ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	folic acid-containing compound biosynthetic process (GO:0009396)	6.35711434
2	homocysteine metabolic process (GO:0050667)	6.30651855
3	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.21275510
4	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.21275510
5	sulfur amino acid catabolic process (GO:0000098)	5.74071255
6	pteridine-containing compound biosynthetic process (GO:0042559)	5.33441875
7	cysteine metabolic process (GO:0006534)	5.29770690
8	purine nucleotide salvage (GO:0032261)	5.26177589
9	regulation of plasminogen activation (GO:0010755)	5.14728323
10	mitochondrial RNA metabolic process (GO:0000959)	4.92781987
11	IMP biosynthetic process (GO:0006188)	4.80020779
12	proteasome assembly (GO:0043248)	4.61791250
13	rRNA modification (GO:0000154)	4.58514923
14	ribosome biogenesis (GO:0042254)	4.56792366
15	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.56643035
16	L-serine metabolic process (GO:0006563)	4.52133954
17	IMP metabolic process (GO:0046040)	4.18922454
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.18142169
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.18142169
20	NADH dehydrogenase complex assembly (GO:0010257)	4.18142169
21	pseudouridine synthesis (GO:0001522)	4.17916899
22	adenosine metabolic process (GO:0046085)	4.17884465
23	desmosome organization (GO:0002934)	4.12557864
24	rRNA methylation (GO:0031167)	4.12265230
25	ribonucleoprotein complex biogenesis (GO:0022613)	4.01546844
26	galactose catabolic process (GO:0019388)	3.92622343
27	ATP synthesis coupled proton transport (GO:0015986)	3.92481905
28	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.92481905
29	nucleoside transmembrane transport (GO:1901642)	3.90229147
30	chaperone-mediated protein transport (GO:0072321)	3.88808608
31	alternative mRNA splicing, via spliceosome (GO:0000380)	3.81544137
32	white fat cell differentiation (GO:0050872)	3.78830994
33	cellular component biogenesis (GO:0044085)	3.78696105
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.77484919
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.77430223
36	tetrahydrofolate metabolic process (GO:0046653)	3.75653676
37	protein complex biogenesis (GO:0070271)	3.72466648
38	transcription from mitochondrial promoter (GO:0006390)	3.70230898
39	serine family amino acid biosynthetic process (GO:0009070)	3.66218589
40	ribosomal small subunit biogenesis (GO:0042274)	3.65395007
41	folic acid-containing compound metabolic process (GO:0006760)	3.58963583
42	guanosine-containing compound biosynthetic process (GO:1901070)	3.57733834
43	regulation of cellular amino acid metabolic process (GO:0006521)	3.57451381
44	inner mitochondrial membrane organization (GO:0007007)	3.56276125
45	ribosomal small subunit assembly (GO:0000028)	3.53356556
46	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.50097315
47	protein-cofactor linkage (GO:0018065)	3.48779830
48	negative regulation of DNA biosynthetic process (GO:2000279)	3.43405257
49	pteridine-containing compound metabolic process (GO:0042558)	3.42514313
50	regulation of gonadotropin secretion (GO:0032276)	3.42358538
51	CENP-A containing nucleosome assembly (GO:0034080)	3.40718679
52	respiratory electron transport chain (GO:0022904)	3.39009225
53	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.38068597
54	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.34525571
55	viral transcription (GO:0019083)	3.32120226
56	ncRNA 3-end processing (GO:0043628)	3.29735504
57	galactose metabolic process (GO:0006012)	3.29540175
58	electron transport chain (GO:0022900)	3.28733671
59	GTP biosynthetic process (GO:0006183)	3.26698651
60	ribosomal large subunit biogenesis (GO:0042273)	3.24871763
61	nucleotide salvage (GO:0043173)	3.22948800
62	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.21261602
63	sulfur amino acid biosynthetic process (GO:0000097)	3.20864421
64	positive regulation of endothelial cell differentiation (GO:0045603)	3.18203668
65	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.17996454
66	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.16799544
67	translational termination (GO:0006415)	3.16601472
68	rRNA processing (GO:0006364)	3.15591788
69	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.13165251
70	chromatin remodeling at centromere (GO:0031055)	3.11496483
71	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.09172934
72	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.09172934
73	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.08749065
74	negative regulation of ligase activity (GO:0051352)	3.08749065
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.08498313
76	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.08498313
77	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.07404593
78	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.07404593
79	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.07404593
80	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.07147517
81	ATP hydrolysis coupled proton transport (GO:0015991)	3.04610662
82	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.04610662
83	cotranslational protein targeting to membrane (GO:0006613)	3.04577569
84	tRNA processing (GO:0008033)	3.03379258
85	protein targeting to mitochondrion (GO:0006626)	3.03027441
86	protein-chromophore linkage (GO:0018298)	3.02762687
87	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.02013613
88	protein targeting to ER (GO:0045047)	3.00062871
89	spliceosomal snRNP assembly (GO:0000387)	2.97657152
90	rRNA metabolic process (GO:0016072)	2.96943731
91	inner ear receptor cell development (GO:0060119)	2.96683042
92	serine family amino acid catabolic process (GO:0009071)	2.94516378
93	DNA replication-dependent nucleosome organization (GO:0034723)	2.93989370
94	DNA replication-dependent nucleosome assembly (GO:0006335)	2.93989370
95	translational elongation (GO:0006414)	2.93218597
96	UTP biosynthetic process (GO:0006228)	2.93147479
97	polyamine biosynthetic process (GO:0006596)	2.92244538
98	folic acid metabolic process (GO:0046655)	2.91483821
99	water-soluble vitamin biosynthetic process (GO:0042364)	2.87939509
100	protein localization to endoplasmic reticulum (GO:0070972)	2.87196025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.80889581
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.67367093
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.11411580
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.06703856
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.88386823
6	E2F7_22180533_ChIP-Seq_HELA_Human	3.79800213
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.63436445
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.55416246
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.26599044
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.10450651
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.02825413
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.99757420
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.98415606
14	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.95531109
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.86092543
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.85791318
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.71245416
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.70211499
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.57441762
20	AR_21909140_ChIP-Seq_LNCAP_Human	2.55790949
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.51385725
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.43186552
23	XRN2_22483619_ChIP-Seq_HELA_Human	2.25831995
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25360467
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.20603960
26	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.14819115
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.12913858
28	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.11676124
29	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.99880593
30	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95853481
31	GABP_19822575_ChIP-Seq_HepG2_Human	1.90679070
32	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.89700854
33	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87774915
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.85744801
35	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.84370941
36	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.83920980
37	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.79368264
38	VDR_23849224_ChIP-Seq_CD4+_Human	1.79341713
39	DCP1A_22483619_ChIP-Seq_HELA_Human	1.74018657
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.73240573
41	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.66500260
42	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.61741921
43	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.57325208
44	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.56777049
45	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.54870852
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.51668698
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.50215260
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.44578547
49	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.39551799
50	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.38381501
51	TTF2_22483619_ChIP-Seq_HELA_Human	1.38248539
52	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.37239858
53	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.35870537
54	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.33779888
55	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.29996562
56	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.24164303
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23482578
58	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.23221454
59	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.19551915
60	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.18980036
61	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.17935924
62	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.17251357
63	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15262334
64	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.14580517
65	ZNF263_19887448_ChIP-Seq_K562_Human	1.14133469
66	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.10262507
67	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.09405924
68	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.08866272
69	KDM5A_27292631_Chip-Seq_BREAST_Human	1.08124785
70	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06358370
71	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.05989012
72	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	1.04548053
73	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03711186
74	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01808751
75	TBX5_21415370_ChIP-Seq_HL-1_Mouse	1.00194138
76	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.96575582
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.96536638
78	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96154079
79	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.95526115
80	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.93383586
81	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.92927905
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.89936734
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.89798475
84	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.89691845
85	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.86572916
86	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.86051492
87	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.85059290
88	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.84874696
89	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.82548326
90	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.81857346
91	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.81536755
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.81244216
93	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.80682273
94	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.79129614
95	P68_20966046_ChIP-Seq_HELA_Human	0.77018411
96	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.74168129
97	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.73205809
98	GATA4_25053715_ChIP-Seq_YYC3_Human	0.72963508
99	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.72852474
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.72262411

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	5.92474047
2	MP0005360_urolithiasis	5.07604630
3	MP0002938_white_spotting	4.05163134
4	MP0005670_abnormal_white_adipose	3.75565912
5	MP0008875_abnormal_xenobiotic_pharmacok	3.18786074
6	MP0001661_extended_life_span	3.11468820
7	MP0005646_abnormal_pituitary_gland	3.01930419
8	MP0003186_abnormal_redox_activity	2.89790492
9	MP0004147_increased_porphyrin_level	2.68115880
10	MP0001764_abnormal_homeostasis	2.63628797
11	MP0008995_early_reproductive_senescence	2.52303406
12	MP0003693_abnormal_embryo_hatching	2.47318299
13	MP0002638_abnormal_pupillary_reflex	2.44999027
14	MP0002736_abnormal_nociception_after	2.33965480
15	MP0003123_paternal_imprinting	2.23081527
16	MP0005332_abnormal_amino_acid	2.22020928
17	MP0004957_abnormal_blastocyst_morpholog	2.18297263
18	MP0003183_abnormal_peptide_metabolism	2.15573851
19	MP0000013_abnormal_adipose_tissue	2.07526323
20	MP0003111_abnormal_nucleus_morphology	1.93306693
21	MP0009697_abnormal_copulation	1.92296540
22	MP0000647_abnormal_sebaceous_gland	1.85276229
23	MP0008872_abnormal_physiological_respon	1.78177326
24	MP0004185_abnormal_adipocyte_glucose	1.76399899
25	MP0002139_abnormal_hepatobiliary_system	1.74972975
26	MP0010094_abnormal_chromosome_stability	1.73817209
27	MP0003077_abnormal_cell_cycle	1.73323314
28	MP0002160_abnormal_reproductive_system	1.71301517
29	MP0000516_abnormal_urinary_system	1.70916202
30	MP0005367_renal/urinary_system_phenotyp	1.70916202
31	MP0008058_abnormal_DNA_repair	1.65786704
32	MP0003705_abnormal_hypodermis_morpholog	1.53391218
33	MP0003786_premature_aging	1.51378643
34	MP0005085_abnormal_gallbladder_physiolo	1.46112825
35	MP0002282_abnormal_trachea_morphology	1.39263038
36	MP0003718_maternal_effect	1.31139037
37	MP0000566_synostosis	1.27788283
38	MP0005319_abnormal_enzyme/_coenzyme	1.20805178
39	MP0003878_abnormal_ear_physiology	1.20669690
40	MP0005377_hearing/vestibular/ear_phenot	1.20669690
41	MP0008932_abnormal_embryonic_tissue	1.17463318
42	MP0006036_abnormal_mitochondrial_physio	1.16283019
43	MP0001968_abnormal_touch/_nociception	1.11493304
44	MP0005636_abnormal_mineral_homeostasis	1.09760493
45	MP0002735_abnormal_chemical_nociception	1.07847281
46	MP0009643_abnormal_urine_homeostasis	1.06863953
47	MP0004019_abnormal_vitamin_homeostasis	1.05666017
48	MP0005365_abnormal_bile_salt	1.03222957
49	MP0003252_abnormal_bile_duct	1.02112746
50	MP0000534_abnormal_ureter_morphology	0.99093296
51	MP0002132_abnormal_respiratory_system	0.98677178
52	MP0005389_reproductive_system_phenotype	0.98164894
53	MP0010234_abnormal_vibrissa_follicle	0.96276898
54	MP0003941_abnormal_skin_development	0.94406930
55	MP0002396_abnormal_hematopoietic_system	0.93015410
56	MP0003315_abnormal_perineum_morphology	0.92227829
57	MP0001730_embryonic_growth_arrest	0.91006269
58	MP0002210_abnormal_sex_determination	0.87525883
59	MP0001944_abnormal_pancreas_morphology	0.86086904
60	MP0001529_abnormal_vocalization	0.84029120
61	MP0003890_abnormal_embryonic-extraembry	0.83134404
62	MP0001756_abnormal_urination	0.82701992
63	MP0002098_abnormal_vibrissa_morphology	0.80344654
64	MP0005408_hypopigmentation	0.79757555
65	MP0002111_abnormal_tail_morphology	0.79502969
66	MP0005410_abnormal_fertilization	0.78993442
67	MP0000653_abnormal_sex_gland	0.77889561
68	MP0001905_abnormal_dopamine_level	0.77816510
69	MP0000579_abnormal_nail_morphology	0.77344410
70	MP0005220_abnormal_exocrine_pancreas	0.77004456
71	MP0000538_abnormal_urinary_bladder	0.75178853
72	MP0002295_abnormal_pulmonary_circulatio	0.74328379
73	MP0001145_abnormal_male_reproductive	0.72926480
74	MP0005376_homeostasis/metabolism_phenot	0.72899610
75	MP0001340_abnormal_eyelid_morphology	0.72127501
76	MP0002697_abnormal_eye_size	0.72023478
77	MP0001929_abnormal_gametogenesis	0.71949776
78	MP0003942_abnormal_urinary_system	0.70846673
79	MP0006072_abnormal_retinal_apoptosis	0.70670615
80	MP0010030_abnormal_orbit_morphology	0.69646805
81	MP0002095_abnormal_skin_pigmentation	0.67770046
82	MP0001919_abnormal_reproductive_system	0.66996813
83	MP0004133_heterotaxia	0.66452122
84	MP0000358_abnormal_cell_content/	0.66054160
85	MP0001697_abnormal_embryo_size	0.66006242
86	MP0000026_abnormal_inner_ear	0.64461197
87	MP0003638_abnormal_response/metabolism_	0.63948505
88	MP0001216_abnormal_epidermal_layer	0.62903583
89	MP0003724_increased_susceptibility_to	0.62031549
90	MP0000678_abnormal_parathyroid_gland	0.61495653
91	MP0009765_abnormal_xenobiotic_induced	0.60719137
92	MP0006035_abnormal_mitochondrial_morpho	0.60350488
93	MP0000467_abnormal_esophagus_morphology	0.60175219
94	MP0008873_increased_physiological_sensi	0.59505652
95	MP0000490_abnormal_crypts_of	0.59283937
96	MP0003937_abnormal_limbs/digits/tail_de	0.58045450
97	MP0005584_abnormal_enzyme/coenzyme_acti	0.57504023
98	MP0002080_prenatal_lethality	0.57493914
99	MP0005253_abnormal_eye_physiology	0.57409314
100	MP0001119_abnormal_female_reproductive	0.57272974

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.64696528
2	Abnormality of alanine metabolism (HP:0010916)	7.64696528
3	Hyperalaninemia (HP:0003348)	7.64696528
4	Acute necrotizing encephalopathy (HP:0006965)	4.62882357
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.36322140
6	Constricted visual fields (HP:0001133)	4.23589230
7	Acute encephalopathy (HP:0006846)	4.21391555
8	Abnormality of serum amino acid levels (HP:0003112)	4.19183625
9	Abnormality of the fetal cardiovascular system (HP:0010948)	4.06021679
10	Abnormal umbilical cord blood vessels (HP:0011403)	4.06021679
11	Single umbilical artery (HP:0001195)	4.06021679
12	Mitochondrial inheritance (HP:0001427)	3.93285295
13	Birth length less than 3rd percentile (HP:0003561)	3.75769197
14	Progressive macrocephaly (HP:0004481)	3.71643649
15	Increased CSF lactate (HP:0002490)	3.53565079
16	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.46791465
17	Esophageal varix (HP:0002040)	3.46147328
18	Cerebral edema (HP:0002181)	3.41415460
19	Patchy hypopigmentation of hair (HP:0011365)	3.40772636
20	Homocystinuria (HP:0002156)	3.38190899
21	Abnormality of homocysteine metabolism (HP:0010919)	3.38190899
22	Generalized aminoaciduria (HP:0002909)	3.37984844
23	Increased hepatocellular lipid droplets (HP:0006565)	3.37115285
24	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.30560119
25	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.30547686
26	White forelock (HP:0002211)	3.29519242
27	Lipid accumulation in hepatocytes (HP:0006561)	3.21191435
28	Abnormality of methionine metabolism (HP:0010901)	3.13424078
29	Abnormality of the umbilical cord (HP:0010881)	3.05213638
30	Congenital sensorineural hearing impairment (HP:0008527)	3.03250910
31	Lactic acidosis (HP:0003128)	3.01829688
32	Megaloblastic anemia (HP:0001889)	2.98195262
33	Increased serum lactate (HP:0002151)	2.87325589
34	Hepatocellular necrosis (HP:0001404)	2.86280412
35	Hyperglycinemia (HP:0002154)	2.84623174
36	Renal Fanconi syndrome (HP:0001994)	2.83828240
37	Hepatic necrosis (HP:0002605)	2.81637012
38	Increased serum pyruvate (HP:0003542)	2.78857142
39	Nausea (HP:0002018)	2.72426908
40	Hyperphosphaturia (HP:0003109)	2.69020899
41	Macrocytic anemia (HP:0001972)	2.68709620
42	3-Methylglutaconic aciduria (HP:0003535)	2.66618395
43	Stenosis of the external auditory canal (HP:0000402)	2.58572454
44	Abnormality of glycolysis (HP:0004366)	2.51784423
45	Glycosuria (HP:0003076)	2.51405546
46	Abnormality of urine glucose concentration (HP:0011016)	2.51405546
47	Anorexia (HP:0002039)	2.49097213
48	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.47778120
49	Myocardial infarction (HP:0001658)	2.47701982
50	Conjugated hyperbilirubinemia (HP:0002908)	2.47027615
51	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.43832058
52	Lethargy (HP:0001254)	2.40736444
53	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.39374016
54	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.39374016
55	Exercise intolerance (HP:0003546)	2.37662524
56	Decreased subcutaneous fat (HP:0001002)	2.35477077
57	Leukodystrophy (HP:0002415)	2.34837552
58	Type I transferrin isoform profile (HP:0003642)	2.31169418
59	Abnormalities of placenta or umbilical cord (HP:0001194)	2.30650372
60	Respiratory failure (HP:0002878)	2.26224907
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25197190
62	Intrahepatic cholestasis (HP:0001406)	2.24959279
63	Increased intramyocellular lipid droplets (HP:0012240)	2.24789969
64	Ileus (HP:0002595)	2.21697100
65	Reduced subcutaneous adipose tissue (HP:0003758)	2.17601204
66	Reticulocytopenia (HP:0001896)	2.16751530
67	Poor speech (HP:0002465)	2.15886764
68	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.14106045
69	Cortical visual impairment (HP:0100704)	2.13085927
70	Proximal tubulopathy (HP:0000114)	2.09584881
71	Methylmalonic acidemia (HP:0002912)	2.09092417
72	Renal tubular dysfunction (HP:0000124)	2.08375937
73	Abnormality of cells of the erythroid lineage (HP:0012130)	2.07945009
74	Reduced antithrombin III activity (HP:0001976)	2.02102922
75	Abnormal urine phosphate concentration (HP:0012599)	2.01741767
76	Hypoalphalipoproteinemia (HP:0003233)	1.99419189
77	Renal tubular acidosis (HP:0001947)	1.97540742
78	Metabolic acidosis (HP:0001942)	1.97136537
79	Dicarboxylic aciduria (HP:0003215)	1.96612125
80	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.96612125
81	Hypolipoproteinemia (HP:0010981)	1.91740931
82	Increased muscle lipid content (HP:0009058)	1.91684379
83	Respiratory difficulties (HP:0002880)	1.91345367
84	Abnormality of pyrimidine metabolism (HP:0004353)	1.90531848
85	Abnormal number of erythroid precursors (HP:0012131)	1.89603099
86	Hypoplastic left heart (HP:0004383)	1.89229274
87	Exertional dyspnea (HP:0002875)	1.88241362
88	Hepatocellular carcinoma (HP:0001402)	1.86119870
89	Conjunctival telangiectasia (HP:0000524)	1.86062900
90	Paralysis (HP:0003470)	1.86057471
91	Cerebral hypomyelination (HP:0006808)	1.83574765
92	Abnormality of subcutaneous fat tissue (HP:0001001)	1.82635590
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82311477
94	Abnormality of glycine metabolism (HP:0010895)	1.82311477
95	Diaphragmatic weakness (HP:0009113)	1.82124318
96	Pallor (HP:0000980)	1.81730464
97	Congenital ichthyosiform erythroderma (HP:0007431)	1.80336532
98	Optic disc pallor (HP:0000543)	1.80020593
99	Toxemia of pregnancy (HP:0100603)	1.78474484
100	Parakeratosis (HP:0001036)	1.78366215

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.48620047
2	CDK9	3.83437240
3	PBK	3.82488780
4	ZAK	3.73407328
5	TLK1	3.47038326
6	RPS6KB2	2.78988991
7	BUB1	2.73185621
8	MAP3K3	2.58810077
9	VRK1	2.52539579
10	PAK4	2.30293732
11	EPHA2	2.22189997
12	SMG1	2.20757067
13	TAF1	2.16464741
14	MST4	2.03916061
15	MAP2K3	2.02655432
16	STK16	1.95678108
17	MAP3K12	1.95365430
18	CCNB1	1.88810703
19	EIF2AK1	1.87780156
20	AURKA	1.77423920
21	CDC7	1.76581699
22	ACVR1B	1.71395132
23	SRPK1	1.67042663
24	TESK1	1.54797375
25	PLK4	1.50565928
26	EIF2AK3	1.49826062
27	NME2	1.47960619
28	TESK2	1.42829380
29	PDK2	1.39495895
30	NUAK1	1.33145976
31	WNK4	1.26820850
32	STK39	1.24458651
33	AURKB	1.13814762
34	LIMK1	1.10945499
35	LMTK2	1.08825555
36	BRSK1	1.07396086
37	PRKCI	1.04998042
38	JAK3	1.03055584
39	KDR	1.02566424
40	OXSR1	1.00024544
41	NME1	0.99446015
42	EIF2AK2	0.98777184
43	RPS6KA5	0.98230596
44	PLK1	0.93353573
45	NEK1	0.92498212
46	DAPK3	0.88319229
47	AKT2	0.87659691
48	NTRK2	0.86900737
49	STK4	0.85556516
50	PTK6	0.81847008
51	PIM2	0.81698870
52	FGR	0.79941320
53	WEE1	0.79218243
54	CSNK1G3	0.77905484
55	PLK3	0.77608754
56	ABL2	0.73275388
57	TTK	0.72829963
58	BCKDK	0.72713952
59	ARAF	0.72635357
60	MYLK	0.69187731
61	CHEK2	0.68174053
62	CDK7	0.67420068
63	ATR	0.66435721
64	ADRBK1	0.65624648
65	CSNK1A1	0.65220596
66	MAP2K1	0.64975356
67	CAMK2G	0.63515262
68	CSNK1G1	0.63298635
69	SCYL2	0.63027418
70	SGK223	0.62028606
71	SGK494	0.62028606
72	BRSK2	0.58252078
73	STK10	0.56375286
74	CSNK1A1L	0.54575616
75	BMPR1B	0.53275046
76	CSNK1G2	0.50284101
77	DYRK2	0.48762529
78	MST1R	0.47362131
79	NTRK3	0.46241060
80	PAK1	0.43976507
81	EPHB2	0.43838458
82	CSNK2A2	0.43583590
83	CAMK2B	0.43235379
84	CSNK2A1	0.41259651
85	PRKCD	0.41199174
86	ILK	0.39767943
87	PHKG2	0.39698816
88	PHKG1	0.39698816
89	CAMK2D	0.38908862
90	TSSK6	0.38839542
91	CHEK1	0.36608332
92	GRK1	0.32294825
93	FER	0.31675558
94	MAP2K7	0.31353859
95	PIM1	0.31166168
96	MINK1	0.29427746
97	MAP3K8	0.26795162
98	DAPK1	0.26408542
99	GRK5	0.21406844
100	ERBB4	0.21027235

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	4.14439056
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40457693
3	Ribosome_Homo sapiens_hsa03010	3.39038776
4	One carbon pool by folate_Homo sapiens_hsa00670	2.99644942
5	Sulfur metabolism_Homo sapiens_hsa00920	2.88588928
6	Sulfur relay system_Homo sapiens_hsa04122	2.67361498
7	Parkinsons disease_Homo sapiens_hsa05012	2.47191133
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.42970361
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.37617019
10	DNA replication_Homo sapiens_hsa03030	2.34754592
11	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.08225771
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.00628496
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.96974242
14	Huntingtons disease_Homo sapiens_hsa05016	1.90266605
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.86661592
16	Mismatch repair_Homo sapiens_hsa03430	1.84423705
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.67046053
18	Alzheimers disease_Homo sapiens_hsa05010	1.64983009
19	Spliceosome_Homo sapiens_hsa03040	1.63601153
20	Homologous recombination_Homo sapiens_hsa03440	1.61633597
21	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58560540
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.58069373
23	Protein export_Homo sapiens_hsa03060	1.56990742
24	Vibrio cholerae infection_Homo sapiens_hsa05110	1.52535555
25	RNA polymerase_Homo sapiens_hsa03020	1.50540577
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.47148574
27	Alcoholism_Homo sapiens_hsa05034	1.40698873
28	Base excision repair_Homo sapiens_hsa03410	1.38846600
29	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.37178074
30	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.32220257
31	Basal transcription factors_Homo sapiens_hsa03022	1.29355601
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.26934337
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.24954609
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.24850884
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.24171671
36	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.23963615
37	RNA transport_Homo sapiens_hsa03013	1.22835118
38	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.18639640
39	Selenocompound metabolism_Homo sapiens_hsa00450	1.17865602
40	Folate biosynthesis_Homo sapiens_hsa00790	1.16924629
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.14713302
42	Pyrimidine metabolism_Homo sapiens_hsa00240	1.14283145
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12811083
44	Glutathione metabolism_Homo sapiens_hsa00480	1.12655175
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.12403275
46	Galactose metabolism_Homo sapiens_hsa00052	1.11015997
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.08438851
48	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.08411309
49	Phenylalanine metabolism_Homo sapiens_hsa00360	1.06726316
50	Carbon metabolism_Homo sapiens_hsa01200	1.06153076
51	Nitrogen metabolism_Homo sapiens_hsa00910	1.00009928
52	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98573144
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.95921363
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95733633
55	Peroxisome_Homo sapiens_hsa04146	0.94786511
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94659764
57	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92827846
58	Retinol metabolism_Homo sapiens_hsa00830	0.92195736
59	Fatty acid elongation_Homo sapiens_hsa00062	0.91976359
60	RNA degradation_Homo sapiens_hsa03018	0.90493864
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.87401914
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85236158
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84979644
64	Metabolic pathways_Homo sapiens_hsa01100	0.84071489
65	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79894579
66	Purine metabolism_Homo sapiens_hsa00230	0.77772318
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.77375620
68	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.77012339
69	Butanoate metabolism_Homo sapiens_hsa00650	0.73979219
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.73725854
71	mRNA surveillance pathway_Homo sapiens_hsa03015	0.72480402
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.71101085
73	Other glycan degradation_Homo sapiens_hsa00511	0.70474329
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69760190
75	Propanoate metabolism_Homo sapiens_hsa00640	0.68853835
76	Pyruvate metabolism_Homo sapiens_hsa00620	0.68635832
77	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65162711
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62723900
79	Fatty acid degradation_Homo sapiens_hsa00071	0.62399358
80	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58737621
81	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.57621319
82	Thyroid cancer_Homo sapiens_hsa05216	0.56733036
83	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.49134226
84	Cell cycle_Homo sapiens_hsa04110	0.48684217
85	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48020194
86	Histidine metabolism_Homo sapiens_hsa00340	0.46904914
87	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45486799
88	Pentose phosphate pathway_Homo sapiens_hsa00030	0.45087997
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42694281
90	Regulation of autophagy_Homo sapiens_hsa04140	0.40426156
91	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.37977073
92	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.36451403
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.35834392
94	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33708708
95	Non-homologous end-joining_Homo sapiens_hsa03450	0.33028273
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.31967168
97	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.29058572
98	Mineral absorption_Homo sapiens_hsa04978	0.26580755
99	Viral carcinogenesis_Homo sapiens_hsa05203	0.24701990
100	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.24621135

KRT18P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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