KRT16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ectoderm development (GO:0007398)9.10865189
2keratinocyte differentiation (GO:0030216)8.99737357
3skin morphogenesis (GO:0043589)7.68375273
4multicellular organismal water homeostasis (GO:0050891)7.46624229
5* epidermis development (GO:0008544)7.45281803
6bundle of His cell to Purkinje myocyte communication (GO:0086069)7.35679827
7epidermal cell differentiation (GO:0009913)6.70762220
8fatty acid elongation (GO:0030497)6.20183497
9water homeostasis (GO:0030104)6.19456258
10* intermediate filament cytoskeleton organization (GO:0045104)5.70692039
11* intermediate filament-based process (GO:0045103)5.51329342
12surfactant homeostasis (GO:0043129)5.30279791
13cell-substrate junction assembly (GO:0007044)5.24045713
14keratinocyte development (GO:0003334)5.17712209
15negative regulation of interferon-gamma production (GO:0032689)4.80446677
16regulation of natural killer cell differentiation (GO:0032823)4.67292873
17chemical homeostasis within a tissue (GO:0048875)4.51549815
18adhesion of symbiont to host cell (GO:0044650)4.43222397
19virion attachment to host cell (GO:0019062)4.43222397
20negative regulation of keratinocyte proliferation (GO:0010839)4.33112140
21long-chain fatty acid biosynthetic process (GO:0042759)4.28056387
22skin development (GO:0043588)4.20812133
23phosphatidylcholine acyl-chain remodeling (GO:0036151)4.13742073
24sequestering of metal ion (GO:0051238)3.84673401
25keratinocyte proliferation (GO:0043616)3.83436640
26negative regulation of interleukin-17 production (GO:0032700)3.78575684
27adhesion of symbiont to host (GO:0044406)3.75319636
28polarized epithelial cell differentiation (GO:0030859)3.70052729
29positive regulation of T cell chemotaxis (GO:0010820)3.67936862
30regulation of T cell chemotaxis (GO:0010819)3.67936862
31positive regulation of keratinocyte differentiation (GO:0045618)3.61313221
32positive regulation of monocyte chemotaxis (GO:0090026)3.60582638
33gap junction assembly (GO:0016264)3.49550972
34atrioventricular valve morphogenesis (GO:0003181)3.48529871
35phosphatidylinositol acyl-chain remodeling (GO:0036149)3.45937924
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.45446446
37long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.40907539
38* epithelium development (GO:0060429)3.38499252
39regulation of transforming growth factor beta1 production (GO:0032908)3.33418542
40long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.31800503
41positive regulation of epidermis development (GO:0045684)3.30185607
42negative regulation of cell fate specification (GO:0009996)3.27363373
43ventricular cardiac muscle cell action potential (GO:0086005)3.20979533
44positive regulation of cellular amide metabolic process (GO:0034250)3.19211365
45fatty-acyl-CoA biosynthetic process (GO:0046949)3.16480600
46detection of external biotic stimulus (GO:0098581)3.10993436
47lateral sprouting from an epithelium (GO:0060601)3.09857864
48ceramide biosynthetic process (GO:0046513)3.06729809
49phosphatidylserine acyl-chain remodeling (GO:0036150)3.05200342
50fibrinolysis (GO:0042730)3.04906860
51cellular response to interleukin-4 (GO:0071353)3.00398242
52keratinization (GO:0031424)22.3873132
53positive regulation of epidermal cell differentiation (GO:0045606)2.99281293
54alditol phosphate metabolic process (GO:0052646)2.95014261
55regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.92890667
56cytoskeletal anchoring at plasma membrane (GO:0007016)2.90493915
57linoleic acid metabolic process (GO:0043651)2.88315936
58regulation of cardioblast differentiation (GO:0051890)2.86189204
59regulation of monocyte chemotaxis (GO:0090025)2.84871548
60planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82221056
61defense response to fungus (GO:0050832)2.80387430
62detection of bacterium (GO:0016045)2.80344725
63fatty-acyl-CoA metabolic process (GO:0035337)2.74538423
64positive regulation of hair follicle development (GO:0051798)2.74337532
65positive regulation of hair cycle (GO:0042635)2.74337532
66epithelial cell-cell adhesion (GO:0090136)2.72742383
67defense response to Gram-negative bacterium (GO:0050829)2.70964124
68hair follicle morphogenesis (GO:0031069)2.69533054
69regulation of hair follicle development (GO:0051797)2.67271274
70response to UV-B (GO:0010224)2.66671698
71very long-chain fatty acid metabolic process (GO:0000038)2.64765284
72regulation of epidermis development (GO:0045682)2.64631813
73regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.63226761
74establishment of planar polarity (GO:0001736)2.62624196
75establishment of tissue polarity (GO:0007164)2.62624196
76regulation of heart rate by cardiac conduction (GO:0086091)2.62408789
77detection of biotic stimulus (GO:0009595)2.61023363
78eyelid development in camera-type eye (GO:0061029)2.60435081
79phospholipid catabolic process (GO:0009395)2.60414960
80cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.58274289
81intestinal epithelial cell development (GO:0060576)2.58081864
82wound healing (GO:0042060)2.56911017
83response to interleukin-4 (GO:0070670)2.55915436
84cell communication involved in cardiac conduction (GO:0086065)2.55488320
85regulation of hair cycle (GO:0042634)2.55301308
86regulation of protein localization to cell surface (GO:2000008)2.53290894
87regulation of axon regeneration (GO:0048679)2.51283424
88regulation of neuron projection regeneration (GO:0070570)2.51283424
89antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50771207
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50771207
91negative regulation of epidermis development (GO:0045683)2.46993886
92* epithelial cell differentiation (GO:0030855)2.46429757
93positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.46120709
94citrulline biosynthetic process (GO:0019240)2.45818036
95phospholipid efflux (GO:0033700)2.43885399
96detection of other organism (GO:0098543)2.41598461
97regulation of ruffle assembly (GO:1900027)2.40527537
98thioester biosynthetic process (GO:0035384)2.38729294
99acyl-CoA biosynthetic process (GO:0071616)2.38729294
100positive regulation of cell cycle checkpoint (GO:1901978)2.36038978
101cardiac conduction (GO:0061337)2.35740323
102dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.34734169
103lipoxygenase pathway (GO:0019372)2.34397180
104positive regulation of p38MAPK cascade (GO:1900745)2.33748974
105phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.32124122
106regulation of keratinocyte differentiation (GO:0045616)2.31954918
107positive regulation of protein export from nucleus (GO:0046827)2.31901563
108hormone catabolic process (GO:0042447)2.30827471
109positive regulation of cholesterol efflux (GO:0010875)2.30717262
110regulation of keratinocyte proliferation (GO:0010837)2.29777663
111cell junction organization (GO:0034330)2.29028736
112epithelial cell proliferation (GO:0050673)2.29008366
113regulation of epidermal cell differentiation (GO:0045604)2.23748720
114phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.23383359
115negative regulation of cell fate commitment (GO:0010454)2.22215805
116actin-myosin filament sliding (GO:0033275)2.21899377
117muscle filament sliding (GO:0030049)2.21899377
118cell junction assembly (GO:0034329)2.21424324
119protein localization to endosome (GO:0036010)2.20715128
120amyloid precursor protein metabolic process (GO:0042982)2.20524471
121hair cycle process (GO:0022405)2.18772457
122molting cycle process (GO:0022404)2.18772457
123positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.18049075
124phosphatidylserine metabolic process (GO:0006658)2.18048104
125interleukin-1-mediated signaling pathway (GO:0070498)2.17021954
126negative regulation of cardiac muscle tissue growth (GO:0055022)2.16770710
127negative regulation of heart growth (GO:0061117)2.16770710
128antigen processing and presentation of endogenous antigen (GO:0019883)2.12249647
129* molting cycle (GO:0042303)15.3750077
130* hair cycle (GO:0042633)15.3750077
131hemidesmosome assembly (GO:0031581)15.2642546
132desmosome organization (GO:0002934)13.8803350
133establishment of skin barrier (GO:0061436)12.9352463
134regulation of water loss via skin (GO:0033561)11.4021756
135intermediate filament organization (GO:0045109)11.0004908
136peptide cross-linking (GO:0018149)10.1617324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.51145594
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44708676
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.83319569
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.70721071
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.08266515
6TP63_17297297_ChIP-ChIP_HaCaT_Human17.0301769
7* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.97994539
8* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.97994539
9ZNF263_19887448_ChIP-Seq_K562_Human1.88996467
10SOX9_24532713_ChIP-Seq_HFSC_Mouse1.87996892
11TRIM28_21343339_ChIP-Seq_HEK293_Human1.76125829
12ESR1_21235772_ChIP-Seq_MCF-7_Human1.64670816
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63865944
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54151128
15RACK7_27058665_Chip-Seq_MCF-7_Human1.49877024
16* ATF3_27146783_Chip-Seq_COLON_Human1.48676661
17FOXO3_23340844_ChIP-Seq_DLD1_Human1.47780294
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.45126174
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39717378
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37247628
21STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36033354
22E2F1_20622854_ChIP-Seq_HELA_Human1.34992999
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.34529707
24UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31146882
25TP63_22573176_ChIP-Seq_HFKS_Human1.28159607
26KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26778064
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26116610
28DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25343854
29LXR_22292898_ChIP-Seq_THP-1_Human1.23711936
30ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22577944
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22268735
32SOX2_20726797_ChIP-Seq_SW620_Human1.20177088
33* EGR1_19032775_ChIP-ChIP_M12_Human1.19414683
34CLOCK_20551151_ChIP-Seq_293T_Human1.18114471
35P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.16945272
36GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.16853539
37CTCF_20526341_ChIP-Seq_ESCs_Human1.16698515
38CTCF_27219007_Chip-Seq_Bcells_Human1.16510069
39TP63_23658742_ChIP-Seq_EP156T_Human1.15661088
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15408715
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13752650
42ERG_20517297_ChIP-Seq_VCAP_Human1.12742406
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.11793060
44BCOR_27268052_Chip-Seq_Bcells_Human1.07882801
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.07791894
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.05646427
47KLF5_25053715_ChIP-Seq_YYC3_Human1.04824786
48RXR_22108803_ChIP-Seq_LS180_Human1.04186993
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02100025
50CJUN_26792858_Chip-Seq_BT549_Human1.00508663
51GATA6_21074721_ChIP-Seq_CACO-2_Human0.99851777
52TCF4_18268006_ChIP-ChIP_LS174T_Human0.99067402
53SA1_27219007_Chip-Seq_ERYTHROID_Human0.98256437
54* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.97437249
55JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96812538
56* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96030493
57JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93847413
58SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92042324
59BCL6_27268052_Chip-Seq_Bcells_Human0.91759769
60RUNX1_27514584_Chip-Seq_MCF-7_Human0.91567006
61PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90959412
62P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90130780
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89843828
64YY1_22570637_ChIP-Seq_MALME-3M_Human0.89785889
65ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87181352
66CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86139413
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86126420
68TAF2_19829295_ChIP-Seq_ESCs_Human0.85974352
69KDM2B_26808549_Chip-Seq_DND41_Human0.85130995
70BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83773104
71AR_21572438_ChIP-Seq_LNCaP_Human0.83739975
72TP53_20018659_ChIP-ChIP_R1E_Mouse0.82946759
73BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.82290184
74SMC4_20622854_ChIP-Seq_HELA_Human0.81336338
75* P68_20966046_ChIP-Seq_HELA_Human0.81306045
76ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81227513
77SUZ12_27294783_Chip-Seq_ESCs_Mouse0.81218186
78* NANOG_20526341_ChIP-Seq_ESCs_Human0.81026484
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.78298902
80CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77346281
81TP53_18474530_ChIP-ChIP_U2OS_Human0.77101839
82RAC3_21632823_ChIP-Seq_H3396_Human0.77085965
83FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77046366
84ERG_21242973_ChIP-ChIP_JURKAT_Human0.76919074
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76859278
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75546784
87ESR1_20079471_ChIP-ChIP_T-47D_Human0.73607716
88GATA6_25053715_ChIP-Seq_YYC3_Human0.71764482
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.71472229
90KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71197585
91KDM2B_26808549_Chip-Seq_K562_Human0.70834246
92CEBPB_22108803_ChIP-Seq_LS180_Human0.70477866
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.68544394
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.67630263
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.66860157
96JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.65700047
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.64517956
98AHR_22903824_ChIP-Seq_MCF-7_Human0.64438957
99* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63713585
100ELF1_20517297_ChIP-Seq_JURKAT_Human0.63158055
101CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62722963
102THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.62696505
103KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.62585165
104JARID2_20075857_ChIP-Seq_MESCs_Mouse0.61951154
105* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61430343
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.61193638
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.60620174
108SMAD4_21741376_ChIP-Seq_ESCs_Human0.60419039
109GATA4_25053715_ChIP-Seq_YYC3_Human0.60333211
110TBX20_22080862_ChIP-Seq_HEART_Mouse0.60286764
111TBX20_22328084_ChIP-Seq_HEART_Mouse0.60286764
112FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.60189986
113RBPJ_21746931_ChIP-Seq_IB4_Human0.60063169
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.58213156
115TP53_16413492_ChIP-PET_HCT116_Human0.57895405
116CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.54110448
117TET1_21490601_ChIP-Seq_MESCs_Mouse0.53288862
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.53245300
119TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.52623828
120PPARA_22158963_ChIP-Seq_LIVER_Mouse0.50532568
121* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.50352039
122HNFA_21074721_ChIP-Seq_CACO-2_Human0.50350221
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.49975315
124P53_21459846_ChIP-Seq_SAOS-2_Human0.47941627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology9.03722827
2MP0002796_impaired_skin_barrier7.46460658
3MP0005275_abnormal_skin_tensile5.61747529
4MP0000467_abnormal_esophagus_morphology4.70461554
5MP0005501_abnormal_skin_physiology4.69469825
6MP0000383_abnormal_hair_follicle3.67808130
7MP0004381_abnormal_hair_follicle3.66492349
8MP0010234_abnormal_vibrissa_follicle3.54695684
9MP0001216_abnormal_epidermal_layer3.39760431
10MP0003705_abnormal_hypodermis_morpholog3.26442240
11MP0010678_abnormal_skin_adnexa3.18613386
12MP0003453_abnormal_keratinocyte_physiol3.04260737
13MP0000762_abnormal_tongue_morphology2.96200269
14MP0010771_integument_phenotype2.83248267
15MP0002060_abnormal_skin_morphology2.82162106
16MP0005409_darkened_coat_color2.77862166
17MP0000647_abnormal_sebaceous_gland2.55646439
18MP0000377_abnormal_hair_follicle2.47287575
19MP0004947_skin_inflammation2.45504244
20MP0002098_abnormal_vibrissa_morphology2.27769205
21MP0002254_reproductive_system_inflammat2.24971529
22MP0000427_abnormal_hair_cycle2.15211368
23MP0003941_abnormal_skin_development2.06194172
24MP0003566_abnormal_cell_adhesion2.03570165
25MP0003878_abnormal_ear_physiology1.90294734
26MP0005377_hearing/vestibular/ear_phenot1.90294734
27MP0002234_abnormal_pharynx_morphology1.81429202
28MP0009931_abnormal_skin_appearance1.64809174
29MP0000367_abnormal_coat/_hair1.48167466
30MP0001191_abnormal_skin_condition1.43026189
31MP0005451_abnormal_body_composition1.41969032
32MP0004185_abnormal_adipocyte_glucose1.40301251
33MP0009053_abnormal_anal_canal1.39420089
34MP0001243_abnormal_dermal_layer1.36737891
35MP0005023_abnormal_wound_healing1.36579348
36MP0001849_ear_inflammation1.28008825
37MP0003191_abnormal_cellular_cholesterol1.27258833
38MP0008438_abnormal_cutaneous_collagen1.19180519
39MP0001851_eye_inflammation1.15729203
40MP0000465_gastrointestinal_hemorrhage1.07416544
41MP0009379_abnormal_foot_pigmentation1.03185363
42MP0002282_abnormal_trachea_morphology1.01238014
43MP0003755_abnormal_palate_morphology0.85481086
44MP0008260_abnormal_autophagy0.71105818
45MP0004264_abnormal_extraembryonic_tissu0.68699630
46MP0001188_hyperpigmentation0.67299803
47MP0004885_abnormal_endolymph0.66275550
48MP0010352_gastrointestinal_tract_polyps0.65185681
49MP0008789_abnormal_olfactory_epithelium0.63385973
50MP0003315_abnormal_perineum_morphology0.63027963
51MP0005075_abnormal_melanosome_morpholog0.61728113
52MP0003950_abnormal_plasma_membrane0.61692894
53MP0001340_abnormal_eyelid_morphology0.57924984
54MP0004272_abnormal_basement_membrane0.57071208
55MP0001784_abnormal_fluid_regulation0.56848832
56MP0001346_abnormal_lacrimal_gland0.53330766
57MP0005499_abnormal_olfactory_system0.47903289
58MP0005394_taste/olfaction_phenotype0.47903289
59MP0000678_abnormal_parathyroid_gland0.45169696
60MP0005666_abnormal_adipose_tissue0.44653990
61MP0000751_myopathy0.43598236
62MP0002877_abnormal_melanocyte_morpholog0.43190280
63MP0003436_decreased_susceptibility_to0.40362366
64MP0005257_abnormal_intraocular_pressure0.39441476
65MP0000538_abnormal_urinary_bladder0.38393878
66MP0004782_abnormal_surfactant_physiolog0.35664539
67MP0000627_abnormal_mammary_gland0.35640023
68MP0002111_abnormal_tail_morphology0.34416797
69MP0000749_muscle_degeneration0.34177492
70MP0003329_amyloid_beta_deposits0.33590830
71MP0000566_synostosis0.32593466
72MP0005375_adipose_tissue_phenotype0.32135050
73MP0000015_abnormal_ear_pigmentation0.32000773
74MP0004858_abnormal_nervous_system0.31267085
75MP0004043_abnormal_pH_regulation0.31166639
76MP0003011_delayed_dark_adaptation0.31072858
77MP0005193_abnormal_anterior_eye0.30779395
78MP0006054_spinal_hemorrhage0.29624374
79MP0000858_altered_metastatic_potential0.29531093
80MP0010030_abnormal_orbit_morphology0.29334537
81MP0002177_abnormal_outer_ear0.29247745
82MP0003448_altered_tumor_morphology0.27213945
83MP0000733_abnormal_muscle_development0.26685071
84MP0005076_abnormal_cell_differentiation0.26613665
85MP0002095_abnormal_skin_pigmentation0.25961473
86MP0000750_abnormal_muscle_regeneration0.25577914
87MP0000537_abnormal_urethra_morphology0.24413977
88MP0000747_muscle_weakness0.24064567
89MP0001533_abnormal_skeleton_physiology0.23437059
90MP0003300_gastrointestinal_ulcer0.23210362
91MP0003763_abnormal_thymus_physiology0.22434450
92MP0002233_abnormal_nose_morphology0.22252715
93MP0003303_peritoneal_inflammation0.21880685
94MP0001186_pigmentation_phenotype0.21559929
95MP0001177_atelectasis0.21066446
96MP0001542_abnormal_bone_strength0.20926442
97MP0008004_abnormal_stomach_pH0.20729351
98MP0000604_amyloidosis0.20643904
99MP0003385_abnormal_body_wall0.20465753
100MP0008569_lethality_at_weaning0.20017717
101MP0004197_abnormal_fetal_growth/weight/0.19792404
102MP0004087_abnormal_muscle_fiber0.19765279
103MP0000462_abnormal_digestive_system0.19719664
104MP0000003_abnormal_adipose_tissue0.19480820
105MP0005197_abnormal_uvea_morphology0.18271522
106MP0002006_tumorigenesis0.18127394
107MP0003638_abnormal_response/metabolism_0.17432600
108MP0003075_altered_response_to0.17344738
109MP0000343_altered_response_to0.16936141
110MP0002896_abnormal_bone_mineralization0.16784683
111MP0002697_abnormal_eye_size0.16615474
112MP0001299_abnormal_eye_distance/0.16386124
113MP0000470_abnormal_stomach_morphology0.15771206
114MP0001958_emphysema0.15453540
115MP0003828_pulmonary_edema0.15295774
116MP0002166_altered_tumor_susceptibility0.14589400
117MP0002090_abnormal_vision0.14588701
118MP0004019_abnormal_vitamin_homeostasis0.14549570
119MP0005388_respiratory_system_phenotype0.13762038
120MP0002133_abnormal_respiratory_system0.13762038
121MP0009780_abnormal_chondrocyte_physiolo0.13328121
122MP0003045_fibrosis0.13170030
123MP0009840_abnormal_foam_cell0.12701503
124MP0000759_abnormal_skeletal_muscle0.12388419
125MP0005174_abnormal_tail_pigmentation0.12229986
126MP0002075_abnormal_coat/hair_pigmentati0.11010471

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)8.72527171
2* Plantar hyperkeratosis (HP:0007556)7.41567278
3* Thick nail (HP:0001805)7.41533163
4Fragile nails (HP:0001808)7.29509723
5Onycholysis (HP:0001806)7.26556674
6Milia (HP:0001056)7.25966744
7* Palmoplantar hyperkeratosis (HP:0000972)7.10550000
8Increased IgE level (HP:0003212)6.89085036
9* Palmar hyperkeratosis (HP:0010765)6.68934674
10Hypotrichosis (HP:0001006)6.67254301
11Woolly hair (HP:0002224)6.12284650
12Nail dystrophy (HP:0008404)5.31622066
13* Abnormal blistering of the skin (HP:0008066)5.28844465
14Abnormality of secondary sexual hair (HP:0009888)4.99962262
15Abnormality of the axillary hair (HP:0100134)4.99962262
16Pili torti (HP:0003777)4.94643276
17Right ventricular cardiomyopathy (HP:0011663)4.94592905
18Ridged nail (HP:0001807)4.76120726
19Erythroderma (HP:0001019)4.42251794
20Erythema (HP:0010783)4.40030661
21Conjunctival hamartoma (HP:0100780)3.97798967
22Fatigable weakness (HP:0003473)3.96410877
23Abnormality of the neuromuscular junction (HP:0003398)3.96410877
24Congenital ichthyosiform erythroderma (HP:0007431)3.80691010
25Atrophic scars (HP:0001075)3.74817329
26* Laryngomalacia (HP:0001601)3.65655944
27* Palmoplantar keratoderma (HP:0000982)3.61170714
28Hypohidrosis (HP:0000966)3.21807501
29* Anonychia (HP:0001798)3.08687230
30Abnormal hair laboratory examination (HP:0003328)3.07507820
31Abnormality of the salivary glands (HP:0010286)3.07489745
32Ectropion (HP:0000656)3.07113607
33* Corneal dystrophy (HP:0001131)3.06033901
34Absent hair (HP:0002298)3.03990109
35Gangrene (HP:0100758)3.00751964
36Corneal erosion (HP:0200020)2.95568407
37* Hyperhidrosis (HP:0000975)2.94748277
38Sparse eyelashes (HP:0000653)2.74159429
39Pustule (HP:0200039)2.72943854
40Natal tooth (HP:0000695)2.71317901
41Advanced eruption of teeth (HP:0006288)2.70092528
42Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.66353414
43Hamartoma of the eye (HP:0010568)2.53975249
44Ventricular tachycardia (HP:0004756)2.52285708
45Neonatal onset (HP:0003623)2.50065077
46Lip pit (HP:0100267)2.42855192
47Selective tooth agenesis (HP:0001592)2.37303266
48* Carious teeth (HP:0000670)2.36863513
49Increased connective tissue (HP:0009025)2.36153391
50* Oral leukoplakia (HP:0002745)2.35580608
51Type 1 muscle fiber predominance (HP:0003803)2.33858472
52Curly hair (HP:0002212)2.29608296
53Hypoplastic labia majora (HP:0000059)2.26461187
54Parakeratosis (HP:0001036)2.26459039
55Pruritus (HP:0000989)2.24811287
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24517391
57Multifactorial inheritance (HP:0001426)2.23482956
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22893402
59* Abnormality of the fingernails (HP:0001231)2.20736690
60Popliteal pterygium (HP:0009756)2.19063996
61Axonal loss (HP:0003447)2.18757671
62Muscle fiber inclusion bodies (HP:0100299)2.15871165
63Hypergammaglobulinemia (HP:0010702)2.13339032
64Fragile skin (HP:0001030)2.09210946
65Round ear (HP:0100830)2.08481701
66Nemaline bodies (HP:0003798)2.07743484
67Abnormality of the labia majora (HP:0012881)2.05126473
68Skin ulcer (HP:0200042)2.04329133
69* Abnormality of nail color (HP:0100643)14.8824509
70Blepharitis (HP:0000498)1.98976789
71Hyporeflexia of lower limbs (HP:0002600)1.97308079
72Aplasia cutis congenita (HP:0001057)1.96465241
73Muscle fiber splitting (HP:0003555)1.95450413
74Lack of skin elasticity (HP:0100679)1.92606390
75Slow-growing hair (HP:0002217)1.87430733
76Abnormality of hair growth rate (HP:0011363)1.87430733
77Distal arthrogryposis (HP:0005684)1.87169481
78Myopathic facies (HP:0002058)1.81485374
79Absent eyelashes (HP:0000561)1.77547749
80Brittle hair (HP:0002299)1.76361322
81Keratoconjunctivitis sicca (HP:0001097)1.72355783
82Recurrent corneal erosions (HP:0000495)1.71772548
83Achilles tendon contracture (HP:0001771)1.70546235
84Ankyloglossia (HP:0010296)1.69598819
85Ulnar deviation of the wrist (HP:0003049)1.67482497
86Acanthosis nigricans (HP:0000956)1.66668951
87Fine hair (HP:0002213)1.65376043
88Autoamputation (HP:0001218)1.63892394
89Sudden death (HP:0001699)1.62863901
90Calcaneovalgus deformity (HP:0001848)1.60027713
91Dry skin (HP:0000958)1.60025746
92Ventricular fibrillation (HP:0001663)1.59268529
93Abnormality of the Achilles tendon (HP:0005109)1.57895062
94Paralysis (HP:0003470)1.57106545
95Epidermoid cyst (HP:0200040)1.56612620
96Keratoconjunctivitis (HP:0001096)1.56515760
97Distal lower limb muscle weakness (HP:0009053)1.55807411
98Premature rupture of membranes (HP:0001788)1.55607104
99Neck muscle weakness (HP:0000467)1.55138574
100Segmental peripheral demyelination/remyelination (HP:0003481)1.54857041
101Distal lower limb amyotrophy (HP:0008944)1.54227042
102Xerostomia (HP:0000217)1.52340568
103Melanocytic nevus (HP:0000995)1.51951854
104Sepsis (HP:0100806)1.50915788
105Abnormality of placental membranes (HP:0011409)1.50619658
106Amniotic constriction ring (HP:0009775)1.50619658
107Squamous cell carcinoma (HP:0002860)1.49188861
108Oligodontia (HP:0000677)1.48904315
109Dry hair (HP:0011359)1.48682305
110Sparse scalp hair (HP:0002209)1.48282892
111Exercise-induced myalgia (HP:0003738)1.47936014
112Furrowed tongue (HP:0000221)1.45669179
113Hypoplastic toenails (HP:0001800)1.43199972
114Protrusio acetabuli (HP:0003179)1.41589716
115Deformed tarsal bones (HP:0008119)1.39046762
116Labial hypoplasia (HP:0000066)1.38540006
117Split foot (HP:0001839)1.38190116
118Eczematoid dermatitis (HP:0000976)1.38174431
119Urticaria (HP:0001025)1.37053021
120Septate vagina (HP:0001153)1.36989284
121Abnormal auditory evoked potentials (HP:0006958)1.36061199
122Exercise-induced muscle cramps (HP:0003710)1.35548274
123Duplicated collecting system (HP:0000081)1.35220127
124Hypoplasia of dental enamel (HP:0006297)1.34821657
125Pterygium (HP:0001059)1.33863667
126Dehydration (HP:0001944)1.32480158
127Amelogenesis imperfecta (HP:0000705)1.31362753
128Difficulty running (HP:0009046)1.31260627
129Esophageal atresia (HP:0002032)1.31029087

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.54955636
2FER4.30722137
3TGFBR13.63978605
4TRIB33.62297410
5MST1R3.46512124
6MAP3K33.16208729
7MAPKAPK32.77259452
8EPHA22.69825259
9PIK3CG2.66137820
10TTN2.58393370
11EPHB12.39727471
12NME12.30785265
13TAOK12.17585514
14RPS6KA42.16498236
15SGK2232.12904000
16SGK4942.12904000
17BLK1.99434970
18EPHA31.98488241
19FGFR41.95676680
20ARAF1.94713227
21MAP3K111.89274182
22MAP3K61.81210869
23LATS11.72968969
24EPHB21.70645561
25TYK21.65021516
26NTRK11.64914456
27RIPK11.64683649
28EEF2K1.60522528
29PKN21.59858720
30MAP3K91.52940317
31MET1.51759749
32MAP3K21.50867705
33TESK11.40685289
34DDR21.36771105
35MAP2K31.30695847
36FGFR31.29267082
37TGFBR21.28675376
38MAP3K11.28323921
39MAP2K61.27469493
40FGFR11.21594505
41PTK61.20119141
42LATS21.15543652
43LIMK11.14073279
44RPS6KB21.12938723
45STK241.12259615
46CDK121.10561416
47LRRK21.10425139
48PIM21.09461232
49FLT31.08883917
50TRPM71.06775689
51NEK11.06373818
52GRK61.04637403
53STK38L1.04072328
54PRPF4B1.03317824
55MST41.03090668
56OBSCN1.00438556
57IRAK10.99992827
58PDGFRA0.96794787
59PTK20.96620729
60BCR0.88731477
61BMX0.84962834
62IKBKB0.83046543
63CDK60.82671134
64MAPKAPK20.82368315
65MAP3K120.82336162
66DMPK0.80527550
67IRAK30.80412371
68MAP2K10.79898745
69ERBB30.78813269
70JAK10.78730520
71STK380.78605416
72MAP2K40.77497015
73MAP3K70.77292479
74STK30.77127892
75PRKD20.71533843
76STK100.65920818
77SMG10.65344110
78KSR20.64713480
79ILK0.62703678
80PAK20.60314889
81PHKG20.59731855
82PHKG10.59731855
83MAPK70.57340252
84LMTK20.56676704
85FGR0.55727620
86MAP3K130.55150206
87RET0.54653229
88ALK0.52540903
89WNK10.52341885
90RPS6KA10.52094937
91TBK10.50170178
92PBK0.49926198
93MTOR0.49898612
94MAPK120.49741495
95JAK30.48829510
96MAP3K50.47345876
97NEK60.47025986
98FGFR20.46833725
99MAPKAPK50.46437423
100NTRK20.45658797
101BRAF0.45077605
102SGK10.45034088
103ADRBK10.45020988
104MOS0.44820407
105CDC42BPA0.43491036
106PRKD10.43223641
107JAK20.41629093
108SIK10.40852973
109IRAK20.40018099
110MARK20.38382571
111RPS6KA20.37365550
112RPS6KB10.37255506
113HCK0.36371698
114ABL20.33238579
115KIT0.32647877
116GSK3A0.32157345
117RAF10.30627948
118MAP3K80.30176551
119TYRO30.29432814
120ROCK20.29041447
121MAPK40.28990868
122SGK30.28848018
123DYRK1B0.28740099
124SRC0.27853574
125IRAK40.27769062
126PRKCI0.27673905
127CSK0.27254025
128FYN0.26834774
129PRKCE0.26511292
130ABL10.22221159
131ERBB20.21067999
132RPS6KC10.19954602
133RPS6KL10.19954602
134IKBKE0.19861311
135PAK40.19839224
136EGFR0.19216473
137MAPK110.18198365
138ROCK10.17715936
139PAK30.17419776
140PDGFRB0.16601094
141MAPK80.15965277

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.98449439
2Fatty acid elongation_Homo sapiens_hsa000623.63139319
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.20812353
4Linoleic acid metabolism_Homo sapiens_hsa005913.18470399
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68858270
6ECM-receptor interaction_Homo sapiens_hsa045122.47284048
7Arachidonic acid metabolism_Homo sapiens_hsa005901.95644286
8Ether lipid metabolism_Homo sapiens_hsa005651.89597609
9Phenylalanine metabolism_Homo sapiens_hsa003601.88950826
10Caffeine metabolism_Homo sapiens_hsa002321.86238235
11VEGF signaling pathway_Homo sapiens_hsa043701.83960661
12Fat digestion and absorption_Homo sapiens_hsa049751.81922260
13Ovarian steroidogenesis_Homo sapiens_hsa049131.80305267
14Amoebiasis_Homo sapiens_hsa051461.58447102
15Staphylococcus aureus infection_Homo sapiens_hsa051501.48614336
16GnRH signaling pathway_Homo sapiens_hsa049121.47401963
17Proteoglycans in cancer_Homo sapiens_hsa052051.47175176
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46576081
19Steroid biosynthesis_Homo sapiens_hsa001001.44437784
20Acute myeloid leukemia_Homo sapiens_hsa052211.43724408
21Toxoplasmosis_Homo sapiens_hsa051451.42151903
22Focal adhesion_Homo sapiens_hsa045101.38444768
23Histidine metabolism_Homo sapiens_hsa003401.36873602
24Bladder cancer_Homo sapiens_hsa052191.28355831
25Pertussis_Homo sapiens_hsa051331.26143705
26Adherens junction_Homo sapiens_hsa045201.26074017
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23021691
28Choline metabolism in cancer_Homo sapiens_hsa052311.11640797
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10119966
30Long-term depression_Homo sapiens_hsa047301.05463829
31Dilated cardiomyopathy_Homo sapiens_hsa054141.04375207
32Tight junction_Homo sapiens_hsa045301.02721871
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02453726
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01992185
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.01485310
36PPAR signaling pathway_Homo sapiens_hsa033201.01125286
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.99882741
38Sphingolipid metabolism_Homo sapiens_hsa006000.97575265
39Axon guidance_Homo sapiens_hsa043600.96880290
40Circadian rhythm_Homo sapiens_hsa047100.96608754
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96099479
42Dorso-ventral axis formation_Homo sapiens_hsa043200.94828372
43Platelet activation_Homo sapiens_hsa046110.93066651
44Serotonergic synapse_Homo sapiens_hsa047260.92342968
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92064692
46Glioma_Homo sapiens_hsa052140.91152338
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91152303
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.89037821
49Thyroid cancer_Homo sapiens_hsa052160.87251874
50Basal cell carcinoma_Homo sapiens_hsa052170.87198350
51Insulin resistance_Homo sapiens_hsa049310.86683617
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86050397
53Small cell lung cancer_Homo sapiens_hsa052220.82219556
54Phototransduction_Homo sapiens_hsa047440.81426434
55Hippo signaling pathway_Homo sapiens_hsa043900.78656306
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.77847942
57Sphingolipid signaling pathway_Homo sapiens_hsa040710.76708312
58Protein digestion and absorption_Homo sapiens_hsa049740.76089771
59Nitrogen metabolism_Homo sapiens_hsa009100.75957367
60Melanogenesis_Homo sapiens_hsa049160.75233321
61Malaria_Homo sapiens_hsa051440.75087127
62Salmonella infection_Homo sapiens_hsa051320.74589093
63Estrogen signaling pathway_Homo sapiens_hsa049150.74002446
64Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73759202
65Inositol phosphate metabolism_Homo sapiens_hsa005620.72912095
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72160600
67Hepatitis C_Homo sapiens_hsa051600.70996408
68MicroRNAs in cancer_Homo sapiens_hsa052060.70988252
69Ras signaling pathway_Homo sapiens_hsa040140.70852540
70Tyrosine metabolism_Homo sapiens_hsa003500.70465924
71TNF signaling pathway_Homo sapiens_hsa046680.70058853
72HIF-1 signaling pathway_Homo sapiens_hsa040660.69728252
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.68642269
74Tuberculosis_Homo sapiens_hsa051520.68469194
75Pancreatic secretion_Homo sapiens_hsa049720.67861496
76Renal cell carcinoma_Homo sapiens_hsa052110.67348017
77Oxytocin signaling pathway_Homo sapiens_hsa049210.66477966
78Insulin signaling pathway_Homo sapiens_hsa049100.65231024
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63786465
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63294594
81Shigellosis_Homo sapiens_hsa051310.62879073
82NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62428313
83Gastric acid secretion_Homo sapiens_hsa049710.61174955
84Pancreatic cancer_Homo sapiens_hsa052120.60931164
85Renin secretion_Homo sapiens_hsa049240.60874002
86Endocytosis_Homo sapiens_hsa041440.59214015
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59159787
88Pathways in cancer_Homo sapiens_hsa052000.59000989
89Osteoclast differentiation_Homo sapiens_hsa043800.58098382
90Galactose metabolism_Homo sapiens_hsa000520.57935461
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.57836653
92beta-Alanine metabolism_Homo sapiens_hsa004100.56104641
93Fructose and mannose metabolism_Homo sapiens_hsa000510.55736591
94p53 signaling pathway_Homo sapiens_hsa041150.55599888
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53546820
96Rap1 signaling pathway_Homo sapiens_hsa040150.53327356
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52788729
98Chronic myeloid leukemia_Homo sapiens_hsa052200.52781086
99Hedgehog signaling pathway_Homo sapiens_hsa043400.51756072
100Apoptosis_Homo sapiens_hsa042100.51172906
101Antigen processing and presentation_Homo sapiens_hsa046120.49345250
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.48714125
103ErbB signaling pathway_Homo sapiens_hsa040120.48320480
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48262739
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48027446
106Leishmaniasis_Homo sapiens_hsa051400.48005960
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47820080
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47440854
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.47250694
110Salivary secretion_Homo sapiens_hsa049700.47124128
111Gap junction_Homo sapiens_hsa045400.47086559
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47038462
113MAPK signaling pathway_Homo sapiens_hsa040100.46401776
114Phagosome_Homo sapiens_hsa041450.46298441
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46149944
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.45866405
117Long-term potentiation_Homo sapiens_hsa047200.45232703
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45051472
119Notch signaling pathway_Homo sapiens_hsa043300.44725741
120Influenza A_Homo sapiens_hsa051640.44404888
121Prion diseases_Homo sapiens_hsa050200.43778699
122Glutamatergic synapse_Homo sapiens_hsa047240.40869100
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40306623
124ABC transporters_Homo sapiens_hsa020100.38936432
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38717406
126Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35136086
127Glycerolipid metabolism_Homo sapiens_hsa005610.32170945
128Endometrial cancer_Homo sapiens_hsa052130.30942231

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »