ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	5.54021362
2	synapsis (GO:0007129)	5.26844994
3	piRNA metabolic process (GO:0034587)	5.24226154
4	epithelial cilium movement (GO:0003351)	4.29949035
5	multicellular organism reproduction (GO:0032504)	4.27060852
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.23429862
7	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.03697380
8	L-fucose catabolic process (GO:0042355)	3.96711089
9	fucose catabolic process (GO:0019317)	3.96711089
10	L-fucose metabolic process (GO:0042354)	3.96711089
11	cilium or flagellum-dependent cell motility (GO:0001539)	3.95781393
12	sperm motility (GO:0030317)	3.94676242
13	response to pheromone (GO:0019236)	3.91495812
14	platelet dense granule organization (GO:0060155)	3.81801255
15	chromosome organization involved in meiosis (GO:0070192)	3.77673205
16	positive regulation of catecholamine secretion (GO:0033605)	3.72571990
17	acrosome reaction (GO:0007340)	3.71574691
18	regulation of cilium movement (GO:0003352)	3.71244697
19	male meiosis I (GO:0007141)	3.71028341
20	indole-containing compound catabolic process (GO:0042436)	3.67973744
21	indolalkylamine catabolic process (GO:0046218)	3.67973744
22	tryptophan catabolic process (GO:0006569)	3.67973744
23	behavioral response to nicotine (GO:0035095)	3.65221203
24	spermatid development (GO:0007286)	3.64047604
25	S-adenosylmethionine metabolic process (GO:0046500)	3.60560597
26	DNA deamination (GO:0045006)	3.59806178
27	DNA double-strand break processing (GO:0000729)	3.59670014
28	arginine catabolic process (GO:0006527)	3.57800406
29	regulation of meiosis I (GO:0060631)	3.54547892
30	sperm-egg recognition (GO:0035036)	3.54046931
31	indolalkylamine metabolic process (GO:0006586)	3.52956017
32	intraciliary transport (GO:0042073)	3.51583937
33	photoreceptor cell maintenance (GO:0045494)	3.46184287
34	meiotic nuclear division (GO:0007126)	3.43508802
35	replication fork processing (GO:0031297)	3.43165808
36	cellular ketone body metabolic process (GO:0046950)	3.37739792
37	seminiferous tubule development (GO:0072520)	3.36990520
38	cytochrome complex assembly (GO:0017004)	3.31504933
39	protein polyglutamylation (GO:0018095)	3.30938821
40	respiratory chain complex IV assembly (GO:0008535)	3.28227311
41	behavioral response to ethanol (GO:0048149)	3.21335275
42	cilium movement (GO:0003341)	3.19731674
43	axoneme assembly (GO:0035082)	3.19720155
44	neural tube formation (GO:0001841)	3.18968501
45	organic cation transport (GO:0015695)	3.18034498
46	ketone body metabolic process (GO:1902224)	3.17328743
47	DNA methylation involved in gamete generation (GO:0043046)	3.13074520
48	meiosis I (GO:0007127)	3.12760361
49	protein complex biogenesis (GO:0070271)	3.12287933
50	detection of light stimulus involved in visual perception (GO:0050908)	3.09662913
51	detection of light stimulus involved in sensory perception (GO:0050962)	3.09662913
52	binding of sperm to zona pellucida (GO:0007339)	3.06635362
53	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.04870949
54	cilium morphogenesis (GO:0060271)	2.99447827
55	cell-cell recognition (GO:0009988)	2.98862804
56	amine catabolic process (GO:0009310)	2.98002368
57	cellular biogenic amine catabolic process (GO:0042402)	2.98002368
58	synaptonemal complex organization (GO:0070193)	2.94459940
59	cilium organization (GO:0044782)	2.91748836
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89481656
61	mannosylation (GO:0097502)	2.89272705
62	synaptonemal complex assembly (GO:0007130)	2.86290408
63	axonemal dynein complex assembly (GO:0070286)	2.84458244
64	cilium assembly (GO:0042384)	2.84290345
65	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.82485682
66	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.82485682
67	NADH dehydrogenase complex assembly (GO:0010257)	2.82485682
68	positive regulation of mitochondrial fission (GO:0090141)	2.81614585
69	cell wall macromolecule catabolic process (GO:0016998)	2.79416611
70	tryptophan metabolic process (GO:0006568)	2.78185293
71	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.77434373
72	coenzyme catabolic process (GO:0009109)	2.77312186
73	recombinational repair (GO:0000725)	2.76679816
74	retinal cone cell development (GO:0046549)	2.76039993
75	resolution of meiotic recombination intermediates (GO:0000712)	2.75954456
76	reciprocal meiotic recombination (GO:0007131)	2.74052565
77	reciprocal DNA recombination (GO:0035825)	2.74052565
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.72221190
79	double-strand break repair via homologous recombination (GO:0000724)	2.71572915
80	dopamine transport (GO:0015872)	2.71506188
81	signal peptide processing (GO:0006465)	2.71288564
82	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66740002
83	regulation of oxidative stress-induced neuron death (GO:1903203)	2.66718013
84	response to nitrosative stress (GO:0051409)	2.62976425
85	protein K11-linked deubiquitination (GO:0035871)	2.59582252
86	lactate metabolic process (GO:0006089)	2.58779158
87	single fertilization (GO:0007338)	2.58528415
88	regulation of acrosome reaction (GO:0060046)	2.57482760
89	DNA integration (GO:0015074)	2.57397637
90	acrosome assembly (GO:0001675)	2.56051002
91	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.53670799
92	regulation of hexokinase activity (GO:1903299)	2.53469824
93	regulation of glucokinase activity (GO:0033131)	2.53469824
94	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.53337268
95	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.49733475
96	cell wall macromolecule metabolic process (GO:0044036)	2.48283492
97	reproduction (GO:0000003)	2.47791195
98	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.45915030
99	histone H2A acetylation (GO:0043968)	2.44908835
100	ubiquinone biosynthetic process (GO:0006744)	2.42955030

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.18976719
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75074132
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.17072533
4	VDR_22108803_ChIP-Seq_LS180_Human	3.16570956
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.85526510
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.61403623
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.46149203
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.43892400
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42098521
10	FUS_26573619_Chip-Seq_HEK293_Human	2.40006363
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.32059899
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.30435227
13	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.28467061
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.21699555
15	BCAT_22108803_ChIP-Seq_LS180_Human	2.20121738
16	P300_19829295_ChIP-Seq_ESCs_Human	2.19708964
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.02846462
18	EWS_26573619_Chip-Seq_HEK293_Human	1.93912453
19	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.93460078
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.93460078
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91201578
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.87065185
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.78530194
24	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.74296474
25	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.70706787
26	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68158436
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.67515083
28	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.62428603
29	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.61532218
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61517511
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.61424221
32	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.59282372
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59251243
34	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.57066591
35	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.55998199
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55618144
37	STAT3_23295773_ChIP-Seq_U87_Human	1.53909626
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.53817768
39	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.53817768
40	SOX2_19829295_ChIP-Seq_ESCs_Human	1.53063056
41	NANOG_19829295_ChIP-Seq_ESCs_Human	1.53063056
42	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49867902
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.47532220
44	AR_25329375_ChIP-Seq_VCAP_Human	1.46646733
45	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.46107070
46	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.44273035
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.38333010
48	TCF4_23295773_ChIP-Seq_U87_Human	1.36339666
49	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35478484
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.34860797
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.34114913
52	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.31586037
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31317799
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27843264
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.26641636
56	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.23113261
57	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22731886
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22490730
59	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.22432104
60	CDX2_22108803_ChIP-Seq_LS180_Human	1.21575188
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21352171
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.21302026
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21221166
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.20812784
65	AR_21572438_ChIP-Seq_LNCaP_Human	1.19756245
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19307467
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18684631
68	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17643413
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17595911
70	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.17247535
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.17247535
72	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.15954621
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.15898200
74	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15504719
75	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15307626
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14022117
77	AR_20517297_ChIP-Seq_VCAP_Human	1.13097831
78	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.12497919
79	NCOR_22424771_ChIP-Seq_293T_Human	1.12271635
80	VDR_23849224_ChIP-Seq_CD4+_Human	1.10879697
81	GATA3_26560356_Chip-Seq_TH2_Human	1.10464186
82	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.09967446
83	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.09566073
84	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08466317
85	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08317845
86	MYC_18940864_ChIP-ChIP_HL60_Human	1.05313698
87	MYC_19829295_ChIP-Seq_ESCs_Human	1.04943730
88	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04788559
89	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.03448423
90	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00091359
91	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	0.99822599
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98447722
93	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98320086
94	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97710634
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97705935
96	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.97057891
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96709103
98	RXR_22108803_ChIP-Seq_LS180_Human	0.95683584
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95141417
100	TBL1_22424771_ChIP-Seq_293T_Human	0.94933604

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	5.09875729
2	MP0000372_irregular_coat_pigmentation	3.27297115
3	MP0005410_abnormal_fertilization	3.21657221
4	MP0008877_abnormal_DNA_methylation	2.81443725
5	MP0005174_abnormal_tail_pigmentation	2.52095559
6	MP0002837_dystrophic_cardiac_calcinosis	2.40632064
7	MP0000015_abnormal_ear_pigmentation	2.37211666
8	MP0001968_abnormal_touch/_nociception	2.32824197
9	MP0002876_abnormal_thyroid_physiology	2.29293468
10	MP0005551_abnormal_eye_electrophysiolog	2.21176879
11	MP0001984_abnormal_olfaction	2.14728328
12	MP0000749_muscle_degeneration	2.06835744
13	MP0002102_abnormal_ear_morphology	2.02981113
14	MP0001529_abnormal_vocalization	1.98242875
15	MP0003787_abnormal_imprinting	1.94893823
16	MP0003880_abnormal_central_pattern	1.90777070
17	MP0004084_abnormal_cardiac_muscle	1.85853440
18	MP0001929_abnormal_gametogenesis	1.84745882
19	MP0003045_fibrosis	1.83949677
20	MP0001485_abnormal_pinna_reflex	1.83762346
21	MP0002160_abnormal_reproductive_system	1.82977334
22	MP0005075_abnormal_melanosome_morpholog	1.76590723
23	MP0002138_abnormal_hepatobiliary_system	1.76432083
24	MP0005253_abnormal_eye_physiology	1.73730375
25	MP0003698_abnormal_male_reproductive	1.71189808
26	MP0001501_abnormal_sleep_pattern	1.69441261
27	MP0003806_abnormal_nucleotide_metabolis	1.66979480
28	MP0003136_yellow_coat_color	1.64656457
29	MP0003950_abnormal_plasma_membrane	1.58745963
30	MP0005646_abnormal_pituitary_gland	1.58668837
31	MP0003195_calcinosis	1.58355392
32	MP0005670_abnormal_white_adipose	1.54515297
33	MP0008058_abnormal_DNA_repair	1.52201731
34	MP0004147_increased_porphyrin_level	1.50473583
35	MP0003646_muscle_fatigue	1.46585014
36	MP0002736_abnormal_nociception_after	1.45348903
37	MP0005645_abnormal_hypothalamus_physiol	1.44640026
38	MP0002938_white_spotting	1.44148977
39	MP0000427_abnormal_hair_cycle	1.43769591
40	MP0006072_abnormal_retinal_apoptosis	1.42194771
41	MP0005084_abnormal_gallbladder_morpholo	1.41094166
42	MP0010368_abnormal_lymphatic_system	1.40069239
43	MP0002095_abnormal_skin_pigmentation	1.39872420
44	MP0006276_abnormal_autonomic_nervous	1.36847140
45	MP0005171_absent_coat_pigmentation	1.36616885
46	MP0001986_abnormal_taste_sensitivity	1.35681531
47	MP0002234_abnormal_pharynx_morphology	1.31137610
48	MP0004145_abnormal_muscle_electrophysio	1.30050787
49	MP0008995_early_reproductive_senescence	1.27519816
50	MP0001764_abnormal_homeostasis	1.26176459
51	MP0005360_urolithiasis	1.23660943
52	MP0002168_other_aberrant_phenotype	1.19416253
53	MP0009745_abnormal_behavioral_response	1.19024463
54	MP0001486_abnormal_startle_reflex	1.17732966
55	MP0002210_abnormal_sex_determination	1.14931992
56	MP0003718_maternal_effect	1.14244570
57	MP0009046_muscle_twitch	1.14087803
58	MP0005386_behavior/neurological_phenoty	1.13348902
59	MP0004924_abnormal_behavior	1.13348902
60	MP0006054_spinal_hemorrhage	1.08680601
61	MP0006036_abnormal_mitochondrial_physio	1.08447768
62	MP0004215_abnormal_myocardial_fiber	1.08365672
63	MP0005389_reproductive_system_phenotype	1.08126552
64	MP0002272_abnormal_nervous_system	1.07748852
65	MP0008875_abnormal_xenobiotic_pharmacok	1.05837570
66	MP0000653_abnormal_sex_gland	1.05647773
67	MP0008872_abnormal_physiological_respon	1.03685898
68	MP0005395_other_phenotype	1.03275207
69	MP0005167_abnormal_blood-brain_barrier	1.01119221
70	MP0010386_abnormal_urinary_bladder	1.00651127
71	MP0005647_abnormal_sex_gland	0.98574193
72	MP0001145_abnormal_male_reproductive	0.97089508
73	MP0002638_abnormal_pupillary_reflex	0.96535637
74	MP0001664_abnormal_digestion	0.94992846
75	MP0002751_abnormal_autonomic_nervous	0.92325709
76	MP0004036_abnormal_muscle_relaxation	0.91729693
77	MP0002282_abnormal_trachea_morphology	0.89164319
78	MP0002163_abnormal_gland_morphology	0.88720642
79	MP0001963_abnormal_hearing_physiology	0.87705712
80	MP0001905_abnormal_dopamine_level	0.87559469
81	MP0004085_abnormal_heartbeat	0.85857258
82	MP0002067_abnormal_sensory_capabilities	0.85601839
83	MP0003315_abnormal_perineum_morphology	0.83096721
84	MP0005332_abnormal_amino_acid	0.82705946
85	MP0000230_abnormal_systemic_arterial	0.82344951
86	MP0000631_abnormal_neuroendocrine_gland	0.81506342
87	MP0001324_abnormal_eye_pigmentation	0.81042779
88	MP0005187_abnormal_penis_morphology	0.80739945
89	MP0008775_abnormal_heart_ventricle	0.80315920
90	MP0003633_abnormal_nervous_system	0.79847939
91	MP0000538_abnormal_urinary_bladder	0.79420711
92	MP0002733_abnormal_thermal_nociception	0.78916934
93	MP0004381_abnormal_hair_follicle	0.76138272
94	MP0001119_abnormal_female_reproductive	0.75477432
95	MP0002090_abnormal_vision	0.74648960
96	MP0004043_abnormal_pH_regulation	0.73938083
97	MP0001970_abnormal_pain_threshold	0.73824940
98	MP0006035_abnormal_mitochondrial_morpho	0.72365172
99	MP0005310_abnormal_salivary_gland	0.72014840
100	MP0003137_abnormal_impulse_conducting	0.71282540

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.90562017
2	Type II lissencephaly (HP:0007260)	3.78713938
3	Pancreatic fibrosis (HP:0100732)	3.53569322
4	True hermaphroditism (HP:0010459)	3.41906543
5	Cerebellar dysplasia (HP:0007033)	3.41581395
6	Inability to walk (HP:0002540)	3.25718870
7	Retinal dysplasia (HP:0007973)	3.21198531
8	Tubulointerstitial nephritis (HP:0001970)	3.17674188
9	Volvulus (HP:0002580)	3.15253129
10	Pancreatic islet-cell hyperplasia (HP:0004510)	3.12309822
11	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.08967475
12	Intestinal atresia (HP:0011100)	3.07442479
13	Absent speech (HP:0001344)	3.03549368
14	Abnormality of midbrain morphology (HP:0002418)	2.99231162
15	Molar tooth sign on MRI (HP:0002419)	2.99231162
16	Abnormality of the renal cortex (HP:0011035)	2.93181636
17	Type 2 muscle fiber atrophy (HP:0003554)	2.82073030
18	Thyroid-stimulating hormone excess (HP:0002925)	2.81485623
19	Renal cortical cysts (HP:0000803)	2.78919484
20	Fair hair (HP:0002286)	2.72530158
21	Occipital encephalocele (HP:0002085)	2.70575029
22	Hyperventilation (HP:0002883)	2.70021724
23	Nephronophthisis (HP:0000090)	2.67635306
24	Attenuation of retinal blood vessels (HP:0007843)	2.67186832
25	Congenital stationary night blindness (HP:0007642)	2.62817320
26	Abnormality of the renal medulla (HP:0100957)	2.57788881
27	Progressive inability to walk (HP:0002505)	2.55842037
28	Cystic liver disease (HP:0006706)	2.54027296
29	Abnormality of macular pigmentation (HP:0008002)	2.52206597
30	Abnormality of the ileum (HP:0001549)	2.49195881
31	Progressive macrocephaly (HP:0004481)	2.45738245
32	Chronic hepatic failure (HP:0100626)	2.44715521
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44563232
34	Absent/shortened dynein arms (HP:0200106)	2.44563232
35	Acute necrotizing encephalopathy (HP:0006965)	2.42688915
36	Protruding tongue (HP:0010808)	2.42124308
37	Hypothermia (HP:0002045)	2.36236206
38	Facial diplegia (HP:0001349)	2.36222619
39	Methylmalonic acidemia (HP:0002912)	2.33809007
40	Hypoproteinemia (HP:0003075)	2.33564020
41	Male pseudohermaphroditism (HP:0000037)	2.31711568
42	Abnormal rod and cone electroretinograms (HP:0008323)	2.30358301
43	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.29586185
44	Abnormal protein N-linked glycosylation (HP:0012347)	2.29586185
45	Abnormal protein glycosylation (HP:0012346)	2.29586185
46	Abnormal glycosylation (HP:0012345)	2.29586185
47	Retinal atrophy (HP:0001105)	2.28525529
48	Reduced antithrombin III activity (HP:0001976)	2.27592742
49	Generalized hypopigmentation of hair (HP:0011358)	2.27097990
50	Abolished electroretinogram (ERG) (HP:0000550)	2.26140013
51	Abnormal mitochondria in muscle tissue (HP:0008316)	2.24235410
52	Large for gestational age (HP:0001520)	2.23924188
53	Abnormality of endocrine pancreas physiology (HP:0012093)	2.22954318
54	Abnormality of the pancreatic islet cells (HP:0006476)	2.22954318
55	Hyperglycinemia (HP:0002154)	2.19969137
56	Decreased central vision (HP:0007663)	2.19654844
57	Mitochondrial inheritance (HP:0001427)	2.19240436
58	Acute encephalopathy (HP:0006846)	2.19194361
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15530324
60	Keratoconus (HP:0000563)	2.12675233
61	Increased corneal curvature (HP:0100692)	2.12675233
62	Congenital sensorineural hearing impairment (HP:0008527)	2.12431349
63	Severe visual impairment (HP:0001141)	2.09577284
64	Clumsiness (HP:0002312)	2.09461832
65	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.08578814
66	Muscle fiber atrophy (HP:0100295)	2.07775937
67	Congenital hepatic fibrosis (HP:0002612)	2.06819075
68	Increased CSF lactate (HP:0002490)	2.06484016
69	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06260997
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.03847477
71	Sclerocornea (HP:0000647)	2.01999362
72	Tubular atrophy (HP:0000092)	2.01533864
73	Albinism (HP:0001022)	2.00604185
74	Meckel diverticulum (HP:0002245)	2.00049249
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97731704
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.97731704
77	Febrile seizures (HP:0002373)	1.97353628
78	3-Methylglutaconic aciduria (HP:0003535)	1.96555125
79	Gaze-evoked nystagmus (HP:0000640)	1.94407033
80	Widely spaced teeth (HP:0000687)	1.92741338
81	Ketosis (HP:0001946)	1.92553593
82	Methylmalonic aciduria (HP:0012120)	1.91823280
83	Anencephaly (HP:0002323)	1.90985699
84	Clubbing of toes (HP:0100760)	1.90873996
85	Chromsome breakage (HP:0040012)	1.90013010
86	Lissencephaly (HP:0001339)	1.87124650
87	Hepatocellular necrosis (HP:0001404)	1.85793417
88	Ketoacidosis (HP:0001993)	1.84492418
89	Small hand (HP:0200055)	1.83092582
90	Tubulointerstitial abnormality (HP:0001969)	1.81972958
91	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.81863537
92	Eosinophilia (HP:0001880)	1.80307287
93	Type I transferrin isoform profile (HP:0003642)	1.79668123
94	Abnormal ciliary motility (HP:0012262)	1.79319223
95	Aplasia/hypoplasia of the uterus (HP:0008684)	1.78215015
96	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76704117
97	Abnormal biliary tract physiology (HP:0012439)	1.75893925
98	Bile duct proliferation (HP:0001408)	1.75893925
99	Tented upper lip vermilion (HP:0010804)	1.74946717
100	Optic nerve hypoplasia (HP:0000609)	1.73651957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.12254859
2	FRK	4.89672717
3	INSRR	3.99928747
4	MAP4K2	2.84098256
5	ADRBK2	2.62444956
6	NUAK1	2.57968005
7	MUSK	2.47142136
8	MARK3	2.23879256
9	WNK3	2.23364035
10	EIF2AK3	2.21360812
11	TRIM28	2.06649001
12	MAPK13	2.04207902
13	BCR	1.99803068
14	ZAK	1.99361227
15	BMPR1B	1.89851429
16	LATS1	1.86537718
17	PAK3	1.54079066
18	STK3	1.43419852
19	KDR	1.38939837
20	OBSCN	1.35443092
21	CCNB1	1.30518604
22	GRK1	1.28335529
23	BCKDK	1.26916113
24	WEE1	1.25397517
25	TLK1	1.24145102
26	PRKD3	1.21225374
27	ERBB3	1.19129536
28	CSNK1G3	1.11828239
29	MST4	1.10999034
30	BRSK2	1.09399464
31	CSNK1A1L	1.05782900
32	PTK2B	1.05593560
33	RPS6KA5	1.04912050
34	FER	1.03730313
35	PLK2	1.02218065
36	CSNK1G1	1.01363896
37	CSNK1G2	0.98754499
38	PLK4	0.93028257
39	PRKCE	0.92078347
40	PKN1	0.88673246
41	OXSR1	0.86828148
42	MKNK2	0.83126306
43	PLK3	0.81033947
44	VRK1	0.80409484
45	MYLK	0.79556040
46	CASK	0.78224120
47	NEK2	0.77161086
48	PDK2	0.75696479
49	DYRK2	0.75691876
50	STK38L	0.74831941
51	MARK1	0.73039820
52	TIE1	0.72925308
53	ADRBK1	0.72847149
54	EPHA3	0.70395409
55	TXK	0.69759801
56	EPHA4	0.65755376
57	TAOK3	0.63337860
58	MAPKAPK3	0.62242661
59	MET	0.57803851
60	STK39	0.56464962
61	NEK1	0.55871167
62	BUB1	0.55517736
63	PRKCQ	0.54598149
64	CLK1	0.50472837
65	EIF2AK2	0.47846168
66	CSNK1A1	0.46987465
67	TNIK	0.46926565
68	PLK1	0.45582643
69	MINK1	0.44320128
70	ROCK1	0.44187887
71	CDK3	0.43113516
72	LIMK1	0.42729226
73	WNK4	0.42645619
74	CAMK2A	0.42242956
75	ATM	0.41555004
76	PRKCI	0.40689240
77	TGFBR1	0.40663215
78	ACVR1B	0.40351785
79	ITK	0.38845425
80	PRKCG	0.37530611
81	FGFR2	0.36384723
82	DAPK1	0.35765540
83	KIT	0.35444002
84	ABL1	0.35090891
85	MAP3K4	0.34526185
86	PHKG2	0.34234176
87	PHKG1	0.34234176
88	PRKG1	0.33688985
89	PIK3CA	0.33512787
90	FLT3	0.32360727
91	ATR	0.31672811
92	CSNK1D	0.31440552
93	SRPK1	0.30775424
94	MAP2K7	0.30453876
95	IKBKB	0.30060031
96	GRK5	0.27273723
97	RPS6KA4	0.26998969
98	NTRK2	0.26752822
99	TEC	0.25525203
100	PRKACA	0.24859020

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.76330051
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.27009328
3	Butanoate metabolism_Homo sapiens_hsa00650	3.21615176
4	Propanoate metabolism_Homo sapiens_hsa00640	3.18272668
5	Homologous recombination_Homo sapiens_hsa03440	2.30482185
6	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.21857278
7	Phototransduction_Homo sapiens_hsa04744	2.16891654
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08253803
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.07509349
10	Basal transcription factors_Homo sapiens_hsa03022	2.02197126
11	Fanconi anemia pathway_Homo sapiens_hsa03460	1.99379215
12	Proteasome_Homo sapiens_hsa03050	1.91871882
13	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.91540841
14	Non-homologous end-joining_Homo sapiens_hsa03450	1.91284815
15	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.77364512
16	Olfactory transduction_Homo sapiens_hsa04740	1.77017649
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.71537035
18	Regulation of autophagy_Homo sapiens_hsa04140	1.70615200
19	Protein export_Homo sapiens_hsa03060	1.69895247
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.66890842
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.56997305
22	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.55210956
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.53852235
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.53276273
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.52415501
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.43763063
27	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.35100814
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.30129950
29	ABC transporters_Homo sapiens_hsa02010	1.26660639
30	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22354351
31	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.20590257
32	RNA degradation_Homo sapiens_hsa03018	1.19633740
33	Peroxisome_Homo sapiens_hsa04146	1.19501969
34	Taste transduction_Homo sapiens_hsa04742	1.13750987
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12568667
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.11777252
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.09723137
38	Caffeine metabolism_Homo sapiens_hsa00232	1.08092724
39	Purine metabolism_Homo sapiens_hsa00230	1.06712921
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05724056
41	Circadian rhythm_Homo sapiens_hsa04710	1.03281225
42	RNA polymerase_Homo sapiens_hsa03020	1.01905165
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01107157
44	Parkinsons disease_Homo sapiens_hsa05012	0.99043814
45	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.97795236
46	Oxidative phosphorylation_Homo sapiens_hsa00190	0.94905319
47	Sulfur metabolism_Homo sapiens_hsa00920	0.93869324
48	Fatty acid degradation_Homo sapiens_hsa00071	0.93222108
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.92647580
50	Glutathione metabolism_Homo sapiens_hsa00480	0.92462541
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.90952187
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.81084429
53	Nicotine addiction_Homo sapiens_hsa05033	0.80432293
54	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79326588
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.77485311
56	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77334930
57	Allograft rejection_Homo sapiens_hsa05330	0.74602577
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.72649299
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72152763
60	Retinol metabolism_Homo sapiens_hsa00830	0.71466299
61	Metabolic pathways_Homo sapiens_hsa01100	0.67054589
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64916653
63	Fatty acid metabolism_Homo sapiens_hsa01212	0.64698427
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63343755
65	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63206370
66	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61649720
67	Histidine metabolism_Homo sapiens_hsa00340	0.59397493
68	Antigen processing and presentation_Homo sapiens_hsa04612	0.58325689
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.58005632
70	Circadian entrainment_Homo sapiens_hsa04713	0.57169081
71	Huntingtons disease_Homo sapiens_hsa05016	0.55958879
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53275191
73	Oocyte meiosis_Homo sapiens_hsa04114	0.52837329
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.50649614
75	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50572001
76	Morphine addiction_Homo sapiens_hsa05032	0.50364075
77	Steroid biosynthesis_Homo sapiens_hsa00100	0.49964252
78	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49810839
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.49003010
80	Calcium signaling pathway_Homo sapiens_hsa04020	0.47494923
81	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.47444669
82	Salivary secretion_Homo sapiens_hsa04970	0.47096365
83	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.46626864
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.46610425
85	RNA transport_Homo sapiens_hsa03013	0.46424474
86	Gap junction_Homo sapiens_hsa04540	0.46241318
87	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44184450
88	Arginine biosynthesis_Homo sapiens_hsa00220	0.43646351
89	Serotonergic synapse_Homo sapiens_hsa04726	0.40100398
90	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.39476627
91	Alcoholism_Homo sapiens_hsa05034	0.38900532
92	Asthma_Homo sapiens_hsa05310	0.38859930
93	mRNA surveillance pathway_Homo sapiens_hsa03015	0.38491279
94	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.36824609
95	Tyrosine metabolism_Homo sapiens_hsa00350	0.35462817
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35099491
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34883523
98	GABAergic synapse_Homo sapiens_hsa04727	0.34464066
99	Phagosome_Homo sapiens_hsa04145	0.32770448
100	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.32273911

KRT17P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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