ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of skin barrier (GO:0061436)	9.38255489
2	molting cycle (GO:0042303)	8.83029744
3	hair cycle (GO:0042633)	8.83029744
4	regulation of water loss via skin (GO:0033561)	8.64938972
5	keratinocyte proliferation (GO:0043616)	7.92366795
6	keratinocyte differentiation (GO:0030216)	6.73495929
7	epidermis development (GO:0008544)	6.17113728
8	intermediate filament cytoskeleton organization (GO:0045104)	5.90176713
9	cell-substrate junction assembly (GO:0007044)	5.83059951
10	negative regulation of keratinocyte proliferation (GO:0010839)	5.76662104
11	keratinocyte development (GO:0003334)	5.74362147
12	intermediate filament-based process (GO:0045103)	5.73570165
13	peptide cross-linking (GO:0018149)	5.68319937
14	epidermal cell differentiation (GO:0009913)	5.53351342
15	gap junction assembly (GO:0016264)	5.44453917
16	multicellular organismal water homeostasis (GO:0050891)	5.37131774
17	intermediate filament organization (GO:0045109)	4.96005196
18	skin morphogenesis (GO:0043589)	4.56308969
19	positive regulation of epidermis development (GO:0045684)	4.55454034
20	plasma membrane repair (GO:0001778)	4.39786836
21	water homeostasis (GO:0030104)	4.30611928
22	cell proliferation involved in metanephros development (GO:0072203)	4.11923727
23	positive regulation of epidermal cell differentiation (GO:0045606)	4.08376536
24	membrane tubulation (GO:0097320)	4.02847831
25	regulation of keratinocyte proliferation (GO:0010837)	3.97846808
26	establishment of tissue polarity (GO:0007164)	3.97637568
27	establishment of planar polarity (GO:0001736)	3.97637568
28	ventricular cardiac muscle cell action potential (GO:0086005)	3.94253751
29	embryonic skeletal joint morphogenesis (GO:0060272)	3.93214594
30	surfactant homeostasis (GO:0043129)	3.82973575
31	cell differentiation involved in metanephros development (GO:0072202)	3.82864430
32	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.73370184
33	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.73370184
34	cardiac right ventricle morphogenesis (GO:0003215)	3.72020743
35	planar cell polarity pathway involved in neural tube closure (GO:0090179)	3.68097220
36	positive regulation of gastrulation (GO:2000543)	3.68043637
37	regulation of gene silencing by RNA (GO:0060966)	3.63109080
38	regulation of posttranscriptional gene silencing (GO:0060147)	3.63109080
39	regulation of gene silencing by miRNA (GO:0060964)	3.63109080
40	protein localization to endosome (GO:0036010)	3.56439604
41	regulation of ruffle assembly (GO:1900027)	3.52504246
42	hypotonic response (GO:0006971)	3.47612952
43	pattern specification involved in kidney development (GO:0061004)	3.47132844
44	regulation of transforming growth factor beta1 production (GO:0032908)	3.42316763
45	regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)	3.40824296
46	establishment of apical/basal cell polarity (GO:0035089)	3.38636331
47	chemosensory behavior (GO:0007635)	3.36768983
48	regulation of hair follicle development (GO:0051797)	3.35748936
49	asymmetric protein localization (GO:0008105)	3.34677049
50	epithelium development (GO:0060429)	3.33272670
51	dichotomous subdivision of an epithelial terminal unit (GO:0060600)	3.32326128
52	endodermal cell differentiation (GO:0035987)	3.31653305
53	regulation of heart rate by cardiac conduction (GO:0086091)	3.28446816
54	regulation of epidermis development (GO:0045682)	3.27954591
55	positive regulation of keratinocyte differentiation (GO:0045618)	3.27711645
56	chemical homeostasis within a tissue (GO:0048875)	3.22822758
57	limb bud formation (GO:0060174)	3.21366930
58	lateral sprouting from an epithelium (GO:0060601)	3.15784346
59	apical protein localization (GO:0045176)	3.10779477
60	pyrimidine dimer repair (GO:0006290)	3.02349689
61	ectoderm development (GO:0007398)	2.99855861
62	urogenital system development (GO:0001655)	2.99786614
63	hair cell differentiation (GO:0035315)	2.99044071
64	cell differentiation involved in embryonic placenta development (GO:0060706)	2.97993803
65	notochord development (GO:0030903)	2.96749026
66	cell communication involved in cardiac conduction (GO:0086065)	2.96675051
67	metanephric mesenchyme development (GO:0072075)	2.95290121
68	extracellular matrix disassembly (GO:0022617)	2.93761833
69	negative regulation of fatty acid transport (GO:2000192)	2.92941402
70	positive regulation of hair follicle development (GO:0051798)	2.90147283
71	positive regulation of hair cycle (GO:0042635)	2.90147283
72	cell proliferation involved in kidney development (GO:0072111)	2.89780196
73	skin development (GO:0043588)	2.89759245
74	regulation of transforming growth factor beta2 production (GO:0032909)	2.89669325
75	natural killer cell mediated immunity (GO:0002228)	2.87814241
76	natural killer cell mediated cytotoxicity (GO:0042267)	2.87814241
77	positive regulation of glomerulus development (GO:0090193)	2.87633998
78	collagen metabolic process (GO:0032963)	2.87326345
79	regulation of cell proliferation involved in kidney development (GO:1901722)	2.84685595
80	regulation of keratinocyte differentiation (GO:0045616)	2.83422971
81	activation of Rac GTPase activity (GO:0032863)	2.81685997
82	glial cell migration (GO:0008347)	2.81586389
83	regulation of hair cycle (GO:0042634)	2.81249136
84	positive regulation of odontogenesis (GO:0042482)	2.80594229
85	cell junction assembly (GO:0034329)	2.78407250
86	collagen catabolic process (GO:0030574)	2.78190282
87	establishment or maintenance of monopolar cell polarity (GO:0061339)	2.75286716
88	establishment of monopolar cell polarity (GO:0061162)	2.75286716
89	cell junction organization (GO:0034330)	2.72923298
90	metanephric nephron epithelium development (GO:0072243)	2.66476503
91	cardiac conduction (GO:0061337)	2.66125464
92	activation of JUN kinase activity (GO:0007257)	2.64992007
93	kidney mesenchyme development (GO:0072074)	2.64357240
94	regulation of axon regeneration (GO:0048679)	2.64312326
95	regulation of neuron projection regeneration (GO:0070570)	2.64312326
96	polarized epithelial cell differentiation (GO:0030859)	2.62235316
97	hemidesmosome assembly (GO:0031581)	15.5561829
98	desmosome organization (GO:0002934)	12.5660960
99	bundle of His cell to Purkinje myocyte communication (GO:0086069)	10.9868274
100	keratinization (GO:0031424)	10.8855568

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	5.69878763
2	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	3.85775394
3	P63_26484246_Chip-Seq_KERATINOCYTES_Human	3.58208856
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.27210832
5	RARG_19884340_ChIP-ChIP_MEFs_Mouse	3.03282581
6	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.85141532
7	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	2.64214278
8	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	2.64214278
9	SOX9_24532713_ChIP-Seq_HFSC_Mouse	2.48570125
10	HIF1A_21447827_ChIP-Seq_MCF-7_Human	2.38678238
11	ESR2_21235772_ChIP-Seq_MCF-7_Human	2.06865882
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	15.3157000
13	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.83756984
14	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.82367890
15	TP63_22573176_ChIP-Seq_HFKS_Human	1.73570451
16	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.68275529
17	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.65515861
18	TP63_23658742_ChIP-Seq_EP156T_Human	1.65231880
19	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	1.57036794
20	SOX2_20726797_ChIP-Seq_SW620_Human	1.54727515
21	RACK7_27058665_Chip-Seq_MCF-7_Human	1.53334892
22	TP53_16413492_ChIP-PET_HCT116_Human	1.45949795
23	KLF5_25053715_ChIP-Seq_YYC3_Human	1.44917459
24	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.43618191
25	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.40618189
26	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.33680890
27	LXR_22292898_ChIP-Seq_THP-1_Human	1.32052731
28	ATF3_27146783_Chip-Seq_COLON_Human	1.31153987
29	CJUN_26792858_Chip-Seq_BT549_Human	1.29961099
30	AHR_22903824_ChIP-Seq_MCF-7_Human	1.27102362
31	RUNX1_27514584_Chip-Seq_MCF-7_Human	1.24366927
32	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.23584970
33	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.23028327
34	CTCF_27219007_Chip-Seq_Bcells_Human	1.21694889
35	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.21613002
36	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.20714095
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.18036556
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.16822937
39	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.15755445
40	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.13249941
41	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.13209499
42	ZNF263_19887448_ChIP-Seq_K562_Human	1.10862177
43	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	1.10034202
44	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.09883748
45	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.08580660
46	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	1.07066430
47	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.05942477
48	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.03053903
49	GATA6_25053715_ChIP-Seq_YYC3_Human	1.02020900
50	TP53_18474530_ChIP-ChIP_U2OS_Human	1.01943691
51	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00005603
52	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.99554106
53	TP53_22127205_ChIP-Seq_IMR90_Human	0.97825334
54	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.96990756
55	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96134766
56	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.95798687
57	EGR1_19032775_ChIP-ChIP_M12_Human	0.95049239
58	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.94927895
59	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	0.94075495
60	SMC4_20622854_ChIP-Seq_HELA_Human	0.92703547
61	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.91998314
62	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.91558165
63	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91034935
64	RXR_22108803_ChIP-Seq_LS180_Human	0.91004272
65	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.89087737
66	P300_27058665_Chip-Seq_ZR-75-30cells_Human	0.89055057
67	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.88667867
68	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.86952269
69	GATA4_25053715_ChIP-Seq_YYC3_Human	0.86583900
70	SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse	0.84044107
71	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.81386950
72	KDM2B_26808549_Chip-Seq_K562_Human	0.81255780
73	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	0.77707721
74	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.77252291
75	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.77021322
76	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.75220247
77	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.74517313
78	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.74433783
79	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.72168269
80	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.72004185
81	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.72004185
82	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.69571709
83	CREB1_26743006_Chip-Seq_LNCaP_Human	0.68523747
84	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.68296930
85	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.67922038
86	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.67422603
87	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.66650984
88	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.65551990
89	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.65537758
90	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.63483665
91	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	0.61732470
92	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.60784273
93	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.58301289
94	BCOR_27268052_Chip-Seq_Bcells_Human	0.58288043
95	GATA1_19941826_ChIP-Seq_K562_Human	0.58183267
96	CLOCK_20551151_ChIP-Seq_293T_Human	0.57624339
97	ZFP281_27345836_Chip-Seq_ESCs_Mouse	0.57076034
98	TCF7_22412390_ChIP-Seq_EML_Mouse	0.56983294
99	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.56484155
100	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.56282145

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	7.04607283
2	MP0010234_abnormal_vibrissa_follicle	6.36623955
3	MP0005275_abnormal_skin_tensile	5.58808409
4	MP0002796_impaired_skin_barrier	5.49515071
5	MP0005501_abnormal_skin_physiology	3.82191578
6	MP0003453_abnormal_keratinocyte_physiol	3.53924979
7	MP0002060_abnormal_skin_morphology	3.48727104
8	MP0010678_abnormal_skin_adnexa	3.42263898
9	MP0001216_abnormal_epidermal_layer	3.19961675
10	MP0003941_abnormal_skin_development	3.12246255
11	MP0000383_abnormal_hair_follicle	3.11392803
12	MP0000569_abnormal_digit_pigmentation	2.86152030
13	MP0010771_integument_phenotype	2.65584827
14	MP0000467_abnormal_esophagus_morphology	2.64129302
15	MP0004381_abnormal_hair_follicle	2.62460460
16	MP0002098_abnormal_vibrissa_morphology	2.58887638
17	MP0000762_abnormal_tongue_morphology	2.58557928
18	MP0005409_darkened_coat_color	2.46282555
19	MP0003705_abnormal_hypodermis_morpholog	2.41494610
20	MP0003566_abnormal_cell_adhesion	2.31004886
21	MP0004264_abnormal_extraembryonic_tissu	2.28542356
22	MP0000377_abnormal_hair_follicle	2.25231428
23	MP0000566_synostosis	2.12566341
24	MP0004272_abnormal_basement_membrane	2.01924732
25	MP0002234_abnormal_pharynx_morphology	1.92686562
26	MP0008438_abnormal_cutaneous_collagen	1.89411590
27	MP0005023_abnormal_wound_healing	1.80154836
28	MP0009053_abnormal_anal_canal	1.72172506
29	MP0002254_reproductive_system_inflammat	1.65327708
30	MP0004885_abnormal_endolymph	1.61969457
31	MP0000427_abnormal_hair_cycle	1.61730947
32	MP0001191_abnormal_skin_condition	1.44147111
33	MP0009931_abnormal_skin_appearance	1.41607849
34	MP0004043_abnormal_pH_regulation	1.37836953
35	MP0000367_abnormal_coat/_hair	1.31194502
36	MP0003787_abnormal_imprinting	1.27748711
37	MP0000003_abnormal_adipose_tissue	1.26418708
38	MP0004947_skin_inflammation	1.26072032
39	MP0001243_abnormal_dermal_layer	1.22028099
40	MP0003950_abnormal_plasma_membrane	1.19292577
41	MP0008260_abnormal_autophagy	1.18972232
42	MP0001299_abnormal_eye_distance/	1.15378217
43	MP0000013_abnormal_adipose_tissue	1.14871160
44	MP0005377_hearing/vestibular/ear_phenot	1.11614380
45	MP0003878_abnormal_ear_physiology	1.11614380
46	MP0001958_emphysema	1.04449829
47	MP0002282_abnormal_trachea_morphology	1.02688983
48	MP0000647_abnormal_sebaceous_gland	0.96868783
49	MP0009780_abnormal_chondrocyte_physiolo	0.96234943
50	MP0003191_abnormal_cellular_cholesterol	0.94944059
51	MP0004185_abnormal_adipocyte_glucose	0.94271638
52	MP0002089_abnormal_postnatal_growth/wei	0.94031518
53	MP0000678_abnormal_parathyroid_gland	0.93784948
54	MP0005076_abnormal_cell_differentiation	0.91930983
55	MP0004134_abnormal_chest_morphology	0.90572644
56	MP0004782_abnormal_surfactant_physiolog	0.83687689
57	MP0005375_adipose_tissue_phenotype	0.83281069
58	MP0001849_ear_inflammation	0.80994653
59	MP0003315_abnormal_perineum_morphology	0.71059592
60	MP0003123_paternal_imprinting	0.70011256
61	MP0005193_abnormal_anterior_eye	0.69289153
62	MP0001851_eye_inflammation	0.67385774
63	MP0001340_abnormal_eyelid_morphology	0.66511777
64	MP0000627_abnormal_mammary_gland	0.65633389
65	MP0002111_abnormal_tail_morphology	0.64068491
66	MP0006138_congestive_heart_failure	0.63833508
67	MP0005171_absent_coat_pigmentation	0.61449469
68	MP0003755_abnormal_palate_morphology	0.58666089
69	MP0010352_gastrointestinal_tract_polyps	0.56857983
70	MP0003385_abnormal_body_wall	0.55316241
71	MP0010030_abnormal_orbit_morphology	0.52853277
72	MP0001784_abnormal_fluid_regulation	0.48544299
73	MP0002877_abnormal_melanocyte_morpholog	0.47327093
74	MP0003786_premature_aging	0.47284004
75	MP0003638_abnormal_response/metabolism_	0.44879016
76	MP0003091_abnormal_cell_migration	0.44177930
77	MP0004197_abnormal_fetal_growth/weight/	0.42418296
78	MP0009379_abnormal_foot_pigmentation	0.42379353
79	MP0000639_abnormal_adrenal_gland	0.41025145
80	MP0002933_joint_inflammation	0.39176836
81	MP0002006_tumorigenesis	0.39141688
82	MP0002166_altered_tumor_susceptibility	0.38664436
83	MP0003045_fibrosis	0.35999715
84	MP0000432_abnormal_head_morphology	0.34289094
85	MP0002697_abnormal_eye_size	0.34045361
86	MP0002896_abnormal_bone_mineralization	0.33224561
87	MP0005257_abnormal_intraocular_pressure	0.33137460
88	MP0000470_abnormal_stomach_morphology	0.32998760
89	MP0002909_abnormal_adrenal_gland	0.32157036
90	MP0005666_abnormal_adipose_tissue	0.31301879
91	MP0000858_altered_metastatic_potential	0.29824280
92	MP0002295_abnormal_pulmonary_circulatio	0.27595878
93	MP0000538_abnormal_urinary_bladder	0.27392976
94	MP0005621_abnormal_cell_physiology	0.26550795
95	MP0002177_abnormal_outer_ear	0.26070699
96	MP0005451_abnormal_body_composition	0.25986366
97	MP0002095_abnormal_skin_pigmentation	0.25493297
98	MP0005503_abnormal_tendon_morphology	0.25056566
99	MP0002109_abnormal_limb_morphology	0.24154790
100	MP0009384_cardiac_valve_regurgitation	0.24094219

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of nail color (HP:0100643)	8.80402917
2	Fragile nails (HP:0001808)	7.42576683
3	Milia (HP:0001056)	7.42014806
4	Onycholysis (HP:0001806)	7.19071374
5	Plantar hyperkeratosis (HP:0007556)	6.79179935
6	Alopecia of scalp (HP:0002293)	6.14442245
7	Nonprogressive disorder (HP:0003680)	5.99511954
8	Right ventricular cardiomyopathy (HP:0011663)	5.77122783
9	Palmoplantar hyperkeratosis (HP:0000972)	5.41783717
10	Atrophic scars (HP:0001075)	5.41285537
11	Palmar hyperkeratosis (HP:0010765)	5.10206625
12	Thick nail (HP:0001805)	4.90208181
13	Nail dystrophy (HP:0008404)	4.39897736
14	Oral leukoplakia (HP:0002745)	4.20968936
15	Hypotrichosis (HP:0001006)	4.16113334
16	Hypoplastic pelvis (HP:0008839)	4.09763538
17	Dry hair (HP:0011359)	4.03401255
18	Increased IgE level (HP:0003212)	3.86887797
19	Sparse scalp hair (HP:0002209)	3.77271656
20	Woolly hair (HP:0002224)	3.76189048
21	Erythroderma (HP:0001019)	3.47924933
22	Corneal dystrophy (HP:0001131)	3.46531894
23	Cervical subluxation (HP:0003308)	3.43321875
24	Hypoplastic ischia (HP:0003175)	3.37290415
25	Congenital ichthyosiform erythroderma (HP:0007431)	3.33105053
26	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	3.27030552
27	Abnormal blistering of the skin (HP:0008066)	3.25600518
28	Ectropion (HP:0000656)	3.17225743
29	Corneal erosion (HP:0200020)	3.10267641
30	Fragile skin (HP:0001030)	3.02871120
31	Erythema (HP:0010783)	3.00355498
32	Abnormality of secondary sexual hair (HP:0009888)	2.94501501
33	Abnormality of the axillary hair (HP:0100134)	2.94501501
34	Flat acetabular roof (HP:0003180)	2.92119349
35	Ridged nail (HP:0001807)	2.89250572
36	Neonatal short-limb short stature (HP:0008921)	2.88081743
37	Abnormality of the ischium (HP:0003174)	2.80446378
38	Natal tooth (HP:0000695)	2.79892200
39	Pili torti (HP:0003777)	2.79770670
40	Hypoplasia of dental enamel (HP:0006297)	2.79185643
41	Epiphyseal dysplasia (HP:0002656)	2.78274051
42	Lip pit (HP:0100267)	2.77988420
43	Follicular hyperkeratosis (HP:0007502)	2.76337809
44	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.75876589
45	Sparse eyelashes (HP:0000653)	2.62243050
46	Vertebral clefting (HP:0008428)	2.59607213
47	Entropion (HP:0000621)	2.59143395
48	Anonychia (HP:0001798)	2.48897696
49	Abnormality of placental membranes (HP:0011409)	2.46722644
50	Amniotic constriction ring (HP:0009775)	2.46722644
51	Parakeratosis (HP:0001036)	2.39610135
52	Poikiloderma (HP:0001029)	2.37024051
53	Abnormal hair laboratory examination (HP:0003328)	2.36819125
54	Flat capital femoral epiphysis (HP:0003370)	2.36227629
55	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.31309669
56	Palmoplantar keratoderma (HP:0000982)	2.29559623
57	Squamous cell carcinoma (HP:0002860)	2.21169470
58	Mixed hearing impairment (HP:0000410)	2.20533470
59	Abnormal vertebral ossification (HP:0100569)	2.15231863
60	Vitreoretinal degeneration (HP:0000655)	2.11138657
61	Aplasia cutis congenita (HP:0001057)	2.08686214
62	Malnutrition (HP:0004395)	2.08595019
63	Blepharitis (HP:0000498)	2.07402485
64	Absent eyelashes (HP:0000561)	2.06481026
65	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.06323557
66	Absent epiphyses (HP:0010577)	2.06323557
67	Ventricular tachycardia (HP:0004756)	2.06312350
68	Hypoplastic labia majora (HP:0000059)	2.04325473
69	Carious teeth (HP:0000670)	2.02504123
70	Protuberant abdomen (HP:0001538)	2.02238412
71	Hypohidrosis (HP:0000966)	1.92495805
72	Decreased lacrimation (HP:0000633)	1.92490628
73	Pterygium (HP:0001059)	1.90842024
74	Advanced eruption of teeth (HP:0006288)	1.90569977
75	Abnormality of the salivary glands (HP:0010286)	1.90481193
76	Fatigable weakness (HP:0003473)	1.90129586
77	Abnormality of the neuromuscular junction (HP:0003398)	1.90129586
78	Duplicated collecting system (HP:0000081)	1.89331650
79	Acanthosis nigricans (HP:0000956)	1.88789487
80	Hypoplasia of the iris (HP:0007676)	1.87358715
81	Increased connective tissue (HP:0009025)	1.85481917
82	Hip contracture (HP:0003273)	1.84393817
83	Selective tooth agenesis (HP:0001592)	1.83081676
84	Hyperhidrosis (HP:0000975)	1.82701919
85	Pustule (HP:0200039)	1.82602627
86	Abnormality of the labia majora (HP:0012881)	1.81845038
87	Abnormal auditory evoked potentials (HP:0006958)	1.81342673
88	Short nail (HP:0001799)	1.77939686
89	Amelogenesis imperfecta (HP:0000705)	1.77159079
90	Brittle hair (HP:0002299)	1.76036821
91	Delayed epiphyseal ossification (HP:0002663)	1.75793578
92	Limited hip movement (HP:0008800)	1.75345641
93	Metaphyseal cupping (HP:0003021)	1.74938973
94	Laryngomalacia (HP:0001601)	1.74694833
95	Hypodontia (HP:0000668)	1.73951726
96	Severe short stature (HP:0003510)	1.73484108
97	Flattened epiphyses (HP:0003071)	1.72560605
98	Popliteal pterygium (HP:0009756)	1.71145695
99	Down-sloping shoulders (HP:0200021)	1.70787619
100	Furrowed tongue (HP:0000221)	1.70712996

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MST1R	5.39383033
2	EPHA2	5.28458783
3	DDR2	4.34221759
4	MAPK15	4.19762849
5	STK24	3.94604083
6	WNK1	3.44387996
7	MAP3K6	3.28334581
8	MET	3.22469487
9	EPHB2	2.61665654
10	MAP3K2	2.42505091
11	MST4	2.34241598
12	PBK	2.25979701
13	STK38L	1.90271331
14	PKN2	1.86977913
15	TLK1	1.79807840
16	NME2	1.71512345
17	PTK2	1.70271248
18	LATS1	1.69124660
19	NTRK1	1.50673457
20	PDGFRB	1.49347429
21	MAP3K12	1.48449315
22	SIK1	1.33154732
23	PRKD2	1.32767012
24	MAP3K3	1.28673452
25	TRIB3	1.23576992
26	TGFBR2	1.21354803
27	RIPK1	1.12224136
28	FLT3	1.11140735
29	ABL2	1.08370915
30	ERBB2	1.06627095
31	TESK1	1.06019450
32	TGFBR1	1.00653860
33	FER	0.99696633
34	PIM2	0.97647121
35	NME1	0.94926720
36	STK10	0.91235495
37	CSK	0.89253556
38	MAP3K9	0.87145130
39	TRPM7	0.84663795
40	CDC42BPA	0.84533384
41	MAPKAPK5	0.84301264
42	MAPKAPK3	0.80014464
43	ARAF	0.79332960
44	MAPK7	0.77449909
45	BMX	0.70950278
46	MYLK	0.70683851
47	LATS2	0.69581029
48	CDK12	0.69323650
49	STK3	0.68496493
50	GRK7	0.66307162
51	STK38	0.65893626
52	PRKCI	0.65064539
53	PTK6	0.64309601
54	DAPK2	0.63880756
55	PHKG1	0.62046169
56	PHKG2	0.62046169
57	RPS6KA2	0.60541276
58	ADRBK1	0.59263103
59	MAP2K6	0.59204192
60	PDGFRA	0.58633495
61	TBK1	0.56894342
62	DAPK3	0.53957207
63	MOS	0.53251075
64	MAP3K1	0.52583026
65	ERN1	0.51430599
66	ILK	0.51010263
67	MTOR	0.50750855
68	DMPK	0.50542997
69	RET	0.48511110
70	MATK	0.48294034
71	STK16	0.46486285
72	RPS6KL1	0.45973310
73	RPS6KC1	0.45973310
74	DAPK1	0.41156235
75	PAK4	0.41078188
76	NEK9	0.40587804
77	RPS6KA6	0.40056065
78	MAPKAPK2	0.37998273
79	IKBKB	0.36496873
80	EPHA4	0.34331933
81	IRAK2	0.33318285
82	FGR	0.32971705
83	ROCK1	0.32765138
84	GSK3A	0.32024975
85	IGF1R	0.31215703
86	SGK223	0.29458949
87	SGK494	0.29458949
88	ABL1	0.26479724
89	PRKD1	0.25566528
90	ROCK2	0.25119750
91	FGFR1	0.23577185
92	CHUK	0.22197878
93	MARK2	0.21474592
94	TAOK1	0.21228599
95	TTN	0.20444344
96	PTK2B	0.19399547
97	GRK6	0.19108154
98	INSR	0.19038573
99	BCR	0.14907585
100	RPS6KA1	0.13509189

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ECM-receptor interaction_Homo sapiens_hsa04512	5.01851975
2	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.23485217
3	Protein digestion and absorption_Homo sapiens_hsa04974	3.02223104
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.82354949
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.61894995
6	Focal adhesion_Homo sapiens_hsa04510	2.57080658
7	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	2.10420787
8	Basal cell carcinoma_Homo sapiens_hsa05217	2.07459660
9	Amoebiasis_Homo sapiens_hsa05146	2.06949868
10	Small cell lung cancer_Homo sapiens_hsa05222	2.06126194
11	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.05850660
12	Sphingolipid metabolism_Homo sapiens_hsa00600	2.03162182
13	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.99769602
14	Bladder cancer_Homo sapiens_hsa05219	1.89039074
15	Ether lipid metabolism_Homo sapiens_hsa00565	1.80163623
16	p53 signaling pathway_Homo sapiens_hsa04115	1.69237137
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62322485
18	VEGF signaling pathway_Homo sapiens_hsa04370	1.45092762
19	Proteoglycans in cancer_Homo sapiens_hsa05205	1.43468026
20	GnRH signaling pathway_Homo sapiens_hsa04912	1.41794084
21	Adherens junction_Homo sapiens_hsa04520	1.36688517
22	Axon guidance_Homo sapiens_hsa04360	1.32916735
23	Tight junction_Homo sapiens_hsa04530	1.29833441
24	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.27224821
25	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.26799132
26	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	1.26426654
27	Hippo signaling pathway_Homo sapiens_hsa04390	1.21883036
28	ErbB signaling pathway_Homo sapiens_hsa04012	1.21461667
29	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	1.20297084
30	Galactose metabolism_Homo sapiens_hsa00052	1.19803172
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.16929901
32	Pathways in cancer_Homo sapiens_hsa05200	1.16074559
33	Renal cell carcinoma_Homo sapiens_hsa05211	1.13966055
34	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.12232648
35	Melanogenesis_Homo sapiens_hsa04916	1.07085603
36	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.05765775
37	Toxoplasmosis_Homo sapiens_hsa05145	0.99605895
38	MicroRNAs in cancer_Homo sapiens_hsa05206	0.98600865
39	Endocytosis_Homo sapiens_hsa04144	0.98191881
40	Notch signaling pathway_Homo sapiens_hsa04330	0.97377819
41	Arginine biosynthesis_Homo sapiens_hsa00220	0.97284450
42	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96626591
43	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.95590906
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93586146
45	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.92760231
46	Salmonella infection_Homo sapiens_hsa05132	0.91012735
47	Other glycan degradation_Homo sapiens_hsa00511	0.89171064
48	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.86406082
49	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.83690194
50	Glioma_Homo sapiens_hsa05214	0.83240504
51	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.83234428
52	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.82591912
53	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.79522076
54	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.79044754
55	PPAR signaling pathway_Homo sapiens_hsa03320	0.76882745
56	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.74062591
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73669970
58	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.73636689
59	Phototransduction_Homo sapiens_hsa04744	0.72776212
60	Shigellosis_Homo sapiens_hsa05131	0.70681646
61	Choline metabolism in cancer_Homo sapiens_hsa05231	0.70593001
62	Ras signaling pathway_Homo sapiens_hsa04014	0.69196832
63	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.67978115
64	Acute myeloid leukemia_Homo sapiens_hsa05221	0.65230510
65	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.63990456
66	Lysosome_Homo sapiens_hsa04142	0.63515978
67	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.62627864
68	Renin secretion_Homo sapiens_hsa04924	0.62553258
69	Hepatitis C_Homo sapiens_hsa05160	0.61717558
70	Wnt signaling pathway_Homo sapiens_hsa04310	0.59443537
71	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.58931593
72	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.58829335
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58474540
74	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.58020778
75	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.54799192
76	Thyroid cancer_Homo sapiens_hsa05216	0.54518915
77	Long-term depression_Homo sapiens_hsa04730	0.54291411
78	Malaria_Homo sapiens_hsa05144	0.54264223
79	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.53938145
80	Insulin signaling pathway_Homo sapiens_hsa04910	0.51970364
81	Rap1 signaling pathway_Homo sapiens_hsa04015	0.51417088
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50262635
83	Estrogen signaling pathway_Homo sapiens_hsa04915	0.47547851
84	MAPK signaling pathway_Homo sapiens_hsa04010	0.47194859
85	Mineral absorption_Homo sapiens_hsa04978	0.46179756
86	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.45790833
87	Insulin resistance_Homo sapiens_hsa04931	0.41658866
88	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.39147643
89	Prolactin signaling pathway_Homo sapiens_hsa04917	0.38990137
90	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.38631583
91	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.38130462
92	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.37916750
93	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37560513
94	Pancreatic cancer_Homo sapiens_hsa05212	0.37208432
95	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.36468248
96	Salivary secretion_Homo sapiens_hsa04970	0.35646038
97	Steroid biosynthesis_Homo sapiens_hsa00100	0.35299007
98	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.34456589
99	Melanoma_Homo sapiens_hsa05218	0.32843329
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.32122433

KRT16P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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