KRT16P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of glomerulus development (GO:0090193)9.10891764
2regulation of transforming growth factor beta1 production (GO:0032908)8.77762744
3positive regulation of interleukin-8 secretion (GO:2000484)8.67659763
4hemidesmosome assembly (GO:0031581)8.55259073
5keratinocyte proliferation (GO:0043616)8.45072208
6molting cycle (GO:0042303)8.28504721
7hair cycle (GO:0042633)8.28504721
8keratinocyte differentiation (GO:0030216)7.81382452
9positive regulation of humoral immune response (GO:0002922)7.18960901
10regulation of cell proliferation involved in kidney development (GO:1901722)7.06973292
11bundle of His cell to Purkinje myocyte communication (GO:0086069)7.01131953
12epidermal cell differentiation (GO:0009913)6.93429048
13multicellular organismal water homeostasis (GO:0050891)6.80875543
14regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)6.65056422
15positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)6.65056422
16regulation of interleukin-8 secretion (GO:2000482)6.39910603
17defense response to Gram-negative bacterium (GO:0050829)6.26592682
18positive regulation of p38MAPK cascade (GO:1900745)6.12880849
19intermediate filament organization (GO:0045109)6.07962480
20water homeostasis (GO:0030104)5.97264104
21epidermis development (GO:0008544)5.90262092
22regulation of glomerulus development (GO:0090192)5.88868849
23regulation of cellular amide metabolic process (GO:0034248)5.88495180
24positive regulation of T-helper 1 type immune response (GO:0002827)5.68017942
25peptide cross-linking (GO:0018149)5.24724542
26defense response to fungus (GO:0050832)5.22616240
27intermediate filament cytoskeleton organization (GO:0045104)5.13643699
28phosphatidylinositol acyl-chain remodeling (GO:0036149)5.09605067
29phosphatidylserine acyl-chain remodeling (GO:0036150)5.04080271
30surfactant homeostasis (GO:0043129)4.99402629
31antimicrobial humoral response (GO:0019730)4.98037086
32ectoderm development (GO:0007398)4.97423985
33intermediate filament-based process (GO:0045103)4.96967469
34positive regulation of transforming growth factor beta production (GO:0071636)4.84650659
35positive regulation of epidermis development (GO:0045684)4.81209571
36activation of MAPKKK activity (GO:0000185)4.66907446
37negative regulation of keratinocyte proliferation (GO:0010839)4.59631910
38regulation of MHC class I biosynthetic process (GO:0045343)4.56813547
39regulation of p38MAPK cascade (GO:1900744)4.54232892
40chemical homeostasis within a tissue (GO:0048875)4.54189449
41negative regulation of interleukin-17 production (GO:0032700)4.49006368
42natural killer cell activation involved in immune response (GO:0002323)4.40489215
43phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.36077309
44nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)4.32439993
45keratinocyte development (GO:0003334)4.31361837
46fatty acid elongation (GO:0030497)4.22193445
47positive regulation of epidermal cell differentiation (GO:0045606)4.13604949
48skin morphogenesis (GO:0043589)4.10291830
49regulation of T-helper 1 type immune response (GO:0002825)4.01330434
50regulation of hair cycle (GO:0042634)3.96857627
51antibacterial humoral response (GO:0019731)3.92479190
52phosphatidylcholine acyl-chain remodeling (GO:0036151)3.89371069
53positive regulation of meiotic cell cycle (GO:0051446)3.88994446
54positive regulation of response to biotic stimulus (GO:0002833)3.88742288
55dendritic cell migration (GO:0036336)3.85795209
56long-chain fatty acid biosynthetic process (GO:0042759)3.80394175
57positive regulation of keratinocyte differentiation (GO:0045618)3.76791801
58regulation of transforming growth factor beta production (GO:0071634)3.56832367
59response to fungus (GO:0009620)3.55182418
60negative regulation of interferon-gamma production (GO:0032689)3.30970502
61regulation of ruffle assembly (GO:1900027)3.29993427
62phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.29537974
63cell-substrate junction assembly (GO:0007044)3.25428552
64cellular response to arsenic-containing substance (GO:0071243)3.25095899
65negative regulation of meiotic cell cycle (GO:0051447)3.24321101
66phosphatidylserine metabolic process (GO:0006658)3.23706201
67lipoxygenase pathway (GO:0019372)3.21296613
68positive regulation of cholesterol efflux (GO:0010875)3.15814648
69regulation of epidermis development (GO:0045682)3.13394013
70ventricular cardiac muscle cell action potential (GO:0086005)3.10985517
71regulation of keratinocyte proliferation (GO:0010837)3.10651323
72positive regulation of hair cycle (GO:0042635)3.09639106
73positive regulation of hair follicle development (GO:0051798)3.09639106
74negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07753432
75positive regulation of cholesterol transport (GO:0032376)3.07503844
76positive regulation of sterol transport (GO:0032373)3.07503844
77regulation of collagen biosynthetic process (GO:0032965)3.04382023
78early endosome to late endosome transport (GO:0045022)3.03050324
79keratinization (GO:0031424)22.3531381
80positive regulation of collagen biosynthetic process (GO:0032967)2.99143899
81bile acid and bile salt transport (GO:0015721)2.98838367
82regulation of neuron projection regeneration (GO:0070570)2.96341953
83regulation of axon regeneration (GO:0048679)2.96341953
84branching involved in labyrinthine layer morphogenesis (GO:0060670)2.95053221
85positive regulation of interleukin-6 production (GO:0032755)2.86445089
86positive regulation of collagen metabolic process (GO:0010714)2.82140059
87regulation of hair follicle development (GO:0051797)2.81435170
88hair cell differentiation (GO:0035315)2.75424400
89detection of bacterium (GO:0016045)2.75221199
90response to UV-B (GO:0010224)2.73866444
91gap junction assembly (GO:0016264)2.72613380
92regulation of protein localization to cell surface (GO:2000008)2.72226298
93epithelium development (GO:0060429)2.72171727
94linoleic acid metabolic process (GO:0043651)2.70897689
95cellular protein complex localization (GO:0034629)2.68816244
96phospholipid efflux (GO:0033700)2.64180135
97establishment of skin barrier (GO:0061436)12.6031694
98positive regulation of cellular amide metabolic process (GO:0034250)11.3713536
99regulation of water loss via skin (GO:0033561)11.0846196
100desmosome organization (GO:0002934)10.1051509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.82764975
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.59869606
3SMAD4_19686287_ChIP-ChIP_HaCaT_Human4.23764999
4P63_26484246_Chip-Seq_KERATINOCYTES_Human4.14636283
5SMAD2_18955504_ChIP-ChIP_HaCaT_Human3.56892435
6SMAD3_18955504_ChIP-ChIP_HaCaT_Human3.56892435
7SOX9_24532713_ChIP-Seq_HFSC_Mouse2.24129562
8TP63_23658742_ChIP-Seq_EP156T_Human2.23936279
9TP63_17297297_ChIP-ChIP_HaCaT_Human13.0160848
10FOXO3_23340844_ChIP-Seq_DLD1_Human1.97691070
11HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95346925
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74716478
13STAT6_21828071_ChIP-Seq_BEAS2B_Human1.71859530
14JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.64950549
15ATF3_27146783_Chip-Seq_COLON_Human1.63170920
16TP63_22573176_ChIP-Seq_HFKS_Human1.62967024
17ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.60351500
18RXR_22108803_ChIP-Seq_LS180_Human1.56227506
19JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53686838
20GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.52026870
21FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.44469481
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.43727219
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39320509
24KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36761836
25TP53_18474530_ChIP-ChIP_U2OS_Human1.31934649
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26539745
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.25972342
28UBF1/2_26484160_Chip-Seq_HMECs_Human1.23637977
29EGR1_19032775_ChIP-ChIP_M12_Human1.22069715
30KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20888117
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20181742
32SOX2_20726797_ChIP-Seq_SW620_Human1.20040283
33CTCF_27219007_Chip-Seq_Bcells_Human1.19071139
34GATA6_21074721_ChIP-Seq_CACO-2_Human1.18752168
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.18376245
36TP53_16413492_ChIP-PET_HCT116_Human1.16366537
37ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15947459
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.13579448
39CJUN_26792858_Chip-Seq_BT549_Human1.12732554
40TCF4_18268006_ChIP-ChIP_LS174T_Human1.12091560
41AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11482030
42SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06392421
43HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04945634
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03198645
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01777672
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01269287
47UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98055222
48KLF5_25053715_ChIP-Seq_YYC3_Human0.97256024
49PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96354076
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.95651192
51FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95003682
52BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.92050281
53SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90916204
54GATA4_25053715_ChIP-Seq_YYC3_Human0.88413250
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88301401
56GATA3_24758297_ChIP-Seq_MCF-7_Human0.84806250
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84040334
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83974273
59CTCF_20526341_ChIP-Seq_ESCs_Human0.83816029
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.81925485
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81825200
62RACK7_27058665_Chip-Seq_MCF-7_Human0.80689160
63TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79599096
64CEBPB_22108803_ChIP-Seq_LS180_Human0.78475675
65PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77172352
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76834345
67P53_21459846_ChIP-Seq_SAOS-2_Human0.76571867
68STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76359049
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.75748720
70RUNX1_27514584_Chip-Seq_MCF-7_Human0.75626950
71NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75512717
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75512717
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75506589
74MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.65451499
75E2F1_20622854_ChIP-Seq_HELA_Human0.64685332
76CDX2_19796622_ChIP-Seq_MESCs_Mouse0.64124411
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.62317650
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.62317650
79FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.61851997
80RBPJ_21746931_ChIP-Seq_IB4_Human0.60381398
81NCOR_22424771_ChIP-Seq_293T_Human0.58166135
82P300_27058665_Chip-Seq_ZR-75-30cells_Human0.57778863
83GATA6_25053715_ChIP-Seq_YYC3_Human0.57754947
84HNFA_21074721_ChIP-Seq_CACO-2_Human0.57631304
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.57250913
86THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.56437504
87TCF3_18692474_ChIP-Seq_MESCs_Mouse0.56429610
88TBL1_22424771_ChIP-Seq_293T_Human0.56110958
89AR_21572438_ChIP-Seq_LNCaP_Human0.55327626
90SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.54713918
91CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.54508143
92GATA2_21666600_ChIP-Seq_HMVEC_Human0.54327171
93ERG_20517297_ChIP-Seq_VCAP_Human0.53656318
94FOXA1_21572438_ChIP-Seq_LNCaP_Human0.53280539
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.53226598
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.52873482
97SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.52404376
98AR_25329375_ChIP-Seq_VCAP_Human0.50539735
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.49999261
100GATA3_26560356_Chip-Seq_TH2_Human0.49591388

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology8.24757324
2MP0002796_impaired_skin_barrier7.79658261
3MP0010234_abnormal_vibrissa_follicle7.60412731
4MP0003941_abnormal_skin_development5.03435865
5MP0005275_abnormal_skin_tensile4.75857248
6MP0005501_abnormal_skin_physiology4.33838624
7MP0010678_abnormal_skin_adnexa3.70116528
8MP0004381_abnormal_hair_follicle3.40040230
9MP0000467_abnormal_esophagus_morphology3.09764277
10MP0001216_abnormal_epidermal_layer3.08657225
11MP0003453_abnormal_keratinocyte_physiol3.00380872
12MP0002098_abnormal_vibrissa_morphology2.94766326
13MP0000762_abnormal_tongue_morphology2.69371090
14MP0010771_integument_phenotype2.68399697
15MP0003950_abnormal_plasma_membrane2.64782983
16MP0000383_abnormal_hair_follicle2.61949238
17MP0002060_abnormal_skin_morphology2.61608053
18MP0003191_abnormal_cellular_cholesterol2.45859669
19MP0000377_abnormal_hair_follicle2.23540582
20MP0003566_abnormal_cell_adhesion2.09561500
21MP0004947_skin_inflammation2.07349272
22MP0000566_synostosis1.84897393
23MP0004782_abnormal_surfactant_physiolog1.81407374
24MP0005409_darkened_coat_color1.62992761
25MP0000427_abnormal_hair_cycle1.58527684
26MP0002234_abnormal_pharynx_morphology1.54444159
27MP0004885_abnormal_endolymph1.53889117
28MP0009931_abnormal_skin_appearance1.43138108
29MP0000367_abnormal_coat/_hair1.37434575
30MP0004264_abnormal_extraembryonic_tissu1.31502108
31MP0004272_abnormal_basement_membrane1.22212635
32MP0003705_abnormal_hypodermis_morpholog1.21521876
33MP0009053_abnormal_anal_canal1.21398324
34MP0005023_abnormal_wound_healing1.10954349
35MP0001191_abnormal_skin_condition1.09147047
36MP0003011_delayed_dark_adaptation1.08499276
37MP0008004_abnormal_stomach_pH0.93668281
38MP0000647_abnormal_sebaceous_gland0.93246112
39MP0003656_abnormal_erythrocyte_physiolo0.76253739
40MP0003315_abnormal_perineum_morphology0.75791147
41MP0001851_eye_inflammation0.74751779
42MP0003755_abnormal_palate_morphology0.69558462
43MP0001784_abnormal_fluid_regulation0.63190225
44MP0003221_abnormal_cardiomyocyte_apopto0.58741258
45MP0004185_abnormal_adipocyte_glucose0.58434533
46MP0001243_abnormal_dermal_layer0.54496393
47MP0009840_abnormal_foam_cell0.53769465
48MP0002136_abnormal_kidney_physiology0.47745226
49MP0001340_abnormal_eyelid_morphology0.46253126
50MP0003828_pulmonary_edema0.43385880
51MP0000627_abnormal_mammary_gland0.43030916
52MP0001177_atelectasis0.42058696
53MP0001765_abnormal_ion_homeostasis0.41922429
54MP0008260_abnormal_autophagy0.40068426
55MP0002095_abnormal_skin_pigmentation0.38936569
56MP0003329_amyloid_beta_deposits0.37992262
57MP0000003_abnormal_adipose_tissue0.37549792
58MP0010352_gastrointestinal_tract_polyps0.35898318
59MP0002697_abnormal_eye_size0.35812856
60MP0000470_abnormal_stomach_morphology0.35583802
61MP0003638_abnormal_response/metabolism_0.35179616
62MP0001299_abnormal_eye_distance/0.34526023
63MP0000678_abnormal_parathyroid_gland0.34520554
64MP0005375_adipose_tissue_phenotype0.34342864
65MP0009672_abnormal_birth_weight0.34342818
66MP0004270_analgesia0.33617604
67MP0002177_abnormal_outer_ear0.33159744
68MP0001440_abnormal_grooming_behavior0.31446573
69MP0008058_abnormal_DNA_repair0.30490764
70MP0001849_ear_inflammation0.30371917
71MP0005075_abnormal_melanosome_morpholog0.27563311
72MP0001756_abnormal_urination0.26211890
73MP0004197_abnormal_fetal_growth/weight/0.23432663
74MP0002111_abnormal_tail_morphology0.23335657
75MP0009333_abnormal_splenocyte_physiolog0.23053371
76MP0001502_abnormal_circadian_rhythm0.22588736
77MP0002069_abnormal_eating/drinking_beha0.22164809
78MP0009765_abnormal_xenobiotic_induced0.21240192
79MP0001188_hyperpigmentation0.20869106
80MP0003786_premature_aging0.20328208
81MP0001501_abnormal_sleep_pattern0.19936509
82MP0004043_abnormal_pH_regulation0.19027161
83MP0003878_abnormal_ear_physiology0.18315906
84MP0005377_hearing/vestibular/ear_phenot0.18315906
85MP0005388_respiratory_system_phenotype0.18292057
86MP0002133_abnormal_respiratory_system0.18292057
87MP0005193_abnormal_anterior_eye0.16960693
88MP0000465_gastrointestinal_hemorrhage0.15838677
89MP0005451_abnormal_body_composition0.15371096
90MP0000569_abnormal_digit_pigmentation0.15251364
91MP0003806_abnormal_nucleotide_metabolis0.14497809
92MP0000537_abnormal_urethra_morphology0.13647076
93MP0004019_abnormal_vitamin_homeostasis0.13548157
94MP0004510_myositis0.13461681
95MP0008007_abnormal_cellular_replicative0.12733226
96MP0005197_abnormal_uvea_morphology0.12142173
97MP0000230_abnormal_systemic_arterial0.12098711
98MP0008569_lethality_at_weaning0.10995514
99MP0005248_abnormal_Harderian_gland0.10924484
100MP0005636_abnormal_mineral_homeostasis0.10758891

Predicted human phenotypes

RankGene SetZ-score
1Palmoplantar hyperkeratosis (HP:0000972)8.79929001
2Palmar hyperkeratosis (HP:0010765)8.36166007
3Plantar hyperkeratosis (HP:0007556)8.17614765
4Thick nail (HP:0001805)7.43319113
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.33762217
6Increased IgE level (HP:0003212)7.24998794
7Parakeratosis (HP:0001036)7.17090811
8Oral leukoplakia (HP:0002745)6.93166109
9Congenital ichthyosiform erythroderma (HP:0007431)6.89577721
10Erythroderma (HP:0001019)5.77030118
11Fragile nails (HP:0001808)5.69840971
12Onycholysis (HP:0001806)5.54105486
13Erythema (HP:0010783)5.21670380
14Milia (HP:0001056)5.03268635
15Follicular hyperkeratosis (HP:0007502)4.74984600
16Alopecia of scalp (HP:0002293)4.62321834
17Nail dystrophy (HP:0008404)4.54412826
18Right ventricular cardiomyopathy (HP:0011663)4.53753704
19Palmoplantar keratoderma (HP:0000982)4.47843843
20Corneal erosion (HP:0200020)4.10616790
21Abnormal blistering of the skin (HP:0008066)4.06706710
22Ectropion (HP:0000656)3.99488476
23Hypotrichosis (HP:0001006)3.92556077
24Natal tooth (HP:0000695)3.75494084
25Hypohidrosis (HP:0000966)3.54288607
26Woolly hair (HP:0002224)3.52569045
27Hyperhidrosis (HP:0000975)3.52237561
28Lip pit (HP:0100267)3.51570880
29Pustule (HP:0200039)3.40782034
30Ridged nail (HP:0001807)3.28749700
31Sparse scalp hair (HP:0002209)3.24213623
32Laryngomalacia (HP:0001601)3.22438015
33Corneal dystrophy (HP:0001131)3.12310423
34Abnormality of secondary sexual hair (HP:0009888)2.93958938
35Abnormality of the axillary hair (HP:0100134)2.93958938
36Anonychia (HP:0001798)2.81957293
37Gangrene (HP:0100758)2.80220049
38Atrophic scars (HP:0001075)2.73289021
39Furrowed tongue (HP:0000221)2.69513178
40Pruritus (HP:0000989)2.65504165
41Amniotic constriction ring (HP:0009775)2.59237913
42Abnormality of placental membranes (HP:0011409)2.59237913
43Popliteal pterygium (HP:0009756)2.56692204
44Advanced eruption of teeth (HP:0006288)2.55870233
45Sparse eyelashes (HP:0000653)2.50962611
46Dehydration (HP:0001944)2.46935513
47Pili torti (HP:0003777)2.46573758
48Ankyloglossia (HP:0010296)2.38691875
49Abnormality of the salivary glands (HP:0010286)2.34183832
50Carious teeth (HP:0000670)2.28576496
51Abnormality of the neuromuscular junction (HP:0003398)2.19441768
52Fatigable weakness (HP:0003473)2.19441768
53Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.18926504
54Epidermoid cyst (HP:0200040)2.16957906
55Dry hair (HP:0011359)2.12141156
56Absent eyelashes (HP:0000561)2.04855535
57Hypoplastic labia majora (HP:0000059)2.03529763
58Abnormal hair laboratory examination (HP:0003328)2.03035343
59Brittle hair (HP:0002299)2.01116073
60Abnormality of nail color (HP:0100643)14.7436135
61Skin ulcer (HP:0200042)1.95235123
62Abnormality of the fingernails (HP:0001231)1.87082791
63Curly hair (HP:0002212)1.86521123
64Dry skin (HP:0000958)1.85362402
65Abnormality of the labia majora (HP:0012881)1.83569860
66Pterygium (HP:0001059)1.83101940
67Villous atrophy (HP:0011473)1.82632299
68Abnormality of small intestinal villus morphology (HP:0011472)1.82632299
69Absent hair (HP:0002298)1.81850635
70Blepharitis (HP:0000498)1.80756388
71Papilloma (HP:0012740)1.80367426
72Verrucae (HP:0200043)1.80367426
73Lack of skin elasticity (HP:0100679)1.77552695
74Acanthosis nigricans (HP:0000956)1.71416950
75Distal lower limb muscle weakness (HP:0009053)1.70867934
76Hypergammaglobulinemia (HP:0010702)1.68469575
77Abnormality of oral frenula (HP:0000190)1.67341426
78Multifactorial inheritance (HP:0001426)1.65242164
79Hypoplasia of dental enamel (HP:0006297)1.63223243
80Fragile skin (HP:0001030)1.60620636
81Neurofibrillary tangles (HP:0002185)1.60165840
82Urticaria (HP:0001025)1.59027721
83Hypoplasia of the uterus (HP:0000013)1.58679056
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.56862389
85Conjunctival hamartoma (HP:0100780)1.51825160
86Cerebral inclusion bodies (HP:0100314)1.51610215
87Vascular calcification (HP:0004934)1.46317066
88Oligodontia (HP:0000677)1.44863380
89Cheilitis (HP:0100825)1.43286701
90Sepsis (HP:0100806)1.42959653
91Ventricular fibrillation (HP:0001663)1.39503650
92Ventricular tachycardia (HP:0004756)1.30536856
93Melanocytic nevus (HP:0000995)1.29621568
94Hypodontia (HP:0000668)1.28031923
95Autoamputation (HP:0001218)1.26184659
96Cardiovascular calcification (HP:0011915)1.25735789
97Aplasia/hypoplasia of the uterus (HP:0008684)1.24412209
98Aplasia cutis congenita (HP:0001057)1.23451355
99Selective tooth agenesis (HP:0001592)1.21867695
100Abnormality of the gastric mucosa (HP:0004295)1.21830117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK13.39120184
2STK243.17638986
3MAP3K93.08277674
4LATS22.29186768
5LATS12.20764892
6EPHA211.5302085
7FRK1.99534989
8MST1R1.86002998
9ABL21.84280633
10PIM21.76269550
11STK38L1.64841773
12MET1.62478344
13DYRK31.56955081
14SIK21.41420634
15ADRBK11.40745234
16IRAK41.37663471
17MAPK151.37368208
18EPHB21.33609030
19MAP3K121.32749048
20TSSK61.31742503
21MOS1.27677406
22TGFBR21.27244599
23PDGFRB1.22093521
24SGK4941.18682760
25SGK2231.18682760
26FER1.18544188
27SGK21.13987983
28IRAK21.13054650
29MAP3K61.12347658
30GRK71.08833836
31SGK31.06398973
32TAOK11.06368656
33IKBKE1.01721472
34STK31.00190741
35PTK20.97170165
36WNK10.96467265
37PDK20.95193173
38FLT30.93528893
39GRK50.93343445
40ADRBK20.93181123
41RIPK10.92580921
42IRAK10.91447196
43TGFBR10.90912131
44LMTK20.89142681
45MAP3K30.85093064
46STK100.82069410
47NTRK10.76167782
48MAP2K10.75131711
49IKBKB0.74104531
50PDGFRA0.71773337
51TRPM70.70301059
52ZAK0.69668450
53ERBB30.67078486
54MAP3K50.64636185
55AKT30.63499459
56BMX0.58239999
57FGR0.58215015
58MST40.56100116
59TBK10.56099719
60SIK10.54031130
61PKN10.53527013
62NEK60.52324148
63STK380.51551024
64GRK60.45918902
65PTK2B0.43963100
66CDK60.43450537
67MAPKAPK30.43038655
68MAP3K20.39907813
69IRAK30.39829543
70MTOR0.39078385
71TAOK20.37453761
72PAK20.36350748
73MAP3K10.36247124
74MAP2K60.34322408
75CHUK0.34194107
76ABL10.32377779
77PTK60.30670450
78ACVR1B0.28223079
79MUSK0.27941436
80PRPF4B0.27134832
81GSK3A0.24994240
82CDK120.24826193
83RPS6KA10.24000803
84GRK10.23460324
85MAP3K140.23116736
86PRKCI0.23101592
87MKNK20.22453302
88MAPK40.22015073
89PRKCE0.21258705
90MAP3K110.19990783
91EPHB10.19184298
92RPS6KA60.18878125
93BCR0.17477516
94PAK40.16710307
95TAF10.16613277
96ARAF0.16563926
97FGFR10.16321527
98DAPK30.16287118
99SGK10.15355497
100EIF2AK20.14968575

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.72953167
2Linoleic acid metabolism_Homo sapiens_hsa005915.43193512
3Ether lipid metabolism_Homo sapiens_hsa005653.60896074
4NOD-like receptor signaling pathway_Homo sapiens_hsa046213.11078999
5Sphingolipid metabolism_Homo sapiens_hsa006002.49908817
6Arachidonic acid metabolism_Homo sapiens_hsa005902.47757482
7p53 signaling pathway_Homo sapiens_hsa041152.41462555
8Ovarian steroidogenesis_Homo sapiens_hsa049132.38576447
9Long-term depression_Homo sapiens_hsa047302.11656472
10RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.84903180
11Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.72872060
12VEGF signaling pathway_Homo sapiens_hsa043701.69863603
13GnRH signaling pathway_Homo sapiens_hsa049121.66342702
14ECM-receptor interaction_Homo sapiens_hsa045121.57219344
15Glycerophospholipid metabolism_Homo sapiens_hsa005641.54636648
16Circadian rhythm_Homo sapiens_hsa047101.48698923
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.45031957
18Dorso-ventral axis formation_Homo sapiens_hsa043201.37966187
19Serotonergic synapse_Homo sapiens_hsa047261.33320703
20Tight junction_Homo sapiens_hsa045301.32554046
21Fatty acid elongation_Homo sapiens_hsa000621.32185666
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.29905849
23Phototransduction_Homo sapiens_hsa047441.23193746
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19717664
25Endocytosis_Homo sapiens_hsa041441.10158923
26Vascular smooth muscle contraction_Homo sapiens_hsa042701.09401395
27Amoebiasis_Homo sapiens_hsa051461.04189893
28ErbB signaling pathway_Homo sapiens_hsa040121.03919476
29Glutamatergic synapse_Homo sapiens_hsa047241.00619397
30Choline metabolism in cancer_Homo sapiens_hsa052310.96896591
31Toxoplasmosis_Homo sapiens_hsa051450.95965825
32MAPK signaling pathway_Homo sapiens_hsa040100.94856150
33Inositol phosphate metabolism_Homo sapiens_hsa005620.92731831
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86318480
35Prion diseases_Homo sapiens_hsa050200.81024086
36Glycerolipid metabolism_Homo sapiens_hsa005610.79495775
37Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78407909
38Ras signaling pathway_Homo sapiens_hsa040140.77683681
39ABC transporters_Homo sapiens_hsa020100.77559730
40Hippo signaling pathway_Homo sapiens_hsa043900.75143140
41Platelet activation_Homo sapiens_hsa046110.74566540
42Estrogen signaling pathway_Homo sapiens_hsa049150.73750261
43Adherens junction_Homo sapiens_hsa045200.72428379
44Bladder cancer_Homo sapiens_hsa052190.69296933
45Fat digestion and absorption_Homo sapiens_hsa049750.68658300
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.67042912
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67033448
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66474981
49Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64997639
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64972550
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63257325
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63239249
53Steroid biosynthesis_Homo sapiens_hsa001000.59548617
54Hepatitis C_Homo sapiens_hsa051600.59096248
55Retinol metabolism_Homo sapiens_hsa008300.58731423
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.58222351
57Collecting duct acid secretion_Homo sapiens_hsa049660.57938949
58Pancreatic secretion_Homo sapiens_hsa049720.57206219
59Small cell lung cancer_Homo sapiens_hsa052220.56434432
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53817108
61Renin-angiotensin system_Homo sapiens_hsa046140.53242818
62Shigellosis_Homo sapiens_hsa051310.52674006
63FoxO signaling pathway_Homo sapiens_hsa040680.52583242
64MicroRNAs in cancer_Homo sapiens_hsa052060.51004411
65Mineral absorption_Homo sapiens_hsa049780.49512981
66Axon guidance_Homo sapiens_hsa043600.48959371
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.47822052
68Synaptic vesicle cycle_Homo sapiens_hsa047210.46354802
69TNF signaling pathway_Homo sapiens_hsa046680.45710772
70Focal adhesion_Homo sapiens_hsa045100.44933567
71Oxytocin signaling pathway_Homo sapiens_hsa049210.44662787
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43257873
73Salmonella infection_Homo sapiens_hsa051320.43195905
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42541721
75Basal transcription factors_Homo sapiens_hsa030220.42525593
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.41658523
77Circadian entrainment_Homo sapiens_hsa047130.40501828
78Calcium signaling pathway_Homo sapiens_hsa040200.40444513
79Influenza A_Homo sapiens_hsa051640.39930216
80Proteoglycans in cancer_Homo sapiens_hsa052050.36781786
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36404563
82Hedgehog signaling pathway_Homo sapiens_hsa043400.36178290
83Basal cell carcinoma_Homo sapiens_hsa052170.35726745
84Renal cell carcinoma_Homo sapiens_hsa052110.33771201
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.32960795
86Apoptosis_Homo sapiens_hsa042100.32793092
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31672788
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.31198566
89Melanogenesis_Homo sapiens_hsa049160.29981083
90Pathways in cancer_Homo sapiens_hsa052000.28061992
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.28050975
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28005866
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24899731
94Vibrio cholerae infection_Homo sapiens_hsa051100.24702064
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23792481
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23178961
97TGF-beta signaling pathway_Homo sapiens_hsa043500.23024586
98Rap1 signaling pathway_Homo sapiens_hsa040150.22685832
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21901497
100Dopaminergic synapse_Homo sapiens_hsa047280.21864040

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