ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	8.75991747
2	folic acid-containing compound biosynthetic process (GO:0009396)	7.09942094
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.55119860
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.55119860
5	cysteine metabolic process (GO:0006534)	6.37211274
6	regulation of plasminogen activation (GO:0010755)	6.18922650
7	desmosome organization (GO:0002934)	6.09110029
8	sulfur amino acid catabolic process (GO:0000098)	5.71407470
9	L-serine metabolic process (GO:0006563)	5.69880205
10	adenosine metabolic process (GO:0046085)	5.40483255
11	pteridine-containing compound biosynthetic process (GO:0042559)	5.34119682
12	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.33152218
13	purine nucleotide salvage (GO:0032261)	5.30332339
14	negative regulation of DNA biosynthetic process (GO:2000279)	5.22444332
15	regulation of sequestering of triglyceride (GO:0010889)	5.01517760
16	white fat cell differentiation (GO:0050872)	5.00653784
17	negative regulation of telomerase activity (GO:0051974)	4.84876289
18	mitochondrial RNA metabolic process (GO:0000959)	4.82958716
19	hepatocyte apoptotic process (GO:0097284)	4.70168028
20	negative regulation of keratinocyte proliferation (GO:0010839)	4.68519724
21	regulation of oxidative phosphorylation (GO:0002082)	4.67805852
22	serine family amino acid biosynthetic process (GO:0009070)	4.62629058
23	aminoglycoside antibiotic metabolic process (GO:0030647)	4.57623939
24	ribosome biogenesis (GO:0042254)	4.44513408
25	nucleoside transmembrane transport (GO:1901642)	4.32177401
26	rRNA modification (GO:0000154)	4.31665560
27	artery smooth muscle contraction (GO:0014824)	4.27389272
28	inner ear receptor cell development (GO:0060119)	4.24181646
29	pseudouridine synthesis (GO:0001522)	4.24138772
30	folic acid-containing compound metabolic process (GO:0006760)	4.07784226
31	tetrahydrofolate metabolic process (GO:0046653)	4.01007445
32	energy homeostasis (GO:0097009)	3.98154840
33	rRNA methylation (GO:0031167)	3.92438438
34	serine family amino acid catabolic process (GO:0009071)	3.91902888
35	folic acid transport (GO:0015884)	3.88029153
36	CENP-A containing nucleosome assembly (GO:0034080)	3.86995794
37	microtubule nucleation (GO:0007020)	3.85222961
38	galactose catabolic process (GO:0019388)	3.82290987
39	alternative mRNA splicing, via spliceosome (GO:0000380)	3.82164958
40	glycoside metabolic process (GO:0016137)	3.77104718
41	ATP hydrolysis coupled proton transport (GO:0015991)	3.75113946
42	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.75113946
43	basic amino acid transport (GO:0015802)	3.72787840
44	regulation of gonadotropin secretion (GO:0032276)	3.65807677
45	galactose metabolic process (GO:0006012)	3.62215531
46	tonic smooth muscle contraction (GO:0014820)	3.59159025
47	pteridine-containing compound metabolic process (GO:0042558)	3.58238736
48	negative regulation of catenin import into nucleus (GO:0035414)	3.56927114
49	IMP biosynthetic process (GO:0006188)	3.56861690
50	regulation of G0 to G1 transition (GO:0070316)	3.54624301
51	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.53672698
52	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.52946498
53	chromatin remodeling at centromere (GO:0031055)	3.51498575
54	nucleoside transport (GO:0015858)	3.44153430
55	protein-cofactor linkage (GO:0018065)	3.42547630
56	polyamine biosynthetic process (GO:0006596)	3.42541538
57	sulfur amino acid biosynthetic process (GO:0000097)	3.41967239
58	regulation of tight junction assembly (GO:2000810)	3.36566062
59	prostanoid biosynthetic process (GO:0046457)	3.36200574
60	prostaglandin biosynthetic process (GO:0001516)	3.36200574
61	guanosine-containing compound biosynthetic process (GO:1901070)	3.35306203
62	regulation of cellular respiration (GO:0043457)	3.31604976
63	folic acid metabolic process (GO:0046655)	3.28303274
64	regulation of telomerase activity (GO:0051972)	3.26929945
65	regulation of vitamin metabolic process (GO:0030656)	3.24640541
66	response to vitamin A (GO:0033189)	3.24632314
67	placenta development (GO:0001890)	3.22518664
68	nucleotide salvage (GO:0043173)	3.21155184
69	tRNA modification (GO:0006400)	3.20501865
70	tRNA processing (GO:0008033)	3.19580868
71	chaperone-mediated protein transport (GO:0072321)	3.14352292
72	phosphate ion homeostasis (GO:0055062)	3.12064337
73	trivalent inorganic anion homeostasis (GO:0072506)	3.12064337
74	GTP biosynthetic process (GO:0006183)	3.10881169
75	regulation of vitamin D biosynthetic process (GO:0060556)	3.10256114
76	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.07205833
77	NADH dehydrogenase complex assembly (GO:0010257)	3.07205833
78	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.07205833
79	histone exchange (GO:0043486)	3.07001418
80	interferon-gamma secretion (GO:0072643)	3.06298829
81	positive regulation of endothelial cell differentiation (GO:0045603)	3.06270552
82	water-soluble vitamin biosynthetic process (GO:0042364)	3.02960283
83	ribonucleoprotein complex biogenesis (GO:0022613)	3.01477350
84	inner mitochondrial membrane organization (GO:0007007)	2.96636190
85	polyamine metabolic process (GO:0006595)	2.95540011
86	polyketide metabolic process (GO:0030638)	2.94594158
87	doxorubicin metabolic process (GO:0044598)	2.94594158
88	daunorubicin metabolic process (GO:0044597)	2.94594158
89	negative regulation of Ras GTPase activity (GO:0034261)	2.94146597
90	serine family amino acid metabolic process (GO:0009069)	2.93838072
91	viral mRNA export from host cell nucleus (GO:0046784)	2.93448608
92	negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)	2.89817415
93	protein-chromophore linkage (GO:0018298)	2.87956098
94	primary amino compound metabolic process (GO:1901160)	2.87825279
95	heme transport (GO:0015886)	2.87583931
96	cellular component biogenesis (GO:0044085)	2.86224865
97	innervation (GO:0060384)	2.85307959
98	purine-containing compound salvage (GO:0043101)	2.84553531
99	proteasome assembly (GO:0043248)	2.84116114
100	alpha-amino acid biosynthetic process (GO:1901607)	2.83703578

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	9.66011219
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.69991040
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.83809541
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.04170108
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.90184978
6	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.72639305
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.61801270
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.61341273
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.56160821
10	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.47318415
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.35501101
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.16440119
13	AR_21909140_ChIP-Seq_LNCAP_Human	2.16294748
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.12408129
15	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.05501879
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02822885
17	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.99080878
18	ZNF263_19887448_ChIP-Seq_K562_Human	1.92595616
19	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.92191593
20	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.90593640
21	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.82612569
22	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.74039928
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.72247593
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70164308
25	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.68761202
26	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.67308173
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.65838027
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65830453
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.65034409
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.64887265
31	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.64467174
32	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.61203650
33	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.57561805
34	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.53543937
35	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.51992441
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49718794
37	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.36124709
38	KDM5A_27292631_Chip-Seq_BREAST_Human	1.35738519
39	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.35185018
40	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.34946291
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.34174317
42	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.32439245
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.29514702
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.29418290
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29169160
46	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.27178831
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26271398
48	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.24922509
49	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.24877468
50	GATA3_24758297_ChIP-Seq_MCF-7_Human	1.21706184
51	GATA4_25053715_ChIP-Seq_YYC3_Human	1.19576661
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.17811318
53	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.17793684
54	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.17091220
55	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.16382445
56	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.14289041
57	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.12086288
58	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.11067505
59	CDX2_22108803_ChIP-Seq_LS180_Human	1.11057706
60	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.03498142
61	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.03460144
62	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.03393879
63	ATF3_27146783_Chip-Seq_COLON_Human	1.03385668
64	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02927949
65	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.02469702
66	DCP1A_22483619_ChIP-Seq_HELA_Human	1.00628879
67	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	1.00559901
68	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96323694
69	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.96269792
70	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.94308831
71	TTF2_22483619_ChIP-Seq_HELA_Human	0.93817772
72	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.93292665
73	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.93150671
74	FLI1_21867929_ChIP-Seq_CD8_Mouse	0.92097788
75	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.91823079
76	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.90827592
77	TP53_22127205_ChIP-Seq_IMR90_Human	0.90194084
78	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.89872981
79	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.89215780
80	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.88789279
81	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.88377649
82	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.86515354
83	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86403808
84	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.86258609
85	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86099593
86	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.85776609
87	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.85073497
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85066072
89	STAT1_20625510_ChIP-Seq_HELA_Human	0.84662641
90	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.83261631
91	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.83045792
92	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.82082294
93	P68_20966046_ChIP-Seq_HELA_Human	0.82000463
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.80511217
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.80203734
96	CEBPB_22108803_ChIP-Seq_LS180_Human	0.79866320
97	SOX2_20726797_ChIP-Seq_SW620_Human	0.79553896
98	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.79050836
99	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.78588046
100	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.77848800

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003183_abnormal_peptide_metabolism	5.71589838
2	MP0005670_abnormal_white_adipose	5.34650157
3	MP0005360_urolithiasis	4.72072966
4	MP0001661_extended_life_span	3.78762347
5	MP0005646_abnormal_pituitary_gland	3.41981484
6	MP0003878_abnormal_ear_physiology	3.15853965
7	MP0005377_hearing/vestibular/ear_phenot	3.15853965
8	MP0003693_abnormal_embryo_hatching	3.06292052
9	MP0004147_increased_porphyrin_level	2.90720418
10	MP0003806_abnormal_nucleotide_metabolis	2.76073839
11	MP0004185_abnormal_adipocyte_glucose	2.66742061
12	MP0003186_abnormal_redox_activity	2.41000975
13	MP0003705_abnormal_hypodermis_morpholog	2.40758712
14	MP0004885_abnormal_endolymph	2.39341889
15	MP0000647_abnormal_sebaceous_gland	2.26384802
16	MP0002160_abnormal_reproductive_system	2.18520781
17	MP0001764_abnormal_homeostasis	2.14813079
18	MP0000013_abnormal_adipose_tissue	2.11992300
19	MP0000516_abnormal_urinary_system	2.10255670
20	MP0005367_renal/urinary_system_phenotyp	2.10255670
21	MP0008995_early_reproductive_senescence	2.10006421
22	MP0008872_abnormal_physiological_respon	2.08381483
23	MP0002736_abnormal_nociception_after	2.04371730
24	MP0002938_white_spotting	1.99173538
25	MP0002396_abnormal_hematopoietic_system	1.87534685
26	MP0002163_abnormal_gland_morphology	1.86156474
27	MP0005332_abnormal_amino_acid	1.70276517
28	MP0000566_synostosis	1.69260491
29	MP0009379_abnormal_foot_pigmentation	1.63765878
30	MP0004264_abnormal_extraembryonic_tissu	1.62886243
31	MP0003724_increased_susceptibility_to	1.62617320
32	MP0006292_abnormal_olfactory_placode	1.55792463
33	MP0004957_abnormal_blastocyst_morpholog	1.46641633
34	MP0003315_abnormal_perineum_morphology	1.35650791
35	MP0008875_abnormal_xenobiotic_pharmacok	1.35135051
36	MP0004019_abnormal_vitamin_homeostasis	1.29363084
37	MP0005389_reproductive_system_phenotype	1.27869900
38	MP0000613_abnormal_salivary_gland	1.26107349
39	MP0001666_abnormal_nutrient_absorption	1.25469174
40	MP0005085_abnormal_gallbladder_physiolo	1.19445483
41	MP0008058_abnormal_DNA_repair	1.19039779
42	MP0006035_abnormal_mitochondrial_morpho	1.18798210
43	MP0000467_abnormal_esophagus_morphology	1.17265677
44	MP0005636_abnormal_mineral_homeostasis	1.12125095
45	MP0002837_dystrophic_cardiac_calcinosis	1.12063793
46	MP0001968_abnormal_touch/_nociception	1.12051673
47	MP0003786_premature_aging	1.08559709
48	MP0003718_maternal_effect	1.04509315
49	MP0001756_abnormal_urination	1.00340345
50	MP0003936_abnormal_reproductive_system	0.98368838
51	MP0002210_abnormal_sex_determination	0.97229786
52	MP0002098_abnormal_vibrissa_morphology	0.95304584
53	MP0000534_abnormal_ureter_morphology	0.93262271
54	MP0002735_abnormal_chemical_nociception	0.92686558
55	MP0009643_abnormal_urine_homeostasis	0.92307498
56	MP0000627_abnormal_mammary_gland	0.91710501
57	MP0005319_abnormal_enzyme/_coenzyme	0.90730393
58	MP0000653_abnormal_sex_gland	0.90627007
59	MP0005501_abnormal_skin_physiology	0.89772293
60	MP0001145_abnormal_male_reproductive	0.89500242
61	MP0002138_abnormal_hepatobiliary_system	0.85148626
62	MP0003638_abnormal_response/metabolism_	0.84306524
63	MP0004130_abnormal_muscle_cell	0.83171610
64	MP0002277_abnormal_respiratory_mucosa	0.82644591
65	MP0003111_abnormal_nucleus_morphology	0.81011130
66	MP0002796_impaired_skin_barrier	0.80128815
67	MP0005220_abnormal_exocrine_pancreas	0.79776792
68	MP0002132_abnormal_respiratory_system	0.78901781
69	MP0002139_abnormal_hepatobiliary_system	0.77198309
70	MP0005376_homeostasis/metabolism_phenot	0.77185975
71	MP0003252_abnormal_bile_duct	0.76817424
72	MP0005410_abnormal_fertilization	0.74976159
73	MP0005076_abnormal_cell_differentiation	0.74801330
74	MP0005365_abnormal_bile_salt	0.72572399
75	MP0009765_abnormal_xenobiotic_induced	0.72425642
76	MP0010771_integument_phenotype	0.71968852
77	MP0001944_abnormal_pancreas_morphology	0.71128107
78	MP0002095_abnormal_skin_pigmentation	0.70771396
79	MP0001293_anophthalmia	0.70461555
80	MP0004233_abnormal_muscle_weight	0.70368919
81	MP0000026_abnormal_inner_ear	0.68756327
82	MP0001119_abnormal_female_reproductive	0.68507488
83	MP0003959_abnormal_lean_body	0.67983315
84	MP0002136_abnormal_kidney_physiology	0.66582798
85	MP0005083_abnormal_biliary_tract	0.66269393
86	MP0001440_abnormal_grooming_behavior	0.65695304
87	MP0000371_diluted_coat_color	0.64659045
88	MP0004043_abnormal_pH_regulation	0.64175355
89	MP0002697_abnormal_eye_size	0.63496132
90	MP0002295_abnormal_pulmonary_circulatio	0.62814218
91	MP0001929_abnormal_gametogenesis	0.62360349
92	MP0003942_abnormal_urinary_system	0.62005576
93	MP0010030_abnormal_orbit_morphology	0.61444318
94	MP0000383_abnormal_hair_follicle	0.60998994
95	MP0010094_abnormal_chromosome_stability	0.60060228
96	MP0002876_abnormal_thyroid_physiology	0.59982194
97	MP0005408_hypopigmentation	0.58217731
98	MP0000631_abnormal_neuroendocrine_gland	0.57820133
99	MP0001919_abnormal_reproductive_system	0.57775259
100	MP0003698_abnormal_male_reproductive	0.57651826

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.94405453
2	Hyperalaninemia (HP:0003348)	7.94405453
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.94405453
4	Esophageal varix (HP:0002040)	5.14296797
5	Constricted visual fields (HP:0001133)	4.75889942
6	Congenital sensorineural hearing impairment (HP:0008527)	4.34167031
7	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.02216294
8	Oligomenorrhea (HP:0000876)	3.94591781
9	Birth length less than 3rd percentile (HP:0003561)	3.92915998
10	Stenosis of the external auditory canal (HP:0000402)	3.88764428
11	Abnormality of serum amino acid levels (HP:0003112)	3.72536557
12	Carpal bone hypoplasia (HP:0001498)	3.66312673
13	Conjugated hyperbilirubinemia (HP:0002908)	3.65317237
14	Abnormal umbilical cord blood vessels (HP:0011403)	3.64238320
15	Single umbilical artery (HP:0001195)	3.64238320
16	Abnormality of the fetal cardiovascular system (HP:0010948)	3.64238320
17	Reduced subcutaneous adipose tissue (HP:0003758)	3.57632714
18	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	3.50189054
19	Spontaneous hematomas (HP:0007420)	3.38200637
20	Hyperglycinemia (HP:0002154)	3.18192131
21	Anorexia (HP:0002039)	3.14810632
22	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.14771723
23	Homocystinuria (HP:0002156)	3.10479870
24	Abnormality of homocysteine metabolism (HP:0010919)	3.10479870
25	Conjunctival telangiectasia (HP:0000524)	2.94847344
26	Insulin-resistant diabetes mellitus (HP:0000831)	2.94064585
27	Abnormality of the umbilical cord (HP:0010881)	2.88391662
28	White forelock (HP:0002211)	2.87232276
29	Ileus (HP:0002595)	2.82421175
30	Hyperglycemia (HP:0003074)	2.78485495
31	Long clavicles (HP:0000890)	2.77917024
32	Chorioretinal atrophy (HP:0000533)	2.74767162
33	Maternal diabetes (HP:0009800)	2.72142309
34	J-shaped sella turcica (HP:0002680)	2.68989434
35	Hypoplastic pelvis (HP:0008839)	2.55902404
36	Poor speech (HP:0002465)	2.55216908
37	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.51352084
38	Short 1st metacarpal (HP:0010034)	2.51352084
39	Paralysis (HP:0003470)	2.50950561
40	Pigmentary retinal degeneration (HP:0001146)	2.46809980
41	Cavernous hemangioma (HP:0001048)	2.45678534
42	Patchy hypopigmentation of hair (HP:0011365)	2.45073795
43	Myocardial infarction (HP:0001658)	2.44062688
44	Proximal tubulopathy (HP:0000114)	2.43900792
45	Hypoalphalipoproteinemia (HP:0003233)	2.40464737
46	Hypomagnesemia (HP:0002917)	2.38201124
47	Generalized aminoaciduria (HP:0002909)	2.35510426
48	Abnormality of magnesium homeostasis (HP:0004921)	2.32449987
49	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.32405907
50	Decreased subcutaneous fat (HP:0001002)	2.31450896
51	Tetany (HP:0001281)	2.30215374
52	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.24757220
53	Abnormality of the 1st metacarpal (HP:0010009)	2.22499646
54	Renal tubular acidosis (HP:0001947)	2.21736598
55	Spontaneous abortion (HP:0005268)	2.19299099
56	Increased purine levels (HP:0004368)	2.18832683
57	Hyperuricemia (HP:0002149)	2.18832683
58	Pendular nystagmus (HP:0012043)	2.17499959
59	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.13479473
60	Toxemia of pregnancy (HP:0100603)	2.11970473
61	Reticulocytopenia (HP:0001896)	2.11226023
62	Abnormalities of placenta or umbilical cord (HP:0001194)	2.11100920
63	Abnormality of subcutaneous fat tissue (HP:0001001)	2.06243748
64	Hypoplastic heart (HP:0001961)	2.05898414
65	Abnormality of cochlea (HP:0000375)	2.05758793
66	Diastasis recti (HP:0001540)	2.01038860
67	Abnormality of glycine metabolism (HP:0010895)	2.00273661
68	Abnormality of serine family amino acid metabolism (HP:0010894)	2.00273661
69	Action tremor (HP:0002345)	1.98975005
70	Flat acetabular roof (HP:0003180)	1.96449912
71	Chromsome breakage (HP:0040012)	1.94352056
72	Metabolic acidosis (HP:0001942)	1.93743003
73	Visceral angiomatosis (HP:0100761)	1.88453873
74	Dyskinesia (HP:0100660)	1.85172230
75	Arteriovenous malformation (HP:0100026)	1.85124463
76	Arterial thrombosis (HP:0004420)	1.84877708
77	Widely patent fontanelles and sutures (HP:0004492)	1.84462907
78	Thrombophlebitis (HP:0004418)	1.81960334
79	Amelogenesis imperfecta (HP:0000705)	1.81358032
80	Hypoplastic left heart (HP:0004383)	1.80347819
81	Nausea (HP:0002018)	1.79487417
82	Megaloblastic anemia (HP:0001889)	1.78789111
83	Increased serum lactate (HP:0002151)	1.78247369
84	Biconcave vertebral bodies (HP:0004586)	1.78175186
85	Pulmonary embolism (HP:0002204)	1.77960394
86	Premature graying of hair (HP:0002216)	1.76603295
87	Cortical visual impairment (HP:0100704)	1.75563475
88	Fused cervical vertebrae (HP:0002949)	1.73977652
89	Myopathic facies (HP:0002058)	1.73491712
90	Adrenal hypoplasia (HP:0000835)	1.73000511
91	Cone-rod dystrophy (HP:0000548)	1.72901820
92	Heterochromia iridis (HP:0001100)	1.72739504
93	Absent thumb (HP:0009777)	1.72051176
94	Lactic acidosis (HP:0003128)	1.71238245
95	Bilateral sensorineural hearing impairment (HP:0008619)	1.70085629
96	Attenuation of retinal blood vessels (HP:0007843)	1.69204126
97	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.67852010
98	Abnormality of the carotid arteries (HP:0005344)	1.67607594
99	Micronodular cirrhosis (HP:0001413)	1.66471781
100	Portal hypertension (HP:0001409)	1.64037277

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RPS6KB2	4.35190927
2	MAP2K3	3.74113782
3	ACVR1B	3.27754591
4	EPHA2	3.14715550
5	WNK4	3.07559381
6	MAP3K3	2.87145598
7	STK39	2.86723715
8	OXSR1	2.85532496
9	MAP3K11	2.73439097
10	CDK9	2.72115050
11	STK10	2.17895282
12	EIF2AK1	2.16545924
13	MAP3K12	2.07163863
14	GRK5	1.97859104
15	FGR	1.89208018
16	GRK7	1.82233457
17	JAK3	1.79988896
18	CDC7	1.78499637
19	PBK	1.76088980
20	TGFBR2	1.68688533
21	GRK6	1.68598866
22	ADRBK1	1.66403343
23	LMTK2	1.65581543
24	VRK2	1.58658452
25	MAP3K13	1.49660872
26	PIK3CA	1.46835432
27	PDK2	1.45824662
28	MST4	1.44245522
29	MAP2K1	1.40933188
30	MOS	1.36939647
31	MAP4K2	1.35178569
32	MAP4K1	1.27476762
33	CDK19	1.26917770
34	AURKA	1.24876788
35	PRKCI	1.16109070
36	NEK1	1.15630738
37	PLK2	1.12123124
38	EPHB2	1.08639741
39	NME2	1.08086495
40	PKN2	1.03330188
41	MAP3K6	0.95564746
42	CAMK2B	0.94781422
43	NEK6	0.93851456
44	NTRK3	0.92518409
45	CAMK2D	0.91123002
46	CAMK2G	0.90756552
47	NTRK2	0.83245039
48	PHKG2	0.83237984
49	PHKG1	0.83237984
50	GRK1	0.81947375
51	EIF2AK3	0.78775013
52	MAP3K2	0.77466874
53	DYRK2	0.76958380
54	EIF2AK2	0.76544640
55	MAP2K4	0.73268786
56	CSNK1A1	0.72447934
57	CAMK1	0.71658428
58	STK16	0.71216373
59	SGK223	0.70316131
60	SGK494	0.70316131
61	BUB1	0.67326942
62	MAP2K6	0.67190516
63	PLK4	0.66717652
64	AURKB	0.65244237
65	ERBB4	0.64940139
66	AKT2	0.64867001
67	FRK	0.64567342
68	PLK1	0.63535053
69	NME1	0.61577061
70	DAPK3	0.60190902
71	BCKDK	0.60069682
72	PRKCD	0.58677588
73	PAK4	0.58297383
74	MAP2K7	0.57611641
75	MAP3K7	0.56463088
76	CHEK2	0.56413020
77	MST1R	0.55058434
78	PIM1	0.51871711
79	MATK	0.50816568
80	IRAK2	0.49628768
81	MAPKAPK2	0.47762729
82	PRKG2	0.45662463
83	FLT3	0.42236118
84	MAP3K8	0.39043092
85	MAP3K1	0.38374131
86	PRKCE	0.38142226
87	CDK7	0.38059710
88	PAK1	0.37425437
89	NUAK1	0.35557683
90	ABL2	0.35448808
91	EGFR	0.35247654
92	PRKCQ	0.34462700
93	MAP2K2	0.33592942
94	PTK6	0.33206042
95	CCNB1	0.32885219
96	AKT3	0.32715597
97	PLK3	0.32093473
98	SMG1	0.28428869
99	SGK1	0.28074512
100	TLK1	0.26198472

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	4.57198995
2	Collecting duct acid secretion_Homo sapiens_hsa04966	4.36277926
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.68852397
4	Proteasome_Homo sapiens_hsa03050	2.65665980
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.56888839
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.49645251
7	Arginine biosynthesis_Homo sapiens_hsa00220	2.45718912
8	Sulfur metabolism_Homo sapiens_hsa00920	2.37812679
9	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.36885515
10	Vibrio cholerae infection_Homo sapiens_hsa05110	2.32269759
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.31676583
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.26757415
13	Ribosome_Homo sapiens_hsa03010	2.26136558
14	Galactose metabolism_Homo sapiens_hsa00052	2.09129322
15	Oxidative phosphorylation_Homo sapiens_hsa00190	2.03374976
16	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.00733926
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.78937681
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.78423942
19	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.70026217
20	Sulfur relay system_Homo sapiens_hsa04122	1.69461793
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.56316631
22	DNA replication_Homo sapiens_hsa03030	1.53211938
23	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.41786332
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.40405839
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.37417935
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.34962447
27	Fat digestion and absorption_Homo sapiens_hsa04975	1.34754382
28	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.33665045
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.33410232
30	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.32846242
31	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.29027142
32	RNA transport_Homo sapiens_hsa03013	1.22890972
33	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22838584
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.22682170
35	Folate biosynthesis_Homo sapiens_hsa00790	1.19292364
36	Retinol metabolism_Homo sapiens_hsa00830	1.18827719
37	RNA degradation_Homo sapiens_hsa03018	1.16772308
38	Chemical carcinogenesis_Homo sapiens_hsa05204	1.14506249
39	Glutathione metabolism_Homo sapiens_hsa00480	1.12824878
40	Basal transcription factors_Homo sapiens_hsa03022	1.12003613
41	Base excision repair_Homo sapiens_hsa03410	1.11952815
42	Non-homologous end-joining_Homo sapiens_hsa03450	1.11587129
43	Nucleotide excision repair_Homo sapiens_hsa03420	1.09135746
44	Spliceosome_Homo sapiens_hsa03040	1.06988398
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04901602
46	Arginine and proline metabolism_Homo sapiens_hsa00330	0.91771103
47	Parkinsons disease_Homo sapiens_hsa05012	0.91588932
48	Morphine addiction_Homo sapiens_hsa05032	0.90531560
49	Homologous recombination_Homo sapiens_hsa03440	0.89899452
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.89661140
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.89056104
52	Pentose phosphate pathway_Homo sapiens_hsa00030	0.88268013
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.87467692
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85886642
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.85132592
56	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.83594755
57	Carbon metabolism_Homo sapiens_hsa01200	0.83435408
58	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83224964
59	Ether lipid metabolism_Homo sapiens_hsa00565	0.82535474
60	GABAergic synapse_Homo sapiens_hsa04727	0.78405765
61	RNA polymerase_Homo sapiens_hsa03020	0.76322384
62	Peroxisome_Homo sapiens_hsa04146	0.76046020
63	Metabolic pathways_Homo sapiens_hsa01100	0.75659315
64	Taste transduction_Homo sapiens_hsa04742	0.73483273
65	Huntingtons disease_Homo sapiens_hsa05016	0.72580830
66	Thyroid cancer_Homo sapiens_hsa05216	0.70493611
67	mRNA surveillance pathway_Homo sapiens_hsa03015	0.65557060
68	Purine metabolism_Homo sapiens_hsa00230	0.65103340
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65074356
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.63558065
71	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.62035908
72	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.60018581
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59421031
74	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58995185
75	Alzheimers disease_Homo sapiens_hsa05010	0.58210961
76	Tryptophan metabolism_Homo sapiens_hsa00380	0.57328243
77	Pancreatic secretion_Homo sapiens_hsa04972	0.56212026
78	Bile secretion_Homo sapiens_hsa04976	0.54348015
79	Olfactory transduction_Homo sapiens_hsa04740	0.51407908
80	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49871542
81	Phenylalanine metabolism_Homo sapiens_hsa00360	0.48849443
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.48393694
83	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.47746816
84	Nicotine addiction_Homo sapiens_hsa05033	0.47672671
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.45879071
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43982331
87	Steroid biosynthesis_Homo sapiens_hsa00100	0.40328688
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.36712218
89	Caffeine metabolism_Homo sapiens_hsa00232	0.36246413
90	Histidine metabolism_Homo sapiens_hsa00340	0.35991789
91	Regulation of autophagy_Homo sapiens_hsa04140	0.35392959
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.33904900
93	Linoleic acid metabolism_Homo sapiens_hsa00591	0.33686682
94	Pyruvate metabolism_Homo sapiens_hsa00620	0.31996405
95	Alcoholism_Homo sapiens_hsa05034	0.25720397
96	Fatty acid elongation_Homo sapiens_hsa00062	0.25657259
97	Renin-angiotensin system_Homo sapiens_hsa04614	0.25285999
98	Mineral absorption_Homo sapiens_hsa04978	0.22828076
99	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.22390797
100	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.22370133

KRT18P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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