KRT18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma secretion (GO:0072643)7.31532848
2bundle of His cell to Purkinje myocyte communication (GO:0086069)6.33530998
3intestinal epithelial cell development (GO:0060576)5.64318300
4regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.91627803
5calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.90852455
6positive regulation of keratinocyte differentiation (GO:0045618)4.64086379
7hemidesmosome assembly (GO:0031581)4.59907036
8positive regulation of Cdc42 GTPase activity (GO:0043089)4.57652661
9regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.50167701
10* hepatocyte apoptotic process (GO:0097284)4.48814991
11sulfur amino acid catabolic process (GO:0000098)4.36048698
12tight junction assembly (GO:0070830)4.24230246
13regulation of cell proliferation involved in kidney development (GO:1901722)4.13813515
14response to nitrosative stress (GO:0051409)4.07626604
15positive regulation of epidermal cell differentiation (GO:0045606)4.04791568
16desmosome organization (GO:0002934)3.95532005
17regulation of water loss via skin (GO:0033561)3.94940427
18pentose-phosphate shunt (GO:0006098)3.86266319
19COPI coating of Golgi vesicle (GO:0048205)3.72633836
20Golgi transport vesicle coating (GO:0048200)3.72633836
21NADPH regeneration (GO:0006740)3.61872327
22lung epithelium development (GO:0060428)3.60731010
23branching involved in salivary gland morphogenesis (GO:0060445)3.55594299
24glucose catabolic process (GO:0006007)3.54699673
25proline biosynthetic process (GO:0006561)3.52880778
26branching involved in mammary gland duct morphogenesis (GO:0060444)3.51728682
27trophectodermal cell differentiation (GO:0001829)3.51526818
28glucose 6-phosphate metabolic process (GO:0051156)3.49787957
29cysteine metabolic process (GO:0006534)3.48013934
30xenobiotic catabolic process (GO:0042178)3.45981059
31cell differentiation involved in embryonic placenta development (GO:0060706)3.40148814
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.35702263
33mesodermal cell differentiation (GO:0048333)3.34890699
34response to food (GO:0032094)3.34635523
35L-ascorbic acid metabolic process (GO:0019852)3.31212686
36mesonephros development (GO:0001823)3.30249084
37cellular glucuronidation (GO:0052695)3.29170737
38glucuronate metabolic process (GO:0019585)3.26307794
39uronic acid metabolic process (GO:0006063)3.26307794
40regulation of cholesterol homeostasis (GO:2000188)3.18284960
41activation of Rac GTPase activity (GO:0032863)3.18180812
42pyrimidine-containing compound transmembrane transport (GO:0072531)3.17085644
43epithelial cell-cell adhesion (GO:0090136)3.16604515
44peptidyl-arginine omega-N-methylation (GO:0035247)3.16467534
45establishment of skin barrier (GO:0061436)3.12142900
46negative regulation of cell size (GO:0045792)3.11386781
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10777852
48negative regulation of keratinocyte proliferation (GO:0010839)3.08879466
49pentose metabolic process (GO:0019321)3.08716065
50regulation of mammary gland epithelial cell proliferation (GO:0033599)3.07641658
51regulation of keratinocyte differentiation (GO:0045616)3.06128608
52skin morphogenesis (GO:0043589)3.05900302
53gap junction assembly (GO:0016264)3.05622450
54epithelial cell differentiation involved in prostate gland development (GO:0060742)3.04709877
55bile acid and bile salt transport (GO:0015721)3.02530992
56positive regulation of epidermis development (GO:0045684)3.01885900
57intestinal cholesterol absorption (GO:0030299)3.00756462
58glutathione derivative metabolic process (GO:1901685)2.99289159
59glutathione derivative biosynthetic process (GO:1901687)2.99289159
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.98792219
61positive regulation of pseudopodium assembly (GO:0031274)2.98359573
62norepinephrine metabolic process (GO:0042415)2.98247774
63protein autoprocessing (GO:0016540)2.98084831
64multicellular organismal water homeostasis (GO:0050891)2.97461367
65negative regulation of cell fate specification (GO:0009996)2.97422726
66regulation of cardioblast differentiation (GO:0051890)2.96314680
67maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.96198948
68regulation of centriole replication (GO:0046599)2.94506530
69amyloid precursor protein metabolic process (GO:0042982)2.93755617
70regulation of hippo signaling (GO:0035330)2.93408739
71ear development (GO:0043583)2.92474073
72proteasome assembly (GO:0043248)2.90302400
73diterpenoid biosynthetic process (GO:0016102)2.90204404
74nucleobase-containing small molecule interconversion (GO:0015949)2.90088638
75focal adhesion assembly (GO:0048041)2.88068017
76cell-substrate adherens junction assembly (GO:0007045)2.88068017
77folic acid transport (GO:0015884)2.87020843
78membrane budding (GO:0006900)2.86930505
79embryonic skeletal joint morphogenesis (GO:0060272)2.85819854
80GDP-mannose metabolic process (GO:0019673)2.85769726
81phospholipid homeostasis (GO:0055091)2.85212819
82galactose catabolic process (GO:0019388)2.83092991
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.83065576
84L-phenylalanine metabolic process (GO:0006558)2.83065576
85biotin metabolic process (GO:0006768)2.82342955
86reverse cholesterol transport (GO:0043691)2.82065021
87lung vasculature development (GO:0060426)2.81532333
88embryonic eye morphogenesis (GO:0048048)2.81381754
89mitotic chromosome condensation (GO:0007076)2.80007126
90response to water (GO:0009415)2.78949236
91water homeostasis (GO:0030104)2.77981014
92intestinal absorption (GO:0050892)2.77646964
93nephron tubule formation (GO:0072079)2.77213906
94folic acid-containing compound biosynthetic process (GO:0009396)2.76095536
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75985542
96positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.75728831
97respiratory tube development (GO:0030323)2.75042391
98formation of translation preinitiation complex (GO:0001731)2.74843276
99negative regulation of kidney development (GO:0090185)2.74026642
100cell adhesion mediated by integrin (GO:0033627)2.73903334
101cell-cell junction assembly (GO:0007043)2.72855248
102regulation of apoptotic process involved in morphogenesis (GO:1902337)2.72716618
103muscle atrophy (GO:0014889)2.72629038
104pteridine-containing compound biosynthetic process (GO:0042559)2.71848954
105positive regulation of cellular amine metabolic process (GO:0033240)2.71092610
106lung-associated mesenchyme development (GO:0060484)2.71049232
107ER overload response (GO:0006983)2.69468591
108vagina development (GO:0060068)2.69018053
109striated muscle atrophy (GO:0014891)2.67408597
110regulation of transforming growth factor beta2 production (GO:0032909)2.67261774
111regulation of cellular amino acid metabolic process (GO:0006521)2.66662343
112maternal placenta development (GO:0001893)2.65992137
113adherens junction assembly (GO:0034333)2.65341764
114protein retention in ER lumen (GO:0006621)2.64617825
115lung secretory cell differentiation (GO:0061140)2.64431920
1164-hydroxyproline metabolic process (GO:0019471)2.62678433
117cardiac right ventricle morphogenesis (GO:0003215)2.62403529
118protein-lipid complex remodeling (GO:0034368)2.60694780
119macromolecular complex remodeling (GO:0034367)2.60694780
120plasma lipoprotein particle remodeling (GO:0034369)2.60694780
121keratinocyte development (GO:0003334)2.60494539
122protein complex localization (GO:0031503)2.60293467
123fructose metabolic process (GO:0006000)2.59678335
124low-density lipoprotein particle remodeling (GO:0034374)2.59625677
125spliceosomal tri-snRNP complex assembly (GO:0000244)2.59265371
126regulation of pseudopodium assembly (GO:0031272)2.58902161
127peptidyl-arginine methylation (GO:0018216)2.58403302
128peptidyl-arginine N-methylation (GO:0035246)2.58403302
129establishment of apical/basal cell polarity (GO:0035089)2.57795454
130L-phenylalanine catabolic process (GO:0006559)2.57580927
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.57580927
132regulation of chemokine secretion (GO:0090196)2.56712104
133high-density lipoprotein particle remodeling (GO:0034375)2.56255030
134positive regulation of protein localization to plasma membrane (GO:1903078)2.55729582
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54929576
136negative regulation of fibrinolysis (GO:0051918)2.54508830
137cellular protein complex localization (GO:0034629)2.53874792
138glandular epithelial cell differentiation (GO:0002067)2.53732246
139protein maturation by protein folding (GO:0022417)2.53700333
140nuclear envelope reassembly (GO:0031468)2.53424250
141mitotic nuclear envelope reassembly (GO:0007084)2.53424250
142vitamin transport (GO:0051180)2.52985957
143lung lobe morphogenesis (GO:0060463)2.52656975
144folic acid metabolic process (GO:0046655)2.51666101
145homocysteine metabolic process (GO:0050667)2.50816196
146DNA unwinding involved in DNA replication (GO:0006268)2.50252153
147regulation of translational fidelity (GO:0006450)2.50155631
148maintenance of gastrointestinal epithelium (GO:0030277)2.48944522
149viral mRNA export from host cell nucleus (GO:0046784)2.48902019
150regulation of podosome assembly (GO:0071801)2.48898522
151ribosome biogenesis (GO:0042254)2.48323667
152hippo signaling (GO:0035329)2.46575433
153regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.46180906
154proline metabolic process (GO:0006560)2.46145650
155ribosome assembly (GO:0042255)2.45644860
156negative regulation of cell fate commitment (GO:0010454)2.45592964
157retinal metabolic process (GO:0042574)2.45357065
158primary alcohol catabolic process (GO:0034310)2.44802647
159positive regulation of actin filament depolymerization (GO:0030836)2.44793324
160negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.42143097
161transcytosis (GO:0045056)2.42102854
162embryonic camera-type eye morphogenesis (GO:0048596)2.42058474
163embryonic foregut morphogenesis (GO:0048617)2.41905110
164L-serine metabolic process (GO:0006563)2.41449690
165histone arginine methylation (GO:0034969)2.41375643
166NADH metabolic process (GO:0006734)2.40759508
167regulation of epidermal cell differentiation (GO:0045604)2.40738937
168regulation of keratinocyte proliferation (GO:0010837)2.40654412
169regulation of bile acid biosynthetic process (GO:0070857)2.40636751
170regulation of cholesterol biosynthetic process (GO:0045540)2.40613655
171COPII vesicle coating (GO:0048208)2.40047547
172urea cycle (GO:0000050)2.39657809
173regulation of lipoprotein particle clearance (GO:0010984)2.39263749
174regulation of cholesterol metabolic process (GO:0090181)2.38657583
175negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.37701359
176amyloid precursor protein catabolic process (GO:0042987)2.37363548

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.75717284
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.30708654
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.01104028
4E2F7_22180533_ChIP-Seq_HELA_Human3.61365382
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.24364788
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.18551941
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05135571
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.87696848
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.82628645
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.81878559
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68607162
12* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.58759160
13* LXR_22158963_ChIP-Seq_LIVER_Mouse2.49534858
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.46862284
15* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.44612094
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44413918
17ZNF263_19887448_ChIP-Seq_K562_Human2.42989731
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.39110020
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.38482283
20CLOCK_20551151_ChIP-Seq_293T_Human2.29922244
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25936297
22* GATA4_25053715_ChIP-Seq_YYC3_Human2.22117753
23TRIM28_21343339_ChIP-Seq_HEK293_Human2.21151677
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.11114382
25* GATA6_25053715_ChIP-Seq_YYC3_Human2.08794262
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03416936
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.02911886
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.01647828
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.00835981
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98710447
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.97235419
32DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.95674500
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92812219
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91245832
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.89783834
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.89783834
37SOX2_20726797_ChIP-Seq_SW620_Human1.86261177
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85772490
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.83815715
40HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83015625
41* ATF3_27146783_Chip-Seq_COLON_Human1.80857564
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80347324
43STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.78065687
44NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77982829
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.76584114
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.75021805
47RACK7_27058665_Chip-Seq_MCF-7_Human1.73816175
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72762144
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72149073
50* AR_21909140_ChIP-Seq_LNCAP_Human1.69581800
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68167725
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.67533187
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66987390
54* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62156641
55XRN2_22483619_ChIP-Seq_HELA_Human1.61666327
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.61227524
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61130219
58DCP1A_22483619_ChIP-Seq_HELA_Human1.59810673
59* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.59302658
60* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.57934311
61SALL4_18804426_ChIP-ChIP_XEN_Mouse1.57901857
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52136068
63* RUNX1_27514584_Chip-Seq_MCF-7_Human1.48674933
64* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47499950
65KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.46952700
66* GATA3_24758297_ChIP-Seq_MCF-7_Human1.44458584
67* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42263093
68* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.37849460
69* KDM5A_27292631_Chip-Seq_BREAST_Human1.35720275
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.32444776
71LXR_22292898_ChIP-Seq_THP-1_Human1.32184719
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30784807
73GABP_19822575_ChIP-Seq_HepG2_Human1.29597356
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.28769492
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27229960
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26892013
77SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.25792339
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25613186
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24184084
80STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23918756
81P63_26484246_Chip-Seq_KERATINOCYTES_Human1.23702323
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23333821
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23286566
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.22036477
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.21754553
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20912640
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20171881
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19617977
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19148934
90CHD1_26751641_Chip-Seq_LNCaP_Human1.18933576
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17877086
92KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.17714521
93NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15854776
94CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15740457
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15085201
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14547834
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12802226
98* ESR1_20079471_ChIP-ChIP_T-47D_Human1.12607546
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.11087353
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08862013
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.08859932
102ETS1_20019798_ChIP-Seq_JURKAT_Human1.08842064
103TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07283555
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06739532
105* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05990980
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05932270
107MYC_22102868_ChIP-Seq_BL_Human1.05793937
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.04215139
109ELK1_22589737_ChIP-Seq_MCF10A_Human1.03383235
110E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03374916
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02635988
112ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02590440
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02220477
114TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.00803327
115MYC_18555785_ChIP-Seq_MESCs_Mouse1.00544387
116ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00416067
117TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.00152784
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98515887
119* KLF5_25053715_ChIP-Seq_YYC3_Human0.98079097
120* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95873058
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95464935
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95126869
123* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93587434
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.93495184
125SMC4_20622854_ChIP-Seq_HELA_Human0.93379941
126E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93339240
127P68_20966046_ChIP-Seq_HELA_Human0.92951161
128PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92520066
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92305222
130NANOG_18692474_ChIP-Seq_MEFs_Mouse0.91734241
131* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90606646
132* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88475438
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88230563
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87500806
135SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86571129
136UBF1/2_26484160_Chip-Seq_HMECs_Human0.85561838
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.85408742
138* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.84524861
139RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82514636
140SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81816770
141* GATA2_21666600_ChIP-Seq_HMVEC_Human0.81691729
142ELF5_23300383_ChIP-Seq_T47D_Human0.80595934
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79205539
144CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75990424
145CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75284343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.90027717
2MP0004264_abnormal_extraembryonic_tissu4.01966863
3MP0000537_abnormal_urethra_morphology3.12077737
4MP0002139_abnormal_hepatobiliary_system3.08139055
5MP0001666_abnormal_nutrient_absorption2.80706020
6MP0005085_abnormal_gallbladder_physiolo2.79972551
7MP0002254_reproductive_system_inflammat2.64763683
8MP0008875_abnormal_xenobiotic_pharmacok2.63264399
9MP0005365_abnormal_bile_salt2.57194099
10MP0004233_abnormal_muscle_weight2.52848443
11MP0009840_abnormal_foam_cell2.48867815
12MP0010352_gastrointestinal_tract_polyps2.47299323
13MP0010678_abnormal_skin_adnexa2.22063412
14MP0004019_abnormal_vitamin_homeostasis2.13271457
15MP0005360_urolithiasis2.09909393
16MP0004185_abnormal_adipocyte_glucose2.05619438
17MP0003566_abnormal_cell_adhesion2.03421415
18MP0002796_impaired_skin_barrier1.99533111
19MP0003123_paternal_imprinting1.94703310
20MP0000462_abnormal_digestive_system1.90430093
21MP0005083_abnormal_biliary_tract1.88454050
22MP0003300_gastrointestinal_ulcer1.85356861
23MP0003453_abnormal_keratinocyte_physiol1.82735799
24MP0002098_abnormal_vibrissa_morphology1.82385795
25MP0005377_hearing/vestibular/ear_phenot1.77845219
26MP0003878_abnormal_ear_physiology1.77845219
27MP0005451_abnormal_body_composition1.76134233
28MP0000579_abnormal_nail_morphology1.75822582
29MP0003705_abnormal_hypodermis_morpholog1.73876523
30MP0003252_abnormal_bile_duct1.66093546
31MP0005023_abnormal_wound_healing1.65211774
32MP0003693_abnormal_embryo_hatching1.64682347
33MP0009780_abnormal_chondrocyte_physiolo1.64422793
34MP0010030_abnormal_orbit_morphology1.63295888
35MP0000383_abnormal_hair_follicle1.52893372
36MP0002249_abnormal_larynx_morphology1.49234071
37MP0010329_abnormal_lipoprotein_level1.49095730
38MP0009053_abnormal_anal_canal1.48781798
39MP0001849_ear_inflammation1.45938738
40MP0001346_abnormal_lacrimal_gland1.45210425
41MP0003806_abnormal_nucleotide_metabolis1.44897037
42MP0008932_abnormal_embryonic_tissue1.42199612
43MP0009672_abnormal_birth_weight1.41110024
44MP0002138_abnormal_hepatobiliary_system1.39356848
45MP0003866_abnormal_defecation1.38295824
46MP0009643_abnormal_urine_homeostasis1.37130311
47MP0003942_abnormal_urinary_system1.36476754
48MP0003111_abnormal_nucleus_morphology1.36158929
49MP0000477_abnormal_intestine_morphology1.35268251
50MP0010094_abnormal_chromosome_stability1.34026353
51MP0000678_abnormal_parathyroid_gland1.33809445
52MP0003077_abnormal_cell_cycle1.29734252
53MP0003868_abnormal_feces_composition1.29724386
54MP0002877_abnormal_melanocyte_morpholog1.28677221
55MP0005501_abnormal_skin_physiology1.26590031
56MP0001216_abnormal_epidermal_layer1.25167788
57MP0006054_spinal_hemorrhage1.24250679
58MP0002060_abnormal_skin_morphology1.23395148
59MP0000613_abnormal_salivary_gland1.20638538
60MP0010155_abnormal_intestine_physiology1.18880356
61MP0003186_abnormal_redox_activity1.17077559
62MP0000490_abnormal_crypts_of1.16973779
63MP0001881_abnormal_mammary_gland1.14672719
64MP0004272_abnormal_basement_membrane1.14001913
65MP0005332_abnormal_amino_acid1.13638542
66MP0001727_abnormal_embryo_implantation1.13410683
67MP0001672_abnormal_embryogenesis/_devel1.11182331
68MP0005380_embryogenesis_phenotype1.11182331
69MP0005220_abnormal_exocrine_pancreas1.10819893
70MP0000627_abnormal_mammary_gland1.10749131
71MP0005408_hypopigmentation1.10025962
72MP0000609_abnormal_liver_physiology1.09663451
73MP0003315_abnormal_perineum_morphology1.09018630
74MP0003119_abnormal_digestive_system1.08288890
75* MP0002080_prenatal_lethality1.08280878
76MP0001756_abnormal_urination1.07671876
77MP0002234_abnormal_pharynx_morphology1.07222061
78MP0000566_synostosis1.07142565
79* MP0001697_abnormal_embryo_size1.06383827
80MP0003195_calcinosis1.05894727
81MP0000003_abnormal_adipose_tissue1.05550902
82MP0003984_embryonic_growth_retardation1.05542469
83MP0001873_stomach_inflammation1.05089958
84MP0008004_abnormal_stomach_pH1.05019993
85MP0000377_abnormal_hair_follicle1.02311862
86MP0005248_abnormal_Harderian_gland1.01273880
87MP0005058_abnormal_lysosome_morphology1.01106845
88MP0000762_abnormal_tongue_morphology1.00279346
89MP0005367_renal/urinary_system_phenotyp0.99562312
90MP0000516_abnormal_urinary_system0.99562312
91MP0003936_abnormal_reproductive_system0.99293020
92MP0004782_abnormal_surfactant_physiolog0.98197508
93MP0000350_abnormal_cell_proliferation0.97298483
94MP0005076_abnormal_cell_differentiation0.96391459
95MP0004957_abnormal_blastocyst_morpholog0.96087227
96MP0008260_abnormal_autophagy0.95353775
97MP0002089_abnormal_postnatal_growth/wei0.94222120
98MP0003115_abnormal_respiratory_system0.93690769
99MP0002697_abnormal_eye_size0.93387366
100MP0004858_abnormal_nervous_system0.92873226
101MP0000647_abnormal_sebaceous_gland0.90351321
102MP0001661_extended_life_span0.89734459
103MP0000427_abnormal_hair_cycle0.89425706
104MP0003011_delayed_dark_adaptation0.89053126
105MP0002085_abnormal_embryonic_tissue0.88737690
106MP0001340_abnormal_eyelid_morphology0.88246056
107MP0009931_abnormal_skin_appearance0.86357251
108MP0001348_abnormal_lacrimal_gland0.83689535
109MP0008789_abnormal_olfactory_epithelium0.83133485
110MP0003941_abnormal_skin_development0.82187782
111MP0005084_abnormal_gallbladder_morpholo0.82145546
112* MP0002086_abnormal_extraembryonic_tissu0.81539761
113MP0002136_abnormal_kidney_physiology0.80498739
114MP0003191_abnormal_cellular_cholesterol0.79914598
115MP0004381_abnormal_hair_follicle0.78959208
116MP0005319_abnormal_enzyme/_coenzyme0.78781100
117MP0002118_abnormal_lipid_homeostasis0.77511187
118MP0003786_premature_aging0.77075467
119MP0005666_abnormal_adipose_tissue0.75685144
120MP0004947_skin_inflammation0.74882074
121MP0009384_cardiac_valve_regurgitation0.72920624
122MP0000750_abnormal_muscle_regeneration0.72594784
123MP0005257_abnormal_intraocular_pressure0.72026541
124MP0000358_abnormal_cell_content/0.71845961
125MP0001663_abnormal_digestive_system0.71642651
126MP0003718_maternal_effect0.71501147
127MP0004197_abnormal_fetal_growth/weight/0.71270858
128MP0005670_abnormal_white_adipose0.70632210
129MP0005381_digestive/alimentary_phenotyp0.70359415
130MP0009379_abnormal_foot_pigmentation0.70275518
131MP0002084_abnormal_developmental_patter0.70067954
132MP0005395_other_phenotype0.69864896
133MP0009703_decreased_birth_body0.69825650
134MP0003890_abnormal_embryonic-extraembry0.69244708
135MP0000534_abnormal_ureter_morphology0.67767751
136MP0000538_abnormal_urinary_bladder0.67635439
137* MP0000598_abnormal_liver_morphology0.66940290
138MP0000467_abnormal_esophagus_morphology0.66721322
139MP0003937_abnormal_limbs/digits/tail_de0.66679662
140MP0001730_embryonic_growth_arrest0.66615163
141MP0000858_altered_metastatic_potential0.66550527
142MP0001664_abnormal_digestion0.66263942
143MP0002088_abnormal_embryonic_growth/wei0.64793290
144MP0000470_abnormal_stomach_morphology0.64253974
145MP0010771_integument_phenotype0.64001753
146MP0002111_abnormal_tail_morphology0.63247907

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.60170879
2Onycholysis (HP:0001806)4.74356550
3Abnormality of monocarboxylic acid metabolism (HP:0010996)4.49101618
4J-shaped sella turcica (HP:0002680)4.21837032
5Septate vagina (HP:0001153)4.15773324
6Intrahepatic cholestasis (HP:0001406)4.07350987
7* Micronodular cirrhosis (HP:0001413)4.02050404
8Pili torti (HP:0003777)3.98150894
9Focal segmental glomerulosclerosis (HP:0000097)3.66190564
10Microglossia (HP:0000171)3.64240931
11Asymmetry of the thorax (HP:0001555)3.62814412
12* Esophageal varix (HP:0002040)3.60493266
13Glomerulosclerosis (HP:0000096)3.36278615
14Ileus (HP:0002595)3.33873944
15Milia (HP:0001056)3.31583519
16Xanthomatosis (HP:0000991)3.30918279
17Fragile nails (HP:0001808)3.25695540
18Abnormality of the umbilical cord (HP:0010881)3.21065595
19Hypoglycemic coma (HP:0001325)3.18485734
20Interstitial pulmonary disease (HP:0006530)3.14000252
21Deep venous thrombosis (HP:0002625)3.02430731
22Abnormal pancreas size (HP:0012094)2.93902524
23Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90227584
24Hypobetalipoproteinemia (HP:0003563)2.88001249
25Atrophic scars (HP:0001075)2.86525552
26Flat acetabular roof (HP:0003180)2.86346230
27Hypokinesia (HP:0002375)2.85717809
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82284098
29Gout (HP:0001997)2.77651650
30* Abdominal distention (HP:0003270)2.77122644
31Woolly hair (HP:0002224)2.76432473
32Fat malabsorption (HP:0002630)2.73976359
33Abnormality of the gastric mucosa (HP:0004295)2.73074164
34Hypoparathyroidism (HP:0000829)2.72957117
35Abnormality of the fetal cardiovascular system (HP:0010948)2.70444182
36Abnormal umbilical cord blood vessels (HP:0011403)2.70444182
37Single umbilical artery (HP:0001195)2.70444182
38Hypolipoproteinemia (HP:0010981)2.70008176
39Plantar hyperkeratosis (HP:0007556)2.67591889
40Biliary tract neoplasm (HP:0100574)2.64901300
41Hyperacusis (HP:0010780)2.64831588
42Hypoalphalipoproteinemia (HP:0003233)2.61628852
43Vascular calcification (HP:0004934)2.59213071
44Abnormality of the distal phalanges of the toes (HP:0010182)2.58784543
45Abnormal hemoglobin (HP:0011902)2.58377987
46Concave nail (HP:0001598)2.53907371
47Abnormal biliary tract morphology (HP:0012440)2.51176549
48Stenosis of the external auditory canal (HP:0000402)2.49403995
49Abnormal hair laboratory examination (HP:0003328)2.49248319
50Progressive muscle weakness (HP:0003323)2.48309797
51Chromsome breakage (HP:0040012)2.47483064
52Nail dystrophy (HP:0008404)2.46454764
53Hyperlipoproteinemia (HP:0010980)2.44978291
54Abnormalities of placenta or umbilical cord (HP:0001194)2.41557542
55Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41360651
56Short nail (HP:0001799)2.40945634
57Hypoplasia of the uterus (HP:0000013)2.39169706
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.38780026
59Trismus (HP:0000211)2.37605778
60Absent frontal sinuses (HP:0002688)2.37141360
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.34479656
62Aplasia/hypoplasia of the uterus (HP:0008684)2.32341018
63Curly hair (HP:0002212)2.30359296
64Distal lower limb amyotrophy (HP:0008944)2.29814534
65Hypoplasia of dental enamel (HP:0006297)2.28740236
66Alopecia of scalp (HP:0002293)2.26000257
67Hyperammonemia (HP:0001987)2.25512978
68Broad face (HP:0000283)2.25043694
69Conjugated hyperbilirubinemia (HP:0002908)2.24611682
70Bronchomalacia (HP:0002780)2.23867891
71Proximal tubulopathy (HP:0000114)2.23631494
72Amelogenesis imperfecta (HP:0000705)2.23559033
73Pustule (HP:0200039)2.23540626
74Hyperparathyroidism (HP:0000843)2.22666940
75Cardiovascular calcification (HP:0011915)2.22300999
76Spinal cord compression (HP:0002176)2.21624333
7711 pairs of ribs (HP:0000878)2.20852036
78Abnormality of the common coagulation pathway (HP:0010990)2.20440735
79Deformed sella turcica (HP:0002681)2.19521233
80Deviation of the thumb (HP:0009603)2.19371939
81Abnormality of the intrinsic pathway (HP:0010989)2.18678696
82Steatorrhea (HP:0002570)2.17828266
83Testicular atrophy (HP:0000029)2.15039930
84Abnormality of the frontal sinuses (HP:0002687)2.13678696
85Malnutrition (HP:0004395)2.11456395
86Back pain (HP:0003418)2.09810724
87Rectal prolapse (HP:0002035)2.09173748
88Microretrognathia (HP:0000308)2.08808573
89Hyperthyroidism (HP:0000836)2.08469005
90Proximal placement of thumb (HP:0009623)2.05294157
91Sparse lateral eyebrow (HP:0005338)2.04492004
92Progressive sensorineural hearing impairment (HP:0000408)2.03310922
93Hepatocellular carcinoma (HP:0001402)2.03000085
94Congenital ichthyosiform erythroderma (HP:0007431)2.00438043
95Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.97456904
96Reticulocytosis (HP:0001923)1.97074271
97Cervical subluxation (HP:0003308)1.94836621
98Neonatal death (HP:0003811)1.94299887
99Cheilitis (HP:0100825)1.94141711
100Progressive hearing impairment (HP:0001730)1.93966411
101Distal lower limb muscle weakness (HP:0009053)1.92335157
102Abnormality of glycolysis (HP:0004366)1.92190681
103Seborrheic dermatitis (HP:0001051)1.91554456
104Advanced eruption of teeth (HP:0006288)1.91390014
105Spastic diplegia (HP:0001264)1.91066353
106Exocrine pancreatic insufficiency (HP:0001738)1.90950535
107Ragged-red muscle fibers (HP:0003200)1.89660112
108Abnormality of sulfur amino acid metabolism (HP:0004339)1.89630763
109Abnormal blistering of the skin (HP:0008066)1.89337099
110Subacute progressive viral hepatitis (HP:0006572)1.88521408
111Palpitations (HP:0001962)1.87802972
112Mildly elevated creatine phosphokinase (HP:0008180)1.87537728
113Upper limb amyotrophy (HP:0009129)1.87199958
114Distal upper limb amyotrophy (HP:0007149)1.87199958
115Achilles tendon contracture (HP:0001771)1.86824806
116Abnormality of transition element cation homeostasis (HP:0011030)1.85840772
117Hyperactive renin-angiotensin system (HP:0000841)1.85385764
118Unilateral renal agenesis (HP:0000122)1.84809579
119Abnormal tarsal ossification (HP:0008369)1.84503190
120Diaphragmatic weakness (HP:0009113)1.84441739
121Breast carcinoma (HP:0003002)1.84240897
122Abnormality of fatty-acid metabolism (HP:0004359)1.82948035
123Abnormal vertebral ossification (HP:0100569)1.82612930
124Hyperglycinuria (HP:0003108)1.82512177
125Selective tooth agenesis (HP:0001592)1.81778260
126Abnormality of purine metabolism (HP:0004352)1.81730258
127Hypoglycemic seizures (HP:0002173)1.81699591
128Abnormality of urine glucose concentration (HP:0011016)1.81414347
129Glycosuria (HP:0003076)1.81414347
130Vertebral hypoplasia (HP:0008417)1.80292644
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80292644
132Sparse eyelashes (HP:0000653)1.79979034
133Abnormality of the Achilles tendon (HP:0005109)1.78798194
134Termporal pattern (HP:0011008)1.77535726
135Insidious onset (HP:0003587)1.77535726
136Vertebral compression fractures (HP:0002953)1.76966610
137Prolonged partial thromboplastin time (HP:0003645)1.76522155
138Rough bone trabeculation (HP:0100670)1.75393104
139Patellar dislocation (HP:0002999)1.75342422
140Hyperglycemia (HP:0003074)1.75188011
141Uterine neoplasm (HP:0010784)1.75091415
142Stridor (HP:0010307)1.74513299
143Fused cervical vertebrae (HP:0002949)1.74250330
144Pterygium (HP:0001059)1.73044829
145Late onset (HP:0003584)1.72951814
146Osteolytic defects of the hand bones (HP:0009699)1.72919312
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.72919312
148Abnormality of the tricuspid valve (HP:0001702)1.71592947
149Villous atrophy (HP:0011473)1.71447248
150Abnormality of small intestinal villus morphology (HP:0011472)1.71447248
151Abnormality of reticulocytes (HP:0004312)1.70910128
152Hypotrichosis (HP:0001006)1.70516934
153Lip pit (HP:0100267)1.70247300
154Abnormal foot bone ossification (HP:0010675)1.69958012
155Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.69739913
156Reduced subcutaneous adipose tissue (HP:0003758)1.69251147
157Generalized aminoaciduria (HP:0002909)1.68434411
158Abnormality of proline metabolism (HP:0010907)1.68362221
159Hydroxyprolinuria (HP:0003080)1.68362221
160Fragile skin (HP:0001030)1.67758052
161Fasciculations (HP:0002380)1.67164101
162Germ cell neoplasia (HP:0100728)1.66517521
163Abnormality of the preputium (HP:0100587)1.66393163
164Bicornuate uterus (HP:0000813)1.66340828
165Long palpebral fissure (HP:0000637)1.66302654
166Abnormal gallbladder physiology (HP:0012438)1.61987398
167Cholecystitis (HP:0001082)1.61987398
168Thin bony cortex (HP:0002753)1.61844789
169Acanthosis nigricans (HP:0000956)1.61426649
170Renal tubular acidosis (HP:0001947)1.60780882
171Ulnar bowing (HP:0003031)1.60523926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.26240471
2SMG13.21428469
3MAP2K23.16008199
4FRK2.70049791
5VRK22.46738844
6MAP3K32.36181876
7EIF2AK12.10313797
8PBK2.08945320
9LATS12.08905514
10MST1R2.05596486
11EPHA210.6857717
12FER1.91698202
13NME11.87977751
14PTK61.80029990
15PTK21.78689512
16TESK21.68975265
17PAK41.68179825
18MAP3K21.65407661
19MUSK1.59049253
20TESK11.57743436
21ERN11.52821458
22MAP2K11.50764243
23STK38L1.46284139
24MET1.45452091
25NEK61.40596209
26LMTK21.39780431
27TRIB31.39409456
28PLK41.30482651
29PRKCI1.28462319
30MAPK151.26930060
31STK101.22714779
32PRKG21.22708987
33LRRK21.21618650
34EPHB21.18680625
35FGFR41.13083963
36RIPK11.06228042
37ICK1.04855868
38EPHB11.04782565
39NEK91.01205318
40MAP3K110.99628540
41PKN20.98114659
42TAF10.95681048
43SIK30.95336904
44STK390.93585226
45BCKDK0.92853060
46SCYL20.90513364
47SIK10.89320279
48MAP3K80.84424214
49CDK80.84333830
50MAPKAPK30.83004224
51DAPK10.82242941
52BRSK10.79115097
53ERBB20.78851935
54SRPK10.78286428
55CDK90.77706733
56MAP3K90.75511160
57MAP3K120.74124561
58BUB10.73121285
59EPHA30.70578965
60ERBB40.68397458
61PAK30.67805694
62AURKA0.65877164
63IRAK20.65803505
64NUAK10.65686764
65TTN0.65153147
66MAP2K30.64663228
67TAOK30.64097630
68WEE10.64082583
69AKT30.62621047
70CHUK0.62015425
71RPS6KA40.59706920
72CDK60.59556071
73STK30.58570749
74EEF2K0.58449569
75AURKB0.58099119
76PASK0.57803338
77PIK3CA0.55792691
78TRIM280.55360297
79TTK0.51798900
80IRAK30.51280210
81* RPS6KB20.51105047
82DDR20.50580988
83TRPM70.50030142
84EIF2AK20.48473971
85BCR0.47832607
86LIMK10.47824747
87MTOR0.47501928
88PDGFRA0.47074623
89PDPK10.47052208
90CHEK20.47018750
91ZAK0.45212297
92MYLK0.44759527
93TSSK60.44478356
94TAOK10.42253211
95MAP2K60.41785338
96NME20.41716837
97TGFBR10.41585105
98MATK0.41429265
99ARAF0.38851716
100MELK0.38566292
101DYRK1B0.37808898
102* CAMK2B0.37147362
103NEK10.36617394
104ILK0.36254386
105PLK10.35755404
106RPS6KB10.35184113
107KDR0.35156410
108MAP3K10.33695466
109* CAMK2D0.33273611
110ABL20.32888395
111GSK3A0.31923737
112ERBB30.31718892
113BMX0.30108908
114PAK20.29004964
115DAPK30.28076358
116AKT20.27856581
117RPS6KA20.27750478
118RET0.27360745
119TBK10.26177822
120CDK120.24575413
121BRSK20.24528153
122CHEK10.24394249
123FGFR10.24330590
124PIM20.23268530
125EIF2AK30.22976680
126DMPK0.22802131
127GRK60.22752859
128MAP3K100.22001358
129CSNK1E0.21750950
130CDK70.21523251
131PAK10.21087324
132LATS20.20850199
133* CAMK2G0.20585237
134STK160.20316673
135EGFR0.20220325
136CDC70.19996453
137FLT30.19868859
138CSNK1A1L0.19698014
139STK380.17649985

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.52590696
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.33875872
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.99440234
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.63498845
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56685893
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.42709899
7Chemical carcinogenesis_Homo sapiens_hsa052042.32958119
8Fat digestion and absorption_Homo sapiens_hsa049752.15713636
9DNA replication_Homo sapiens_hsa030302.10580946
10Tight junction_Homo sapiens_hsa045302.01654204
11Glutathione metabolism_Homo sapiens_hsa004801.91734478
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.90715174
13Caffeine metabolism_Homo sapiens_hsa002321.73111997
14Nitrogen metabolism_Homo sapiens_hsa009101.71889926
15Selenocompound metabolism_Homo sapiens_hsa004501.71760820
16Sulfur relay system_Homo sapiens_hsa041221.65629156
17Histidine metabolism_Homo sapiens_hsa003401.64988937
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.64550646
19Fatty acid degradation_Homo sapiens_hsa000711.61643260
20Retinol metabolism_Homo sapiens_hsa008301.61272823
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.59718318
22Adherens junction_Homo sapiens_hsa045201.59408270
23Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56607379
24Base excision repair_Homo sapiens_hsa034101.55920352
25Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48767450
26Arginine biosynthesis_Homo sapiens_hsa002201.45418083
27Bladder cancer_Homo sapiens_hsa052191.45395604
28Mismatch repair_Homo sapiens_hsa034301.42221563
29Vitamin B6 metabolism_Homo sapiens_hsa007501.39657966
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38009618
31Tryptophan metabolism_Homo sapiens_hsa003801.36907732
32Hippo signaling pathway_Homo sapiens_hsa043901.33573985
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.33448634
34Folate biosynthesis_Homo sapiens_hsa007901.32954440
35Complement and coagulation cascades_Homo sapiens_hsa046101.31016095
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29410743
37Pentose phosphate pathway_Homo sapiens_hsa000301.29378607
38Galactose metabolism_Homo sapiens_hsa000521.27664692
39Fructose and mannose metabolism_Homo sapiens_hsa000511.26198374
40RNA transport_Homo sapiens_hsa030131.25473547
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.25448466
42Starch and sucrose metabolism_Homo sapiens_hsa005001.24188470
43* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23927600
44Other glycan degradation_Homo sapiens_hsa005111.22546348
45PPAR signaling pathway_Homo sapiens_hsa033201.20433565
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19166692
47Small cell lung cancer_Homo sapiens_hsa052221.17569521
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.16344793
49Spliceosome_Homo sapiens_hsa030401.14587314
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13836446
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.13266787
52Proteasome_Homo sapiens_hsa030501.12167806
53Vitamin digestion and absorption_Homo sapiens_hsa049771.10385535
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09988720
55Linoleic acid metabolism_Homo sapiens_hsa005911.08993146
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08120184
57Steroid biosynthesis_Homo sapiens_hsa001001.08004054
58Phenylalanine metabolism_Homo sapiens_hsa003601.07040330
59Pyrimidine metabolism_Homo sapiens_hsa002401.07000762
60Fatty acid elongation_Homo sapiens_hsa000621.05551388
61Peroxisome_Homo sapiens_hsa041461.03931211
62Thyroid cancer_Homo sapiens_hsa052161.03920670
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02080099
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.00464941
65beta-Alanine metabolism_Homo sapiens_hsa004101.00458509
66Nucleotide excision repair_Homo sapiens_hsa034200.99164047
67ECM-receptor interaction_Homo sapiens_hsa045120.97465100
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93433801
69Chronic myeloid leukemia_Homo sapiens_hsa052200.92706597
70Bile secretion_Homo sapiens_hsa049760.92363418
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.89596723
72Carbon metabolism_Homo sapiens_hsa012000.88905365
73Cell cycle_Homo sapiens_hsa041100.87020256
74AMPK signaling pathway_Homo sapiens_hsa041520.86989483
75Mineral absorption_Homo sapiens_hsa049780.84841051
76Arachidonic acid metabolism_Homo sapiens_hsa005900.82637360
77Protein export_Homo sapiens_hsa030600.81861416
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80376294
79Hepatitis C_Homo sapiens_hsa051600.79464340
80Biosynthesis of amino acids_Homo sapiens_hsa012300.78411074
81Proteoglycans in cancer_Homo sapiens_hsa052050.77605120
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76061730
83Tyrosine metabolism_Homo sapiens_hsa003500.75701966
84Insulin signaling pathway_Homo sapiens_hsa049100.74971906
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74733970
86Non-small cell lung cancer_Homo sapiens_hsa052230.73944769
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72455806
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71824881
89Glycerolipid metabolism_Homo sapiens_hsa005610.71083207
90Acute myeloid leukemia_Homo sapiens_hsa052210.69649541
91Vibrio cholerae infection_Homo sapiens_hsa051100.69567833
92Butanoate metabolism_Homo sapiens_hsa006500.68878851
93Arginine and proline metabolism_Homo sapiens_hsa003300.67033988
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67006034
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66764772
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66680243
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65646207
98mRNA surveillance pathway_Homo sapiens_hsa030150.64625562
99Renal cell carcinoma_Homo sapiens_hsa052110.64602035
100ErbB signaling pathway_Homo sapiens_hsa040120.61934811
101Homologous recombination_Homo sapiens_hsa034400.61432178
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61166501
103Sphingolipid metabolism_Homo sapiens_hsa006000.61002899
104Pancreatic cancer_Homo sapiens_hsa052120.59812575
105Pyruvate metabolism_Homo sapiens_hsa006200.58861293
106Fatty acid metabolism_Homo sapiens_hsa012120.58174816
107Focal adhesion_Homo sapiens_hsa045100.57100731
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.56310788
109N-Glycan biosynthesis_Homo sapiens_hsa005100.56071282
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.54277410
111ABC transporters_Homo sapiens_hsa020100.54116009
112Basal cell carcinoma_Homo sapiens_hsa052170.52969714
113mTOR signaling pathway_Homo sapiens_hsa041500.48972799
114Fanconi anemia pathway_Homo sapiens_hsa034600.47495894
115Insulin resistance_Homo sapiens_hsa049310.47009343
116Prostate cancer_Homo sapiens_hsa052150.46778261
117p53 signaling pathway_Homo sapiens_hsa041150.46746513
118Amoebiasis_Homo sapiens_hsa051460.46537221
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44962695
120Propanoate metabolism_Homo sapiens_hsa006400.43558646
121Glioma_Homo sapiens_hsa052140.43427049
122One carbon pool by folate_Homo sapiens_hsa006700.43402726
123Ribosome_Homo sapiens_hsa030100.41199469
124Melanoma_Homo sapiens_hsa052180.40014838
125Metabolic pathways_Homo sapiens_hsa011000.36464561
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.36087986
127Endometrial cancer_Homo sapiens_hsa052130.34470959
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34390379
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33806420
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33766508
131VEGF signaling pathway_Homo sapiens_hsa043700.33376883
132Renin-angiotensin system_Homo sapiens_hsa046140.33092449
133Shigellosis_Homo sapiens_hsa051310.31090053
134Toxoplasmosis_Homo sapiens_hsa051450.30970790
135TGF-beta signaling pathway_Homo sapiens_hsa043500.30791725
136Hedgehog signaling pathway_Homo sapiens_hsa043400.30328821
137Legionellosis_Homo sapiens_hsa051340.29439096

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