ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	keratinocyte proliferation (GO:0043616)	5.61964490
2	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.60790279
3	keratinization (GO:0031424)	5.52264532
4	establishment of skin barrier (GO:0061436)	5.46876661
5	negative regulation of keratinocyte proliferation (GO:0010839)	5.45201602
6	synaptic vesicle docking involved in exocytosis (GO:0016081)	5.12118000
7	regulation of water loss via skin (GO:0033561)	5.03348373
8	glutamate secretion (GO:0014047)	4.88786026
9	cell-substrate junction assembly (GO:0007044)	4.85379520
10	intermediate filament organization (GO:0045109)	4.52648225
11	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.34035453
12	positive regulation of hair follicle development (GO:0051798)	4.27697278
13	positive regulation of hair cycle (GO:0042635)	4.27697278
14	white fat cell differentiation (GO:0050872)	4.19539578
15	hair cycle (GO:0042633)	3.79433251
16	molting cycle (GO:0042303)	3.79433251
17	homocysteine metabolic process (GO:0050667)	3.77727279
18	regulation of plasminogen activation (GO:0010755)	3.72695576
19	NIK/NF-kappaB signaling (GO:0038061)	3.72390163
20	synaptic vesicle exocytosis (GO:0016079)	3.70674275
21	regulation of hair follicle development (GO:0051797)	3.69142773
22	synaptic vesicle maturation (GO:0016188)	3.57483332
23	G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)	3.55602522
24	phosphatidylglycerol biosynthetic process (GO:0006655)	3.46846418
25	intermediate filament cytoskeleton organization (GO:0045104)	3.43781325
26	microtubule nucleation (GO:0007020)	3.43357621
27	innervation (GO:0060384)	3.40999023
28	positive regulation of epidermis development (GO:0045684)	3.40380452
29	regulation of keratinocyte proliferation (GO:0010837)	3.39627561
30	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.38276576
31	primary amino compound metabolic process (GO:1901160)	3.36627678
32	regulation of vitamin D biosynthetic process (GO:0060556)	3.33282774
33	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.33234999
34	intermediate filament-based process (GO:0045103)	3.33026845
35	cell migration involved in heart development (GO:0060973)	3.32937962
36	behavioral response to pain (GO:0048266)	3.29360311
37	negative regulation of acute inflammatory response (GO:0002674)	3.26947870
38	sodium ion export (GO:0071436)	3.24882750
39	cochlea development (GO:0090102)	3.24038167
40	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20380670
41	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20380670
42	regulation of hair cycle (GO:0042634)	3.19155504
43	folic acid-containing compound biosynthetic process (GO:0009396)	3.11916275
44	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.09128802
45	multicellular organismal water homeostasis (GO:0050891)	3.07947816
46	negative regulation of catenin import into nucleus (GO:0035414)	3.03594180
47	keratinocyte differentiation (GO:0030216)	3.02233263
48	epidermis development (GO:0008544)	3.01947481
49	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.95611023
50	neurotransmitter secretion (GO:0007269)	2.94022452
51	endothelial cell chemotaxis (GO:0035767)	2.93815643
52	cell communication involved in cardiac conduction (GO:0086065)	2.91155548
53	membrane tubulation (GO:0097320)	2.89507319
54	regulation of synaptic vesicle exocytosis (GO:2000300)	2.84390861
55	purine nucleotide salvage (GO:0032261)	2.80542762
56	cellular potassium ion homeostasis (GO:0030007)	2.79527196
57	neuronal ion channel clustering (GO:0045161)	2.75366852
58	regulation of transforming growth factor beta1 production (GO:0032908)	2.72795601
59	negative regulation of Ras GTPase activity (GO:0034261)	2.70827681
60	peptide cross-linking (GO:0018149)	2.67872909
61	chemosensory behavior (GO:0007635)	2.66662359
62	epithelial cell differentiation involved in prostate gland development (GO:0060742)	2.66100390
63	sulfur amino acid catabolic process (GO:0000098)	2.63652156
64	peptidyl-tyrosine autophosphorylation (GO:0038083)	2.61916929
65	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.60734174
66	signal complex assembly (GO:0007172)	2.59447565
67	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.58994735
68	negative regulation of erythrocyte differentiation (GO:0045647)	2.58986522
69	cell-substrate adherens junction assembly (GO:0007045)	2.58825558
70	focal adhesion assembly (GO:0048041)	2.58825558
71	protein localization to endosome (GO:0036010)	2.57976345
72	cysteine metabolic process (GO:0006534)	2.57465500
73	cerebellar Purkinje cell differentiation (GO:0021702)	2.57350388
74	regulation of neuronal synaptic plasticity (GO:0048168)	2.56609712
75	positive regulation of synapse maturation (GO:0090129)	2.55821298
76	regulation of necroptotic process (GO:0060544)	2.55507776
77	keratinocyte development (GO:0003334)	2.53203585
78	behavioral defense response (GO:0002209)	2.52971292
79	behavioral fear response (GO:0001662)	2.52971292
80	regulation of vitamin metabolic process (GO:0030656)	2.52020740
81	surfactant homeostasis (GO:0043129)	2.49214462
82	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.48383188
83	postsynaptic membrane organization (GO:0001941)	2.47388034
84	regulation of gonadotropin secretion (GO:0032276)	2.45784651
85	dendritic spine organization (GO:0097061)	2.44251542
86	vesicle targeting (GO:0006903)	2.43763354
87	long-term memory (GO:0007616)	2.43581675
88	response to muramyl dipeptide (GO:0032495)	2.42572432
89	negative regulation of interleukin-2 production (GO:0032703)	2.42460665
90	water homeostasis (GO:0030104)	2.42128722
91	regulation of heart rate by cardiac conduction (GO:0086091)	2.40097529
92	alternative mRNA splicing, via spliceosome (GO:0000380)	2.38760351
93	negative regulation of alcohol biosynthetic process (GO:1902931)	2.38346544
94	cerebellar granule cell differentiation (GO:0021707)	2.37835269
95	amino acid import (GO:0043090)	2.37205838
96	atrioventricular valve morphogenesis (GO:0003181)	2.36678247
97	filopodium assembly (GO:0046847)	2.36180971
98	epidermal cell differentiation (GO:0009913)	2.35528841
99	desmosome organization (GO:0002934)	11.2710331
100	hemidesmosome assembly (GO:0031581)	11.2524431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	3.66424258
2	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.70576646
3	LXR_22292898_ChIP-Seq_THP-1_Human	2.50777388
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.48731430
5	P63_26484246_Chip-Seq_KERATINOCYTES_Human	2.35077621
6	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.32861481
7	ZNF263_19887448_ChIP-Seq_K562_Human	2.15125988
8	ERG_21242973_ChIP-ChIP_JURKAT_Human	2.09438844
9	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	2.06455471
10	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.04063171
11	DROSHA_22980978_ChIP-Seq_HELA_Human	2.02430182
12	TP63_17297297_ChIP-ChIP_HaCaT_Human	11.6603842
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.91714312
14	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.90374853
15	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.88367725
16	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.85201191
17	TP63_22573176_ChIP-Seq_HFKS_Human	1.73579775
18	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.70097166
19	KDM2B_26808549_Chip-Seq_K562_Human	1.67441924
20	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.64374622
21	SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.62903821
22	SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.62903821
23	P68_20966046_ChIP-Seq_HELA_Human	1.61637273
24	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.54515294
25	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.54318468
26	CTCF_27219007_Chip-Seq_Bcells_Human	1.51807696
27	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.50379361
28	RACK7_27058665_Chip-Seq_MCF-7_Human	1.48163887
29	SMC4_20622854_ChIP-Seq_HELA_Human	1.48141725
30	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.45597061
31	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.44537660
32	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.44401531
33	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.44079498
34	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.43596822
35	TET1_21490601_ChIP-Seq_MESCs_Mouse	1.41189529
36	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.39929369
37	TCF7_22412390_ChIP-Seq_EML_Mouse	1.36369242
38	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.36045424
39	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.35633765
40	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.35508690
41	KDM2B_26808549_Chip-Seq_DND41_Human	1.33695901
42	VDR_21846776_ChIP-Seq_THP-1_Human	1.33051116
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.32638564
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.32638564
45	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.30108362
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.29984841
47	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29303074
48	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.27049908
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.26976562
50	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.24508390
51	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.24316268
52	CREB1_26743006_Chip-Seq_LNCaP_Human	1.21362929
53	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.19140665
54	EGR1_19032775_ChIP-ChIP_M12_Human	1.18965072
55	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.18551814
56	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17167645
57	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.15878777
58	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15472369
59	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12159238
60	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.10114085
61	KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human	1.09747043
62	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.09710757
63	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.09590540
64	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.08323246
65	ZFP281_18757296_ChIP-ChIP_E14_Mouse	1.07953455
66	REST_21632747_ChIP-Seq_MESCs_Mouse	1.07942228
67	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.06916056
68	UBF1/2_26484160_Chip-Seq_HMECs_Human	1.05087607
69	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.03708487
70	KLF5_25053715_ChIP-Seq_YYC3_Human	1.03311459
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.02618006
72	ATF3_27146783_Chip-Seq_COLON_Human	1.02225745
73	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.02151437
74	KDM2B_26808549_Chip-Seq_JURKAT_Human	1.01250572
75	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99145534
76	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.97552041
77	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97379683
78	BCOR_27268052_Chip-Seq_Bcells_Human	0.96270125
79	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.95862229
80	VDR_24763502_ChIP-Seq_THP-1_Human	0.95518723
81	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.93319690
82	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.93083265
83	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.91862165
84	SA1_27219007_Chip-Seq_Bcells_Human	0.91577917
85	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.91160269
86	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.90373084
87	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.88958283
88	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.88396865
89	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.88367807
90	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.88062537
91	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.87580728
92	EZH2_22144423_ChIP-Seq_EOC_Human	0.86549375
93	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.86485372
94	KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86329966
95	WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.86247249
96	TP53_22127205_ChIP-Seq_IMR90_Human	0.84972164
97	TP53_23651856_ChIP-Seq_MEFs_Mouse	0.83661109
98	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.83149010
99	JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse	0.82378469
100	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.82276540

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000579_abnormal_nail_morphology	8.00690574
2	MP0003705_abnormal_hypodermis_morpholog	4.03553723
3	MP0004381_abnormal_hair_follicle	3.77452487
4	MP0002796_impaired_skin_barrier	3.56851881
5	MP0010234_abnormal_vibrissa_follicle	3.32846415
6	MP0004859_abnormal_synaptic_plasticity	3.15329640
7	MP0000566_synostosis	2.90713967
8	MP0000013_abnormal_adipose_tissue	2.61872490
9	MP0003453_abnormal_keratinocyte_physiol	2.53388479
10	MP0000762_abnormal_tongue_morphology	2.36793672
11	MP0002060_abnormal_skin_morphology	2.30224317
12	MP0002736_abnormal_nociception_after	2.26995216
13	MP0001216_abnormal_epidermal_layer	2.26642953
14	MP0003183_abnormal_peptide_metabolism	2.26271475
15	MP0003880_abnormal_central_pattern	2.24535217
16	MP0004885_abnormal_endolymph	2.23686455
17	MP0000467_abnormal_esophagus_morphology	2.20476343
18	MP0001849_ear_inflammation	2.20066085
19	MP0002098_abnormal_vibrissa_morphology	2.18854285
20	MP0005409_darkened_coat_color	2.17494258
21	MP0010678_abnormal_skin_adnexa	2.11573872
22	MP0001968_abnormal_touch/_nociception	2.10543933
23	MP0000383_abnormal_hair_follicle	2.04550540
24	MP0005275_abnormal_skin_tensile	1.95398595
25	MP0010771_integument_phenotype	1.93145829
26	MP0005501_abnormal_skin_physiology	1.85821803
27	MP0003635_abnormal_synaptic_transmissio	1.84336023
28	MP0004947_skin_inflammation	1.84092479
29	MP0002234_abnormal_pharynx_morphology	1.80349698
30	MP0002396_abnormal_hematopoietic_system	1.79261388
31	MP0005360_urolithiasis	1.72710882
32	MP0008569_lethality_at_weaning	1.70121376
33	MP0001851_eye_inflammation	1.59224911
34	MP0004270_analgesia	1.58535364
35	MP0005423_abnormal_somatic_nervous	1.57368267
36	MP0003566_abnormal_cell_adhesion	1.56780781
37	MP0003941_abnormal_skin_development	1.53117201
38	MP0005646_abnormal_pituitary_gland	1.52588587
39	MP0002063_abnormal_learning/memory/cond	1.49744059
40	MP0002064_seizures	1.47082621
41	MP0000003_abnormal_adipose_tissue	1.44950686
42	MP0000377_abnormal_hair_follicle	1.43120845
43	MP0001501_abnormal_sleep_pattern	1.38493468
44	MP0005075_abnormal_melanosome_morpholog	1.37188439
45	MP0003045_fibrosis	1.35081180
46	MP0004185_abnormal_adipocyte_glucose	1.32862102
47	MP0001661_extended_life_span	1.31482719
48	MP0003329_amyloid_beta_deposits	1.29507747
49	MP0008874_decreased_physiological_sensi	1.29394543
50	MP0002572_abnormal_emotion/affect_behav	1.29149213
51	MP0003172_abnormal_lysosome_physiology	1.25739199
52	MP0008260_abnormal_autophagy	1.22278960
53	MP0009745_abnormal_behavioral_response	1.21079426
54	MP0002272_abnormal_nervous_system	1.19304412
55	MP0001502_abnormal_circadian_rhythm	1.17638566
56	MP0001486_abnormal_startle_reflex	1.16186326
57	MP0004264_abnormal_extraembryonic_tissu	1.14518446
58	MP0002734_abnormal_mechanical_nocicepti	1.13924699
59	MP0000678_abnormal_parathyroid_gland	1.12390159
60	MP0000920_abnormal_myelination	1.11919257
61	MP0009931_abnormal_skin_appearance	1.09154682
62	MP0000367_abnormal_coat/_hair	1.06843247
63	MP0003191_abnormal_cellular_cholesterol	1.01740598
64	MP0003075_altered_response_to	1.00135818
65	MP0000427_abnormal_hair_cycle	0.96796085
66	MP0002735_abnormal_chemical_nociception	0.93596629
67	MP0005023_abnormal_wound_healing	0.93117637
68	MP0004043_abnormal_pH_regulation	0.86098915
69	MP0005670_abnormal_white_adipose	0.84277362
70	MP0004130_abnormal_muscle_cell	0.83097828
71	MP0008995_early_reproductive_senescence	0.77185986
72	MP0001440_abnormal_grooming_behavior	0.75797006
73	MP0002733_abnormal_thermal_nociception	0.72131795
74	MP0005076_abnormal_cell_differentiation	0.71764856
75	MP0003763_abnormal_thymus_physiology	0.71497068
76	MP0004019_abnormal_vitamin_homeostasis	0.69919921
77	MP0005375_adipose_tissue_phenotype	0.69682292
78	MP0000647_abnormal_sebaceous_gland	0.67123850
79	MP0000604_amyloidosis	0.65841031
80	MP0003436_decreased_susceptibility_to	0.65332654
81	MP0003690_abnormal_glial_cell	0.63283600
82	MP0005166_decreased_susceptibility_to	0.61738431
83	MP0001191_abnormal_skin_condition	0.61028264
84	MP0001765_abnormal_ion_homeostasis	0.59266459
85	MP0009046_muscle_twitch	0.56729535
86	MP0003638_abnormal_response/metabolism_	0.56562161
87	MP0001340_abnormal_eyelid_morphology	0.56436612
88	MP0005000_abnormal_immune_tolerance	0.55876956
89	MP0000627_abnormal_mammary_gland	0.54749444
90	MP0001970_abnormal_pain_threshold	0.54059860
91	MP0008872_abnormal_physiological_respon	0.53963434
92	MP0009053_abnormal_anal_canal	0.52251467
93	MP0002095_abnormal_skin_pigmentation	0.50073342
94	MP0004742_abnormal_vestibular_system	0.50066926
95	MP0003633_abnormal_nervous_system	0.49548448
96	MP0002229_neurodegeneration	0.48665176
97	MP0004811_abnormal_neuron_physiology	0.47983710
98	MP0002089_abnormal_postnatal_growth/wei	0.47919991
99	MP0003879_abnormal_hair_cell	0.47210264
100	MP0001177_atelectasis	0.46467638

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of nail color (HP:0100643)	8.38717622
2	Milia (HP:0001056)	7.01197227
3	Plantar hyperkeratosis (HP:0007556)	6.91597254
4	Thick nail (HP:0001805)	6.18434397
5	Onycholysis (HP:0001806)	6.06883294
6	Fragile nails (HP:0001808)	5.98545748
7	Palmoplantar hyperkeratosis (HP:0000972)	5.78654425
8	Palmar hyperkeratosis (HP:0010765)	5.36616176
9	Alopecia of scalp (HP:0002293)	5.02998690
10	Nail dystrophy (HP:0008404)	4.76379845
11	Atrophic scars (HP:0001075)	4.58876456
12	Ridged nail (HP:0001807)	3.92491230
13	Abnormal blistering of the skin (HP:0008066)	3.85569641
14	Action tremor (HP:0002345)	3.65398000
15	Pili torti (HP:0003777)	3.62344886
16	Oral leukoplakia (HP:0002745)	3.51718362
17	Epidermoid cyst (HP:0200040)	3.44840054
18	Right ventricular cardiomyopathy (HP:0011663)	3.42066628
19	Hypotrichosis (HP:0001006)	3.28522112
20	Obstructive sleep apnea (HP:0002870)	3.16698237
21	Increased IgE level (HP:0003212)	3.16192314
22	Sparse scalp hair (HP:0002209)	3.12265550
23	Lip pit (HP:0100267)	3.10246348
24	Abnormal hair laboratory examination (HP:0003328)	3.01898589
25	Broad face (HP:0000283)	2.96790238
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.96757653
27	Abnormality of alanine metabolism (HP:0010916)	2.96757653
28	Hyperalaninemia (HP:0003348)	2.96757653
29	Myokymia (HP:0002411)	2.88647704
30	Hypoplasia of dental enamel (HP:0006297)	2.83846343
31	Natal tooth (HP:0000695)	2.74548826
32	Abnormality of binocular vision (HP:0011514)	2.71646275
33	Diplopia (HP:0000651)	2.71646275
34	Fatigable weakness (HP:0003473)	2.69014686
35	Abnormality of the neuromuscular junction (HP:0003398)	2.69014686
36	Neurofibrillary tangles (HP:0002185)	2.65302250
37	Abnormality of the salivary glands (HP:0010286)	2.64037867
38	Atonic seizures (HP:0010819)	2.61423575
39	Woolly hair (HP:0002224)	2.60422025
40	Aplasia cutis congenita (HP:0001057)	2.55042035
41	Supranuclear gaze palsy (HP:0000605)	2.50493951
42	Pustule (HP:0200039)	2.50033128
43	White forelock (HP:0002211)	2.49941381
44	Abnormality of the axillary hair (HP:0100134)	2.49626668
45	Abnormality of secondary sexual hair (HP:0009888)	2.49626668
46	Corneal erosion (HP:0200020)	2.45685248
47	Pterygium (HP:0001059)	2.44127889
48	Erythema (HP:0010783)	2.43895994
49	Polygenic inheritance (HP:0010982)	2.40257479
50	Sparse eyelashes (HP:0000653)	2.38850203
51	Advanced eruption of teeth (HP:0006288)	2.36342880
52	Oligodontia (HP:0000677)	2.36235904
53	Parakeratosis (HP:0001036)	2.28291445
54	Constricted visual fields (HP:0001133)	2.27626394
55	Palmoplantar keratoderma (HP:0000982)	2.21430198
56	Duplicated collecting system (HP:0000081)	2.21338205
57	Dry hair (HP:0011359)	2.21047881
58	Congenital ichthyosiform erythroderma (HP:0007431)	2.19351539
59	Heterochromia iridis (HP:0001100)	2.18218213
60	Hypoplastic labia majora (HP:0000059)	2.15743232
61	Spontaneous hematomas (HP:0007420)	2.15130881
62	Multifactorial inheritance (HP:0001426)	2.10611964
63	Anonychia (HP:0001798)	2.10016636
64	Ankyloglossia (HP:0010296)	2.07986539
65	Hyperhidrosis (HP:0000975)	2.07891011
66	Laryngomalacia (HP:0001601)	2.07613380
67	Cheilitis (HP:0100825)	2.06691040
68	Fragile skin (HP:0001030)	2.06564676
69	Cerebral inclusion bodies (HP:0100314)	2.05882997
70	Popliteal pterygium (HP:0009756)	2.05329806
71	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.03361880
72	Patchy hypopigmentation of hair (HP:0011365)	2.02100362
73	Intention tremor (HP:0002080)	1.99352135
74	Abnormality of the renal collecting system (HP:0004742)	1.99245032
75	Spinal canal stenosis (HP:0003416)	1.97455837
76	Abnormality of the labia majora (HP:0012881)	1.97448325
77	Biconcave vertebral bodies (HP:0004586)	1.97154765
78	Focal motor seizures (HP:0011153)	1.96873110
79	Esophageal varix (HP:0002040)	1.96448300
80	Selective tooth agenesis (HP:0001592)	1.95915927
81	Focal seizures (HP:0007359)	1.95577370
82	Carious teeth (HP:0000670)	1.94894720
83	Ankle clonus (HP:0011448)	1.93747865
84	Nonprogressive disorder (HP:0003680)	1.92084118
85	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	1.89582229
86	Erythroderma (HP:0001019)	1.85885974
87	Visual hallucinations (HP:0002367)	1.85189738
88	Acanthosis nigricans (HP:0000956)	1.80846416
89	Congenital sensorineural hearing impairment (HP:0008527)	1.80671156
90	Abnormality of placental membranes (HP:0011409)	1.79324610
91	Amniotic constriction ring (HP:0009775)	1.79324610
92	Febrile seizures (HP:0002373)	1.78982346
93	Corneal dystrophy (HP:0001131)	1.74713303
94	Brittle hair (HP:0002299)	1.74488657
95	Hypodontia (HP:0000668)	1.74064003
96	Hypergammaglobulinemia (HP:0010702)	1.72895545
97	Impaired smooth pursuit (HP:0007772)	1.72307689
98	Neuronal loss in central nervous system (HP:0002529)	1.70518517
99	Skin ulcer (HP:0200042)	1.70098244
100	Ectropion (HP:0000656)	1.68257343

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA4	3.71775754
2	MAP3K3	3.05433601
3	EPHA2	2.75867621
4	MST1R	2.59567943
5	RIPK4	2.51411500
6	DAPK2	2.47149426
7	MAPK15	2.42106095
8	MAP2K3	2.32584629
9	MAP3K11	2.12002112
10	SIK1	2.11292183
11	ARAF	2.02795829
12	PRPF4B	1.99744618
13	PIM2	1.94886781
14	NTRK3	1.91329827
15	RIPK1	1.87559519
16	MAP3K6	1.83800368
17	NTRK1	1.81838918
18	UHMK1	1.81499920
19	MAP3K9	1.80782597
20	FGR	1.76268581
21	GRK5	1.61419980
22	NTRK2	1.59308008
23	SGK223	1.58365189
24	SGK494	1.58365189
25	JAK3	1.57134897
26	STK38	1.51311932
27	PAK6	1.50792439
28	NEK6	1.42604255
29	PRKD3	1.37501325
30	EPHB2	1.37423165
31	MAP3K2	1.33210357
32	MET	1.26374116
33	LMTK2	1.20231516
34	CAMKK1	1.19939799
35	MARK2	1.16262739
36	DAPK1	1.14794767
37	FES	1.12249615
38	CDK9	1.10089875
39	CAMK1	1.08919582
40	TRIB3	1.03904803
41	TNK2	1.02552643
42	LATS2	1.02045999
43	BLK	1.01886943
44	SGK3	0.98966881
45	MAP4K1	0.97848048
46	MAP3K13	0.97734469
47	PTK6	0.96024803
48	SGK2	0.94153887
49	BMPR2	0.91026840
50	CAMK2B	0.89966578
51	PRKCH	0.88838889
52	TGFBR1	0.80327583
53	MAP2K6	0.79666816
54	MAPK12	0.76975346
55	STK24	0.75456221
56	PRKD2	0.72441841
57	CDK5	0.72317017
58	PTK2	0.70064206
59	MAP3K1	0.69096550
60	MAP3K7	0.68732265
61	MINK1	0.67267445
62	SMG1	0.66886747
63	CSF1R	0.66793172
64	ZAP70	0.66757201
65	CAMK2G	0.65765564
66	RET	0.64947915
67	RPS6KB1	0.64181574
68	TESK1	0.63493516
69	HIPK2	0.63464190
70	TRPM7	0.63103438
71	KDR	0.62362326
72	CDK12	0.62085393
73	SGK1	0.61592498
74	IKBKB	0.60056790
75	ITK	0.58467634
76	DAPK3	0.53730232
77	FLT3	0.53508602
78	JAK1	0.52883872
79	BMX	0.52052444
80	ADRBK1	0.50197391
81	PDPK1	0.49763365
82	PDK1	0.49753954
83	MTOR	0.48441083
84	CAMK2A	0.48407994
85	GSK3A	0.47508929
86	FYN	0.47334559
87	RPS6KB2	0.47018338
88	EPHB1	0.46464847
89	SYK	0.46260277
90	RPS6KA1	0.46259986
91	ERN1	0.45773087
92	JAK2	0.44468115
93	MAPK4	0.42117200
94	SIK2	0.42093875
95	MAP2K1	0.41973619
96	PRKG2	0.41784790
97	MAPK7	0.40698899
98	MAPK8	0.39496530
99	RPS6KC1	0.35663703
100	RPS6KL1	0.35663703

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.37970882
2	Synaptic vesicle cycle_Homo sapiens_hsa04721	3.12769998
3	GABAergic synapse_Homo sapiens_hsa04727	2.65450179
4	Morphine addiction_Homo sapiens_hsa05032	2.57580179
5	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.57311584
6	Glutamatergic synapse_Homo sapiens_hsa04724	2.16684641
7	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.08121759
8	Circadian entrainment_Homo sapiens_hsa04713	2.07200373
9	Collecting duct acid secretion_Homo sapiens_hsa04966	1.92034166
10	Long-term potentiation_Homo sapiens_hsa04720	1.91149672
11	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.73818377
12	GnRH signaling pathway_Homo sapiens_hsa04912	1.67218363
13	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.66304977
14	Dopaminergic synapse_Homo sapiens_hsa04728	1.65386474
15	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	1.64661089
16	Serotonergic synapse_Homo sapiens_hsa04726	1.46998020
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.45723445
18	Amphetamine addiction_Homo sapiens_hsa05031	1.43710161
19	Cholinergic synapse_Homo sapiens_hsa04725	1.37105783
20	Other glycan degradation_Homo sapiens_hsa00511	1.36171933
21	Gastric acid secretion_Homo sapiens_hsa04971	1.35837176
22	Renin secretion_Homo sapiens_hsa04924	1.31851715
23	Salivary secretion_Homo sapiens_hsa04970	1.29912204
24	ErbB signaling pathway_Homo sapiens_hsa04012	1.21891285
25	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.21420204
26	ECM-receptor interaction_Homo sapiens_hsa04512	1.21047247
27	VEGF signaling pathway_Homo sapiens_hsa04370	1.16610945
28	Long-term depression_Homo sapiens_hsa04730	1.14229530
29	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.13857453
30	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	1.13005448
31	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.09511756
32	Calcium signaling pathway_Homo sapiens_hsa04020	1.09365833
33	Insulin secretion_Homo sapiens_hsa04911	1.08098979
34	Glioma_Homo sapiens_hsa05214	1.03876745
35	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.01893961
36	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.98896106
37	Amoebiasis_Homo sapiens_hsa05146	0.97014051
38	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.93153426
39	Taste transduction_Homo sapiens_hsa04742	0.91944662
40	Prion diseases_Homo sapiens_hsa05020	0.91631880
41	Regulation of autophagy_Homo sapiens_hsa04140	0.90065420
42	Olfactory transduction_Homo sapiens_hsa04740	0.89749993
43	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.89733207
44	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.89730163
45	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.87833284
46	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87203704
47	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.87057997
48	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.83191097
49	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.83047899
50	Pancreatic secretion_Homo sapiens_hsa04972	0.82437314
51	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.82257686
52	Estrogen signaling pathway_Homo sapiens_hsa04915	0.81419412
53	Vibrio cholerae infection_Homo sapiens_hsa05110	0.78186906
54	Ras signaling pathway_Homo sapiens_hsa04014	0.76171810
55	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.75253793
56	Choline metabolism in cancer_Homo sapiens_hsa05231	0.75017556
57	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75008153
58	Phototransduction_Homo sapiens_hsa04744	0.74337515
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73566690
60	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.73411350
61	Histidine metabolism_Homo sapiens_hsa00340	0.73148882
62	Sphingolipid metabolism_Homo sapiens_hsa00600	0.67593214
63	cAMP signaling pathway_Homo sapiens_hsa04024	0.67182422
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.67059541
65	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.65278596
66	Endocytosis_Homo sapiens_hsa04144	0.64904107
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.64679718
68	MAPK signaling pathway_Homo sapiens_hsa04010	0.63049033
69	Small cell lung cancer_Homo sapiens_hsa05222	0.62563939
70	Axon guidance_Homo sapiens_hsa04360	0.62211767
71	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.62122830
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.61173774
73	Toxoplasmosis_Homo sapiens_hsa05145	0.59854459
74	Galactose metabolism_Homo sapiens_hsa00052	0.59813151
75	Cocaine addiction_Homo sapiens_hsa05030	0.59265357
76	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.58676133
77	Melanogenesis_Homo sapiens_hsa04916	0.58098572
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57646612
79	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.57399821
80	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.56924433
81	Non-small cell lung cancer_Homo sapiens_hsa05223	0.56805642
82	ABC transporters_Homo sapiens_hsa02010	0.56407109
83	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.55422406
84	Focal adhesion_Homo sapiens_hsa04510	0.55207211
85	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.53058541
86	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.51632940
87	Thyroid cancer_Homo sapiens_hsa05216	0.51547574
88	Alcoholism_Homo sapiens_hsa05034	0.50496477
89	Notch signaling pathway_Homo sapiens_hsa04330	0.50239458
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.46680473
91	Rap1 signaling pathway_Homo sapiens_hsa04015	0.46526857
92	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.46453540
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44884385
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43645330
95	Sulfur relay system_Homo sapiens_hsa04122	0.43335395
96	TNF signaling pathway_Homo sapiens_hsa04668	0.43017527
97	Shigellosis_Homo sapiens_hsa05131	0.41853744
98	Osteoclast differentiation_Homo sapiens_hsa04380	0.41386004
99	Chemokine signaling pathway_Homo sapiens_hsa04062	0.39952386
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.39803018

KRT17P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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