KRT10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.81542156
2* keratinocyte differentiation (GO:0030216)8.80792853
3hemidesmosome assembly (GO:0031581)8.28725285
4water homeostasis (GO:0030104)8.19905800
5peptide cross-linking (GO:0018149)8.09566181
6long-chain fatty acid biosynthetic process (GO:0042759)7.10386794
7hair cycle (GO:0042633)7.03292414
8molting cycle (GO:0042303)7.03292414
9sphingoid metabolic process (GO:0046519)6.92645132
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.92478646
11keratinocyte proliferation (GO:0043616)6.91267076
12glucosamine-containing compound catabolic process (GO:1901072)6.77464179
13* epidermal cell differentiation (GO:0009913)6.64035179
14sphingosine metabolic process (GO:0006670)6.52894577
15epidermis development (GO:0008544)5.98490910
16intermediate filament organization (GO:0045109)5.91464183
17diol metabolic process (GO:0034311)5.82515288
18skin morphogenesis (GO:0043589)5.69468788
19linoleic acid metabolic process (GO:0043651)5.41756778
20regulation of ruffle assembly (GO:1900027)5.26499303
21fatty acid elongation (GO:0030497)5.01312911
22phosphatidylserine metabolic process (GO:0006658)4.85864345
23keratinocyte development (GO:0003334)4.58112536
24regulation of phospholipase A2 activity (GO:0032429)4.48840629
25regulation of natural killer cell differentiation (GO:0032823)4.45796576
26lipoxygenase pathway (GO:0019372)4.42549704
27phosphatidylinositol acyl-chain remodeling (GO:0036149)4.41055242
28gap junction assembly (GO:0016264)4.34681387
29positive regulation of interleukin-8 secretion (GO:2000484)4.30773945
30positive regulation of monocyte chemotaxis (GO:0090026)4.28491451
31ectoderm development (GO:0007398)4.28474727
32phospholipid catabolic process (GO:0009395)4.25749035
33epithelial cell differentiation involved in prostate gland development (GO:0060742)4.24664193
34regulation of chemokine secretion (GO:0090196)4.08946374
35detection of bacterium (GO:0016045)4.07622488
36interferon-gamma secretion (GO:0072643)4.06739000
37lateral sprouting from an epithelium (GO:0060601)4.02973669
38ceramide biosynthetic process (GO:0046513)3.90407816
39alditol phosphate metabolic process (GO:0052646)3.88899588
40hair follicle morphogenesis (GO:0031069)3.84113053
41phosphatidylserine acyl-chain remodeling (GO:0036150)3.81583648
42prostaglandin biosynthetic process (GO:0001516)3.79896052
43prostanoid biosynthetic process (GO:0046457)3.79896052
44primary alcohol catabolic process (GO:0034310)3.76928875
45intermediate filament cytoskeleton organization (GO:0045104)3.75988483
46polarized epithelial cell differentiation (GO:0030859)3.71531142
47intermediate filament-based process (GO:0045103)3.63862174
48regulation of hypersensitivity (GO:0002883)3.58678967
49negative regulation of stress fiber assembly (GO:0051497)3.57408447
50regulation of keratinocyte differentiation (GO:0045616)3.57309134
51sequestering of metal ion (GO:0051238)3.53256479
52regulation of T cell chemotaxis (GO:0010819)3.52053596
53positive regulation of T cell chemotaxis (GO:0010820)3.52053596
54regulation of cell proliferation involved in kidney development (GO:1901722)3.49543764
55long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.46156404
56negative regulation of interleukin-17 production (GO:0032700)3.45150017
57detection of other organism (GO:0098543)3.40662862
58positive regulation of epidermal cell differentiation (GO:0045606)3.34825295
59fibrinolysis (GO:0042730)3.34383710
60phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.32498438
61phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.32067259
62skin development (GO:0043588)3.31903070
63amino sugar catabolic process (GO:0046348)3.26001714
64viral transcription (GO:0019083)3.21677425
65atrioventricular valve morphogenesis (GO:0003181)3.20962184
66establishment of planar polarity (GO:0001736)3.19693935
67establishment of tissue polarity (GO:0007164)3.19693935
68retinol metabolic process (GO:0042572)3.18022904
69positive regulation of keratinocyte differentiation (GO:0045618)3.16398533
70regulation of monocyte chemotaxis (GO:0090025)3.16281114
71cyclooxygenase pathway (GO:0019371)3.13252106
72response to phenylpropanoid (GO:0080184)3.12614479
73planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12418486
74surfactant homeostasis (GO:0043129)3.10694118
75positive regulation of epidermis development (GO:0045684)3.09332766
76defense response to fungus (GO:0050832)3.09182673
77regulation of interleukin-8 secretion (GO:2000482)3.08138169
78gland morphogenesis (GO:0022612)3.07611715
79prostanoid metabolic process (GO:0006692)3.05005260
80prostaglandin metabolic process (GO:0006693)3.05005260
81phospholipid scrambling (GO:0017121)3.01217795
82translational termination (GO:0006415)3.00676941
83positive regulation of chemokine secretion (GO:0090197)3.00446813
84eyelid development in camera-type eye (GO:0061029)2.98288676
85negative regulation of interferon-gamma production (GO:0032689)2.96769116
86negative regulation of cell fate specification (GO:0009996)2.94803101
87regulation of transforming growth factor beta1 production (GO:0032908)2.94612578
88phosphatidylcholine acyl-chain remodeling (GO:0036151)2.93274477
89hair cycle process (GO:0022405)2.91704280
90molting cycle process (GO:0022404)2.91704280
91ethanol metabolic process (GO:0006067)2.89407100
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88801248
93detection of external biotic stimulus (GO:0098581)2.88483915
94epithelial cell-cell adhesion (GO:0090136)2.88258849
95cardiolipin metabolic process (GO:0032048)2.86859610
96positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.86841534
97ephrin receptor signaling pathway (GO:0048013)2.86578149
98fatty-acyl-CoA metabolic process (GO:0035337)2.84599522
99adhesion of symbiont to host cell (GO:0044650)2.83433446
100virion attachment to host cell (GO:0019062)2.83433446
101epithelium development (GO:0060429)2.83072675
102one-carbon compound transport (GO:0019755)2.80896818
103negative regulation of keratinocyte proliferation (GO:0010839)2.79438428
104very long-chain fatty acid metabolic process (GO:0000038)2.78916359
105chemical homeostasis within a tissue (GO:0048875)2.78136289
106unsaturated fatty acid biosynthetic process (GO:0006636)2.76027423
107sphingolipid biosynthetic process (GO:0030148)2.75680473
108ceramide catabolic process (GO:0046514)2.73037732
109epithelial cell proliferation (GO:0050673)2.71800549
110negative regulation of axon extension involved in axon guidance (GO:0048843)2.70445651
111cardiac right ventricle morphogenesis (GO:0003215)2.69681192
112negative regulation of acute inflammatory response (GO:0002674)2.68484241
113cellular response to antibiotic (GO:0071236)2.67653951
114regulation of epidermal cell differentiation (GO:0045604)2.67642831
115phosphatidylglycerol metabolic process (GO:0046471)2.67578875
116regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.67103302
117ventricular cardiac muscle cell action potential (GO:0086005)2.65768246
118regulation of keratinocyte proliferation (GO:0010837)2.65084072
119negative regulation of interleukin-2 production (GO:0032703)2.64878224
120positive regulation of glomerulus development (GO:0090193)2.64016792
121icosanoid secretion (GO:0032309)2.62061469
122arachidonic acid secretion (GO:0050482)2.62061469
123regulation of epidermis development (GO:0045682)2.61997863
124cell-substrate junction assembly (GO:0007044)2.61538426
125negative regulation of kidney development (GO:0090185)2.57136697
126long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.55581213
127negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55288996
128regulation of cardioblast differentiation (GO:0051890)2.54922859
129positive regulation of interleukin-4 production (GO:0032753)2.53302631
130primary alcohol metabolic process (GO:0034308)2.52422384
131phosphatidic acid metabolic process (GO:0046473)2.47947947
132phosphatidic acid biosynthetic process (GO:0006654)2.47947947
133detection of biotic stimulus (GO:0009595)2.46393585
134regulation of neuron projection regeneration (GO:0070570)2.44243857
135regulation of axon regeneration (GO:0048679)2.44243857
136* epithelial cell differentiation (GO:0030855)2.44147825
137polyol transport (GO:0015791)2.43487841
138cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.37181942
139desmosome organization (GO:0002934)17.8060254
140keratinization (GO:0031424)16.6787261
141establishment of skin barrier (GO:0061436)16.6102282
142regulation of water loss via skin (GO:0033561)14.8270849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.25967313
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human3.34022760
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.75852150
4TP63_17297297_ChIP-ChIP_HaCaT_Human16.9244675
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96365604
6STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95510059
7SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.93317321
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.93317321
9ESR1_21235772_ChIP-Seq_MCF-7_Human1.91687999
10FOXO3_23340844_ChIP-Seq_DLD1_Human1.90255494
11ESR2_21235772_ChIP-Seq_MCF-7_Human1.86059564
12SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82321722
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.74502188
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60522165
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60009782
16EGR1_19032775_ChIP-ChIP_M12_Human1.59724366
17ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59517952
18ERG_20517297_ChIP-Seq_VCAP_Human1.55078745
19TP63_22573176_ChIP-Seq_HFKS_Human1.54731350
20TP63_23658742_ChIP-Seq_EP156T_Human1.53354927
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43905859
22TCF4_18268006_ChIP-ChIP_LS174T_Human1.38927197
23GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.38239788
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.36331962
25RXR_22108803_ChIP-Seq_LS180_Human1.36286398
26SMC4_20622854_ChIP-Seq_HELA_Human1.35254106
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34461370
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.34272806
29BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.29990736
30SOX2_20726797_ChIP-Seq_SW620_Human1.29163426
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28841443
32KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28409761
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24673555
34GATA6_21074721_ChIP-Seq_CACO-2_Human1.19514506
35KLF5_25053715_ChIP-Seq_YYC3_Human1.18649069
36AR_21572438_ChIP-Seq_LNCaP_Human1.17382587
37* E2F1_20622854_ChIP-Seq_HELA_Human1.16879458
38ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16869643
39RACK7_27058665_Chip-Seq_MCF-7_Human1.14755186
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14654698
41* ZNF263_19887448_ChIP-Seq_K562_Human1.14212261
42CJUN_26792858_Chip-Seq_BT549_Human1.14048043
43ATF3_27146783_Chip-Seq_COLON_Human1.13457162
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13033464
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09366587
46GATA3_24758297_ChIP-Seq_MCF-7_Human1.08827571
47CTCF_27219007_Chip-Seq_Bcells_Human1.07459707
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04343933
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03961757
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03779568
51CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02679127
52* BCL6_27268052_Chip-Seq_Bcells_Human1.02228067
53P53_21459846_ChIP-Seq_SAOS-2_Human1.00373793
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00154024
55TP53_20018659_ChIP-ChIP_R1E_Mouse1.00122244
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96252332
57SA1_27219007_Chip-Seq_ERYTHROID_Human0.96111733
58* CEBPB_22108803_ChIP-Seq_LS180_Human0.95890276
59LXR_22292898_ChIP-Seq_THP-1_Human0.95796711
60TP53_18474530_ChIP-ChIP_U2OS_Human0.94601826
61AHR_22903824_ChIP-Seq_MCF-7_Human0.94383834
62GATA4_25053715_ChIP-Seq_YYC3_Human0.91953607
63CTCF_20526341_ChIP-Seq_ESCs_Human0.91589278
64YY1_22570637_ChIP-Seq_MALME-3M_Human0.90841800
65BCAT_22108803_ChIP-Seq_LS180_Human0.90770963
66* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.90460252
67UBF1/2_26484160_Chip-Seq_HMECs_Human0.90457991
68ESR1_20079471_ChIP-ChIP_T-47D_Human0.90196183
69* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88663222
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.88120566
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86963167
72GATA6_25053715_ChIP-Seq_YYC3_Human0.86540675
73CDX2_20551321_ChIP-Seq_CACO-2_Human0.86274402
74P300_27268052_Chip-Seq_Bcells_Human0.85677423
75AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85484452
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.85067094
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.84322387
78EZH2_27294783_Chip-Seq_ESCs_Mouse0.83193028
79SMAD4_21741376_ChIP-Seq_ESCs_Human0.83047927
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81585634
81SA1_27219007_Chip-Seq_Bcells_Human0.81334662
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80538374
83JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.80534570
84* BCOR_27268052_Chip-Seq_Bcells_Human0.80234969
85PPARA_22158963_ChIP-Seq_LIVER_Mouse0.80121383
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.79815105
87TCF4_22108803_ChIP-Seq_LS180_Human0.77620065
88RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75685598
89GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.75043926
90JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73674614
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73304390
92* TAF2_19829295_ChIP-Seq_ESCs_Human0.72983362
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72020875
94KDM2B_26808549_Chip-Seq_K562_Human0.71835219
95NANOG_18555785_ChIP-Seq_MESCs_Mouse0.71518775
96P68_20966046_ChIP-Seq_HELA_Human0.71509197
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.71146190
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.70416691
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.68791559
100GATA3_21867929_ChIP-Seq_TH1_Mouse0.68772961
101RBPJ_21746931_ChIP-Seq_IB4_Human0.68759345
102EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.67861104
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67698643
104FOXH1_21741376_ChIP-Seq_ESCs_Human0.67596285
105NCOR_22424771_ChIP-Seq_293T_Human0.66266143
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65867121
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.64425671
108CLOCK_20551151_ChIP-Seq_293T_Human0.64282385
109GATA1_19941826_ChIP-Seq_K562_Human0.64196929
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.64064141
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.63438734
112SOX2_27498859_Chip-Seq_STOMACH_Mouse0.62660647
113GATA2_21666600_ChIP-Seq_HMVEC_Human0.62182004
114SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.62163638
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.62011695
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.61125476
117JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.61108270
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.60885445
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.60632547
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.60632547
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.59415033
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.58651473
123GATA1_22025678_ChIP-Seq_K562_Human0.58056065
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.57637488
125CBX2_22325352_ChIP-Seq_293T-Rex_Human0.56900622
126OCT1_27270436_Chip-Seq_PROSTATE_Human0.56847565
127PPAR_26484153_Chip-Seq_NCI-H1993_Human0.56844224
128PHF8_20622853_ChIP-Seq_HELA_Human0.56573522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.20760961
2MP0005501_abnormal_skin_physiology5.75812357
3* MP0005275_abnormal_skin_tensile5.53413629
4MP0003941_abnormal_skin_development4.83815286
5MP0010234_abnormal_vibrissa_follicle4.61931332
6* MP0001216_abnormal_epidermal_layer3.76978654
7MP0002254_reproductive_system_inflammat3.73077879
8MP0000579_abnormal_nail_morphology3.73058446
9* MP0002060_abnormal_skin_morphology3.41455902
10* MP0010771_integument_phenotype3.37402492
11MP0004947_skin_inflammation3.18566855
12MP0004381_abnormal_hair_follicle3.14153505
13MP0003453_abnormal_keratinocyte_physiol3.08428859
14MP0000383_abnormal_hair_follicle3.06387626
15MP0003705_abnormal_hypodermis_morpholog2.93268849
16MP0000647_abnormal_sebaceous_gland2.77982375
17MP0010678_abnormal_skin_adnexa2.73388935
18MP0002098_abnormal_vibrissa_morphology2.63500177
19MP0000467_abnormal_esophagus_morphology2.58755464
20MP0000015_abnormal_ear_pigmentation2.38145305
21MP0000377_abnormal_hair_follicle2.30754403
22MP0005451_abnormal_body_composition2.28711168
23MP0005174_abnormal_tail_pigmentation2.21002099
24MP0000566_synostosis2.20910253
25MP0000427_abnormal_hair_cycle2.14832768
26MP0004885_abnormal_endolymph1.92619315
27MP0001191_abnormal_skin_condition1.89331857
28MP0004185_abnormal_adipocyte_glucose1.88116429
29* MP0009931_abnormal_skin_appearance1.88088099
30MP0003566_abnormal_cell_adhesion1.88028351
31MP0005377_hearing/vestibular/ear_phenot1.77768120
32MP0003878_abnormal_ear_physiology1.77768120
33MP0000762_abnormal_tongue_morphology1.73563502
34MP0001243_abnormal_dermal_layer1.68571499
35MP0001188_hyperpigmentation1.62925702
36MP0001346_abnormal_lacrimal_gland1.49802961
37MP0002234_abnormal_pharynx_morphology1.38783191
38* MP0000367_abnormal_coat/_hair1.35059495
39MP0003191_abnormal_cellular_cholesterol1.19565265
40MP0009379_abnormal_foot_pigmentation1.12354316
41MP0003011_delayed_dark_adaptation1.06377302
42MP0001340_abnormal_eyelid_morphology1.04828342
43MP0002009_preneoplasia1.03835223
44MP0001851_eye_inflammation1.01149431
45MP0009053_abnormal_anal_canal0.98914086
46MP0008004_abnormal_stomach_pH0.93481338
47MP0010352_gastrointestinal_tract_polyps0.87620384
48MP0002095_abnormal_skin_pigmentation0.85935947
49MP0010030_abnormal_orbit_morphology0.81348093
50MP0004782_abnormal_surfactant_physiolog0.79368001
51MP0000465_gastrointestinal_hemorrhage0.77643316
52MP0002877_abnormal_melanocyte_morpholog0.74802682
53MP0005023_abnormal_wound_healing0.74149490
54MP0001784_abnormal_fluid_regulation0.73084080
55MP0001984_abnormal_olfaction0.62788626
56MP0003763_abnormal_thymus_physiology0.59880374
57MP0002006_tumorigenesis0.59036681
58MP0009780_abnormal_chondrocyte_physiolo0.57690025
59MP0000627_abnormal_mammary_gland0.56607783
60MP0004019_abnormal_vitamin_homeostasis0.54971519
61MP0005666_abnormal_adipose_tissue0.54090051
62MP0005076_abnormal_cell_differentiation0.53381387
63MP0001849_ear_inflammation0.50107551
64MP0008961_abnormal_basal_metabolism0.50075648
65MP0001186_pigmentation_phenotype0.49941243
66MP0003436_decreased_susceptibility_to0.48836225
67MP0003300_gastrointestinal_ulcer0.45782778
68MP0006054_spinal_hemorrhage0.43591490
69MP0002166_altered_tumor_susceptibility0.43553809
70MP0003950_abnormal_plasma_membrane0.43072132
71MP0005409_darkened_coat_color0.42372541
72MP0000538_abnormal_urinary_bladder0.39832530
73MP0003755_abnormal_palate_morphology0.39329421
74MP0008789_abnormal_olfactory_epithelium0.38479845
75* MP0002177_abnormal_outer_ear0.37105625
76MP0005248_abnormal_Harderian_gland0.36339982
77MP0003638_abnormal_response/metabolism_0.36304916
78MP0003329_amyloid_beta_deposits0.36226549
79MP0000685_abnormal_immune_system0.35974528
80MP0004264_abnormal_extraembryonic_tissu0.35717097
81MP0005499_abnormal_olfactory_system0.35316369
82MP0005394_taste/olfaction_phenotype0.35316369
83* MP0002111_abnormal_tail_morphology0.33792567
84MP0005647_abnormal_sex_gland0.33784062
85MP0002148_abnormal_hypersensitivity_rea0.33257840
86MP0002282_abnormal_trachea_morphology0.32440070
87MP0005171_absent_coat_pigmentation0.32389189
88MP0005503_abnormal_tendon_morphology0.31670550
89MP0002249_abnormal_larynx_morphology0.31628928
90MP0000470_abnormal_stomach_morphology0.31410351
91MP0005375_adipose_tissue_phenotype0.31195745
92MP0003315_abnormal_perineum_morphology0.31009646
93MP0003385_abnormal_body_wall0.30169350
94MP0009384_cardiac_valve_regurgitation0.28382230
95MP0005075_abnormal_melanosome_morpholog0.28226057
96MP0001177_atelectasis0.27847119
97MP0009333_abnormal_splenocyte_physiolog0.27281185
98MP0004858_abnormal_nervous_system0.26550605
99MP0000613_abnormal_salivary_gland0.25736169
100MP0000516_abnormal_urinary_system0.24789451
101MP0005367_renal/urinary_system_phenotyp0.24789451
102MP0000537_abnormal_urethra_morphology0.23797343
103MP0001666_abnormal_nutrient_absorption0.23317302
104MP0008438_abnormal_cutaneous_collagen0.22992159
105MP0000462_abnormal_digestive_system0.21939123
106MP0005388_respiratory_system_phenotype0.21719868
107MP0002133_abnormal_respiratory_system0.21719868
108MP0005508_abnormal_skeleton_morphology0.21426408
109MP0004272_abnormal_basement_membrane0.21412167
110MP0000372_irregular_coat_pigmentation0.20049584
111MP0005257_abnormal_intraocular_pressure0.19940844
112MP0002075_abnormal_coat/hair_pigmentati0.18864227
113MP0002233_abnormal_nose_morphology0.18702872
114MP0009672_abnormal_birth_weight0.18307633
115MP0001958_emphysema0.18221587
116MP0002277_abnormal_respiratory_mucosa0.16934294
117MP0003938_abnormal_ear_development0.16618478
118MP0000432_abnormal_head_morphology0.16444762
119MP0004197_abnormal_fetal_growth/weight/0.16242232
120MP0000428_abnormal_craniofacial_morphol0.14249109
121MP0001299_abnormal_eye_distance/0.13134038
122MP0000750_abnormal_muscle_regeneration0.13132370
123MP0002971_abnormal_brown_adipose0.12225299
124MP0002090_abnormal_vision0.12173826
125MP0000371_diluted_coat_color0.10417434
126MP0005193_abnormal_anterior_eye0.08965283
127MP0000858_altered_metastatic_potential0.08791994
128MP0001485_abnormal_pinna_reflex0.05217146
129MP0003448_altered_tumor_morphology0.05051409

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)9.07978988
2Hypotrichosis (HP:0001006)8.30872130
3Congenital ichthyosiform erythroderma (HP:0007431)7.03753695
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.81259831
5Woolly hair (HP:0002224)6.81220325
6* Plantar hyperkeratosis (HP:0007556)6.68841813
7Right ventricular cardiomyopathy (HP:0011663)6.54341309
8* Palmoplantar hyperkeratosis (HP:0000972)6.46019668
9Onycholysis (HP:0001806)6.23266461
10* Palmar hyperkeratosis (HP:0010765)6.04735722
11* Erythema (HP:0010783)5.79233561
12Abnormality of nail color (HP:0100643)5.46213679
13Parakeratosis (HP:0001036)5.36592804
14Thick nail (HP:0001805)5.34158854
15Milia (HP:0001056)5.27748978
16Lip pit (HP:0100267)5.16223392
17Oral leukoplakia (HP:0002745)5.12330931
18Pili torti (HP:0003777)5.08514935
19Fragile nails (HP:0001808)4.92030455
20Gangrene (HP:0100758)4.83003611
21* Erythroderma (HP:0001019)4.68841013
22Corneal erosion (HP:0200020)4.38180672
23* Abnormal blistering of the skin (HP:0008066)4.33379697
24Ectropion (HP:0000656)4.32366282
25* Conjunctival hamartoma (HP:0100780)4.23518901
26Abnormality of secondary sexual hair (HP:0009888)4.04076792
27Abnormality of the axillary hair (HP:0100134)4.04076792
28Nail dystrophy (HP:0008404)3.83393132
29Hypohidrosis (HP:0000966)3.75212305
30* Palmoplantar keratoderma (HP:0000982)3.69650098
31Ventricular tachycardia (HP:0004756)3.63112420
32Pruritus (HP:0000989)3.58331710
33Curly hair (HP:0002212)3.56103902
34Hyporeflexia of lower limbs (HP:0002600)3.54376964
35Absent eyelashes (HP:0000561)3.45822090
36Natal tooth (HP:0000695)3.43049086
37Advanced eruption of teeth (HP:0006288)3.38949245
38Abnormal hair laboratory examination (HP:0003328)3.27141674
39Sparse eyelashes (HP:0000653)3.24403916
40Distal lower limb muscle weakness (HP:0009053)3.10124710
41Ridged nail (HP:0001807)3.04827087
42Sparse scalp hair (HP:0002209)3.03850451
43Absent hair (HP:0002298)2.96788388
44Popliteal pterygium (HP:0009756)2.92964131
45Atrophic scars (HP:0001075)2.85033858
46Hypergammaglobulinemia (HP:0010702)2.79339858
47Abnormality of the salivary glands (HP:0010286)2.72047056
48Acanthosis nigricans (HP:0000956)2.70362946
49Furrowed tongue (HP:0000221)2.59312416
50Alopecia of scalp (HP:0002293)2.58109519
51Ventricular fibrillation (HP:0001663)2.50161169
52Lack of skin elasticity (HP:0100679)2.46297370
53Amniotic constriction ring (HP:0009775)2.43506541
54Abnormality of placental membranes (HP:0011409)2.43506541
55Areflexia of lower limbs (HP:0002522)2.39365485
56Slow-growing hair (HP:0002217)2.34408999
57Abnormality of hair growth rate (HP:0011363)2.34408999
58Blepharitis (HP:0000498)2.33611150
59* Hamartoma of the eye (HP:0010568)2.32334094
60Hypoplastic labia majora (HP:0000059)2.30069594
61Abnormality of the neuromuscular junction (HP:0003398)2.28854393
62Fatigable weakness (HP:0003473)2.28854393
63Increased connective tissue (HP:0009025)2.25668755
64Myopathic facies (HP:0002058)2.14144893
65Eczematoid dermatitis (HP:0000976)2.10934758
66Round ear (HP:0100830)2.09393822
67Severe Myopia (HP:0011003)2.08383875
68Abnormality of the gastric mucosa (HP:0004295)2.07799181
69Fragile skin (HP:0001030)2.06931633
70Down-sloping shoulders (HP:0200021)2.06844810
71Abnormality of the labia majora (HP:0012881)2.06699682
72Xerostomia (HP:0000217)2.06055129
73Split foot (HP:0001839)2.00306139
74Dry skin (HP:0000958)1.99727889
75Recurrent corneal erosions (HP:0000495)1.99439550
76Conical tooth (HP:0000698)1.95834415
77Pterygium (HP:0001059)1.95009192
78Nasolacrimal duct obstruction (HP:0000579)1.94557336
79Achilles tendon contracture (HP:0001771)1.94088863
80* Melanocytic nevus (HP:0000995)1.93800554
81Hyperhidrosis (HP:0000975)1.90977051
82Congenital, generalized hypertrichosis (HP:0004540)1.89678698
83Selective tooth agenesis (HP:0001592)1.87943651
84Autoamputation (HP:0001218)1.87063502
85Sudden death (HP:0001699)1.86916163
86Abnormality of permanent molar morphology (HP:0011071)1.86367047
87Abnormality of the dental root (HP:0006486)1.86367047
88Taurodontia (HP:0000679)1.86367047
89Dehydration (HP:0001944)1.86360370
90Neonatal death (HP:0003811)1.83776438
91Urticaria (HP:0001025)1.81186511
92Duplicated collecting system (HP:0000081)1.80789569
93Type 1 muscle fiber predominance (HP:0003803)1.78988374
94Abnormality of the Achilles tendon (HP:0005109)1.78682447
95Laryngomalacia (HP:0001601)1.78198588
96Follicular hyperkeratosis (HP:0007502)1.76884718
97Distal arthrogryposis (HP:0005684)1.76492302
98* Skin ulcer (HP:0200042)1.75996341
99Abnormality of molar morphology (HP:0011070)1.75951116
100Abnormality of molar (HP:0011077)1.75951116
101Aplasia cutis congenita (HP:0001057)1.75286469
102Anonychia (HP:0001798)1.74860036
103Malignant hyperthermia (HP:0002047)1.69348091
104Trismus (HP:0000211)1.67895076
105Abnormality of the distal phalanges of the toes (HP:0010182)1.65854311
106Aplasia involving bones of the upper limbs (HP:0009823)1.65591427
107Aplasia of the phalanges of the hand (HP:0009802)1.65591427
108Aplasia involving bones of the extremities (HP:0009825)1.65591427
109Multifactorial inheritance (HP:0001426)1.63910234
110Abnormality of the dental pulp (HP:0006479)1.63817773
111Septate vagina (HP:0001153)1.63603851
112Verrucae (HP:0200043)1.61384660
113Papilloma (HP:0012740)1.61384660
114* Hamartoma (HP:0010566)1.60035401
115Fine hair (HP:0002213)1.58376511
116Paralysis (HP:0003470)1.57778503
117Skin pits (HP:0100276)1.55711073
118Nemaline bodies (HP:0003798)1.54100413
119Abnormality of the renal collecting system (HP:0004742)1.53930706
120Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.53117776
121Dry hair (HP:0011359)1.47882612
122Muscle fiber inclusion bodies (HP:0100299)1.47550141
123Abnormality of the lacrimal duct (HP:0011481)1.46717526
124Hypoplasia of dental enamel (HP:0006297)1.45449106
125Exercise-induced myalgia (HP:0003738)1.45321860
126Brittle hair (HP:0002299)1.44022768
127Sepsis (HP:0100806)1.42808460
128Ankyloglossia (HP:0010296)1.42768459
129Carious teeth (HP:0000670)1.42759233
130Hypodontia (HP:0000668)1.42618061
131Abnormality of the fingernails (HP:0001231)1.41834171
132Pustule (HP:0200039)1.40750090
133Depressed nasal tip (HP:0000437)1.37417999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.54219619
2MAPKAPK35.46203111
3TGFBR15.14718475
4MAP3K34.32112695
5FER3.50204913
6MST43.18579987
7MAP3K23.17744732
8RPS6KB22.55530286
9MET2.31488135
10PIK3CG2.31481343
11ERN12.24574807
12PRPF4B2.20916424
13PIM22.17246712
14MAP3K111.90456905
15MAPKAPK51.81007275
16STK241.78475053
17TRPM71.77567384
18BLK1.77240732
19EEF2K1.71620919
20LATS11.71530188
21MAP2K61.58732445
22TAOK11.56019710
23MAP3K91.55633756
24FGFR11.47721876
25NTRK21.45997741
26MAPK71.45523218
27EPHB21.42426683
28TTN1.41415052
29FGFR21.34007978
30EPHA21.30774502
31DYRK1B1.29482027
32GRK61.26850233
33LRRK21.26547026
34MAP3K11.18161818
35RIPK11.13793186
36ERBB31.09970349
37IRAK11.06994574
38MAP3K121.04602723
39BCR1.02687623
40PTK61.02650149
41IKBKB1.01496309
42TESK11.01043573
43MAPKAPK21.00759885
44MAP3K70.97750628
45PBK0.97742014
46CDK120.97287618
47MAP2K40.97027336
48SGK2230.92909918
49SGK4940.92909918
50STK100.91832043
51NLK0.91491278
52RPS6KB10.90397311
53EPHA30.89695609
54RPS6KA40.85586339
55FGFR40.81503699
56PRKCI0.77788106
57SMG10.77751458
58MAP3K60.77369194
59CDK60.76840496
60LATS20.73182591
61TRIB30.71531300
62KIT0.70955797
63SIK10.65807767
64ILK0.64291739
65TYRO30.64241367
66MINK10.63494123
67FGFR30.63309483
68CDK190.62531508
69OBSCN0.62394003
70LIMK10.61630749
71STK30.60854011
72TGFBR20.60087322
73RIPK40.59633067
74PRKD10.58699807
75RET0.57046185
76MAPK110.56909127
77PKN10.56893452
78CDK30.56815588
79ICK0.56308770
80PRKAA20.54858826
81KSR20.54682115
82MAP2K30.54578559
83PRKD20.54040479
84MAP3K50.51076609
85MTOR0.51015797
86ABL20.50796883
87NME20.49245648
88JAK30.48317120
89PAK30.47898403
90NME10.47714286
91MYLK0.47632395
92MAP2K10.47262140
93ITK0.47230104
94DMPK0.46368840
95MAPK120.45312923
96EPHB10.44598197
97MAP3K140.43741471
98TYK20.35987339
99ADRBK10.35914469
100TIE10.35710331
101PTK20.35440614
102MARK20.34982321
103BRAF0.33016332
104CDK70.32912309
105EPHA40.32314129
106HIPK20.32219638
107SGK10.30674363
108SGK20.30615365
109STK110.30575481
110MAPK90.30497311
111JAK20.30414659
112DDR20.29736845
113GRK70.29293704
114GSK3A0.29013889
115SGK30.28989721
116LMTK20.28267110
117ERBB20.27862156
118CDC42BPA0.27198889
119PDGFRA0.26477584
120CSNK1D0.25458646
121ROCK20.24749667
122TTK0.22759562
123SRC0.22669610
124RPS6KA10.21538829
125FGR0.20642157
126MAPK40.18899868
127CSNK1E0.18128358
128BMX0.17764771
129RAF10.16934466
130RPS6KA20.16844895
131MAP2K20.15807230
132GRK10.15478364
133STK38L0.15142197
134PRKCE0.15007145
135HCK0.14562265
136JAK10.14433710
137MAPK130.13112311
138TESK20.12131845
139PRKCD0.11982101
140PDK20.10677649
141ABL10.10458024

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005914.04022665
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.93540880
3Sphingolipid metabolism_Homo sapiens_hsa006003.86959034
4Arachidonic acid metabolism_Homo sapiens_hsa005903.37497310
5Fatty acid elongation_Homo sapiens_hsa000622.93081666
6Phenylalanine metabolism_Homo sapiens_hsa003602.55770099
7Ribosome_Homo sapiens_hsa030102.48780928
8Ether lipid metabolism_Homo sapiens_hsa005652.35706928
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.26634350
10Histidine metabolism_Homo sapiens_hsa003402.18757398
11VEGF signaling pathway_Homo sapiens_hsa043702.15873096
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82075169
13GnRH signaling pathway_Homo sapiens_hsa049121.58918185
14Axon guidance_Homo sapiens_hsa043601.55333401
15Tyrosine metabolism_Homo sapiens_hsa003501.46908925
16Sphingolipid signaling pathway_Homo sapiens_hsa040711.46456140
17Basal cell carcinoma_Homo sapiens_hsa052171.44995872
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.44435262
19Retinol metabolism_Homo sapiens_hsa008301.41326263
20Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37083333
21Steroid biosynthesis_Homo sapiens_hsa001001.35528186
22Serotonergic synapse_Homo sapiens_hsa047261.31477545
23Renin secretion_Homo sapiens_hsa049241.28770718
24Long-term depression_Homo sapiens_hsa047301.28682951
25p53 signaling pathway_Homo sapiens_hsa041151.23266440
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20348382
27Tight junction_Homo sapiens_hsa045301.16458071
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15046192
29Pancreatic secretion_Homo sapiens_hsa049721.13605680
30Adherens junction_Homo sapiens_hsa045201.11714327
31Vitamin digestion and absorption_Homo sapiens_hsa049771.09296493
32Chemical carcinogenesis_Homo sapiens_hsa052041.06285371
33ECM-receptor interaction_Homo sapiens_hsa045121.04536028
34Bladder cancer_Homo sapiens_hsa052191.02402197
35Caffeine metabolism_Homo sapiens_hsa002321.00587814
36Proteoglycans in cancer_Homo sapiens_hsa052051.00026257
37Hedgehog signaling pathway_Homo sapiens_hsa043400.99004094
38Melanogenesis_Homo sapiens_hsa049160.98652609
39ABC transporters_Homo sapiens_hsa020100.98145422
40Fat digestion and absorption_Homo sapiens_hsa049750.97882330
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95867678
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.95429161
43beta-Alanine metabolism_Homo sapiens_hsa004100.95196334
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92087268
45Dorso-ventral axis formation_Homo sapiens_hsa043200.89988629
46Platelet activation_Homo sapiens_hsa046110.89920617
47Ras signaling pathway_Homo sapiens_hsa040140.88176167
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.87358469
49Ovarian steroidogenesis_Homo sapiens_hsa049130.83501269
50Hippo signaling pathway_Homo sapiens_hsa043900.82523736
51Gastric acid secretion_Homo sapiens_hsa049710.82196256
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80950033
53Circadian rhythm_Homo sapiens_hsa047100.78420345
54Amoebiasis_Homo sapiens_hsa051460.75465487
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75431386
56Fatty acid biosynthesis_Homo sapiens_hsa000610.74692412
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74655436
58Pertussis_Homo sapiens_hsa051330.74644506
59Phototransduction_Homo sapiens_hsa047440.74351505
60MicroRNAs in cancer_Homo sapiens_hsa052060.73951611
61ErbB signaling pathway_Homo sapiens_hsa040120.71214713
62Acute myeloid leukemia_Homo sapiens_hsa052210.70546534
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69466609
64Oxytocin signaling pathway_Homo sapiens_hsa049210.68967289
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66427031
66Thyroid cancer_Homo sapiens_hsa052160.66288078
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63363770
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62823774
69* Staphylococcus aureus infection_Homo sapiens_hsa051500.62783968
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.61835833
71Salivary secretion_Homo sapiens_hsa049700.60539254
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59477609
73Hepatitis C_Homo sapiens_hsa051600.57430137
74Estrogen signaling pathway_Homo sapiens_hsa049150.57392034
75Toxoplasmosis_Homo sapiens_hsa051450.56830404
76Glioma_Homo sapiens_hsa052140.56654212
77Long-term potentiation_Homo sapiens_hsa047200.55853478
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55760357
79Choline metabolism in cancer_Homo sapiens_hsa052310.50078560
80Rap1 signaling pathway_Homo sapiens_hsa040150.48706282
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46246093
82Endometrial cancer_Homo sapiens_hsa052130.45699696
83Protein digestion and absorption_Homo sapiens_hsa049740.45403303
84Calcium signaling pathway_Homo sapiens_hsa040200.45343764
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44667401
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.41067812
87Wnt signaling pathway_Homo sapiens_hsa043100.40688759
88Collecting duct acid secretion_Homo sapiens_hsa049660.38947774
89Glutamatergic synapse_Homo sapiens_hsa047240.38783718
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.38609257
91Endocytosis_Homo sapiens_hsa041440.36103105
92Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35814275
93PPAR signaling pathway_Homo sapiens_hsa033200.34556004
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34012697
95Notch signaling pathway_Homo sapiens_hsa043300.33473008
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.31916165
97Salmonella infection_Homo sapiens_hsa051320.31794528
98MAPK signaling pathway_Homo sapiens_hsa040100.31550801
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31536024
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.30172428
101Inositol phosphate metabolism_Homo sapiens_hsa005620.29625448
102Non-small cell lung cancer_Homo sapiens_hsa052230.28500140
103Gap junction_Homo sapiens_hsa045400.28366622
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28252284
105Mineral absorption_Homo sapiens_hsa049780.27210750
106Insulin resistance_Homo sapiens_hsa049310.27195174
107Glycerolipid metabolism_Homo sapiens_hsa005610.26901221
108Insulin signaling pathway_Homo sapiens_hsa049100.26544742
109Fatty acid metabolism_Homo sapiens_hsa012120.26314568
110Tuberculosis_Homo sapiens_hsa051520.25922171
111Circadian entrainment_Homo sapiens_hsa047130.25855530
112Renal cell carcinoma_Homo sapiens_hsa052110.25692657
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24856273
114Olfactory transduction_Homo sapiens_hsa047400.24147628
115Arginine biosynthesis_Homo sapiens_hsa002200.22631049
116Amphetamine addiction_Homo sapiens_hsa050310.21527862
117Fatty acid degradation_Homo sapiens_hsa000710.19004130
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17060035
119Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17003751
120Glucagon signaling pathway_Homo sapiens_hsa049220.16820908
121Dopaminergic synapse_Homo sapiens_hsa047280.16717216
122Arginine and proline metabolism_Homo sapiens_hsa003300.14868227
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.13360306
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.12882657

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