ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to muscle activity (GO:0014850)	9.22343906
2	muscle filament sliding (GO:0030049)	9.03226368
3	actin-myosin filament sliding (GO:0033275)	9.03226368
4	actin-mediated cell contraction (GO:0070252)	7.68297480
5	regulation of skeletal muscle contraction (GO:0014819)	7.17283115
6	myofibril assembly (GO:0030239)	6.62391554
7	skeletal muscle contraction (GO:0003009)	6.55700424
8	sarcoplasmic reticulum calcium ion transport (GO:0070296)	6.09465252
9	muscle cell cellular homeostasis (GO:0046716)	6.07440123
10	piRNA metabolic process (GO:0034587)	5.62828328
11	regulation of relaxation of muscle (GO:1901077)	5.61777802
12	actin filament-based movement (GO:0030048)	5.56881163
13	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.54548566
14	AMP metabolic process (GO:0046033)	5.46923566
15	positive regulation of catecholamine secretion (GO:0033605)	5.46276374
16	ADP metabolic process (GO:0046031)	5.32849012
17	sarcomere organization (GO:0045214)	5.32246592
18	regulation of oxidative stress-induced neuron death (GO:1903203)	5.02644725
19	glycogen catabolic process (GO:0005980)	5.01670772
20	male meiosis (GO:0007140)	4.97790597
21	skeletal muscle fiber development (GO:0048741)	4.89215635
22	myotube cell development (GO:0014904)	4.81216615
23	coenzyme catabolic process (GO:0009109)	4.80249277
24	glucan catabolic process (GO:0009251)	4.72062866
25	regulation of oxidative phosphorylation (GO:0002082)	4.71420063
26	regulation of meiosis I (GO:0060631)	4.67510273
27	striated muscle contraction (GO:0006941)	4.64217424
28	cellular response to zinc ion (GO:0071294)	4.59163210
29	synapsis (GO:0007129)	4.52819078
30	glycogen metabolic process (GO:0005977)	4.48640509
31	cellular glucan metabolic process (GO:0006073)	4.40148510
32	glucan metabolic process (GO:0044042)	4.40148510
33	cytolysis (GO:0019835)	4.37320920
34	cellular polysaccharide catabolic process (GO:0044247)	4.36218227
35	cellular response to cadmium ion (GO:0071276)	4.33140046
36	response to mercury ion (GO:0046689)	4.22882743
37	creatine metabolic process (GO:0006600)	4.22623213
38	plasma membrane repair (GO:0001778)	4.17853077
39	muscle contraction (GO:0006936)	4.15027250
40	chromosome organization involved in meiosis (GO:0070192)	4.13922241
41	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	4.12042318
42	synaptonemal complex assembly (GO:0007130)	4.11726469
43	fructose metabolic process (GO:0006000)	4.08211180
44	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	4.02599581
45	synaptonemal complex organization (GO:0070193)	4.00280269
46	glucan biosynthetic process (GO:0009250)	3.97533850
47	glycogen biosynthetic process (GO:0005978)	3.97533850
48	polysaccharide catabolic process (GO:0000272)	3.96261199
49	DNA methylation involved in gamete generation (GO:0043046)	3.93645475
50	muscle cell fate commitment (GO:0042693)	3.89183475
51	muscle system process (GO:0003012)	3.86582147
52	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.82182271
53	nucleoside diphosphate biosynthetic process (GO:0009133)	3.80304440
54	male meiosis I (GO:0007141)	3.80211429
55	response to activity (GO:0014823)	3.76656047
56	cardiac muscle hypertrophy (GO:0003300)	3.73028222
57	muscle fiber development (GO:0048747)	3.70758507
58	motile cilium assembly (GO:0044458)	3.64847123
59	actomyosin structure organization (GO:0031032)	3.60430671
60	regulation of myoblast differentiation (GO:0045661)	3.59313199
61	meiotic nuclear division (GO:0007126)	3.57755971
62	striated muscle hypertrophy (GO:0014897)	3.53426378
63	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	3.52326402
64	glyoxylate metabolic process (GO:0046487)	3.52089523
65	cardiac myofibril assembly (GO:0055003)	3.51587677
66	acrosome reaction (GO:0007340)	3.50777529
67	exogenous drug catabolic process (GO:0042738)	3.48130778
68	skeletal muscle adaptation (GO:0043501)	3.40382209
69	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.36976400
70	purine nucleoside diphosphate metabolic process (GO:0009135)	3.35197184
71	purine ribonucleoside diphosphate metabolic process (GO:0009179)	3.35197184
72	quinone biosynthetic process (GO:1901663)	3.32055127
73	negative regulation of muscle contraction (GO:0045932)	3.27926519
74	relaxation of smooth muscle (GO:0044557)	3.27770741
75	omega-hydroxylase P450 pathway (GO:0097267)	3.25158555
76	negative regulation of response to reactive oxygen species (GO:1901032)	3.24767958
77	regulation of cellular respiration (GO:0043457)	3.24158053
78	muscle hypertrophy (GO:0014896)	3.22659462
79	ubiquinone biosynthetic process (GO:0006744)	3.21759592
80	skeletal muscle tissue development (GO:0007519)	3.21409475
81	response to inactivity (GO:0014854)	3.20700941
82	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.18146708
83	adult heart development (GO:0007512)	3.11275281
84	cofactor catabolic process (GO:0051187)	3.10420039
85	activation of protein kinase B activity (GO:0032148)	3.05839529
86	binding of sperm to zona pellucida (GO:0007339)	3.04878571
87	fatty acid transmembrane transport (GO:1902001)	3.02439678
88	TOR signaling (GO:0031929)	3.02158052
89	positive regulation of meiosis (GO:0045836)	3.02023304
90	positive regulation of meiotic cell cycle (GO:0051446)	2.99225827
91	meiosis I (GO:0007127)	2.98140184
92	carnitine shuttle (GO:0006853)	2.97599803
93	striated muscle adaptation (GO:0014888)	2.97152282
94	drug catabolic process (GO:0042737)	2.97079112
95	epoxygenase P450 pathway (GO:0019373)	2.96215568
96	relaxation of muscle (GO:0090075)	2.96199940
97	serine family amino acid catabolic process (GO:0009071)	2.96165936
98	cGMP-mediated signaling (GO:0019934)	2.96165550
99	IMP metabolic process (GO:0046040)	2.93140612
100	muscle organ development (GO:0007517)	2.90199215

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	7.89680390
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.85423340
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.84829355
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.82068071
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.44350324
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.03993189
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.94994334
8	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	3.15645441
9	EZH2_22144423_ChIP-Seq_EOC_Human	3.12740209
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.74544739
11	VDR_22108803_ChIP-Seq_LS180_Human	2.53453918
12	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.44695036
13	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	2.20174257
14	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.00902971
15	HTT_18923047_ChIP-ChIP_STHdh_Human	1.90392429
16	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.82583725
17	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.75315403
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71389566
19	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.68765432
20	CTCF_27219007_Chip-Seq_Bcells_Human	1.63504407
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.61729322
22	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.57140430
23	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.55911571
24	NANOG_20526341_ChIP-Seq_ESCs_Human	1.55250357
25	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.54278962
26	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.49570228
27	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.46259685
28	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.41839092
29	MYC_19829295_ChIP-Seq_ESCs_Human	1.41443485
30	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.40270472
31	RAC3_21632823_ChIP-Seq_H3396_Human	1.37107776
32	CBP_21632823_ChIP-Seq_H3396_Human	1.35488713
33	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.34941761
34	GBX2_23144817_ChIP-Seq_PC3_Human	1.33653428
35	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.32906072
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.31645797
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.31645797
38	OCT4_20526341_ChIP-Seq_ESCs_Human	1.29121794
39	ERA_21632823_ChIP-Seq_H3396_Human	1.28891175
40	TBX20_22328084_ChIP-Seq_HEART_Mouse	1.26127676
41	TBX20_22080862_ChIP-Seq_HEART_Mouse	1.26127676
42	SPI1_20517297_ChIP-Seq_HL60_Human	1.24109461
43	PHF8_20622853_ChIP-Seq_HELA_Human	1.21975631
44	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.21124735
45	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.18945731
46	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.17112649
47	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.16953556
48	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.13252378
49	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.12406812
50	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.11034019
51	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.10490106
52	SMC4_20622854_ChIP-Seq_HELA_Human	1.09139796
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08668196
54	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.08364855
55	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.07766652
56	NFYB_21822215_ChIP-Seq_K562_Human	1.07001626
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.06644840
58	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05487840
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04482835
60	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.03681036
61	E2F1_20622854_ChIP-Seq_HELA_Human	1.03301002
62	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02033162
63	CTCF_21964334_Chip-Seq_Bcells_Human	1.01954357
64	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99670508
65	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99670508
66	PHF8_20622854_ChIP-Seq_HELA_Human	0.96399564
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96297799
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96297799
69	NCOR_22424771_ChIP-Seq_293T_Human	0.94909971
70	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.94037496
71	TBL1_22424771_ChIP-Seq_293T_Human	0.93946011
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.93653581
73	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.93064512
74	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92264630
75	STAT1_20625510_ChIP-Seq_HELA_Human	0.91642898
76	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90307026
77	ETV1_20927104_ChIP-Seq_GIST48_Human	0.90050062
78	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89357906
79	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87904967
80	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.87865204
81	AR_21572438_ChIP-Seq_LNCaP_Human	0.86340772
82	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.86114053
83	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.85940690
84	OCT4_19829295_ChIP-Seq_ESCs_Human	0.85868134
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84930114
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.84624807
87	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.84390053
88	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.83905628
89	ZNF263_19887448_ChIP-Seq_K562_Human	0.83900780
90	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83070267
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.82610040
92	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.82541055
93	HOXB7_26014856_ChIP-Seq_BT474_Human	0.81953844
94	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.80665976
95	RBPJ_21746931_ChIP-Seq_IB4_Human	0.79622820
96	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.79494496
97	NFYA_21822215_ChIP-Seq_K562_Human	0.77575134
98	CEBPB_22108803_ChIP-Seq_LS180_Human	0.76983831
99	BCL6_27268052_Chip-Seq_Bcells_Human	0.75901656
100	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.75122218

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	6.49415742
2	MP0003646_muscle_fatigue	5.51867161
3	MP0004145_abnormal_muscle_electrophysio	5.12982214
4	MP0003806_abnormal_nucleotide_metabolis	4.17689186
5	MP0004036_abnormal_muscle_relaxation	3.95991939
6	MP0005451_abnormal_body_composition	3.70896322
7	MP0000751_myopathy	3.45653181
8	MP0004084_abnormal_cardiac_muscle	3.38494664
9	MP0002837_dystrophic_cardiac_calcinosis	3.38404204
10	MP0005330_cardiomyopathy	2.86483861
11	MP0002269_muscular_atrophy	2.84319808
12	MP0000759_abnormal_skeletal_muscle	2.67540510
13	MP0002106_abnormal_muscle_physiology	2.60892213
14	MP0004087_abnormal_muscle_fiber	2.49919455
15	MP0006036_abnormal_mitochondrial_physio	2.45936280
16	MP0005369_muscle_phenotype	2.45097888
17	MP0005360_urolithiasis	2.43101280
18	MP0000747_muscle_weakness	2.37123104
19	MP0005620_abnormal_muscle_contractility	2.30195014
20	MP0002108_abnormal_muscle_morphology	2.27721585
21	MP0010368_abnormal_lymphatic_system	2.10762122
22	MP0004233_abnormal_muscle_weight	2.10571900
23	MP0004215_abnormal_myocardial_fiber	2.03935314
24	MP0000750_abnormal_muscle_regeneration	2.03074904
25	MP0002160_abnormal_reproductive_system	1.90624636
26	MP0002332_abnormal_exercise_endurance	1.86717056
27	MP0005410_abnormal_fertilization	1.70412399
28	MP0001661_extended_life_span	1.69109715
29	MP0003315_abnormal_perineum_morphology	1.65687073
30	MP0004130_abnormal_muscle_cell	1.63710699
31	MP0000733_abnormal_muscle_development	1.63342894
32	MP0008004_abnormal_stomach_pH	1.57683695
33	MP0002972_abnormal_cardiac_muscle	1.57097870
34	MP0005266_abnormal_metabolism	1.54599790
35	MP0003879_abnormal_hair_cell	1.47675039
36	MP0009697_abnormal_copulation	1.46373558
37	MP0008877_abnormal_DNA_methylation	1.45521459
38	MP0002139_abnormal_hepatobiliary_system	1.45478710
39	MP0004510_myositis	1.36270808
40	MP0001929_abnormal_gametogenesis	1.33647311
41	MP0002127_abnormal_cardiovascular_syste	1.30897838
42	MP0004484_altered_response_of	1.28235156
43	MP0001544_abnormal_cardiovascular_syste	1.14319554
44	MP0005385_cardiovascular_system_phenoty	1.14319554
45	MP0002210_abnormal_sex_determination	1.14234619
46	MP0006138_congestive_heart_failure	1.12669747
47	MP0003698_abnormal_male_reproductive	1.11849802
48	MP0010630_abnormal_cardiac_muscle	1.09482021
49	MP0003718_maternal_effect	1.07783281
50	MP0008875_abnormal_xenobiotic_pharmacok	1.05413433
51	MP0000678_abnormal_parathyroid_gland	1.01304274
52	MP0001984_abnormal_olfaction	0.94810362
53	MP0005332_abnormal_amino_acid	0.94151605
54	MP0008775_abnormal_heart_ventricle	0.92118977
55	MP0000013_abnormal_adipose_tissue	0.88250043
56	MP0003045_fibrosis	0.87138272
57	MP0001764_abnormal_homeostasis	0.84002142
58	MP0003195_calcinosis	0.82135531
59	MP0005166_decreased_susceptibility_to	0.78547884
60	MP0005670_abnormal_white_adipose	0.78351566
61	MP0001145_abnormal_male_reproductive	0.78166483
62	MP0003950_abnormal_plasma_membrane	0.77461048
63	MP0000653_abnormal_sex_gland	0.75895234
64	MP0005389_reproductive_system_phenotype	0.74903233
65	MP0001485_abnormal_pinna_reflex	0.73730440
66	MP0009840_abnormal_foam_cell	0.72970061
67	MP0005376_homeostasis/metabolism_phenot	0.72140318
68	MP0005319_abnormal_enzyme/_coenzyme	0.70641147
69	MP0005058_abnormal_lysosome_morphology	0.70628375
70	MP0002971_abnormal_brown_adipose	0.67435889
71	MP0008789_abnormal_olfactory_epithelium	0.64584086
72	MP0001529_abnormal_vocalization	0.61388900
73	MP0002249_abnormal_larynx_morphology	0.61106470
74	MP0005187_abnormal_penis_morphology	0.58709898
75	MP0005085_abnormal_gallbladder_physiolo	0.58646606
76	MP0002138_abnormal_hepatobiliary_system	0.58053995
77	MP0010030_abnormal_orbit_morphology	0.57464373
78	MP0008058_abnormal_DNA_repair	0.56155745
79	MP0001879_abnormal_lymphatic_vessel	0.55894381
80	MP0009250_abnormal_appendicular_skeleto	0.55686627
81	MP0001986_abnormal_taste_sensitivity	0.55541545
82	MP0002161_abnormal_fertility/fecundity	0.53838180
83	MP0004270_analgesia	0.53120250
84	MP0002078_abnormal_glucose_homeostasis	0.52841657
85	MP0001664_abnormal_digestion	0.52744644
86	MP0005167_abnormal_blood-brain_barrier	0.51879403
87	MP0003868_abnormal_feces_composition	0.50475709
88	MP0004085_abnormal_heartbeat	0.50092835
89	MP0003693_abnormal_embryo_hatching	0.50047862
90	MP0000049_abnormal_middle_ear	0.49849876
91	MP0009780_abnormal_chondrocyte_physiolo	0.48975449
92	MP0001905_abnormal_dopamine_level	0.46813521
93	MP0000762_abnormal_tongue_morphology	0.44599597
94	MP0010386_abnormal_urinary_bladder	0.43834101
95	MP0002132_abnormal_respiratory_system	0.43162941
96	MP0008995_early_reproductive_senescence	0.42973607
97	MP0005647_abnormal_sex_gland	0.40822423
98	MP0000343_altered_response_to	0.37937368
99	MP0003699_abnormal_female_reproductive	0.37774986
100	MP0005334_abnormal_fat_pad	0.37238887

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle fiber inclusion bodies (HP:0100299)	9.39704077
2	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	9.09880365
3	Nemaline bodies (HP:0003798)	8.49570282
4	Exercise-induced myalgia (HP:0003738)	7.95780944
5	Exercise-induced muscle cramps (HP:0003710)	7.53305857
6	Type 1 muscle fiber predominance (HP:0003803)	6.05654081
7	Rimmed vacuoles (HP:0003805)	6.01298604
8	Muscle hypertrophy of the lower extremities (HP:0008968)	5.77512855
9	EMG: myopathic abnormalities (HP:0003458)	5.58586577
10	Distal arthrogryposis (HP:0005684)	5.56247966
11	Myopathic facies (HP:0002058)	5.49199474
12	Hyporeflexia of lower limbs (HP:0002600)	5.44860320
13	Calf muscle hypertrophy (HP:0008981)	5.34534070
14	Abnormality of the calf musculature (HP:0001430)	5.03765773
15	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.99649677
16	Rhabdomyolysis (HP:0003201)	4.87405773
17	Myoglobinuria (HP:0002913)	4.65230060
18	Muscle fiber splitting (HP:0003555)	4.62979269
19	Neck muscle weakness (HP:0000467)	4.55611285
20	Scapular winging (HP:0003691)	4.21679083
21	Abnormality of skeletal muscle fiber size (HP:0012084)	3.94501291
22	Abnormality of the shoulder girdle musculature (HP:0001435)	3.82224867
23	Round ear (HP:0100830)	3.72584216
24	Frequent falls (HP:0002359)	3.64081264
25	Bulbar palsy (HP:0001283)	3.58667063
26	Increased variability in muscle fiber diameter (HP:0003557)	3.43416253
27	Malignant hyperthermia (HP:0002047)	3.39607006
28	Sudden death (HP:0001699)	3.26684107
29	Muscle stiffness (HP:0003552)	3.25049219
30	Ulnar deviation of the wrist (HP:0003049)	3.21774577
31	Absent phalangeal crease (HP:0006109)	3.18171922
32	Spinal rigidity (HP:0003306)	3.15609198
33	Difficulty running (HP:0009046)	3.01878968
34	Abnormality of the left ventricular outflow tract (HP:0011103)	3.00386814
35	Subaortic stenosis (HP:0001682)	3.00386814
36	Weak cry (HP:0001612)	2.99908063
37	Calcaneovalgus deformity (HP:0001848)	2.81508906
38	Proximal amyotrophy (HP:0007126)	2.80904709
39	Clumsiness (HP:0002312)	2.71279372
40	Resting tremor (HP:0002322)	2.68100240
41	Areflexia of lower limbs (HP:0002522)	2.62024382
42	Abnormal finger flexion creases (HP:0006143)	2.57790794
43	Bundle branch block (HP:0011710)	2.57132572
44	Reduced antithrombin III activity (HP:0001976)	2.53250602
45	Dilated cardiomyopathy (HP:0001644)	2.52125388
46	Limb-girdle muscle atrophy (HP:0003797)	2.48788508
47	Deformed tarsal bones (HP:0008119)	2.45522827
48	Muscular dystrophy (HP:0003560)	2.43416497
49	Generalized muscle weakness (HP:0003324)	2.35371794
50	Abnormality of the foot musculature (HP:0001436)	2.25908977
51	Foot dorsiflexor weakness (HP:0009027)	2.25837043
52	Respiratory insufficiency due to muscle weakness (HP:0002747)	2.23367174
53	Nonprogressive disorder (HP:0003680)	2.23271821
54	Shoulder girdle muscle weakness (HP:0003547)	2.21587401
55	Gowers sign (HP:0003391)	2.19026145
56	Urinary urgency (HP:0000012)	2.17916369
57	Ventricular fibrillation (HP:0001663)	2.17890707
58	Myotonia (HP:0002486)	2.12850594
59	Increased connective tissue (HP:0009025)	2.09413471
60	Asymmetric septal hypertrophy (HP:0001670)	2.08301640
61	Diaphragmatic weakness (HP:0009113)	2.05270701
62	Right ventricular cardiomyopathy (HP:0011663)	2.03859649
63	Waddling gait (HP:0002515)	2.02818676
64	Fetal akinesia sequence (HP:0001989)	2.02734850
65	Hip contracture (HP:0003273)	1.96340724
66	Abnormality of the neuromuscular junction (HP:0003398)	1.96116871
67	Fatigable weakness (HP:0003473)	1.96116871
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95167513
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95167513
70	Lipoatrophy (HP:0100578)	1.92673717
71	Popliteal pterygium (HP:0009756)	1.87966473
72	Abnormality of the calcaneus (HP:0008364)	1.84731584
73	Long clavicles (HP:0000890)	1.83515153
74	EMG: neuropathic changes (HP:0003445)	1.83437027
75	Heart block (HP:0012722)	1.80722084
76	Difficulty walking (HP:0002355)	1.79860507
77	Prolonged partial thromboplastin time (HP:0003645)	1.70858967
78	Distal lower limb muscle weakness (HP:0009053)	1.70716262
79	Nasal speech (HP:0001611)	1.69601640
80	Difficulty climbing stairs (HP:0003551)	1.68835329
81	Type 2 muscle fiber atrophy (HP:0003554)	1.66613313
82	Short palpebral fissure (HP:0012745)	1.63166081
83	Exercise intolerance (HP:0003546)	1.63100964
84	Abnormal atrioventricular conduction (HP:0005150)	1.61744137
85	Mildly elevated creatine phosphokinase (HP:0008180)	1.61501301
86	Gout (HP:0001997)	1.61227603
87	Limb-girdle muscle weakness (HP:0003325)	1.61216605
88	Easy fatigability (HP:0003388)	1.60081732
89	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.59399771
90	Generalized aminoaciduria (HP:0002909)	1.58460607
91	Steppage gait (HP:0003376)	1.58409017
92	Generalized amyotrophy (HP:0003700)	1.57679209
93	Hyperkalemia (HP:0002153)	1.57194518
94	Aplastic anemia (HP:0001915)	1.54591240
95	Slender build (HP:0001533)	1.52211583
96	Increased muscle lipid content (HP:0009058)	1.51853060
97	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.51250424
98	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.50693612
99	Progressive muscle weakness (HP:0003323)	1.49395092
100	Facial diplegia (HP:0001349)	1.48085711

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	9.65969351
2	PINK1	8.38726652
3	PHKG2	4.25566964
4	PHKG1	4.25566964
5	MARK3	3.02658043
6	TTN	2.85535760
7	STK16	2.17636069
8	MUSK	1.88729272
9	PIK3CG	1.66304187
10	MAP3K1	1.39479152
11	LATS1	1.28589342
12	MAP3K7	1.22090157
13	MAP3K9	1.14340832
14	TLK1	1.13103908
15	MAPK12	1.11434668
16	NME1	1.10704350
17	MAP3K13	1.10052266
18	MST1R	1.01901045
19	NEK9	1.00016874
20	ZAK	0.98085545
21	STK38L	0.88448837
22	ARAF	0.87862567
23	CCNB1	0.74976255
24	BRAF	0.74901025
25	TXK	0.74665966
26	PRKG2	0.72698712
27	RPS6KB1	0.72338420
28	NME2	0.71515475
29	CLK1	0.71272186
30	NEK1	0.68593711
31	TIE1	0.65662068
32	MOS	0.64991514
33	AKT2	0.63992118
34	NEK2	0.63856619
35	EIF2AK3	0.63224399
36	LATS2	0.61867796
37	PLK1	0.60292369
38	MAPKAPK3	0.58181706
39	CDK8	0.56894210
40	PRKG1	0.56651415
41	PNCK	0.55522822
42	MAP2K7	0.52413903
43	MET	0.51998393
44	PKN1	0.50771914
45	BMPR1B	0.50588656
46	TRPM7	0.49402292
47	MAP2K3	0.49220311
48	MYLK	0.48202724
49	SGK494	0.48029738
50	SGK223	0.48029738
51	ROCK1	0.46374419
52	SGK2	0.46292122
53	PRKAA2	0.45929461
54	MELK	0.45675142
55	STK24	0.44496766
56	GRK7	0.44126756
57	TTK	0.43795581
58	CAMK2G	0.43524393
59	BCKDK	0.43466935
60	PRKAA1	0.40545940
61	NLK	0.38160040
62	EEF2K	0.37403978
63	ICK	0.37150960
64	MAP2K4	0.36748567
65	PBK	0.36134656
66	KSR2	0.35074593
67	PAK1	0.34374123
68	CSNK1A1L	0.33977283
69	CSNK1G1	0.31480825
70	SGK3	0.31281693
71	CDK19	0.30779570
72	CSNK1G3	0.30614960
73	FRK	0.30360652
74	PLK4	0.29965774
75	AURKB	0.29835213
76	MAPK7	0.29450173
77	ADRBK2	0.27862032
78	LIMK1	0.27455907
79	AURKA	0.27451689
80	MAP3K10	0.26936973
81	DYRK1B	0.26725671
82	RPS6KA1	0.25897248
83	WEE1	0.25896458
84	CDK14	0.25360210
85	STK3	0.24751875
86	CDK9	0.24542267
87	PRKCQ	0.24326755
88	CSNK1G2	0.24319259
89	PTK2B	0.24148987
90	CAMK1	0.24137670
91	IRAK2	0.23212999
92	MAPK11	0.22647628
93	PRKACA	0.22612028
94	STK38	0.22010441
95	PRKACB	0.19710400
96	OXSR1	0.19517697
97	MTOR	0.19478016
98	RPS6KA5	0.18410072
99	SGK1	0.18288613
100	ACVR1B	0.17876799

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.25515848
2	Arginine biosynthesis_Homo sapiens_hsa00220	2.86407059
3	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.71653190
4	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.67519604
5	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.26235684
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.23723984
7	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.20746806
8	Caffeine metabolism_Homo sapiens_hsa00232	2.20556048
9	Fatty acid degradation_Homo sapiens_hsa00071	2.15822226
10	Propanoate metabolism_Homo sapiens_hsa00640	2.15522578
11	Circadian rhythm_Homo sapiens_hsa04710	2.08773340
12	Phenylalanine metabolism_Homo sapiens_hsa00360	2.08579771
13	Cardiac muscle contraction_Homo sapiens_hsa04260	2.05425676
14	Chemical carcinogenesis_Homo sapiens_hsa05204	2.03099958
15	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.96481181
16	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.90407736
17	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.90068952
18	Arginine and proline metabolism_Homo sapiens_hsa00330	1.83973010
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.79288117
20	Retinol metabolism_Homo sapiens_hsa00830	1.76235933
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.74316849
22	Histidine metabolism_Homo sapiens_hsa00340	1.70280029
23	Butanoate metabolism_Homo sapiens_hsa00650	1.67178672
24	Glucagon signaling pathway_Homo sapiens_hsa04922	1.65592503
25	Pentose phosphate pathway_Homo sapiens_hsa00030	1.60711014
26	Tyrosine metabolism_Homo sapiens_hsa00350	1.59000258
27	Pyruvate metabolism_Homo sapiens_hsa00620	1.57163396
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52242967
29	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.51936485
30	Carbon metabolism_Homo sapiens_hsa01200	1.51851792
31	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.50829440
32	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.43234232
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.41126239
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32909108
35	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.31999089
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30961035
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.30058526
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.28971551
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.28278623
40	Parkinsons disease_Homo sapiens_hsa05012	1.27761117
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.27481564
42	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23994756
43	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.22339012
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15816687
45	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15436924
46	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.13682924
47	Insulin signaling pathway_Homo sapiens_hsa04910	1.13499575
48	Calcium signaling pathway_Homo sapiens_hsa04020	1.11998865
49	Complement and coagulation cascades_Homo sapiens_hsa04610	1.09882035
50	Olfactory transduction_Homo sapiens_hsa04740	1.09623209
51	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.05865193
52	Peroxisome_Homo sapiens_hsa04146	1.00563911
53	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.94267384
54	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.93705246
55	PPAR signaling pathway_Homo sapiens_hsa03320	0.93217343
56	Sulfur relay system_Homo sapiens_hsa04122	0.91372449
57	AMPK signaling pathway_Homo sapiens_hsa04152	0.89490130
58	Alzheimers disease_Homo sapiens_hsa05010	0.87374132
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.81468285
60	Regulation of autophagy_Homo sapiens_hsa04140	0.80953331
61	Oocyte meiosis_Homo sapiens_hsa04114	0.80749111
62	Insulin resistance_Homo sapiens_hsa04931	0.80691724
63	Purine metabolism_Homo sapiens_hsa00230	0.80185118
64	Mineral absorption_Homo sapiens_hsa04978	0.79696962
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72669713
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68330666
67	Gap junction_Homo sapiens_hsa04540	0.68264632
68	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.68217119
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.67093341
70	Bile secretion_Homo sapiens_hsa04976	0.64995353
71	Oxidative phosphorylation_Homo sapiens_hsa00190	0.63846831
72	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.63277172
73	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.60193568
74	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59581324
75	ABC transporters_Homo sapiens_hsa02010	0.59271191
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.57139367
77	Glutathione metabolism_Homo sapiens_hsa00480	0.56514998
78	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.55850872
79	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.55723522
80	Metabolic pathways_Homo sapiens_hsa01100	0.55145752
81	Basal transcription factors_Homo sapiens_hsa03022	0.54609523
82	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.53541534
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51238313
84	Homologous recombination_Homo sapiens_hsa03440	0.51022920
85	Huntingtons disease_Homo sapiens_hsa05016	0.50344035
86	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48496164
87	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.46912386
88	One carbon pool by folate_Homo sapiens_hsa00670	0.45465343
89	Gastric acid secretion_Homo sapiens_hsa04971	0.44292518
90	Mismatch repair_Homo sapiens_hsa03430	0.43743752
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.42401853
92	DNA replication_Homo sapiens_hsa03030	0.41760650
93	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.38028821
94	RNA degradation_Homo sapiens_hsa03018	0.37422013
95	Phototransduction_Homo sapiens_hsa04744	0.37323778
96	Nucleotide excision repair_Homo sapiens_hsa03420	0.36373105
97	Ribosome_Homo sapiens_hsa03010	0.35436829
98	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.34712172
99	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32031123
100	Renin secretion_Homo sapiens_hsa04924	0.30894043

KRT17P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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