ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chemical homeostasis within a tissue (GO:0048875)	8.16779673
2	proline metabolic process (GO:0006560)	6.72464191
3	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	6.52758071
4	phosphate ion transport (GO:0006817)	6.29437006
5	negative regulation of cell fate commitment (GO:0010454)	6.27905566
6	4-hydroxyproline metabolic process (GO:0019471)	6.18306378
7	cilium or flagellum-dependent cell motility (GO:0001539)	5.49833494
8	phosphate ion transmembrane transport (GO:0035435)	5.45617774
9	peptidyl-tyrosine autophosphorylation (GO:0038083)	5.38358156
10	ncRNA 3-end processing (GO:0043628)	5.38180466
11	mating behavior (GO:0007617)	5.22001416
12	intestinal epithelial cell development (GO:0060576)	5.19848756
13	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.03383740
14	keratinocyte proliferation (GO:0043616)	4.84881100
15	negative regulation of cell fate specification (GO:0009996)	4.70990923
16	regulation of hippo signaling (GO:0035330)	4.67673066
17	cellular modified amino acid catabolic process (GO:0042219)	4.66913572
18	cell migration involved in gastrulation (GO:0042074)	4.51721845
19	desmosome organization (GO:0002934)	4.47582509
20	keratinization (GO:0031424)	4.40988703
21	histone H2A acetylation (GO:0043968)	4.39857602
22	regulation of mesoderm development (GO:2000380)	4.30085950
23	hemidesmosome assembly (GO:0031581)	4.27810339
24	keratinocyte differentiation (GO:0030216)	4.19152170
25	establishment of skin barrier (GO:0061436)	4.12560812
26	pentose metabolic process (GO:0019321)	4.06308910
27	multicellular organismal water homeostasis (GO:0050891)	4.04948578
28	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03625132
29	motile cilium assembly (GO:0044458)	3.98879489
30	trophoblast giant cell differentiation (GO:0060707)	3.96879756
31	renal system development (GO:0072001)	3.96784050
32	urate metabolic process (GO:0046415)	3.89406639
33	regulation of water loss via skin (GO:0033561)	3.86666019
34	embryonic foregut morphogenesis (GO:0048617)	3.75083140
35	regulation of vitamin metabolic process (GO:0030656)	3.72167653
36	phosphate ion homeostasis (GO:0055062)	3.68959634
37	trivalent inorganic anion homeostasis (GO:0072506)	3.68959634
38	peptide cross-linking (GO:0018149)	3.66636775
39	regulation of transcription involved in cell fate commitment (GO:0060850)	3.57643124
40	water homeostasis (GO:0030104)	3.56749450
41	epidermal cell differentiation (GO:0009913)	3.55837060
42	cilium movement (GO:0003341)	3.55121711
43	rRNA methylation (GO:0031167)	3.54389965
44	hair cycle (GO:0042633)	3.50441164
45	molting cycle (GO:0042303)	3.50441164
46	multicellular organism reproduction (GO:0032504)	3.45601783
47	axonemal dynein complex assembly (GO:0070286)	3.45205928
48	negative regulation of inclusion body assembly (GO:0090084)	3.41512223
49	regulation of vitamin D biosynthetic process (GO:0060556)	3.40517096
50	viral protein processing (GO:0019082)	3.33323775
51	ribosomal small subunit biogenesis (GO:0042274)	3.31158314
52	glutamine family amino acid catabolic process (GO:0009065)	3.30823274
53	negative regulation of protein localization to cell surface (GO:2000009)	3.24630036
54	left/right pattern formation (GO:0060972)	3.23549431
55	fusion of sperm to egg plasma membrane (GO:0007342)	3.22017695
56	blastocyst development (GO:0001824)	3.21138056
57	lung secretory cell differentiation (GO:0061140)	3.19057375
58	bone remodeling (GO:0046849)	3.14630665
59	tRNA methylation (GO:0030488)	3.12938738
60	sensory perception of taste (GO:0050909)	3.09302676
61	rRNA modification (GO:0000154)	3.08276980
62	lung vasculature development (GO:0060426)	3.05125929
63	axoneme assembly (GO:0035082)	3.04658293
64	embryonic heart tube development (GO:0035050)	2.99569822
65	ribosomal small subunit assembly (GO:0000028)	2.98217810
66	activation of Rac GTPase activity (GO:0032863)	2.94941059
67	mRNA transcription from RNA polymerase II promoter (GO:0042789)	2.92651693
68	regulation of G0 to G1 transition (GO:0070316)	2.92028349
69	tight junction assembly (GO:0070830)	2.89849249
70	retinal cone cell development (GO:0046549)	2.88463648
71	regulation of glomerular filtration (GO:0003093)	2.86715941
72	renal system process involved in regulation of blood volume (GO:0001977)	2.84874160
73	response to mercury ion (GO:0046689)	2.84848742
74	retinal rod cell development (GO:0046548)	2.83163042
75	positive regulation of hair follicle development (GO:0051798)	2.79928190
76	positive regulation of hair cycle (GO:0042635)	2.79928190
77	aminoglycoside antibiotic metabolic process (GO:0030647)	2.78975080
78	regulation of cell fate commitment (GO:0010453)	2.78154410
79	histone H4-K12 acetylation (GO:0043983)	2.76627569
80	positive regulation of action potential (GO:0045760)	2.75889548
81	sodium ion homeostasis (GO:0055078)	2.73463336
82	establishment of tissue polarity (GO:0007164)	2.72274869
83	establishment of planar polarity (GO:0001736)	2.72274869
84	cell differentiation involved in embryonic placenta development (GO:0060706)	2.71066806
85	positive regulation of epidermis development (GO:0045684)	2.68745174
86	mRNA transcription (GO:0009299)	2.65961677
87	nodal signaling pathway (GO:0038092)	2.65795270
88	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	2.65388840
89	digestive tract morphogenesis (GO:0048546)	2.63172538
90	epidermis development (GO:0008544)	2.62904797
91	tachykinin receptor signaling pathway (GO:0007217)	2.60726166
92	sphingomyelin metabolic process (GO:0006684)	2.59902277
93	Notch signaling involved in heart development (GO:0061314)	2.59471869
94	O-glycan processing (GO:0016266)	2.58644776
95	fat-soluble vitamin biosynthetic process (GO:0042362)	2.56115591
96	epithelial cilium movement (GO:0003351)	2.54834652
97	embryonic process involved in female pregnancy (GO:0060136)	2.54676680
98	muscle cell migration (GO:0014812)	2.53510138
99	reproduction (GO:0000003)	2.53103680
100	surfactant homeostasis (GO:0043129)	10.3672752

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TP63_17297297_ChIP-ChIP_HaCaT_Human	6.62608374
2	GATA1_22025678_ChIP-Seq_K562_Human	6.59233756
3	ZNF263_19887448_ChIP-Seq_K562_Human	5.91785068
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.86785992
5	ESR1_21235772_ChIP-Seq_MCF-7_Human	3.72800402
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.68486520
7	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	3.51933501
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.37159405
9	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.72013661
10	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.28966782
11	STAT3_1855785_ChIP-Seq_MESCs_Mouse	2.25053058
12	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.15804594
13	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.12657395
14	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.10899594
15	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.10241722
16	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.96253860
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.86914988
18	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.70961673
19	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.64313429
20	SMC4_20622854_ChIP-Seq_HELA_Human	1.60031905
21	CTCF_27219007_Chip-Seq_Bcells_Human	1.58361107
22	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.53867545
23	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.53867545
24	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.52257560
25	AHR_22903824_ChIP-Seq_MCF-7_Human	1.52005238
26	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.51036290
27	KLF5_25053715_ChIP-Seq_YYC3_Human	1.50431671
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.38202420
29	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.38010243
30	LXR_22292898_ChIP-Seq_THP-1_Human	1.37801884
31	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.37522567
32	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.36753274
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.35760412
34	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.32185493
35	BCOR_27268052_Chip-Seq_Bcells_Human	1.25383600
36	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.24931401
37	TP63_22573176_ChIP-Seq_HFKS_Human	1.24027026
38	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.20284403
39	CTCF_20526341_ChIP-Seq_ESCs_Human	1.19163768
40	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.14660474
41	SPI1_20517297_ChIP-Seq_HL60_Human	1.13544861
42	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.13247829
43	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.12458217
44	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.11485073
45	ATF3_27146783_Chip-Seq_COLON_Human	1.10644299
46	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.09000290
47	SOX2_20726797_ChIP-Seq_SW620_Human	1.08226532
48	BCL6_27268052_Chip-Seq_Bcells_Human	1.07430502
49	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.05582760
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.04534611
51	GATA4_25053715_ChIP-Seq_YYC3_Human	1.03469250
52	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.01907022
53	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.01330100
54	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.00658145
55	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99894059
56	CJUN_26792858_Chip-Seq_BT549_Human	0.99702262
57	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	0.99626120
58	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.98791914
59	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.97208160
60	TP63_23658742_ChIP-Seq_EP156T_Human	0.96618231
61	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96569154
62	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96320513
63	AR_21572438_ChIP-Seq_LNCaP_Human	0.96086454
64	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.95362112
65	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.95313916
66	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.94686619
67	VDR_22108803_ChIP-Seq_LS180_Human	0.93437301
68	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.92651261
69	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.92396120
70	ELK3_25401928_ChIP-Seq_HUVEC_Human	0.91595017
71	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.90286776
72	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.89211358
73	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.88681117
74	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.88625526
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.88308252
76	ZNF274_21170338_ChIP-Seq_K562_Hela	0.88115206
77	DROSHA_22980978_ChIP-Seq_HELA_Human	0.88011104
78	SA1_27219007_Chip-Seq_Bcells_Human	0.87987755
79	TP53_22127205_ChIP-Seq_IMR90_Human	0.86605166
80	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.86318572
81	E2F1_20622854_ChIP-Seq_HELA_Human	0.85974251
82	GATA6_25053715_ChIP-Seq_YYC3_Human	0.83325740
83	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.83233056
84	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.81645158
85	CSB_26484114_Chip-Seq_FIBROBLAST_Human	0.80848629
86	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.79968055
87	P68_20966046_ChIP-Seq_HELA_Human	0.79169337
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.78940445
89	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.78888516
90	ELF5_23300383_ChIP-Seq_T47D_Human	0.78424999
91	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.77963976
92	STAT1_20625510_ChIP-Seq_HELA_Human	0.76517805
93	PHF8_20622854_ChIP-Seq_HELA_Human	0.75955311
94	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.75133783
95	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.75041081
96	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.73725765
97	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.73365451
98	ERA_21632823_ChIP-Seq_H3396_Human	0.72578929
99	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.72380687
100	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.72309973

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004782_abnormal_surfactant_physiolog	6.76871740
2	MP0010234_abnormal_vibrissa_follicle	4.11517083
3	MP0005377_hearing/vestibular/ear_phenot	4.00284465
4	MP0003878_abnormal_ear_physiology	4.00284465
5	MP0002796_impaired_skin_barrier	3.97576235
6	MP0010678_abnormal_skin_adnexa	3.11498917
7	MP0002098_abnormal_vibrissa_morphology	3.06778516
8	MP0000383_abnormal_hair_follicle	2.99639755
9	MP0000566_synostosis	2.75905720
10	MP0000579_abnormal_nail_morphology	2.66374732
11	MP0000678_abnormal_parathyroid_gland	2.59490888
12	MP0004858_abnormal_nervous_system	2.50325791
13	MP0005501_abnormal_skin_physiology	2.20869338
14	MP0003136_yellow_coat_color	2.01939617
15	MP0003453_abnormal_keratinocyte_physiol	2.00546919
16	MP0000762_abnormal_tongue_morphology	1.88296476
17	MP0001216_abnormal_epidermal_layer	1.86270812
18	MP0002277_abnormal_respiratory_mucosa	1.85710102
19	MP0003315_abnormal_perineum_morphology	1.78610060
20	MP0004019_abnormal_vitamin_homeostasis	1.74922265
21	MP0010771_integument_phenotype	1.67288217
22	MP0001873_stomach_inflammation	1.66768426
23	MP0005083_abnormal_biliary_tract	1.64099974
24	MP0002928_abnormal_bile_duct	1.61430185
25	MP0000467_abnormal_esophagus_morphology	1.59958975
26	MP0008995_early_reproductive_senescence	1.57461262
27	MP0003806_abnormal_nucleotide_metabolis	1.56788901
28	MP0004808_abnormal_hematopoietic_stem	1.56294636
29	MP0000647_abnormal_sebaceous_gland	1.47174587
30	MP0008875_abnormal_xenobiotic_pharmacok	1.45621986
31	MP0009379_abnormal_foot_pigmentation	1.45133707
32	MP0005023_abnormal_wound_healing	1.44712686
33	MP0002060_abnormal_skin_morphology	1.39605198
34	MP0005332_abnormal_amino_acid	1.36271204
35	MP0004272_abnormal_basement_membrane	1.31727618
36	MP0005410_abnormal_fertilization	1.30545386
37	MP0004264_abnormal_extraembryonic_tissu	1.28292347
38	MP0000470_abnormal_stomach_morphology	1.27247679
39	MP0005275_abnormal_skin_tensile	1.21985646
40	MP0003566_abnormal_cell_adhesion	1.21970580
41	MP0002163_abnormal_gland_morphology	1.19449755
42	MP0001851_eye_inflammation	1.18945530
43	MP0004043_abnormal_pH_regulation	1.17621477
44	MP0004133_heterotaxia	1.16792929
45	MP0001958_emphysema	1.16390128
46	MP0001849_ear_inflammation	1.14132666
47	MP0010386_abnormal_urinary_bladder	1.12687763
48	MP0005164_abnormal_response_to	1.12100357
49	MP0005165_increased_susceptibility_to	1.11412055
50	MP0004947_skin_inflammation	1.11121670
51	MP0001545_abnormal_hematopoietic_system	1.09681760
52	MP0005397_hematopoietic_system_phenotyp	1.09681760
53	MP0000537_abnormal_urethra_morphology	1.07709563
54	MP0000750_abnormal_muscle_regeneration	1.04084460
55	MP0003786_premature_aging	1.04038897
56	MP0009333_abnormal_splenocyte_physiolog	0.98730829
57	MP0005409_darkened_coat_color	0.97719445
58	MP0002160_abnormal_reproductive_system	0.96110300
59	MP0003119_abnormal_digestive_system	0.95517662
60	MP0001765_abnormal_ion_homeostasis	0.95514701
61	MP0004215_abnormal_myocardial_fiber	0.95116625
62	MP0001502_abnormal_circadian_rhythm	0.93713172
63	MP0000377_abnormal_hair_follicle	0.90767757
64	MP0003191_abnormal_cellular_cholesterol	0.88351777
65	MP0000427_abnormal_hair_cycle	0.86867501
66	MP0001764_abnormal_homeostasis	0.83603055
67	MP0008004_abnormal_stomach_pH	0.79403912
68	MP0009643_abnormal_urine_homeostasis	0.78843018
69	MP0009840_abnormal_foam_cell	0.78714811
70	MP0003045_fibrosis	0.77750689
71	MP0005623_abnormal_meninges_morphology	0.77317561
72	MP0005551_abnormal_eye_electrophysiolog	0.77064660
73	MP0000367_abnormal_coat/_hair	0.76661686
74	MP0008874_decreased_physiological_sensi	0.75740011
75	MP0002332_abnormal_exercise_endurance	0.73939549
76	MP0003718_maternal_effect	0.73761989
77	MP0005319_abnormal_enzyme/_coenzyme	0.72294589
78	MP0005645_abnormal_hypothalamus_physiol	0.71538109
79	MP0005187_abnormal_penis_morphology	0.71510053
80	MP0004957_abnormal_blastocyst_morpholog	0.71280812
81	MP0005388_respiratory_system_phenotype	0.70859929
82	MP0002133_abnormal_respiratory_system	0.70859929
83	MP0005253_abnormal_eye_physiology	0.70724543
84	MP0001485_abnormal_pinna_reflex	0.66926554
85	MP0003950_abnormal_plasma_membrane	0.66741764
86	MP0003959_abnormal_lean_body	0.66597395
87	MP0003943_abnormal_hepatobiliary_system	0.65884592
88	MP0002653_abnormal_ependyma_morphology	0.64164854
89	MP0005085_abnormal_gallbladder_physiolo	0.63850208
90	MP0000627_abnormal_mammary_gland	0.62174754
91	MP0004085_abnormal_heartbeat	0.60413959
92	MP0001905_abnormal_dopamine_level	0.58638128
93	MP0001730_embryonic_growth_arrest	0.57142133
94	MP0008775_abnormal_heart_ventricle	0.56540926
95	MP0005376_homeostasis/metabolism_phenot	0.56441329
96	MP0002733_abnormal_thermal_nociception	0.56010460
97	MP0001177_atelectasis	0.55277572
98	MP0010352_gastrointestinal_tract_polyps	0.54597281
99	MP0005381_digestive/alimentary_phenotyp	0.54016827
100	MP0005195_abnormal_posterior_eye	0.53623670

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hydroxyprolinuria (HP:0003080)	6.21845730
2	Abnormality of proline metabolism (HP:0010907)	6.21845730
3	Interstitial pulmonary disease (HP:0006530)	5.52390227
4	Absent/shortened dynein arms (HP:0200106)	4.78768665
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.78768665
6	Oral leukoplakia (HP:0002745)	4.63266970
7	Abnormality of nail color (HP:0100643)	4.53621974
8	Alopecia of scalp (HP:0002293)	4.48024871
9	Generalized aminoaciduria (HP:0002909)	4.43588511
10	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.06446540
11	Plantar hyperkeratosis (HP:0007556)	4.01596808
12	Palmoplantar hyperkeratosis (HP:0000972)	3.99497367
13	Thick nail (HP:0001805)	3.85327389
14	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.80341431
15	Palmar hyperkeratosis (HP:0010765)	3.70202256
16	Abnormal ciliary motility (HP:0012262)	3.70191496
17	Pendular nystagmus (HP:0012043)	3.67020485
18	Abnormality of the dental pulp (HP:0006479)	3.61870710
19	Hyperglycinuria (HP:0003108)	3.58741122
20	Chronic bronchitis (HP:0004469)	3.49970202
21	Sparse eyelashes (HP:0000653)	3.28894079
22	Popliteal pterygium (HP:0009756)	3.27968155
23	Hyperactive renin-angiotensin system (HP:0000841)	3.27806148
24	Onycholysis (HP:0001806)	3.23764752
25	Right ventricular cardiomyopathy (HP:0011663)	3.22351586
26	Abnormal respiratory epithelium morphology (HP:0012253)	3.16514950
27	Abnormal respiratory motile cilium morphology (HP:0005938)	3.16514950
28	Hydroureter (HP:0000072)	3.13159543
29	Abnormality of the dental root (HP:0006486)	3.02936075
30	Taurodontia (HP:0000679)	3.02936075
31	Abnormality of permanent molar morphology (HP:0011071)	3.02936075
32	Status epilepticus (HP:0002133)	3.01440099
33	Hyperkalemia (HP:0002153)	3.00918724
34	Abnormal respiratory motile cilium physiology (HP:0012261)	2.98448046
35	Cone-rod dystrophy (HP:0000548)	2.96559160
36	Abnormality of placental membranes (HP:0011409)	2.81519915
37	Amniotic constriction ring (HP:0009775)	2.81519915
38	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.77082056
39	Abnormality of molar (HP:0011077)	2.74765687
40	Abnormality of molar morphology (HP:0011070)	2.74765687
41	Nail dystrophy (HP:0008404)	2.67841592
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.59448068
43	Oligodontia (HP:0000677)	2.59097188
44	Fragile nails (HP:0001808)	2.58316928
45	Bell-shaped thorax (HP:0001591)	2.53652196
46	Intrahepatic cholestasis (HP:0001406)	2.51156041
47	Hypotrichosis (HP:0001006)	2.45433514
48	Chronic hepatic failure (HP:0100626)	2.45317850
49	Amelogenesis imperfecta (HP:0000705)	2.44475437
50	Corneal erosion (HP:0200020)	2.43920276
51	Respiratory distress (HP:0002098)	2.42956407
52	Proximal tubulopathy (HP:0000114)	2.41903018
53	Erythema (HP:0010783)	2.41374370
54	Milia (HP:0001056)	2.39037574
55	Nasal polyposis (HP:0100582)	2.38503464
56	Severe visual impairment (HP:0001141)	2.34098184
57	Furrowed tongue (HP:0000221)	2.33036252
58	Polar cataract (HP:0010696)	2.32934958
59	Abnormality of serine family amino acid metabolism (HP:0010894)	2.32395009
60	Abnormality of glycine metabolism (HP:0010895)	2.32395009
61	Renal salt wasting (HP:0000127)	2.30488552
62	Deep venous thrombosis (HP:0002625)	2.26445857
63	Parakeratosis (HP:0001036)	2.24954428
64	Congenital ichthyosiform erythroderma (HP:0007431)	2.22053955
65	Abnormality of the renal collecting system (HP:0004742)	2.19798824
66	Ridged nail (HP:0001807)	2.18827249
67	Focal segmental glomerulosclerosis (HP:0000097)	2.18563438
68	Flat acetabular roof (HP:0003180)	2.18401704
69	Squamous cell carcinoma (HP:0002860)	2.17998159
70	Lip pit (HP:0100267)	2.17941517
71	Split foot (HP:0001839)	2.15933767
72	Tachypnea (HP:0002789)	2.14986121
73	Hypoplastic ischia (HP:0003175)	2.14629088
74	Hypoalphalipoproteinemia (HP:0003233)	2.14153747
75	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.14138434
76	Vertebral hypoplasia (HP:0008417)	2.14138434
77	Tubulointerstitial nephritis (HP:0001970)	2.13904401
78	Bony spicule pigmentary retinopathy (HP:0007737)	2.06650831
79	Abnormality of the nasal mucosa (HP:0000433)	2.01057137
80	Pustule (HP:0200039)	1.99823988
81	Abnormal vertebral ossification (HP:0100569)	1.99061501
82	Pili torti (HP:0003777)	1.98819047
83	Metaphyseal cupping (HP:0003021)	1.98364060
84	Abnormality of the ischium (HP:0003174)	1.97838697
85	Erythroderma (HP:0001019)	1.94840670
86	Progressive hearing impairment (HP:0001730)	1.93044293
87	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.92836677
88	Abnormality of abdominal situs (HP:0011620)	1.90880550
89	Abdominal situs inversus (HP:0003363)	1.90880550
90	Glomerulosclerosis (HP:0000096)	1.90506604
91	Hypohidrosis (HP:0000966)	1.89521278
92	Vertebral clefting (HP:0008428)	1.87489491
93	Pterygium (HP:0001059)	1.87369816
94	Conical tooth (HP:0000698)	1.86795736
95	Rhinitis (HP:0012384)	1.86163795
96	Tubulointerstitial fibrosis (HP:0005576)	1.84906583
97	Duplicated collecting system (HP:0000081)	1.84565623
98	Abnormal blistering of the skin (HP:0008066)	1.84543727
99	Subcapsular cataract (HP:0000523)	1.83853080
100	Male infertility (HP:0003251)	1.79833482

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	8.28497857
2	MST1R	5.95775609
3	LATS2	5.09662807
4	LMTK2	4.36362385
5	MET	2.73598501
6	ERN1	2.37280802
7	IRAK3	2.24706679
8	TESK1	2.11572712
9	IRAK1	2.06129252
10	SIK1	1.83000217
11	MST4	1.76008004
12	ERBB4	1.65677692
13	PHKG2	1.62513269
14	PHKG1	1.62513269
15	NME1	1.49384590
16	MAPK15	1.45870541
17	CDK12	1.44527815
18	PRKG2	1.40884105
19	MAP3K9	1.38875983
20	TRPM7	1.25822785
21	MAP3K3	1.22354258
22	PAK4	1.21820013
23	SMG1	1.20455224
24	STK10	1.09798843
25	CDK19	1.03140446
26	PBK	1.02854823
27	BMX	0.96704409
28	RPS6KB2	0.95770749
29	AURKA	0.95371055
30	ICK	0.93166449
31	FRK	0.91405535
32	PLK4	0.86614790
33	NME2	0.82540606
34	ADRBK2	0.78217447
35	EEF2K	0.77322940
36	TGFBR1	0.76200507
37	RIPK1	0.74244593
38	MAPKAPK3	0.70089228
39	MARK2	0.69921744
40	RPS6KA2	0.69784149
41	YES1	0.59765389
42	AKT2	0.59583006
43	RPS6KL1	0.59477181
44	RPS6KC1	0.59477181
45	JAK3	0.59250709
46	RPS6KA6	0.59192253
47	CDK8	0.58178111
48	DAPK2	0.54637651
49	PTK2	0.53957686
50	DDR2	0.53815609
51	IRAK2	0.53175253
52	MAP3K8	0.50278242
53	MAP3K2	0.49721719
54	BUB1	0.49315453
55	LIMK1	0.48689782
56	EPHB1	0.47911527
57	PDPK1	0.47221380
58	CDK7	0.46584031
59	PRKCI	0.44362889
60	GRK1	0.43845126
61	STK38	0.43571235
62	TESK2	0.43279460
63	CDC42BPA	0.42426709
64	MAP2K6	0.42020071
65	MAP3K7	0.41038763
66	FER	0.40526465
67	TSSK6	0.40392291
68	PAK1	0.39354745
69	PTK2B	0.35925926
70	PRKCD	0.35821251
71	MUSK	0.35190669
72	AURKB	0.35139616
73	RPS6KA1	0.35136763
74	ADRBK1	0.34954574
75	GRK5	0.33825441
76	FGFR4	0.33620740
77	MAP4K1	0.33362819
78	MAPKAPK2	0.33099559
79	RPS6KB1	0.31800769
80	LRRK2	0.31184126
81	BCR	0.31044397
82	CHEK1	0.31019629
83	GSK3A	0.29465033
84	SRC	0.29411713
85	STK11	0.28747645
86	LATS1	0.28693240
87	IKBKB	0.28540063
88	SIK3	0.28058507
89	IGF1R	0.26025651
90	ZAP70	0.25381279
91	WNK4	0.25287034
92	MAP3K13	0.24916135
93	KDR	0.24747058
94	TXK	0.24732315
95	PDGFRB	0.23530022
96	MAP3K1	0.23513458
97	PRKCA	0.22087819
98	PDK1	0.21810237
99	PAK2	0.20968244
100	ERBB2	0.20486757

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.63926770
2	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	3.90437965
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.37108651
4	Folate biosynthesis_Homo sapiens_hsa00790	3.15295573
5	Sulfur relay system_Homo sapiens_hsa04122	3.15094231
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.71537831
7	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.30525952
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.23286592
9	Arginine and proline metabolism_Homo sapiens_hsa00330	2.20469790
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.20445475
11	Ribosome_Homo sapiens_hsa03010	2.17943911
12	Retinol metabolism_Homo sapiens_hsa00830	1.95256096
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.76312356
14	Mineral absorption_Homo sapiens_hsa04978	1.76072449
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.73969736
16	ECM-receptor interaction_Homo sapiens_hsa04512	1.73045613
17	Phototransduction_Homo sapiens_hsa04744	1.71588060
18	ABC transporters_Homo sapiens_hsa02010	1.70619959
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.70362265
20	Taste transduction_Homo sapiens_hsa04742	1.60980208
21	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.57791539
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57297946
23	Sulfur metabolism_Homo sapiens_hsa00920	1.47839994
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35782356
25	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.34987367
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.34945854
27	Notch signaling pathway_Homo sapiens_hsa04330	1.34175365
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.32679512
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.29471328
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20390185
31	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.18351783
32	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.15624197
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.14871419
34	Arginine biosynthesis_Homo sapiens_hsa00220	1.13042261
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.07046158
36	African trypanosomiasis_Homo sapiens_hsa05143	1.05571093
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05379270
38	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.04779560
39	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.04727806
40	Complement and coagulation cascades_Homo sapiens_hsa04610	1.00308831
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.98061905
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.95891112
43	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.93755072
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93476539
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.91623484
46	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.88001676
47	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.86462109
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.86100194
49	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.85723987
50	Adherens junction_Homo sapiens_hsa04520	0.83663318
51	RNA polymerase_Homo sapiens_hsa03020	0.83533517
52	Tight junction_Homo sapiens_hsa04530	0.83033587
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.82087249
54	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80813891
55	Olfactory transduction_Homo sapiens_hsa04740	0.76572782
56	Pentose phosphate pathway_Homo sapiens_hsa00030	0.76460811
57	Nicotine addiction_Homo sapiens_hsa05033	0.73965409
58	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.71789155
59	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68821570
60	Histidine metabolism_Homo sapiens_hsa00340	0.68808118
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.65801168
62	One carbon pool by folate_Homo sapiens_hsa00670	0.65271458
63	Galactose metabolism_Homo sapiens_hsa00052	0.64128034
64	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.58529972
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.57143413
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.55839369
67	Metabolic pathways_Homo sapiens_hsa01100	0.55551873
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.53690978
69	Lysosome_Homo sapiens_hsa04142	0.53311614
70	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.50099596
71	Morphine addiction_Homo sapiens_hsa05032	0.49037041
72	Huntingtons disease_Homo sapiens_hsa05016	0.46127682
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.45762564
74	Caffeine metabolism_Homo sapiens_hsa00232	0.43917822
75	Endocytosis_Homo sapiens_hsa04144	0.43028599
76	Axon guidance_Homo sapiens_hsa04360	0.41865864
77	Bile secretion_Homo sapiens_hsa04976	0.37602106
78	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.36788727
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35614784
80	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.35306241
81	Pertussis_Homo sapiens_hsa05133	0.33316403
82	Prion diseases_Homo sapiens_hsa05020	0.32940555
83	MAPK signaling pathway_Homo sapiens_hsa04010	0.31657382
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.31333998
85	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29928488
86	Salivary secretion_Homo sapiens_hsa04970	0.29757599
87	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.28973133
88	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.28918133
89	Insulin resistance_Homo sapiens_hsa04931	0.28310241
90	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.27959329
91	Glutamatergic synapse_Homo sapiens_hsa04724	0.27201665
92	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26704892
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.26309953
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.26208162
95	Steroid biosynthesis_Homo sapiens_hsa00100	0.23501297
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23080384
97	Insulin signaling pathway_Homo sapiens_hsa04910	0.22484166
98	Glucagon signaling pathway_Homo sapiens_hsa04922	0.22420108
99	Proteoglycans in cancer_Homo sapiens_hsa05205	0.21477695
100	Small cell lung cancer_Homo sapiens_hsa05222	0.21152256

KRT16P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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