.62367153
93FLT30.62056851
94PDPK10.60821522
95CDK60.60307874
96RET0.59386514
97CDK120.59247271
98ICK0.59185389
99LATS20.59157102
100BCKDK0.58658414
101TAOK30.56951520
102STK30.56868451
103CAMK10.56631640
104KIT0.55136702
105TAOK10.54399681
106ERBB20.54125373
107PRKCH0.53683919
108TNIK0.53312579
109CDC42BPA0.52788227
110RPS6KC10.51962990
111RPS6KL10.51962990
112ROCK20.51702453
113JAK30.51549555
114MAP3K10.51038436
115PRKD30.50755125
116RPS6KA60.50367426
117RPS6KB20.49288796
118FGFR20.48694187
119NLK0.46380484
120MAPK70.46151533
121NEK90.45452209
122PDK10.44548322
123MARK30.44423078
124MAP4K20.43821949
125SGK4940.43384701
126SGK2230.43384701
127MAP2K10.42992240
128SGK10.42624778
129EPHA20.42517793
130HIPK20.42381803
131MATK0.42287590
132PRKAA20.41954523
133AKT20.41251598
134JAK20.40940213
135PRKD20.40784679
136MAPKAPK20.40583811
137CHUK0.40424844
138STK40.39858882
139ZAP700.39764131
140MARK20.38767796
141STK380.38622144
142PRKAA10.36484669
143CAMK40.36226441
144RPS6KA10.35483198
145MET0.34895856
146MST1R0.34872735
147MAP3K50.34519770
148INSRR0.33666419

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.45744835
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.45101002
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.10726224
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.07197417
5Linoleic acid metabolism_Homo sapiens_hsa005912.64187949
6ECM-receptor interaction_Homo sapiens_hsa045122.55002851
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52021230
8Nitrogen metabolism_Homo sapiens_hsa009102.21071841
9Focal adhesion_Homo sapiens_hsa045102.20008932
10Viral myocarditis_Homo sapiens_hsa054162.09819343
11Histidine metabolism_Homo sapiens_hsa003402.00753444
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.00630723
13Adherens junction_Homo sapiens_hsa045201.89477555
14Notch signaling pathway_Homo sapiens_hsa043301.83473352
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77594925
16Phototransduction_Homo sapiens_hsa047441.72012903
17ABC transporters_Homo sapiens_hsa020101.71769595
18Proteoglycans in cancer_Homo sapiens_hsa052051.68400423
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.59901931
20Ether lipid metabolism_Homo sapiens_hsa005651.59405926
21AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.56741353
22Amoebiasis_Homo sapiens_hsa051461.55797778
23Basal cell carcinoma_Homo sapiens_hsa052171.54130772
24Fatty acid degradation_Homo sapiens_hsa000711.52622302
25Insulin resistance_Homo sapiens_hsa049311.51732457
26Small cell lung cancer_Homo sapiens_hsa052221.50221141
27Cardiac muscle contraction_Homo sapiens_hsa042601.45793640
28Chronic myeloid leukemia_Homo sapiens_hsa052201.45653197
29Lysine degradation_Homo sapiens_hsa003101.44797313
30Protein digestion and absorption_Homo sapiens_hsa049741.44390237
31Ovarian steroidogenesis_Homo sapiens_hsa049131.39603525
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36688987
33Hippo signaling pathway_Homo sapiens_hsa043901.33964316
34Arachidonic acid metabolism_Homo sapiens_hsa005901.33439618
35Calcium signaling pathway_Homo sapiens_hsa040201.32891212
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.30471765
37Gastric acid secretion_Homo sapiens_hsa049711.26370671
38Adipocytokine signaling pathway_Homo sapiens_hsa049201.25232752
39Dorso-ventral axis formation_Homo sapiens_hsa043201.24815292
40Toxoplasmosis_Homo sapiens_hsa051451.22995928
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20545786
42Tight junction_Homo sapiens_hsa045301.16287317
43Staphylococcus aureus infection_Homo sapiens_hsa051501.15624354
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12190306
45Glycerophospholipid metabolism_Homo sapiens_hsa005641.11784774
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11151567
47Fatty acid biosynthesis_Homo sapiens_hsa000611.10705094
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09439216
49Insulin signaling pathway_Homo sapiens_hsa049101.09238101
50Mineral absorption_Homo sapiens_hsa049781.08789494
51Propanoate metabolism_Homo sapiens_hsa006401.08428935
52Bladder cancer_Homo sapiens_hsa052191.08428930
53MicroRNAs in cancer_Homo sapiens_hsa052061.07950929
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.03175343
55Insulin secretion_Homo sapiens_hsa049111.02615784
56Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02569761
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00898442
58Tryptophan metabolism_Homo sapiens_hsa003801.00540687
59Circadian entrainment_Homo sapiens_hsa047130.98767572
60Regulation of actin cytoskeleton_Homo sapiens_hsa048100.96607268
61TGF-beta signaling pathway_Homo sapiens_hsa043500.96334170
62Fatty acid metabolism_Homo sapiens_hsa012120.95922776
63beta-Alanine metabolism_Homo sapiens_hsa004100.94236726
64Salivary secretion_Homo sapiens_hsa049700.94105770
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93914009
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93717892
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93327852
68Fat digestion and absorption_Homo sapiens_hsa049750.91270831
69Endometrial cancer_Homo sapiens_hsa052130.90591429
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90156988
71Renal cell carcinoma_Homo sapiens_hsa052110.89074276
72Acute myeloid leukemia_Homo sapiens_hsa052210.88437366
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88036556
74Phenylalanine metabolism_Homo sapiens_hsa003600.87831408
75HIF-1 signaling pathway_Homo sapiens_hsa040660.87761895
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.87740954
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87676049
78Vitamin digestion and absorption_Homo sapiens_hsa049770.87604432
79Glucagon signaling pathway_Homo sapiens_hsa049220.86635400
80FoxO signaling pathway_Homo sapiens_hsa040680.86202934
81Caffeine metabolism_Homo sapiens_hsa002320.86014556
82Butanoate metabolism_Homo sapiens_hsa006500.85644891
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.84892568
84cAMP signaling pathway_Homo sapiens_hsa040240.84692161
85Pancreatic cancer_Homo sapiens_hsa052120.84204903
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.83813029
87Osteoclast differentiation_Homo sapiens_hsa043800.80258225
88Platelet activation_Homo sapiens_hsa046110.80120573
89Bile secretion_Homo sapiens_hsa049760.79119341
90TNF signaling pathway_Homo sapiens_hsa046680.79090674
91HTLV-I infection_Homo sapiens_hsa051660.79056185
92mTOR signaling pathway_Homo sapiens_hsa041500.78352134
93Pathways in cancer_Homo sapiens_hsa052000.78095112
94PPAR signaling pathway_Homo sapiens_hsa033200.78049870
95Renin secretion_Homo sapiens_hsa049240.77503207
96Carbon metabolism_Homo sapiens_hsa012000.77098077
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76347681
98VEGF signaling pathway_Homo sapiens_hsa043700.75008729
99Starch and sucrose metabolism_Homo sapiens_hsa005000.73936483
100Tyrosine metabolism_Homo sapiens_hsa003500.73693264
101Serotonergic synapse_Homo sapiens_hsa047260.73679546
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73100436
103Glycerolipid metabolism_Homo sapiens_hsa005610.72536405
104AMPK signaling pathway_Homo sapiens_hsa041520.72417762
105Olfactory transduction_Homo sapiens_hsa047400.72261782
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72103989
107Arginine and proline metabolism_Homo sapiens_hsa003300.71243642
108Axon guidance_Homo sapiens_hsa043600.70952690
109Long-term depression_Homo sapiens_hsa047300.70840069
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70539250
111Type II diabetes mellitus_Homo sapiens_hsa049300.70465119
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69934992
113Prostate cancer_Homo sapiens_hsa052150.69304117
114Prolactin signaling pathway_Homo sapiens_hsa049170.68474156
115Chemical carcinogenesis_Homo sapiens_hsa052040.67602763
116Wnt signaling pathway_Homo sapiens_hsa043100.65475042
117T cell receptor signaling pathway_Homo sapiens_hsa046600.64901055
118Hedgehog signaling pathway_Homo sapiens_hsa043400.64890285
119Melanogenesis_Homo sapiens_hsa049160.64496202
120Malaria_Homo sapiens_hsa051440.64254808
121Glutamatergic synapse_Homo sapiens_hsa047240.64165269
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63996177
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63900469
124Thyroid cancer_Homo sapiens_hsa052160.63703904
125Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63084698
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.62832243
127Pancreatic secretion_Homo sapiens_hsa049720.62796838
128Leishmaniasis_Homo sapiens_hsa051400.62624309
129Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61210296
130Rap1 signaling pathway_Homo sapiens_hsa040150.60668656
131Cholinergic synapse_Homo sapiens_hsa047250.59743057
132Melanoma_Homo sapiens_hsa052180.59340255
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57788273
134Taste transduction_Homo sapiens_hsa047420.57412475
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.57036737
136Choline metabolism in cancer_Homo sapiens_hsa052310.56611716
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55076626
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.53531500
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52328325
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.52180421
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.52081627
142Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51933410
143Glioma_Homo sapiens_hsa052140.51658644
144Estrogen signaling pathway_Homo sapiens_hsa049150.51137260
145Cocaine addiction_Homo sapiens_hsa050300.50479653
146Morphine addiction_Homo sapiens_hsa050320.50076423
147Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49284946
148Non-small cell lung cancer_Homo sapiens_hsa052230.49157773
149Colorectal cancer_Homo sapiens_hsa052100.48980778
150Primary immunodeficiency_Homo sapiens_hsa053400.48116246
151MAPK signaling pathway_Homo sapiens_hsa040100.47309786
152Salmonella infection_Homo sapiens_hsa051320.45757061
153Oxytocin signaling pathway_Homo sapiens_hsa049210.45433298
154Circadian rhythm_Homo sapiens_hsa047100.45187734
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44494779
156Regulation of autophagy_Homo sapiens_hsa041400.44324208
157Hepatitis B_Homo sapiens_hsa051610.43568962
158Apoptosis_Homo sapiens_hsa042100.43552618
159Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43374141
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.42958833
161Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42642409
162Dopaminergic synapse_Homo sapiens_hsa047280.42327107
163Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39202352
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.37667392
165Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35445803
166GnRH signaling pathway_Homo sapiens_hsa049120.35328221

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