KRR1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)7.33438299
2cellular response to electrical stimulus (GO:0071257)6.36806115
3negative regulation of calcium ion transport into cytosol (GO:0010523)6.33595226
4protein maturation by protein folding (GO:0022417)5.75711927
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52751781
6protein localization to cilium (GO:0061512)5.34674587
7negative regulation of heart rate (GO:0010459)5.31892734
8regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.29301871
9postsynaptic membrane organization (GO:0001941)5.28094255
10negative regulation of phosphoprotein phosphatase activity (GO:0032515)5.22359276
11behavioral response to ethanol (GO:0048149)5.20703047
12positive regulation of sodium ion transmembrane transporter activity (GO:2000651)5.13833234
13protein export from nucleus (GO:0006611)5.12207344
14inactivation of MAPK activity (GO:0000188)5.03388255
15positive regulation of action potential (GO:0045760)4.95342553
16positive regulation of vesicle fusion (GO:0031340)4.91535319
17sarcoplasmic reticulum calcium ion transport (GO:0070296)4.68797624
18negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.67603067
19positive regulation of sodium ion transmembrane transport (GO:1902307)4.49915089
20negative regulation of sequestering of calcium ion (GO:0051283)4.43118666
21release of sequestered calcium ion into cytosol (GO:0051209)4.43118666
22regulation of axon regeneration (GO:0048679)4.42228674
23regulation of neuron projection regeneration (GO:0070570)4.42228674
24collecting duct development (GO:0072044)4.27105404
25regulation of beta-amyloid formation (GO:1902003)4.23429605
26membrane depolarization during action potential (GO:0086010)4.22096239
27positive regulation of dendritic spine development (GO:0060999)4.16253700
28layer formation in cerebral cortex (GO:0021819)4.08005426
29positive regulation of cellular amide metabolic process (GO:0034250)4.03276571
30regulation of sequestering of calcium ion (GO:0051282)4.01534525
31regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.01456097
32response to redox state (GO:0051775)3.97787812
33positive regulation of microtubule polymerization (GO:0031116)3.85806587
34negative regulation of cation channel activity (GO:2001258)3.83300194
35labyrinthine layer development (GO:0060711)3.79063836
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.76380375
37maintenance of protein location in nucleus (GO:0051457)3.75626140
38sympathetic nervous system development (GO:0048485)3.75070764
39negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.74300508
40negative regulation of calcium ion transmembrane transport (GO:1903170)3.74300508
41regulation of penile erection (GO:0060405)3.72907659
42regulation of action potential (GO:0098900)3.72548566
43response to vitamin E (GO:0033197)3.67736415
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67609145
45neural tube formation (GO:0001841)3.67291220
46pattern specification involved in kidney development (GO:0061004)3.66683322
47cell-cell junction maintenance (GO:0045217)3.63613267
48behavioral defense response (GO:0002209)3.57545885
49behavioral fear response (GO:0001662)3.57545885
50regulation of glycogen (starch) synthase activity (GO:2000465)3.56517161
51calcium ion transport into cytosol (GO:0060402)3.54040581
52short-term memory (GO:0007614)3.52256058
53synaptic vesicle maturation (GO:0016188)3.50877969
54calcium-mediated signaling using intracellular calcium source (GO:0035584)3.50856834
55regulation of actin nucleation (GO:0051125)3.47917063
56smooth muscle contraction (GO:0006939)3.44941547
57negative regulation of adenylate cyclase activity (GO:0007194)3.43810956
58pyrimidine nucleobase catabolic process (GO:0006208)3.41550720
59cytosolic calcium ion transport (GO:0060401)3.40596357
60regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.37002520
61trivalent inorganic anion homeostasis (GO:0072506)3.36344722
62phosphate ion homeostasis (GO:0055062)3.36344722
63presynaptic membrane assembly (GO:0097105)3.32990526
64regulation of vesicle fusion (GO:0031338)3.32618787
65neuron cell-cell adhesion (GO:0007158)3.30725857
66cell junction maintenance (GO:0034331)3.30587407
67segment specification (GO:0007379)3.28908662
68positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.28568995
69protein polyglutamylation (GO:0018095)3.25621163
70Rac protein signal transduction (GO:0016601)3.24947141
71negative regulation of cyclase activity (GO:0031280)3.23584524
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.18657367
73regulation of translation, ncRNA-mediated (GO:0045974)3.18657367
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.18657367
75embryonic body morphogenesis (GO:0010172)3.14043753
76negative regulation of mast cell activation (GO:0033004)3.11467471
77neuron recognition (GO:0008038)3.11117640
78negative regulation of organelle assembly (GO:1902116)3.10725554
79positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09833439
80synapse assembly (GO:0007416)3.07938456
81synapsis (GO:0007129)3.07608834
82phenol-containing compound catabolic process (GO:0019336)3.06320351
83body morphogenesis (GO:0010171)3.05195873
84positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.02118579
85regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00659843
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.99480927
87behavioral response to nicotine (GO:0035095)2.97991904
88negative regulation of lyase activity (GO:0051350)2.96954372
89cellular anion homeostasis (GO:0030002)2.96522020
90fear response (GO:0042596)2.91582981
91response to lipoprotein particle (GO:0055094)2.91489171
92regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.90806161
93piRNA metabolic process (GO:0034587)2.90348491
94regulation of synaptic vesicle exocytosis (GO:2000300)2.89532390
95regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89008644
96negative regulation of cAMP biosynthetic process (GO:0030818)2.88909253
97retina layer formation (GO:0010842)2.88593965
98regulation of amyloid precursor protein catabolic process (GO:1902991)2.88513907
99positive regulation of filopodium assembly (GO:0051491)2.87431667
100negative regulation of appetite (GO:0032099)2.86291981

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74368466
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.40226407
3ZNF274_21170338_ChIP-Seq_K562_Hela3.34927422
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23496760
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.66214236
6FUS_26573619_Chip-Seq_HEK293_Human2.54954710
7TAF15_26573619_Chip-Seq_HEK293_Human2.51135311
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44842377
9CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39942450
10VDR_22108803_ChIP-Seq_LS180_Human2.37375756
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19545457
12IGF1R_20145208_ChIP-Seq_DFB_Human2.14146577
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05836181
14GBX2_23144817_ChIP-Seq_PC3_Human1.89670980
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.88835702
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.86766887
17REST_21632747_ChIP-Seq_MESCs_Mouse1.82131254
18GATA1_22025678_ChIP-Seq_K562_Human1.78838580
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75882894
20STAT3_23295773_ChIP-Seq_U87_Human1.74575544
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73936074
22TP53_16413492_ChIP-PET_HCT116_Human1.72935726
23WT1_19549856_ChIP-ChIP_CCG9911_Human1.71864457
24CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71340950
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68913253
26SMAD4_21799915_ChIP-Seq_A2780_Human1.68186730
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66597488
28RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.62093127
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57150009
30AR_25329375_ChIP-Seq_VCAP_Human1.56029856
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.55742431
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55697196
33REST_18959480_ChIP-ChIP_MESCs_Mouse1.52412017
34TCF4_23295773_ChIP-Seq_U87_Human1.52116037
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44003233
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43463316
37MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42987984
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.38754297
39RNF2_27304074_Chip-Seq_NSC_Mouse1.38222476
40CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.37403650
41BCAT_22108803_ChIP-Seq_LS180_Human1.35047301
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35024739
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.34259742
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34020277
45GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33911998
46FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.32790461
47IRF1_19129219_ChIP-ChIP_H3396_Human1.31722035
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31721987
49AR_21572438_ChIP-Seq_LNCaP_Human1.31540281
50JUN_21703547_ChIP-Seq_K562_Human1.31204181
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30018062
52TBL1_22424771_ChIP-Seq_293T_Human1.27893881
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.26181662
54TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25773009
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.25501371
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25318418
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22654081
58SMAD3_21741376_ChIP-Seq_ESCs_Human1.22648213
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.22356203
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19856039
61NFYA_21822215_ChIP-Seq_K562_Human1.19228744
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19038281
63TAL1_26923725_Chip-Seq_HPCs_Mouse1.18998334
64P300_19829295_ChIP-Seq_ESCs_Human1.18940116
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18321364
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.17989553
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17214381
68EWS_26573619_Chip-Seq_HEK293_Human1.15338056
69P53_22387025_ChIP-Seq_ESCs_Mouse1.15299534
70RARB_27405468_Chip-Seq_BRAIN_Mouse1.15161929
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14254065
72TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13423127
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.13402599
74TCF4_22108803_ChIP-Seq_LS180_Human1.12963213
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12647856
76CBP_20019798_ChIP-Seq_JUKART_Human1.12647856
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11592924
78ER_23166858_ChIP-Seq_MCF-7_Human1.11092165
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10056634
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.10048774
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09097045
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09097045
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.08170849
84RUNX2_22187159_ChIP-Seq_PCA_Human1.07016379
85EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06749099
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06340935
87DROSHA_22980978_ChIP-Seq_HELA_Human1.05596830
88FLI1_21867929_ChIP-Seq_TH2_Mouse1.04434659
89MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04291870
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02181079
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01066652
92OCT1_27270436_Chip-Seq_PROSTATE_Human1.00404728
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.00145222
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.99733015
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98926931
96P300_18555785_Chip-Seq_ESCs_Mouse0.97733825
97IRF8_21731497_ChIP-ChIP_J774_Mouse0.96486584
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96132549
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.96106970
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94639202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.28913480
2MP0003121_genomic_imprinting4.57477918
3MP0001984_abnormal_olfaction4.45528874
4MP0000569_abnormal_digit_pigmentation4.26809848
5MP0008877_abnormal_DNA_methylation3.99510827
6MP0003787_abnormal_imprinting3.97300920
7MP0004859_abnormal_synaptic_plasticity3.32168188
8MP0005423_abnormal_somatic_nervous3.12529583
9MP0002735_abnormal_chemical_nociception2.61364215
10MP0000778_abnormal_nervous_system2.47790766
11MP0002736_abnormal_nociception_after2.21654794
12MP0002102_abnormal_ear_morphology2.19865311
13MP0001968_abnormal_touch/_nociception2.14398703
14MP0001440_abnormal_grooming_behavior2.08369442
15MP0002734_abnormal_mechanical_nocicepti1.99567365
16MP0000383_abnormal_hair_follicle1.93055868
17MP0006276_abnormal_autonomic_nervous1.84784479
18MP0003635_abnormal_synaptic_transmissio1.83909779
19MP0000427_abnormal_hair_cycle1.79807793
20MP0009046_muscle_twitch1.71190968
21MP0003123_paternal_imprinting1.68540558
22MP0003890_abnormal_embryonic-extraembry1.64248574
23MP0006072_abnormal_retinal_apoptosis1.61759538
24MP0003646_muscle_fatigue1.61682198
25MP0002272_abnormal_nervous_system1.58155418
26MP0003172_abnormal_lysosome_physiology1.54220114
27MP0005394_taste/olfaction_phenotype1.52719863
28MP0005499_abnormal_olfactory_system1.52719863
29MP0005551_abnormal_eye_electrophysiolog1.49016289
30MP0002733_abnormal_thermal_nociception1.46588071
31MP0002184_abnormal_innervation1.46027603
32MP0001970_abnormal_pain_threshold1.43043012
33MP0002557_abnormal_social/conspecific_i1.41195158
34MP0002928_abnormal_bile_duct1.41138227
35MP0004742_abnormal_vestibular_system1.40497398
36MP0009745_abnormal_behavioral_response1.38771152
37MP0002572_abnormal_emotion/affect_behav1.38547678
38MP0002822_catalepsy1.34844689
39MP0002693_abnormal_pancreas_physiology1.33551739
40MP0001324_abnormal_eye_pigmentation1.33538783
41MP0003880_abnormal_central_pattern1.32598775
42MP0002063_abnormal_learning/memory/cond1.30961392
43MP0004142_abnormal_muscle_tone1.28238504
44MP0003950_abnormal_plasma_membrane1.28230008
45MP0004145_abnormal_muscle_electrophysio1.28023043
46MP0005386_behavior/neurological_phenoty1.26053148
47MP0004924_abnormal_behavior1.26053148
48MP0004134_abnormal_chest_morphology1.22573368
49MP0002064_seizures1.17774180
50MP0001348_abnormal_lacrimal_gland1.17234214
51MP0000516_abnormal_urinary_system1.14081357
52MP0005367_renal/urinary_system_phenotyp1.14081357
53MP0004133_heterotaxia1.11121761
54MP0001986_abnormal_taste_sensitivity1.09337589
55MP0008789_abnormal_olfactory_epithelium1.07857369
56MP0008875_abnormal_xenobiotic_pharmacok1.05708416
57MP0000579_abnormal_nail_morphology1.04402160
58MP0002332_abnormal_exercise_endurance1.02530477
59MP0002067_abnormal_sensory_capabilities1.01532738
60MP0000230_abnormal_systemic_arterial0.99750192
61MP0003045_fibrosis0.99552920
62MP0001919_abnormal_reproductive_system0.98392633
63MP0008004_abnormal_stomach_pH0.97786937
64MP0004811_abnormal_neuron_physiology0.97304816
65MP0005253_abnormal_eye_physiology0.95875191
66MP0000955_abnormal_spinal_cord0.94228722
67MP0003878_abnormal_ear_physiology0.90308836
68MP0005377_hearing/vestibular/ear_phenot0.90308836
69MP0008569_lethality_at_weaning0.90107021
70MP0001486_abnormal_startle_reflex0.88034850
71MP0000470_abnormal_stomach_morphology0.87586179
72MP0004085_abnormal_heartbeat0.85639047
73MP0004043_abnormal_pH_regulation0.85147139
74MP0010678_abnormal_skin_adnexa0.83648505
75MP0002882_abnormal_neuron_morphology0.83336330
76MP0002752_abnormal_somatic_nervous0.83003994
77MP0005195_abnormal_posterior_eye0.82478119
78MP0001501_abnormal_sleep_pattern0.80407313
79MP0009703_decreased_birth_body0.79332457
80MP0001485_abnormal_pinna_reflex0.79116470
81MP0004484_altered_response_of0.78491146
82MP0006035_abnormal_mitochondrial_morpho0.75998687
83MP0003633_abnormal_nervous_system0.75613271
84MP0002152_abnormal_brain_morphology0.74308271
85MP0003221_abnormal_cardiomyocyte_apopto0.72796096
86MP0001905_abnormal_dopamine_level0.72534087
87MP0004782_abnormal_surfactant_physiolog0.71345932
88MP0008057_abnormal_DNA_replication0.70915467
89MP0002066_abnormal_motor_capabilities/c0.64639259
90MP0005645_abnormal_hypothalamus_physiol0.64266347
91MP0002229_neurodegeneration0.62479078
92MP0002168_other_aberrant_phenotype0.62382620
93MP0005389_reproductive_system_phenotype0.61739490
94MP0003698_abnormal_male_reproductive0.60533600
95MP0000631_abnormal_neuroendocrine_gland0.58662531
96MP0000604_amyloidosis0.58229502
97MP0005266_abnormal_metabolism0.57967327
98MP0001963_abnormal_hearing_physiology0.57389916
99MP0003656_abnormal_erythrocyte_physiolo0.56838294
100MP0009764_decreased_sensitivity_to0.55526124

Predicted human phenotypes

RankGene SetZ-score
1Long foot (HP:0001833)5.31721237
2Chronic hepatic failure (HP:0100626)5.01743708
3Thoracic kyphosis (HP:0002942)4.96168316
4Hip dysplasia (HP:0001385)4.78668012
5Hypochromic microcytic anemia (HP:0004840)4.70579428
6Partial agenesis of the corpus callosum (HP:0001338)4.62627546
7Macroorchidism (HP:0000053)4.44109953
8Exotropia (HP:0000577)4.23305977
9Rib fusion (HP:0000902)3.87903864
10Hypochromic anemia (HP:0001931)3.86805129
11Hyperventilation (HP:0002883)3.72655872
12Abnormal biliary tract physiology (HP:0012439)3.65182626
13Bile duct proliferation (HP:0001408)3.65182626
14Protruding tongue (HP:0010808)3.62021304
15Abnormality of the thoracic spine (HP:0100711)3.46521519
16Polyphagia (HP:0002591)3.33649582
17Vertebral arch anomaly (HP:0008438)3.30040821
18Tubular atrophy (HP:0000092)3.16915461
19Abnormal number of incisors (HP:0011064)3.06338611
20Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.98666175
21Abnormality of homocysteine metabolism (HP:0010919)2.98335841
22Homocystinuria (HP:0002156)2.98335841
23Abnormal drinking behavior (HP:0030082)2.93638835
24Polydipsia (HP:0001959)2.93638835
25Nasal speech (HP:0001611)2.92433357
26Poor coordination (HP:0002370)2.85928803
27Abnormality of the phalanges of the 5th finger (HP:0004213)2.82333786
28Abnormality of the incisor (HP:0000676)2.82271392
29Pancreatic fibrosis (HP:0100732)2.81296212
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.80773962
31Absent/shortened dynein arms (HP:0200106)2.80773962
32Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.76081959
33Primary atrial arrhythmia (HP:0001692)2.75621454
34Abnormality of midbrain morphology (HP:0002418)2.75044926
35Molar tooth sign on MRI (HP:0002419)2.75044926
36Peripheral hypomyelination (HP:0007182)2.74535559
37Narrow forehead (HP:0000341)2.74244862
38Oligodontia (HP:0000677)2.70438791
39Nephronophthisis (HP:0000090)2.68359015
40Left ventricular hypertrophy (HP:0001712)2.66173172
41Abnormality of the corticospinal tract (HP:0002492)2.64841092
42Asymmetry of the thorax (HP:0001555)2.61663484
43Abnormal hair whorl (HP:0010721)2.60578704
44Limb dystonia (HP:0002451)2.58898860
45Aqueductal stenosis (HP:0002410)2.58351449
46Volvulus (HP:0002580)2.56801970
47Supraventricular tachycardia (HP:0004755)2.53461452
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.52806208
49Shawl scrotum (HP:0000049)2.48815533
50Fibular aplasia (HP:0002990)2.48269658
51Infantile muscular hypotonia (HP:0008947)2.45125232
52Abnormality of the labia minora (HP:0012880)2.45077703
53Tracheomalacia (HP:0002779)2.45065269
54Supraventricular arrhythmia (HP:0005115)2.42332114
55Progressive sensorineural hearing impairment (HP:0000408)2.41048165
56True hermaphroditism (HP:0010459)2.35560929
57Thick eyebrow (HP:0000574)2.32539777
58Severe Myopia (HP:0011003)2.30684236
59Preauricular skin tag (HP:0000384)2.28475648
60Progressive cerebellar ataxia (HP:0002073)2.28229007
61Atrial fibrillation (HP:0005110)2.26615891
62Abnormal eating behavior (HP:0100738)2.25948262
63Abnormality of the renal cortex (HP:0011035)2.25825451
64Pancreatic cysts (HP:0001737)2.24878461
65Insidious onset (HP:0003587)2.24721172
66Termporal pattern (HP:0011008)2.24721172
67Failure to thrive in infancy (HP:0001531)2.23295730
68Pointed chin (HP:0000307)2.23098610
69Acute myeloid leukemia (HP:0004808)2.20476182
70Highly arched eyebrow (HP:0002553)2.19549522
71Drooling (HP:0002307)2.08875382
72Abnormality of the renal medulla (HP:0100957)2.07960745
73Ulnar claw (HP:0001178)2.07426370
74Decreased muscle mass (HP:0003199)2.06992749
75Skin tags (HP:0010609)2.04413314
76Gait imbalance (HP:0002141)2.01572450
77Tented upper lip vermilion (HP:0010804)2.00867863
78Short philtrum (HP:0000322)1.98327129
79Excessive salivation (HP:0003781)1.95738116
80Supernumerary ribs (HP:0005815)1.90129803
81Agitation (HP:0000713)1.90043649
82Absent frontal sinuses (HP:0002688)1.89693657
83Polyuria (HP:0000103)1.88315853
84Supernumerary bones of the axial skeleton (HP:0009144)1.86208110
85Sparse lateral eyebrow (HP:0005338)1.85525315
86Esotropia (HP:0000565)1.82380444
87Abnormality of the vitamin B12 metabolism (HP:0004341)1.80654878
88Cheilitis (HP:0100825)1.78524929
89Cystic liver disease (HP:0006706)1.77583757
90Everted lower lip vermilion (HP:0000232)1.77505666
91Autoimmune thrombocytopenia (HP:0001973)1.77054038
92Labial hypoplasia (HP:0000066)1.76849835
93Congenital primary aphakia (HP:0007707)1.76651045
94Cortical dysplasia (HP:0002539)1.76566066
95Scrotal hypoplasia (HP:0000046)1.74337302
96Natal tooth (HP:0000695)1.74149807
97Gastroesophageal reflux (HP:0002020)1.71489271
98Medial flaring of the eyebrow (HP:0010747)1.70829443
99Genetic anticipation (HP:0003743)1.70347317
100Epileptic encephalopathy (HP:0200134)1.69700098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K98.72068646
2IRAK44.00225642
3MKNK23.15264077
4PKN23.07873156
5CAMK1D2.92300108
6PINK12.52392021
7SIK22.39955794
8CAMK1G2.10070368
9MKNK11.96832976
10MINK11.92782611
11MAPK131.89562577
12PRKCH1.78583816
13RPS6KA21.76305226
14TNIK1.73324670
15PAK31.66035448
16DYRK31.64668483
17CAMKK11.59599549
18WNK31.52402767
19FLT31.51365113
20SGK21.47634656
21ALK1.46894109
22CAMKK21.46256389
23CASK1.41862381
24INSRR1.31819498
25ICK1.22891157
26SIK31.12975954
27ADRBK21.11544544
28MARK31.10280952
29RPS6KA61.09148545
30RPS6KC11.06987089
31RPS6KL11.06987089
32SGK2231.06174143
33SGK4941.06174143
34MARK10.97746245
35ERBB30.97637300
36CAMK40.93011572
37DYRK1A0.92907821
38MAP3K40.86211571
39BMPR1B0.80180634
40GRK10.79543517
41BCR0.79346968
42FRK0.78414099
43CSNK1E0.74995641
44SGK30.73532443
45DYRK20.72954945
46AKT30.72146730
47CAMK10.70790166
48CDK50.68280056
49DYRK1B0.68224724
50CDK30.64091564
51UHMK10.63760667
52RET0.57366357
53CDK120.54298833
54FER0.52739499
55TAOK30.51674671
56ACVR1B0.51637437
57KIT0.51362306
58PAK60.50729555
59JAK10.49588443
60JAK20.49125962
61STK110.47206722
62PRKCZ0.45986421
63MAPK10.45981650
64TXK0.44548007
65MUSK0.43593147
66WNK10.42717819
67SGK10.42694399
68PRKCG0.41885284
69CAMK2A0.41167091
70RPS6KA10.41157167
71PKN10.40591584
72CSNK1A1L0.40386495
73CSNK1G20.39959174
74PRKAA10.36157960
75MARK20.34994904
76RPS6KB10.34614025
77MAP2K70.33137119
78PRKCE0.32607127
79CAMK2B0.32065258
80PRKCB0.31749459
81PIK3CA0.31034257
82PRKG10.30180317
83CAMK2D0.29979967
84STK380.29423112
85FGFR30.29128994
86PRKD20.29126604
87MAPK30.27690853
88ABL10.27497287
89CDK80.25528186
90PDK10.25194283
91NTRK20.24006779
92TRIB30.23065135
93ADRBK10.22632958
94RPS6KA30.22151549
95RPS6KA40.21667661
96CDK20.21021287
97MAP4K20.20990002
98CDK140.20654689
99IKBKE0.20586016
100KSR10.20482731

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.96868884
2Selenocompound metabolism_Homo sapiens_hsa004503.59114152
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.30756256
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.70770148
5Cocaine addiction_Homo sapiens_hsa050302.52739486
6Linoleic acid metabolism_Homo sapiens_hsa005912.38536501
7Ether lipid metabolism_Homo sapiens_hsa005652.33436329
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.19399227
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.97317560
10Pancreatic secretion_Homo sapiens_hsa049721.96769802
11Glutamatergic synapse_Homo sapiens_hsa047241.80953338
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80832013
13Taste transduction_Homo sapiens_hsa047421.63556935
14Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.61576302
15Morphine addiction_Homo sapiens_hsa050321.55871837
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50339508
17Circadian entrainment_Homo sapiens_hsa047131.48519490
18Synaptic vesicle cycle_Homo sapiens_hsa047211.45907969
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30694604
20Axon guidance_Homo sapiens_hsa043601.29608466
21Amphetamine addiction_Homo sapiens_hsa050311.29114746
22Butanoate metabolism_Homo sapiens_hsa006501.28047303
23Glycerophospholipid metabolism_Homo sapiens_hsa005641.27418845
24Phototransduction_Homo sapiens_hsa047441.26544901
25One carbon pool by folate_Homo sapiens_hsa006701.24344743
26Dopaminergic synapse_Homo sapiens_hsa047281.19873859
27MAPK signaling pathway_Homo sapiens_hsa040101.18674734
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14659465
29Insulin secretion_Homo sapiens_hsa049111.13628170
30Olfactory transduction_Homo sapiens_hsa047401.13364454
31GABAergic synapse_Homo sapiens_hsa047271.08235047
32Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99324329
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97776996
34Salivary secretion_Homo sapiens_hsa049700.97486861
35Long-term depression_Homo sapiens_hsa047300.97387099
36Basal transcription factors_Homo sapiens_hsa030220.97337545
37Lysine degradation_Homo sapiens_hsa003100.97294272
38Calcium signaling pathway_Homo sapiens_hsa040200.96592849
39ABC transporters_Homo sapiens_hsa020100.96014974
40Peroxisome_Homo sapiens_hsa041460.95926425
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95135001
42Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93178367
43Ovarian steroidogenesis_Homo sapiens_hsa049130.93080645
44Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91467922
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.90616388
46Tuberculosis_Homo sapiens_hsa051520.90364759
47Oxytocin signaling pathway_Homo sapiens_hsa049210.90037204
48Chemical carcinogenesis_Homo sapiens_hsa052040.89833441
49Inositol phosphate metabolism_Homo sapiens_hsa005620.85843477
50Thyroid hormone synthesis_Homo sapiens_hsa049180.85802182
51Choline metabolism in cancer_Homo sapiens_hsa052310.84418783
52Dilated cardiomyopathy_Homo sapiens_hsa054140.83287576
53cAMP signaling pathway_Homo sapiens_hsa040240.79630004
54Non-homologous end-joining_Homo sapiens_hsa034500.78769323
55Dorso-ventral axis formation_Homo sapiens_hsa043200.78195012
56Propanoate metabolism_Homo sapiens_hsa006400.78065599
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77823186
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76431823
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74641798
60Gastric acid secretion_Homo sapiens_hsa049710.74358333
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72747544
62Glycerolipid metabolism_Homo sapiens_hsa005610.69989950
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69418050
64Serotonergic synapse_Homo sapiens_hsa047260.69116769
65Collecting duct acid secretion_Homo sapiens_hsa049660.68956098
66Fatty acid biosynthesis_Homo sapiens_hsa000610.68913915
67Ras signaling pathway_Homo sapiens_hsa040140.68342997
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67301065
69Cholinergic synapse_Homo sapiens_hsa047250.65779737
70Colorectal cancer_Homo sapiens_hsa052100.65048944
71Endometrial cancer_Homo sapiens_hsa052130.64139742
72Long-term potentiation_Homo sapiens_hsa047200.63120936
73Arachidonic acid metabolism_Homo sapiens_hsa005900.62528743
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.59363792
75Phagosome_Homo sapiens_hsa041450.59288087
76Fat digestion and absorption_Homo sapiens_hsa049750.58586180
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58406895
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57568642
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.56790252
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49813880
81Nitrogen metabolism_Homo sapiens_hsa009100.49587670
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47584595
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47145864
84Protein export_Homo sapiens_hsa030600.47138654
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46442238
86Caffeine metabolism_Homo sapiens_hsa002320.45189167
87Basal cell carcinoma_Homo sapiens_hsa052170.44458153
88mTOR signaling pathway_Homo sapiens_hsa041500.40816242
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38982584
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38681960
91ErbB signaling pathway_Homo sapiens_hsa040120.38417204
92Fanconi anemia pathway_Homo sapiens_hsa034600.37592627
93Measles_Homo sapiens_hsa051620.36184215
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36026796
95RNA degradation_Homo sapiens_hsa030180.35981420
96Bile secretion_Homo sapiens_hsa049760.35420424
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34074627
98Regulation of autophagy_Homo sapiens_hsa041400.33550969
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30225014
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.29943379

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