ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	5.12931694
2	male meiosis (GO:0007140)	4.36059446
3	regulation of cilium movement (GO:0003352)	4.32367013
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.24240717
5	synapsis (GO:0007129)	4.16592124
6	indole-containing compound catabolic process (GO:0042436)	3.78319527
7	indolalkylamine catabolic process (GO:0046218)	3.78319527
8	tryptophan catabolic process (GO:0006569)	3.78319527
9	neural tube formation (GO:0001841)	3.73365612
10	DNA double-strand break processing (GO:0000729)	3.72457700
11	L-fucose catabolic process (GO:0042355)	3.70018744
12	fucose catabolic process (GO:0019317)	3.70018744
13	L-fucose metabolic process (GO:0042354)	3.70018744
14	platelet dense granule organization (GO:0060155)	3.69707684
15	detection of light stimulus involved in sensory perception (GO:0050962)	3.69422157
16	detection of light stimulus involved in visual perception (GO:0050908)	3.69422157
17	response to pheromone (GO:0019236)	3.68904449
18	replication fork processing (GO:0031297)	3.62070782
19	multicellular organism reproduction (GO:0032504)	3.59863708
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.50681131
21	epithelial cilium movement (GO:0003351)	3.42620641
22	coenzyme catabolic process (GO:0009109)	3.35716581
23	regulation of meiosis I (GO:0060631)	3.35674237
24	DNA methylation involved in gamete generation (GO:0043046)	3.34391856
25	male meiosis I (GO:0007141)	3.34221690
26	acrosome reaction (GO:0007340)	3.32686680
27	DNA deamination (GO:0045006)	3.31019792
28	behavioral response to nicotine (GO:0035095)	3.30820016
29	protein polyglutamylation (GO:0018095)	3.28618426
30	arginine catabolic process (GO:0006527)	3.28503845
31	cellular biogenic amine catabolic process (GO:0042402)	3.19298990
32	amine catabolic process (GO:0009310)	3.19298990
33	recombinational repair (GO:0000725)	3.14507324
34	behavioral response to ethanol (GO:0048149)	3.13444227
35	sperm motility (GO:0030317)	3.13209389
36	double-strand break repair via homologous recombination (GO:0000724)	3.09373918
37	cilium morphogenesis (GO:0060271)	3.07126407
38	protein complex biogenesis (GO:0070271)	3.06486791
39	indolalkylamine metabolic process (GO:0006586)	3.04714317
40	intraciliary transport (GO:0042073)	3.04600113
41	chromosome organization involved in meiosis (GO:0070192)	3.00067815
42	photoreceptor cell maintenance (GO:0045494)	2.98934539
43	meiotic nuclear division (GO:0007126)	2.96787943
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.93522461
45	glycosphingolipid biosynthetic process (GO:0006688)	2.91745839
46	ubiquinone biosynthetic process (GO:0006744)	2.91352170
47	protein-cofactor linkage (GO:0018065)	2.90132936
48	positive regulation of catecholamine secretion (GO:0033605)	2.89680296
49	resolution of meiotic recombination intermediates (GO:0000712)	2.88153321
50	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.87580941
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.86224693
52	attachment of spindle microtubules to kinetochore (GO:0008608)	2.85923127
53	meiosis I (GO:0007127)	2.81729619
54	cilium organization (GO:0044782)	2.78706847
55	tryptophan metabolic process (GO:0006568)	2.78079383
56	cilium or flagellum-dependent cell motility (GO:0001539)	2.77854753
57	cytochrome complex assembly (GO:0017004)	2.77542549
58	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.77211172
59	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.75471603
60	mannosylation (GO:0097502)	2.75251132
61	GPI anchor metabolic process (GO:0006505)	2.75091833
62	protein K11-linked deubiquitination (GO:0035871)	2.74388357
63	spermatid development (GO:0007286)	2.74383583
64	cilium assembly (GO:0042384)	2.73121511
65	adenosine metabolic process (GO:0046085)	2.71829697
66	sympathetic nervous system development (GO:0048485)	2.71152654
67	seminiferous tubule development (GO:0072520)	2.70528349
68	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.68404801
69	cell wall macromolecule catabolic process (GO:0016998)	2.66844225
70	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.66584394
71	ubiquinone metabolic process (GO:0006743)	2.66004827
72	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.64058904
73	NADH dehydrogenase complex assembly (GO:0010257)	2.64058904
74	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.64058904
75	regulation of DNA endoreduplication (GO:0032875)	2.63700382
76	cilium movement (GO:0003341)	2.63314242
77	histone exchange (GO:0043486)	2.62700255
78	respiratory chain complex IV assembly (GO:0008535)	2.62331987
79	centriole replication (GO:0007099)	2.62154898
80	histone H2A acetylation (GO:0043968)	2.61954337
81	DNA demethylation (GO:0080111)	2.61052320
82	lactate metabolic process (GO:0006089)	2.60210889
83	cornea development in camera-type eye (GO:0061303)	2.59300986
84	sperm-egg recognition (GO:0035036)	2.57489562
85	quinone biosynthetic process (GO:1901663)	2.56458209
86	gonadal mesoderm development (GO:0007506)	2.55548573
87	microtubule severing (GO:0051013)	2.52647200
88	protein localization to cilium (GO:0061512)	2.49992319
89	postreplication repair (GO:0006301)	2.48720317
90	axoneme assembly (GO:0035082)	2.48631407
91	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.48440475
92	retinal cone cell development (GO:0046549)	2.46810646
93	C-terminal protein lipidation (GO:0006501)	2.46764828
94	meiotic chromosome segregation (GO:0045132)	2.45630185
95	positive regulation of mitochondrial fission (GO:0090141)	2.45492129
96	heparin metabolic process (GO:0030202)	2.43683427
97	heparin biosynthetic process (GO:0030210)	2.43683427
98	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.43086069
99	regulation of protein glycosylation (GO:0060049)	2.42493386
100	cullin deneddylation (GO:0010388)	2.41996606

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.85418652
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.62709565
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.29467292
4	VDR_22108803_ChIP-Seq_LS180_Human	3.12213234
5	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.77010903
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.76512975
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.50470335
8	FUS_26573619_Chip-Seq_HEK293_Human	2.48239868
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.43151264
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.36876750
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.35179732
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.23994949
13	EWS_26573619_Chip-Seq_HEK293_Human	2.19502585
14	P300_19829295_ChIP-Seq_ESCs_Human	2.19032086
15	BCAT_22108803_ChIP-Seq_LS180_Human	2.17267259
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.14502619
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10232215
18	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.10152668
19	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.09630623
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.98378418
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.95531083
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.95531083
23	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.80611076
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77631215
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77583062
26	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.74022689
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71249257
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68940389
29	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.65302941
30	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65235797
31	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.64191300
32	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.60438816
33	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.59583393
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57943203
35	STAT3_23295773_ChIP-Seq_U87_Human	1.56990345
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55771420
37	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54843314
38	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.53820544
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.53343982
40	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49841712
41	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.49369801
42	AR_25329375_ChIP-Seq_VCAP_Human	1.46592395
43	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.46167033
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45881773
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45195372
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45195372
47	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44694611
48	TCF4_22108803_ChIP-Seq_LS180_Human	1.44292354
49	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.44064947
50	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.44006905
51	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.44006905
52	TCF4_23295773_ChIP-Seq_U87_Human	1.43098197
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.37800179
54	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37450256
55	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36984197
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.35466304
57	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.35302680
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35267752
59	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.34435006
60	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31218071
61	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.29389683
62	RUNX2_22187159_ChIP-Seq_PCA_Human	1.29195920
63	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.27608392
64	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.26413055
65	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26169449
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25727723
67	EZH2_22144423_ChIP-Seq_EOC_Human	1.21233940
68	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20460904
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19588264
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19284709
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18776811
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.16827420
73	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.16531279
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16436210
75	CDX2_22108803_ChIP-Seq_LS180_Human	1.15776437
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13783652
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13181717
78	MYC_18940864_ChIP-ChIP_HL60_Human	1.11500203
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11034265
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.09724098
81	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.09724098
82	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08706566
83	VDR_23849224_ChIP-Seq_CD4+_Human	1.08549778
84	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06746215
85	NCOR_22424771_ChIP-Seq_293T_Human	1.05149347
86	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04890859
87	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.04518875
88	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.04335474
89	AR_20517297_ChIP-Seq_VCAP_Human	1.03767825
90	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03490904
91	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.02802749
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.02790648
93	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.98914925
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97992530
95	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95256311
96	P300_18555785_Chip-Seq_ESCs_Mouse	0.95160107
97	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93597421
98	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.92561902
99	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.91665689
100	AR_21572438_ChIP-Seq_LNCaP_Human	0.91097032

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	4.66025942
2	MP0000372_irregular_coat_pigmentation	3.38984376
3	MP0008877_abnormal_DNA_methylation	3.02962271
4	MP0002837_dystrophic_cardiac_calcinosis	2.92267489
5	MP0001968_abnormal_touch/_nociception	2.66262019
6	MP0005174_abnormal_tail_pigmentation	2.50517473
7	MP0001984_abnormal_olfaction	2.43773173
8	MP0005410_abnormal_fertilization	2.43170963
9	MP0005551_abnormal_eye_electrophysiolog	2.32724207
10	MP0002736_abnormal_nociception_after	2.31632447
11	MP0005253_abnormal_eye_physiology	2.17719335
12	MP0000015_abnormal_ear_pigmentation	2.16396142
13	MP0003950_abnormal_plasma_membrane	1.97286175
14	MP0002234_abnormal_pharynx_morphology	1.95599889
15	MP0006072_abnormal_retinal_apoptosis	1.91927188
16	MP0005646_abnormal_pituitary_gland	1.90600777
17	MP0001529_abnormal_vocalization	1.84377186
18	MP0003880_abnormal_central_pattern	1.81949838
19	MP0002876_abnormal_thyroid_physiology	1.79736096
20	MP0006276_abnormal_autonomic_nervous	1.79685645
21	MP0005084_abnormal_gallbladder_morpholo	1.78324643
22	MP0003806_abnormal_nucleotide_metabolis	1.76730027
23	MP0002102_abnormal_ear_morphology	1.73711189
24	MP0003646_muscle_fatigue	1.70327006
25	MP0008058_abnormal_DNA_repair	1.68192141
26	MP0000749_muscle_degeneration	1.66359839
27	MP0005171_absent_coat_pigmentation	1.66235505
28	MP0003136_yellow_coat_color	1.65763175
29	MP0003195_calcinosis	1.65682732
30	MP0010094_abnormal_chromosome_stability	1.60756205
31	MP0005075_abnormal_melanosome_morpholog	1.60390816
32	MP0000427_abnormal_hair_cycle	1.59412157
33	MP0001501_abnormal_sleep_pattern	1.56766222
34	MP0002160_abnormal_reproductive_system	1.55999539
35	MP0001986_abnormal_taste_sensitivity	1.52849464
36	MP0003718_maternal_effect	1.49938270
37	MP0004084_abnormal_cardiac_muscle	1.49659429
38	MP0002095_abnormal_skin_pigmentation	1.46668106
39	MP0002638_abnormal_pupillary_reflex	1.45948578
40	MP0001929_abnormal_gametogenesis	1.45085380
41	MP0006054_spinal_hemorrhage	1.44954002
42	MP0002938_white_spotting	1.39115981
43	MP0009046_muscle_twitch	1.37919357
44	MP0003698_abnormal_male_reproductive	1.37290886
45	MP0002751_abnormal_autonomic_nervous	1.34797777
46	MP0009745_abnormal_behavioral_response	1.32905134
47	MP0002272_abnormal_nervous_system	1.31211801
48	MP0004215_abnormal_myocardial_fiber	1.30110313
49	MP0008057_abnormal_DNA_replication	1.28048490
50	MP0002653_abnormal_ependyma_morphology	1.24222438
51	MP0001764_abnormal_homeostasis	1.24198468
52	MP0001485_abnormal_pinna_reflex	1.24129914
53	MP0010386_abnormal_urinary_bladder	1.22655680
54	MP0004147_increased_porphyrin_level	1.21444204
55	MP0006036_abnormal_mitochondrial_physio	1.20967121
56	MP0005360_urolithiasis	1.20486165
57	MP0005670_abnormal_white_adipose	1.16182471
58	MP0001486_abnormal_startle_reflex	1.13016986
59	MP0004145_abnormal_muscle_electrophysio	1.11436522
60	MP0008872_abnormal_physiological_respon	1.11379572
61	MP0005645_abnormal_hypothalamus_physiol	1.10793420
62	MP0003045_fibrosis	1.05041000
63	MP0002138_abnormal_hepatobiliary_system	1.03146202
64	MP0000516_abnormal_urinary_system	1.01280620
65	MP0005367_renal/urinary_system_phenotyp	1.01280620
66	MP0005395_other_phenotype	1.01248920
67	MP0008789_abnormal_olfactory_epithelium	1.00262214
68	MP0002210_abnormal_sex_determination	0.99151392
69	MP0000631_abnormal_neuroendocrine_gland	0.98466047
70	MP0000653_abnormal_sex_gland	0.97793629
71	MP0005386_behavior/neurological_phenoty	0.96894959
72	MP0004924_abnormal_behavior	0.96894959
73	MP0005389_reproductive_system_phenotype	0.96608260
74	MP0009697_abnormal_copulation	0.95349773
75	MP0001324_abnormal_eye_pigmentation	0.94897749
76	MP0004043_abnormal_pH_regulation	0.90777178
77	MP0003787_abnormal_imprinting	0.90055470
78	MP0006035_abnormal_mitochondrial_morpho	0.89724844
79	MP0002282_abnormal_trachea_morphology	0.89442517
80	MP0001145_abnormal_male_reproductive	0.89138935
81	MP0005647_abnormal_sex_gland	0.88940968
82	MP0002168_other_aberrant_phenotype	0.88245542
83	MP0002734_abnormal_mechanical_nocicepti	0.87832974
84	MP0008775_abnormal_heart_ventricle	0.87331305
85	MP0008995_early_reproductive_senescence	0.86714203
86	MP0000538_abnormal_urinary_bladder	0.84834835
87	MP0001963_abnormal_hearing_physiology	0.81817166
88	MP0004085_abnormal_heartbeat	0.81409701
89	MP0005332_abnormal_amino_acid	0.79763200
90	MP0000230_abnormal_systemic_arterial	0.79363346
91	MP0005187_abnormal_penis_morphology	0.78747991
92	MP0003252_abnormal_bile_duct	0.78173158
93	MP0004270_analgesia	0.76025872
94	MP0006292_abnormal_olfactory_placode	0.75874246
95	MP0002090_abnormal_vision	0.75818965
96	MP0001119_abnormal_female_reproductive	0.75091467
97	MP0002067_abnormal_sensory_capabilities	0.75078021
98	MP0008875_abnormal_xenobiotic_pharmacok	0.74145249
99	MP0003633_abnormal_nervous_system	0.71929857
100	MP0003011_delayed_dark_adaptation	0.71402381

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.79313627
2	Volvulus (HP:0002580)	3.72768589
3	Pancreatic fibrosis (HP:0100732)	3.53519054
4	True hermaphroditism (HP:0010459)	3.46734663
5	Inability to walk (HP:0002540)	3.22434060
6	Molar tooth sign on MRI (HP:0002419)	3.14140210
7	Abnormality of midbrain morphology (HP:0002418)	3.14140210
8	Renal cortical cysts (HP:0000803)	3.03011932
9	Abnormality of the renal cortex (HP:0011035)	3.02597706
10	Pancreatic islet-cell hyperplasia (HP:0004510)	2.96935930
11	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.94255329
12	Absent/shortened dynein arms (HP:0200106)	2.85822252
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.85822252
14	Fair hair (HP:0002286)	2.85442643
15	Abnormality of macular pigmentation (HP:0008002)	2.84879211
16	Progressive inability to walk (HP:0002505)	2.84835788
17	Type II lissencephaly (HP:0007260)	2.82553952
18	Intestinal atresia (HP:0011100)	2.80628919
19	Hyperventilation (HP:0002883)	2.71614561
20	Chromsome breakage (HP:0040012)	2.68923727
21	Tubulointerstitial nephritis (HP:0001970)	2.62357224
22	Abolished electroretinogram (ERG) (HP:0000550)	2.61982357
23	Abnormality of the ileum (HP:0001549)	2.61612343
24	Absent speech (HP:0001344)	2.61209664
25	Nephronophthisis (HP:0000090)	2.59181438
26	Hypoproteinemia (HP:0003075)	2.54348764
27	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.52035754
28	Increased corneal curvature (HP:0100692)	2.49676620
29	Keratoconus (HP:0000563)	2.49676620
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.46071946
31	Abnormality of the renal medulla (HP:0100957)	2.43139181
32	Gaze-evoked nystagmus (HP:0000640)	2.36795553
33	Attenuation of retinal blood vessels (HP:0007843)	2.36187670
34	Type 2 muscle fiber atrophy (HP:0003554)	2.32998854
35	Retinal dysplasia (HP:0007973)	2.32793079
36	Medial flaring of the eyebrow (HP:0010747)	2.31234668
37	Thyroid-stimulating hormone excess (HP:0002925)	2.31076727
38	Meckel diverticulum (HP:0002245)	2.30183812
39	Severe visual impairment (HP:0001141)	2.29584970
40	Progressive macrocephaly (HP:0004481)	2.26592830
41	Generalized hypopigmentation of hair (HP:0011358)	2.25601484
42	Male pseudohermaphroditism (HP:0000037)	2.23903700
43	Cystic liver disease (HP:0006706)	2.22487528
44	Methylmalonic acidemia (HP:0002912)	2.22469220
45	Acute necrotizing encephalopathy (HP:0006965)	2.21680728
46	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21277791
47	Decreased central vision (HP:0007663)	2.19558221
48	Large for gestational age (HP:0001520)	2.18228207
49	Pendular nystagmus (HP:0012043)	2.18085261
50	Cerebellar dysplasia (HP:0007033)	2.15843750
51	Abnormal ciliary motility (HP:0012262)	2.15388424
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.13197545
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.13197545
54	Widely spaced teeth (HP:0000687)	2.11428548
55	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.10813527
56	Chronic hepatic failure (HP:0100626)	2.09086159
57	Abnormality of chromosome stability (HP:0003220)	2.06602356
58	Mitochondrial inheritance (HP:0001427)	2.05137955
59	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.02912183
60	Abnormal protein N-linked glycosylation (HP:0012347)	2.02912183
61	Abnormal protein glycosylation (HP:0012346)	2.02912183
62	Abnormal glycosylation (HP:0012345)	2.02912183
63	Clubbing of toes (HP:0100760)	2.02579151
64	Congenital hepatic fibrosis (HP:0002612)	2.00607904
65	Tubular atrophy (HP:0000092)	2.00358716
66	Congenital stationary night blindness (HP:0007642)	1.99252712
67	Febrile seizures (HP:0002373)	1.98442988
68	Acute encephalopathy (HP:0006846)	1.96460493
69	Postaxial foot polydactyly (HP:0001830)	1.96358341
70	Facial diplegia (HP:0001349)	1.95314728
71	Increased CSF lactate (HP:0002490)	1.94619083
72	Methylmalonic aciduria (HP:0012120)	1.94403300
73	Albinism (HP:0001022)	1.93964834
74	Abnormal mitochondria in muscle tissue (HP:0008316)	1.93956947
75	Poor head control (HP:0002421)	1.93205707
76	Hyperglycinemia (HP:0002154)	1.92401895
77	Constricted visual fields (HP:0001133)	1.92301049
78	Focal motor seizures (HP:0011153)	1.89807793
79	Astigmatism (HP:0000483)	1.88350406
80	Small hand (HP:0200055)	1.87603457
81	Clumsiness (HP:0002312)	1.87502637
82	Anencephaly (HP:0002323)	1.85461802
83	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84913210
84	Abnormality of endocrine pancreas physiology (HP:0012093)	1.84663077
85	Abnormality of the pancreatic islet cells (HP:0006476)	1.84663077
86	Abnormality of the labia minora (HP:0012880)	1.83632864
87	Sclerocornea (HP:0000647)	1.83195645
88	Type I transferrin isoform profile (HP:0003642)	1.82730505
89	Sloping forehead (HP:0000340)	1.82603313
90	Postaxial hand polydactyly (HP:0001162)	1.80303727
91	Broad-based gait (HP:0002136)	1.79199164
92	Lissencephaly (HP:0001339)	1.78324167
93	Atonic seizures (HP:0010819)	1.76724983
94	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.75859949
95	Hypothermia (HP:0002045)	1.75637596
96	Occipital encephalocele (HP:0002085)	1.75340778
97	Tubulointerstitial abnormality (HP:0001969)	1.72219322
98	Photophobia (HP:0000613)	1.71264094
99	Congenital primary aphakia (HP:0007707)	1.70626247
100	Abnormality of the preputium (HP:0100587)	1.70302598

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.70153418
2	PINK1	4.92134743
3	MAP4K2	3.08411612
4	WNK3	2.91938286
5	INSRR	2.44134999
6	MUSK	2.33758210
7	BMPR1B	2.28776666
8	ADRBK2	2.27454733
9	MAPK13	2.23257625
10	NEK1	2.11285348
11	NUAK1	2.05665823
12	ZAK	2.01241416
13	BCR	1.99614572
14	TRIM28	1.84692732
15	EIF2AK3	1.70217964
16	MARK3	1.55146098
17	WEE1	1.50506157
18	PAK3	1.50461217
19	PLK2	1.41769546
20	GRK1	1.40740002
21	TXK	1.38313983
22	CASK	1.36969815
23	OXSR1	1.36921544
24	CCNB1	1.27967869
25	BRSK2	1.24863178
26	OBSCN	1.21725349
27	PLK4	1.20372848
28	CSNK1G2	1.20354073
29	PRKD3	1.19714200
30	CSNK1G3	1.19467888
31	FER	1.19164105
32	BCKDK	1.17866705
33	CSNK1G1	1.10884453
34	ERBB3	1.09789238
35	ACVR1B	1.08284862
36	CSNK1A1L	1.06360932
37	NEK2	1.04609508
38	STK3	1.04347095
39	EPHA4	0.94827473
40	EPHA3	0.93804103
41	STK39	0.93030594
42	PLK3	0.92156116
43	MARK1	0.87100209
44	PTK2B	0.85399139
45	FGFR2	0.83868039
46	PRKCE	0.82911601
47	MKNK2	0.81199587
48	MST4	0.80015568
49	TLK1	0.78898574
50	PLK1	0.77772825
51	PKN1	0.75040367
52	VRK1	0.73397873
53	WNK4	0.72033406
54	RPS6KA5	0.68649216
55	STK38L	0.68529044
56	BUB1	0.67436670
57	DYRK2	0.67335451
58	MAP3K4	0.64776949
59	PDK2	0.63641577
60	CDK3	0.63615689
61	LATS1	0.61446799
62	TIE1	0.59877330
63	TGFBR1	0.56808413
64	CLK1	0.55119495
65	TAOK3	0.53063240
66	EIF2AK1	0.52602119
67	ADRBK1	0.52242700
68	ATM	0.51439737
69	PBK	0.50649361
70	SRPK1	0.49784001
71	MAPKAPK3	0.48840343
72	CAMK2A	0.48443491
73	CSNK1A1	0.48358818
74	ATR	0.47993536
75	KDR	0.46569735
76	ROCK1	0.46353151
77	PRKCG	0.45714679
78	MINK1	0.45145751
79	VRK2	0.44304447
80	TNK2	0.40078621
81	MET	0.40067303
82	PIK3CA	0.39922076
83	MAP2K7	0.37951821
84	MYLK	0.34901413
85	IGF1R	0.33226440
86	RPS6KA4	0.33174986
87	CAMK2D	0.33125871
88	PRKCQ	0.33081981
89	NTRK3	0.32605159
90	PRKCI	0.31915298
91	NLK	0.31797509
92	CDK8	0.30725914
93	ABL1	0.30639892
94	CSNK1D	0.30179427
95	PRKACA	0.30042902
96	EIF2AK2	0.28729526
97	PRKG1	0.28221704
98	AURKB	0.28083102
99	PIK3CG	0.28079080
100	GRK5	0.28017024

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.13763186
2	Homologous recombination_Homo sapiens_hsa03440	3.13164566
3	Fanconi anemia pathway_Homo sapiens_hsa03460	2.94101660
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.82880450
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.69996847
6	Propanoate metabolism_Homo sapiens_hsa00640	2.59011793
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.58681769
8	Butanoate metabolism_Homo sapiens_hsa00650	2.48067981
9	Phototransduction_Homo sapiens_hsa04744	2.27262186
10	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.15796010
11	Non-homologous end-joining_Homo sapiens_hsa03450	2.00541966
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.97443150
13	Protein export_Homo sapiens_hsa03060	1.90334764
14	Basal transcription factors_Homo sapiens_hsa03022	1.77397043
15	Proteasome_Homo sapiens_hsa03050	1.70521683
16	Olfactory transduction_Homo sapiens_hsa04740	1.66793019
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.65365108
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.55333904
19	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.54968219
20	Regulation of autophagy_Homo sapiens_hsa04140	1.54821167
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.49989463
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45897436
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.42533188
24	RNA polymerase_Homo sapiens_hsa03020	1.41419620
25	RNA degradation_Homo sapiens_hsa03018	1.39544164
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.38432654
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.36979017
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.33606765
29	Mismatch repair_Homo sapiens_hsa03430	1.27804525
30	Taste transduction_Homo sapiens_hsa04742	1.22827841
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22135205
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21354621
33	Oxidative phosphorylation_Homo sapiens_hsa00190	1.20107525
34	Peroxisome_Homo sapiens_hsa04146	1.18152018
35	Selenocompound metabolism_Homo sapiens_hsa00450	1.17542808
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.12313190
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.11570207
38	Parkinsons disease_Homo sapiens_hsa05012	1.09836511
39	Ether lipid metabolism_Homo sapiens_hsa00565	1.09747121
40	Purine metabolism_Homo sapiens_hsa00230	1.08159528
41	Caffeine metabolism_Homo sapiens_hsa00232	1.07896999
42	Nicotine addiction_Homo sapiens_hsa05033	1.05461885
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03378790
44	Retinol metabolism_Homo sapiens_hsa00830	1.03194422
45	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.00326038
46	ABC transporters_Homo sapiens_hsa02010	1.00307275
47	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00200099
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00128885
49	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99509046
50	Circadian rhythm_Homo sapiens_hsa04710	0.90737083
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90146758
52	Glutathione metabolism_Homo sapiens_hsa00480	0.89212521
53	Oocyte meiosis_Homo sapiens_hsa04114	0.83751970
54	Fatty acid degradation_Homo sapiens_hsa00071	0.83002828
55	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80287846
56	Fatty acid elongation_Homo sapiens_hsa00062	0.76384434
57	Base excision repair_Homo sapiens_hsa03410	0.76153011
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.76015370
59	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.74555078
60	Metabolic pathways_Homo sapiens_hsa01100	0.73496516
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.72515700
62	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71991459
63	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.71931264
64	DNA replication_Homo sapiens_hsa03030	0.68239364
65	Circadian entrainment_Homo sapiens_hsa04713	0.68209307
66	Huntingtons disease_Homo sapiens_hsa05016	0.66024089
67	Nucleotide excision repair_Homo sapiens_hsa03420	0.65107173
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64483469
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.63470911
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63143131
71	Morphine addiction_Homo sapiens_hsa05032	0.61634647
72	Salivary secretion_Homo sapiens_hsa04970	0.60586590
73	GABAergic synapse_Homo sapiens_hsa04727	0.57736133
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56965312
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55547432
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55099590
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49930316
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.49470645
79	Sulfur metabolism_Homo sapiens_hsa00920	0.48560497
80	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48109038
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.47998563
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47884842
83	Primary immunodeficiency_Homo sapiens_hsa05340	0.47501873
84	Alzheimers disease_Homo sapiens_hsa05010	0.47244468
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.47234370
86	One carbon pool by folate_Homo sapiens_hsa00670	0.46089548
87	RNA transport_Homo sapiens_hsa03013	0.45844643
88	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44843306
89	Histidine metabolism_Homo sapiens_hsa00340	0.44076819
90	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41314575
91	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.40724437
92	p53 signaling pathway_Homo sapiens_hsa04115	0.40344430
93	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.39938069
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.36929008
95	Glutamatergic synapse_Homo sapiens_hsa04724	0.36493040
96	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36321940
97	Graft-versus-host disease_Homo sapiens_hsa05332	0.36055476
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.33963555
99	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.33762277
100	Renin secretion_Homo sapiens_hsa04924	0.33225900

KRT17P7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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