KREMEN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.02051945
2proline biosynthetic process (GO:0006561)5.00282655
3regulation of translational fidelity (GO:0006450)4.23494780
4mitotic chromosome condensation (GO:0007076)4.22984653
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.12206179
6COPI coating of Golgi vesicle (GO:0048205)4.11485372
7Golgi transport vesicle coating (GO:0048200)4.11485372
8peptidyl-arginine omega-N-methylation (GO:0035247)4.01963980
9superoxide anion generation (GO:0042554)4.00812711
10spliceosomal tri-snRNP complex assembly (GO:0000244)3.90571820
11regulation of nuclear cell cycle DNA replication (GO:0033262)3.82627139
12positive regulation of Cdc42 GTPase activity (GO:0043089)3.79389112
13DNA strand elongation involved in DNA replication (GO:0006271)3.69208130
14DNA strand elongation (GO:0022616)3.66303017
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.65341963
16maternal placenta development (GO:0001893)3.62024869
17proline metabolic process (GO:0006560)3.61604921
18detection of bacterium (GO:0016045)3.58793999
19detection of other organism (GO:0098543)3.57106046
20planar cell polarity pathway involved in neural tube closure (GO:0090179)3.56162550
21negative regulation of cell size (GO:0045792)3.55599414
22histone arginine methylation (GO:0034969)3.54901812
23DNA replication initiation (GO:0006270)3.47181797
24protein complex localization (GO:0031503)3.46062582
25GDP-mannose metabolic process (GO:0019673)3.46061807
26apoptotic process involved in morphogenesis (GO:0060561)3.43991184
27mitotic G1 DNA damage checkpoint (GO:0031571)3.43659942
28desmosome organization (GO:0002934)3.42459854
29ribosomal small subunit biogenesis (GO:0042274)3.34876956
30mesenchymal cell differentiation involved in kidney development (GO:0072161)3.33415496
31mesenchymal cell differentiation involved in renal system development (GO:2001012)3.33415496
32replicative senescence (GO:0090399)3.32305619
33DNA duplex unwinding (GO:0032508)3.29938476
34activation of Rac GTPase activity (GO:0032863)3.29745797
35negative regulation of keratinocyte proliferation (GO:0010839)3.29474889
36formation of translation preinitiation complex (GO:0001731)3.28372228
37viral mRNA export from host cell nucleus (GO:0046784)3.27044617
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.26934071
39ear development (GO:0043583)3.26822827
40regulation of glucose import in response to insulin stimulus (GO:2001273)3.26374428
41heterochromatin organization (GO:0070828)3.25080066
42peptidyl-arginine N-methylation (GO:0035246)3.22768595
43peptidyl-arginine methylation (GO:0018216)3.22768595
44adherens junction assembly (GO:0034333)3.21286663
45regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.20517955
46regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.19770087
47cell-substrate adherens junction assembly (GO:0007045)3.18401193
48focal adhesion assembly (GO:0048041)3.18401193
49keratinocyte development (GO:0003334)3.17889247
50negative regulation of mast cell activation (GO:0033004)3.17106495
51positive regulation of cellular amide metabolic process (GO:0034250)3.13471797
52protein localization to chromosome, centromeric region (GO:0071459)3.08687914
53DNA geometric change (GO:0032392)3.07443564
54regulation of chromatin binding (GO:0035561)3.07138266
55DNA strand renaturation (GO:0000733)3.06785662
56G1 DNA damage checkpoint (GO:0044783)3.06056063
57nuclear pore complex assembly (GO:0051292)3.05670594
58centriole assembly (GO:0098534)3.05048440
59tRNA methylation (GO:0030488)3.05010818
60regulation of dendritic cell antigen processing and presentation (GO:0002604)3.04172480
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03181448
62rRNA transcription (GO:0009303)3.03150504
63nucleosome disassembly (GO:0006337)3.02067179
64protein-DNA complex disassembly (GO:0032986)3.02067179
65cellular protein complex localization (GO:0034629)3.01789556
66telomere maintenance via semi-conservative replication (GO:0032201)3.00647902
67intracellular estrogen receptor signaling pathway (GO:0030520)3.00061220
68establishment of apical/basal cell polarity (GO:0035089)2.99649394
69mitotic G1/S transition checkpoint (GO:0044819)2.98902247
70negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98245064
71semaphorin-plexin signaling pathway (GO:0071526)2.94287188
72snRNA metabolic process (GO:0016073)2.92834167
73protein retention in ER lumen (GO:0006621)2.92201815
74mitotic sister chromatid segregation (GO:0000070)2.91203809
75folic acid metabolic process (GO:0046655)2.87113184
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.84669412
77energy homeostasis (GO:0097009)2.83799831
78regulation of RIG-I signaling pathway (GO:0039535)2.83375689
79regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.82768072
80L-serine metabolic process (GO:0006563)2.82040538
81DNA synthesis involved in DNA repair (GO:0000731)2.80403820
82positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.80299403
83maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.79802885
84cornea development in camera-type eye (GO:0061303)2.78634475
85negative regulation of myoblast differentiation (GO:0045662)2.76377213
86establishment of skin barrier (GO:0061436)2.75846141
87mitochondrial fusion (GO:0008053)2.75112834
88DNA topological change (GO:0006265)2.74891853
89chromosome condensation (GO:0030261)2.74618168
90dendritic cell chemotaxis (GO:0002407)2.74490959
91pentose-phosphate shunt (GO:0006098)2.74115779
92adenine nucleotide transport (GO:0051503)2.72504632
93limb bud formation (GO:0060174)2.72200148
94regulation of male gonad development (GO:2000018)2.72024926
95DNA conformation change (GO:0071103)2.71512997
96termination of RNA polymerase III transcription (GO:0006386)2.71379786
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.71379786
98branching involved in mammary gland duct morphogenesis (GO:0060444)2.70319508
99RNA stabilization (GO:0043489)2.70036319
100mRNA stabilization (GO:0048255)2.70036319
101regulation of histone H3-K27 methylation (GO:0061085)2.66622612
102chromatin assembly (GO:0031497)2.66470153
103convergent extension (GO:0060026)2.62468191
104peptidyl-lysine dimethylation (GO:0018027)2.61995528
105regulation of translational termination (GO:0006449)2.61829487
106NIK/NF-kappaB signaling (GO:0038061)2.61590050
107female gonad development (GO:0008585)2.61322895
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61022159
109L-alpha-amino acid transmembrane transport (GO:1902475)2.59030932
110maturation of SSU-rRNA (GO:0030490)2.58600701
111epithelial cell-cell adhesion (GO:0090136)2.56730866
112response to peptidoglycan (GO:0032494)2.55939298
113DNA replication checkpoint (GO:0000076)2.54763344
114nuclear envelope reassembly (GO:0031468)2.54433107
115mitotic nuclear envelope reassembly (GO:0007084)2.54433107
116sister chromatid segregation (GO:0000819)2.54080748
117mitotic sister chromatid cohesion (GO:0007064)2.53806272
118negative regulation of viral release from host cell (GO:1902187)2.53712233
119positive regulation of antigen processing and presentation (GO:0002579)2.53066946
120sympathetic nervous system development (GO:0048485)2.52590326
121mRNA cleavage (GO:0006379)2.51839442
122mammary gland epithelial cell differentiation (GO:0060644)2.51142968
123ganglion development (GO:0061548)2.49674429
124cyclooxygenase pathway (GO:0019371)2.48244719
125cell differentiation involved in embryonic placenta development (GO:0060706)2.48235221
126negative regulation of cell fate specification (GO:0009996)2.46867277
127ribosome biogenesis (GO:0042254)2.45581716
128regulation of cell proliferation involved in kidney development (GO:1901722)2.45388060
129glucose 6-phosphate metabolic process (GO:0051156)2.45269836
130nuclear pore organization (GO:0006999)2.44581745
131mitochondrial DNA metabolic process (GO:0032042)2.44152878
132RNA-dependent DNA replication (GO:0006278)2.44127357
133regulation of timing of cell differentiation (GO:0048505)2.43794854
134DNA integration (GO:0015074)2.41990655
135negative regulation of telomere maintenance (GO:0032205)2.41146904
136natural killer cell activation involved in immune response (GO:0002323)2.41078284
137cell differentiation involved in metanephros development (GO:0072202)2.41052384
138regulation of double-strand break repair via homologous recombination (GO:0010569)2.40082998
139protein heterotetramerization (GO:0051290)2.39460824
140response to muramyl dipeptide (GO:0032495)2.38467135
141proteasome assembly (GO:0043248)2.37875179
142mesonephros development (GO:0001823)2.37131493
143telomere maintenance via telomerase (GO:0007004)2.36066252
144regulation of antigen processing and presentation (GO:0002577)2.35448638
145cellular response to gamma radiation (GO:0071480)2.33960519
146extracellular regulation of signal transduction (GO:1900115)2.32412000
147extracellular negative regulation of signal transduction (GO:1900116)2.32412000
148negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.31427992
149regulation of interleukin-8 secretion (GO:2000482)2.31227398
150negative regulation of stem cell proliferation (GO:2000647)2.30958155
151adenosine metabolic process (GO:0046085)2.30649546
152detection of external biotic stimulus (GO:0098581)2.30171503
153positive regulation of keratinocyte differentiation (GO:0045618)2.29564075
154dendritic cell migration (GO:0036336)2.29176125
155cytochrome complex assembly (GO:0017004)2.28838109
156dentate gyrus development (GO:0021542)2.28062728
157sequestering of actin monomers (GO:0042989)2.27754418
158interferon-gamma production (GO:0032609)2.26916424
159detection of molecule of bacterial origin (GO:0032490)2.25221956
160preassembly of GPI anchor in ER membrane (GO:0016254)2.24895869
161lipoxygenase pathway (GO:0019372)2.24463657
162G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.23819457
163glycosphingolipid catabolic process (GO:0046479)2.23309600
164presynaptic membrane organization (GO:0097090)2.23165746
165mesenchymal cell differentiation (GO:0048762)2.20969337
166positive regulation of male gonad development (GO:2000020)2.19649214
167ceramide catabolic process (GO:0046514)2.18916299
168pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.18849009
169transcription from RNA polymerase I promoter (GO:0006360)2.16678036
170synapsis (GO:0007129)2.16360346
171facial nerve structural organization (GO:0021612)2.15069872
172positive regulation of epidermal cell differentiation (GO:0045606)2.15055915
173regulation of development, heterochronic (GO:0040034)2.14951600
174positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.14851477
175pyrimidine dimer repair (GO:0006290)2.14384180
176negative regulation of myeloid cell apoptotic process (GO:0033033)2.13902055
177termination of RNA polymerase I transcription (GO:0006363)2.13772290
178positive regulation of interleukin-1 beta secretion (GO:0050718)2.12625223
179purinergic nucleotide receptor signaling pathway (GO:0035590)2.11298636
180positive regulation of interleukin-17 production (GO:0032740)2.11227974
181embryonic digestive tract morphogenesis (GO:0048557)2.11092578
182detection of biotic stimulus (GO:0009595)2.10511179
183RNA capping (GO:0036260)2.10365384
1847-methylguanosine RNA capping (GO:0009452)2.10365384
185regulation of water loss via skin (GO:0033561)2.09836838
186detection of light stimulus involved in sensory perception (GO:0050962)2.08893599
187detection of light stimulus involved in visual perception (GO:0050908)2.08893599
188positive regulation of T cell migration (GO:2000406)2.07955614
189inner ear receptor stereocilium organization (GO:0060122)2.07697444
190auditory receptor cell stereocilium organization (GO:0060088)2.06839804
191detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.06045190
192inner ear receptor cell differentiation (GO:0060113)2.05599825
193regulation of keratinocyte proliferation (GO:0010837)2.05291652
194regulation of G0 to G1 transition (GO:0070316)2.05157761
195startle response (GO:0001964)2.04444942
196nucleoside diphosphate catabolic process (GO:0009134)2.04111927
197regulation of DNA endoreduplication (GO:0032875)2.04046317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.12794858
2PCGF2_27294783_Chip-Seq_ESCs_Mouse3.05054464
3GBX2_23144817_ChIP-Seq_PC3_Human3.04657677
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90311737
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.84719886
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.80748648
7TP63_19390658_ChIP-ChIP_HaCaT_Human2.74573767
8* MYC_22102868_ChIP-Seq_BL_Human2.73262808
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62525997
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60927006
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.57275076
12VDR_21846776_ChIP-Seq_THP-1_Human2.55403004
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.52192575
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.51956148
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49175451
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.43524912
17PCGF2_27294783_Chip-Seq_NPCs_Mouse2.40779729
18NFE2_27457419_Chip-Seq_LIVER_Mouse2.33987575
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27769311
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27296041
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.27168575
22* LXR_22292898_ChIP-Seq_THP-1_Human2.24783830
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24054662
24RACK7_27058665_Chip-Seq_MCF-7_Human2.23714025
25ZNF263_19887448_ChIP-Seq_K562_Human2.19603415
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.14261861
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.07681847
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05896861
29XRN2_22483619_ChIP-Seq_HELA_Human2.05712797
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.05317256
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95223958
32ESR1_15608294_ChIP-ChIP_MCF-7_Human1.91810190
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91633417
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90492106
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.90220932
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.88606851
37EZH2_27294783_Chip-Seq_NPCs_Mouse1.87971053
38SUZ12_18555785_Chip-Seq_ESCs_Mouse1.85112910
39STAT3_18555785_Chip-Seq_ESCs_Mouse1.84454609
40E2F1_18555785_Chip-Seq_ESCs_Mouse1.81537092
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.80888920
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78036728
43* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77496136
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.77188362
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76474930
46RNF2_27304074_Chip-Seq_NSC_Mouse1.76372049
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.75700980
48P53_22387025_ChIP-Seq_ESCs_Mouse1.75431255
49EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.75260499
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.74830648
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.74097352
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.73276068
53NMYC_18555785_Chip-Seq_ESCs_Mouse1.73033315
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70547049
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67240215
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67188074
57RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65292265
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64105924
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63421696
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61430327
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.61061260
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.60766872
63* P68_20966046_ChIP-Seq_HELA_Human1.60567224
64IRF1_19129219_ChIP-ChIP_H3396_Human1.60497928
65P300_18555785_Chip-Seq_ESCs_Mouse1.59687368
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.59416598
67IGF1R_20145208_ChIP-Seq_DFB_Human1.59409355
68SOX2_18555785_Chip-Seq_ESCs_Mouse1.58431300
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.57780027
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57583710
71CMYC_18555785_Chip-Seq_ESCs_Mouse1.57474504
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56498527
73OCT4_18555785_Chip-Seq_ESCs_Mouse1.56137279
74TAF15_26573619_Chip-Seq_HEK293_Human1.56039636
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54138485
76PU1_27457419_Chip-Seq_LIVER_Mouse1.52381411
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52054376
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.51692984
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50823673
80* TET1_21451524_ChIP-Seq_MESCs_Mouse1.50799700
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50611531
82* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50391833
83P300_19829295_ChIP-Seq_ESCs_Human1.49413560
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47787887
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.47430005
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46988611
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45449421
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.45071341
89* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44891190
90TCF7_22412390_ChIP-Seq_EML_Mouse1.44839391
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.43742282
92* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43171963
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43011837
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42326705
95ESRRB_18555785_Chip-Seq_ESCs_Mouse1.41208472
96KDM2B_26808549_Chip-Seq_DND41_Human1.40960644
97DCP1A_22483619_ChIP-Seq_HELA_Human1.39311409
98CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.38357339
99EWS_26573619_Chip-Seq_HEK293_Human1.37856937
100KDM5A_27292631_Chip-Seq_BREAST_Human1.37575453
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37253752
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36912876
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36670336
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.35910572
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.35067617
106IRF8_21731497_ChIP-ChIP_J774_Mouse1.34815033
107VDR_22108803_ChIP-Seq_LS180_Human1.34569398
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34013241
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32971606
110HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30825349
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.30445361
112RUNX1_27514584_Chip-Seq_MCF-7_Human1.29886532
113ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29415018
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28246432
115E2F7_22180533_ChIP-Seq_HELA_Human1.28203541
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27848077
117PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27704497
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.27025732
119CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26903854
120* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26619789
121CRX_20693478_ChIP-Seq_RETINA_Mouse1.25805394
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25715919
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25509309
124MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25448533
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.25299848
126ATF3_27146783_Chip-Seq_COLON_Human1.24427705
127GABP_19822575_ChIP-Seq_HepG2_Human1.24106738
128* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24033702
129* SMC4_20622854_ChIP-Seq_HELA_Human1.23428900
130KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.23407191
131JARID2_20064375_ChIP-Seq_MESCs_Mouse1.23363833
132ER_23166858_ChIP-Seq_MCF-7_Human1.22925080
133KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20876753
134CREB1_26743006_Chip-Seq_LNCaP_Human1.20871414
135* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20748404
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20656365
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.20021026
138* SA1_27219007_Chip-Seq_ERYTHROID_Human1.19781960
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19403735
140TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18936725
141ESR1_21235772_ChIP-Seq_MCF-7_Human1.17627862
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.17019866
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16842933
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16511286
145TP53_18474530_ChIP-ChIP_U2OS_Human1.16409777
146SALL1_21062744_ChIP-ChIP_HESCs_Human1.15136541
147FUS_26573619_Chip-Seq_HEK293_Human1.15098464
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14714136
149* KDM2B_26808549_Chip-Seq_K562_Human1.14046484
150* NCOR1_26117541_ChIP-Seq_K562_Human1.13805901
151E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13001310
152SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11875252
153OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11629067
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11436052
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11362684
156* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10679955
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.09880245
158KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.09880245
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.09880245
160* FOXP1_21924763_ChIP-Seq_HESCs_Human1.09589049
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09552616
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09552616
163EGR1_19374776_ChIP-ChIP_THP-1_Human1.09184841
164ETS1_20019798_ChIP-Seq_JURKAT_Human1.08923126
165SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08469323
166AR_21909140_ChIP-Seq_LNCAP_Human1.08115639
167MAF_26560356_Chip-Seq_TH2_Human1.07948342
168* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06970060
169CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05659546
170DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05528052
171LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05371729
172JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05334332
173TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05233685
174CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05180355
175SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05159244
176HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04950399
177KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04638281
178RARA_24833708_ChIP-Seq_LIVER_Mouse1.04374154
179* BCOR_27268052_Chip-Seq_Bcells_Human1.04327773
180MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03615655
181KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03598872
182NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02884048
183BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02828165
184IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02326610
185MAF_26560356_Chip-Seq_TH1_Human1.02308937
186PKCTHETA_26484144_Chip-Seq_BREAST_Human1.02060495
187KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01195955
188* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01149324
189CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98690222
190RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97519986
191* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95472414
192* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95472414
193SMAD4_21799915_ChIP-Seq_A2780_Human0.95015644
194CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94423143
195SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.93678676
196PIAS1_25552417_ChIP-Seq_VCAP_Human0.91437752
197* EZH2_27294783_Chip-Seq_ESCs_Mouse0.91346912
198STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90179465

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.16980078
2MP0010234_abnormal_vibrissa_follicle4.15448464
3MP0003705_abnormal_hypodermis_morpholog3.97027723
4MP0001188_hyperpigmentation3.89342418
5MP0003941_abnormal_skin_development3.54210771
6MP0003136_yellow_coat_color3.17321801
7MP0006292_abnormal_olfactory_placode3.04038961
8MP0005076_abnormal_cell_differentiation3.03100508
9MP0002254_reproductive_system_inflammat2.90769552
10MP0002796_impaired_skin_barrier2.84830444
11MP0003693_abnormal_embryo_hatching2.65548221
12MP0005171_absent_coat_pigmentation2.60653605
13MP0004381_abnormal_hair_follicle2.59437136
14MP0004957_abnormal_blastocyst_morpholog2.54099494
15MP0005501_abnormal_skin_physiology2.53013306
16MP0000537_abnormal_urethra_morphology2.43272523
17MP0004264_abnormal_extraembryonic_tissu2.37489965
18MP0005409_darkened_coat_color2.23837330
19MP0003453_abnormal_keratinocyte_physiol2.20382808
20MP0003077_abnormal_cell_cycle2.19133269
21MP0004233_abnormal_muscle_weight2.15554789
22MP0004185_abnormal_adipocyte_glucose2.10761519
23MP0000015_abnormal_ear_pigmentation2.06697940
24MP0002132_abnormal_respiratory_system2.04878975
25MP0002877_abnormal_melanocyte_morpholog2.01719048
26MP0001986_abnormal_taste_sensitivity1.94348509
27MP0008057_abnormal_DNA_replication1.93715135
28MP0010030_abnormal_orbit_morphology1.91087826
29MP0005058_abnormal_lysosome_morphology1.88888202
30MP0004858_abnormal_nervous_system1.87502592
31MP0002638_abnormal_pupillary_reflex1.84966841
32MP0001849_ear_inflammation1.78896326
33MP0005075_abnormal_melanosome_morpholog1.75485117
34MP0009697_abnormal_copulation1.74509297
35MP0004782_abnormal_surfactant_physiolog1.73253751
36MP0000377_abnormal_hair_follicle1.70006138
37MP0002277_abnormal_respiratory_mucosa1.69556582
38MP0003787_abnormal_imprinting1.69073559
39MP0000678_abnormal_parathyroid_gland1.67524950
40MP0003123_paternal_imprinting1.67285096
41MP0003786_premature_aging1.64366315
42MP0000372_irregular_coat_pigmentation1.61800789
43MP0005646_abnormal_pituitary_gland1.61714079
44MP0000049_abnormal_middle_ear1.60959152
45MP0008058_abnormal_DNA_repair1.59950986
46MP0001730_embryonic_growth_arrest1.59049824
47MP0010386_abnormal_urinary_bladder1.57788385
48MP0008007_abnormal_cellular_replicative1.56389128
49MP0008932_abnormal_embryonic_tissue1.55201909
50MP0009672_abnormal_birth_weight1.55140360
51MP0002148_abnormal_hypersensitivity_rea1.54462782
52MP0000383_abnormal_hair_follicle1.48510027
53MP0001346_abnormal_lacrimal_gland1.48251483
54MP0002009_preneoplasia1.47355541
55MP0002163_abnormal_gland_morphology1.46696051
56MP0005645_abnormal_hypothalamus_physiol1.46397376
57MP0008789_abnormal_olfactory_epithelium1.45702556
58MP0005423_abnormal_somatic_nervous1.44485901
59MP0001348_abnormal_lacrimal_gland1.43920990
60MP0000350_abnormal_cell_proliferation1.42296006
61MP0005174_abnormal_tail_pigmentation1.39471964
62MP0000762_abnormal_tongue_morphology1.38081439
63MP0005380_embryogenesis_phenotype1.35651346
64MP0001672_abnormal_embryogenesis/_devel1.35651346
65MP0002876_abnormal_thyroid_physiology1.32888207
66MP0002080_prenatal_lethality1.30061680
67MP0002095_abnormal_skin_pigmentation1.29900890
68MP0002089_abnormal_postnatal_growth/wei1.29817565
69MP0003315_abnormal_perineum_morphology1.29184760
70MP0005503_abnormal_tendon_morphology1.28941243
71MP0002249_abnormal_larynx_morphology1.28581185
72MP0009278_abnormal_bone_marrow1.27488500
73MP0005451_abnormal_body_composition1.27000797
74MP0003566_abnormal_cell_adhesion1.26921884
75MP0002751_abnormal_autonomic_nervous1.25630193
76MP0010307_abnormal_tumor_latency1.25384389
77MP0000647_abnormal_sebaceous_gland1.24231296
78MP0001542_abnormal_bone_strength1.23350044
79MP0008260_abnormal_autophagy1.22762503
80MP0000462_abnormal_digestive_system1.22482344
81MP0000750_abnormal_muscle_regeneration1.21823471
82MP0008995_early_reproductive_senescence1.21527766
83MP0003984_embryonic_growth_retardation1.20834872
84MP0001835_abnormal_antigen_presentation1.19995360
85MP0002102_abnormal_ear_morphology1.17492839
86MP0010678_abnormal_skin_adnexa1.17345549
87MP0005671_abnormal_response_to1.16237274
88MP0002088_abnormal_embryonic_growth/wei1.15509635
89MP0003878_abnormal_ear_physiology1.15365828
90MP0005377_hearing/vestibular/ear_phenot1.15365828
91MP0000467_abnormal_esophagus_morphology1.15124656
92MP0010771_integument_phenotype1.14809100
93MP0009931_abnormal_skin_appearance1.14629282
94MP0004134_abnormal_chest_morphology1.12322367
95MP0000858_altered_metastatic_potential1.12238152
96MP0001697_abnormal_embryo_size1.12185218
97MP0005367_renal/urinary_system_phenotyp1.11134606
98MP0000516_abnormal_urinary_system1.11134606
99MP0002060_abnormal_skin_morphology1.10495296
100MP0002085_abnormal_embryonic_tissue1.09502734
101MP0002098_abnormal_vibrissa_morphology1.08564695
102MP0009785_altered_susceptibility_to1.07798817
103MP0005257_abnormal_intraocular_pressure1.07768320
104MP0002938_white_spotting1.06898870
105MP0009250_abnormal_appendicular_skeleto1.06756416
106MP0009780_abnormal_chondrocyte_physiolo1.06450421
107MP0004197_abnormal_fetal_growth/weight/1.04771464
108MP0005394_taste/olfaction_phenotype1.04658262
109MP0005499_abnormal_olfactory_system1.04658262
110MP0002086_abnormal_extraembryonic_tissu1.03449572
111MP0003111_abnormal_nucleus_morphology1.03393335
112MP0001186_pigmentation_phenotype1.02579822
113MP0009840_abnormal_foam_cell1.02452805
114MP0000579_abnormal_nail_morphology1.00673988
115MP0000313_abnormal_cell_death0.99043938
116MP0002160_abnormal_reproductive_system0.99021560
117MP0005508_abnormal_skeleton_morphology0.98860585
118MP0002111_abnormal_tail_morphology0.98220451
119MP0005666_abnormal_adipose_tissue0.96807127
120MP0000003_abnormal_adipose_tissue0.96238159
121MP0000733_abnormal_muscle_development0.96077644
122MP0000026_abnormal_inner_ear0.95982563
123MP0003763_abnormal_thymus_physiology0.95469145
124MP0001984_abnormal_olfaction0.94734517
125MP0003880_abnormal_central_pattern0.94423556
126MP0003718_maternal_effect0.94149443
127MP0000747_muscle_weakness0.93898958
128MP0000681_abnormal_thyroid_gland0.93666306
129MP0000613_abnormal_salivary_gland0.93415111
130MP0002177_abnormal_outer_ear0.93206047
131MP0002735_abnormal_chemical_nociception0.92092103
132MP0003755_abnormal_palate_morphology0.90777956
133MP0010094_abnormal_chromosome_stability0.90113161
134MP0000358_abnormal_cell_content/0.89716479
135MP0002697_abnormal_eye_size0.89056391
136MP0002084_abnormal_developmental_patter0.88822457
137MP0005379_endocrine/exocrine_gland_phen0.88662958
138MP0001119_abnormal_female_reproductive0.88188086
139MP0001881_abnormal_mammary_gland0.86180905
140MP0005387_immune_system_phenotype0.85319182
141MP0001790_abnormal_immune_system0.85319182
142MP0000627_abnormal_mammary_gland0.85286555
143MP0005389_reproductive_system_phenotype0.84783236
144MP0001727_abnormal_embryo_implantation0.84713862
145MP0003385_abnormal_body_wall0.83530938
146MP0000427_abnormal_hair_cycle0.82871031
147MP0000751_myopathy0.82749148
148MP0002075_abnormal_coat/hair_pigmentati0.80797299
149MP0003942_abnormal_urinary_system0.80216589
150MP0003938_abnormal_ear_development0.80179197
151MP0003724_increased_susceptibility_to0.79818423
152MP0002019_abnormal_tumor_incidence0.79036740
153MP0010352_gastrointestinal_tract_polyps0.78202668
154MP0000490_abnormal_crypts_of0.77849857
155MP0001502_abnormal_circadian_rhythm0.77682904
156MP0005390_skeleton_phenotype0.77319527
157MP0005621_abnormal_cell_physiology0.76132823
158MP0002233_abnormal_nose_morphology0.76074040
159MP0001177_atelectasis0.76066048
160MP0005248_abnormal_Harderian_gland0.75962040
161MP0009333_abnormal_splenocyte_physiolog0.75155697
162MP0002419_abnormal_innate_immunity0.74992375
163MP0002396_abnormal_hematopoietic_system0.74991547
164MP0003806_abnormal_nucleotide_metabolis0.73879624
165MP0005375_adipose_tissue_phenotype0.73701145
166MP0008877_abnormal_DNA_methylation0.72838960
167MP0001216_abnormal_epidermal_layer0.72372824
168MP0004947_skin_inflammation0.72211387
169MP0004808_abnormal_hematopoietic_stem0.71563922
170MP0005310_abnormal_salivary_gland0.71503003
171MP0003115_abnormal_respiratory_system0.71286477
172MP0005384_cellular_phenotype0.71114266
173MP0001873_stomach_inflammation0.70746110
174MP0001286_abnormal_eye_development0.70653237

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.94673281
2Hyperacusis (HP:0010780)4.61583049
3Chromsome breakage (HP:0040012)4.35859204
4Asymmetry of the thorax (HP:0001555)4.17660561
5Duplicated collecting system (HP:0000081)3.63181964
6Abnormality of the renal collecting system (HP:0004742)3.57086123
7Testicular atrophy (HP:0000029)3.34148051
8Thin bony cortex (HP:0002753)3.23296943
9Ulnar bowing (HP:0003031)3.22853573
10Septate vagina (HP:0001153)3.20684325
11Elfin facies (HP:0004428)3.02103487
12Abnormality of incisor morphology (HP:0011063)3.00431231
13Abnormality of DNA repair (HP:0003254)2.94854221
14Insomnia (HP:0100785)2.93454176
15Hypoplasia of the fovea (HP:0007750)2.92819921
16Aplasia/Hypoplasia of the fovea (HP:0008060)2.92819921
17Poikiloderma (HP:0001029)2.91459954
18Progressive muscle weakness (HP:0003323)2.87076396
19Overriding aorta (HP:0002623)2.78378235
20Progressive external ophthalmoplegia (HP:0000590)2.69971142
21White forelock (HP:0002211)2.63459692
22Conical tooth (HP:0000698)2.60960516
23Optic neuritis (HP:0100653)2.60864375
24Retrobulbar optic neuritis (HP:0100654)2.60864375
25Patchy hypopigmentation of hair (HP:0011365)2.60528114
26J-shaped sella turcica (HP:0002680)2.59822752
27Selective tooth agenesis (HP:0001592)2.59511877
28Prostate neoplasm (HP:0100787)2.59374385
29Aplasia cutis congenita (HP:0001057)2.55426768
30Duplication of thumb phalanx (HP:0009942)2.53113697
31Squamous cell carcinoma (HP:0002860)2.53049026
32Trismus (HP:0000211)2.53002811
33Septo-optic dysplasia (HP:0100842)2.51844394
34Stomach cancer (HP:0012126)2.51438142
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50453342
36Turricephaly (HP:0000262)2.42046595
37Pterygium (HP:0001059)2.41872740
38Abnormality of the nasal septum (HP:0000419)2.41022638
39Ectopic kidney (HP:0000086)2.40501065
40Abnormality of the preputium (HP:0100587)2.38752036
41Cheilitis (HP:0100825)2.36624417
42Myopathic facies (HP:0002058)2.36331044
43Increased nuchal translucency (HP:0010880)2.32920222
44Flat acetabular roof (HP:0003180)2.31866171
45Microvesicular hepatic steatosis (HP:0001414)2.31643824
46Renal duplication (HP:0000075)2.30777098
47Long palpebral fissure (HP:0000637)2.29805319
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.29026303
49Abnormality of the fovea (HP:0000493)2.27799064
50Popliteal pterygium (HP:0009756)2.26445624
51Type I transferrin isoform profile (HP:0003642)2.26102068
52Milia (HP:0001056)2.25824336
53Germ cell neoplasia (HP:0100728)2.24752388
54Meckel diverticulum (HP:0002245)2.24447795
55Abnormal hair whorl (HP:0010721)2.22869570
56Proximal placement of thumb (HP:0009623)2.22270413
57Lip pit (HP:0100267)2.19861420
58Abnormality of the ileum (HP:0001549)2.19406316
59Deviation of the thumb (HP:0009603)2.19378065
60Ragged-red muscle fibers (HP:0003200)2.17106933
61Achilles tendon contracture (HP:0001771)2.16379538
62Breast hypoplasia (HP:0003187)2.15490363
63Clubbing of toes (HP:0100760)2.15012151
64Broad face (HP:0000283)2.14941846
65Pili torti (HP:0003777)2.14238872
66Broad distal phalanx of finger (HP:0009836)2.13238966
67Febrile seizures (HP:0002373)2.13238136
68Osteomalacia (HP:0002749)2.12384187
69Sparse lateral eyebrow (HP:0005338)2.12337962
70Nasolacrimal duct obstruction (HP:0000579)2.11846515
71Delayed epiphyseal ossification (HP:0002663)2.11148339
72Microglossia (HP:0000171)2.10450084
73Renal cortical cysts (HP:0000803)2.09937560
74Multiple enchondromatosis (HP:0005701)2.06669171
75Adrenal hypoplasia (HP:0000835)2.06609970
76True hermaphroditism (HP:0010459)2.06264333
77High anterior hairline (HP:0009890)2.05422331
78Spina bifida occulta (HP:0003298)2.05088978
79Abnormality of the nasolacrimal system (HP:0000614)2.04846861
80Abnormality of molar morphology (HP:0011070)2.04524926
81Abnormality of molar (HP:0011077)2.04524926
82Rib fusion (HP:0000902)2.04480174
83Abnormality of chromosome stability (HP:0003220)2.04459657
84Abnormality of the lacrimal duct (HP:0011481)2.04396238
85Congenital sensorineural hearing impairment (HP:0008527)2.04205847
86Micronodular cirrhosis (HP:0001413)2.03009236
87Submucous cleft hard palate (HP:0000176)2.02430010
883-Methylglutaconic aciduria (HP:0003535)2.01978777
89Optic nerve hypoplasia (HP:0000609)2.01913040
90Absent eyebrow (HP:0002223)2.01741614
91Thin ribs (HP:0000883)2.01429241
92Abnormality of nail color (HP:0100643)2.00612584
93Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99501556
94Abnormality of the umbilical cord (HP:0010881)1.97758314
95Xerostomia (HP:0000217)1.97555963
96Distal lower limb muscle weakness (HP:0009053)1.96168925
97Recurrent abscess formation (HP:0002722)1.95828878
98Vaginal fistula (HP:0004320)1.95517386
99Ureteral duplication (HP:0000073)1.94538138
100Median cleft lip (HP:0000161)1.94236174
101Abnormal gallbladder physiology (HP:0012438)1.93433186
102Cholecystitis (HP:0001082)1.93433186
103Abnormality of the thoracic spine (HP:0100711)1.93204851
104Advanced eruption of teeth (HP:0006288)1.92808202
105Hypergonadotropic hypogonadism (HP:0000815)1.92776227
106Birth length less than 3rd percentile (HP:0003561)1.92671432
107Abnormality of the parietal bone (HP:0002696)1.92371022
108Patellar dislocation (HP:0002999)1.92171696
109Increased IgM level (HP:0003496)1.91689919
110Pulmonary artery stenosis (HP:0004415)1.91567636
111Pointed chin (HP:0000307)1.90778999
112Abnormality of the dental root (HP:0006486)1.90296838
113Taurodontia (HP:0000679)1.90296838
114Abnormality of permanent molar morphology (HP:0011071)1.90296838
115Abnormality of the distal phalanges of the toes (HP:0010182)1.89853408
116Dry hair (HP:0011359)1.89715208
117Orchitis (HP:0100796)1.89687321
118Hypoparathyroidism (HP:0000829)1.89281278
119Patellar aplasia (HP:0006443)1.87770449
120Onycholysis (HP:0001806)1.87227058
121Short middle phalanx of the 5th finger (HP:0004220)1.86575141
122Abnormalities of placenta or umbilical cord (HP:0001194)1.86413331
123Renovascular hypertension (HP:0100817)1.86386168
124Stridor (HP:0010307)1.86302843
125Preaxial hand polydactyly (HP:0001177)1.86221819
126Abnormality of the incisor (HP:0000676)1.86162888
127Congenital stationary night blindness (HP:0007642)1.84616107
128Intestinal fistula (HP:0100819)1.84394000
129Neoplasm of the adrenal cortex (HP:0100641)1.83781938
13011 pairs of ribs (HP:0000878)1.83680672
131Flat cornea (HP:0007720)1.83042397
132Abnormality of the columella (HP:0009929)1.82874373
133Short thumb (HP:0009778)1.81433569
134Reticulocytosis (HP:0001923)1.78714842
135Aplasia/Hypoplasia of the patella (HP:0006498)1.78415270
136Abnormality of the Achilles tendon (HP:0005109)1.78247628
137Atresia of the external auditory canal (HP:0000413)1.78228125
138Distal upper limb amyotrophy (HP:0007149)1.78205817
139Upper limb amyotrophy (HP:0009129)1.78205817
140Facial hemangioma (HP:0000329)1.77923082
141Alveolar cell carcinoma (HP:0006519)1.77725877
142Ridged nail (HP:0001807)1.77240934
143Abnormality of cells of the erythroid lineage (HP:0012130)1.77224326
144Hypothermia (HP:0002045)1.77127635
145Dysmetric saccades (HP:0000641)1.76958688
146Diaphragmatic weakness (HP:0009113)1.76736596
147Myositis (HP:0100614)1.76035361
148Flattened epiphyses (HP:0003071)1.75746153
149Abnormal hair laboratory examination (HP:0003328)1.75664686
150Abnormality of reticulocytes (HP:0004312)1.74200520
151Abdominal distention (HP:0003270)1.73909539
152Morphological abnormality of the middle ear (HP:0008609)1.73841835
153Leiomyosarcoma (HP:0100243)1.72742133
154Uterine leiomyosarcoma (HP:0002891)1.72742133
155Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72184454
156Ectropion (HP:0000656)1.71674064
157Abnormality of the salivary glands (HP:0010286)1.71464905
158Amelogenesis imperfecta (HP:0000705)1.71166192
159Choanal stenosis (HP:0000452)1.71162474
160Abnormal trabecular bone morphology (HP:0100671)1.69329599
161Atrophic scars (HP:0001075)1.67323445
162Abnormality of the dental pulp (HP:0006479)1.67127540
163Abnormality of the phalanges of the hallux (HP:0010057)1.67092536
164Abnormality of small intestinal villus morphology (HP:0011472)1.66435831
165Villous atrophy (HP:0011473)1.66435831
166Abnormal number of erythroid precursors (HP:0012131)1.65163970
167Deformed sella turcica (HP:0002681)1.65143495
168Reduced antithrombin III activity (HP:0001976)1.65079369
169Supernumerary bones of the axial skeleton (HP:0009144)1.64703565
170Reticulocytopenia (HP:0001896)1.64670284
171Prolonged neonatal jaundice (HP:0006579)1.64189812
172Glomerulopathy (HP:0100820)1.63971170
173Sparse eyelashes (HP:0000653)1.63458863
174Anhidrosis (HP:0000970)1.63187778
175Spinal cord compression (HP:0002176)1.62927240
176Ankyloglossia (HP:0010296)1.62280273
177Hyperthyroidism (HP:0000836)1.62094200
178Rough bone trabeculation (HP:0100670)1.61635421
179Upper limb muscle weakness (HP:0003484)1.61313062
180Abnormality of placental membranes (HP:0011409)1.60637970
181Amniotic constriction ring (HP:0009775)1.60637970
182Premature skin wrinkling (HP:0100678)1.60514376
183Pancreatic fibrosis (HP:0100732)1.59513418
184Termporal pattern (HP:0011008)1.58822017
185Insidious onset (HP:0003587)1.58822017
186Chronic obstructive pulmonary disease (HP:0006510)1.58616204
187Obstructive lung disease (HP:0006536)1.58616204
188Rectal fistula (HP:0100590)1.57323670
189Aplasia involving bones of the extremities (HP:0009825)1.56948168
190Aplasia involving bones of the upper limbs (HP:0009823)1.56948168
191Aplasia of the phalanges of the hand (HP:0009802)1.56948168
192Fragile nails (HP:0001808)1.56032164
193Absent radius (HP:0003974)1.55971585
194Absent thumb (HP:0009777)1.54903684
195Facial cleft (HP:0002006)1.54112240
196Abnormal sex determination (HP:0012244)1.53718733
197Sex reversal (HP:0012245)1.53718733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.94847276
2SMG14.65704759
3ZAK3.60466898
4EEF2K3.40314191
5NME23.01992476
6MAP3K142.89991596
7PKN22.88757004
8IRAK32.83585963
9SIK12.81791948
10CASK2.81130197
11MAP3K102.66233458
12MKNK22.64144346
13IRAK42.45007799
14TXK2.41446181
15AKT32.39445415
16RPS6KB22.38440567
17STK38L2.21211139
18ICK2.20748889
19BMPR22.18531225
20PLK42.16126778
21CDK122.15106265
22STK162.07235913
23VRK22.03095387
24ERBB31.89541533
25MST1R1.88398390
26MKNK11.82248788
27MAPKAPK31.80619087
28FGFR41.78440647
29EIF2AK21.78123665
30MAP2K71.77743952
31SRPK11.72657938
32TNIK1.69698770
33TESK21.62350408
34YES11.59839049
35IKBKE1.59429329
36CDK81.59412534
37NEK61.57150353
38SIK31.53078120
39BMPR1B1.51742839
40ADRBK21.50146964
41CDK31.42823723
42CLK11.40863726
43EPHA21.40815017
44PAK41.39294355
45STK241.37359112
46LATS21.37249780
47SCYL21.35228577
48IKBKB1.34638207
49PRPF4B1.33718557
50SGK21.31500407
51ERN11.29454623
52NUAK11.24910304
53VRK11.22967903
54NLK1.20500640
55TAOK21.15312611
56MTOR1.13466200
57BUB11.12698933
58GRK11.11899681
59MUSK1.07215915
60ILK1.04244857
61PTK61.03887273
62PIM21.03240677
63TBK11.02510871
64EPHA31.01443540
65TAF10.99483439
66CDK40.99262988
67CHUK0.99098898
68EPHB20.98509143
69TTK0.96427898
70IRAK10.95426075
71CDC70.93498842
72RIPK10.92948479
73MAP2K20.92682233
74AURKA0.87000096
75PINK10.85035842
76MST40.84805159
77SGK4940.83161631
78SGK2230.83161631
79MAP3K30.83158049
80MAPK130.83102820
81NEK10.81641594
82TESK10.81592229
83PBK0.81370185
84IRAK20.80686780
85PIM10.80564581
86INSRR0.78191189
87ATR0.76698554
88TEC0.75632948
89LRRK20.74708546
90EIF2AK10.74308703
91BRAF0.74028388
92MET0.72802703
93PRKCI0.72415205
94TRPM70.71430318
95TTN0.71155144
96PDGFRA0.70945678
97TNK20.70682279
98TSSK60.70147408
99GRK70.70037167
100MAP3K120.69795703
101PLK30.68552301
102PRKD30.68442682
103MAPK70.67960527
104JAK30.66714933
105MAP3K80.62717485
106PRKCE0.61127564
107BMX0.60525586
108AKT20.58042729
109CHEK10.57873178
110RPS6KA20.57833671
111RIPK40.57711974
112EIF2AK30.57304744
113PKN10.56929555
114PLK20.55071276
115DAPK10.54723691
116DYRK1A0.54365951
117MAPK110.52912704
118BRSK10.52442562
119TYRO30.51601648
120SGK30.50918112
121ARAF0.50795888
122PDPK10.50534290
123DYRK20.49973979
124RPS6KA50.49535430
125PTK20.49068875
126PIK3CG0.48716289
127NME10.44711911
128CDK60.44105958
129CDK90.43394649
130RPS6KB10.43255822
131RPS6KA60.43249962
132PLK10.42996407
133TLK10.42556285
134CHEK20.42282529
135MARK30.42246807
136LMTK20.42230022
137CDK70.41909786
138BCR0.41891733
139CDK20.41690596
140EPHA40.41454340
141CDK10.40796173
142CDK150.40260338
143NEK20.40244670
144CDK11A0.40064516
145MAP2K10.39997045
146TAOK10.38701146
147MAPKAPK20.38686980
148MYLK0.38085708
149ALK0.37837149
150BRD40.37801803
151ACVR1B0.37649105
152CDK180.37641290
153RPS6KA40.37128747
154DAPK30.37084337
155BTK0.35941464
156MAP3K110.34837102
157RPS6KL10.34622201
158RPS6KC10.34622201
159LYN0.34442751
160CSNK2A10.33796348
161BLK0.33788164
162FGFR30.33334881
163PRKD20.32322359
164GRK60.32169086
165PRKCD0.31955722
166FRK0.30965747
167DMPK0.30891751
168RET0.30880951
169STK40.30708006
170MAPK150.30524029
171AURKB0.29981971

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.96408131
2Sulfur relay system_Homo sapiens_hsa041222.70030737
3RNA polymerase_Homo sapiens_hsa030202.56877063
4Fanconi anemia pathway_Homo sapiens_hsa034602.41532914
5Fructose and mannose metabolism_Homo sapiens_hsa000512.25949586
6Bladder cancer_Homo sapiens_hsa052192.22525766
7Homologous recombination_Homo sapiens_hsa034402.21578617
8Biosynthesis of amino acids_Homo sapiens_hsa012302.19981664
9Central carbon metabolism in cancer_Homo sapiens_hsa052302.11755786
10Pentose phosphate pathway_Homo sapiens_hsa000302.11209924
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.01702955
12Allograft rejection_Homo sapiens_hsa053301.94593248
13Graft-versus-host disease_Homo sapiens_hsa053321.92000515
14Autoimmune thyroid disease_Homo sapiens_hsa053201.82483667
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81435096
16Thyroid cancer_Homo sapiens_hsa052161.78489779
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.78467768
18Basal transcription factors_Homo sapiens_hsa030221.70846634
19Sphingolipid metabolism_Homo sapiens_hsa006001.68116018
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.66959072
21Base excision repair_Homo sapiens_hsa034101.66017160
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65816735
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65372249
24Arachidonic acid metabolism_Homo sapiens_hsa005901.59106103
25Ribosome_Homo sapiens_hsa030101.59063270
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58911896
27Chronic myeloid leukemia_Homo sapiens_hsa052201.58032150
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55957119
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55462869
30Non-small cell lung cancer_Homo sapiens_hsa052231.50184059
31Non-homologous end-joining_Homo sapiens_hsa034501.48825784
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.47062945
33Endometrial cancer_Homo sapiens_hsa052131.45783003
34Acute myeloid leukemia_Homo sapiens_hsa052211.44448942
35Mismatch repair_Homo sapiens_hsa034301.43576221
36Basal cell carcinoma_Homo sapiens_hsa052171.40770401
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40262945
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36056481
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35479818
40Rheumatoid arthritis_Homo sapiens_hsa053231.35353089
41Pyrimidine metabolism_Homo sapiens_hsa002401.35174066
42mRNA surveillance pathway_Homo sapiens_hsa030151.33445098
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32635648
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.32427836
45DNA replication_Homo sapiens_hsa030301.31574470
46VEGF signaling pathway_Homo sapiens_hsa043701.31357121
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30939547
48Nucleotide excision repair_Homo sapiens_hsa034201.24948312
49Carbon metabolism_Homo sapiens_hsa012001.21894394
50Proteasome_Homo sapiens_hsa030501.21687201
51Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19930378
52Measles_Homo sapiens_hsa051621.19595450
53N-Glycan biosynthesis_Homo sapiens_hsa005101.17645564
54Purine metabolism_Homo sapiens_hsa002301.14659693
55Vitamin B6 metabolism_Homo sapiens_hsa007501.13328854
56RNA degradation_Homo sapiens_hsa030181.13311493
57Herpes simplex infection_Homo sapiens_hsa051681.12553394
58Galactose metabolism_Homo sapiens_hsa000521.10730405
59Lysine degradation_Homo sapiens_hsa003101.09539595
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09458050
61Small cell lung cancer_Homo sapiens_hsa052221.08367632
62MicroRNAs in cancer_Homo sapiens_hsa052061.07312765
63Pancreatic cancer_Homo sapiens_hsa052121.06960222
64Type I diabetes mellitus_Homo sapiens_hsa049401.04830082
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03622459
66Phototransduction_Homo sapiens_hsa047441.03307908
67Hematopoietic cell lineage_Homo sapiens_hsa046401.03230959
68Regulation of autophagy_Homo sapiens_hsa041401.01024538
69Hedgehog signaling pathway_Homo sapiens_hsa043401.00340185
70mTOR signaling pathway_Homo sapiens_hsa041500.99536677
71Glioma_Homo sapiens_hsa052140.97226935
72Asthma_Homo sapiens_hsa053100.91594469
73Prostate cancer_Homo sapiens_hsa052150.91551291
74AMPK signaling pathway_Homo sapiens_hsa041520.90548301
75Primary immunodeficiency_Homo sapiens_hsa053400.90047102
76TNF signaling pathway_Homo sapiens_hsa046680.88928351
77Cell cycle_Homo sapiens_hsa041100.88839158
78Insulin signaling pathway_Homo sapiens_hsa049100.87301598
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87220337
80Legionellosis_Homo sapiens_hsa051340.86884674
81Viral carcinogenesis_Homo sapiens_hsa052030.86800911
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86260688
83Nicotine addiction_Homo sapiens_hsa050330.85864862
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85739911
85Influenza A_Homo sapiens_hsa051640.85632582
86Taste transduction_Homo sapiens_hsa047420.85401733
87Folate biosynthesis_Homo sapiens_hsa007900.84574940
88p53 signaling pathway_Homo sapiens_hsa041150.83930902
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81601034
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.80085631
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79900957
92Leishmaniasis_Homo sapiens_hsa051400.79369369
93Vibrio cholerae infection_Homo sapiens_hsa051100.79139267
94B cell receptor signaling pathway_Homo sapiens_hsa046620.78407683
95ErbB signaling pathway_Homo sapiens_hsa040120.78096080
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.78051620
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77378186
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76712682
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76485155
100Inositol phosphate metabolism_Homo sapiens_hsa005620.75793478
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75783072
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75401141
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75191958
104Spliceosome_Homo sapiens_hsa030400.74804180
105Vitamin digestion and absorption_Homo sapiens_hsa049770.73670681
106Epstein-Barr virus infection_Homo sapiens_hsa051690.73066690
107Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.72861676
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72827781
109Ether lipid metabolism_Homo sapiens_hsa005650.71689491
110Malaria_Homo sapiens_hsa051440.68702610
111Colorectal cancer_Homo sapiens_hsa052100.68576281
112Lysosome_Homo sapiens_hsa041420.68553435
113Proteoglycans in cancer_Homo sapiens_hsa052050.68459283
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.67037461
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65975548
116Renal cell carcinoma_Homo sapiens_hsa052110.65641203
117Mineral absorption_Homo sapiens_hsa049780.65371598
118African trypanosomiasis_Homo sapiens_hsa051430.63976446
119Pyruvate metabolism_Homo sapiens_hsa006200.62807999
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61887551
121Other glycan degradation_Homo sapiens_hsa005110.60696646
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59910074
123Serotonergic synapse_Homo sapiens_hsa047260.59313464
124Protein export_Homo sapiens_hsa030600.57955084
125Steroid biosynthesis_Homo sapiens_hsa001000.57288649
126Linoleic acid metabolism_Homo sapiens_hsa005910.56902769
127Apoptosis_Homo sapiens_hsa042100.56572598
128Wnt signaling pathway_Homo sapiens_hsa043100.56540601
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55212086
130Pertussis_Homo sapiens_hsa051330.55029961
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54335170
132Cysteine and methionine metabolism_Homo sapiens_hsa002700.54004127
133Alcoholism_Homo sapiens_hsa050340.53667018
134HTLV-I infection_Homo sapiens_hsa051660.53568202
135Morphine addiction_Homo sapiens_hsa050320.53241450
136alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53084420
137Systemic lupus erythematosus_Homo sapiens_hsa053220.52713784
138Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52507937
139Tight junction_Homo sapiens_hsa045300.51287554
140Hepatitis C_Homo sapiens_hsa051600.51048662
141Tuberculosis_Homo sapiens_hsa051520.50207914
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.50058599
143Prion diseases_Homo sapiens_hsa050200.49669365
144Shigellosis_Homo sapiens_hsa051310.48609359
145HIF-1 signaling pathway_Homo sapiens_hsa040660.48369841
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47613291
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47430960
148Notch signaling pathway_Homo sapiens_hsa043300.47385814
149RNA transport_Homo sapiens_hsa030130.47111946
150Olfactory transduction_Homo sapiens_hsa047400.45521802
151Salmonella infection_Homo sapiens_hsa051320.45328678
152Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44788322
153Pathways in cancer_Homo sapiens_hsa052000.44738620
154Melanoma_Homo sapiens_hsa052180.44610492
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44400034
156Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43853279
157Hepatitis B_Homo sapiens_hsa051610.43118865
158One carbon pool by folate_Homo sapiens_hsa006700.42875554
159Phagosome_Homo sapiens_hsa041450.42640237
160Chemokine signaling pathway_Homo sapiens_hsa040620.41760736
161Circadian rhythm_Homo sapiens_hsa047100.40206298
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39352736
163Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.39092706
164Protein digestion and absorption_Homo sapiens_hsa049740.39079064
165Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36842214
166Hippo signaling pathway_Homo sapiens_hsa043900.36258703
167Steroid hormone biosynthesis_Homo sapiens_hsa001400.36017178

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