KRIT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sex differentiation (GO:0007548)9.51259397
2stress granule assembly (GO:0034063)8.19956582
3regulation of interleukin-13 production (GO:0032656)8.12725656
4cholesterol catabolic process (GO:0006707)7.70375769
5sterol catabolic process (GO:0016127)7.70375769
6alternative mRNA splicing, via spliceosome (GO:0000380)7.38866018
7cerebellar Purkinje cell differentiation (GO:0021702)7.34907977
8regulation of interleukin-5 production (GO:0032674)6.90960660
9positive regulation of vasculogenesis (GO:2001214)6.74739942
10negative regulation of receptor-mediated endocytosis (GO:0048261)6.59059144
11ADP metabolic process (GO:0046031)6.45261884
12monoubiquitinated protein deubiquitination (GO:0035520)6.19634976
13nucleoside diphosphate catabolic process (GO:0009134)6.19589172
14kynurenine metabolic process (GO:0070189)6.09554434
15regulation of metalloenzyme activity (GO:0048552)5.78762442
16lipid particle organization (GO:0034389)5.60848451
17indole-containing compound catabolic process (GO:0042436)5.49818467
18indolalkylamine catabolic process (GO:0046218)5.49818467
19tryptophan catabolic process (GO:0006569)5.49818467
20regulation of vasculogenesis (GO:2001212)5.38009512
21mitotic metaphase plate congression (GO:0007080)5.19512144
22maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.09462802
23bile acid biosynthetic process (GO:0006699)4.83014618
24tryptophan metabolic process (GO:0006568)4.76923866
25regulation of action potential (GO:0098900)4.66543677
26acrosome assembly (GO:0001675)4.58746318
27negative regulation of DNA-dependent DNA replication (GO:2000104)4.40405362
28replication fork processing (GO:0031297)4.38675904
29meiotic chromosome segregation (GO:0045132)4.28792625
30protein autoprocessing (GO:0016540)4.19246681
31metaphase plate congression (GO:0051310)4.18403886
32mitotic sister chromatid cohesion (GO:0007064)4.17717918
33DNA damage response, signal transduction resulting in transcription (GO:0042772)4.11732270
34response to X-ray (GO:0010165)4.10241575
35regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.07965621
36microtubule depolymerization (GO:0007019)4.07582943
37somite rostral/caudal axis specification (GO:0032525)4.03873883
38regulation of spindle organization (GO:0090224)4.03806280
39negative regulation of mast cell activation (GO:0033004)4.00244866
40poly(A)+ mRNA export from nucleus (GO:0016973)3.97516015
41kinetochore assembly (GO:0051382)3.95217237
42synaptic transmission, cholinergic (GO:0007271)3.94027624
43protein K6-linked ubiquitination (GO:0085020)3.93793508
44regulation of triglyceride catabolic process (GO:0010896)3.93233666
45snRNA transcription (GO:0009301)3.92076840
46regulation of histone H3-K27 methylation (GO:0061085)3.91526366
47sister chromatid cohesion (GO:0007062)3.89620993
48lipid translocation (GO:0034204)3.89528293
49phospholipid translocation (GO:0045332)3.89528293
50regulation of sequestering of triglyceride (GO:0010889)3.87428526
51estrogen biosynthetic process (GO:0006703)3.83996197
52regulation of RNA export from nucleus (GO:0046831)3.80946510
53negative regulation of T cell differentiation (GO:0045581)3.80775083
54neural tube formation (GO:0001841)3.79777705
55DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.78114714
56positive regulation of fatty acid beta-oxidation (GO:0032000)3.75159053
57neuronal action potential propagation (GO:0019227)3.74111288
58seminiferous tubule development (GO:0072520)3.70668698
59regulation of transcription from RNA polymerase I promoter (GO:0006356)3.70591535
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.69755843
61indolalkylamine metabolic process (GO:0006586)3.67938274
62central nervous system projection neuron axonogenesis (GO:0021952)3.67153316
63cell differentiation in hindbrain (GO:0021533)3.64250272
64inner cell mass cell proliferation (GO:0001833)3.64059026
65positive regulation of heat generation (GO:0031652)3.63857252
66purine ribonucleoside diphosphate metabolic process (GO:0009179)3.60491572
67purine nucleoside diphosphate metabolic process (GO:0009135)3.60491572
68kinetochore organization (GO:0051383)3.57214312
69steroid catabolic process (GO:0006706)3.55804817
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.54764935
71negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.54073322
72nuclear pore complex assembly (GO:0051292)3.50119499
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50007602
74regulation of receptor internalization (GO:0002090)3.46130517
75regulation of type 2 immune response (GO:0002828)3.44684430
76regulation of superoxide metabolic process (GO:0090322)3.44549121
77phosphatidylglycerol biosynthetic process (GO:0006655)3.42659148
78L-fucose catabolic process (GO:0042355)3.40515561
79fucose catabolic process (GO:0019317)3.40515561
80L-fucose metabolic process (GO:0042354)3.40515561
81regulation of germinal center formation (GO:0002634)3.39731459
82regulation of meiosis I (GO:0060631)3.38945680
83negative regulation of organ growth (GO:0046621)3.36221769
84regulation of mitotic spindle organization (GO:0060236)3.35934568
85establishment of chromosome localization (GO:0051303)3.35761453
86cellular response to gamma radiation (GO:0071480)3.34507654
87oocyte maturation (GO:0001556)3.30402432
88response to redox state (GO:0051775)3.30125995
89central nervous system neuron axonogenesis (GO:0021955)3.30101073
90DNA strand renaturation (GO:0000733)3.29430316
91regulation of exit from mitosis (GO:0007096)3.23750644
92DNA synthesis involved in DNA repair (GO:0000731)3.23136637
93DNA replication checkpoint (GO:0000076)3.22488232
94regulation of double-strand break repair via homologous recombination (GO:0010569)3.20796613
95positive regulation of triglyceride biosynthetic process (GO:0010867)3.20403534
96regulation of gene silencing by RNA (GO:0060966)3.18339328
97regulation of posttranscriptional gene silencing (GO:0060147)3.18339328
98regulation of gene silencing by miRNA (GO:0060964)3.18339328
99one-carbon compound transport (GO:0019755)3.17935560
100male meiosis I (GO:0007141)3.17096028
101aromatic amino acid family catabolic process (GO:0009074)3.17024691
102NAD biosynthetic process (GO:0009435)3.15560575
103cellular ketone body metabolic process (GO:0046950)3.14111691
104nuclear pore organization (GO:0006999)3.12798875
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.09997568
106termination of RNA polymerase III transcription (GO:0006386)3.09997568
107vitamin transmembrane transport (GO:0035461)3.08998657
108female gonad development (GO:0008585)3.07933618
109amine catabolic process (GO:0009310)3.05251132
110cellular biogenic amine catabolic process (GO:0042402)3.05251132
111response to lipoprotein particle (GO:0055094)3.04938317
112regulation of heat generation (GO:0031650)3.04843707
113regulation of phospholipid biosynthetic process (GO:0071071)3.03461414
114centrosome duplication (GO:0051298)3.01017349
115regulation of nucleobase-containing compound transport (GO:0032239)3.00995360
116regulation of response to reactive oxygen species (GO:1901031)3.00263903
117meiosis I (GO:0007127)2.99744707
118reciprocal meiotic recombination (GO:0007131)2.99633972
119reciprocal DNA recombination (GO:0035825)2.99633972
120mitotic chromosome condensation (GO:0007076)2.98613747
121regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.98097651
122L-methionine salvage (GO:0071267)2.97253863
123L-methionine biosynthetic process (GO:0071265)2.97253863
124amino acid salvage (GO:0043102)2.97253863
125positive regulation of fatty acid oxidation (GO:0046321)2.96703687
126regulation of sarcomere organization (GO:0060297)2.95859424
127histone H3-K36 demethylation (GO:0070544)2.95493071
128histone demethylation (GO:0016577)2.93679434
129DNA demethylation (GO:0080111)2.93632575
130histone H3-K9 methylation (GO:0051567)2.91732452
131positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.91717986
132CENP-A containing nucleosome assembly (GO:0034080)2.89005781
133pore complex assembly (GO:0046931)2.88758889
134ketone body metabolic process (GO:1902224)2.88655919
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.88298667
136negative regulation of fibroblast apoptotic process (GO:2000270)2.88055689
137N-terminal protein amino acid acetylation (GO:0006474)2.86082047
138cardiolipin metabolic process (GO:0032048)2.85967127
139histone lysine demethylation (GO:0070076)2.85765226
140regulation of mitotic spindle checkpoint (GO:1903504)2.85488365
141regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85488365
142spindle checkpoint (GO:0031577)2.84696135
143metallo-sulfur cluster assembly (GO:0031163)2.83731931
144iron-sulfur cluster assembly (GO:0016226)2.83731931
145detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83198455
146cell migration involved in gastrulation (GO:0042074)2.82382133
147positive regulation of chromosome segregation (GO:0051984)2.80466925
148microtubule nucleation (GO:0007020)2.80242126
149modulation by virus of host process (GO:0019054)2.79081007
150positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.79041504
151positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.79041504
152positive regulation of mitotic sister chromatid separation (GO:1901970)2.79041504
153bile acid metabolic process (GO:0008206)2.77193205
154histone exchange (GO:0043486)2.77145783
155negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.75187616
156killing of cells of other organism (GO:0031640)2.74888057
157N-terminal protein amino acid modification (GO:0031365)2.74025803
158histone H3-K4 trimethylation (GO:0080182)2.73032646
159negative regulation of cell aging (GO:0090344)2.70305188
160negative regulation of keratinocyte proliferation (GO:0010839)2.70194492
161resolution of meiotic recombination intermediates (GO:0000712)2.70153978
162regulation of retinoic acid receptor signaling pathway (GO:0048385)2.70046273
163DNA replication-independent nucleosome organization (GO:0034724)2.68227549
164DNA replication-independent nucleosome assembly (GO:0006336)2.68227549
165histone H2B ubiquitination (GO:0033523)2.68083817
166chromatin remodeling at centromere (GO:0031055)2.66601354
167regulation of fibroblast apoptotic process (GO:2000269)2.63493013
168regulation of chromosome segregation (GO:0051983)2.63427780
169response to UV-C (GO:0010225)2.63313266
170* regulation of establishment of cell polarity (GO:2000114)2.63211513
171microtubule polymerization or depolymerization (GO:0031109)2.63057147
172peptidyl-lysine trimethylation (GO:0018023)2.61855410
173protein demethylation (GO:0006482)2.61661358
174protein dealkylation (GO:0008214)2.61661358
175positive regulation of granulocyte differentiation (GO:0030854)2.58742991
176negative regulation of hormone metabolic process (GO:0032351)2.56993154
177negative regulation of hormone biosynthetic process (GO:0032353)2.56993154
178myoblast migration (GO:0051451)2.56823252
179response to gamma radiation (GO:0010332)2.56735362
180regulation of DNA-dependent DNA replication (GO:0090329)2.55428354
181DNA double-strand break processing (GO:0000729)2.54466709
182mitotic G2/M transition checkpoint (GO:0044818)2.54337620
183mismatch repair (GO:0006298)2.52136628
184negative regulation of DNA replication (GO:0008156)2.52115855
185regulation of sister chromatid cohesion (GO:0007063)2.51361373
186chromosome segregation (GO:0007059)2.49176480
187rRNA methylation (GO:0031167)2.49102573
188DNA-dependent DNA replication (GO:0006261)2.48957308
189pyrimidine dimer repair (GO:0006290)2.48502204
190regulation of memory T cell differentiation (GO:0043380)12.5979771
191cytoplasmic mRNA processing body assembly (GO:0033962)11.8346490
192negative regulation of multicellular organism growth (GO:0040015)11.6248978
193negative regulation of type 2 immune response (GO:0002829)10.1616685
194regulation of MHC class I biosynthetic process (GO:0045343)10.1061183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_22108803_ChIP-Seq_LS180_Human4.22086894
2E2F7_22180533_ChIP-Seq_HELA_Human4.10301545
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.75250634
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.59838604
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.58560727
6FLI1_27457419_Chip-Seq_LIVER_Mouse3.38227179
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.15680306
8PCGF2_27294783_Chip-Seq_ESCs_Mouse3.06993132
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63080488
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.59559037
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.57119122
12BCAT_22108803_ChIP-Seq_LS180_Human2.41968773
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.41218862
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39569563
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.37143319
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.36775325
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36363542
18GBX2_23144817_ChIP-Seq_PC3_Human2.30963089
19ZNF274_21170338_ChIP-Seq_K562_Hela2.29924642
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.25712704
21* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20130739
22NFE2_27457419_Chip-Seq_LIVER_Mouse2.18930406
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18311219
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16835118
25EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.10684457
26NANOG_18555785_Chip-Seq_ESCs_Mouse2.05864167
27FUS_26573619_Chip-Seq_HEK293_Human2.04224210
28E2F4_17652178_ChIP-ChIP_JURKAT_Human1.97811934
29EZH2_22144423_ChIP-Seq_EOC_Human1.96715735
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.95526565
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90475940
32TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89350471
33EWS_26573619_Chip-Seq_HEK293_Human1.87301142
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83908734
35LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78542921
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.78223988
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.76659563
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.73693311
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73693311
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.72871616
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70295011
42SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.68171626
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.68143085
44P53_22387025_ChIP-Seq_ESCs_Mouse1.67584705
45NMYC_18555785_Chip-Seq_ESCs_Mouse1.65166404
46EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.64672583
47IGF1R_20145208_ChIP-Seq_DFB_Human1.62691459
48CMYC_18555785_Chip-Seq_ESCs_Mouse1.57599741
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55964721
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.55547601
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55236130
52OCT1_27270436_Chip-Seq_PROSTATE_Human1.55120534
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50320411
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.46608987
55RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44114815
56ZFX_18555785_Chip-Seq_ESCs_Mouse1.43512360
57IRF1_19129219_ChIP-ChIP_H3396_Human1.42547253
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41329682
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.41184942
60P300_18555785_Chip-Seq_ESCs_Mouse1.40779551
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39621376
62CDX2_22108803_ChIP-Seq_LS180_Human1.38483735
63CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38112739
64STAT3_23295773_ChIP-Seq_U87_Human1.36780340
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.36716107
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36628022
67CBP_20019798_ChIP-Seq_JUKART_Human1.36628022
68KLF4_18555785_Chip-Seq_ESCs_Mouse1.34456953
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33719167
70P300_19829295_ChIP-Seq_ESCs_Human1.32563592
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30242271
72KDM2B_26808549_Chip-Seq_REH_Human1.29665367
73RNF2_27304074_Chip-Seq_NSC_Mouse1.27910917
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27803753
75FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27332610
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.27140773
77TAF15_26573619_Chip-Seq_HEK293_Human1.26961550
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.26370326
79PU1_27457419_Chip-Seq_LIVER_Mouse1.25495549
80OCT4_21477851_ChIP-Seq_ESCs_Mouse1.24579700
81TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24377384
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23870871
83FOXA1_25329375_ChIP-Seq_VCAP_Human1.23870871
84CTCF_18555785_Chip-Seq_ESCs_Mouse1.23279142
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23219863
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.22143832
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21527700
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21350946
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21112049
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20832870
91TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20771134
92RUNX2_22187159_ChIP-Seq_PCA_Human1.20709163
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20489486
94CRX_20693478_ChIP-Seq_RETINA_Mouse1.20425244
95SMAD4_21799915_ChIP-Seq_A2780_Human1.18879273
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.18241789
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.17985787
98DROSHA_22980978_ChIP-Seq_HELA_Human1.17378971
99E2F1_21310950_ChIP-Seq_MCF-7_Human1.17360641
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16571517
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16266749
102TBL1_22424771_ChIP-Seq_293T_Human1.15803678
103NOTCH1_21737748_ChIP-Seq_TLL_Human1.15750883
104TP53_18474530_ChIP-ChIP_U2OS_Human1.15268417
105* ER_23166858_ChIP-Seq_MCF-7_Human1.14475043
106KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14054578
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13079673
108TCF4_22108803_ChIP-Seq_LS180_Human1.12281045
109TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.10981096
110TCF4_23295773_ChIP-Seq_U87_Human1.10682399
111YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08428995
112SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06793839
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.05889623
114SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05545918
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05530910
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05228669
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.03298384
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02321126
119NCOR_22424771_ChIP-Seq_293T_Human1.02143469
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01605878
121AR_25329375_ChIP-Seq_VCAP_Human1.01590289
122ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01455257
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00282864
124RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99345608
125CJUN_26792858_Chip-Seq_BT549_Human0.98452952
126* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98229103
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96480214
128ETV1_20927104_ChIP-Seq_GIST48_Human0.96472687
129REST_21632747_ChIP-Seq_MESCs_Mouse0.96096845
130AHR_22903824_ChIP-Seq_MCF-7_Human0.95398504
131RXR_22108803_ChIP-Seq_LS180_Human0.95133967
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94337743
133TP53_16413492_ChIP-PET_HCT116_Human0.93662298
134CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93483489
135Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91907900
136PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91854535
137TCF4_18268006_ChIP-ChIP_LS174T_Human0.91524377
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89336791
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89108828
140CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87574951
141NFYA_21822215_ChIP-Seq_K562_Human0.87074038
142STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.86396947
143CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85359731
144NFYB_21822215_ChIP-Seq_K562_Human0.85268710
145* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84431892
146HNFA_21074721_ChIP-Seq_CACO-2_Human0.81588242

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003252_abnormal_bile_duct7.09477381
2MP0003011_delayed_dark_adaptation5.91598221
3MP0002736_abnormal_nociception_after4.40802004
4MP0008057_abnormal_DNA_replication3.58140466
5MP0006292_abnormal_olfactory_placode3.42371629
6MP0001968_abnormal_touch/_nociception3.32044335
7MP0003693_abnormal_embryo_hatching3.29080707
8MP0003111_abnormal_nucleus_morphology3.22949624
9MP0000371_diluted_coat_color3.16994455
10MP0000569_abnormal_digit_pigmentation3.12573892
11MP0008877_abnormal_DNA_methylation2.97725996
12MP0010094_abnormal_chromosome_stability2.96832036
13MP0008058_abnormal_DNA_repair2.90970869
14MP0008007_abnormal_cellular_replicative2.84199500
15MP0003787_abnormal_imprinting2.64499432
16MP0002396_abnormal_hematopoietic_system2.61246193
17MP0002163_abnormal_gland_morphology2.58958515
18MP0005451_abnormal_body_composition2.57501774
19MP0003077_abnormal_cell_cycle2.57301848
20MP0002102_abnormal_ear_morphology2.55265576
21MP0008260_abnormal_autophagy2.35621109
22MP0005253_abnormal_eye_physiology2.31655621
23MP0002837_dystrophic_cardiac_calcinosis2.29517293
24MP0003195_calcinosis2.23666823
25MP0010307_abnormal_tumor_latency2.23010205
26MP0001188_hyperpigmentation2.19372252
27MP0009745_abnormal_behavioral_response2.14845115
28MP0001986_abnormal_taste_sensitivity2.07061156
29MP0006072_abnormal_retinal_apoptosis2.06442139
30MP0000566_synostosis2.03281812
31MP0003950_abnormal_plasma_membrane2.00773609
32MP0001501_abnormal_sleep_pattern1.90818664
33MP0003718_maternal_effect1.89562548
34MP0005310_abnormal_salivary_gland1.78476417
35MP0000427_abnormal_hair_cycle1.72990595
36MP0002009_preneoplasia1.72379284
37MP0003186_abnormal_redox_activity1.71871067
38MP0004885_abnormal_endolymph1.71431254
39MP0009046_muscle_twitch1.69927731
40MP0005551_abnormal_eye_electrophysiolog1.68738924
41MP0004130_abnormal_muscle_cell1.68530313
42MP0005646_abnormal_pituitary_gland1.64230161
43MP0005379_endocrine/exocrine_gland_phen1.57634027
44MP0009384_cardiac_valve_regurgitation1.57540251
45MP0006035_abnormal_mitochondrial_morpho1.55295377
46MP0002277_abnormal_respiratory_mucosa1.54778578
47MP0000015_abnormal_ear_pigmentation1.52166386
48MP0004808_abnormal_hematopoietic_stem1.51098001
49MP0005397_hematopoietic_system_phenotyp1.49253076
50MP0001545_abnormal_hematopoietic_system1.49253076
51MP0003136_yellow_coat_color1.48940954
52MP0009697_abnormal_copulation1.48648763
53MP0002210_abnormal_sex_determination1.46928445
54MP0003646_muscle_fatigue1.46208477
55MP0005334_abnormal_fat_pad1.46133251
56MP0003137_abnormal_impulse_conducting1.44797678
57MP0001346_abnormal_lacrimal_gland1.42963894
58MP0001666_abnormal_nutrient_absorption1.40664127
59MP0003121_genomic_imprinting1.39598275
60MP0001119_abnormal_female_reproductive1.38950020
61MP0005075_abnormal_melanosome_morpholog1.38075462
62MP0002234_abnormal_pharynx_morphology1.35243690
63MP0005171_absent_coat_pigmentation1.32153028
64MP0001929_abnormal_gametogenesis1.31938114
65MP0003937_abnormal_limbs/digits/tail_de1.31005581
66MP0004147_increased_porphyrin_level1.27310671
67MP0003172_abnormal_lysosome_physiology1.23981867
68MP0002075_abnormal_coat/hair_pigmentati1.23165306
69MP0003828_pulmonary_edema1.23084046
70MP0008995_early_reproductive_senescence1.22787595
71MP0005423_abnormal_somatic_nervous1.20170788
72MP0003119_abnormal_digestive_system1.19176628
73MP0002282_abnormal_trachea_morphology1.14523926
74MP0002272_abnormal_nervous_system1.14410225
75MP0005671_abnormal_response_to1.13363647
76MP0000653_abnormal_sex_gland1.12500570
77MP0003123_paternal_imprinting1.12351402
78MP0004043_abnormal_pH_regulation1.09441071
79MP0005410_abnormal_fertilization1.09107687
80MP0005083_abnormal_biliary_tract1.08816689
81MP0000383_abnormal_hair_follicle1.07782705
82MP0009333_abnormal_splenocyte_physiolog1.06266767
83MP0000350_abnormal_cell_proliferation1.05165787
84MP0002064_seizures1.04442692
85MP0001145_abnormal_male_reproductive1.04382447
86MP0001529_abnormal_vocalization1.03363003
87MP0003699_abnormal_female_reproductive1.03034480
88MP0003786_premature_aging1.02739944
89MP0004742_abnormal_vestibular_system1.02543050
90MP0005647_abnormal_sex_gland1.02326878
91MP0003938_abnormal_ear_development1.01866633
92MP0001764_abnormal_homeostasis1.01227324
93MP0002006_tumorigenesis1.00910458
94MP0001672_abnormal_embryogenesis/_devel1.00157394
95MP0005380_embryogenesis_phenotype1.00157394
96MP0004264_abnormal_extraembryonic_tissu0.99936118
97MP0004924_abnormal_behavior0.99767323
98MP0005386_behavior/neurological_phenoty0.99767323
99MP0002876_abnormal_thyroid_physiology0.99487507
100MP0002938_white_spotting0.96642365
101MP0010386_abnormal_urinary_bladder0.96560917
102MP0002693_abnormal_pancreas_physiology0.96220575
103MP0002638_abnormal_pupillary_reflex0.94523967
104MP0003763_abnormal_thymus_physiology0.93794414
105MP0004957_abnormal_blastocyst_morpholog0.91886268
106MP0003698_abnormal_male_reproductive0.90043017
107MP0002132_abnormal_respiratory_system0.89675037
108MP0002095_abnormal_skin_pigmentation0.89255897
109MP0003890_abnormal_embryonic-extraembry0.88379688
110MP0000428_abnormal_craniofacial_morphol0.87198486
111MP0002160_abnormal_reproductive_system0.85815140
112MP0001835_abnormal_antigen_presentation0.85626807
113MP0002138_abnormal_hepatobiliary_system0.85449885
114MP0003943_abnormal_hepatobiliary_system0.85059888
115MP0005408_hypopigmentation0.84668524
116MP0002118_abnormal_lipid_homeostasis0.84260402
117MP0001485_abnormal_pinna_reflex0.83543515
118MP0005636_abnormal_mineral_homeostasis0.83498071
119MP0008961_abnormal_basal_metabolism0.82940563
120MP0005085_abnormal_gallbladder_physiolo0.82739635
121MP0005174_abnormal_tail_pigmentation0.82730588
122MP0005391_vision/eye_phenotype0.82390626
123MP0002166_altered_tumor_susceptibility0.81669875
124MP0000579_abnormal_nail_morphology0.81492919
125MP0003984_embryonic_growth_retardation0.79835294
126MP0006036_abnormal_mitochondrial_physio0.79106224
127MP0000631_abnormal_neuroendocrine_gland0.78347340
128MP0002398_abnormal_bone_marrow0.77904001
129MP0000749_muscle_degeneration0.77548283
130MP0002733_abnormal_thermal_nociception0.75824901
131MP0010678_abnormal_skin_adnexa0.75819492
132MP0002928_abnormal_bile_duct0.75701742
133MP0001324_abnormal_eye_pigmentation0.75200084
134MP0002088_abnormal_embryonic_growth/wei0.75024102
135MP0000627_abnormal_mammary_gland0.75010019
136MP0000490_abnormal_crypts_of0.74272068
137MP0001944_abnormal_pancreas_morphology0.73319220
138MP0002067_abnormal_sensory_capabilities0.72675389
139MP0005621_abnormal_cell_physiology0.72424816
140MP0001486_abnormal_startle_reflex0.72260819
141MP0000432_abnormal_head_morphology0.71851913
142MP0009278_abnormal_bone_marrow0.70161973
143MP0005395_other_phenotype0.70035791
144MP0001186_pigmentation_phenotype0.69979464
145MP0009703_decreased_birth_body0.69837734
146MP0005409_darkened_coat_color0.69086371
147MP0002177_abnormal_outer_ear0.69072581
148MP0005389_reproductive_system_phenotype0.67343678
149MP0002751_abnormal_autonomic_nervous0.66725105
150MP0003941_abnormal_skin_development0.66071419
151MP0000372_irregular_coat_pigmentation0.65198029
152MP0008770_decreased_survivor_rate0.65187611
153MP0005257_abnormal_intraocular_pressure0.64832595
154MP0001661_extended_life_span0.64235517
155MP0003755_abnormal_palate_morphology0.63156214
156MP0004145_abnormal_muscle_electrophysio0.61975648
157MP0004381_abnormal_hair_follicle0.61968374
158MP0001800_abnormal_humoral_immune0.61703705
159MP0000313_abnormal_cell_death0.61273198
160MP0002161_abnormal_fertility/fecundity0.59791481
161MP0003936_abnormal_reproductive_system0.59545703
162MP0009250_abnormal_appendicular_skeleto0.59520854
163MP0005084_abnormal_gallbladder_morpholo0.58935984
164* MP0002085_abnormal_embryonic_tissue0.57637276
165MP0004215_abnormal_myocardial_fiber0.56794930
166MP0008932_abnormal_embryonic_tissue0.56753514
167MP0005330_cardiomyopathy0.53124823
168MP0001963_abnormal_hearing_physiology0.52133332

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)9.65002373
2Progressive cerebellar ataxia (HP:0002073)8.27050109
3Chromosomal breakage induced by crosslinking agents (HP:0003221)6.33879855
4Gaze-evoked nystagmus (HP:0000640)5.97791765
5Chromsome breakage (HP:0040012)5.89711220
6Absence seizures (HP:0002121)5.89563284
7Pendular nystagmus (HP:0012043)5.69338300
8Urinary bladder sphincter dysfunction (HP:0002839)5.48422171
9Slow saccadic eye movements (HP:0000514)5.47877175
10Prostate neoplasm (HP:0100787)4.95173468
11Postural instability (HP:0002172)4.94886331
12Postural tremor (HP:0002174)4.90607046
13Dysdiadochokinesis (HP:0002075)4.77977435
14Dialeptic seizures (HP:0011146)4.61870446
15Impaired vibratory sensation (HP:0002495)4.59316668
16Hypochromic microcytic anemia (HP:0004840)4.44265119
17Focal seizures (HP:0007359)4.37623880
18Limb ataxia (HP:0002070)4.10842929
19Birth length less than 3rd percentile (HP:0003561)3.99037199
20Severe visual impairment (HP:0001141)3.87236099
21Impaired smooth pursuit (HP:0007772)3.86995957
22Impaired proprioception (HP:0010831)3.56459578
23Abnormality of the fingertips (HP:0001211)3.55941948
24Aplasia/Hypoplasia of the uvula (HP:0010293)3.53348036
25Abnormality of macular pigmentation (HP:0008002)3.53338244
26Abnormality of the preputium (HP:0100587)3.49873001
27Abnormality of chromosome stability (HP:0003220)3.47130234
28Meckel diverticulum (HP:0002245)3.42378299
29Capillary hemangiomas (HP:0005306)3.36373151
30Hyperventilation (HP:0002883)3.35205793
31Acute myeloid leukemia (HP:0004808)3.21401302
32Abnormality of the ileum (HP:0001549)3.20555204
33Ectopic kidney (HP:0000086)3.03159030
34Facial hemangioma (HP:0000329)2.99481936
35Postnatal microcephaly (HP:0005484)2.93052188
36Papillary thyroid carcinoma (HP:0002895)2.92090905
37Clubbing of toes (HP:0100760)2.90633251
38Rib fusion (HP:0000902)2.89861242
39Impulsivity (HP:0100710)2.89683897
40Pancreatic fibrosis (HP:0100732)2.80837938
41Myelodysplasia (HP:0002863)2.79718514
42Abnormality of the prostate (HP:0008775)2.74286358
43Bilateral microphthalmos (HP:0007633)2.71816102
44Abnormality of ocular smooth pursuit (HP:0000617)2.71201225
45Areflexia of lower limbs (HP:0002522)2.62135554
46Abnormal spermatogenesis (HP:0008669)2.54939019
47Oculomotor apraxia (HP:0000657)2.54459277
48Chorioretinal atrophy (HP:0000533)2.53226911
49Abnormality of vision evoked potentials (HP:0000649)2.52573490
50Patellar aplasia (HP:0006443)2.51920308
51Azoospermia (HP:0000027)2.50200728
52Atonic seizures (HP:0010819)2.48722081
53Increased corneal curvature (HP:0100692)2.46993183
54Keratoconus (HP:0000563)2.46993183
55Biliary tract neoplasm (HP:0100574)2.45702580
56Duodenal stenosis (HP:0100867)2.43945063
57Small intestinal stenosis (HP:0012848)2.43945063
58Oligodactyly (hands) (HP:0001180)2.42073933
59Vitreoretinal degeneration (HP:0000655)2.37990212
60Abnormality of the carotid arteries (HP:0005344)2.36239928
61Hypochromic anemia (HP:0001931)2.35295649
62Abnormality of the columella (HP:0009929)2.34993613
63Lip pit (HP:0100267)2.33950351
64Hypoplasia of the capital femoral epiphysis (HP:0003090)2.33466100
65Abnormality of the labia minora (HP:0012880)2.33081467
66Aplasia/Hypoplasia of the patella (HP:0006498)2.32917728
67Febrile seizures (HP:0002373)2.28454674
68Acute lymphatic leukemia (HP:0006721)2.28116902
69Fibular aplasia (HP:0002990)2.27457530
70Nephroblastoma (Wilms tumor) (HP:0002667)2.25441217
71Abnormality of male internal genitalia (HP:0000022)2.25335466
72Protruding tongue (HP:0010808)2.23339835
73Abnormality of saccadic eye movements (HP:0000570)2.21004942
74Abnormal hair whorl (HP:0010721)2.20560018
75Severe Myopia (HP:0011003)2.20349806
76Absent/shortened dynein arms (HP:0200106)2.17903381
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.17903381
78Volvulus (HP:0002580)2.17002161
79Pancreatic cysts (HP:0001737)2.16608899
80Decreased muscle mass (HP:0003199)2.14926466
81Proximal tubulopathy (HP:0000114)2.13751583
82Flat capital femoral epiphysis (HP:0003370)2.13545343
83Abnormality of DNA repair (HP:0003254)2.10929263
84Breast hypoplasia (HP:0003187)2.10749541
85Retinitis pigmentosa (HP:0000510)2.09676710
86Abnormal respiratory motile cilium physiology (HP:0012261)2.09433980
87Embryonal renal neoplasm (HP:0011794)2.08200933
88Bone marrow hypocellularity (HP:0005528)2.07648458
89Aplasia/Hypoplasia of the tibia (HP:0005772)2.06155691
90Clumsiness (HP:0002312)2.04073705
91Tinnitus (HP:0000360)2.01553534
92Fair hair (HP:0002286)2.00312207
93Genetic anticipation (HP:0003743)11.2373490
94Dysmetric saccades (HP:0000641)10.0637832
95Abnormality of the renal collecting system (HP:0004742)1.96158560
96Sloping forehead (HP:0000340)1.95373516
97Abolished electroretinogram (ERG) (HP:0000550)1.95155939
98Portal hypertension (HP:0001409)1.94523232
99Thyroid carcinoma (HP:0002890)1.93655250
100Anal stenosis (HP:0002025)1.91317409
101Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89873538
102Prominent nose (HP:0000448)1.89363138
103Short thumb (HP:0009778)1.89069275
104Short tibia (HP:0005736)1.88872074
105Bradykinesia (HP:0002067)1.87079446
106Anomalous pulmonary venous return (HP:0010772)1.87069742
107Absent epiphyses (HP:0010577)1.86487207
108Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86487207
109Oligodactyly (HP:0012165)1.86482154
110Asymmetry of the thorax (HP:0001555)1.86367463
111Syringomyelia (HP:0003396)1.85784498
112Spinal cord lesions (HP:0100561)1.85784498
113Abnormal ciliary motility (HP:0012262)1.85732212
114Duplicated collecting system (HP:0000081)1.85411940
115Adrenal hypoplasia (HP:0000835)1.84470991
116Abnormality of the duodenum (HP:0002246)1.84014119
117Neoplasm of the adrenal cortex (HP:0100641)1.82929223
118Breast aplasia (HP:0100783)1.82053335
119Long eyelashes (HP:0000527)1.81743396
120* Abnormality of the hepatic vasculature (HP:0006707)1.81390177
121Generalized hypopigmentation of hair (HP:0011358)1.80903234
122Microglossia (HP:0000171)1.80702091
123Retrobulbar optic neuritis (HP:0100654)1.80165137
124Optic neuritis (HP:0100653)1.80165137
125Nephronophthisis (HP:0000090)1.80118165
126Hypoproteinemia (HP:0003075)1.77455941
127Microtia (HP:0008551)1.77397880
128True hermaphroditism (HP:0010459)1.77053165
129Inability to walk (HP:0002540)1.75766014
130Absent radius (HP:0003974)1.75672591
131Poor coordination (HP:0002370)1.74805088
132Abnormal biliary tract morphology (HP:0012440)1.74170204
133Arteriovenous malformation (HP:0100026)1.73251438
134Shawl scrotum (HP:0000049)1.71545625
135Abnormality of incisor morphology (HP:0011063)1.70868194
136Abnormality of the femoral head (HP:0003368)1.70255899
137Aplasia/Hypoplasia of the macula (HP:0008059)1.69743734
138Hemiparesis (HP:0001269)1.69302209
139Absent speech (HP:0001344)1.69296323
140Abnormality of chromosome segregation (HP:0002916)1.69191505
141Thyroiditis (HP:0100646)1.69046696
142Astigmatism (HP:0000483)1.68797502
143Gingival bleeding (HP:0000225)1.68080663
144Broad-based gait (HP:0002136)1.67937732
145Anal atresia (HP:0002023)1.67841254
146Aplasia/Hypoplasia affecting the retina (HP:0008061)1.67812228
147Septo-optic dysplasia (HP:0100842)1.67780607
148Abnormality of the epiphysis of the femoral head (HP:0010574)1.66970977
149Molar tooth sign on MRI (HP:0002419)1.66776700
150Abnormality of midbrain morphology (HP:0002418)1.66776700
151Hypoplasia of the fovea (HP:0007750)1.66291536
152Aplasia/Hypoplasia of the fovea (HP:0008060)1.66291536
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.66088539
154Tubular atrophy (HP:0000092)1.65670655
155Triphalangeal thumb (HP:0001199)1.65076975
156Absent forearm bone (HP:0003953)1.64582697
157Aplasia involving forearm bones (HP:0009822)1.64582697
158Abnormality of the phalanges of the hallux (HP:0010057)1.63929471
159Submucous cleft hard palate (HP:0000176)1.63357224
160Aplasia/Hypoplasia of the breasts (HP:0010311)1.62697926
161Focal motor seizures (HP:0011153)1.62479820
162Cafe-au-lait spot (HP:0000957)1.61929757
163Postaxial foot polydactyly (HP:0001830)1.60780068
164Chronic hepatic failure (HP:0100626)1.60447305
165Cystic hygroma (HP:0000476)1.59548133
166Hypophosphatemic rickets (HP:0004912)1.58905696
167Abnormality of the pulmonary veins (HP:0011718)1.57987570
168Abnormality of the renal cortex (HP:0011035)1.56626795
169Congenital stationary night blindness (HP:0007642)1.54314456
170Hyperthyroidism (HP:0000836)1.54191220
171Hypobetalipoproteinemia (HP:0003563)1.52062631
172Abnormal biliary tract physiology (HP:0012439)1.51967172
173Bile duct proliferation (HP:0001408)1.51967172
174Congenital sensorineural hearing impairment (HP:0008527)1.50560091
175Hemiplegia (HP:0002301)1.47732140
176Fasciculations (HP:0002380)1.47578863
177Abnormality of the renal medulla (HP:0100957)1.45357760
178Hypoplastic iliac wings (HP:0002866)1.45265418
179Macroglossia (HP:0000158)1.43577977
180Scrotal hypoplasia (HP:0000046)1.41440214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OXSR16.00697009
2LATS13.73857147
3STK38L3.13396402
4MAP3K72.60928890
5SRPK12.58533503
6MKNK22.49641722
7LATS22.48242460
8CDC72.41799398
9PLK42.28697249
10AKT32.16338064
11STK32.14090577
12TNK22.08332760
13CDK1910.7785218
14CDK31.98739606
15SGK21.95688986
16NEK21.90989942
17ZAK1.85972446
18TNIK1.84860022
19PRPF4B1.70673693
20BRSK21.70240100
21MAP3K141.66932358
22CDK81.65264738
23BRD41.52142118
24CASK1.52026605
25CCNB11.49700770
26NUAK11.48434528
27RPS6KB21.46752846
28NEK61.43342257
29FRK1.41666546
30EIF2AK21.41382281
31ACVR1B1.40223303
32CHEK21.39722804
33TXK1.36116136
34CDK121.34724615
35MKNK11.33061248
36TTK1.31318420
37MUSK1.26041573
38TAOK31.25731328
39MAP3K61.24178803
40PLK31.18922812
41MAP2K71.18644967
42ALK1.17338846
43PLK11.16769910
44DYRK31.16769738
45SGK31.14452318
46ERBB41.13372938
47IRAK31.10914433
48TGFBR11.10152726
49JAK31.08695322
50INSRR1.07893566
51ATR1.07466449
52FER1.06485998
53CAMK1D1.04940818
54STK381.01237229
55SGK2231.00732556
56SGK4941.00732556
57MARK31.00567998
58MAPK130.97000299
59STK110.95064945
60AURKB0.94665252
61DYRK20.92529525
62ATM0.91675448
63YES10.89246884
64VRK10.88404100
65EPHA30.83750017
66BUB10.83526422
67CHEK10.82058005
68WNK30.80565386
69WNK40.79103486
70RAF10.79074530
71CDK90.77480380
72CHUK0.75757112
73RIPK40.75545902
74NLK0.74201095
75WEE10.71231417
76TEC0.71175092
77DYRK1A0.70209358
78MAP3K130.69928133
79FGFR30.68082058
80CDK70.67655691
81PRKAA20.66415686
82IKBKB0.66016622
83BMPR1B0.66007295
84PRKAA10.65397331
85STK240.65142039
86TAF10.64228252
87MELK0.64104300
88BRSK10.63527345
89BRAF0.61670847
90PAK60.59626058
91BCR0.58498491
92STK40.57306515
93ADRBK20.56968784
94PIM10.56955702
95JAK10.56167815
96PINK10.56109431
97GRK10.56079228
98MAP3K40.55851302
99CDK10.53896682
100KSR10.53475237
101SIK30.53433688
102MAPK100.53130952
103EIF2AK30.52842085
104CDK20.52175591
105KIT0.51148233
106SGK10.50534384
107IKBKE0.48140788
108JAK20.47901211
109CDK40.47827993
110MAP4K20.47560875
111NTRK30.47414942
112MAPKAPK50.46340972
113ERBB20.46108835
114RPS6KA40.44901725
115BMPR20.44023418
116CAMK1G0.43694134
117ADRBK10.42583916
118TIE10.39880518
119ERBB30.39767627
120CAMKK20.38419445
121OBSCN0.36868821
122PDK10.32068060
123PDPK10.30047297
124CSNK1A1L0.27520043
125PRKCG0.26991973
126PRKG10.26912927
127CSNK1G10.25903445
128PBK0.25485562
129STK390.24563288
130PKN10.24461474
131CSNK1G20.24330722
132CDK150.23758678
133CDK180.23220511
134MAP2K10.21272238
135MTOR0.21017464
136RPS6KB10.20964758
137CSNK1G30.20535926
138CDK50.19240665
139PLK20.18778968
140PTK2B0.18704602
141DAPK20.18154819
142TRPM70.17206114
143PIK3CA0.16834449
144CDK11A0.16723567
145CSNK1A10.16347335
146CSNK1D0.15965478
147PASK0.15850685
148PRKCE0.14838597
149ABL10.14348065
150CAMK2A0.13323673
151SIK20.13027702
152PIK3CG0.12981548
153FGFR20.12885602
154NEK10.12864182

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001208.17175263
2Vitamin B6 metabolism_Homo sapiens_hsa007504.12831987
3Fanconi anemia pathway_Homo sapiens_hsa034602.89684249
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.81712100
5RNA polymerase_Homo sapiens_hsa030202.70960921
6Basal transcription factors_Homo sapiens_hsa030222.69923241
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.63021560
8Cell cycle_Homo sapiens_hsa041102.62059472
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.60718640
10Fatty acid biosynthesis_Homo sapiens_hsa000612.43049635
11Caffeine metabolism_Homo sapiens_hsa002322.41038692
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.28459585
13Homologous recombination_Homo sapiens_hsa034402.15006548
14Retinol metabolism_Homo sapiens_hsa008302.14978898
15Butanoate metabolism_Homo sapiens_hsa006502.10119699
16Tryptophan metabolism_Homo sapiens_hsa003802.09860019
17Propanoate metabolism_Homo sapiens_hsa006402.09736789
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06407522
19Olfactory transduction_Homo sapiens_hsa047402.06017017
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79733510
21RNA degradation_Homo sapiens_hsa030181.73365674
22p53 signaling pathway_Homo sapiens_hsa041151.70456718
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.69927068
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67659675
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65852850
26Circadian rhythm_Homo sapiens_hsa047101.65355809
27Herpes simplex infection_Homo sapiens_hsa051681.62594841
28Linoleic acid metabolism_Homo sapiens_hsa005911.51344270
29mRNA surveillance pathway_Homo sapiens_hsa030151.50418544
30RNA transport_Homo sapiens_hsa030131.46863293
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.46701755
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.40362913
33Regulation of autophagy_Homo sapiens_hsa041401.38749775
34Non-homologous end-joining_Homo sapiens_hsa034501.37211012
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34562768
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.32720376
37Allograft rejection_Homo sapiens_hsa053301.25025269
38Autoimmune thyroid disease_Homo sapiens_hsa053201.24334539
39Measles_Homo sapiens_hsa051621.24261705
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17889252
41Vitamin digestion and absorption_Homo sapiens_hsa049771.14671067
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12995646
43Influenza A_Homo sapiens_hsa051641.09130324
44Inositol phosphate metabolism_Homo sapiens_hsa005621.08869063
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05829821
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05012042
47Graft-versus-host disease_Homo sapiens_hsa053321.04684772
48Nicotine addiction_Homo sapiens_hsa050331.03721573
49MicroRNAs in cancer_Homo sapiens_hsa052061.03546402
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02603082
51Jak-STAT signaling pathway_Homo sapiens_hsa046301.01272292
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.00444163
53Purine metabolism_Homo sapiens_hsa002301.00250546
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99085795
55Primary immunodeficiency_Homo sapiens_hsa053400.98803883
56Phototransduction_Homo sapiens_hsa047440.97578398
57Sphingolipid metabolism_Homo sapiens_hsa006000.96620644
58Chemical carcinogenesis_Homo sapiens_hsa052040.94734583
59Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94240734
60Base excision repair_Homo sapiens_hsa034100.93886022
61Nucleotide excision repair_Homo sapiens_hsa034200.93739954
62Hepatitis B_Homo sapiens_hsa051610.91623820
63Pyrimidine metabolism_Homo sapiens_hsa002400.90578207
64ABC transporters_Homo sapiens_hsa020100.90233368
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88457043
66FoxO signaling pathway_Homo sapiens_hsa040680.87239350
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85956056
68PPAR signaling pathway_Homo sapiens_hsa033200.85400949
69Choline metabolism in cancer_Homo sapiens_hsa052310.84155000
70Prostate cancer_Homo sapiens_hsa052150.83029535
71Spliceosome_Homo sapiens_hsa030400.82360022
72Oocyte meiosis_Homo sapiens_hsa041140.82186179
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.82055345
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81236602
75Mismatch repair_Homo sapiens_hsa034300.80280331
76Rheumatoid arthritis_Homo sapiens_hsa053230.79782632
77TGF-beta signaling pathway_Homo sapiens_hsa043500.79686327
78Prolactin signaling pathway_Homo sapiens_hsa049170.79673304
79Epstein-Barr virus infection_Homo sapiens_hsa051690.79135066
80Pancreatic cancer_Homo sapiens_hsa052120.79025728
81Salivary secretion_Homo sapiens_hsa049700.79018787
82TNF signaling pathway_Homo sapiens_hsa046680.78302179
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77109795
84Fatty acid degradation_Homo sapiens_hsa000710.76219879
85Small cell lung cancer_Homo sapiens_hsa052220.75904019
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75374300
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.75045332
88Nitrogen metabolism_Homo sapiens_hsa009100.74639231
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74593695
90Renin-angiotensin system_Homo sapiens_hsa046140.73627878
91Hematopoietic cell lineage_Homo sapiens_hsa046400.73012123
92Gastric acid secretion_Homo sapiens_hsa049710.71623103
93Taste transduction_Homo sapiens_hsa047420.71055123
94N-Glycan biosynthesis_Homo sapiens_hsa005100.70707677
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67150269
96Chemokine signaling pathway_Homo sapiens_hsa040620.64843831
97Ovarian steroidogenesis_Homo sapiens_hsa049130.63563329
98Type I diabetes mellitus_Homo sapiens_hsa049400.62170946
99Ether lipid metabolism_Homo sapiens_hsa005650.61844376
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61783544
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57993341
102Starch and sucrose metabolism_Homo sapiens_hsa005000.57574676
103Lysine degradation_Homo sapiens_hsa003100.57236001
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57179709
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56512217
106ErbB signaling pathway_Homo sapiens_hsa040120.55007772
107Fatty acid metabolism_Homo sapiens_hsa012120.54651900
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54583380
109DNA replication_Homo sapiens_hsa030300.53763070
110beta-Alanine metabolism_Homo sapiens_hsa004100.53755387
111MAPK signaling pathway_Homo sapiens_hsa040100.52826934
112Endometrial cancer_Homo sapiens_hsa052130.51530704
113Pyruvate metabolism_Homo sapiens_hsa006200.50193715
114Melanoma_Homo sapiens_hsa052180.49943091
115Long-term depression_Homo sapiens_hsa047300.48617550
116cAMP signaling pathway_Homo sapiens_hsa040240.47699239
117T cell receptor signaling pathway_Homo sapiens_hsa046600.46883497
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46685688
119Peroxisome_Homo sapiens_hsa041460.46401210
120Glutamatergic synapse_Homo sapiens_hsa047240.46016254
121Viral carcinogenesis_Homo sapiens_hsa052030.45883953
122Glycerolipid metabolism_Homo sapiens_hsa005610.45723551
123HTLV-I infection_Homo sapiens_hsa051660.44946459
124Hedgehog signaling pathway_Homo sapiens_hsa043400.44597275
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44322945
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43888771
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42765754
128Serotonergic synapse_Homo sapiens_hsa047260.42753587
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41219161
130Wnt signaling pathway_Homo sapiens_hsa043100.41195654
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.41155347
132Osteoclast differentiation_Homo sapiens_hsa043800.40911491
133Ras signaling pathway_Homo sapiens_hsa040140.40904831
134Hepatitis C_Homo sapiens_hsa051600.40799715
135Dorso-ventral axis formation_Homo sapiens_hsa043200.40455521
136Type II diabetes mellitus_Homo sapiens_hsa049300.40137226
137Apoptosis_Homo sapiens_hsa042100.39191131
138B cell receptor signaling pathway_Homo sapiens_hsa046620.39039852
139Metabolic pathways_Homo sapiens_hsa011000.38720687
140Thyroid cancer_Homo sapiens_hsa052160.38368743
141Asthma_Homo sapiens_hsa053100.38243434
142Colorectal cancer_Homo sapiens_hsa052100.37917430
143Tuberculosis_Homo sapiens_hsa051520.37868430
144Morphine addiction_Homo sapiens_hsa050320.36931849
145Pentose phosphate pathway_Homo sapiens_hsa000300.36207101
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.36127052
147Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35620101
148Calcium signaling pathway_Homo sapiens_hsa040200.34055600
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32252462
150Insulin resistance_Homo sapiens_hsa049310.29052197
151Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28959362
152Insulin secretion_Homo sapiens_hsa049110.28720255
153Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27266245
154Selenocompound metabolism_Homo sapiens_hsa004500.25896560
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.24652520
156Basal cell carcinoma_Homo sapiens_hsa052170.22632200
157Circadian entrainment_Homo sapiens_hsa047130.21912544
158Arachidonic acid metabolism_Homo sapiens_hsa005900.21904352
159Axon guidance_Homo sapiens_hsa043600.21757468
160Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21207720
161cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19745341
162Pancreatic secretion_Homo sapiens_hsa049720.19123442
163Renin secretion_Homo sapiens_hsa049240.19045603

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