ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	7.15117968
2	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.83129401
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.83129401
4	folic acid-containing compound biosynthetic process (GO:0009396)	5.71576048
5	desmosome organization (GO:0002934)	5.31918687
6	pteridine-containing compound biosynthetic process (GO:0042559)	5.24892463
7	L-serine metabolic process (GO:0006563)	5.18940213
8	mitochondrial RNA metabolic process (GO:0000959)	5.10629564
9	artery smooth muscle contraction (GO:0014824)	5.03250150
10	ribosome biogenesis (GO:0042254)	5.01182851
11	rRNA modification (GO:0000154)	5.00800686
12	sulfur amino acid catabolic process (GO:0000098)	4.99411108
13	regulation of plasminogen activation (GO:0010755)	4.92312851
14	cysteine metabolic process (GO:0006534)	4.79771648
15	adenosine metabolic process (GO:0046085)	4.78958066
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.53019574
17	NADH dehydrogenase complex assembly (GO:0010257)	4.53019574
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.53019574
19	nucleoside transport (GO:0015858)	4.34630261
20	IMP biosynthetic process (GO:0006188)	4.32628292
21	galactose catabolic process (GO:0019388)	4.32015656
22	rRNA methylation (GO:0031167)	4.30983485
23	purine nucleotide salvage (GO:0032261)	4.30307206
24	GTP biosynthetic process (GO:0006183)	4.29671873
25	tonic smooth muscle contraction (GO:0014820)	4.21175440
26	pseudouridine synthesis (GO:0001522)	4.09846017
27	UTP biosynthetic process (GO:0006228)	4.08713724
28	serine family amino acid biosynthetic process (GO:0009070)	4.04846109
29	alternative mRNA splicing, via spliceosome (GO:0000380)	3.99268792
30	aminoglycoside antibiotic metabolic process (GO:0030647)	3.97487953
31	respiratory chain complex IV assembly (GO:0008535)	3.96175533
32	proteasome assembly (GO:0043248)	3.95181929
33	guanosine-containing compound biosynthetic process (GO:1901070)	3.94400089
34	galactose metabolic process (GO:0006012)	3.93131608
35	UTP metabolic process (GO:0046051)	3.85911590
36	hepatocyte apoptotic process (GO:0097284)	3.85146988
37	positive regulation of osteoblast proliferation (GO:0033690)	3.83946791
38	negative regulation of DNA biosynthetic process (GO:2000279)	3.78747666
39	protein complex biogenesis (GO:0070271)	3.73059226
40	white fat cell differentiation (GO:0050872)	3.66163625
41	nucleoside transmembrane transport (GO:1901642)	3.65182301
42	transcription from mitochondrial promoter (GO:0006390)	3.62129107
43	CENP-A containing nucleosome assembly (GO:0034080)	3.61068511
44	oxidative phosphorylation (GO:0006119)	3.57680778
45	IMP metabolic process (GO:0046040)	3.55341485
46	ribonucleoprotein complex biogenesis (GO:0022613)	3.54448314
47	regulation of mitochondrial translation (GO:0070129)	3.50062661
48	tetrahydrofolate metabolic process (GO:0046653)	3.47639393
49	chromatin remodeling at centromere (GO:0031055)	3.44361414
50	cellular component biogenesis (GO:0044085)	3.44193658
51	tRNA modification (GO:0006400)	3.43120038
52	pteridine-containing compound metabolic process (GO:0042558)	3.39747549
53	heme transport (GO:0015886)	3.39301415
54	nuclear envelope reassembly (GO:0031468)	3.38350615
55	mitotic nuclear envelope reassembly (GO:0007084)	3.38350615
56	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.35799852
57	glycoside metabolic process (GO:0016137)	3.34237371
58	protein-cofactor linkage (GO:0018065)	3.32902552
59	folic acid-containing compound metabolic process (GO:0006760)	3.30945916
60	mitochondrial respiratory chain complex assembly (GO:0033108)	3.30612294
61	sulfur amino acid biosynthetic process (GO:0000097)	3.25857223
62	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.25362794
63	negative regulation of keratinocyte proliferation (GO:0010839)	3.17179501
64	regulation of tight junction assembly (GO:2000810)	3.14119539
65	cytochrome complex assembly (GO:0017004)	3.13428082
66	purine ribonucleotide transport (GO:0015868)	3.11414845
67	CTP metabolic process (GO:0046036)	3.10686556
68	CTP biosynthetic process (GO:0006241)	3.10686556
69	energy homeostasis (GO:0097009)	3.10124544
70	nucleotide salvage (GO:0043173)	3.09295179
71	tRNA processing (GO:0008033)	3.05950685
72	mitochondrial calcium ion transport (GO:0006851)	3.05395103
73	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.05303351
74	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.02160411
75	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.98735191
76	positive regulation of endothelial cell differentiation (GO:0045603)	2.98565016
77	adenine nucleotide transport (GO:0051503)	2.98214733
78	ATP hydrolysis coupled proton transport (GO:0015991)	2.95281722
79	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.95281722
80	basic amino acid transport (GO:0015802)	2.92859554
81	inner ear receptor cell development (GO:0060119)	2.91665368
82	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.90966907
83	ribosomal small subunit assembly (GO:0000028)	2.78202225
84	L-methionine salvage (GO:0071267)	2.78121963
85	L-methionine biosynthetic process (GO:0071265)	2.78121963
86	amino acid salvage (GO:0043102)	2.78121963
87	rRNA processing (GO:0006364)	2.77892143
88	regulation of oxidative phosphorylation (GO:0002082)	2.77815083
89	polyamine biosynthetic process (GO:0006596)	2.76699568
90	negative regulation of anoikis (GO:2000811)	2.75144552
91	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.74675780
92	doxorubicin metabolic process (GO:0044598)	2.72087751
93	daunorubicin metabolic process (GO:0044597)	2.72087751
94	polyketide metabolic process (GO:0030638)	2.72087751
95	rRNA metabolic process (GO:0016072)	2.69974704
96	alpha-amino acid biosynthetic process (GO:1901607)	2.69001504
97	vascular smooth muscle contraction (GO:0014829)	2.66672103
98	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.65109941
99	microtubule nucleation (GO:0007020)	2.63013587
100	peptidyl-histidine modification (GO:0018202)	2.61035064

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.68947376
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.54994544
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.17163878
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05791220
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.70890348
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.30716708
7	E2F7_22180533_ChIP-Seq_HELA_Human	2.98935799
8	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.89954318
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.83568527
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.82879660
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.82098284
12	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64666091
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.57574561
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.52874525
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.51452019
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.40561970
17	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.38913339
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38251665
19	GABP_19822575_ChIP-Seq_HepG2_Human	2.32348282
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.23420799
21	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.19182147
22	ZNF263_19887448_ChIP-Seq_K562_Human	2.17857894
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.14937722
24	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.14434148
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.13197379
26	DCP1A_22483619_ChIP-Seq_HELA_Human	2.12517371
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.99802216
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.99401575
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.95743233
30	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93711749
31	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.90800871
32	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.85092685
33	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.76575964
34	AR_21909140_ChIP-Seq_LNCAP_Human	1.75085530
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74373756
36	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73964277
37	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.70745073
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.66545399
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.61156170
40	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.56104500
41	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.48796044
42	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.47898866
43	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.45708458
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.43321276
45	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.42704650
46	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41577866
47	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.41445998
48	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.39940887
49	KDM5A_27292631_Chip-Seq_BREAST_Human	1.39189189
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37978927
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31993707
52	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28671065
53	TTF2_22483619_ChIP-Seq_HELA_Human	1.25045104
54	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.24483401
55	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.24302681
56	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.20509534
57	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.20224293
58	GATA4_25053715_ChIP-Seq_YYC3_Human	1.17008119
59	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.16284375
60	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.13631795
61	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.12686950
62	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.12579546
63	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.05175682
64	ATF3_27146783_Chip-Seq_COLON_Human	1.04471229
65	ELK1_19687146_ChIP-ChIP_HELA_Human	1.02517232
66	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.02182011
67	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.01876548
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01574869
69	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.01340260
70	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.00188039
71	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.95693291
72	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.95671901
73	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.95568623
74	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.93472586
75	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.92948770
76	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.90385341
77	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89524231
78	GATA6_25053715_ChIP-Seq_YYC3_Human	0.89423296
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.88835675
80	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.88686277
81	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.88313375
82	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87769292
83	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.87319111
84	P68_20966046_ChIP-Seq_HELA_Human	0.86598182
85	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.86087293
86	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.85164377
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.85021794
88	EOMES_21245162_ChIP-Seq_HESCs_Human	0.84992941
89	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.84929146
90	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84797687
91	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.83317704
92	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.82814667
93	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.80390103
94	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.79308511
95	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.78839042
96	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.78586546
97	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.77926916
98	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.77909387
99	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.77397828
100	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.77125017

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.10545232
2	MP0002132_abnormal_respiratory_system	4.53873301
3	MP0005670_abnormal_white_adipose	4.25719105
4	MP0001661_extended_life_span	3.82226113
5	MP0003693_abnormal_embryo_hatching	3.47431212
6	MP0004147_increased_porphyrin_level	3.18208889
7	MP0002736_abnormal_nociception_after	2.73994713
8	MP0005646_abnormal_pituitary_gland	2.71474792
9	MP0008872_abnormal_physiological_respon	2.70395060
10	MP0000013_abnormal_adipose_tissue	2.62550376
11	MP0008875_abnormal_xenobiotic_pharmacok	2.54962722
12	MP0003186_abnormal_redox_activity	2.27927841
13	MP0003806_abnormal_nucleotide_metabolis	2.24958756
14	MP0001764_abnormal_homeostasis	2.13751047
15	MP0002938_white_spotting	2.12733323
16	MP0003183_abnormal_peptide_metabolism	2.09711944
17	MP0005332_abnormal_amino_acid	1.92879453
18	MP0004885_abnormal_endolymph	1.91256562
19	MP0000516_abnormal_urinary_system	1.84419508
20	MP0005367_renal/urinary_system_phenotyp	1.84419508
21	MP0008995_early_reproductive_senescence	1.81006764
22	MP0004957_abnormal_blastocyst_morpholog	1.80181552
23	MP0003878_abnormal_ear_physiology	1.67219986
24	MP0005377_hearing/vestibular/ear_phenot	1.67219986
25	MP0003890_abnormal_embryonic-extraembry	1.63549567
26	MP0005085_abnormal_gallbladder_physiolo	1.62494477
27	MP0003786_premature_aging	1.53956567
28	MP0003111_abnormal_nucleus_morphology	1.52333562
29	MP0004043_abnormal_pH_regulation	1.51549715
30	MP0006292_abnormal_olfactory_placode	1.46994442
31	MP0001666_abnormal_nutrient_absorption	1.45895997
32	MP0010234_abnormal_vibrissa_follicle	1.45868728
33	MP0004264_abnormal_extraembryonic_tissu	1.42341253
34	MP0002138_abnormal_hepatobiliary_system	1.41763036
35	MP0005636_abnormal_mineral_homeostasis	1.40105931
36	MP0003718_maternal_effect	1.39091934
37	MP0003942_abnormal_urinary_system	1.37652904
38	MP0004019_abnormal_vitamin_homeostasis	1.33122417
39	MP0001968_abnormal_touch/_nociception	1.30492940
40	MP0002396_abnormal_hematopoietic_system	1.30246796
41	MP0000538_abnormal_urinary_bladder	1.29931050
42	MP0002139_abnormal_hepatobiliary_system	1.29135551
43	MP0000647_abnormal_sebaceous_gland	1.28489159
44	MP0005365_abnormal_bile_salt	1.21795597
45	MP0001756_abnormal_urination	1.20050005
46	MP0004233_abnormal_muscle_weight	1.18658958
47	MP0002160_abnormal_reproductive_system	1.18368816
48	MP0002653_abnormal_ependyma_morphology	1.15971322
49	MP0004185_abnormal_adipocyte_glucose	1.15272292
50	MP0006036_abnormal_mitochondrial_physio	1.13513056
51	MP0008932_abnormal_embryonic_tissue	1.10513417
52	MP0010094_abnormal_chromosome_stability	1.07728226
53	MP0001697_abnormal_embryo_size	1.06536839
54	MP0000534_abnormal_ureter_morphology	1.04227017
55	MP0009643_abnormal_urine_homeostasis	1.03442194
56	MP0002234_abnormal_pharynx_morphology	1.00067174
57	MP0008058_abnormal_DNA_repair	0.99291031
58	MP0004782_abnormal_surfactant_physiolog	0.95269585
59	MP0003315_abnormal_perineum_morphology	0.95219909
60	MP0002254_reproductive_system_inflammat	0.95144020
61	MP0000747_muscle_weakness	0.94910334
62	MP0005319_abnormal_enzyme/_coenzyme	0.93855459
63	MP0003705_abnormal_hypodermis_morpholog	0.91843305
64	MP0010386_abnormal_urinary_bladder	0.89231570
65	MP0000537_abnormal_urethra_morphology	0.85358562
66	MP0005501_abnormal_skin_physiology	0.83988321
67	MP0000003_abnormal_adipose_tissue	0.83761086
68	MP0003077_abnormal_cell_cycle	0.81855461
69	MP0000490_abnormal_crypts_of	0.81533245
70	MP0005084_abnormal_gallbladder_morpholo	0.79837847
71	MP0003937_abnormal_limbs/digits/tail_de	0.79034432
72	MP0005584_abnormal_enzyme/coenzyme_acti	0.78881812
73	MP0000678_abnormal_parathyroid_gland	0.77759686
74	MP0004133_heterotaxia	0.76386068
75	MP0001270_distended_abdomen	0.76338313
76	MP0003936_abnormal_reproductive_system	0.76147076
77	MP0002697_abnormal_eye_size	0.74724669
78	MP0006054_spinal_hemorrhage	0.74027118
79	MP0000762_abnormal_tongue_morphology	0.74015184
80	MP0000627_abnormal_mammary_gland	0.72265367
81	MP0005389_reproductive_system_phenotype	0.71810415
82	MP0003638_abnormal_response/metabolism_	0.70239663
83	MP0002086_abnormal_extraembryonic_tissu	0.69221216
84	MP0002088_abnormal_embryonic_growth/wei	0.67815739
85	MP0001919_abnormal_reproductive_system	0.67174345
86	MP0001730_embryonic_growth_arrest	0.66998813
87	MP0002127_abnormal_cardiovascular_syste	0.66818862
88	MP0002210_abnormal_sex_determination	0.65983164
89	MP0005408_hypopigmentation	0.65069328
90	MP0001145_abnormal_male_reproductive	0.64988838
91	MP0003984_embryonic_growth_retardation	0.63765966
92	MP0005647_abnormal_sex_gland	0.63220189
93	MP0000598_abnormal_liver_morphology	0.62208932
94	MP0000613_abnormal_salivary_gland	0.60909673
95	MP0009697_abnormal_copulation	0.60544167
96	MP0001485_abnormal_pinna_reflex	0.59788045
97	MP0005380_embryogenesis_phenotype	0.59154722
98	MP0001672_abnormal_embryogenesis/_devel	0.59154722
99	MP0006035_abnormal_mitochondrial_morpho	0.58819290
100	MP0002111_abnormal_tail_morphology	0.57971981

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	8.00462965
2	Abnormality of alanine metabolism (HP:0010916)	8.00462965
3	Hyperalaninemia (HP:0003348)	8.00462965
4	Constricted visual fields (HP:0001133)	4.07739097
5	Esophageal varix (HP:0002040)	4.02860736
6	Abnormality of serum amino acid levels (HP:0003112)	3.83254785
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.65311626
8	Abnormal umbilical cord blood vessels (HP:0011403)	3.54180941
9	Single umbilical artery (HP:0001195)	3.54180941
10	Abnormality of the fetal cardiovascular system (HP:0010948)	3.54180941
11	Acute encephalopathy (HP:0006846)	3.45955376
12	Congenital sensorineural hearing impairment (HP:0008527)	3.44280638
13	Acute necrotizing encephalopathy (HP:0006965)	3.36221583
14	Hepatocellular necrosis (HP:0001404)	3.27532813
15	Birth length less than 3rd percentile (HP:0003561)	3.24060598
16	Homocystinuria (HP:0002156)	3.22020889
17	Abnormality of homocysteine metabolism (HP:0010919)	3.22020889
18	Petechiae (HP:0000967)	3.21894287
19	Short middle phalanx of the 5th finger (HP:0004220)	3.21790716
20	Abnormal mitochondria in muscle tissue (HP:0008316)	3.12401907
21	Mitochondrial inheritance (HP:0001427)	3.11917166
22	Increased CSF lactate (HP:0002490)	3.01130257
23	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.95977203
24	Reticulocytopenia (HP:0001896)	2.95585705
25	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.93200513
26	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.84415556
27	Hypoplastic left heart (HP:0004383)	2.81910681
28	Abnormality of pyrimidine metabolism (HP:0004353)	2.80713994
29	Increased serum lactate (HP:0002151)	2.79229927
30	Increased serum pyruvate (HP:0003542)	2.79021458
31	Hyperglycinemia (HP:0002154)	2.78815064
32	Hepatic necrosis (HP:0002605)	2.78335337
33	Progressive macrocephaly (HP:0004481)	2.77130786
34	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.71730335
35	Lactic acidosis (HP:0003128)	2.70673900
36	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.69632921
37	Abnormality of the umbilical cord (HP:0010881)	2.69586264
38	Micronodular cirrhosis (HP:0001413)	2.66324949
39	Acanthocytosis (HP:0001927)	2.59861595
40	Type I transferrin isoform profile (HP:0003642)	2.58039180
41	Patchy hypopigmentation of hair (HP:0011365)	2.56815501
42	Cerebral edema (HP:0002181)	2.54598710
43	Conjugated hyperbilirubinemia (HP:0002908)	2.53946857
44	White forelock (HP:0002211)	2.51042850
45	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.50881441
46	Abnormality of glycolysis (HP:0004366)	2.50037251
47	Complete atrioventricular canal defect (HP:0001674)	2.48396313
48	Poor speech (HP:0002465)	2.47931354
49	Generalized aminoaciduria (HP:0002909)	2.44622368
50	Duplicated collecting system (HP:0000081)	2.44252598
51	Cortical visual impairment (HP:0100704)	2.43550713
52	Nausea (HP:0002018)	2.41122979
53	Reduced subcutaneous adipose tissue (HP:0003758)	2.39986860
54	Ileus (HP:0002595)	2.39205167
55	Abnormality of the renal collecting system (HP:0004742)	2.37843564
56	Abnormality of dental color (HP:0011073)	2.30309915
57	Lethargy (HP:0001254)	2.29884432
58	Proximal tubulopathy (HP:0000114)	2.29592844
59	Chromsome breakage (HP:0040012)	2.26732263
60	Anorexia (HP:0002039)	2.20250769
61	Hypoalphalipoproteinemia (HP:0003233)	2.17699277
62	Macrocytic anemia (HP:0001972)	2.16089033
63	CNS demyelination (HP:0007305)	2.13478689
64	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.10437996
65	Myocardial infarction (HP:0001658)	2.09310247
66	Hypoplastic heart (HP:0001961)	2.08150687
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.08132782
68	Abnormal protein N-linked glycosylation (HP:0012347)	2.08132782
69	Abnormal protein glycosylation (HP:0012346)	2.08132782
70	Abnormal glycosylation (HP:0012345)	2.08132782
71	Myopathic facies (HP:0002058)	2.07556499
72	Reduced antithrombin III activity (HP:0001976)	2.06161468
73	Brushfield spots (HP:0001088)	2.00548218
74	Tetany (HP:0001281)	1.98445347
75	Abnormality of subcutaneous fat tissue (HP:0001001)	1.98038129
76	Facial hemangioma (HP:0000329)	1.96491741
77	Diaphragmatic weakness (HP:0009113)	1.95127037
78	Abnormalities of placenta or umbilical cord (HP:0001194)	1.94374810
79	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.94328811
80	Metabolic acidosis (HP:0001942)	1.92857422
81	Respiratory failure (HP:0002878)	1.91361469
82	Maternal diabetes (HP:0009800)	1.89212495
83	Paralysis (HP:0003470)	1.86204199
84	Ureteral duplication (HP:0000073)	1.81482781
85	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.81041204
86	Hepatocellular carcinoma (HP:0001402)	1.80943136
87	Stenosis of the external auditory canal (HP:0000402)	1.80478273
88	Arteriovenous malformation (HP:0100026)	1.79436088
89	Broad palm (HP:0001169)	1.79316635
90	Neutropenia (HP:0001875)	1.78721607
91	Microretrognathia (HP:0000308)	1.78074334
92	Abnormality of reticulocytes (HP:0004312)	1.76409923
93	Megaloblastic anemia (HP:0001889)	1.76182953
94	Renal tubular acidosis (HP:0001947)	1.75900214
95	Pancytopenia (HP:0001876)	1.75658713
96	Decreased subcutaneous fat (HP:0001002)	1.74011820
97	Spontaneous hematomas (HP:0007420)	1.73866785
98	Exercise intolerance (HP:0003546)	1.73048697
99	Abnormality of methionine metabolism (HP:0010901)	1.72291037
100	Atrioventricular canal defect (HP:0006695)	1.71436359

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	5.28260532
2	EPHA2	3.92638981
3	RPS6KB2	3.69679925
4	VRK2	3.67700096
5	MAP3K3	2.81770384
6	MST4	2.69280705
7	PBK	2.68011523
8	STK39	2.41030134
9	MST1R	2.26395185
10	MAP3K12	2.19228769
11	TLK1	2.05821337
12	CDK9	1.97386788
13	OXSR1	1.97220177
14	NME2	1.94329577
15	BCKDK	1.92335125
16	BUB1	1.90416285
17	EIF2AK1	1.90015371
18	LMTK2	1.85400029
19	STK16	1.72165335
20	PAK4	1.68018961
21	WNK4	1.62972853
22	NUAK1	1.60676415
23	NME1	1.52694918
24	ERN1	1.43219602
25	CCNB1	1.42283967
26	TIE1	1.42126773
27	MAP2K3	1.38921772
28	VRK1	1.37523236
29	JAK3	1.33450394
30	AURKA	1.18640449
31	CDK12	1.17782059
32	FGR	1.17206350
33	TAF1	1.12963914
34	ACVR1B	1.08087393
35	MAP2K2	1.06751674
36	SMG1	1.04156635
37	PRKCI	0.98100310
38	ZAK	0.96068888
39	CAMK2G	0.93752187
40	MAPKAPK5	0.89426755
41	PRKG2	0.88537877
42	CAMK2B	0.87351454
43	ABL2	0.84184306
44	EIF2AK3	0.84036609
45	MAP3K11	0.83166076
46	CAMK2D	0.82559935
47	CDK8	0.81126701
48	NEK1	0.79640017
49	CHEK2	0.79565286
50	LIMK1	0.78862036
51	DAPK1	0.78291905
52	TESK1	0.76828966
53	DAPK3	0.76713319
54	CAMK1	0.74091878
55	DYRK2	0.73606638
56	AURKB	0.73446613
57	ILK	0.72397859
58	GRK6	0.71837129
59	CDK7	0.71071114
60	STK4	0.70726352
61	CDK19	0.69928977
62	NEK6	0.69293747
63	EPHB2	0.67620415
64	MAP4K2	0.67567476
65	CSNK1A1	0.64301641
66	MAPKAPK3	0.61935098
67	MAP2K1	0.61607907
68	SCYL2	0.60741932
69	BRSK2	0.60182960
70	AKT3	0.59642352
71	PTK6	0.57650323
72	GRK1	0.57509109
73	MYLK	0.56814558
74	BRSK1	0.56130817
75	CSNK1G3	0.55902850
76	NTRK2	0.55707710
77	STK10	0.55539444
78	PRKCD	0.51999729
79	MET	0.51223026
80	PRKD1	0.51091059
81	AKT2	0.50538777
82	ADRBK1	0.49692440
83	PRKCE	0.49516896
84	RPS6KA5	0.49052861
85	PLK3	0.48705845
86	KDR	0.48023324
87	EIF2AK2	0.47449345
88	IKBKB	0.47034155
89	PLK1	0.46143595
90	TESK2	0.44437024
91	ATR	0.42761949
92	CSNK1A1L	0.42659323
93	PIK3CA	0.41102666
94	TRIM28	0.40811288
95	NTRK3	0.39379852
96	CSNK1G1	0.39005415
97	TSSK6	0.37709938
98	FER	0.35727708
99	MAP3K8	0.35597135
100	CSNK2A1	0.34985308

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.50115326
2	One carbon pool by folate_Homo sapiens_hsa00670	3.25120722
3	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.91684303
4	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.85481050
5	Sulfur relay system_Homo sapiens_hsa04122	2.68763286
6	Sulfur metabolism_Homo sapiens_hsa00920	2.51575547
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.42558660
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.34608468
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.26270464
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.19149551
11	Oxidative phosphorylation_Homo sapiens_hsa00190	2.08836892
12	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.03870615
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.01483515
14	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.88117372
15	Ribosome_Homo sapiens_hsa03010	1.85300189
16	Galactose metabolism_Homo sapiens_hsa00052	1.80535215
17	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.74792475
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.72230678
19	Folate biosynthesis_Homo sapiens_hsa00790	1.69294603
20	DNA replication_Homo sapiens_hsa03030	1.64120043
21	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.63329831
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62240477
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.61862352
24	Glutathione metabolism_Homo sapiens_hsa00480	1.48866179
25	Parkinsons disease_Homo sapiens_hsa05012	1.46489994
26	Fat digestion and absorption_Homo sapiens_hsa04975	1.45292741
27	Vibrio cholerae infection_Homo sapiens_hsa05110	1.42611999
28	Base excision repair_Homo sapiens_hsa03410	1.40364289
29	Basal transcription factors_Homo sapiens_hsa03022	1.39342731
30	Spliceosome_Homo sapiens_hsa03040	1.31440079
31	RNA polymerase_Homo sapiens_hsa03020	1.31175544
32	Carbon metabolism_Homo sapiens_hsa01200	1.29404122
33	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.23817043
34	RNA transport_Homo sapiens_hsa03013	1.22478999
35	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.22150155
36	Huntingtons disease_Homo sapiens_hsa05016	1.21623439
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18951301
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.17953822
39	RNA degradation_Homo sapiens_hsa03018	1.17251196
40	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.15002619
41	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.13134690
42	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10970710
43	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10445492
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.05540071
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.03717397
46	Pyruvate metabolism_Homo sapiens_hsa00620	1.03550312
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.02512580
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.00609458
49	Fatty acid elongation_Homo sapiens_hsa00062	1.00329474
50	Chemical carcinogenesis_Homo sapiens_hsa05204	1.00233627
51	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98896009
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.98427009
53	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.96416508
54	Metabolic pathways_Homo sapiens_hsa01100	0.95777426
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.94044168
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93740261
57	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.91956177
58	Steroid biosynthesis_Homo sapiens_hsa00100	0.87929616
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.83674482
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.80951123
61	Retinol metabolism_Homo sapiens_hsa00830	0.80378931
62	Purine metabolism_Homo sapiens_hsa00230	0.79231392
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.79138355
64	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78910408
65	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.77285692
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.75650511
67	Homologous recombination_Homo sapiens_hsa03440	0.73189146
68	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.73061101
69	mRNA surveillance pathway_Homo sapiens_hsa03015	0.72625012
70	Peroxisome_Homo sapiens_hsa04146	0.70055810
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.69987153
72	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69709268
73	Pentose phosphate pathway_Homo sapiens_hsa00030	0.68010857
74	Alcoholism_Homo sapiens_hsa05034	0.67721536
75	Butanoate metabolism_Homo sapiens_hsa00650	0.67138028
76	Regulation of autophagy_Homo sapiens_hsa04140	0.66144056
77	Protein export_Homo sapiens_hsa03060	0.65782628
78	Alzheimers disease_Homo sapiens_hsa05010	0.64274750
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.62009450
80	Mismatch repair_Homo sapiens_hsa03430	0.61415879
81	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.61250334
82	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.60180992
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56394105
84	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.55878518
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.55255755
86	Phenylalanine metabolism_Homo sapiens_hsa00360	0.53875809
87	Thyroid cancer_Homo sapiens_hsa05216	0.51981309
88	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.50010685
89	Ether lipid metabolism_Homo sapiens_hsa00565	0.49728727
90	Other glycan degradation_Homo sapiens_hsa00511	0.48803563
91	Fatty acid degradation_Homo sapiens_hsa00071	0.48225083
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.47907287
93	Renin-angiotensin system_Homo sapiens_hsa04614	0.45261989
94	Non-homologous end-joining_Homo sapiens_hsa03450	0.44474080
95	Fatty acid metabolism_Homo sapiens_hsa01212	0.43761083
96	Propanoate metabolism_Homo sapiens_hsa00640	0.42866769
97	Pancreatic secretion_Homo sapiens_hsa04972	0.41905855
98	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.40925394
99	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.40508272
100	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.40465072

KRT18P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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