ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	9.43952500
2	drug catabolic process (GO:0042737)	9.08159052
3	negative regulation of fibrinolysis (GO:0051918)	7.99210763
4	regulation of fibrinolysis (GO:0051917)	7.89905214
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.38978989
6	L-phenylalanine catabolic process (GO:0006559)	7.38978989
7	epoxygenase P450 pathway (GO:0019373)	7.22650191
8	omega-hydroxylase P450 pathway (GO:0097267)	7.20007679
9	glyoxylate metabolic process (GO:0046487)	7.08791755
10	complement activation, alternative pathway (GO:0006957)	7.01545016
11	regulation of protein activation cascade (GO:2000257)	6.95297236
12	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.88424235
13	L-phenylalanine metabolic process (GO:0006558)	6.88424235
14	urea metabolic process (GO:0019627)	6.85880217
15	fibrinolysis (GO:0042730)	6.51206873
16	regulation of complement activation (GO:0030449)	6.48154547
17	peptidyl-glutamic acid carboxylation (GO:0017187)	6.38106529
18	protein carboxylation (GO:0018214)	6.38106529
19	nitrogen cycle metabolic process (GO:0071941)	6.33035727
20	cellular glucuronidation (GO:0052695)	6.11485819
21	oxidative demethylation (GO:0070989)	5.93977084
22	bile acid biosynthetic process (GO:0006699)	5.87097617
23	uronic acid metabolic process (GO:0006063)	5.76098535
24	glucuronate metabolic process (GO:0019585)	5.76098535
25	urea cycle (GO:0000050)	5.72319446
26	phenylpropanoid metabolic process (GO:0009698)	5.67156763
27	blood coagulation, intrinsic pathway (GO:0007597)	5.66981244
28	drug metabolic process (GO:0017144)	5.57425203
29	ethanol oxidation (GO:0006069)	5.47206465
30	bile acid metabolic process (GO:0008206)	5.20260788
31	regulation of triglyceride catabolic process (GO:0010896)	5.16326319
32	aromatic amino acid family catabolic process (GO:0009074)	5.11415368
33	negative regulation of cholesterol transport (GO:0032375)	5.01513811
34	negative regulation of sterol transport (GO:0032372)	5.01513811
35	serine family amino acid catabolic process (GO:0009071)	5.00548427
36	alkaloid metabolic process (GO:0009820)	4.83674278
37	negative regulation of blood coagulation (GO:0030195)	4.69250443
38	negative regulation of hemostasis (GO:1900047)	4.69250443
39	bile acid and bile salt transport (GO:0015721)	4.63597514
40	regulation of plasminogen activation (GO:0010755)	4.55205773
41	S-adenosylmethionine metabolic process (GO:0046500)	4.54754590
42	glycine metabolic process (GO:0006544)	4.49885663
43	tyrosine metabolic process (GO:0006570)	4.47438161
44	regulation of humoral immune response (GO:0002920)	4.44790892
45	acylglycerol homeostasis (GO:0055090)	4.40826586
46	triglyceride homeostasis (GO:0070328)	4.40826586
47	protein activation cascade (GO:0072376)	4.40637437
48	amino-acid betaine metabolic process (GO:0006577)	4.39753658
49	ethanol metabolic process (GO:0006067)	4.35264694
50	acute-phase response (GO:0006953)	4.26451703
51	positive regulation of hemostasis (GO:1900048)	4.24563293
52	positive regulation of blood coagulation (GO:0030194)	4.24563293
53	negative regulation of coagulation (GO:0050819)	4.22272723
54	negative regulation of protein activation cascade (GO:2000258)	4.18896807
55	phospholipid efflux (GO:0033700)	4.18623186
56	negative regulation of wound healing (GO:0061045)	4.15370060
57	daunorubicin metabolic process (GO:0044597)	4.07424467
58	polyketide metabolic process (GO:0030638)	4.07424467
59	doxorubicin metabolic process (GO:0044598)	4.07424467
60	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.06476185
61	complement activation (GO:0006956)	4.00017302
62	positive regulation of coagulation (GO:0050820)	3.97077790
63	complement activation, classical pathway (GO:0006958)	3.93097548
64	hormone catabolic process (GO:0042447)	3.89345872
65	positive regulation of lipoprotein lipase activity (GO:0051006)	3.87528342
66	positive regulation of triglyceride lipase activity (GO:0061365)	3.87528342
67	arginine metabolic process (GO:0006525)	3.84985060
68	steroid catabolic process (GO:0006706)	3.82397321
69	cytolysis (GO:0019835)	3.76038277
70	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	3.74558417
71	fat-soluble vitamin biosynthetic process (GO:0042362)	3.68625492
72	very-low-density lipoprotein particle assembly (GO:0034379)	3.67565605
73	negative regulation of lipase activity (GO:0060192)	3.66502952
74	cholesterol efflux (GO:0033344)	3.64620734
75	macromolecular complex remodeling (GO:0034367)	3.63959417
76	plasma lipoprotein particle remodeling (GO:0034369)	3.63959417
77	protein-lipid complex remodeling (GO:0034368)	3.63959417
78	high-density lipoprotein particle remodeling (GO:0034375)	3.60924174
79	aminoglycoside antibiotic metabolic process (GO:0030647)	3.59738217
80	flavonoid metabolic process (GO:0009812)	3.59248392
81	aromatic amino acid family metabolic process (GO:0009072)	3.59180206
82	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.53432992
83	serine family amino acid metabolic process (GO:0009069)	3.52416397
84	sodium-independent organic anion transport (GO:0043252)	3.51159505
85	heme transport (GO:0015886)	3.50896939
86	response to mercury ion (GO:0046689)	3.50649018
87	regulation of cholesterol esterification (GO:0010872)	3.50592683
88	negative regulation of complement activation (GO:0045916)	3.49206764
89	imidazole-containing compound metabolic process (GO:0052803)	3.47932391
90	disruption of cells of other organism involved in symbiotic interaction (GO:0051818)	3.45734545
91	killing of cells in other organism involved in symbiotic interaction (GO:0051883)	3.45734545
92	intestinal cholesterol absorption (GO:0030299)	3.42787117
93	opsonization (GO:0008228)	3.40316415
94	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.38240961
95	xenobiotic metabolic process (GO:0006805)	3.29197655
96	alpha-amino acid catabolic process (GO:1901606)	3.28281855
97	acute inflammatory response (GO:0002526)	3.27834986
98	regulation of lipoprotein particle clearance (GO:0010984)	3.25879784
99	primary alcohol catabolic process (GO:0034310)	3.25801811
100	phospholipid homeostasis (GO:0055091)	3.25733010

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	8.84078770
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.90913305
3	EGR1_23403033_ChIP-Seq_LIVER_Mouse	5.90644118
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	5.24344759
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.75520566
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.33234435
7	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.05100073
8	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.92013307
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.51926949
10	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.45944938
11	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.26061147
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.95713717
13	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.31663554
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.13710596
15	RUNX_20019798_ChIP-Seq_JUKART_Human	2.10161477
16	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.06404415
17	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.02774327
18	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.95714992
19	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.82138283
20	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.75574911
21	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70642163
22	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.59151497
23	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.58851242
24	SCL_19346495_ChIP-Seq_HPC-7_Human	1.56911678
25	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.55299829
26	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.51552808
27	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.36703589
28	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.34523829
29	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.34061971
30	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.33702400
31	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.33015012
32	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.26977445
33	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.25414483
34	MYB_26560356_Chip-Seq_TH2_Human	1.24158359
35	MYB_26560356_Chip-Seq_TH1_Human	1.22679954
36	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.18785279
37	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.17752167
38	BRD4_27068464_Chip-Seq_AML-cells_Mouse	1.17671697
39	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.15727124
40	MAF_26560356_Chip-Seq_TH1_Human	1.14151810
41	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.09795253
42	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.08982571
43	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06742688
44	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.05297793
45	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.03944025
46	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.99596054
47	UTX_26944678_Chip-Seq_JUKART_Human	0.96786913
48	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.96429221
49	RUNX1_22412390_ChIP-Seq_EML_Mouse	0.95007457
50	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.94599317
51	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.93818560
52	GATA1_19941826_ChIP-Seq_K562_Human	0.93075702
53	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.92314104
54	GATA3_26560356_Chip-Seq_TH2_Human	0.91862021
55	TCF7_22412390_ChIP-Seq_EML_Mouse	0.91423645
56	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.89951342
57	SPI1_23127762_ChIP-Seq_K562_Human	0.89746657
58	CEBPB_22108803_ChIP-Seq_LS180_Human	0.89701313
59	VDR_21846776_ChIP-Seq_THP-1_Human	0.87576894
60	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.86182473
61	VDR_24763502_ChIP-Seq_THP-1_Human	0.85852397
62	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.84689852
63	GATA2_22383799_ChIP-Seq_G1ME_Mouse	0.84442179
64	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.84074431
65	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83562622
66	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.82474272
67	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.82155300
68	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.81959285
69	PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.81727057
70	KDM2B_26808549_Chip-Seq_HPB-ALL_Human	0.81189491
71	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.80288059
72	SPI1_20517297_ChIP-Seq_HL60_Human	0.78061360
73	IRF1_19129219_ChIP-ChIP_H3396_Human	0.77845956
74	GATA2_19941826_ChIP-Seq_K562_Human	0.77764952
75	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.77397018
76	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.76514265
77	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	0.76336290
78	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.76158666
79	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.75500742
80	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.75479976
81	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	0.75184095
82	GATA1_22025678_ChIP-Seq_K562_Human	0.75051203
83	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.74526141
84	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.74374255
85	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.74353821
86	MAF_26560356_Chip-Seq_TH2_Human	0.74274946
87	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.73670204
88	SPI1_23547873_ChIP-Seq_NB4_Human	0.72929097
89	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.72503851
90	MYC_22102868_ChIP-Seq_BL_Human	0.72189424
91	CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.72140179
92	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.71974434
93	P300_27268052_Chip-Seq_Bcells_Human	0.71936052
94	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.71221077
95	GATA6_25053715_ChIP-Seq_YYC3_Human	0.68875804
96	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.67776612
97	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.65548579
98	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.64988891
99	CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse	0.64977111
100	GATA4_25053715_ChIP-Seq_YYC3_Human	0.63789669

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.96830275
2	MP0005360_urolithiasis	6.29552976
3	MP0005085_abnormal_gallbladder_physiolo	5.71431266
4	MP0005365_abnormal_bile_salt	5.51518321
5	MP0008875_abnormal_xenobiotic_pharmacok	4.83893100
6	MP0003195_calcinosis	4.30696060
7	MP0003252_abnormal_bile_duct	3.89045307
8	MP0002138_abnormal_hepatobiliary_system	3.85683801
9	MP0003868_abnormal_feces_composition	3.13201334
10	MP0001666_abnormal_nutrient_absorption	3.02414968
11	MP0009697_abnormal_copulation	2.58037656
12	MP0010329_abnormal_lipoprotein_level	2.42800467
13	MP0003191_abnormal_cellular_cholesterol	2.24625138
14	MP0003806_abnormal_nucleotide_metabolis	2.24005677
15	MP0009840_abnormal_foam_cell	2.18626478
16	MP0005332_abnormal_amino_acid	1.91538708
17	MP0005451_abnormal_body_composition	1.84049912
18	MP0000609_abnormal_liver_physiology	1.82216440
19	MP0002118_abnormal_lipid_homeostasis	1.53429622
20	MP0003763_abnormal_thymus_physiology	1.52942955
21	MP0001764_abnormal_homeostasis	1.46731644
22	MP0005464_abnormal_platelet_physiology	1.38049586
23	MP0003656_abnormal_erythrocyte_physiolo	1.26889316
24	MP0001915_intracranial_hemorrhage	1.25894850
25	MP0008260_abnormal_autophagy	1.25653528
26	MP0003436_decreased_susceptibility_to	1.23415990
27	MP0002876_abnormal_thyroid_physiology	1.21077655
28	MP0005319_abnormal_enzyme/_coenzyme	1.17918168
29	MP0005408_hypopigmentation	1.17392118
30	MP0008469_abnormal_protein_level	1.12493208
31	MP0000598_abnormal_liver_morphology	1.12086424
32	MP0000604_amyloidosis	1.09214444
33	MP0001800_abnormal_humoral_immune	1.07489248
34	MP0002132_abnormal_respiratory_system	1.05208029
35	MP0009785_altered_susceptibility_to	1.03738125
36	MP0009763_increased_sensitivity_to	1.01943977
37	MP0003690_abnormal_glial_cell	0.99595040
38	MP0002419_abnormal_innate_immunity	0.99117505
39	MP0005584_abnormal_enzyme/coenzyme_acti	0.97913642
40	MP0005025_abnormal_response_to	0.96108491
41	MP0004883_abnormal_blood_vessel	0.95626303
42	MP0009764_decreased_sensitivity_to	0.95246509
43	MP0009643_abnormal_urine_homeostasis	0.95243770
44	MP0005376_homeostasis/metabolism_phenot	0.93286123
45	MP0001851_eye_inflammation	0.92583571
46	MP0009333_abnormal_splenocyte_physiolog	0.92209559
47	MP0004019_abnormal_vitamin_homeostasis	0.91345983
48	MP0001835_abnormal_antigen_presentation	0.90470151
49	MP0009642_abnormal_blood_homeostasis	0.82933336
50	MP0000685_abnormal_immune_system	0.81853890
51	MP0003300_gastrointestinal_ulcer	0.80416480
52	MP0001845_abnormal_inflammatory_respons	0.77018918
53	MP0004130_abnormal_muscle_cell	0.75444550
54	MP0003303_peritoneal_inflammation	0.73952002
55	MP0002723_abnormal_immune_serum	0.73879037
56	MP0000689_abnormal_spleen_morphology	0.73588456
57	MP0003186_abnormal_redox_activity	0.73118431
58	MP0005000_abnormal_immune_tolerance	0.72843954
59	MP0003724_increased_susceptibility_to	0.72392018
60	MP0005164_abnormal_response_to	0.71062126
61	MP0005397_hematopoietic_system_phenotyp	0.70715238
62	MP0001545_abnormal_hematopoietic_system	0.70715238
63	MP0008874_decreased_physiological_sensi	0.64817181
64	MP0010368_abnormal_lymphatic_system	0.64265050
65	MP0005636_abnormal_mineral_homeostasis	0.64193623
66	MP0006082_CNS_inflammation	0.63252018
67	MP0000858_altered_metastatic_potential	0.62521475
68	MP0005058_abnormal_lysosome_morphology	0.62427605
69	MP0002420_abnormal_adaptive_immunity	0.60652457
70	MP0005395_other_phenotype	0.60196764
71	MP0001819_abnormal_immune_cell	0.60061231
72	MP0003638_abnormal_response/metabolism_	0.59904612
73	MP0002452_abnormal_antigen_presenting	0.59899267
74	MP0003329_amyloid_beta_deposits	0.59548416
75	MP0002722_abnormal_immune_system	0.59463398
76	MP0005671_abnormal_response_to	0.59290193
77	MP0001661_extended_life_span	0.58963616
78	MP0005266_abnormal_metabolism	0.58869008
79	MP0002971_abnormal_brown_adipose	0.58393234
80	MP0009053_abnormal_anal_canal	0.57980441
81	MP0000249_abnormal_blood_vessel	0.57855435
82	MP0002398_abnormal_bone_marrow	0.56441311
83	MP0000716_abnormal_immune_system	0.56276554
84	MP0010155_abnormal_intestine_physiology	0.56191856
85	MP0005535_abnormal_body_temperature	0.54469792
86	MP0002405_respiratory_system_inflammati	0.54422555
87	MP0002168_other_aberrant_phenotype	0.54360724
88	MP0003866_abnormal_defecation	0.53130480
89	MP0005023_abnormal_wound_healing	0.51906046
90	MP0009765_abnormal_xenobiotic_induced	0.50278700
91	MP0005387_immune_system_phenotype	0.50254459
92	MP0001790_abnormal_immune_system	0.50254459
93	MP0002078_abnormal_glucose_homeostasis	0.49946858
94	MP0002928_abnormal_bile_duct	0.48321768
95	MP0002933_joint_inflammation	0.48229797
96	MP0004947_skin_inflammation	0.47309630
97	MP0005187_abnormal_penis_morphology	0.46968174
98	MP0002332_abnormal_exercise_endurance	0.46051929
99	MP0000465_gastrointestinal_hemorrhage	0.45940048
100	MP0006036_abnormal_mitochondrial_physio	0.45789986

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	9.35777275
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	9.08650559
3	Prolonged partial thromboplastin time (HP:0003645)	7.81249010
4	Hypobetalipoproteinemia (HP:0003563)	7.76145937
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.24798344
6	Complement deficiency (HP:0004431)	7.23044799
7	Joint hemorrhage (HP:0005261)	5.96712664
8	Conjugated hyperbilirubinemia (HP:0002908)	5.96212012
9	Abnormality of complement system (HP:0005339)	5.88157754
10	Systemic lupus erythematosus (HP:0002725)	5.32486955
11	Hyperlipoproteinemia (HP:0010980)	5.19402551
12	Intrahepatic cholestasis (HP:0001406)	4.68762454
13	Abnormality of the common coagulation pathway (HP:0010990)	4.62721187
14	Recurrent gram-negative bacterial infections (HP:0005420)	4.44949050
15	Abnormality of pyrimidine metabolism (HP:0004353)	4.31002921
16	Hypolipoproteinemia (HP:0010981)	4.25749262
17	Xanthomatosis (HP:0000991)	4.20014014
18	Gingival bleeding (HP:0000225)	4.00835378
19	Spontaneous abortion (HP:0005268)	3.99664952
20	Glomerulonephritis (HP:0000099)	3.90114868
21	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.70173335
22	Fat malabsorption (HP:0002630)	3.39412317
23	Nephritis (HP:0000123)	3.24840977
24	Abnormality of the intrinsic pathway (HP:0010989)	3.11387998
25	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.10900008
26	Menorrhagia (HP:0000132)	3.04803725
27	Hyperammonemia (HP:0001987)	2.96129812
28	Pulmonary embolism (HP:0002204)	2.92784088
29	Hepatocellular carcinoma (HP:0001402)	2.89801379
30	Hemorrhage of the eye (HP:0011885)	2.78189576
31	Thrombophlebitis (HP:0004418)	2.77746112
32	Abnormality of methionine metabolism (HP:0010901)	2.73588784
33	Hyperglycinemia (HP:0002154)	2.73351925
34	Rickets (HP:0002748)	2.73237618
35	Steatorrhea (HP:0002570)	2.69134515
36	Epistaxis (HP:0000421)	2.64496400
37	Mitral stenosis (HP:0001718)	2.63355963
38	Hypoalphalipoproteinemia (HP:0003233)	2.62605724
39	Hypochromic microcytic anemia (HP:0004840)	2.60223431
40	Purpura (HP:0000979)	2.60170041
41	Generalized aminoaciduria (HP:0002909)	2.60009943
42	Osteomalacia (HP:0002749)	2.56982325
43	Hypercholesterolemia (HP:0003124)	2.46499242
44	Vascular calcification (HP:0004934)	2.45823988
45	Abnormality of nucleobase metabolism (HP:0010932)	2.45070480
46	Joint swelling (HP:0001386)	2.45062232
47	Hyperbilirubinemia (HP:0002904)	2.31578491
48	Recurrent abscess formation (HP:0002722)	2.30135879
49	Eczematoid dermatitis (HP:0000976)	2.29695798
50	Neonatal hypoglycemia (HP:0001998)	2.26872820
51	Increased mean platelet volume (HP:0011877)	2.24976228
52	Poikilocytosis (HP:0004447)	2.24713730
53	Abnormal platelet volume (HP:0011876)	2.24699547
54	T lymphocytopenia (HP:0005403)	2.21818048
55	Abnormality of serine family amino acid metabolism (HP:0010894)	2.21460427
56	Abnormality of glycine metabolism (HP:0010895)	2.21460427
57	Increased serum ferritin (HP:0003281)	2.21040334
58	Gangrene (HP:0100758)	2.19831569
59	Myocardial infarction (HP:0001658)	2.17865984
60	Hypochromic anemia (HP:0001931)	2.17787525
61	Abnormality of serum amino acid levels (HP:0003112)	2.15852815
62	Abnormality of iron homeostasis (HP:0011031)	2.12625235
63	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.11245873
64	Reduced antithrombin III activity (HP:0001976)	2.10794876
65	Cardiovascular calcification (HP:0011915)	2.09027097
66	Hyperphosphaturia (HP:0003109)	2.06721056
67	Arthropathy (HP:0003040)	2.06383925
68	Cholelithiasis (HP:0001081)	2.06050065
69	Hyperglycinuria (HP:0003108)	2.05012205
70	Cholecystitis (HP:0001082)	2.03031266
71	Abnormal gallbladder physiology (HP:0012438)	2.03031266
72	Abnormality of T cell number (HP:0011839)	2.01609606
73	Periodontitis (HP:0000704)	2.01571457
74	Myositis (HP:0100614)	1.98534584
75	Elevated alkaline phosphatase (HP:0003155)	1.93498662
76	Prolonged bleeding time (HP:0003010)	1.92897586
77	Fair hair (HP:0002286)	1.91871182
78	Abnormality of transition element cation homeostasis (HP:0011030)	1.91159070
79	Abnormal gallbladder morphology (HP:0012437)	1.89401379
80	Acanthocytosis (HP:0001927)	1.87080852
81	Metabolic acidosis (HP:0001942)	1.86538157
82	Epidermoid cyst (HP:0200040)	1.85575604
83	Gingivitis (HP:0000230)	1.83957894
84	Abnormal enzyme/coenzyme activity (HP:0012379)	1.81100746
85	Stomatitis (HP:0010280)	1.81042957
86	Acute hepatic failure (HP:0006554)	1.79151260
87	Abnormality of urine glucose concentration (HP:0011016)	1.78306999
88	Glycosuria (HP:0003076)	1.78306999
89	Hypophosphatemic rickets (HP:0004912)	1.78177429
90	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.77516323
91	Optic neuritis (HP:0100653)	1.77048122
92	Retrobulbar optic neuritis (HP:0100654)	1.77048122
93	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.76232287
94	Gastrointestinal infarctions (HP:0005244)	1.76179779
95	Abnormality of the Achilles tendon (HP:0005109)	1.75920502
96	Meningitis (HP:0001287)	1.75847127
97	Irritability (HP:0000737)	1.75725225
98	Impaired platelet aggregation (HP:0003540)	1.74535657
99	Abnormal platelet function (HP:0011869)	1.74535657
100	Orchitis (HP:0100796)	1.72550952

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PRPF4B	4.83544524
2	TAOK3	4.31525243
3	MAP4K1	3.31998503
4	TAOK2	2.74271111
5	GRK6	2.72829046
6	FGFR4	2.70633282
7	TYK2	2.65495623
8	PIK3CG	2.48397885
9	TXK	2.25097115
10	MAP2K3	2.21503355
11	BLK	2.09362057
12	IKBKE	2.02835111
13	JAK1	1.95734206
14	ERN1	1.95682939
15	MAP3K3	1.93676961
16	FGFR3	1.85293565
17	FES	1.71102054
18	CAMKK2	1.65428702
19	ZAP70	1.63123063
20	MAP3K11	1.53161156
21	JAK3	1.51400201
22	TBK1	1.50751314
23	RIPK4	1.48455934
24	NLK	1.46432936
25	TAOK1	1.39461273
26	ITK	1.38158631
27	BTK	1.34606921
28	CSK	1.29113149
29	MAP3K1	1.29004072
30	SYK	1.25365112
31	MAP3K14	1.22873629
32	MAP3K13	1.22054955
33	LCK	1.21411567
34	HCK	1.16709153
35	TNK2	1.16389732
36	TRIB3	1.15252810
37	JAK2	1.14171353
38	EPHB1	1.07042026
39	KIT	1.04406503
40	CSF1R	1.02975350
41	PIM1	1.02931310
42	MAPK11	0.98591532
43	RIPK1	0.97621681
44	PDK1	0.96892804
45	TRPM7	0.94638272
46	MAP3K5	0.94000048
47	STK38	0.88449925
48	TEC	0.88434731
49	SMG1	0.88252239
50	PIK3CA	0.85706646
51	SGK2	0.84343663
52	MAP3K2	0.83276846
53	LYN	0.81037316
54	CDK4	0.80856269
55	MARK2	0.80186561
56	MELK	0.77823755
57	MAP3K10	0.77493680
58	SGK3	0.74598030
59	MAPK12	0.73596289
60	DYRK1A	0.72171994
61	CAMKK1	0.72013966
62	EPHA3	0.71738800
63	STK4	0.71731620
64	TGFBR2	0.70207055
65	PRKAA2	0.69679063
66	PDPK1	0.68690389
67	CDK6	0.68227681
68	PRKCQ	0.67775777
69	PTK6	0.67185449
70	SCYL2	0.65663280
71	GRK5	0.65455204
72	MAP2K2	0.65349071
73	STK10	0.62375721
74	PRKACG	0.62311830
75	STK11	0.62226858
76	RET	0.60763658
77	ERBB2	0.59705783
78	CDK12	0.59439511
79	MAP2K4	0.58619201
80	BMPR2	0.58214987
81	FGR	0.57958702
82	MAP3K7	0.55563893
83	CAMK4	0.50470999
84	MARK3	0.50373320
85	IGF1R	0.50105181
86	MAPK7	0.49783748
87	IKBKB	0.47635465
88	KSR2	0.47469420
89	IRAK4	0.45085735
90	HIPK2	0.44412130
91	FYN	0.44252507
92	SGK494	0.43155142
93	SGK223	0.43155142
94	DYRK1B	0.41908121
95	YES1	0.41608689
96	SGK1	0.41552629
97	PINK1	0.37589403
98	PTK2B	0.36893393
99	SIK1	0.35927932
100	LRRK2	0.35337976

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.39198935
2	Caffeine metabolism_Homo sapiens_hsa00232	4.31411363
3	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.96107731
4	Complement and coagulation cascades_Homo sapiens_hsa04610	3.94854628
5	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.50962036
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.42553196
7	Retinol metabolism_Homo sapiens_hsa00830	3.37024427
8	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	3.00543747
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.90420190
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.80736170
11	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.74257495
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.71252896
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.70557760
14	Arginine biosynthesis_Homo sapiens_hsa00220	2.41910643
15	Fatty acid degradation_Homo sapiens_hsa00071	2.22958777
16	Phenylalanine metabolism_Homo sapiens_hsa00360	2.21424761
17	Tyrosine metabolism_Homo sapiens_hsa00350	2.15909013
18	Butanoate metabolism_Homo sapiens_hsa00650	2.08461624
19	Bile secretion_Homo sapiens_hsa04976	1.92632252
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.83183979
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.82265167
22	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.74203654
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.71875717
24	Histidine metabolism_Homo sapiens_hsa00340	1.61874187
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.56141379
26	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.48180276
27	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.43113535
28	PPAR signaling pathway_Homo sapiens_hsa03320	1.39790084
29	Peroxisome_Homo sapiens_hsa04146	1.34782877
30	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.28311484
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.17983949
32	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.17929989
33	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.12350318
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11715766
35	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.08435336
36	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07953072
37	beta-Alanine metabolism_Homo sapiens_hsa00410	1.04234260
38	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.98979096
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.94953275
40	Prion diseases_Homo sapiens_hsa05020	0.91460034
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.86902738
42	ABC transporters_Homo sapiens_hsa02010	0.80172841
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.75255582
44	Lysine degradation_Homo sapiens_hsa00310	0.73758086
45	Carbon metabolism_Homo sapiens_hsa01200	0.71224244
46	Fatty acid metabolism_Homo sapiens_hsa01212	0.70584388
47	Fat digestion and absorption_Homo sapiens_hsa04975	0.64473407
48	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64267884
49	Arginine and proline metabolism_Homo sapiens_hsa00330	0.63780318
50	Sulfur relay system_Homo sapiens_hsa04122	0.59704541
51	Propanoate metabolism_Homo sapiens_hsa00640	0.59485453
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.58439041
53	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.53925304
54	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.52207242
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41417661
56	One carbon pool by folate_Homo sapiens_hsa00670	0.36114737
57	Insulin resistance_Homo sapiens_hsa04931	0.35793328
58	Pertussis_Homo sapiens_hsa05133	0.35284708
59	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.33973125
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.33591200
61	Sulfur metabolism_Homo sapiens_hsa00920	0.30487411
62	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27977743
63	Metabolic pathways_Homo sapiens_hsa01100	0.27107743
64	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24511280
65	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20308474
66	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.17541131
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.16965576
68	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.16725855
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.16563579
70	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.14259149
71	Other glycan degradation_Homo sapiens_hsa00511	0.12703540
72	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.12444664
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.10611722
74	Leishmaniasis_Homo sapiens_hsa05140	0.10145959
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.07818828
76	Acute myeloid leukemia_Homo sapiens_hsa05221	0.07671788
77	Non-small cell lung cancer_Homo sapiens_hsa05223	0.07551821
78	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.06109796
79	Glucagon signaling pathway_Homo sapiens_hsa04922	0.05367678
80	Osteoclast differentiation_Homo sapiens_hsa04380	0.05125616
81	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.04077902
82	Fatty acid elongation_Homo sapiens_hsa00062	0.03029557
83	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.02858274
84	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	-0.0969863
85	African trypanosomiasis_Homo sapiens_hsa05143	-0.0908712
86	Influenza A_Homo sapiens_hsa05164	-0.0895993
87	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	-0.0877675
88	Leukocyte transendothelial migration_Homo sapiens_hsa04670	-0.0876656
89	Serotonergic synapse_Homo sapiens_hsa04726	-0.0848073
90	Amoebiasis_Homo sapiens_hsa05146	-0.0654864
91	Selenocompound metabolism_Homo sapiens_hsa00450	-0.0612596
92	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	-0.0510588
93	Inositol phosphate metabolism_Homo sapiens_hsa00562	-0.0406936
94	Glycerophospholipid metabolism_Homo sapiens_hsa00564	-0.0329000
95	Hepatitis C_Homo sapiens_hsa05160	-0.0312260
96	Measles_Homo sapiens_hsa05162	-0.0240434
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	-0.0185879
98	Platelet activation_Homo sapiens_hsa04611	-0.0183901
99	FoxO signaling pathway_Homo sapiens_hsa04068	-0.0073584
100	AMPK signaling pathway_Homo sapiens_hsa04152	-0.0043831

KRT17P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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