KRT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* multicellular organismal water homeostasis (GO:0050891)9.75513030
2keratinocyte differentiation (GO:0030216)9.58438012
3skin morphogenesis (GO:0043589)8.35803949
4* water homeostasis (GO:0030104)8.07045219
5intermediate filament organization (GO:0045109)7.72566628
6epidermal cell differentiation (GO:0009913)7.32425368
7bundle of His cell to Purkinje myocyte communication (GO:0086069)7.07379784
8epidermis development (GO:0008544)6.69109402
9long-chain fatty acid biosynthetic process (GO:0042759)5.91014212
10detection of bacterium (GO:0016045)5.87276139
11glucosamine-containing compound catabolic process (GO:1901072)5.54240391
12detection of other organism (GO:0098543)5.33840909
13phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.23999404
14ectoderm development (GO:0007398)5.21452454
15intermediate filament cytoskeleton organization (GO:0045104)5.03085238
16fatty acid elongation (GO:0030497)4.96463851
17phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.94569040
18keratinocyte proliferation (GO:0043616)4.90991472
19intermediate filament-based process (GO:0045103)4.86168494
20gap junction assembly (GO:0016264)4.81022885
21phosphatidylcholine acyl-chain remodeling (GO:0036151)4.67002060
22keratinocyte development (GO:0003334)4.62667009
23skin development (GO:0043588)4.51612188
24regulation of natural killer cell differentiation (GO:0032823)4.47024708
25polarized epithelial cell differentiation (GO:0030859)4.45339963
26linoleic acid metabolic process (GO:0043651)4.42526756
27adhesion of symbiont to host cell (GO:0044650)4.37087626
28virion attachment to host cell (GO:0019062)4.37087626
29negative regulation of interferon-gamma production (GO:0032689)4.18247616
30cell-substrate junction assembly (GO:0007044)4.13146306
31phosphatidylserine metabolic process (GO:0006658)4.00383084
32regulation of keratinocyte differentiation (GO:0045616)3.93344178
33negative regulation of cell fate specification (GO:0009996)3.74828237
34atrioventricular valve morphogenesis (GO:0003181)3.72765030
35adhesion of symbiont to host (GO:0044406)3.61363512
36phospholipid catabolic process (GO:0009395)3.60052370
37ceramide biosynthetic process (GO:0046513)3.56990219
38lipoxygenase pathway (GO:0019372)3.39152097
39retinol metabolic process (GO:0042572)3.38007892
40positive regulation of keratinocyte differentiation (GO:0045618)3.34941111
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.32390673
42negative regulation of keratinocyte proliferation (GO:0010839)3.30765788
43alditol phosphate metabolic process (GO:0052646)3.24436175
44epithelial cell-cell adhesion (GO:0090136)3.17653440
45positive regulation of chemokine secretion (GO:0090197)3.16919764
46epithelium development (GO:0060429)3.14742675
47long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.14214953
48regulation of ruffle assembly (GO:1900027)3.10744538
49regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08171545
50regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.06310046
51regulation of cardioblast differentiation (GO:0051890)3.05933589
52defense response to fungus (GO:0050832)3.04739521
53one-carbon compound transport (GO:0019755)3.03783739
54keratinization (GO:0031424)24.7660793
55detection of external biotic stimulus (GO:0098581)2.99889413
56regulation of chemokine secretion (GO:0090196)2.98716643
57ventricular cardiac muscle cell action potential (GO:0086005)2.98596590
58cytoskeletal anchoring at plasma membrane (GO:0007016)2.94201462
59establishment of planar polarity (GO:0001736)2.92862316
60establishment of tissue polarity (GO:0007164)2.92862316
61cellular response to calcium ion (GO:0071277)2.89910231
62regulation of keratinocyte proliferation (GO:0010837)2.87809092
63response to phenylpropanoid (GO:0080184)2.86493071
64unsaturated fatty acid biosynthetic process (GO:0006636)2.84615374
65phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84115067
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.81968875
67phosphatidylglycerol metabolic process (GO:0046471)2.80745699
68regulation of T cell chemotaxis (GO:0010819)2.80328453
69positive regulation of T cell chemotaxis (GO:0010820)2.80328453
70regulation of epidermal cell differentiation (GO:0045604)2.79707070
71negative regulation of cell fate commitment (GO:0010454)2.79586211
72positive regulation of epidermis development (GO:0045684)2.76150878
73non-canonical Wnt signaling pathway (GO:0035567)2.74141183
74negative regulation of interleukin-17 production (GO:0032700)2.72731104
75epithelial cell proliferation (GO:0050673)2.69103534
76intestinal epithelial cell development (GO:0060576)2.68923950
77polyol transport (GO:0015791)2.67334173
78chemical homeostasis within a tissue (GO:0048875)2.65516698
79fatty-acyl-CoA biosynthetic process (GO:0046949)2.63918946
80regulation of hair cycle (GO:0042634)2.63782242
81fatty-acyl-CoA metabolic process (GO:0035337)2.63377097
82sphingolipid biosynthetic process (GO:0030148)2.60976983
83positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.60400919
84regulation of hair follicle development (GO:0051797)2.60066851
85eyelid development in camera-type eye (GO:0061029)2.57736303
86primary alcohol metabolic process (GO:0034308)2.57419590
87cellular response to antibiotic (GO:0071236)2.56741076
88sequestering of metal ion (GO:0051238)2.55796797
89detection of biotic stimulus (GO:0009595)2.54920365
90regulation of axon regeneration (GO:0048679)2.54612284
91regulation of neuron projection regeneration (GO:0070570)2.54612284
92phospholipid efflux (GO:0033700)2.52908726
93cell communication involved in cardiac conduction (GO:0086065)2.51529147
94regulation of monocyte chemotaxis (GO:0090025)2.51269771
95negative regulation of stress fiber assembly (GO:0051497)2.49595390
96regulation of heart rate by cardiac conduction (GO:0086091)2.49112202
97cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.45694107
98hair follicle development (GO:0001942)2.45348743
99molting cycle process (GO:0022404)2.45234748
100hair cycle process (GO:0022405)2.45234748
101surfactant homeostasis (GO:0043129)2.44941402
102phosphatidylserine acyl-chain remodeling (GO:0036150)2.42787168
103very long-chain fatty acid metabolic process (GO:0000038)2.41087403
104skeletal muscle adaptation (GO:0043501)2.41009689
105positive regulation of epidermal cell differentiation (GO:0045606)2.40886071
106positive regulation of hair follicle development (GO:0051798)2.39748208
107positive regulation of hair cycle (GO:0042635)2.39748208
108outer ear morphogenesis (GO:0042473)2.39728377
109regulation of glomerular filtration (GO:0003093)2.39054020
110hair follicle morphogenesis (GO:0031069)2.38515051
111tooth mineralization (GO:0034505)2.36827638
112mitotic G1 DNA damage checkpoint (GO:0031571)2.35923922
113ephrin receptor signaling pathway (GO:0048013)2.35071254
114myotube differentiation (GO:0014902)2.32771257
115positive regulation of monocyte chemotaxis (GO:0090026)2.32529005
116primary alcohol catabolic process (GO:0034310)2.31308606
117positive regulation of cholesterol efflux (GO:0010875)2.31228797
118amino sugar catabolic process (GO:0046348)2.28504733
119protein heterotrimerization (GO:0070208)2.25171806
120lateral sprouting from an epithelium (GO:0060601)2.25105030
121regulation of epidermis development (GO:0045682)2.24195850
122oocyte development (GO:0048599)2.22976261
123regulation of cell fate specification (GO:0042659)2.21127858
124bone trabecula formation (GO:0060346)2.19646912
125sphingosine metabolic process (GO:0006670)2.16123823
126hormone catabolic process (GO:0042447)2.15583492
127Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.12201362
128epithelial cell differentiation involved in prostate gland development (GO:0060742)2.10034781
129positive regulation of sterol transport (GO:0032373)2.10012272
130positive regulation of cholesterol transport (GO:0032376)2.10012272
131epithelial cell differentiation (GO:0030855)2.09296685
132wound healing (GO:0042060)2.06454141
133regulation of skeletal muscle cell differentiation (GO:2001014)2.06443920
134cardiac conduction (GO:0061337)2.05435075
135anatomical structure regression (GO:0060033)2.04794015
136regulation of establishment of planar polarity (GO:0090175)2.02684906
137* establishment of skin barrier (GO:0061436)17.6848674
138* regulation of water loss via skin (GO:0033561)15.2429825
139desmosome organization (GO:0002934)13.9440993
140hair cycle (GO:0042633)13.2224903
141molting cycle (GO:0042303)13.2224903
142hemidesmosome assembly (GO:0031581)11.7832952
143peptide cross-linking (GO:0018149)10.0943473

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.49315311
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.45856718
3ZNF263_19887448_ChIP-Seq_K562_Human3.35506851
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.72101374
5SOX9_24532713_ChIP-Seq_HFSC_Mouse2.40383399
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.05583447
7TP63_17297297_ChIP-ChIP_HaCaT_Human15.1654895
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83258141
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79501979
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79501979
11ESR1_21235772_ChIP-Seq_MCF-7_Human1.69891663
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.69496563
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.67422543
14STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66881505
15* TP63_22573176_ChIP-Seq_HFKS_Human1.56390078
16GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.53779706
17HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52104015
18RACK7_27058665_Chip-Seq_MCF-7_Human1.51660097
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50809678
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50388541
21CTCF_27219007_Chip-Seq_Bcells_Human1.49698325
22* FOXO3_23340844_ChIP-Seq_DLD1_Human1.45970544
23ATF3_27146783_Chip-Seq_COLON_Human1.44348468
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.43079350
25DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42739745
26* TP63_23658742_ChIP-Seq_EP156T_Human1.41074485
27UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.37927123
28GATA6_21074721_ChIP-Seq_CACO-2_Human1.37389657
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37065245
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.35907567
31LXR_22292898_ChIP-Seq_THP-1_Human1.35653458
32SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.34584618
33RXR_22108803_ChIP-Seq_LS180_Human1.33757078
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.32892041
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30793948
36BCOR_27268052_Chip-Seq_Bcells_Human1.30425840
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29431215
38KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25415756
39* CTCF_20526341_ChIP-Seq_ESCs_Human1.22707557
40KLF5_25053715_ChIP-Seq_YYC3_Human1.19516292
41E2F1_20622854_ChIP-Seq_HELA_Human1.18157919
42SA1_27219007_Chip-Seq_ERYTHROID_Human1.17909656
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17193984
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15144600
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.14655986
46AR_21572438_ChIP-Seq_LNCaP_Human1.14105748
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14054078
48* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13861673
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09300857
50CJUN_26792858_Chip-Seq_BT549_Human1.08484002
51TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07695310
52EGR1_19032775_ChIP-ChIP_M12_Human1.07602043
53P68_20966046_ChIP-Seq_HELA_Human1.07036065
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05003072
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.03690201
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.03151891
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.02072459
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.01708281
59YY1_22570637_ChIP-Seq_MALME-3M_Human1.01211885
60SOX2_20726797_ChIP-Seq_SW620_Human1.01020464
61KDM2B_26808549_Chip-Seq_DND41_Human1.00546050
62SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98974181
63CEBPB_22108803_ChIP-Seq_LS180_Human0.98738752
64KDM2B_26808549_Chip-Seq_K562_Human0.98359957
65ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97578916
66ERG_21242973_ChIP-ChIP_JURKAT_Human0.97490200
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95864161
68AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95297013
69P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94102556
70* ERG_20517297_ChIP-Seq_VCAP_Human0.93631426
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92671824
72TCF4_18268006_ChIP-ChIP_LS174T_Human0.92612793
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92048612
74CLOCK_20551151_ChIP-Seq_293T_Human0.90627273
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90541254
76RNF2_27304074_Chip-Seq_ESCs_Mouse0.88332785
77* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87345120
78P53_21459846_ChIP-Seq_SAOS-2_Human0.87298743
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86693484
80* BCL6_27268052_Chip-Seq_Bcells_Human0.86376803
81TAF2_19829295_ChIP-Seq_ESCs_Human0.86129911
82TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85925714
83EZH2_27304074_Chip-Seq_ESCs_Mouse0.85912742
84* EZH2_27294783_Chip-Seq_ESCs_Mouse0.85575875
85NRF2_20460467_ChIP-Seq_MEFs_Mouse0.85234343
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.85234343
87TP53_16413492_ChIP-PET_HCT116_Human0.84017795
88SMC4_20622854_ChIP-Seq_HELA_Human0.83754306
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.83465155
90SMAD4_21741376_ChIP-Seq_ESCs_Human0.83391047
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82943361
92CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.82829882
93* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82317611
94GATA4_25053715_ChIP-Seq_YYC3_Human0.81715988
95GATA6_25053715_ChIP-Seq_YYC3_Human0.81533310
96ARNT_22903824_ChIP-Seq_MCF-7_Human0.81451037
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.80630401
98RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80530625
99RBPJ_21746931_ChIP-Seq_IB4_Human0.80443844
100PPARA_22158963_ChIP-Seq_LIVER_Mouse0.78463112
101TP53_18474530_ChIP-ChIP_U2OS_Human0.78268669
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.77174231
103EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76889456
104RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76889456
105GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76820139
106PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75025916
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.74846766
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.74846766
109AHR_22903824_ChIP-Seq_MCF-7_Human0.74234235
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73951117
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73172469
112GATA2_19941826_ChIP-Seq_K562_Human0.73064053
113HNFA_21074721_ChIP-Seq_CACO-2_Human0.72489911
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72466232
115FOXM1_26456572_ChIP-Seq_MCF-7_Human0.72077170
116ESR1_20079471_ChIP-ChIP_T-47D_Human0.71126883
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.70522004
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.69912746
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.69899021
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69366658
121MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.69160980
122PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68357142
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.64464226
124FOXA1_25552417_ChIP-Seq_VCAP_Human0.62854526
125TCF4_22108803_ChIP-Seq_LS180_Human0.62799712
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.62637778
127RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62500178

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.75651897
2MP0005275_abnormal_skin_tensile7.90421517
3MP0000579_abnormal_nail_morphology5.85212428
4MP0005501_abnormal_skin_physiology5.42361841
5MP0003705_abnormal_hypodermis_morpholog4.13715558
6MP0010234_abnormal_vibrissa_follicle3.70790954
7MP0002060_abnormal_skin_morphology3.54625208
8MP0001216_abnormal_epidermal_layer3.52091472
9MP0010771_integument_phenotype3.27189587
10MP0004947_skin_inflammation3.22899673
11MP0000383_abnormal_hair_follicle3.08362816
12MP0000647_abnormal_sebaceous_gland2.95158408
13MP0002254_reproductive_system_inflammat2.83973698
14MP0003941_abnormal_skin_development2.81259068
15MP0010678_abnormal_skin_adnexa2.66890122
16MP0004381_abnormal_hair_follicle2.65954030
17MP0000467_abnormal_esophagus_morphology2.62441526
18MP0000427_abnormal_hair_cycle2.46654365
19MP0002098_abnormal_vibrissa_morphology2.40795304
20MP0000377_abnormal_hair_follicle2.39572268
21MP0003453_abnormal_keratinocyte_physiol2.28931387
22MP0000015_abnormal_ear_pigmentation2.17492281
23MP0005174_abnormal_tail_pigmentation2.04631797
24MP0001243_abnormal_dermal_layer2.01308134
25MP0000762_abnormal_tongue_morphology1.98500839
26MP0009931_abnormal_skin_appearance1.91696861
27MP0002234_abnormal_pharynx_morphology1.91009998
28MP0005451_abnormal_body_composition1.86992820
29MP0004885_abnormal_endolymph1.74482051
30MP0005377_hearing/vestibular/ear_phenot1.73894438
31MP0003878_abnormal_ear_physiology1.73894438
32MP0003566_abnormal_cell_adhesion1.64658758
33MP0001191_abnormal_skin_condition1.62270089
34MP0005075_abnormal_melanosome_morpholog1.51283743
35* MP0002095_abnormal_skin_pigmentation1.47907420
36MP0000367_abnormal_coat/_hair1.42037085
37MP0005409_darkened_coat_color1.41181647
38MP0003191_abnormal_cellular_cholesterol1.37528848
39MP0004185_abnormal_adipocyte_glucose1.33485896
40MP0008438_abnormal_cutaneous_collagen1.24762832
41MP0010030_abnormal_orbit_morphology1.21944484
42MP0001851_eye_inflammation1.13638755
43MP0001849_ear_inflammation1.07956617
44MP0009053_abnormal_anal_canal1.07208598
45MP0002177_abnormal_outer_ear0.93619791
46MP0001346_abnormal_lacrimal_gland0.92478367
47MP0002009_preneoplasia0.85796639
48MP0001340_abnormal_eyelid_morphology0.83962482
49MP0000566_synostosis0.83494398
50MP0000465_gastrointestinal_hemorrhage0.70734990
51* MP0001784_abnormal_fluid_regulation0.68105877
52MP0003300_gastrointestinal_ulcer0.67261972
53MP0005023_abnormal_wound_healing0.64822777
54MP0003755_abnormal_palate_morphology0.58039070
55MP0009780_abnormal_chondrocyte_physiolo0.57355103
56MP0001984_abnormal_olfaction0.55898658
57MP0005503_abnormal_tendon_morphology0.54329822
58MP0005257_abnormal_intraocular_pressure0.54096957
59MP0002111_abnormal_tail_morphology0.53537769
60MP0009379_abnormal_foot_pigmentation0.52717432
61MP0006054_spinal_hemorrhage0.51184024
62MP0010352_gastrointestinal_tract_polyps0.50485933
63MP0002877_abnormal_melanocyte_morpholog0.50082477
64MP0002282_abnormal_trachea_morphology0.49902296
65MP0005647_abnormal_sex_gland0.49029033
66MP0004782_abnormal_surfactant_physiolog0.48338898
67MP0000751_myopathy0.45262634
68MP0005076_abnormal_cell_differentiation0.43759157
69MP0000462_abnormal_digestive_system0.42474180
70MP0005666_abnormal_adipose_tissue0.42154238
71MP0005171_absent_coat_pigmentation0.40713681
72MP0000627_abnormal_mammary_gland0.40538059
73MP0004272_abnormal_basement_membrane0.39515785
74MP0003638_abnormal_response/metabolism_0.38949632
75MP0008004_abnormal_stomach_pH0.37932656
76MP0003385_abnormal_body_wall0.35647022
77MP0008961_abnormal_basal_metabolism0.35594829
78MP0002166_altered_tumor_susceptibility0.35058242
79MP0004858_abnormal_nervous_system0.34312135
80MP0009384_cardiac_valve_regurgitation0.34176626
81MP0009333_abnormal_splenocyte_physiolog0.34090007
82MP0000733_abnormal_muscle_development0.33695455
83MP0002249_abnormal_larynx_morphology0.32830139
84MP0005375_adipose_tissue_phenotype0.32682621
85MP0003329_amyloid_beta_deposits0.32663016
86MP0000538_abnormal_urinary_bladder0.32409977
87MP0008789_abnormal_olfactory_epithelium0.31616226
88MP0000685_abnormal_immune_system0.30289947
89MP0002006_tumorigenesis0.30028600
90MP0000749_muscle_degeneration0.28513576
91MP0003950_abnormal_plasma_membrane0.26560904
92MP0002233_abnormal_nose_morphology0.26540514
93MP0003315_abnormal_perineum_morphology0.26486728
94MP0002697_abnormal_eye_size0.26448273
95MP0001958_emphysema0.25962388
96MP0000372_irregular_coat_pigmentation0.25495811
97MP0009672_abnormal_birth_weight0.25436305
98MP0000432_abnormal_head_morphology0.25036941
99MP0005248_abnormal_Harderian_gland0.24755698
100MP0000750_abnormal_muscle_regeneration0.23786202
101MP0002896_abnormal_bone_mineralization0.22345627
102MP0003763_abnormal_thymus_physiology0.22291681
103MP0004264_abnormal_extraembryonic_tissu0.22148766
104MP0005499_abnormal_olfactory_system0.22078561
105MP0005394_taste/olfaction_phenotype0.22078561
106MP0005508_abnormal_skeleton_morphology0.21713170
107MP0000747_muscle_weakness0.21397950
108MP0003279_aneurysm0.21346807
109MP0001299_abnormal_eye_distance/0.20593851
110MP0000537_abnormal_urethra_morphology0.19950484
111MP0003448_altered_tumor_morphology0.19257066
112MP0004087_abnormal_muscle_fiber0.17502294
113MP0001542_abnormal_bone_strength0.17466968
114MP0000428_abnormal_craniofacial_morphol0.17395096
115MP0002109_abnormal_limb_morphology0.17346440
116MP0008569_lethality_at_weaning0.17218339
117MP0003011_delayed_dark_adaptation0.17002114
118MP0001177_atelectasis0.16560577
119MP0005193_abnormal_anterior_eye0.16330387
120MP0000569_abnormal_digit_pigmentation0.16271336
121MP0000759_abnormal_skeletal_muscle0.15625045
122MP0002133_abnormal_respiratory_system0.15359898
123MP0005388_respiratory_system_phenotype0.15359898
124MP0004742_abnormal_vestibular_system0.15128999
125MP0001853_heart_inflammation0.14940477
126MP0004019_abnormal_vitamin_homeostasis0.14212294
127MP0005197_abnormal_uvea_morphology0.12591584
128MP0002075_abnormal_coat/hair_pigmentati0.12449232
129MP0000371_diluted_coat_color0.12237119
130MP0004197_abnormal_fetal_growth/weight/0.12097666
131MP0003828_pulmonary_edema0.11460001

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)8.84712596
2Hypotrichosis (HP:0001006)8.26353154
3Thick nail (HP:0001805)7.92957520
4Onycholysis (HP:0001806)7.71434604
5Milia (HP:0001056)7.45073620
6* Plantar hyperkeratosis (HP:0007556)7.37492427
7* Palmoplantar hyperkeratosis (HP:0000972)7.25626711
8Pili torti (HP:0003777)6.84413272
9* Palmar hyperkeratosis (HP:0010765)6.83316796
10Abnormality of the axillary hair (HP:0100134)6.63692606
11Abnormality of secondary sexual hair (HP:0009888)6.63692606
12Woolly hair (HP:0002224)6.42123957
13Fragile nails (HP:0001808)5.76958453
14* Increased IgE level (HP:0003212)5.70923891
15Right ventricular cardiomyopathy (HP:0011663)5.34535387
16Alopecia of scalp (HP:0002293)5.22660590
17Congenital ichthyosiform erythroderma (HP:0007431)5.15585963
18* Erythema (HP:0010783)4.84004658
19Nail dystrophy (HP:0008404)4.74771832
20Follicular hyperkeratosis (HP:0007502)4.67064933
21* Abnormal blistering of the skin (HP:0008066)4.65304498
22Eczematoid dermatitis (HP:0000976)4.51834761
23Atrophic scars (HP:0001075)4.49708934
24* Conjunctival hamartoma (HP:0100780)4.44075081
25Abnormal hair laboratory examination (HP:0003328)4.28072506
26* Erythroderma (HP:0001019)4.05006882
27Ridged nail (HP:0001807)3.97857992
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.91096330
29Corneal erosion (HP:0200020)3.77434639
30Oral leukoplakia (HP:0002745)3.56288517
31Ectropion (HP:0000656)3.52978919
32* Palmoplantar keratoderma (HP:0000982)3.44687558
33Abnormality of the salivary glands (HP:0010286)3.36873163
34Advanced eruption of teeth (HP:0006288)3.18875889
35Absent hair (HP:0002298)3.17632065
36Fatigable weakness (HP:0003473)3.15944059
37Abnormality of the neuromuscular junction (HP:0003398)3.15944059
38Increased connective tissue (HP:0009025)3.15781428
39Type 1 muscle fiber predominance (HP:0003803)3.10992546
40Hypohidrosis (HP:0000966)3.08215835
41Sparse eyelashes (HP:0000653)3.03595860
42Natal tooth (HP:0000695)2.99923697
43Fragile skin (HP:0001030)2.98525034
44Pruritus (HP:0000989)2.87360638
45Ventricular tachycardia (HP:0004756)2.85745141
46* Hamartoma of the eye (HP:0010568)2.73420832
47Selective tooth agenesis (HP:0001592)2.72175729
48Aplasia involving bones of the extremities (HP:0009825)2.65253956
49Aplasia involving bones of the upper limbs (HP:0009823)2.65253956
50Aplasia of the phalanges of the hand (HP:0009802)2.65253956
51Curly hair (HP:0002212)2.62578906
52* Gangrene (HP:0100758)2.53131835
53Lip pit (HP:0100267)2.52279411
54Abnormality of the dental root (HP:0006486)2.45607441
55Taurodontia (HP:0000679)2.45607441
56Abnormality of permanent molar morphology (HP:0011071)2.45607441
57Dry hair (HP:0011359)2.43976638
58Hypoplastic labia majora (HP:0000059)2.43640901
59Hyporeflexia of lower limbs (HP:0002600)2.40082273
60Nasolacrimal duct obstruction (HP:0000579)2.38547334
61Split foot (HP:0001839)2.38531424
62Blepharitis (HP:0000498)2.38291603
63Anonychia (HP:0001798)2.36203194
64Parakeratosis (HP:0001036)2.34364417
65Abnormality of molar (HP:0011077)2.31984831
66Abnormality of molar morphology (HP:0011070)2.31984831
67Lack of skin elasticity (HP:0100679)2.31700679
68Furrowed tongue (HP:0000221)2.31189568
69Laryngomalacia (HP:0001601)2.30457788
70Conical tooth (HP:0000698)2.28601649
71Xerostomia (HP:0000217)2.27784856
72Abnormality of the labia majora (HP:0012881)2.21998505
73Round ear (HP:0100830)2.21867229
74Abnormality of the dental pulp (HP:0006479)2.17485675
75Septate vagina (HP:0001153)2.14838906
76Duplicated collecting system (HP:0000081)2.07138182
77Premature rupture of membranes (HP:0001788)2.06432519
78Pustule (HP:0200039)2.03119619
79Distal lower limb muscle weakness (HP:0009053)2.02868461
80Neonatal onset (HP:0003623)2.01255486
81Acanthosis nigricans (HP:0000956)2.00331140
82Depressed nasal tip (HP:0000437)1.98686493
83* Melanocytic nevus (HP:0000995)1.98410082
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98038078
85* Hyperhidrosis (HP:0000975)1.97417675
86Nemaline bodies (HP:0003798)1.97239439
87Muscle fiber inclusion bodies (HP:0100299)1.93114231
88Distal arthrogryposis (HP:0005684)1.90676336
89Achilles tendon contracture (HP:0001771)1.90554093
90Amniotic constriction ring (HP:0009775)1.89927734
91Abnormality of placental membranes (HP:0011409)1.89927734
92Abnormality of the lacrimal duct (HP:0011481)1.87086798
93Ventricular fibrillation (HP:0001663)1.86746409
94Urticaria (HP:0001025)1.85779740
95Fine hair (HP:0002213)1.84844302
96Recurrent corneal erosions (HP:0000495)1.79932953
97* Skin ulcer (HP:0200042)1.79884913
98Aplasia cutis congenita (HP:0001057)1.79826793
99Sparse scalp hair (HP:0002209)1.79450531
100Absent eyelashes (HP:0000561)1.78619805
101Mildly elevated creatine phosphokinase (HP:0008180)1.76679436
102Abnormality of the Achilles tendon (HP:0005109)1.75959723
103Abnormality of the renal collecting system (HP:0004742)1.75289386
104Carious teeth (HP:0000670)1.75223725
105Sudden death (HP:0001699)1.73899534
106Myopathic facies (HP:0002058)1.71693622
107Dry skin (HP:0000958)1.70668861
108Corneal dystrophy (HP:0001131)1.69825291
109Muscle fiber splitting (HP:0003555)1.69100502
110Slender build (HP:0001533)1.67494347
111Down-sloping shoulders (HP:0200021)1.67069557
112Oligodontia (HP:0000677)1.65804072
113Ankyloglossia (HP:0010296)1.65577665
114Abnormality of the nasolacrimal system (HP:0000614)1.65371881
115Autoamputation (HP:0001218)1.63994534
116Spinal rigidity (HP:0003306)1.63817629
117Increased variability in muscle fiber diameter (HP:0003557)1.62573048
118Abnormality of the gastric mucosa (HP:0004295)1.62442089
119Multifactorial inheritance (HP:0001426)1.61994466
120Breast hypoplasia (HP:0003187)1.61423293
121Peritonitis (HP:0002586)1.61134932
122* Abnormality of the fingernails (HP:0001231)1.60026702
123Calcaneovalgus deformity (HP:0001848)1.59840140
124Abnormality of skeletal muscle fiber size (HP:0012084)1.58643992
125Distal lower limb amyotrophy (HP:0008944)1.52934549
126* Hypergammaglobulinemia (HP:0010702)1.52372710
127Hypoplasia of dental enamel (HP:0006297)1.52368295
128Ulnar deviation of the wrist (HP:0003049)1.51201361
129Exercise-induced myalgia (HP:0003738)1.50669682
130Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.49036304
131Malignant hyperthermia (HP:0002047)1.46117067
132* Hamartoma (HP:0010566)1.45183783
133Coarse hair (HP:0002208)1.44885593
134Slow-growing hair (HP:0002217)1.44075293
135Abnormality of hair growth rate (HP:0011363)1.44075293
136Brittle hair (HP:0002299)1.42873918
137Paralysis (HP:0003470)1.42428529
138Anhidrosis (HP:0000970)1.42393974
139Ankle contracture (HP:0006466)1.42321045
140Dehydration (HP:0001944)1.41044386
141Unilateral renal agenesis (HP:0000122)1.40495349
142Difficulty running (HP:0009046)1.39595368
143Deformed tarsal bones (HP:0008119)1.37592677
144Neonatal death (HP:0003811)1.37222183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR15.69779915
2MST1R4.19093741
3FER4.14034107
4FGFR13.72441985
5MAPKAPK33.53960186
6MAP3K33.35584361
7ERN13.20358993
8TRIB32.95810928
9TAOK12.69161310
10TTN2.55713816
11TIE12.38802770
12MAP3K22.36091100
13MAP3K92.30307503
14PIK3CG2.28184679
15RIPK12.25874045
16MAP3K112.25560663
17LATS12.19840576
18EPHB21.98882243
19EPHA21.98619411
20PRPF4B1.77162888
21EPHB11.68713125
22EEF2K1.67539175
23MET1.60748498
24RPS6KB21.51541352
25NME11.50290183
26MAP2K61.48802144
27FGFR21.44528431
28FGFR41.34773543
29NTRK21.32259682
30OBSCN1.30122949
31MAP3K11.29954482
32SGK4941.29852232
33SGK2231.29852232
34PKN21.28679592
35RPS6KA41.25920645
36KIT1.23156607
37LATS21.23087427
38PTK61.20662002
39STK31.18327007
40MAP3K71.17398980
41EPHA31.14997222
42RPS6KB11.12198141
43SIK11.11346059
44MAP2K41.10886084
45GRK61.10844594
46MAP2K31.10753604
47NLK1.10067878
48BCR1.07919162
49MAP3K101.06446671
50IKBKB1.06437690
51MAPKAPK21.01350524
52MAP3K60.95503659
53IRAK10.92439297
54LRRK20.91385558
55FGFR30.88923438
56MAPKAPK50.84818414
57CDK60.83510674
58PRKCI0.82014199
59BMX0.81138836
60ICK0.79250554
61DMPK0.76775720
62PTK20.76489361
63STK240.76349091
64TRPM70.74984022
65TYK20.74766750
66CDK120.74141188
67PDGFRA0.73217267
68BLK0.73174208
69SGK20.71926668
70TGFBR20.71540563
71KSR20.69849823
72DYRK1B0.69419202
73MST40.67759482
74PHKG20.66151192
75PHKG10.66151192
76FGR0.65776063
77TYRO30.65555835
78DDR20.64917913
79PRKAA20.64582529
80PRKD10.64503627
81MAP2K10.56768599
82PRKD20.55258222
83SGK30.55147842
84PRKCE0.51628610
85MAPK120.51601398
86NEK10.50329994
87ILK0.49320755
88MINK10.49166449
89ERBB20.47673487
90RET0.45050919
91STK38L0.44938040
92SGK10.44036523
93RPS6KA20.43937213
94JAK30.43499442
95RPS6KA10.42415186
96TESK10.42410186
97MARK20.41807775
98HIPK20.39894342
99MAP4K10.38217559
100ADRBK10.37030374
101ERBB30.35006088
102EPHA40.33415302
103PRKCH0.32991504
104SMG10.32339743
105BRD40.31823877
106TAF10.28940139
107CDK30.28369170
108WNK10.27573387
109MAPK110.27327138
110ALK0.26657948
111MYLK0.26405801
112FYN0.26392746
113STK100.26008108
114PKN10.25269027
115CDC42BPA0.24304848
116TAOK30.23843208
117PBK0.23840285
118ROCK20.23839377
119IKBKE0.23165196
120JAK10.23010485
121SRC0.22575950
122PAK20.22218269
123PIM20.22209695
124STK110.21131574
125HCK0.21090046
126PAK30.20651721
127MTOR0.20597632
128ITK0.20350741
129LIMK10.20212019
130ABL10.19979270
131MAPK70.18762822
132MAPK40.18494385
133GSK3A0.18045166
134CDK70.17452942
135JAK20.17251495
136MAPK90.17023278
137PDGFRB0.16967447
138MAPK80.16939801
139IGF1R0.15167123
140FRK0.13907098
141MAPK30.13819563

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000622.97643854
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71823108
3Linoleic acid metabolism_Homo sapiens_hsa005912.69070281
4Basal cell carcinoma_Homo sapiens_hsa052172.65393094
5Staphylococcus aureus infection_Homo sapiens_hsa051502.33485431
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23917544
7Hedgehog signaling pathway_Homo sapiens_hsa043402.08836074
8ECM-receptor interaction_Homo sapiens_hsa045122.07959336
9Ovarian steroidogenesis_Homo sapiens_hsa049131.92285909
10VEGF signaling pathway_Homo sapiens_hsa043701.86986871
11GnRH signaling pathway_Homo sapiens_hsa049121.81246646
12Arachidonic acid metabolism_Homo sapiens_hsa005901.75616629
13Phenylalanine metabolism_Homo sapiens_hsa003601.60280163
14Melanogenesis_Homo sapiens_hsa049161.55697941
15Vitamin digestion and absorption_Homo sapiens_hsa049771.50928299
16Proteoglycans in cancer_Homo sapiens_hsa052051.48129769
17Amoebiasis_Homo sapiens_hsa051461.48102744
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.46163971
19Ether lipid metabolism_Homo sapiens_hsa005651.44898420
20Protein digestion and absorption_Homo sapiens_hsa049741.41803592
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41773606
22Steroid biosynthesis_Homo sapiens_hsa001001.40968599
23Axon guidance_Homo sapiens_hsa043601.40366708
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37224270
25Circadian rhythm_Homo sapiens_hsa047101.33942961
26Renin secretion_Homo sapiens_hsa049241.33016997
27Acute myeloid leukemia_Homo sapiens_hsa052211.30887261
28Adherens junction_Homo sapiens_hsa045201.28173983
29Fat digestion and absorption_Homo sapiens_hsa049751.27728024
30Glioma_Homo sapiens_hsa052141.26416115
31Sphingolipid metabolism_Homo sapiens_hsa006001.21915175
32Hippo signaling pathway_Homo sapiens_hsa043901.21151575
33Gastric acid secretion_Homo sapiens_hsa049711.19761158
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18432927
35Phototransduction_Homo sapiens_hsa047441.17791580
36Histidine metabolism_Homo sapiens_hsa003401.15286693
37Vascular smooth muscle contraction_Homo sapiens_hsa042701.12894283
38Estrogen signaling pathway_Homo sapiens_hsa049151.09218762
39Focal adhesion_Homo sapiens_hsa045101.07811422
40Toxoplasmosis_Homo sapiens_hsa051451.07300524
41Dorso-ventral axis formation_Homo sapiens_hsa043201.05254814
42Tight junction_Homo sapiens_hsa045301.05070337
43Long-term depression_Homo sapiens_hsa047301.02780037
44Pertussis_Homo sapiens_hsa051331.02723702
45Retinol metabolism_Homo sapiens_hsa008301.01431846
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01326444
47Long-term potentiation_Homo sapiens_hsa047201.01313259
48Notch signaling pathway_Homo sapiens_hsa043300.98350822
49Bladder cancer_Homo sapiens_hsa052190.98343291
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96067862
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95531352
52Platelet activation_Homo sapiens_hsa046110.91382399
53Oxytocin signaling pathway_Homo sapiens_hsa049210.89995777
54Salivary secretion_Homo sapiens_hsa049700.88053510
55PPAR signaling pathway_Homo sapiens_hsa033200.85954162
56Ras signaling pathway_Homo sapiens_hsa040140.85206925
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.82704092
58Insulin resistance_Homo sapiens_hsa049310.82636548
59Thyroid cancer_Homo sapiens_hsa052160.82516237
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.81352520
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80302422
62Tyrosine metabolism_Homo sapiens_hsa003500.79896176
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79411624
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77761901
65ABC transporters_Homo sapiens_hsa020100.77704951
66Rap1 signaling pathway_Homo sapiens_hsa040150.76515742
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76364106
68Wnt signaling pathway_Homo sapiens_hsa043100.73815914
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.72864442
70Pancreatic secretion_Homo sapiens_hsa049720.72696048
71MicroRNAs in cancer_Homo sapiens_hsa052060.72274701
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.71514985
73Dilated cardiomyopathy_Homo sapiens_hsa054140.71465110
74Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68735807
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.68665819
76Small cell lung cancer_Homo sapiens_hsa052220.66034544
77Nitrogen metabolism_Homo sapiens_hsa009100.65950760
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65916532
79Endometrial cancer_Homo sapiens_hsa052130.65870015
80Olfactory transduction_Homo sapiens_hsa047400.65774205
81Glutamatergic synapse_Homo sapiens_hsa047240.63152245
82Fatty acid biosynthesis_Homo sapiens_hsa000610.62702149
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62085955
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61420083
85Insulin signaling pathway_Homo sapiens_hsa049100.60793394
86Serotonergic synapse_Homo sapiens_hsa047260.58507826
87Non-small cell lung cancer_Homo sapiens_hsa052230.57977295
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.57200284
89Pathways in cancer_Homo sapiens_hsa052000.56569178
90Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56115590
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55423703
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55023955
93Circadian entrainment_Homo sapiens_hsa047130.54847510
94ErbB signaling pathway_Homo sapiens_hsa040120.54556063
95Renal cell carcinoma_Homo sapiens_hsa052110.53750515
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53186469
97Glucagon signaling pathway_Homo sapiens_hsa049220.53062788
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.52652389
99Tuberculosis_Homo sapiens_hsa051520.51829693
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50989540
101Salmonella infection_Homo sapiens_hsa051320.50354110
102Calcium signaling pathway_Homo sapiens_hsa040200.49455584
103Glycerolipid metabolism_Homo sapiens_hsa005610.48238826
104Choline metabolism in cancer_Homo sapiens_hsa052310.47206950
105Endocytosis_Homo sapiens_hsa041440.45735824
106MAPK signaling pathway_Homo sapiens_hsa040100.44466088
107beta-Alanine metabolism_Homo sapiens_hsa004100.42862405
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42340142
109Hepatitis C_Homo sapiens_hsa051600.42082829
110Gap junction_Homo sapiens_hsa045400.41831495
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41794894
112p53 signaling pathway_Homo sapiens_hsa041150.40773742
113Inositol phosphate metabolism_Homo sapiens_hsa005620.40522988
114Fatty acid metabolism_Homo sapiens_hsa012120.36855358
115Renin-angiotensin system_Homo sapiens_hsa046140.36766394
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34812055
117Pancreatic cancer_Homo sapiens_hsa052120.25010332
118Fatty acid degradation_Homo sapiens_hsa000710.24821434
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23942649
120Amphetamine addiction_Homo sapiens_hsa050310.21143273
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21129868
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20514138
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.19302612
124Influenza A_Homo sapiens_hsa051640.18539854

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