KRI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene overlaps with the gene for cysteine endopeptidase AUT-like 4 in a head-to-tail orientation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein deneddylation (GO:0000338)9.69978202
2regulation of histone H3-K27 methylation (GO:0061085)6.16124219
3endothelial tube morphogenesis (GO:0061154)5.61338972
4morphogenesis of an endothelium (GO:0003159)5.61338972
5ribosomal small subunit biogenesis (GO:0042274)4.98176269
6regulation of endothelial cell chemotaxis (GO:2001026)4.82897891
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.76983241
8negative regulation of cell killing (GO:0031342)4.76983241
9nuclear pore organization (GO:0006999)4.45665340
10regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.41559615
11nuclear pore complex assembly (GO:0051292)4.34090037
12positive regulation of gamma-delta T cell activation (GO:0046645)4.32187680
13positive regulation of keratinocyte differentiation (GO:0045618)4.20932319
14oxaloacetate metabolic process (GO:0006107)4.12424306
15negative thymic T cell selection (GO:0045060)3.86441247
16DNA unwinding involved in DNA replication (GO:0006268)3.84503451
17regulation of gamma-delta T cell differentiation (GO:0045586)3.84355645
18regulation of mammary gland epithelial cell proliferation (GO:0033599)3.83616352
19positive regulation of activated T cell proliferation (GO:0042104)3.81966016
20positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.81392887
21positive regulation of natural killer cell mediated immunity (GO:0002717)3.80228916
22negative T cell selection (GO:0043383)3.80224324
23regulation of transcription from RNA polymerase I promoter (GO:0006356)3.69919472
24regulation of activation of Janus kinase activity (GO:0010533)3.69826782
25protein localization to kinetochore (GO:0034501)3.66564432
26regulation of histone deacetylation (GO:0031063)3.66429549
27tRNA modification (GO:0006400)3.65720218
28positive thymic T cell selection (GO:0045059)3.62374095
29regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.58958397
30regulation of natural killer cell mediated immunity (GO:0002715)3.58958397
31translational elongation (GO:0006414)3.56048327
32pore complex assembly (GO:0046931)3.51983314
33viral mRNA export from host cell nucleus (GO:0046784)3.51633602
34regulation of mitochondrial translation (GO:0070129)3.47834517
35DNA duplex unwinding (GO:0032508)3.47736705
36DNA geometric change (GO:0032392)3.45744451
37mitotic nuclear envelope disassembly (GO:0007077)3.45672490
38rRNA transcription (GO:0009303)3.42659013
39negative regulation of histone methylation (GO:0031061)3.41612904
40regulation of gamma-delta T cell activation (GO:0046643)3.41469176
41positive regulation of T cell apoptotic process (GO:0070234)3.33912407
42thymic T cell selection (GO:0045061)3.31774042
43pre-miRNA processing (GO:0031054)3.30578031
44regulation of histone H3-K9 methylation (GO:0051570)3.30033818
45positive regulation of DNA biosynthetic process (GO:2000573)3.29806302
46positive regulation of CREB transcription factor activity (GO:0032793)3.29224796
47antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27966732
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27966732
49negative regulation of viral release from host cell (GO:1902187)3.26091867
50positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23306731
51viral life cycle (GO:0019058)3.21159050
52nuclear envelope disassembly (GO:0051081)3.21064578
53membrane disassembly (GO:0030397)3.21064578
54negative regulation of viral entry into host cell (GO:0046597)3.18872717
55IMP biosynthetic process (GO:0006188)3.15436473
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14444561
57positive regulation of protein import into nucleus, translocation (GO:0033160)3.13108858
58protein localization to chromosome, centromeric region (GO:0071459)3.12207622
59cellular protein complex disassembly (GO:0043624)3.11877775
60positive regulation of protein deacetylation (GO:0090312)3.11809770
61regulation of B cell receptor signaling pathway (GO:0050855)3.10966515
62formation of translation preinitiation complex (GO:0001731)3.10146331
63mitotic sister chromatid cohesion (GO:0007064)3.08380769
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.08272596
65folic acid-containing compound biosynthetic process (GO:0009396)3.07870577
66mitotic sister chromatid segregation (GO:0000070)3.05704639
67translational initiation (GO:0006413)3.01768318
68positive regulation of interleukin-2 production (GO:0032743)3.01515479
69DNA strand elongation involved in DNA replication (GO:0006271)3.01333330
70opsonization (GO:0008228)2.99387187
71negative regulation of erythrocyte differentiation (GO:0045647)2.98981922
72intracellular estrogen receptor signaling pathway (GO:0030520)2.98774385
73dosage compensation (GO:0007549)2.98052063
74protein targeting to ER (GO:0045047)2.97774108
75sister chromatid segregation (GO:0000819)2.96584370
76cotranslational protein targeting to membrane (GO:0006613)2.95752955
77protein complex disassembly (GO:0043241)2.95188035
78megakaryocyte development (GO:0035855)2.94816736
79heterochromatin organization (GO:0070828)2.92397089
80DNA replication initiation (GO:0006270)2.92222741
81negative regulation of RNA splicing (GO:0033119)2.92170622
82leukocyte aggregation (GO:0070486)2.90844285
83mitotic chromosome condensation (GO:0007076)2.90636240
84positive regulation of macrophage cytokine production (GO:0060907)2.90535036
85macrophage chemotaxis (GO:0048246)2.89847109
86antigen processing and presentation of endogenous antigen (GO:0019883)2.89798684
87ribosomal small subunit assembly (GO:0000028)2.87927822
88ventricular trabecula myocardium morphogenesis (GO:0003222)2.86986336
89DNA strand elongation (GO:0022616)2.86745176
90T cell selection (GO:0045058)2.85528512
91regulation of translational fidelity (GO:0006450)2.84922954
92B cell receptor signaling pathway (GO:0050853)2.84665909
93positive regulation of isotype switching (GO:0045830)2.83954928
94IMP metabolic process (GO:0046040)2.83719605
95regulation of chronic inflammatory response (GO:0002676)2.83410630
96establishment of integrated proviral latency (GO:0075713)2.82280925
97positive T cell selection (GO:0043368)2.81504399
98establishment of protein localization to endoplasmic reticulum (GO:0072599)2.79802002
99regulation of T cell receptor signaling pathway (GO:0050856)2.79401832
100regulation of spindle organization (GO:0090224)2.77171856
101DNA conformation change (GO:0071103)2.77084652
102regulation of translational termination (GO:0006449)2.75687966
103alternative mRNA splicing, via spliceosome (GO:0000380)2.74466603
104macromolecular complex disassembly (GO:0032984)2.73969215
105magnesium ion transport (GO:0015693)2.72947759
106heart trabecula morphogenesis (GO:0061384)2.72935190
107maturation of SSU-rRNA (GO:0030490)2.71535050
108ribosome biogenesis (GO:0042254)2.71269089
109negative regulation of cell size (GO:0045792)2.71069647
110positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.70738384
111mRNA stabilization (GO:0048255)2.70401579
112RNA stabilization (GO:0043489)2.70401579
1133-UTR-mediated mRNA stabilization (GO:0070935)2.69582605
114regulation of mitotic spindle organization (GO:0060236)2.69359336
115vascular endothelial growth factor signaling pathway (GO:0038084)2.69318267
116protein localization to endoplasmic reticulum (GO:0070972)2.69238051
117snRNA metabolic process (GO:0016073)2.69181411
118folic acid metabolic process (GO:0046655)2.68999186
119regulation of RNA export from nucleus (GO:0046831)2.68851078
120positive regulation of epidermal cell differentiation (GO:0045606)2.67396842
121mitotic metaphase plate congression (GO:0007080)2.67080217
122positive regulation of histone deacetylation (GO:0031065)2.66829183
123histone mRNA catabolic process (GO:0071044)2.66264712
124telomere maintenance via semi-conservative replication (GO:0032201)2.66094994
125positive regulation of B cell differentiation (GO:0045579)2.64045684
126nucleobase biosynthetic process (GO:0046112)2.63506778
127poly(A)+ mRNA export from nucleus (GO:0016973)2.63462943
128nuclear envelope organization (GO:0006998)2.62889890
129response to interleukin-15 (GO:0070672)2.62794477
130negative regulation of mRNA processing (GO:0050686)2.62739498
131positive regulation of chromosome segregation (GO:0051984)2.62672204
132positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61409887
133negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.60171530
134rRNA processing (GO:0006364)2.60054211
135mitotic G1 DNA damage checkpoint (GO:0031571)2.59530302
136snRNA processing (GO:0016180)2.58849970
137negative regulation of mRNA metabolic process (GO:1903312)2.58517417
138regulation of activated T cell proliferation (GO:0046006)2.57044162
139regulation of isotype switching to IgG isotypes (GO:0048302)2.56171271
140viral transcription (GO:0019083)2.55680240
141chromatin assembly (GO:0031497)2.53858681
142regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53358383
143positive regulation of lymphocyte apoptotic process (GO:0070230)2.52840383
144regulation of interleukin-12 biosynthetic process (GO:0045075)2.52639079
145spliceosomal tri-snRNP complex assembly (GO:0000244)2.52145822
146positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.51983147
147cellular response to interleukin-15 (GO:0071350)2.51333355
148DNA replication checkpoint (GO:0000076)2.51186016
149male genitalia development (GO:0030539)2.50887783
150cellular response to gamma radiation (GO:0071480)2.50846108
151regulation of B cell differentiation (GO:0045577)2.50744669
152cellular response to prostaglandin stimulus (GO:0071379)2.50518418
153translational termination (GO:0006415)2.49759718
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.49487546
155negative regulation of phagocytosis (GO:0050765)2.49161706
156rRNA metabolic process (GO:0016072)2.48277410
157ncRNA 3-end processing (GO:0043628)2.48043873
158translesion synthesis (GO:0019985)2.48004153
159regulation of protein deacetylation (GO:0090311)2.47852635
160histone H3 acetylation (GO:0043966)2.47830139
161telomere maintenance via recombination (GO:0000722)2.46551073
162determination of adult lifespan (GO:0008340)2.46369120
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.45719202
164T cell apoptotic process (GO:0070231)2.45643089
165histone H3-K4 methylation (GO:0051568)2.44880106
166interferon-gamma production (GO:0032609)2.44585166
167DNA topological change (GO:0006265)2.43033869
168mitotic recombination (GO:0006312)2.42779681
169peptidyl-lysine dimethylation (GO:0018027)2.42411174
170attachment of spindle microtubules to kinetochore (GO:0008608)2.42037860
171mRNA cleavage (GO:0006379)2.41487039
172ribonucleoprotein complex biogenesis (GO:0022613)2.39226977
173cullin deneddylation (GO:0010388)10.7042037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63718725
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86685221
3MYC_22102868_ChIP-Seq_BL_Human3.61069010
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.55414657
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80614281
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75999673
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.74344955
8VDR_21846776_ChIP-Seq_THP-1_Human2.51464150
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.32290333
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31870836
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25805971
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18679651
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17049039
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04172126
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.01782930
16CIITA_25753668_ChIP-Seq_RAJI_Human1.99478180
17ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90443089
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.88974072
19MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85204813
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81480596
21MAF_26560356_Chip-Seq_TH1_Human1.81371817
22UTX_26944678_Chip-Seq_JUKART_Human1.80994234
23TCF7_22412390_ChIP-Seq_EML_Mouse1.79736080
24E2F1_21310950_ChIP-Seq_MCF-7_Human1.75828950
25ELF1_20517297_ChIP-Seq_JURKAT_Human1.75248037
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74882536
27* MYB_26560356_Chip-Seq_TH1_Human1.70889719
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.70866357
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.70305585
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.67652423
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67201248
32LXR_22292898_ChIP-Seq_THP-1_Human1.65459975
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.65408867
34XRN2_22483619_ChIP-Seq_HELA_Human1.65313293
35SCL_19346495_ChIP-Seq_HPC-7_Human1.65026961
36MYB_26560356_Chip-Seq_TH2_Human1.64518594
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61765939
38TP63_17297297_ChIP-ChIP_HaCaT_Human1.61111972
39P68_20966046_ChIP-Seq_HELA_Human1.58660792
40* RUNX1_22412390_ChIP-Seq_EML_Mouse1.56191037
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54976634
42* SPI1_23547873_ChIP-Seq_NB4_Human1.50821884
43FOXP3_21729870_ChIP-Seq_TREG_Human1.49750457
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49587744
45* KDM2B_26808549_Chip-Seq_DND41_Human1.48425569
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46277878
47VDR_23849224_ChIP-Seq_CD4+_Human1.46209171
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.45559045
49* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44728168
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43123789
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.42491540
52KDM5A_27292631_Chip-Seq_BREAST_Human1.41212951
53BCOR_27268052_Chip-Seq_Bcells_Human1.41212041
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40861927
55* PHF8_20622854_ChIP-Seq_HELA_Human1.39638583
56BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.39482689
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.38979164
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.38649595
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38429379
60VDR_24763502_ChIP-Seq_THP-1_Human1.37247337
61MAF_26560356_Chip-Seq_TH2_Human1.37017588
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.36835255
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.36335374
64* E2F1_20622854_ChIP-Seq_HELA_Human1.35009553
65E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.33218184
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.32636954
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32236579
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.31062958
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30652130
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28890228
71TFEB_21752829_ChIP-Seq_HELA_Human1.27702468
72CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27146636
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24479608
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24429977
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22408908
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22321935
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.22304776
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.21135762
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.21067991
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21007886
81NOTCH1_21737748_ChIP-Seq_TLL_Human1.20739253
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.20348060
83* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19169872
84HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.18555187
85MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18001893
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17947052
87* BCL6_27268052_Chip-Seq_Bcells_Human1.17927680
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17916055
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.17537603
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17064208
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16589766
92AR_21909140_ChIP-Seq_LNCAP_Human1.16569392
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16526686
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16078594
95KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15425840
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15303657
97* GABP_19822575_ChIP-Seq_HepG2_Human1.15201418
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14012800
99RUNX_20019798_ChIP-Seq_JUKART_Human1.13922795
100* FOXP1_21924763_ChIP-Seq_HESCs_Human1.13907334
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13621788
102NCOR1_26117541_ChIP-Seq_K562_Human1.13606115
103ELF1_17652178_ChIP-ChIP_JURKAT_Human1.13355276
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13122230
105SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13039057
106SA1_27219007_Chip-Seq_Bcells_Human1.12434491
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12247873
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11968075
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11770038
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10344286
111ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10262897
112JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.08980732
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08917536
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08524874
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08304382
116TTF2_22483619_ChIP-Seq_HELA_Human1.08238737
117SPI1_23127762_ChIP-Seq_K562_Human1.06933355
118* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06633801
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06520110
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05643746
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05519372
122TP63_19390658_ChIP-ChIP_HaCaT_Human1.04839015
123SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03682246
124THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03290146
125SMC4_20622854_ChIP-Seq_HELA_Human1.03013115
126E2F1_18555785_ChIP-Seq_MESCs_Mouse1.02896445
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02894268
128IRF8_21731497_ChIP-ChIP_J774_Mouse1.01902931
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01538268
130ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01024698
131PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00915915
132HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00869418
133DCP1A_22483619_ChIP-Seq_HELA_Human0.99983214
134* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97633600
135E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95118602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000678_abnormal_parathyroid_gland3.35804455
2MP0003111_abnormal_nucleus_morphology3.23691249
3MP0002396_abnormal_hematopoietic_system3.23366446
4MP0003693_abnormal_embryo_hatching3.21566926
5MP0010094_abnormal_chromosome_stability3.07328991
6MP0003690_abnormal_glial_cell3.05158494
7MP0008057_abnormal_DNA_replication3.02670989
8MP0003763_abnormal_thymus_physiology3.01097242
9MP0003077_abnormal_cell_cycle2.78414307
10MP0004957_abnormal_blastocyst_morpholog2.65142845
11MP0004808_abnormal_hematopoietic_stem2.55190076
12MP0002398_abnormal_bone_marrow2.34148513
13MP0001800_abnormal_humoral_immune2.33701284
14MP0010352_gastrointestinal_tract_polyps2.29798371
15MP0010307_abnormal_tumor_latency2.27953588
16MP0005076_abnormal_cell_differentiation2.19804400
17MP0000685_abnormal_immune_system2.19558646
18MP0000703_abnormal_thymus_morphology2.09138458
19MP0009278_abnormal_bone_marrow2.05033512
20MP0002876_abnormal_thyroid_physiology2.03066510
21MP0000689_abnormal_spleen_morphology2.00965880
22MP0008058_abnormal_DNA_repair1.99379611
23MP0003303_peritoneal_inflammation1.99006093
24MP0002722_abnormal_immune_system1.97926133
25MP0005671_abnormal_response_to1.97070139
26MP0001835_abnormal_antigen_presentation1.94884319
27MP0002009_preneoplasia1.94549598
28MP0001348_abnormal_lacrimal_gland1.92708281
29MP0003436_decreased_susceptibility_to1.92075956
30MP0005397_hematopoietic_system_phenotyp1.90118537
31MP0001545_abnormal_hematopoietic_system1.90118537
32MP0002420_abnormal_adaptive_immunity1.87955542
33MP0002166_altered_tumor_susceptibility1.87146150
34MP0002452_abnormal_antigen_presenting1.86355454
35MP0009333_abnormal_splenocyte_physiolog1.86057478
36MP0001819_abnormal_immune_cell1.84976060
37MP0001730_embryonic_growth_arrest1.82246869
38MP0000716_abnormal_immune_system1.82171893
39MP0002723_abnormal_immune_serum1.78087794
40MP0002405_respiratory_system_inflammati1.77628233
41MP0001790_abnormal_immune_system1.75376576
42MP0005387_immune_system_phenotype1.75376576
43MP0003300_gastrointestinal_ulcer1.72881417
44MP0008007_abnormal_cellular_replicative1.72683813
45MP0002429_abnormal_blood_cell1.69111181
46MP0000350_abnormal_cell_proliferation1.68041819
47MP0005000_abnormal_immune_tolerance1.63762781
48MP0000490_abnormal_crypts_of1.62732318
49MP0004185_abnormal_adipocyte_glucose1.59522765
50MP0002019_abnormal_tumor_incidence1.58014826
51MP0003566_abnormal_cell_adhesion1.46513850
52MP0005025_abnormal_response_to1.43071624
53MP0001873_stomach_inflammation1.41944147
54MP0004381_abnormal_hair_follicle1.40088483
55MP0001672_abnormal_embryogenesis/_devel1.39053497
56MP0005380_embryogenesis_phenotype1.39053497
57MP0005464_abnormal_platelet_physiology1.37835683
58MP0004947_skin_inflammation1.36223368
59MP0002006_tumorigenesis1.35425507
60MP0003984_embryonic_growth_retardation1.34128109
61MP0002086_abnormal_extraembryonic_tissu1.32022690
62MP0002088_abnormal_embryonic_growth/wei1.29200472
63MP0000858_altered_metastatic_potential1.29099363
64MP0003172_abnormal_lysosome_physiology1.28733979
65MP0008877_abnormal_DNA_methylation1.28609968
66MP0002080_prenatal_lethality1.28183770
67MP0010155_abnormal_intestine_physiology1.27144735
68MP0000465_gastrointestinal_hemorrhage1.25992001
69MP0004197_abnormal_fetal_growth/weight/1.25310062
70MP0001697_abnormal_embryo_size1.23993801
71MP0003705_abnormal_hypodermis_morpholog1.22786027
72MP0002163_abnormal_gland_morphology1.22563950
73MP0006082_CNS_inflammation1.22435683
74MP0000313_abnormal_cell_death1.21836332
75MP0002419_abnormal_innate_immunity1.20616333
76MP0000569_abnormal_digit_pigmentation1.19699239
77MP0009785_altered_susceptibility_to1.18063725
78MP0003866_abnormal_defecation1.15988825
79MP0009384_cardiac_valve_regurgitation1.11649980
80MP0005023_abnormal_wound_healing1.09412663
81MP0002796_impaired_skin_barrier1.08598119
82MP0002084_abnormal_developmental_patter1.07174713
83MP0004858_abnormal_nervous_system1.04770214
84MP0008961_abnormal_basal_metabolism1.01692342
85MP0001853_heart_inflammation1.01428396
86MP0001845_abnormal_inflammatory_respons1.00895886
87MP0005621_abnormal_cell_physiology1.00853849
88MP0002148_abnormal_hypersensitivity_rea1.00466853
89MP0004510_myositis1.00347382
90MP0003786_premature_aging1.00083069
91MP0005451_abnormal_body_composition0.99348678
92MP0003448_altered_tumor_morphology0.99086247
93MP0002085_abnormal_embryonic_tissue0.98466425
94MP0005501_abnormal_skin_physiology0.95648673
95MP0000750_abnormal_muscle_regeneration0.94367970
96MP0002160_abnormal_reproductive_system0.90093343
97MP0003221_abnormal_cardiomyocyte_apopto0.88825627
98MP0005174_abnormal_tail_pigmentation0.87591414
99MP0008932_abnormal_embryonic_tissue0.87381456
100MP0004233_abnormal_muscle_weight0.87240866
101MP0003123_paternal_imprinting0.85946800
102MP0003183_abnormal_peptide_metabolism0.85798734
103MP0005384_cellular_phenotype0.83873222
104MP0003943_abnormal_hepatobiliary_system0.82611262
105MP0005310_abnormal_salivary_gland0.82384219
106MP0002877_abnormal_melanocyte_morpholog0.82327223
107MP0005075_abnormal_melanosome_morpholog0.81999261
108MP0003787_abnormal_imprinting0.81723248
109MP0008770_decreased_survivor_rate0.81537930
110MP0000371_diluted_coat_color0.77906621
111MP0001986_abnormal_taste_sensitivity0.77618122
112MP0001915_intracranial_hemorrhage0.77009091
113MP0000733_abnormal_muscle_development0.75525946
114MP0001851_eye_inflammation0.73201810
115MP0009765_abnormal_xenobiotic_induced0.72832478
116MP0003567_abnormal_fetal_cardiomyocyte0.72127222
117MP0001881_abnormal_mammary_gland0.71341904
118MP0004130_abnormal_muscle_cell0.70102738
119MP0001533_abnormal_skeleton_physiology0.68912586
120MP0002925_abnormal_cardiovascular_devel0.68834510
121MP0008995_early_reproductive_senescence0.67346647
122MP0004264_abnormal_extraembryonic_tissu0.67161047
123MP0002933_joint_inflammation0.67034544
124MP0001849_ear_inflammation0.65458732
125MP0001346_abnormal_lacrimal_gland0.64384959
126MP0000477_abnormal_intestine_morphology0.63834300
127MP0008469_abnormal_protein_level0.59204894
128MP0009931_abnormal_skin_appearance0.57931230
129MP0006036_abnormal_mitochondrial_physio0.57457677

Predicted human phenotypes

RankGene SetZ-score
1Global brain atrophy (HP:0002283)5.13256632
2Gastrointestinal stroma tumor (HP:0100723)4.65557930
3Abnormality of the columella (HP:0009929)4.49351147
4Rectal prolapse (HP:0002035)4.11276000
5T lymphocytopenia (HP:0005403)4.08155203
6Abnormality of T cell number (HP:0011839)3.88664717
7Abnormality of the fingertips (HP:0001211)3.80644484
8Cortical visual impairment (HP:0100704)3.73192572
9Lower limb hyperreflexia (HP:0002395)3.65682562
10Broad distal phalanx of finger (HP:0009836)3.53411396
11Hyperthyroidism (HP:0000836)3.44439639
12Recurrent viral infections (HP:0004429)3.43450802
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.39022224
14Seborrheic dermatitis (HP:0001051)3.20552832
15Abnormality of T cells (HP:0002843)3.14458243
16Recurrent fungal infections (HP:0002841)3.09067725
17Progressive muscle weakness (HP:0003323)3.05748007
18Ependymoma (HP:0002888)3.05404138
19Thrombocytosis (HP:0001894)2.95224202
20Basal cell carcinoma (HP:0002671)2.89426801
21Abnormality of homocysteine metabolism (HP:0010919)2.88182597
22Homocystinuria (HP:0002156)2.88182597
23Cleft eyelid (HP:0000625)2.83218227
24IgM deficiency (HP:0002850)2.80204607
25Pallor (HP:0000980)2.80053964
26Hypertensive crisis (HP:0100735)2.76075487
27Prominent nose (HP:0000448)2.74455982
28Emphysema (HP:0002097)2.68765880
29Aplasia/Hypoplasia of the thymus (HP:0010515)2.65891451
30Thin bony cortex (HP:0002753)2.65676117
31Recurrent bronchitis (HP:0002837)2.63598211
32Panhypogammaglobulinemia (HP:0003139)2.63326673
33Long palpebral fissure (HP:0000637)2.62033676
34Recurrent cutaneous fungal infections (HP:0011370)2.57490979
35Chronic mucocutaneous candidiasis (HP:0002728)2.57490979
36Pustule (HP:0200039)2.57422872
37Delayed epiphyseal ossification (HP:0002663)2.57222406
38Volvulus (HP:0002580)2.57134953
39Abnormality of T cell physiology (HP:0011840)2.53519819
40Nasal polyposis (HP:0100582)2.53332960
41Leukopenia (HP:0001882)2.49835295
42Increased density of long bones (HP:0006392)2.46298734
43Amaurosis fugax (HP:0100576)2.44428020
44Cellulitis (HP:0100658)2.42770312
45Aplasia/Hypoplasia of the earlobes (HP:0009906)2.40931196
46Rough bone trabeculation (HP:0100670)2.40751440
47Autoimmune thrombocytopenia (HP:0001973)2.38381810
48Long eyelashes (HP:0000527)2.35984399
49Combined immunodeficiency (HP:0005387)2.34674545
50Macrocytic anemia (HP:0001972)2.33714884
51Lymphoma (HP:0002665)2.31195655
52Gastrointestinal inflammation (HP:0004386)2.30856577
53Abnormality of the nasal mucosa (HP:0000433)2.28760609
54Chronic otitis media (HP:0000389)2.27466760
55Myelodysplasia (HP:0002863)2.27407127
56Severe combined immunodeficiency (HP:0004430)2.21622493
57High pitched voice (HP:0001620)2.21332484
58Spontaneous hematomas (HP:0007420)2.20855849
59Ragged-red muscle fibers (HP:0003200)2.20602139
60Vasculitis (HP:0002633)2.18482854
61Eczematoid dermatitis (HP:0000976)2.15697029
62Deviation of the thumb (HP:0009603)2.15304970
63Proximal placement of thumb (HP:0009623)2.15008192
64Poikiloderma (HP:0001029)2.13627112
65Broad palm (HP:0001169)2.12013402
66Selective tooth agenesis (HP:0001592)2.09907291
67Chest pain (HP:0100749)2.09575961
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.09536626
69Hyperacusis (HP:0010780)2.09297981
70Heterotopia (HP:0002282)2.08738615
71Hypoparathyroidism (HP:0000829)2.08646092
72Horseshoe kidney (HP:0000085)2.08364618
73Status epilepticus (HP:0002133)2.08015194
74Granulocytopenia (HP:0001913)2.07871631
75Cerebral aneurysm (HP:0004944)2.07603894
76Astrocytoma (HP:0009592)2.05156909
77Abnormality of the astrocytes (HP:0100707)2.05156909
78Elevated erythrocyte sedimentation rate (HP:0003565)2.05088592
79Inflammation of the large intestine (HP:0002037)2.04895955
80Entropion (HP:0000621)2.04845446
81Type I diabetes mellitus (HP:0100651)2.02575764
82Abnormality of pyrimidine metabolism (HP:0004353)2.02093530
83Mediastinal lymphadenopathy (HP:0100721)2.01885426
84Lymphopenia (HP:0001888)2.01481017
85Abnormality of cells of the erythroid lineage (HP:0012130)2.00985954
86Deep palmar crease (HP:0006191)2.00185044
87IgG deficiency (HP:0004315)1.99656786
88Rib fusion (HP:0000902)1.99002844
89Restrictive lung disease (HP:0002091)1.98718474
90Thyroiditis (HP:0100646)1.98515978
91Abnormality of the anterior horn cell (HP:0006802)1.98223320
92Degeneration of anterior horn cells (HP:0002398)1.98223320
93Ectopic kidney (HP:0000086)1.96978917
94Increased nuchal translucency (HP:0010880)1.96541397
95Truncus arteriosus (HP:0001660)1.96395113
96Medulloblastoma (HP:0002885)1.96363129
97Microvesicular hepatic steatosis (HP:0001414)1.96240189
98Papilloma (HP:0012740)1.96204645
99Verrucae (HP:0200043)1.96204645
100Reticulocytopenia (HP:0001896)1.95556957
101Encephalitis (HP:0002383)1.95470774
102Abnormal number of erythroid precursors (HP:0012131)1.94329244
103Agnosia (HP:0010524)1.94328316
104Spinal muscular atrophy (HP:0007269)1.92992733
105Recurrent abscess formation (HP:0002722)1.92689791
106Birth length less than 3rd percentile (HP:0003561)1.92128325
107Cafe-au-lait spot (HP:0000957)1.92030984
108Squamous cell carcinoma (HP:0002860)1.91947887
109Urethral obstruction (HP:0000796)1.91416261
110Atelectasis (HP:0100750)1.90886528
111Hypocalcemia (HP:0002901)1.90723775
112Breast aplasia (HP:0100783)1.90575352
113Chromsome breakage (HP:0040012)1.88835033
114Lymphangioma (HP:0100764)1.88035688
115Meningitis (HP:0001287)1.87523377
116B lymphocytopenia (HP:0010976)1.87360774
117Abnormality of B cell number (HP:0010975)1.87360774
118IgA deficiency (HP:0002720)1.86885791
119Agammaglobulinemia (HP:0004432)1.86054198
120Impulsivity (HP:0100710)1.85960410
121Abnormality of the thymus (HP:0000777)1.85933287
122Absent thumb (HP:0009777)1.85734355
123Asplenia (HP:0001746)1.85585716
124Abnormality of the lower motor neuron (HP:0002366)1.85521840
125Colitis (HP:0002583)1.84527460
126Prolonged bleeding time (HP:0003010)1.84226786
127Abnormality of DNA repair (HP:0003254)1.84089705
128Ulnar bowing (HP:0003031)1.83946728
129Neonatal hypoglycemia (HP:0001998)1.83917834
130Neoplasm of the adrenal cortex (HP:0100641)1.83906273
131Orchitis (HP:0100796)1.81360089
132Abnormal trabecular bone morphology (HP:0100671)1.81009922
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.80674497
134Cholelithiasis (HP:0001081)1.79619350
135Overlapping toe (HP:0001845)1.79030967
136Acute lymphatic leukemia (HP:0006721)1.78216735
137Testicular atrophy (HP:0000029)1.78179651
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77514876
139Skin tags (HP:0010609)1.75149609
140Aplasia/Hypoplasia of the breasts (HP:0010311)1.73430270
141Abnormality of chromosome stability (HP:0003220)1.72527421
142Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71672017
143Hypochromic anemia (HP:0001931)1.71147190
144Premature graying of hair (HP:0002216)1.70579818
145Aplasia/Hypoplasia of the spleen (HP:0010451)1.69419206
146Wide cranial sutures (HP:0010537)1.69413213
147Abnormal platelet volume (HP:0011876)1.67330192
148Hand muscle atrophy (HP:0009130)1.66908362
149Ureteral stenosis (HP:0000071)1.66529440
150Petechiae (HP:0000967)1.66144701
151Rhabdomyosarcoma (HP:0002859)1.65575202
152Chronic obstructive pulmonary disease (HP:0006510)1.65097837
153Obstructive lung disease (HP:0006536)1.65097837
154Albinism (HP:0001022)1.64787697
155Increased IgE level (HP:0003212)1.64407641
156Myositis (HP:0100614)1.64028049
157Leukocytosis (HP:0001974)1.64008687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.39689678
2PRKD24.05679874
3MAP4K13.89806335
4CDK123.73475692
5NUAK13.54657159
6EEF2K3.18794014
7PKN22.77557360
8NEK22.41932796
9MAP3K102.30233469
10CDC72.29221698
11SMG12.27385120
12PRKCH2.21016789
13STK102.12739449
14PRPF4B1.95155334
15ITK1.88920591
16GRK61.84558580
17ERN11.79322074
18JAK31.78538504
19MAP3K141.75779305
20MAP2K31.74019980
21WEE11.65708050
22BRD41.63910137
23TRIB31.63863220
24TXK1.59869382
25SIK21.59034933
26ZAP701.55810445
27BUB11.48166896
28RPS6KB21.48033782
29TAOK11.44825060
30FLT31.43869105
31ALK1.42863294
32BTK1.42765596
33RIPK41.41488717
34TYK21.41171785
35CDK41.41129209
36PASK1.41018088
37PIM11.36789092
38ATR1.27850828
39ICK1.26248827
40CDK71.25478254
41MAP2K21.24434074
42KIT1.23087876
43LRRK21.22450339
44CSK1.21076642
45VRK11.15222293
46TEC1.08332484
47TTN1.07809970
48KDR1.06754685
49TSSK61.05282245
50FGFR41.04495891
51BRAF1.04037100
52RPS6KA41.03275466
53TNK21.02807266
54MAP3K81.00620471
55PTK60.99058438
56CHEK10.98160486
57HCK0.96453328
58TESK10.94992969
59MTOR0.94659396
60CDK60.93462801
61STK40.91975874
62LCK0.91056341
63SYK0.88318744
64TTK0.87115859
65JAK10.86906328
66CSF1R0.86685665
67MAP3K70.85006494
68FGFR30.81389348
69AURKB0.79419504
70PLK10.77975481
71IKBKE0.77899479
72CHUK0.77846587
73IRAK30.77793081
74MAP3K130.76695242
75NME10.75841189
76CAMK1D0.75360065
77TAOK20.75320173
78PAK40.72115935
79FES0.71830564
80CAMK1G0.71554335
81CDK20.71280421
82MAP3K110.70446878
83MARK30.69366213
84BRSK20.67484819
85IKBKB0.66064163
86EIF2AK10.64881497
87ATM0.64876449
88SIK10.63612250
89NME20.62904972
90CHEK20.61978816
91RPS6KA60.60673685
92BCKDK0.60407804
93PRKD10.60362091
94RPS6KL10.59978774
95RPS6KC10.59978774
96PIM20.58977847
97MARK20.58343370
98MAPK110.57207753
99SCYL20.55618116
100TLK10.53934825
101IRAK40.52997047
102TBK10.51810839
103JAK20.51545812
104RIPK10.49213765
105BMX0.48885008
106CLK10.48689912
107HIPK20.48106504
108TGFBR10.48040418
109PDPK10.47913166
110SRPK10.47743843
111LYN0.47224339
112NEK10.47146639
113CDK90.47119531
114MAP3K30.46449915
115MELK0.46369643
116AURKA0.46320640
117PLK40.43788649
118PRKCI0.43248431
119DYRK30.42377468
120NEK60.42290119
121PAK20.42250027
122UHMK10.42090595
123PNCK0.40909940
124RPS6KA20.40903822
125RPS6KA10.40736865
126PDK10.40296756
127CDK10.38387332
128STK30.38251862
129RAF10.37892965
130TAOK30.37779120
131BRSK10.37684931
132TESK20.37368271
133CSNK2A20.36757964
134CDC42BPA0.33314248

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.14985707
2Mismatch repair_Homo sapiens_hsa034302.72647691
3Primary immunodeficiency_Homo sapiens_hsa053402.61402629
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58868112
5Base excision repair_Homo sapiens_hsa034102.37293578
6RNA transport_Homo sapiens_hsa030132.24819888
7Spliceosome_Homo sapiens_hsa030402.20246478
8Cell cycle_Homo sapiens_hsa041101.94546234
9One carbon pool by folate_Homo sapiens_hsa006701.87803590
10Antigen processing and presentation_Homo sapiens_hsa046121.85730216
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84299378
12B cell receptor signaling pathway_Homo sapiens_hsa046621.83723590
13Sulfur relay system_Homo sapiens_hsa041221.70541282
14mRNA surveillance pathway_Homo sapiens_hsa030151.67553976
15T cell receptor signaling pathway_Homo sapiens_hsa046601.65545339
16Homologous recombination_Homo sapiens_hsa034401.64114799
17Measles_Homo sapiens_hsa051621.52661247
18Non-homologous end-joining_Homo sapiens_hsa034501.50034971
19NF-kappa B signaling pathway_Homo sapiens_hsa040641.49894739
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47447635
21Nucleotide excision repair_Homo sapiens_hsa034201.46149258
22Herpes simplex infection_Homo sapiens_hsa051681.43852255
23p53 signaling pathway_Homo sapiens_hsa041151.42604716
24Ribosome_Homo sapiens_hsa030101.42138484
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37242112
26Chronic myeloid leukemia_Homo sapiens_hsa052201.34839819
27Fanconi anemia pathway_Homo sapiens_hsa034601.32147263
28Autoimmune thyroid disease_Homo sapiens_hsa053201.31118507
29Viral carcinogenesis_Homo sapiens_hsa052031.30879563
30RNA degradation_Homo sapiens_hsa030181.30560863
31Leishmaniasis_Homo sapiens_hsa051401.29798836
32Epstein-Barr virus infection_Homo sapiens_hsa051691.27113965
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26033065
34mTOR signaling pathway_Homo sapiens_hsa041501.25505563
35Osteoclast differentiation_Homo sapiens_hsa043801.25099523
36Hematopoietic cell lineage_Homo sapiens_hsa046401.22805689
37Hepatitis B_Homo sapiens_hsa051611.18699746
38Apoptosis_Homo sapiens_hsa042101.16626780
39Acute myeloid leukemia_Homo sapiens_hsa052211.15012033
40HTLV-I infection_Homo sapiens_hsa051661.14114844
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13278976
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.12123832
43Small cell lung cancer_Homo sapiens_hsa052221.10683999
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.03365154
45Viral myocarditis_Homo sapiens_hsa054161.02849563
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99460335
47RNA polymerase_Homo sapiens_hsa030200.98001589
48Non-small cell lung cancer_Homo sapiens_hsa052230.97076965
49Lysine degradation_Homo sapiens_hsa003100.96361737
50Notch signaling pathway_Homo sapiens_hsa043300.96260918
51Toxoplasmosis_Homo sapiens_hsa051450.94482372
52Pancreatic cancer_Homo sapiens_hsa052120.93009677
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.92991329
54MicroRNAs in cancer_Homo sapiens_hsa052060.92078791
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91939965
56Influenza A_Homo sapiens_hsa051640.90532866
57Shigellosis_Homo sapiens_hsa051310.90513019
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90209311
59Pyrimidine metabolism_Homo sapiens_hsa002400.87703386
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.87460659
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87056001
62Colorectal cancer_Homo sapiens_hsa052100.86597154
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85303747
64Allograft rejection_Homo sapiens_hsa053300.84131619
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84049358
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.84003838
67Systemic lupus erythematosus_Homo sapiens_hsa053220.82562569
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82026894
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.80262443
70Legionellosis_Homo sapiens_hsa051340.80068298
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.79073308
72HIF-1 signaling pathway_Homo sapiens_hsa040660.75978547
73Graft-versus-host disease_Homo sapiens_hsa053320.73265765
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71747330
75Biosynthesis of amino acids_Homo sapiens_hsa012300.70938198
76Chemokine signaling pathway_Homo sapiens_hsa040620.70342368
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68697642
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68336252
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68167414
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.67593269
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66196771
82TNF signaling pathway_Homo sapiens_hsa046680.66092557
83Platelet activation_Homo sapiens_hsa046110.65838070
84VEGF signaling pathway_Homo sapiens_hsa043700.65668488
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64711217
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63253763
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61176649
88Oocyte meiosis_Homo sapiens_hsa041140.58820917
89Prolactin signaling pathway_Homo sapiens_hsa049170.58250621
90Purine metabolism_Homo sapiens_hsa002300.58032609
91Tuberculosis_Homo sapiens_hsa051520.57296809
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55679669
93Pentose phosphate pathway_Homo sapiens_hsa000300.55185958
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55067227
95FoxO signaling pathway_Homo sapiens_hsa040680.54182471
96Insulin resistance_Homo sapiens_hsa049310.53870073
97Prion diseases_Homo sapiens_hsa050200.53311754
98Bladder cancer_Homo sapiens_hsa052190.52160832
99Thyroid cancer_Homo sapiens_hsa052160.51273970
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51075243
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50475535
102Cysteine and methionine metabolism_Homo sapiens_hsa002700.50099900
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48555427
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48088759
105Proteoglycans in cancer_Homo sapiens_hsa052050.47675996
106Type I diabetes mellitus_Homo sapiens_hsa049400.44362190
107Prostate cancer_Homo sapiens_hsa052150.44273739
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42524469
109Hepatitis C_Homo sapiens_hsa051600.42205236
110Pathways in cancer_Homo sapiens_hsa052000.41873016
111Asthma_Homo sapiens_hsa053100.41525059
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41029033
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39853732
114Basal transcription factors_Homo sapiens_hsa030220.38441968
115Type II diabetes mellitus_Homo sapiens_hsa049300.37242830
116MAPK signaling pathway_Homo sapiens_hsa040100.37013083
117Insulin signaling pathway_Homo sapiens_hsa049100.36054277
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.35816820
119Fructose and mannose metabolism_Homo sapiens_hsa000510.34091121

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