KRT16P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.52132761
2motile cilium assembly (GO:0044458)9.18091598
3retinal rod cell development (GO:0046548)9.12235306
4cilium movement (GO:0003341)8.62872602
5axonemal dynein complex assembly (GO:0070286)8.48295584
6retinal cone cell development (GO:0046549)7.94071498
7axoneme assembly (GO:0035082)7.90839707
8epithelial cilium movement (GO:0003351)6.39738040
9regulation of cilium movement (GO:0003352)5.64275170
10desmosome organization (GO:0002934)5.44599723
11hemidesmosome assembly (GO:0031581)5.28007559
12skin morphogenesis (GO:0043589)5.08461259
13ventricular system development (GO:0021591)5.04713680
14intestinal epithelial cell development (GO:0060576)5.02054088
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.88204426
16hepatocyte differentiation (GO:0070365)4.84309396
17dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.69573150
18negative regulation of complement activation (GO:0045916)4.47646450
19O-glycan processing (GO:0016266)4.41431272
20lung secretory cell differentiation (GO:0061140)4.38933956
21multicellular organismal water homeostasis (GO:0050891)4.37589603
22lung vasculature development (GO:0060426)4.35814879
23iron ion import (GO:0097286)4.32620231
24maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.25504404
25keratinocyte proliferation (GO:0043616)4.15608411
26establishment of skin barrier (GO:0061436)4.01564919
27regulation of water loss via skin (GO:0033561)4.00530510
28left/right pattern formation (GO:0060972)3.97845845
29negative regulation of protein activation cascade (GO:2000258)3.96866588
30keratinization (GO:0031424)3.89190076
31protein localization to microtubule (GO:0035372)3.88244534
32regulation of integrin-mediated signaling pathway (GO:2001044)3.87645042
33mating behavior (GO:0007617)3.81369836
34negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.80938327
35muscle cell migration (GO:0014812)3.79980721
36embryonic retina morphogenesis in camera-type eye (GO:0060059)3.72354647
37regulation of transforming growth factor beta2 production (GO:0032909)3.64467704
38water homeostasis (GO:0030104)3.62201351
39peptide cross-linking (GO:0018149)3.51572020
40protein retention in ER lumen (GO:0006621)3.50408349
41microtubule depolymerization (GO:0007019)3.49779112
42peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.47206656
43negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.47127807
44negative regulation of humoral immune response (GO:0002921)3.46936507
45positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.46592673
46regulation of hydrogen peroxide-induced cell death (GO:1903205)3.45146858
47negative regulation of response to reactive oxygen species (GO:1901032)3.42920319
48microtubule bundle formation (GO:0001578)3.41140887
49regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.39738963
50sphingomyelin metabolic process (GO:0006684)3.39605809
51keratinocyte differentiation (GO:0030216)3.38513398
52gap junction assembly (GO:0016264)3.35247733
53regulation of microtubule-based movement (GO:0060632)3.32488547
54positive regulation of osteoblast proliferation (GO:0033690)3.25318976
55endothelial cell chemotaxis (GO:0035767)3.24010001
56regulation of glomerular filtration (GO:0003093)3.21423816
57tRNA methylation (GO:0030488)3.20779189
58regulation of endothelial cell chemotaxis (GO:2001026)3.04212407
59trophoblast giant cell differentiation (GO:0060707)3.01720073
60epithelial cell-cell adhesion (GO:0090136)3.00192405
61protein localization to microtubule cytoskeleton (GO:0072698)2.99406594
62blastocyst development (GO:0001824)2.96245963
63protein O-linked glycosylation (GO:0006493)2.91597437
64semaphorin-plexin signaling pathway (GO:0071526)2.90699858
65photoreceptor cell maintenance (GO:0045494)2.88519195
66interleukin-1-mediated signaling pathway (GO:0070498)2.86697333
67regulation of establishment of planar polarity (GO:0090175)2.84673494
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.84335571
69activation of Rac GTPase activity (GO:0032863)2.83410505
70endothelial cell morphogenesis (GO:0001886)2.81560997
71positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.81211932
72sodium ion homeostasis (GO:0055078)2.79939417
73left/right axis specification (GO:0070986)2.79199178
74mesodermal cell differentiation (GO:0048333)2.76425012
75lung cell differentiation (GO:0060479)2.76071759
76regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.75262392
77cell adhesion mediated by integrin (GO:0033627)2.75026609
78fat-soluble vitamin biosynthetic process (GO:0042362)2.74926022
79establishment of tissue polarity (GO:0007164)2.70095387
80establishment of planar polarity (GO:0001736)2.70095387
81lung epithelial cell differentiation (GO:0060487)2.69732182
82negative regulation of keratinocyte proliferation (GO:0010839)2.69000814
83lung epithelium development (GO:0060428)2.66408735
84hypotonic response (GO:0006971)2.65260481
85negative regulation of fibrinolysis (GO:0051918)2.64382988
86epidermal cell differentiation (GO:0009913)2.62320561
87microtubule-based movement (GO:0007018)2.61340590
88epidermis development (GO:0008544)2.60781536
89respiratory gaseous exchange (GO:0007585)2.58695268
90import into cell (GO:0098657)2.57174370
91brain morphogenesis (GO:0048854)2.55318665
92tight junction assembly (GO:0070830)2.53511595
93columnar/cuboidal epithelial cell development (GO:0002066)2.52917679
94lateral ventricle development (GO:0021670)2.52893725
95bone remodeling (GO:0046849)2.52605199
96phosphate ion homeostasis (GO:0055062)2.52234161
97trivalent inorganic anion homeostasis (GO:0072506)2.52234161
98cilium or flagellum-dependent cell motility (GO:0001539)13.4383616
99surfactant homeostasis (GO:0043129)12.9148152
100chemical homeostasis within a tissue (GO:0048875)10.3220322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.34685718
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.42296209
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.22850488
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.71135949
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.52629781
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.09792748
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.95124578
8AR_21572438_ChIP-Seq_LNCaP_Human2.73083465
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.70259761
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.70259761
11CDX2_20551321_ChIP-Seq_CACO-2_Human2.69909642
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.63422823
13ZNF217_24962896_ChIP-Seq_MCF-7_Human2.59700177
14ZNF263_19887448_ChIP-Seq_K562_Human2.57183291
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.55130114
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.54448310
17PPAR_26484153_Chip-Seq_NCI-H1993_Human2.53634701
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human2.44239391
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.43022087
20FOXM1_26456572_ChIP-Seq_MCF-7_Human2.37750481
21AHR_22903824_ChIP-Seq_MCF-7_Human2.26082806
22KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.20596881
23FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human2.19382090
24SOX2_27498859_Chip-Seq_STOMACH_Mouse2.11464955
25P63_26484246_Chip-Seq_KERATINOCYTES_Human2.05682283
26SOX2_20726797_ChIP-Seq_SW620_Human2.03877233
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.99709869
28FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.96677214
29GATA4_25053715_ChIP-Seq_YYC3_Human1.89675569
30SOX9_24532713_ChIP-Seq_HFSC_Mouse1.83191557
31ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.82492121
32CJUN_26792858_Chip-Seq_BT549_Human1.82401316
33AR_21909140_ChIP-Seq_LNCAP_Human1.80834412
34ARNT_22903824_ChIP-Seq_MCF-7_Human1.80805973
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80413333
36GATA6_25053715_ChIP-Seq_YYC3_Human1.71237393
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70527581
38KLF5_25053715_ChIP-Seq_YYC3_Human1.70270134
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70029575
40RACK7_27058665_Chip-Seq_MCF-7_Human1.65301503
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57381260
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.55416921
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53905701
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.52954387
45FOXM1_23109430_ChIP-Seq_U2OS_Human1.50929255
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.49323791
47ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.45552673
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37687572
49FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36963842
50TP63_23658742_ChIP-Seq_EP156T_Human1.36353785
51GATA3_24758297_ChIP-Seq_MCF-7_Human1.35763226
52ATF3_27146783_Chip-Seq_COLON_Human1.30541824
53CLOCK_20551151_ChIP-Seq_293T_Human1.30235758
54AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29405871
55SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26839102
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24173609
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.22780857
58ELK4_26923725_Chip-Seq_MESODERM_Mouse1.20658458
59JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20489983
60HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20330301
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19469966
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.18440182
63EP300_21415370_ChIP-Seq_HL-1_Mouse1.16334942
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.13151137
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.08777589
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.08777589
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08137847
68SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07221629
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06215059
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01815691
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01450394
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00538892
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99172518
74FOXA1_25552417_ChIP-Seq_VCAP_Human0.97788477
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97588871
76* TP63_22573176_ChIP-Seq_HFKS_Human0.96631349
77STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95804471
78TRIM28_21343339_ChIP-Seq_HEK293_Human0.95580954
79P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93015185
80ELF5_23300383_ChIP-Seq_T47D_Human0.91574173
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90281126
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89972846
83ELK3_25401928_ChIP-Seq_HUVEC_Human0.88333957
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87158858
85UBF1/2_26484160_Chip-Seq_HMECs_Human0.85818404
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84218789
87CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81667928
88ERG_20517297_ChIP-Seq_VCAP_Human0.81088300
89UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77875679
90TP53_18474530_ChIP-ChIP_U2OS_Human0.77336661
91LXR_22292898_ChIP-Seq_THP-1_Human0.75737277
92TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74423650
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.72734251
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69728037
95PIAS1_25552417_ChIP-Seq_VCAP_Human0.69451845
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.68071707
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.64919488
98LXR_22158963_ChIP-Seq_LIVER_Mouse0.63386019
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.63076079
100SMAD4_21799915_ChIP-Seq_A2780_Human0.62810957

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog7.47402400
2MP0005083_abnormal_biliary_tract4.57507121
3MP0010234_abnormal_vibrissa_follicle3.95499171
4MP0000566_synostosis3.91168664
5MP0002796_impaired_skin_barrier3.55623380
6MP0010678_abnormal_skin_adnexa3.25321306
7MP0000383_abnormal_hair_follicle3.03294079
8MP0002877_abnormal_melanocyte_morpholog2.60273672
9MP0003566_abnormal_cell_adhesion2.48426075
10MP0000579_abnormal_nail_morphology2.35774325
11MP0005164_abnormal_response_to2.25212731
12MP0008995_early_reproductive_senescence2.23572388
13MP0005023_abnormal_wound_healing2.23095819
14MP0001958_emphysema2.09217707
15MP0003453_abnormal_keratinocyte_physiol2.06326035
16MP0005623_abnormal_meninges_morphology2.05900583
17MP0005501_abnormal_skin_physiology2.05422733
18MP0001216_abnormal_epidermal_layer1.93751922
19MP0002060_abnormal_skin_morphology1.85412246
20MP0010352_gastrointestinal_tract_polyps1.85301876
21MP0001177_atelectasis1.84142895
22MP0003950_abnormal_plasma_membrane1.83599880
23MP0003806_abnormal_nucleotide_metabolis1.79003128
24MP0002133_abnormal_respiratory_system1.77741427
25MP0005388_respiratory_system_phenotype1.77741427
26MP0001346_abnormal_lacrimal_gland1.74165299
27MP0004272_abnormal_basement_membrane1.74046131
28MP0005165_increased_susceptibility_to1.65964798
29MP0010771_integument_phenotype1.63562710
30MP0001851_eye_inflammation1.55323014
31MP0010368_abnormal_lymphatic_system1.54583959
32MP0001873_stomach_inflammation1.53961130
33MP0000762_abnormal_tongue_morphology1.48893994
34MP0004264_abnormal_extraembryonic_tissu1.47894907
35MP0002653_abnormal_ependyma_morphology1.42526654
36MP0003191_abnormal_cellular_cholesterol1.42306407
37MP0002282_abnormal_trachea_morphology1.37796219
38MP0002098_abnormal_vibrissa_morphology1.36969856
39MP0004947_skin_inflammation1.36198909
40MP0000678_abnormal_parathyroid_gland1.33897480
41MP0005275_abnormal_skin_tensile1.33883904
42MP0000751_myopathy1.29493480
43MP0000467_abnormal_esophagus_morphology1.26985590
44MP0003878_abnormal_ear_physiology1.22976297
45MP0005377_hearing/vestibular/ear_phenot1.22976297
46MP0000377_abnormal_hair_follicle1.17880479
47MP0003786_premature_aging1.15453224
48MP0001879_abnormal_lymphatic_vessel1.13240359
49MP0005076_abnormal_cell_differentiation1.10914071
50MP0005253_abnormal_eye_physiology1.07951664
51MP0009840_abnormal_foam_cell1.07030885
52MP0008004_abnormal_stomach_pH1.04825218
53MP0000537_abnormal_urethra_morphology1.03152512
54MP0003091_abnormal_cell_migration1.03141829
55MP0002277_abnormal_respiratory_mucosa1.02731676
56MP0008875_abnormal_xenobiotic_pharmacok0.95159868
57MP0001849_ear_inflammation0.91058351
58MP0000750_abnormal_muscle_regeneration0.89522113
59MP0010030_abnormal_orbit_morphology0.89179221
60MP0003045_fibrosis0.89167328
61MP0005409_darkened_coat_color0.87942898
62MP0001191_abnormal_skin_condition0.87606428
63MP0001175_abnormal_lung_morphology0.85132326
64MP0002295_abnormal_pulmonary_circulatio0.84939085
65MP0005085_abnormal_gallbladder_physiolo0.84824252
66MP0003115_abnormal_respiratory_system0.83640422
67MP0005197_abnormal_uvea_morphology0.81739116
68MP0000627_abnormal_mammary_gland0.80032400
69MP0003705_abnormal_hypodermis_morpholog0.79279338
70MP0000647_abnormal_sebaceous_gland0.78632424
71MP0000733_abnormal_muscle_development0.78192181
72MP0000343_altered_response_to0.75287619
73MP0000367_abnormal_coat/_hair0.75056584
74MP0003638_abnormal_response/metabolism_0.74826675
75MP0000858_altered_metastatic_potential0.71763879
76MP0005376_homeostasis/metabolism_phenot0.70603965
77MP0003315_abnormal_perineum_morphology0.69620706
78MP0005410_abnormal_fertilization0.69489090
79MP0002405_respiratory_system_inflammati0.69146593
80MP0003075_altered_response_to0.69083170
81MP0004858_abnormal_nervous_system0.68759540
82MP0009931_abnormal_skin_appearance0.67868622
83MP0009643_abnormal_urine_homeostasis0.67767919
84MP0002136_abnormal_kidney_physiology0.64746606
85MP0001661_extended_life_span0.63995875
86MP0003436_decreased_susceptibility_to0.60949122
87MP0001542_abnormal_bone_strength0.60096507
88MP0001765_abnormal_ion_homeostasis0.59411461
89MP0004957_abnormal_blastocyst_morpholog0.59338448
90MP0001340_abnormal_eyelid_morphology0.58329073
91MP0009697_abnormal_copulation0.57653003
92MP0002168_other_aberrant_phenotype0.57481567
93MP0002925_abnormal_cardiovascular_devel0.56608536
94MP0002970_abnormal_white_adipose0.55396809
95MP0004043_abnormal_pH_regulation0.55195391
96MP0000427_abnormal_hair_cycle0.54500770
97MP0002118_abnormal_lipid_homeostasis0.53567241
98MP0008873_increased_physiological_sensi0.53415227
99MP0001502_abnormal_circadian_rhythm0.51917044
100MP0009115_abnormal_fat_cell0.50322498

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)7.46946545
2Abnormal ciliary motility (HP:0012262)7.23661011
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.60309716
4Absent rod-and cone-mediated responses on ERG (HP:0007688)6.54681667
5Abnormal respiratory motile cilium morphology (HP:0005938)6.39531323
6Abnormal respiratory epithelium morphology (HP:0012253)6.39531323
7Abnormal respiratory motile cilium physiology (HP:0012261)6.22902781
8Chronic bronchitis (HP:0004469)6.05566224
9Tubulointerstitial nephritis (HP:0001970)6.00289971
10Nasal polyposis (HP:0100582)4.29047413
11Hyperactive renin-angiotensin system (HP:0000841)4.25096918
12Rhinitis (HP:0012384)3.91761518
13Bronchiectasis (HP:0002110)3.86785116
14Bronchitis (HP:0012387)3.76629067
15Abnormality of the nasal mucosa (HP:0000433)3.75246360
16Chronic hepatic failure (HP:0100626)3.71048340
17Thick nail (HP:0001805)3.67359788
18Abnormal rod and cone electroretinograms (HP:0008323)3.64158786
19Progressive sensorineural hearing impairment (HP:0000408)3.60957366
20Cone-rod dystrophy (HP:0000548)3.53541592
21Abnormality of nail color (HP:0100643)3.53435073
22Abnormality of the fingertips (HP:0001211)3.45786833
23Deep venous thrombosis (HP:0002625)3.43640538
24Hypoalphalipoproteinemia (HP:0003233)3.26478250
25Renal salt wasting (HP:0000127)3.13599979
26Subcapsular cataract (HP:0000523)3.07782034
27Alopecia of scalp (HP:0002293)3.07545112
28Right ventricular cardiomyopathy (HP:0011663)3.06754298
29Bony spicule pigmentary retinopathy (HP:0007737)3.04421082
30Short nail (HP:0001799)2.97017852
31Onycholysis (HP:0001806)2.90446627
32Plantar hyperkeratosis (HP:0007556)2.86139914
33Tubulointerstitial abnormality (HP:0001969)2.82085976
34Menstrual irregularities (HP:0000858)2.81326813
35Hyperkalemia (HP:0002153)2.79344370
36Palmoplantar hyperkeratosis (HP:0000972)2.76642437
37Progressive hearing impairment (HP:0001730)2.67236163
38Respiratory distress (HP:0002098)2.66761184
39Subacute progressive viral hepatitis (HP:0006572)2.58497495
40Palmar hyperkeratosis (HP:0010765)2.57386089
41Hyperuricemia (HP:0002149)2.55673954
42Increased purine levels (HP:0004368)2.55673954
43Polar cataract (HP:0010696)2.53240632
44Recurrent otitis media (HP:0000403)2.51283466
45Constricted visual fields (HP:0001133)2.47634768
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.45981699
47Osteolytic defects of the hand bones (HP:0009699)2.45981699
48Pili torti (HP:0003777)2.38635248
49Gout (HP:0001997)2.32435856
50Macroorchidism (HP:0000053)2.25066187
51Tachypnea (HP:0002789)2.24728083
52Tubulointerstitial fibrosis (HP:0005576)2.19685007
53Recurrent bronchitis (HP:0002837)2.19234771
54Glomerulosclerosis (HP:0000096)2.18028829
55Renovascular hypertension (HP:0100817)2.16868232
56Sparse eyelashes (HP:0000653)2.13298656
57Selective tooth agenesis (HP:0001592)2.09036053
58Nail dystrophy (HP:0008404)2.05989564
59Insulin-resistant diabetes mellitus (HP:0000831)2.05595071
60Chronic sinusitis (HP:0011109)2.02583627
61Absent/shortened dynein arms (HP:0200106)10.2326181
62Dynein arm defect of respiratory motile cilia (HP:0012255)10.2326181
63Abnormality of the dental pulp (HP:0006479)1.96834914
64Hyperaldosteronism (HP:0000859)1.96233557
65Aortic aneurysm (HP:0004942)1.95402439
66Recurrent sinusitis (HP:0011108)1.91296361
67Oral leukoplakia (HP:0002745)1.88333501
68Hepatitis (HP:0012115)1.88119655
69Abnormality of chloride homeostasis (HP:0011422)1.86373474
70Focal segmental glomerulosclerosis (HP:0000097)1.85827922
71Infertility (HP:0000789)1.85813691
72Milia (HP:0001056)1.84789172
73Abnormal hair laboratory examination (HP:0003328)1.82416122
74Congenital ichthyosiform erythroderma (HP:0007431)1.81646957
75Ridged nail (HP:0001807)1.79719260
76Decreased circulating renin level (HP:0003351)1.74197273
77Abnormal hair whorl (HP:0010721)1.73795870
78Micronodular cirrhosis (HP:0001413)1.73578272
79Acanthosis nigricans (HP:0000956)1.71591418
80Gingivitis (HP:0000230)1.69658599
81Premature skin wrinkling (HP:0100678)1.67148604
82Abnormality of permanent molar morphology (HP:0011071)1.65741025
83Abnormality of the dental root (HP:0006486)1.65741025
84Taurodontia (HP:0000679)1.65741025
85Abnormal blistering of the skin (HP:0008066)1.64887793
86Male infertility (HP:0003251)1.64615902
87Skin nodule (HP:0200036)1.63219742
88Amelogenesis imperfecta (HP:0000705)1.63060966
89Tubular atrophy (HP:0000092)1.61256690
90Abnormality of renin-angiotensin system (HP:0000847)1.60720095
91Abnormality of purine metabolism (HP:0004352)1.59750198
92Vascular calcification (HP:0004934)1.58722274
93Woolly hair (HP:0002224)1.57364124
94Blepharitis (HP:0000498)1.57286904
95Erythema (HP:0010783)1.56746533
96Hyponatremia (HP:0002902)1.56480170
97Portal hypertension (HP:0001409)1.54947466
98Heterotopia (HP:0002282)1.54782664
99Hypoplasia of dental enamel (HP:0006297)1.54174855
100Viral hepatitis (HP:0006562)1.50777689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.64819053
2MET4.73327735
3MST43.30074611
4ERN13.27085966
5MAP3K92.33290863
6CDK122.10451382
7IRAK12.08717521
8MST1R10.5287656
9ERBB41.93225853
10PAK41.73890663
11LATS11.71215301
12IRAK31.62841115
13TESK11.62522667
14SIK11.62187160
15MAPK151.59272174
16LMTK21.43502393
17STK101.42132463
18EPHB11.38560691
19MAP3K131.35246642
20BMX1.29833228
21LATS21.24132131
22TRPM71.14652690
23STK161.10461954
24BCR1.07407469
25CDK81.04495548
26PNCK1.01694158
27IRAK21.00525818
28LIMK10.98208145
29FER0.96842174
30ZAP700.88453908
31PTK20.87926078
32PTK60.87126545
33LRRK20.85157017
34TYK20.83824093
35PRKCI0.74929129
36MAP3K140.74622525
37MARK20.69853380
38YES10.65103059
39MAP3K20.56189926
40NME10.56120375
41ERBB20.54848341
42TGFBR10.54402268
43IRAK40.53174314
44CDC42BPA0.52525793
45TTK0.44811969
46WEE10.44798224
47MAP2K60.44268975
48MAP3K70.42178678
49NTRK10.41839774
50PDGFRB0.40259516
51MAP3K80.40157042
52RPS6KA20.38493133
53MAP3K60.37479898
54STK380.36720017
55MAPKAPK20.36473578
56STK38L0.36366727
57CHUK0.36274326
58EPHB20.35750345
59VRK20.34827332
60RPS6KB20.34398109
61TAOK10.33044797
62WNK10.32586803
63IGF1R0.32369879
64CDK70.30801695
65MAP3K10.29862352
66DMPK0.27110485
67PTK2B0.26882712
68MAP3K30.26024929
69PRKCE0.25894257
70AURKA0.25469513
71MELK0.25244474
72ABL10.25195932
73WNK40.25164709
74STK30.24985993
75ROCK20.24944441
76MTOR0.24878771
77AKT20.24032662
78EGFR0.23030502
79PHKG10.22728727
80PHKG20.22728727
81BUB10.22086484
82MAPKAPK30.20999140
83ADRBK10.19683741
84BLK0.19643330
85PRKCD0.17132510
86PIM20.16929337
87BRD40.16795239
88PDPK10.15406223
89FYN0.15244850
90NME20.14640811
91IKBKB0.14392061
92AURKB0.14240907
93GSK3A0.13343252
94TESK20.13319795
95PRKG20.12579254
96PBK0.12229890
97STK390.11912513
98CSNK1A1L0.11734655
99SRC0.10879606
100CAMK2G0.10676524

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005125.09723513
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.97735052
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.88809303
4Adherens junction_Homo sapiens_hsa045202.77566775
5ECM-receptor interaction_Homo sapiens_hsa045122.72781705
6ABC transporters_Homo sapiens_hsa020102.55997128
7Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.21322980
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.11747299
9Complement and coagulation cascades_Homo sapiens_hsa046102.10471945
10N-Glycan biosynthesis_Homo sapiens_hsa005102.02760006
11Notch signaling pathway_Homo sapiens_hsa043301.93812886
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.88729318
13Pentose phosphate pathway_Homo sapiens_hsa000301.88081958
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79494965
15Sphingolipid metabolism_Homo sapiens_hsa006001.76028014
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71821853
17Biosynthesis of amino acids_Homo sapiens_hsa012301.65427608
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.62046185
19Mineral absorption_Homo sapiens_hsa049781.58416728
20Galactose metabolism_Homo sapiens_hsa000521.50775888
21Small cell lung cancer_Homo sapiens_hsa052221.47203453
22Fructose and mannose metabolism_Homo sapiens_hsa000511.34884817
23Tight junction_Homo sapiens_hsa045301.34686952
24Steroid biosynthesis_Homo sapiens_hsa001001.31995769
25Proteoglycans in cancer_Homo sapiens_hsa052051.31089013
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.30261472
27Lysosome_Homo sapiens_hsa041421.24932837
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22615953
29Bladder cancer_Homo sapiens_hsa052191.21059646
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13040445
31Linoleic acid metabolism_Homo sapiens_hsa005911.12449031
32Ether lipid metabolism_Homo sapiens_hsa005651.11152266
33Arginine biosynthesis_Homo sapiens_hsa002201.09851117
34Histidine metabolism_Homo sapiens_hsa003401.08844311
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.07828312
36Focal adhesion_Homo sapiens_hsa045101.07090537
37Pertussis_Homo sapiens_hsa051331.06056824
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.05689552
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98662726
40Glycerophospholipid metabolism_Homo sapiens_hsa005640.96173317
41Axon guidance_Homo sapiens_hsa043600.93093129
42Vitamin digestion and absorption_Homo sapiens_hsa049770.89818016
43Renal cell carcinoma_Homo sapiens_hsa052110.89727125
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87943233
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.86486953
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86295070
47TNF signaling pathway_Homo sapiens_hsa046680.84636523
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82603033
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79442923
50Retinol metabolism_Homo sapiens_hsa008300.77947182
51Bile secretion_Homo sapiens_hsa049760.77607422
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76855684
53Selenocompound metabolism_Homo sapiens_hsa004500.75754008
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75287115
55Ovarian steroidogenesis_Homo sapiens_hsa049130.74628586
56Huntingtons disease_Homo sapiens_hsa050160.74488701
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74351727
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.74074945
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74022709
60Endocytosis_Homo sapiens_hsa041440.71461630
61Hematopoietic cell lineage_Homo sapiens_hsa046400.70428319
62Amoebiasis_Homo sapiens_hsa051460.70413880
63Antigen processing and presentation_Homo sapiens_hsa046120.68269342
64Dorso-ventral axis formation_Homo sapiens_hsa043200.67430065
65Apoptosis_Homo sapiens_hsa042100.66561489
66Arachidonic acid metabolism_Homo sapiens_hsa005900.66450943
67MicroRNAs in cancer_Homo sapiens_hsa052060.65527667
68ErbB signaling pathway_Homo sapiens_hsa040120.64549482
69Chronic myeloid leukemia_Homo sapiens_hsa052200.64118859
70Dilated cardiomyopathy_Homo sapiens_hsa054140.63376504
71Phagosome_Homo sapiens_hsa041450.61913133
72Phenylalanine metabolism_Homo sapiens_hsa003600.61871722
73Circadian rhythm_Homo sapiens_hsa047100.60491525
74Hippo signaling pathway_Homo sapiens_hsa043900.58308636
75Starch and sucrose metabolism_Homo sapiens_hsa005000.57357123
76Malaria_Homo sapiens_hsa051440.57310448
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55992346
78Hepatitis C_Homo sapiens_hsa051600.54558954
79Toxoplasmosis_Homo sapiens_hsa051450.53566790
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51174855
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.50772447
82Prion diseases_Homo sapiens_hsa050200.50037088
83Nitrogen metabolism_Homo sapiens_hsa009100.48084225
84p53 signaling pathway_Homo sapiens_hsa041150.48040570
85Fatty acid biosynthesis_Homo sapiens_hsa000610.47126976
86VEGF signaling pathway_Homo sapiens_hsa043700.47105854
87Viral myocarditis_Homo sapiens_hsa054160.45233276
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44929148
89Thyroid hormone synthesis_Homo sapiens_hsa049180.42302953
90Pancreatic cancer_Homo sapiens_hsa052120.41338216
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39375275
92Arginine and proline metabolism_Homo sapiens_hsa003300.38945542
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37660953
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37469222
95Shigellosis_Homo sapiens_hsa051310.36973656
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35720835
97Taste transduction_Homo sapiens_hsa047420.35532211
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34837207
99Pancreatic secretion_Homo sapiens_hsa049720.34439772
100Pathways in cancer_Homo sapiens_hsa052000.33819534

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