ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinocyte differentiation (GO:0030216)	8.71445136
2	keratinocyte proliferation (GO:0043616)	8.58756043
3	molting cycle (GO:0042303)	7.95259740
4	hair cycle (GO:0042633)	7.95259740
5	intermediate filament organization (GO:0045109)	7.47526692
6	multicellular organismal water homeostasis (GO:0050891)	6.95248402
7	epidermis development (GO:0008544)	6.92073383
8	epidermal cell differentiation (GO:0009913)	6.82500649
9	peptide cross-linking (GO:0018149)	6.78525839
10	surfactant homeostasis (GO:0043129)	6.51801638
11	negative regulation of keratinocyte proliferation (GO:0010839)	6.04761176
12	intermediate filament cytoskeleton organization (GO:0045104)	5.70020500
13	water homeostasis (GO:0030104)	5.66233569
14	intermediate filament-based process (GO:0045103)	5.48279625
15	gap junction assembly (GO:0016264)	5.43137557
16	cell-substrate junction assembly (GO:0007044)	5.32819463
17	chemical homeostasis within a tissue (GO:0048875)	5.30086070
18	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	5.21348869
19	positive regulation of epidermis development (GO:0045684)	4.85161294
20	ectoderm development (GO:0007398)	4.84396469
21	establishment of tissue polarity (GO:0007164)	4.83229741
22	establishment of planar polarity (GO:0001736)	4.83229741
23	regulation of keratinocyte proliferation (GO:0010837)	4.58442861
24	positive regulation of epidermal cell differentiation (GO:0045606)	4.45856651
25	regulation of hair follicle development (GO:0051797)	4.43097069
26	keratinocyte development (GO:0003334)	4.25963691
27	positive regulation of hair cycle (GO:0042635)	4.21957037
28	positive regulation of hair follicle development (GO:0051798)	4.21957037
29	polarized epithelial cell differentiation (GO:0030859)	4.14317097
30	skin morphogenesis (GO:0043589)	4.02516619
31	negative regulation of cell fate specification (GO:0009996)	4.00536477
32	long-chain fatty acid biosynthetic process (GO:0042759)	3.80978936
33	renal system development (GO:0072001)	3.71115770
34	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.69273117
35	positive regulation of keratinocyte differentiation (GO:0045618)	3.67413189
36	regulation of epidermis development (GO:0045682)	3.66457164
37	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.65841671
38	cell communication involved in cardiac conduction (GO:0086065)	3.57911395
39	epithelial cell differentiation involved in prostate gland development (GO:0060742)	3.57617853
40	regulation of hair cycle (GO:0042634)	3.56839314
41	regulation of keratinocyte differentiation (GO:0045616)	3.53275652
42	epithelium development (GO:0060429)	3.52673468
43	intestinal epithelial cell development (GO:0060576)	3.52582668
44	negative regulation of cell fate commitment (GO:0010454)	3.51988990
45	atrioventricular valve morphogenesis (GO:0003181)	3.50138671
46	skin development (GO:0043588)	3.46273555
47	ventricular cardiac muscle cell action potential (GO:0086005)	3.40782545
48	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.40622042
49	negative regulation of epidermis development (GO:0045683)	3.40268451
50	lateral sprouting from an epithelium (GO:0060601)	3.38233054
51	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	3.35198681
52	negative regulation of interferon-gamma production (GO:0032689)	3.31587855
53	collecting duct development (GO:0072044)	3.30556660
54	detection of bacterium (GO:0016045)	3.24165758
55	hair follicle morphogenesis (GO:0031069)	3.20887014
56	regulation of epidermal cell differentiation (GO:0045604)	3.19048845
57	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.15573309
58	cell adhesion mediated by integrin (GO:0033627)	3.14394662
59	lipoxygenase pathway (GO:0019372)	3.13372772
60	4-hydroxyproline metabolic process (GO:0019471)	3.10834897
61	regulation of mesoderm development (GO:2000380)	3.08586712
62	phosphatidylserine metabolic process (GO:0006658)	3.07278058
63	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	3.03542853
64	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.01512308
65	regulation of heart rate by cardiac conduction (GO:0086091)	3.00426200
66	phosphatidylcholine acyl-chain remodeling (GO:0036151)	3.00409678
67	regulation of T cell chemotaxis (GO:0010819)	2.99000479
68	positive regulation of T cell chemotaxis (GO:0010820)	2.99000479
69	regulation of transforming growth factor beta2 production (GO:0032909)	2.97396680
70	positive regulation of glomerulus development (GO:0090193)	2.90831893
71	morphogenesis of embryonic epithelium (GO:0016331)	2.88975656
72	linoleic acid metabolic process (GO:0043651)	2.88031548
73	sodium ion export (GO:0071436)	2.86890769
74	cell junction assembly (GO:0034329)	2.84418521
75	activation of Rac GTPase activity (GO:0032863)	2.83231734
76	filopodium assembly (GO:0046847)	2.81768400
77	detection of other organism (GO:0098543)	2.78667726
78	cell junction organization (GO:0034330)	2.76720175
79	endosome organization (GO:0007032)	2.75641447
80	endodermal cell differentiation (GO:0035987)	2.74980193
81	molting cycle process (GO:0022404)	2.68837064
82	hair cycle process (GO:0022405)	2.68837064
83	proline metabolic process (GO:0006560)	2.66641171
84	positive regulation of monocyte chemotaxis (GO:0090026)	2.66362450
85	cytoskeletal anchoring at plasma membrane (GO:0007016)	2.63232645
86	regulation of transforming growth factor beta1 production (GO:0032908)	2.61303882
87	cell migration involved in gastrulation (GO:0042074)	2.60202983
88	regulation of endothelial cell chemotaxis (GO:2001026)	2.57863811
89	regulation of G0 to G1 transition (GO:0070316)	2.57005663
90	cell surface receptor signaling pathway involved in heart development (GO:0061311)	2.54249325
91	morphogenesis of an epithelial fold (GO:0060571)	2.53222022
92	regulation of epidermal growth factor-activated receptor activity (GO:0007176)	2.51966576
93	alditol phosphate metabolic process (GO:0052646)	2.49748109
94	cell-cell junction assembly (GO:0007043)	2.49486941
95	keratinization (GO:0031424)	14.7398149
96	hemidesmosome assembly (GO:0031581)	14.1774794
97	desmosome organization (GO:0002934)	13.2982424
98	establishment of skin barrier (GO:0061436)	11.5938507
99	bundle of His cell to Purkinje myocyte communication (GO:0086069)	10.9614631
100	regulation of water loss via skin (GO:0033561)	10.5530811

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	4.83956716
2	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	4.05867024
3	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.49808328
4	ZNF263_19887448_ChIP-Seq_K562_Human	3.37945584
5	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.68893361
6	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.68893361
7	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.63822784
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.60853318
9	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.13255813
10	ESR1_21235772_ChIP-Seq_MCF-7_Human	2.07642945
11	TP63_17297297_ChIP-ChIP_HaCaT_Human	16.1992681
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.99749746
13	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.98368330
14	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.85044079
15	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.82581843
16	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.81017363
17	TP63_23658742_ChIP-Seq_EP156T_Human	1.74157134
18	* TP63_22573176_ChIP-Seq_HFKS_Human	1.71964289
19	RACK7_27058665_Chip-Seq_MCF-7_Human	1.71438051
20	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.69261306
21	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.66805766
22	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.64315320
23	ATF3_27146783_Chip-Seq_COLON_Human	1.50531196
24	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.42553343
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.41588847
26	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.40625664
27	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.36104412
28	KLF5_25053715_ChIP-Seq_YYC3_Human	1.35594127
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.32406371
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.31950631
31	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.28332751
32	SOX2_20726797_ChIP-Seq_SW620_Human	1.27651867
33	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	1.25321247
34	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.23162482
35	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.20854272
36	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.19629586
37	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.18222207
38	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.15654608
39	LXR_22292898_ChIP-Seq_THP-1_Human	1.15629279
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08302953
41	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	1.06321151
42	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.06259029
43	EGR1_19032775_ChIP-ChIP_M12_Human	1.05226273
44	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.04837893
45	SMC4_20622854_ChIP-Seq_HELA_Human	1.04770948
46	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.03359842
47	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.03097638
48	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.01513197
49	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.01096470
50	TRIM28_21343339_ChIP-Seq_HEK293_Human	0.98506238
51	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.97399925
52	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.96502033
53	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.93417550
54	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.92695207
55	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.87355417
56	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.82958246
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.81308217
58	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.80111545
59	BCOR_27268052_Chip-Seq_Bcells_Human	0.79038479
60	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.78931661
61	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.78433155
62	TP53_22127205_ChIP-Seq_IMR90_Human	0.76076958
63	AHR_22903824_ChIP-Seq_MCF-7_Human	0.75872493
64	CJUN_26792858_Chip-Seq_BT549_Human	0.75608663
65	SA1_27219007_Chip-Seq_Bcells_Human	0.75054412
66	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.74633608
67	NACC1_18358816_ChIP-ChIP_MESCs_Mouse	0.73968926
68	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.73829507
69	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.73814860
70	P68_20966046_ChIP-Seq_HELA_Human	0.73430769
71	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.72057423
72	GATA6_25053715_ChIP-Seq_YYC3_Human	0.70988620
73	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.70791983
74	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.70778153
75	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.70356210
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.70137515
77	CTCF_20526341_ChIP-Seq_ESCs_Human	0.69867154
78	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.69496323
79	CREB1_26743006_Chip-Seq_LNCaP_Human	0.69152067
80	GATA4_25053715_ChIP-Seq_YYC3_Human	0.68432202
81	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.68329962
82	E2F1_20622854_ChIP-Seq_HELA_Human	0.68240327
83	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.68075142
84	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.67741995
85	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.67292813
86	TP53_18474530_ChIP-ChIP_U2OS_Human	0.66044892
87	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.63993668
88	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	0.63647308
89	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.63055361
90	RXR_22108803_ChIP-Seq_LS180_Human	0.62610332
91	CLOCK_20551151_ChIP-Seq_293T_Human	0.62596716
92	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.62153912
93	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.61292587
94	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.61218730
95	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.61037478
96	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.60924294
97	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.60755221
98	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.59448561
99	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.58831702
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.58448822

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	8.49865141
2	MP0002796_impaired_skin_barrier	7.00492778
3	MP0010234_abnormal_vibrissa_follicle	5.20978933
4	MP0005275_abnormal_skin_tensile	4.48945390
5	MP0005501_abnormal_skin_physiology	4.03475385
6	MP0003941_abnormal_skin_development	3.57462051
7	MP0000467_abnormal_esophagus_morphology	3.33865327
8	MP0000566_synostosis	3.29355262
9	MP0002098_abnormal_vibrissa_morphology	3.28856636
10	MP0003453_abnormal_keratinocyte_physiol	3.21651407
11	MP0010678_abnormal_skin_adnexa	3.13433113
12	MP0001216_abnormal_epidermal_layer	3.11535724
13	MP0000383_abnormal_hair_follicle	2.94607403
14	MP0004381_abnormal_hair_follicle	2.94423118
15	MP0002060_abnormal_skin_morphology	2.86684126
16	MP0000762_abnormal_tongue_morphology	2.84953093
17	MP0010771_integument_phenotype	2.61023638
18	MP0004264_abnormal_extraembryonic_tissu	2.47590878
19	MP0003566_abnormal_cell_adhesion	2.29798212
20	MP0000377_abnormal_hair_follicle	2.18236240
21	MP0005409_darkened_coat_color	2.17880169
22	MP0003705_abnormal_hypodermis_morpholog	2.15748214
23	MP0004782_abnormal_surfactant_physiolog	2.14622844
24	MP0004885_abnormal_endolymph	2.03600072
25	MP0003191_abnormal_cellular_cholesterol	1.85583472
26	MP0003878_abnormal_ear_physiology	1.82296575
27	MP0005377_hearing/vestibular/ear_phenot	1.82296575
28	MP0009053_abnormal_anal_canal	1.76198510
29	MP0000427_abnormal_hair_cycle	1.72846778
30	MP0000647_abnormal_sebaceous_gland	1.49495952
31	MP0003315_abnormal_perineum_morphology	1.46280918
32	MP0002234_abnormal_pharynx_morphology	1.44668272
33	MP0009931_abnormal_skin_appearance	1.44120386
34	MP0005023_abnormal_wound_healing	1.42870356
35	MP0004947_skin_inflammation	1.38995077
36	MP0004272_abnormal_basement_membrane	1.38831628
37	MP0001849_ear_inflammation	1.28206709
38	MP0000367_abnormal_coat/_hair	1.24731218
39	MP0001191_abnormal_skin_condition	1.09349049
40	MP0000678_abnormal_parathyroid_gland	1.04555438
41	MP0008260_abnormal_autophagy	1.03123360
42	MP0001851_eye_inflammation	1.00999261
43	MP0000537_abnormal_urethra_morphology	0.90368862
44	MP0004043_abnormal_pH_regulation	0.88026576
45	MP0008789_abnormal_olfactory_epithelium	0.83308031
46	MP0000627_abnormal_mammary_gland	0.82262965
47	MP0004185_abnormal_adipocyte_glucose	0.81408725
48	MP0003755_abnormal_palate_morphology	0.70833027
49	MP0003950_abnormal_plasma_membrane	0.70079274
50	MP0004742_abnormal_vestibular_system	0.66382801
51	MP0002111_abnormal_tail_morphology	0.63773993
52	MP0002638_abnormal_pupillary_reflex	0.63401066
53	MP0010352_gastrointestinal_tract_polyps	0.58102232
54	MP0003806_abnormal_nucleotide_metabolis	0.57208639
55	MP0004858_abnormal_nervous_system	0.56658934
56	MP0005499_abnormal_olfactory_system	0.56251885
57	MP0005394_taste/olfaction_phenotype	0.56251885
58	MP0008569_lethality_at_weaning	0.56161407
59	MP0003011_delayed_dark_adaptation	0.54371994
60	MP0001243_abnormal_dermal_layer	0.53726116
61	MP0005257_abnormal_intraocular_pressure	0.53521177
62	MP0009780_abnormal_chondrocyte_physiolo	0.51729963
63	MP0000470_abnormal_stomach_morphology	0.51666595
64	MP0000858_altered_metastatic_potential	0.49752894
65	MP0005076_abnormal_cell_differentiation	0.48924834
66	MP0010386_abnormal_urinary_bladder	0.48704458
67	MP0004019_abnormal_vitamin_homeostasis	0.48401138
68	MP0003638_abnormal_response/metabolism_	0.47778826
69	MP0001340_abnormal_eyelid_morphology	0.47218352
70	MP0002095_abnormal_skin_pigmentation	0.43280764
71	MP0002697_abnormal_eye_size	0.42064390
72	MP0002089_abnormal_postnatal_growth/wei	0.41265474
73	MP0001765_abnormal_ion_homeostasis	0.39886502
74	MP0010030_abnormal_orbit_morphology	0.39771843
75	MP0001784_abnormal_fluid_regulation	0.39580449
76	MP0005197_abnormal_uvea_morphology	0.37031764
77	MP0009379_abnormal_foot_pigmentation	0.36810463
78	MP0005187_abnormal_penis_morphology	0.34582092
79	MP0000538_abnormal_urinary_bladder	0.32252226
80	MP0008874_decreased_physiological_sensi	0.32161001
81	MP0001188_hyperpigmentation	0.31360142
82	MP0000003_abnormal_adipose_tissue	0.30713732
83	MP0004197_abnormal_fetal_growth/weight/	0.30194270
84	MP0000462_abnormal_digestive_system	0.29863473
85	MP0002177_abnormal_outer_ear	0.28595420
86	MP0000465_gastrointestinal_hemorrhage	0.28477424
87	MP0009046_muscle_twitch	0.27888315
88	MP0001299_abnormal_eye_distance/	0.27740132
89	MP0000750_abnormal_muscle_regeneration	0.25472596
90	MP0005193_abnormal_anterior_eye	0.25076471
91	MP0002282_abnormal_trachea_morphology	0.23784577
92	MP0001984_abnormal_olfaction	0.23499396
93	MP0001440_abnormal_grooming_behavior	0.22848307
94	MP0000432_abnormal_head_morphology	0.21933333
95	MP0001502_abnormal_circadian_rhythm	0.21319950
96	MP0002133_abnormal_respiratory_system	0.21288694
97	MP0005388_respiratory_system_phenotype	0.21288694
98	MP0006035_abnormal_mitochondrial_morpho	0.20608153
99	MP0005621_abnormal_cell_physiology	0.19838848
100	MP0002086_abnormal_extraembryonic_tissu	0.19545972

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Plantar hyperkeratosis (HP:0007556)	8.35855683
2	Onycholysis (HP:0001806)	8.33644359
3	Palmoplantar hyperkeratosis (HP:0000972)	7.79365183
4	Palmar hyperkeratosis (HP:0010765)	7.37247230
5	Thick nail (HP:0001805)	7.29564377
6	Oral leukoplakia (HP:0002745)	7.07131892
7	Alopecia of scalp (HP:0002293)	6.87500927
8	Fragile nails (HP:0001808)	6.42626876
9	Milia (HP:0001056)	6.41495391
10	Right ventricular cardiomyopathy (HP:0011663)	5.41878457
11	Nail dystrophy (HP:0008404)	5.25248316
12	Hypotrichosis (HP:0001006)	4.78281195
13	Erythroderma (HP:0001019)	4.53623211
14	Congenital ichthyosiform erythroderma (HP:0007431)	4.50837574
15	Pili torti (HP:0003777)	4.42099384
16	Woolly hair (HP:0002224)	4.42060896
17	Atrophic scars (HP:0001075)	4.37001659
18	Sparse eyelashes (HP:0000653)	4.27625990
19	Corneal erosion (HP:0200020)	4.21720116
20	Abnormal blistering of the skin (HP:0008066)	4.19149722
21	Abnormality of the axillary hair (HP:0100134)	4.16175617
22	Abnormality of secondary sexual hair (HP:0009888)	4.16175617
23	Increased IgE level (HP:0003212)	4.07636906
24	Ridged nail (HP:0001807)	4.03926542
25	Erythema (HP:0010783)	3.95473317
26	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.72917787
27	Abnormal hair laboratory examination (HP:0003328)	3.61389883
28	Lip pit (HP:0100267)	3.45310259
29	Palmoplantar keratoderma (HP:0000982)	3.43773121
30	Absent eyelashes (HP:0000561)	3.37808943
31	Parakeratosis (HP:0001036)	3.30930667
32	Sparse scalp hair (HP:0002209)	3.28934634
33	Hypohidrosis (HP:0000966)	3.19275056
34	Ectropion (HP:0000656)	3.18611038
35	Follicular hyperkeratosis (HP:0007502)	3.14328276
36	Abnormality of the salivary glands (HP:0010286)	3.10562299
37	Blepharitis (HP:0000498)	2.99338844
38	Natal tooth (HP:0000695)	2.96431991
39	Abnormality of placental membranes (HP:0011409)	2.94975545
40	Amniotic constriction ring (HP:0009775)	2.94975545
41	Absent hair (HP:0002298)	2.85601350
42	Anonychia (HP:0001798)	2.80600816
43	Hypoplasia of dental enamel (HP:0006297)	2.63640723
44	Selective tooth agenesis (HP:0001592)	2.63554942
45	Pterygium (HP:0001059)	2.55738287
46	Advanced eruption of teeth (HP:0006288)	2.50573744
47	Pustule (HP:0200039)	2.48555214
48	Aplasia cutis congenita (HP:0001057)	2.43779375
49	Dry hair (HP:0011359)	2.40990997
50	Furrowed tongue (HP:0000221)	2.39729084
51	Hypoplastic labia majora (HP:0000059)	2.39595875
52	Autoamputation (HP:0001218)	2.33236470
53	Popliteal pterygium (HP:0009756)	2.32507611
54	Squamous cell carcinoma (HP:0002860)	2.30057236
55	Abnormality of the dental pulp (HP:0006479)	2.28914591
56	Hyperhidrosis (HP:0000975)	2.27789938
57	Carious teeth (HP:0000670)	2.25633715
58	Laryngomalacia (HP:0001601)	2.24003560
59	Oligodontia (HP:0000677)	2.20795697
60	Abnormality of the labia majora (HP:0012881)	2.14612264
61	Split foot (HP:0001839)	2.14611123
62	Multifactorial inheritance (HP:0001426)	2.06351036
63	Amelogenesis imperfecta (HP:0000705)	2.04544507
64	Epidermoid cyst (HP:0200040)	2.03558198
65	Abnormality of the dental root (HP:0006486)	2.03034401
66	Taurodontia (HP:0000679)	2.03034401
67	Abnormality of permanent molar morphology (HP:0011071)	2.03034401
68	Fragile skin (HP:0001030)	2.02859129
69	Dehydration (HP:0001944)	2.02304577
70	Abnormality of nail color (HP:0100643)	11.8098641
71	Abnormality of the fingernails (HP:0001231)	1.98039147
72	Conical tooth (HP:0000698)	1.96336125
73	Dysmetric saccades (HP:0000641)	1.96017254
74	Abnormality of the neuromuscular junction (HP:0003398)	1.95186000
75	Fatigable weakness (HP:0003473)	1.95186000
76	Corneal dystrophy (HP:0001131)	1.94630874
77	Ventricular tachycardia (HP:0004756)	1.88064732
78	Abnormality of molar morphology (HP:0011070)	1.86682709
79	Abnormality of molar (HP:0011077)	1.86682709
80	Brittle hair (HP:0002299)	1.82983960
81	Recurrent corneal erosions (HP:0000495)	1.82934730
82	Skin ulcer (HP:0200042)	1.78206156
83	Pruritus (HP:0000989)	1.77926251
84	Gangrene (HP:0100758)	1.74655858
85	Hydroureter (HP:0000072)	1.73697624
86	Hypodontia (HP:0000668)	1.69722922
87	Ankyloglossia (HP:0010296)	1.65696892
88	Absent hand (HP:0004050)	1.63886655
89	Xerostomia (HP:0000217)	1.57111825
90	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	1.55337594
91	Esophageal atresia (HP:0002032)	1.52089971
92	Septate vagina (HP:0001153)	1.50332152
93	Nasolacrimal duct obstruction (HP:0000579)	1.50252570
94	Acanthosis nigricans (HP:0000956)	1.45997945
95	Urticaria (HP:0001025)	1.45906960
96	Labial hypoplasia (HP:0000066)	1.45349079
97	Breast hypoplasia (HP:0003187)	1.43863390
98	Slow-growing hair (HP:0002217)	1.42399011
99	Abnormality of hair growth rate (HP:0011363)	1.42399011
100	Duplicated collecting system (HP:0000081)	1.42124708

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	7.80398545
2	MST1R	5.71134702
3	SIK1	4.19017111
4	LATS2	3.29162268
5	MET	3.20076265
6	LMTK2	3.02310895
7	MAP3K9	2.78368724
8	RIPK1	2.60192033
9	TGFBR1	2.15747717
10	ARAF	2.11131960
11	MAPKAPK3	2.07489249
12	SMG1	1.84876051
13	EPHB2	1.79690654
14	MAP3K2	1.78119027
15	PIM2	1.75002188
16	FER	1.73419175
17	ERN1	1.65739057
18	MAP3K3	1.62547507
19	SIK3	1.54090590
20	MAP3K6	1.43843028
21	ICK	1.43430524
22	PTK2	1.41707523
23	NTRK1	1.37365320
24	LATS1	1.34043966
25	MAP3K12	1.33038933
26	STK24	1.22767113
27	NME1	1.21984739
28	MAPK15	1.18525026
29	PAK4	1.15648702
30	BMX	1.13987349
31	PBK	1.12139028
32	MST4	1.09124102
33	IRAK3	1.00959746
34	PRKG2	0.98533410
35	SIK2	0.85947168
36	RPS6KB2	0.85386036
37	PHKG2	0.81526607
38	PHKG1	0.81526607
39	PTK6	0.81306961
40	BRAF	0.80932616
41	GRK5	0.80369050
42	CDK12	0.76715835
43	TESK1	0.73301600
44	TTK	0.72009740
45	PRKCI	0.71471655
46	PDGFRA	0.66046199
47	NEK6	0.61944781
48	CDK8	0.61577767
49	GRK6	0.61184409
50	MAP2K6	0.60909635
51	TRPM7	0.59881866
52	FLT3	0.59732998
53	TAOK1	0.58896847
54	IRAK2	0.56713711
55	EEF2K	0.56091210
56	RPS6KA2	0.55449725
57	TRIB3	0.53004873
58	MARK2	0.50690870
59	MTOR	0.48160269
60	MAPKAPK2	0.46715257
61	IKBKB	0.45296858
62	ILK	0.44778822
63	IRAK1	0.42481753
64	ROCK2	0.42006205
65	RPS6KB1	0.40693695
66	STK38	0.40116724
67	MAP3K1	0.38936665
68	NME2	0.38520800
69	PDGFRB	0.37983641
70	WNK1	0.36473137
71	RPS6KA1	0.36362915
72	CDC42BPA	0.35766408
73	RPS6KA4	0.35500633
74	PRKCE	0.35110634
75	RPS6KC1	0.34522507
76	RPS6KL1	0.34522507
77	MAP3K13	0.33948763
78	FGFR3	0.32769440
79	EPHB1	0.32012160
80	FGFR4	0.31523066
81	DMPK	0.31394542
82	STK10	0.31186152
83	SRC	0.30538627
84	RPS6KA6	0.30448935
85	FGR	0.29243579
86	FGFR1	0.26758650
87	JAK3	0.26252692
88	CSF1R	0.26147230
89	ERBB2	0.25928639
90	GSK3A	0.25714845
91	CSNK1A1	0.23683341
92	ERBB4	0.22039295
93	CAMK2G	0.21989033
94	CDK7	0.21777376
95	ADRBK1	0.21263367
96	MAP3K7	0.20531098
97	DDR2	0.18967196
98	MAP3K8	0.18892306
99	PRKCD	0.18776109
100	PRPF4B	0.18725509

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.73400481
2	ECM-receptor interaction_Homo sapiens_hsa04512	3.42032291
3	Linoleic acid metabolism_Homo sapiens_hsa00591	2.98506510
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.81568942
5	Long-term depression_Homo sapiens_hsa04730	2.65484757
6	Ether lipid metabolism_Homo sapiens_hsa00565	2.50982116
7	Nitrogen metabolism_Homo sapiens_hsa00910	1.98657749
8	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.90889941
9	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.90404025
10	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.82190480
11	Small cell lung cancer_Homo sapiens_hsa05222	1.81410683
12	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.77993085
13	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.69365865
14	Notch signaling pathway_Homo sapiens_hsa04330	1.65153744
15	Sphingolipid metabolism_Homo sapiens_hsa00600	1.61555910
16	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.59741738
17	Amoebiasis_Homo sapiens_hsa05146	1.57317410
18	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.53605256
19	VEGF signaling pathway_Homo sapiens_hsa04370	1.52645703
20	GnRH signaling pathway_Homo sapiens_hsa04912	1.49959422
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.38442527
22	Steroid biosynthesis_Homo sapiens_hsa00100	1.34152727
23	p53 signaling pathway_Homo sapiens_hsa04115	1.33266854
24	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.32351388
25	Folate biosynthesis_Homo sapiens_hsa00790	1.28095246
26	Pancreatic secretion_Homo sapiens_hsa04972	1.27498374
27	Renin secretion_Homo sapiens_hsa04924	1.27468975
28	Serotonergic synapse_Homo sapiens_hsa04726	1.26305341
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.23714017
30	Bladder cancer_Homo sapiens_hsa05219	1.22236851
31	Phototransduction_Homo sapiens_hsa04744	1.21838966
32	Adherens junction_Homo sapiens_hsa04520	1.21115227
33	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.20402113
34	Mineral absorption_Homo sapiens_hsa04978	1.09211302
35	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.06921128
36	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	1.05059780
37	Focal adhesion_Homo sapiens_hsa04510	1.04895429
38	Glycerolipid metabolism_Homo sapiens_hsa00561	1.04860180
39	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04810122
40	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.04626023
41	Proteoglycans in cancer_Homo sapiens_hsa05205	1.03853073
42	Axon guidance_Homo sapiens_hsa04360	1.02825376
43	Hippo signaling pathway_Homo sapiens_hsa04390	1.02124584
44	Taste transduction_Homo sapiens_hsa04742	1.00327670
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99979110
46	ErbB signaling pathway_Homo sapiens_hsa04012	0.96842646
47	MicroRNAs in cancer_Homo sapiens_hsa05206	0.94533200
48	Salivary secretion_Homo sapiens_hsa04970	0.91224393
49	Gastric acid secretion_Homo sapiens_hsa04971	0.91111504
50	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.90871817
51	Protein digestion and absorption_Homo sapiens_hsa04974	0.90866591
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.90066117
53	Tight junction_Homo sapiens_hsa04530	0.89730587
54	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.87529634
55	ABC transporters_Homo sapiens_hsa02010	0.87309064
56	Ras signaling pathway_Homo sapiens_hsa04014	0.87211329
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.87068423
58	Olfactory transduction_Homo sapiens_hsa04740	0.86003385
59	Estrogen signaling pathway_Homo sapiens_hsa04915	0.85150986
60	Circadian entrainment_Homo sapiens_hsa04713	0.84172118
61	Long-term potentiation_Homo sapiens_hsa04720	0.82918509
62	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.80652688
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.80510123
64	Basal cell carcinoma_Homo sapiens_hsa05217	0.79677407
65	GABAergic synapse_Homo sapiens_hsa04727	0.76904670
66	Endocytosis_Homo sapiens_hsa04144	0.76612436
67	Pathways in cancer_Homo sapiens_hsa05200	0.76122805
68	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.75634263
69	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75598617
70	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.72791465
71	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70748441
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70525301
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.68543303
74	Melanoma_Homo sapiens_hsa05218	0.68288967
75	Retinol metabolism_Homo sapiens_hsa00830	0.67154576
76	Sulfur relay system_Homo sapiens_hsa04122	0.64943344
77	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.64454328
78	Prion diseases_Homo sapiens_hsa05020	0.63673793
79	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.59884523
80	Melanogenesis_Homo sapiens_hsa04916	0.59387255
81	Glioma_Homo sapiens_hsa05214	0.59209301
82	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.59168141
83	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58486010
84	Rap1 signaling pathway_Homo sapiens_hsa04015	0.56375399
85	Toxoplasmosis_Homo sapiens_hsa05145	0.54889409
86	Calcium signaling pathway_Homo sapiens_hsa04020	0.53556360
87	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.51623717
88	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51170512
89	Insulin signaling pathway_Homo sapiens_hsa04910	0.49532257
90	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.47529558
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.45441462
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.45108713
93	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.44470307
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.44118006
95	Gap junction_Homo sapiens_hsa04540	0.43032407
96	Nicotine addiction_Homo sapiens_hsa05033	0.42232068
97	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.40752926
98	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.39774159
99	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.35702832
100	Morphine addiction_Homo sapiens_hsa05032	0.34965748

KRT16P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »