KRT17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)9.15985110
2regulation of water loss via skin (GO:0033561)8.48166354
3bundle of His cell to Purkinje myocyte communication (GO:0086069)8.30791232
4peptide cross-linking (GO:0018149)7.43898633
5* intermediate filament organization (GO:0045109)7.31084484
6keratinocyte differentiation (GO:0030216)7.10843787
7* epidermis development (GO:0008544)6.15532281
8surfactant homeostasis (GO:0043129)5.86732636
9multicellular organismal water homeostasis (GO:0050891)5.79152503
10epidermal cell differentiation (GO:0009913)5.64125548
11negative regulation of keratinocyte proliferation (GO:0010839)5.39437061
12gap junction assembly (GO:0016264)5.02998698
13skin morphogenesis (GO:0043589)4.97947739
14keratinocyte development (GO:0003334)4.90547627
15chemical homeostasis within a tissue (GO:0048875)4.87092902
16water homeostasis (GO:0030104)4.81594719
17polarized epithelial cell differentiation (GO:0030859)4.67319060
18epithelial cell differentiation involved in prostate gland development (GO:0060742)4.67163974
19detection of bacterium (GO:0016045)4.51970034
20* intermediate filament cytoskeleton organization (GO:0045104)4.50280177
21cell adhesion mediated by integrin (GO:0033627)4.44577367
22* intermediate filament-based process (GO:0045103)4.33259742
23positive regulation of keratinocyte differentiation (GO:0045618)4.27660879
24ectoderm development (GO:0007398)4.17291569
25regulation of ruffle assembly (GO:1900027)4.11391451
26negative regulation of cell fate specification (GO:0009996)4.04691177
27regulation of phospholipase A2 activity (GO:0032429)4.01764625
28virion attachment to host cell (GO:0019062)4.01675435
29adhesion of symbiont to host cell (GO:0044650)4.01675435
30planar cell polarity pathway involved in neural tube closure (GO:0090179)4.00839429
31protein localization to endosome (GO:0036010)3.91900662
32regulation of chemokine secretion (GO:0090196)3.91814165
33keratinocyte proliferation (GO:0043616)3.90817410
34detection of other organism (GO:0098543)3.83479200
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.76595041
36endodermal cell differentiation (GO:0035987)3.71522345
37mesodermal cell differentiation (GO:0048333)3.71324887
38negative regulation of epidermis development (GO:0045683)3.67840420
39negative regulation of chondrocyte differentiation (GO:0032331)3.65646912
40sphingoid metabolic process (GO:0046519)3.64420887
41hypotonic response (GO:0006971)3.60801775
42cell junction assembly (GO:0034329)3.59841472
43phospholipid scrambling (GO:0017121)3.58910732
44interferon-gamma secretion (GO:0072643)3.51327728
45hair follicle morphogenesis (GO:0031069)3.46134327
46negative regulation of cell fate commitment (GO:0010454)3.44900384
47eyelid development in camera-type eye (GO:0061029)3.43431477
48cell junction organization (GO:0034330)3.41212058
49cell-substrate junction assembly (GO:0007044)3.39575355
50L-serine transport (GO:0015825)3.38563324
51cell-substrate adherens junction assembly (GO:0007045)3.37842178
52focal adhesion assembly (GO:0048041)3.37842178
53* regulation of hair follicle development (GO:0051797)3.37001435
54lymph vessel development (GO:0001945)3.33369522
55fatty acid elongation (GO:0030497)3.28596865
56atrioventricular valve morphogenesis (GO:0003181)3.28447577
57regulation of natural killer cell differentiation (GO:0032823)3.28077437
58non-canonical Wnt signaling pathway (GO:0035567)3.27017500
59diol metabolic process (GO:0034311)3.25112028
60morphogenesis of embryonic epithelium (GO:0016331)3.25077415
61adhesion of symbiont to host (GO:0044406)3.20872569
62skin development (GO:0043588)3.19154756
63regulation of glomerular filtration (GO:0003093)3.18866771
64positive regulation of Cdc42 GTPase activity (GO:0043089)3.17602459
65molting cycle process (GO:0022404)3.15413021
66hair cycle process (GO:0022405)3.15413021
67gland morphogenesis (GO:0022612)3.15065850
68G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.14718340
69regulation of transforming growth factor beta2 production (GO:0032909)3.14169987
70regulation of somitogenesis (GO:0014807)3.13096606
71establishment of planar polarity (GO:0001736)3.13041330
72establishment of tissue polarity (GO:0007164)3.13041330
73* epithelium development (GO:0060429)3.11956466
74ventricular cardiac muscle cell action potential (GO:0086005)3.10322535
75response to phenylpropanoid (GO:0080184)3.08196162
76regulation of epidermal growth factor-activated receptor activity (GO:0007176)3.06629388
77phosphatidylserine acyl-chain remodeling (GO:0036150)3.03120284
78regulation of keratinocyte proliferation (GO:0010837)3.02668453
79renal filtration (GO:0097205)2.99105549
80G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.97974958
81regulation of secondary heart field cardioblast proliferation (GO:0003266)2.96299105
82regulation of cardioblast proliferation (GO:0003264)2.96299105
83sphingosine metabolic process (GO:0006670)2.94366693
84membrane tubulation (GO:0097320)2.94148820
85negative regulation of stress fiber assembly (GO:0051497)2.93152997
86hair follicle development (GO:0001942)2.88861769
87serine transport (GO:0032329)2.88813654
88adherens junction assembly (GO:0034333)2.88118055
89phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84769561
90cardiac right ventricle morphogenesis (GO:0003215)2.82630943
91regulation of endothelial cell chemotaxis (GO:2001026)2.81492148
92adherens junction organization (GO:0034332)2.79290621
93positive regulation of interleukin-8 secretion (GO:2000484)2.78419982
94positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.77689121
95intestinal epithelial cell development (GO:0060576)2.77365391
96positive regulation of protein export from nucleus (GO:0046827)2.76416339
97regulation of cardioblast differentiation (GO:0051890)2.75480088
98ephrin receptor signaling pathway (GO:0048013)2.74699868
99renal system development (GO:0072001)2.71668927
100regulation of cell proliferation involved in kidney development (GO:1901722)2.70278182
101regulation of transforming growth factor beta production (GO:0071634)2.69832990
102mammary gland epithelial cell proliferation (GO:0033598)2.69584498
103positive regulation of epidermal cell differentiation (GO:0045606)2.69167164
104* regulation of hair cycle (GO:0042634)2.68496168
105regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.68413914
106regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.68272183
107renal absorption (GO:0070293)2.68231045
108negative regulation of interferon-gamma production (GO:0032689)2.66178647
109positive regulation of actin filament depolymerization (GO:0030836)2.65476333
110* positive regulation of epidermis development (GO:0045684)2.62952995
111regulation of heart rate by cardiac conduction (GO:0086091)2.62798147
112regulation of keratinocyte differentiation (GO:0045616)2.60944573
113regulation of Cdc42 GTPase activity (GO:0043088)2.60720093
114* regulation of epidermis development (GO:0045682)2.60553802
115cell communication involved in cardiac conduction (GO:0086065)2.59563312
116endosome organization (GO:0007032)2.58801675
117regulation of transforming growth factor beta1 production (GO:0032908)2.58472126
118response to UV-B (GO:0010224)2.57609971
119lateral sprouting from an epithelium (GO:0060601)2.57013444
120positive regulation of cholesterol efflux (GO:0010875)2.56829606
121renal system process involved in regulation of blood volume (GO:0001977)2.54851661
122negative regulation of kidney development (GO:0090185)2.53407593
123wound healing (GO:0042060)2.51724433
124epithelial cell-cell adhesion (GO:0090136)2.51445214
125activation of Rac GTPase activity (GO:0032863)2.51373581
126odontogenesis (GO:0042476)2.51256402
127positive regulation of monocyte chemotaxis (GO:0090026)2.50719213
128embryonic camera-type eye development (GO:0031076)2.49595917
129regulation of epidermal cell differentiation (GO:0045604)2.49465576
130dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.48695550
131extracellular matrix disassembly (GO:0022617)2.47902783
132cellular copper ion homeostasis (GO:0006878)2.47001590
133positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.45777706
134negative regulation of cartilage development (GO:0061037)2.45486109
135negative regulation of interleukin-2 production (GO:0032703)2.44440196
136negative regulation of stem cell proliferation (GO:2000647)2.44319035
137phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.43481311
138cytoskeletal anchoring at plasma membrane (GO:0007016)2.42033142
139positive regulation of Rho protein signal transduction (GO:0035025)2.41591455
140negative regulation of lipase activity (GO:0060192)2.41504362
141epithelial cell proliferation (GO:0050673)2.40580491
142desmosome organization (GO:0002934)14.0411766
143molting cycle (GO:0042303)13.6082521
144hair cycle (GO:0042633)13.6082521
145* keratinization (GO:0031424)11.2992377
146hemidesmosome assembly (GO:0031581)10.2334471

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.83631601
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.30915820
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.63989576
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.51573495
5* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.25783235
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.25725406
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.09081723
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.08855297
9TP63_17297297_ChIP-ChIP_HaCaT_Human15.1618248
10* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.92806626
11* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.92806626
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90498737
13FOXO3_23340844_ChIP-Seq_DLD1_Human1.60668414
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40836362
15ZNF263_19887448_ChIP-Seq_K562_Human1.37921952
16RACK7_27058665_Chip-Seq_MCF-7_Human1.36469490
17TP53_20018659_ChIP-ChIP_R1E_Mouse1.36215468
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35296082
19* SOX2_20726797_ChIP-Seq_SW620_Human1.34348687
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28349919
21KLF5_25053715_ChIP-Seq_YYC3_Human1.27882478
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27656643
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.26279094
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25810806
25LXR_22292898_ChIP-Seq_THP-1_Human1.25208771
26BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.24176679
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.23832624
28EGR1_19032775_ChIP-ChIP_M12_Human1.23822616
29TP63_23658742_ChIP-Seq_EP156T_Human1.20833626
30TCF4_18268006_ChIP-ChIP_LS174T_Human1.19203137
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.18243055
32* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.17191244
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16481749
34CJUN_26792858_Chip-Seq_BT549_Human1.16195627
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16184903
36AHR_22903824_ChIP-Seq_MCF-7_Human1.16136517
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15280503
38UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15220407
39ATF3_27146783_Chip-Seq_COLON_Human1.12882349
40TP63_22573176_ChIP-Seq_HFKS_Human1.11983540
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.11926330
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10088845
43* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09273931
44HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09066282
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07523321
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05549433
47* TP53_18474530_ChIP-ChIP_U2OS_Human1.04978856
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04824412
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02710350
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00830898
51* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00637931
52CTCF_27219007_Chip-Seq_Bcells_Human1.00570071
53UBF1/2_26484160_Chip-Seq_HMECs_Human0.99616160
54RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99378120
55EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99378120
56EZH2_27294783_Chip-Seq_ESCs_Mouse0.98751976
57EED_16625203_ChIP-ChIP_MESCs_Mouse0.98688621
58* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.98205863
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98175406
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96794394
61SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96703322
62GATA3_24758297_ChIP-Seq_MCF-7_Human0.95723100
63CDX2_20551321_ChIP-Seq_CACO-2_Human0.95352823
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93599410
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92677057
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90543752
67ARNT_22903824_ChIP-Seq_MCF-7_Human0.89933252
68EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89923275
69DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88478425
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.88436260
71TP53_22127205_ChIP-Seq_IMR90_Human0.88108321
72GATA4_25053715_ChIP-Seq_YYC3_Human0.88104284
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.87792720
74CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87491012
75ELK3_25401928_ChIP-Seq_HUVEC_Human0.87397032
76STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86505478
77RING1B_27294783_Chip-Seq_ESCs_Mouse0.85743888
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85683530
79AR_21572438_ChIP-Seq_LNCaP_Human0.85205855
80GATA6_25053715_ChIP-Seq_YYC3_Human0.83758290
81JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83700517
82SA1_27219007_Chip-Seq_ERYTHROID_Human0.83192127
83RXR_22108803_ChIP-Seq_LS180_Human0.82045425
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81663164
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.81081541
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80904480
87RING1B_27294783_Chip-Seq_NPCs_Mouse0.80870716
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80066477
89AR_21909140_ChIP-Seq_LNCAP_Human0.79262184
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.78978029
91TP53_16413492_ChIP-PET_HCT116_Human0.78943240
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.77940607
93NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77187853
94KDM2B_26808549_Chip-Seq_K562_Human0.76801857
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.75065094
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.74593114
97MTF2_20144788_ChIP-Seq_MESCs_Mouse0.74509015
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74220525
99CLOCK_20551151_ChIP-Seq_293T_Human0.74215651
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.74201170
101TBX20_22080862_ChIP-Seq_HEART_Mouse0.74201170
102GATA2_21666600_ChIP-Seq_HMVEC_Human0.73700455
103KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72885230
104P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72816710
105SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72479651
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.71586181
107TET1_21490601_ChIP-Seq_MESCs_Mouse0.71247608
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.71220870
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70828000
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.70083231
111* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.69679982
112PPAR_26484153_Chip-Seq_NCI-H1993_Human0.68908308
113* BCOR_27268052_Chip-Seq_Bcells_Human0.67806059
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67700011
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.67609950
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.67091773
117JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.63335438
118KDM2B_26808549_Chip-Seq_SUP-B15_Human0.63254024
119NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.63056555
120RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.62706284
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62319539
122NANOG_18555785_ChIP-Seq_MESCs_Mouse0.61850739
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61549041
124* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61164110
125* SMC4_20622854_ChIP-Seq_HELA_Human0.61135135
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.61104678
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.60935840
128CSB_26484114_Chip-Seq_FIBROBLAST_Human0.60799340
129TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.58314251
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.56806678
131ZFP281_18757296_ChIP-ChIP_E14_Mouse0.54663620
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54128652
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.52825203
134CHD1_26751641_Chip-Seq_LNCaP_Human0.52367370
135ELK4_26923725_Chip-Seq_MESODERM_Mouse0.52314849
136CREB1_26743006_Chip-Seq_LNCaP_Human0.51334512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.66508752
2* MP0000579_abnormal_nail_morphology5.47227989
3MP0010234_abnormal_vibrissa_follicle4.55228620
4MP0002254_reproductive_system_inflammat4.52824267
5MP0005275_abnormal_skin_tensile4.49686409
6MP0005501_abnormal_skin_physiology4.14233800
7MP0003941_abnormal_skin_development3.64005761
8* MP0002098_abnormal_vibrissa_morphology3.60009676
9MP0003705_abnormal_hypodermis_morpholog3.48409762
10MP0001216_abnormal_epidermal_layer3.43132508
11MP0002060_abnormal_skin_morphology3.30585129
12MP0000647_abnormal_sebaceous_gland3.24083911
13MP0000383_abnormal_hair_follicle3.19570332
14MP0000467_abnormal_esophagus_morphology3.05315398
15MP0003453_abnormal_keratinocyte_physiol2.99292474
16MP0010678_abnormal_skin_adnexa2.99003875
17* MP0000377_abnormal_hair_follicle2.70577723
18MP0010771_integument_phenotype2.67742808
19MP0001346_abnormal_lacrimal_gland2.56086849
20* MP0000762_abnormal_tongue_morphology2.42995686
21* MP0004381_abnormal_hair_follicle2.23874087
22MP0003566_abnormal_cell_adhesion2.09102556
23MP0004947_skin_inflammation2.07873993
24MP0005451_abnormal_body_composition1.98997886
25* MP0000427_abnormal_hair_cycle1.97484781
26MP0009053_abnormal_anal_canal1.89363136
27MP0001243_abnormal_dermal_layer1.88022253
28MP0010030_abnormal_orbit_morphology1.76699613
29MP0000566_synostosis1.74545209
30MP0002234_abnormal_pharynx_morphology1.68599073
31MP0009931_abnormal_skin_appearance1.54392900
32MP0002009_preneoplasia1.54265114
33MP0008260_abnormal_autophagy1.52053605
34* MP0000367_abnormal_coat/_hair1.50810508
35MP0001191_abnormal_skin_condition1.47239985
36MP0008789_abnormal_olfactory_epithelium1.47096819
37MP0000516_abnormal_urinary_system1.46774523
38MP0005367_renal/urinary_system_phenotyp1.46774523
39MP0002877_abnormal_melanocyte_morpholog1.32902032
40MP0001851_eye_inflammation1.31567144
41MP0001849_ear_inflammation1.27980616
42MP0003315_abnormal_perineum_morphology1.23741379
43MP0000465_gastrointestinal_hemorrhage1.15606076
44MP0005360_urolithiasis1.13972608
45MP0005257_abnormal_intraocular_pressure1.09108537
46MP0005409_darkened_coat_color1.06503304
47MP0000537_abnormal_urethra_morphology1.06008787
48MP0002249_abnormal_larynx_morphology1.04837506
49MP0001340_abnormal_eyelid_morphology1.03228641
50MP0004264_abnormal_extraembryonic_tissu0.98839006
51MP0005499_abnormal_olfactory_system0.96970565
52MP0005394_taste/olfaction_phenotype0.96970565
53MP0002282_abnormal_trachea_morphology0.96048206
54MP0000678_abnormal_parathyroid_gland0.93789219
55MP0004272_abnormal_basement_membrane0.93282525
56MP0005023_abnormal_wound_healing0.88191898
57MP0000627_abnormal_mammary_gland0.83510880
58MP0002233_abnormal_nose_morphology0.80907596
59MP0000858_altered_metastatic_potential0.80686488
60MP0005076_abnormal_cell_differentiation0.74507528
61* MP0003755_abnormal_palate_morphology0.73797906
62MP0002166_altered_tumor_susceptibility0.71328781
63MP0000685_abnormal_immune_system0.70311578
64MP0002006_tumorigenesis0.69828916
65MP0004858_abnormal_nervous_system0.69334160
66MP0000013_abnormal_adipose_tissue0.67745514
67MP0010352_gastrointestinal_tract_polyps0.66790753
68MP0000538_abnormal_urinary_bladder0.63578124
69MP0003763_abnormal_thymus_physiology0.63345613
70MP0000003_abnormal_adipose_tissue0.62991539
71MP0003091_abnormal_cell_migration0.62664987
72MP0004185_abnormal_adipocyte_glucose0.61927126
73MP0003045_fibrosis0.61917410
74MP0009250_abnormal_appendicular_skeleto0.61250406
75MP0000613_abnormal_salivary_gland0.60149700
76MP0004019_abnormal_vitamin_homeostasis0.59175544
77MP0003828_pulmonary_edema0.55209357
78MP0003385_abnormal_body_wall0.54479098
79MP0005197_abnormal_uvea_morphology0.53941137
80MP0001299_abnormal_eye_distance/0.53909740
81MP0003191_abnormal_cellular_cholesterol0.53669745
82MP0009780_abnormal_chondrocyte_physiolo0.53340308
83MP0009379_abnormal_foot_pigmentation0.53326122
84MP0000470_abnormal_stomach_morphology0.53087534
85MP0005193_abnormal_anterior_eye0.52310648
86MP0001542_abnormal_bone_strength0.50764570
87MP0003011_delayed_dark_adaptation0.50397472
88MP0005508_abnormal_skeleton_morphology0.49272011
89MP0002111_abnormal_tail_morphology0.49176743
90MP0001661_extended_life_span0.49077320
91MP0003806_abnormal_nucleotide_metabolis0.48163968
92MP0003329_amyloid_beta_deposits0.47520403
93MP0002089_abnormal_postnatal_growth/wei0.47056512
94MP0000049_abnormal_middle_ear0.47039657
95MP0002177_abnormal_outer_ear0.46910745
96MP0001348_abnormal_lacrimal_gland0.46745446
97MP0001784_abnormal_fluid_regulation0.46344993
98MP0005375_adipose_tissue_phenotype0.43525116
99MP0005248_abnormal_Harderian_gland0.43247441
100MP0009840_abnormal_foam_cell0.42506855
101MP0005621_abnormal_cell_physiology0.42209800
102MP0002095_abnormal_skin_pigmentation0.42176696
103MP0004197_abnormal_fetal_growth/weight/0.41944469
104MP0003300_gastrointestinal_ulcer0.41794658
105MP0003950_abnormal_plasma_membrane0.40997956
106MP0002697_abnormal_eye_size0.38693654
107MP0003638_abnormal_response/metabolism_0.38392997
108MP0004782_abnormal_surfactant_physiolog0.38385202
109MP0000750_abnormal_muscle_regeneration0.37906935
110MP0000733_abnormal_muscle_development0.37703128
111MP0003724_increased_susceptibility_to0.37181609
112MP0003786_premature_aging0.36729415
113MP0008438_abnormal_cutaneous_collagen0.36443317
114MP0006138_congestive_heart_failure0.35615338
115MP0000432_abnormal_head_morphology0.34710464
116MP0002896_abnormal_bone_mineralization0.33869225
117MP0001853_heart_inflammation0.33599096
118MP0003448_altered_tumor_morphology0.33006358
119MP0000462_abnormal_digestive_system0.32411328
120MP0005330_cardiomyopathy0.32312651
121MP0005164_abnormal_response_to0.31712987
122MP0005623_abnormal_meninges_morphology0.29420489
123MP0010368_abnormal_lymphatic_system0.29178936
124MP0003936_abnormal_reproductive_system0.28757805
125MP0009384_cardiac_valve_regurgitation0.28514002
126MP0004885_abnormal_endolymph0.27422235
127MP0000534_abnormal_ureter_morphology0.25772747
128MP0003942_abnormal_urinary_system0.25536590
129MP0005390_skeleton_phenotype0.25141222

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)7.82569936
2Woolly hair (HP:0002224)7.47205082
3Milia (HP:0001056)7.38734518
4Fragile nails (HP:0001808)6.85870760
5Right ventricular cardiomyopathy (HP:0011663)6.83646981
6* Plantar hyperkeratosis (HP:0007556)6.67258194
7* Abnormality of nail color (HP:0100643)6.55036980
8Onycholysis (HP:0001806)6.01157346
9* Palmoplantar hyperkeratosis (HP:0000972)5.91824380
10Thick nail (HP:0001805)5.73065743
11Pili torti (HP:0003777)5.62951342
12* Palmar hyperkeratosis (HP:0010765)5.54697710
13Lip pit (HP:0100267)5.49180198
14Increased IgE level (HP:0003212)5.38139109
15Parakeratosis (HP:0001036)5.13669579
16* Nail dystrophy (HP:0008404)5.01536047
17Atrophic scars (HP:0001075)4.75576936
18Alopecia of scalp (HP:0002293)4.41210537
19* Abnormal blistering of the skin (HP:0008066)4.12068330
20Erythema (HP:0010783)4.05231752
21Sparse eyelashes (HP:0000653)3.88361656
22Selective tooth agenesis (HP:0001592)3.79373762
23Abnormal hair laboratory examination (HP:0003328)3.77369682
24* Natal tooth (HP:0000695)3.70012786
25Follicular hyperkeratosis (HP:0007502)3.67180616
26Congenital ichthyosiform erythroderma (HP:0007431)3.59041620
27Ventricular tachycardia (HP:0004756)3.51878901
28Ridged nail (HP:0001807)3.51409059
29Hypoplastic labia majora (HP:0000059)3.32843935
30Aplasia cutis congenita (HP:0001057)3.17046469
31Fragile skin (HP:0001030)3.12696579
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.07165803
33* Advanced eruption of teeth (HP:0006288)3.06806418
34Erythroderma (HP:0001019)3.03838770
35Abnormality of the labia majora (HP:0012881)3.03041166
36Brittle hair (HP:0002299)2.98527720
37Abnormality of placental membranes (HP:0011409)2.95370624
38Amniotic constriction ring (HP:0009775)2.95370624
39Acanthosis nigricans (HP:0000956)2.85763890
40Abnormality of the gastric mucosa (HP:0004295)2.84259961
41Hypoplasia of dental enamel (HP:0006297)2.79241429
42Fatigable weakness (HP:0003473)2.78704643
43Abnormality of the neuromuscular junction (HP:0003398)2.78704643
44Down-sloping shoulders (HP:0200021)2.73219387
45* Palmoplantar keratoderma (HP:0000982)2.63830663
46Hypohidrosis (HP:0000966)2.63279555
47Distal lower limb muscle weakness (HP:0009053)2.61408985
48Corneal erosion (HP:0200020)2.56488857
49Curly hair (HP:0002212)2.55134556
50Ectropion (HP:0000656)2.46705899
51Pterygium (HP:0001059)2.40734839
52Abnormality of hair growth rate (HP:0011363)2.39623540
53Slow-growing hair (HP:0002217)2.39623540
54Pruritus (HP:0000989)2.37625178
55Skin pits (HP:0100276)2.36142313
56Conjunctival hamartoma (HP:0100780)2.34410117
57Oral leukoplakia (HP:0002745)2.32038123
58Blepharitis (HP:0000498)2.31435034
59Premature rupture of membranes (HP:0001788)2.31059692
60Congenital, generalized hypertrichosis (HP:0004540)2.27373611
61Increased connective tissue (HP:0009025)2.25067301
62Ventricular fibrillation (HP:0001663)2.21393960
63Esophageal atresia (HP:0002032)2.20933420
64* Anonychia (HP:0001798)2.14986088
65Upper limb muscle weakness (HP:0003484)2.09209416
66Labial hypoplasia (HP:0000066)2.05512038
67Multifactorial inheritance (HP:0001426)2.03305570
68Absent hair (HP:0002298)2.02458879
69* Sparse scalp hair (HP:0002209)1.96893954
70* Hyperhidrosis (HP:0000975)1.96305819
71Amelogenesis imperfecta (HP:0000705)1.94813670
72Dehydration (HP:0001944)1.94072889
73Breast hypoplasia (HP:0003187)1.93833825
74Oligodontia (HP:0000677)1.93650958
75Gangrene (HP:0100758)1.93280767
76Cheilitis (HP:0100825)1.92756867
77Hypoplastic female external genitalia (HP:0012815)1.91604652
78Distal lower limb amyotrophy (HP:0008944)1.90878540
79Abnormality of the parietal bone (HP:0002696)1.89666903
80Neonatal death (HP:0003811)1.88397818
81Squamous cell carcinoma (HP:0002860)1.87248704
82Nasolacrimal duct obstruction (HP:0000579)1.86497957
83Septate vagina (HP:0001153)1.86104507
84Xerostomia (HP:0000217)1.84605941
85Split foot (HP:0001839)1.83901719
86Popliteal pterygium (HP:0009756)1.83164772
87* Laryngomalacia (HP:0001601)1.82271369
88Hypoplasia of the uterus (HP:0000013)1.80048266
89Achilles tendon contracture (HP:0001771)1.79911915
90Absent eyelashes (HP:0000561)1.76884654
91Hypergammaglobulinemia (HP:0010702)1.74638612
92Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.74152399
93Neonatal onset (HP:0003623)1.73959044
94Aplasia involving bones of the extremities (HP:0009825)1.73826458
95Aplasia involving bones of the upper limbs (HP:0009823)1.73826458
96Aplasia of the phalanges of the hand (HP:0009802)1.73826458
97Skin ulcer (HP:0200042)1.72921628
98Trismus (HP:0000211)1.71447291
99Type 1 muscle fiber predominance (HP:0003803)1.71388563
100* Abnormality of the fingernails (HP:0001231)1.69722776
101* Corneal dystrophy (HP:0001131)1.67632370
102Abnormality of the Achilles tendon (HP:0005109)1.65695180
103Concave nail (HP:0001598)1.65120582
104Abnormality of the salivary glands (HP:0010286)1.62806322
105* Carious teeth (HP:0000670)1.61854660
106Abnormality of oral frenula (HP:0000190)1.61109611
107Hypodontia (HP:0000668)1.59833078
108Neurofibrillary tangles (HP:0002185)1.59364670
109Abnormality of permanent molar morphology (HP:0011071)1.58350413
110Abnormality of the dental root (HP:0006486)1.58350413
111Taurodontia (HP:0000679)1.58350413
112Ankyloglossia (HP:0010296)1.57819459
113Autoamputation (HP:0001218)1.56666420
114Hyporeflexia of lower limbs (HP:0002600)1.55601923
115Abnormality of the distal phalanges of the toes (HP:0010182)1.53659294
116Broad face (HP:0000283)1.53063006
117Scapular winging (HP:0003691)1.53037321
118Ureteral stenosis (HP:0000071)1.52839101
119Abnormality of secondary sexual hair (HP:0009888)1.51171678
120Abnormality of the axillary hair (HP:0100134)1.51171678
121Abnormal sex determination (HP:0012244)1.50694321
122Sex reversal (HP:0012245)1.50694321
123Abnormal hemoglobin (HP:0011902)1.49738414
124Axonal loss (HP:0003447)1.49482261
125Peritonitis (HP:0002586)1.49267504
126Duplicated collecting system (HP:0000081)1.48650803
127Obstructive sleep apnea (HP:0002870)1.48474109
128Eczematoid dermatitis (HP:0000976)1.48196210
129Short nail (HP:0001799)1.47117665
130Osteolytic defects of the hand bones (HP:0009699)1.46561934
131Osteolytic defects of the phalanges of the hand (HP:0009771)1.46561934
132Pustule (HP:0200039)1.46298704
133Abnormality of molar (HP:0011077)1.45050859
134Abnormality of molar morphology (HP:0011070)1.45050859
135Abnormality of the lacrimal duct (HP:0011481)1.44469497
136Ureteral duplication (HP:0000073)1.43536611

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.39530048
2MST44.87226452
3MAPKAPK34.19651921
4ARAF3.28139071
5FER3.18454609
6NTRK13.00783176
7LATS12.95956680
8MAP3K32.63895291
9STK242.56556059
10EPHA22.35123792
11EEF2K2.33694555
12RPS6KB22.33031698
13FRK2.27993245
14MST1R2.19348820
15FLT32.17626959
16TRPM72.09717041
17ERN12.06306676
18CDK32.03710574
19PIM21.82753845
20MAP3K21.75903735
21ERBB31.56518398
22MAP3K101.55094628
23PTK61.54184175
24LMTK21.53396109
25MAPK151.52386686
26RIPK11.51718617
27STK101.46828561
28EPHA31.45845655
29NME11.45007160
30LRRK21.41485224
31MAP3K61.40115972
32PAK41.39765991
33DYRK1B1.37417523
34FGFR41.36165556
35MAPKAPK51.32952800
36EPHB11.31142661
37MAP3K141.27602666
38NME21.26256250
39EPHA41.25524445
40TAOK11.20998712
41TRIB31.14516201
42SMG11.13455126
43KSR21.11739153
44TGFBR21.11661632
45GRK11.10853486
46TYK21.09916644
47MET1.09358445
48STK38L1.07483305
49PIK3CG1.07424617
50BRAF1.06710203
51PTK21.00117333
52PBK0.97967684
53MAPKAPK20.97510451
54PRPF4B0.95578397
55BCR0.94925305
56MOS0.94339247
57STK380.92790218
58MAP2K20.89811128
59CDK120.88372944
60MAP3K130.87357581
61NEK90.87061052
62MAP3K120.86299135
63RAF10.84236931
64TESK10.80561812
65MAP3K70.78428146
66MAP3K90.77387002
67MAP2K60.76601970
68TNK20.70469727
69DYRK30.70158214
70LATS20.67586694
71TTN0.66709983
72MAP3K10.66288105
73BMX0.65927098
74HIPK20.65879355
75CDK60.64297949
76STK30.63907799
77JAK30.63518017
78ROCK20.62217299
79PRKD20.61399552
80ERBB20.61356594
81IRAK30.60661992
82PRKCE0.60607836
83CHUK0.57653554
84DDR20.57176371
85TGFBR10.56668561
86PRKCI0.54988417
87ERBB40.53710436
88MTOR0.53700195
89BMPR1B0.53591892
90NUAK10.52743380
91MAP2K10.52409731
92ABL20.52385935
93CSF1R0.51793528
94LIMK10.50575757
95IKBKE0.49508793
96JAK10.49214787
97CDC42BPA0.48248173
98MAP3K80.48139038
99RPS6KA40.47886683
100PRKD10.47239358
101ILK0.45431818
102JAK20.44682060
103NEK60.43557199
104CSNK1D0.42958219
105NTRK20.41015396
106ROCK10.40172443
107PAK20.39905272
108TBK10.39512590
109BTK0.39120008
110PAK30.37811739
111PDGFRA0.37427155
112ICK0.37419280
113SIK10.37413363
114FGFR20.36501287
115FGFR30.35884024
116SIK30.35289327
117FGFR10.34464555
118CLK10.34153022
119MATK0.34058564
120KSR10.33864926
121RPS6KL10.33063956
122RPS6KC10.33063956
123RET0.32179770
124AURKA0.31949213
125NLK0.31944464
126* RPS6KA10.31290800
127IKBKB0.30983839
128SRC0.30540570
129MAP3K110.29938741
130PKN20.29658331
131ADRBK10.29330380
132MAPK30.28569986
133HCK0.28008734
134PDGFRB0.28003406
135ITK0.27881452
136GSK3A0.27873432
137RPS6KA20.27779698
138FGR0.27679293
139CDK70.27511007
140RPS6KB10.26823668
141NEK10.19242891
142RPS6KA60.18264082
143SGK2230.17259244
144SGK4940.17259244
145SGK30.16829490
146INSR0.16190615
147EIF2AK20.15940821
148PRKG20.15844217
149TSSK60.15824943
150PRKCD0.14815999

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.06175832
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.95578404
3Basal cell carcinoma_Homo sapiens_hsa052172.75746826
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.69192353
5Phenylalanine metabolism_Homo sapiens_hsa003602.51711200
6Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.35612714
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20374427
8ECM-receptor interaction_Homo sapiens_hsa045122.20189737
9Histidine metabolism_Homo sapiens_hsa003402.12839402
10Graft-versus-host disease_Homo sapiens_hsa053322.10416505
11Fatty acid elongation_Homo sapiens_hsa000622.04073256
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01384397
13Ether lipid metabolism_Homo sapiens_hsa005651.91536110
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.85663777
15Central carbon metabolism in cancer_Homo sapiens_hsa052301.85244285
16Hedgehog signaling pathway_Homo sapiens_hsa043401.83458384
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83449610
18Arachidonic acid metabolism_Homo sapiens_hsa005901.78867888
19Steroid biosynthesis_Homo sapiens_hsa001001.74640341
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69370921
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.58870547
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58155028
23Hippo signaling pathway_Homo sapiens_hsa043901.57826384
24Chemical carcinogenesis_Homo sapiens_hsa052041.54751966
25Sphingolipid metabolism_Homo sapiens_hsa006001.52147425
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46797793
27Axon guidance_Homo sapiens_hsa043601.44081711
28Chronic myeloid leukemia_Homo sapiens_hsa052201.43672087
29Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.41725441
30Antigen processing and presentation_Homo sapiens_hsa046121.40380478
31Melanogenesis_Homo sapiens_hsa049161.39241793
32Proteoglycans in cancer_Homo sapiens_hsa052051.38276753
33Prion diseases_Homo sapiens_hsa050201.34414647
34Tight junction_Homo sapiens_hsa045301.31830864
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27452540
36Dorso-ventral axis formation_Homo sapiens_hsa043201.23585654
37Ribosome_Homo sapiens_hsa030101.23028563
38Amoebiasis_Homo sapiens_hsa051461.20731401
39Asthma_Homo sapiens_hsa053101.17401528
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16182205
41Adherens junction_Homo sapiens_hsa045201.16149426
42Notch signaling pathway_Homo sapiens_hsa043301.14201495
43Galactose metabolism_Homo sapiens_hsa000521.13124030
44Tyrosine metabolism_Homo sapiens_hsa003501.12807724
45Shigellosis_Homo sapiens_hsa051311.10602072
46Leukocyte transendothelial migration_Homo sapiens_hsa046701.10457610
47Toxoplasmosis_Homo sapiens_hsa051451.09576013
48Fat digestion and absorption_Homo sapiens_hsa049751.09057726
49Inositol phosphate metabolism_Homo sapiens_hsa005621.08178475
50Renal cell carcinoma_Homo sapiens_hsa052111.08055325
51Bladder cancer_Homo sapiens_hsa052191.06274852
52Dilated cardiomyopathy_Homo sapiens_hsa054141.05611143
53Pertussis_Homo sapiens_hsa051331.05533395
54Pancreatic cancer_Homo sapiens_hsa052121.05352795
55Endometrial cancer_Homo sapiens_hsa052131.03550746
56Insulin signaling pathway_Homo sapiens_hsa049101.00265665
57TGF-beta signaling pathway_Homo sapiens_hsa043500.99290192
58Small cell lung cancer_Homo sapiens_hsa052220.98886488
59VEGF signaling pathway_Homo sapiens_hsa043700.98221165
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.96588476
61Salmonella infection_Homo sapiens_hsa051320.94703952
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93383037
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92510069
64Collecting duct acid secretion_Homo sapiens_hsa049660.87283181
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86934761
66Endocytosis_Homo sapiens_hsa041440.86649667
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86258593
68Acute myeloid leukemia_Homo sapiens_hsa052210.84767850
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83697574
70Focal adhesion_Homo sapiens_hsa045100.82282033
71TNF signaling pathway_Homo sapiens_hsa046680.82125489
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82079871
73Wnt signaling pathway_Homo sapiens_hsa043100.81904412
74Protein digestion and absorption_Homo sapiens_hsa049740.81338177
75Sulfur metabolism_Homo sapiens_hsa009200.80251920
76GnRH signaling pathway_Homo sapiens_hsa049120.78385586
77MicroRNAs in cancer_Homo sapiens_hsa052060.74552824
78Phototransduction_Homo sapiens_hsa047440.73989934
79Ras signaling pathway_Homo sapiens_hsa040140.73409855
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72507365
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.72482304
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.70377905
83Non-small cell lung cancer_Homo sapiens_hsa052230.69627328
84Pathways in cancer_Homo sapiens_hsa052000.69463317
85Estrogen signaling pathway_Homo sapiens_hsa049150.68992925
86Arginine biosynthesis_Homo sapiens_hsa002200.68662185
87AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67828792
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67570338
89Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67087774
90Hepatitis C_Homo sapiens_hsa051600.66744283
91Prolactin signaling pathway_Homo sapiens_hsa049170.66353896
92Fructose and mannose metabolism_Homo sapiens_hsa000510.64309335
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63980422
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61148503
95Rap1 signaling pathway_Homo sapiens_hsa040150.61123090
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60262565
97Apoptosis_Homo sapiens_hsa042100.60209260
98Gastric acid secretion_Homo sapiens_hsa049710.59920439
99p53 signaling pathway_Homo sapiens_hsa041150.59482018
100Circadian rhythm_Homo sapiens_hsa047100.58212482
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58112537
102Neurotrophin signaling pathway_Homo sapiens_hsa047220.57804401
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.57448809
104Renin secretion_Homo sapiens_hsa049240.56248620
105HTLV-I infection_Homo sapiens_hsa051660.55833882
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55611964
107beta-Alanine metabolism_Homo sapiens_hsa004100.55399434
108ABC transporters_Homo sapiens_hsa020100.54459935
109Long-term depression_Homo sapiens_hsa047300.53596051
110Thyroid cancer_Homo sapiens_hsa052160.53137619
111T cell receptor signaling pathway_Homo sapiens_hsa046600.52945725
112Osteoclast differentiation_Homo sapiens_hsa043800.52129565
113Retinol metabolism_Homo sapiens_hsa008300.50786824
114Glioma_Homo sapiens_hsa052140.49776705
115Platelet activation_Homo sapiens_hsa046110.49697259
116Ovarian steroidogenesis_Homo sapiens_hsa049130.48930773
117Olfactory transduction_Homo sapiens_hsa047400.48718845
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.48367298
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.48313067
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47776199
121Pancreatic secretion_Homo sapiens_hsa049720.47509183
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.46760960
123Hematopoietic cell lineage_Homo sapiens_hsa046400.46235306
124Choline metabolism in cancer_Homo sapiens_hsa052310.46096126
125Tuberculosis_Homo sapiens_hsa051520.45723433
126Viral carcinogenesis_Homo sapiens_hsa052030.44947167
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.44598651
128HIF-1 signaling pathway_Homo sapiens_hsa040660.44357153
129ErbB signaling pathway_Homo sapiens_hsa040120.44239712
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43464079
131Pentose phosphate pathway_Homo sapiens_hsa000300.43320313
132Rheumatoid arthritis_Homo sapiens_hsa053230.42512087
133Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42391878
134Amphetamine addiction_Homo sapiens_hsa050310.42170349
135N-Glycan biosynthesis_Homo sapiens_hsa005100.41922047
136African trypanosomiasis_Homo sapiens_hsa051430.41802548
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.41726105
138mTOR signaling pathway_Homo sapiens_hsa041500.40028938
139Oxytocin signaling pathway_Homo sapiens_hsa049210.39577474
140Glucagon signaling pathway_Homo sapiens_hsa049220.39477296
141Melanoma_Homo sapiens_hsa052180.39112001
142Prostate cancer_Homo sapiens_hsa052150.38660191
143Insulin resistance_Homo sapiens_hsa049310.36992196
144Malaria_Homo sapiens_hsa051440.36904481
145Caffeine metabolism_Homo sapiens_hsa002320.36646751
146Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33147681
147Glycerolipid metabolism_Homo sapiens_hsa005610.32793557
148Influenza A_Homo sapiens_hsa051640.32785690
149Gap junction_Homo sapiens_hsa045400.32650231
150Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32647529

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