ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	8.09080459
2	purine nucleotide salvage (GO:0032261)	6.06817341
3	GMP metabolic process (GO:0046037)	5.73662096
4	IMP biosynthetic process (GO:0006188)	5.32861254
5	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.31861956
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.31861956
7	folic acid-containing compound biosynthetic process (GO:0009396)	5.04035889
8	cysteine metabolic process (GO:0006534)	4.92755641
9	adenosine metabolic process (GO:0046085)	4.86548022
10	sulfur amino acid catabolic process (GO:0000098)	4.80494749
11	NADH dehydrogenase complex assembly (GO:0010257)	4.64527967
12	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.64527967
13	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.64527967
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.50238298
15	proteasome assembly (GO:0043248)	4.47840266
16	IMP metabolic process (GO:0046040)	4.32156979
17	protein complex biogenesis (GO:0070271)	4.22116459
18	ribosomal small subunit assembly (GO:0000028)	4.19390904
19	kinetochore assembly (GO:0051382)	3.97470116
20	CENP-A containing nucleosome assembly (GO:0034080)	3.94422069
21	chromatin remodeling at centromere (GO:0031055)	3.93290393
22	inner mitochondrial membrane organization (GO:0007007)	3.91036373
23	mitochondrial RNA metabolic process (GO:0000959)	3.87864371
24	pteridine-containing compound biosynthetic process (GO:0042559)	3.84550477
25	serine family amino acid biosynthetic process (GO:0009070)	3.84504722
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.81030304
27	regulation of plasminogen activation (GO:0010755)	3.79454955
28	rRNA methylation (GO:0031167)	3.78688073
29	purine nucleobase biosynthetic process (GO:0009113)	3.76239903
30	tetrahydrofolate metabolic process (GO:0046653)	3.75038068
31	sulfur amino acid biosynthetic process (GO:0000097)	3.71826938
32	viral transcription (GO:0019083)	3.69104198
33	L-serine metabolic process (GO:0006563)	3.64049073
34	guanosine-containing compound biosynthetic process (GO:1901070)	3.60420799
35	translational termination (GO:0006415)	3.57371467
36	serine family amino acid catabolic process (GO:0009071)	3.56143840
37	negative regulation of keratinocyte proliferation (GO:0010839)	3.56048378
38	negative regulation of interleukin-1 beta production (GO:0032691)	3.54903164
39	rRNA modification (GO:0000154)	3.49432558
40	protein-cofactor linkage (GO:0018065)	3.45082771
41	nucleotide salvage (GO:0043173)	3.44554418
42	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.43451951
43	ribosomal large subunit biogenesis (GO:0042273)	3.42067346
44	galactose catabolic process (GO:0019388)	3.41047860
45	growth hormone secretion (GO:0030252)	3.34468403
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.33805396
47	DNA ligation (GO:0006266)	3.31359581
48	white fat cell differentiation (GO:0050872)	3.29031560
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.27156994
50	ATP synthesis coupled proton transport (GO:0015986)	3.27156994
51	purine-containing compound salvage (GO:0043101)	3.24355442
52	histone H4-K12 acetylation (GO:0043983)	3.23274671
53	oxygen transport (GO:0015671)	3.22767083
54	positive regulation of endothelial cell differentiation (GO:0045603)	3.22738836
55	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.22468589
56	kinetochore organization (GO:0051383)	3.20025918
57	translational elongation (GO:0006414)	3.15493306
58	ribosome biogenesis (GO:0042254)	3.14922218
59	cotranslational protein targeting to membrane (GO:0006613)	3.14602338
60	protein targeting to ER (GO:0045047)	3.12133075
61	tRNA processing (GO:0008033)	3.07762270
62	DNA replication-independent nucleosome assembly (GO:0006336)	3.06548287
63	DNA replication-independent nucleosome organization (GO:0034724)	3.06548287
64	cellular component biogenesis (GO:0044085)	3.05657187
65	folic acid-containing compound metabolic process (GO:0006760)	3.05189366
66	inner ear receptor cell development (GO:0060119)	3.05083763
67	reciprocal DNA recombination (GO:0035825)	3.04082473
68	reciprocal meiotic recombination (GO:0007131)	3.04082473
69	energy homeostasis (GO:0097009)	3.03349006
70	tRNA modification (GO:0006400)	3.02578888
71	mannosylation (GO:0097502)	3.00065596
72	histone exchange (GO:0043486)	2.94943470
73	aminoglycoside antibiotic metabolic process (GO:0030647)	2.94838732
74	ribonucleoprotein complex biogenesis (GO:0022613)	2.93902941
75	protein localization to endoplasmic reticulum (GO:0070972)	2.93497052
76	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.93235037
77	transcription from mitochondrial promoter (GO:0006390)	2.91582537
78	melanin biosynthetic process (GO:0042438)	2.90928323
79	translational initiation (GO:0006413)	2.87449411
80	adult feeding behavior (GO:0008343)	2.84629172
81	maturation of SSU-rRNA (GO:0030490)	2.83959456
82	cartilage morphogenesis (GO:0060536)	2.81610848
83	nucleobase biosynthetic process (GO:0046112)	2.80189833
84	galactose metabolic process (GO:0006012)	2.79191915
85	serine family amino acid metabolic process (GO:0009069)	2.76928649
86	S-adenosylmethionine metabolic process (GO:0046500)	2.76763369
87	artery smooth muscle contraction (GO:0014824)	2.76390078
88	pseudouridine synthesis (GO:0001522)	2.74604944
89	DNA strand elongation involved in DNA replication (GO:0006271)	2.73739665
90	desmosome organization (GO:0002934)	2.72277752
91	regulation of oxidative phosphorylation (GO:0002082)	2.70768014
92	pteridine-containing compound metabolic process (GO:0042558)	2.69890286
93	viral life cycle (GO:0019058)	2.69712314
94	nucleoside transmembrane transport (GO:1901642)	2.69532617
95	cellular protein complex disassembly (GO:0043624)	2.69509361
96	folic acid metabolic process (GO:0046655)	2.69317060
97	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.68038538
98	negative regulation of interleukin-1 production (GO:0032692)	2.67022577
99	gas transport (GO:0015669)	2.64923756
100	DNA strand elongation (GO:0022616)	2.60752257

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.52419490
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.76470029
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.53564805
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.37419502
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.02600560
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.01192399
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.60013653
8	VDR_22108803_ChIP-Seq_LS180_Human	2.94071883
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.72654948
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56741854
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.51375104
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.35125846
13	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.33678453
14	ELK1_19687146_ChIP-ChIP_HELA_Human	2.23312780
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.20244246
16	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.16426747
17	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.06755717
18	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.05284501
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96252169
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.95682226
21	VDR_23849224_ChIP-Seq_CD4+_Human	1.86164305
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.80360588
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.79797467
24	FUS_26573619_Chip-Seq_HEK293_Human	1.78473023
25	AR_21909140_ChIP-Seq_LNCAP_Human	1.75582312
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.74811286
27	ZNF274_21170338_ChIP-Seq_K562_Hela	1.72798815
28	EWS_26573619_Chip-Seq_HEK293_Human	1.72290596
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.68995362
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.67305038
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.62082068
32	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.62075849
33	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.60025800
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.46858889
35	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45022693
36	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.43448215
37	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.41939672
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41174373
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.40928023
40	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.39412654
41	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.37654117
42	P300_19829295_ChIP-Seq_ESCs_Human	1.37368210
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.32711413
44	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.31668184
45	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.27751626
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.24229847
47	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23439559
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.21470718
49	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.20959496
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18349587
51	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.14484392
52	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.12143313
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11246956
54	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.11176109
55	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.10097663
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09178872
57	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07903815
58	TP53_22573176_ChIP-Seq_HFKS_Human	1.07506531
59	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.05927120
60	PHF8_20622853_ChIP-Seq_HELA_Human	1.02802744
61	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.02688232
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.01803713
63	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98765605
64	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.98753220
65	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.98000768
66	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95766700
67	EZH2_22144423_ChIP-Seq_EOC_Human	0.95044115
68	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.95036870
69	NCOR_22424771_ChIP-Seq_293T_Human	0.92511470
70	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91334762
71	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.90570781
72	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.90209730
73	ERG_20517297_ChIP-Seq_VCAP_Human	0.89956350
74	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.89892813
75	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.89553258
76	HTT_18923047_ChIP-ChIP_STHdh_Human	0.89000249
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.88592460
78	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.88050919
79	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87099249
80	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.85997121
81	NANOG_19829295_ChIP-Seq_ESCs_Human	0.85641609
82	SOX2_19829295_ChIP-Seq_ESCs_Human	0.85641609
83	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85616219
84	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.85418933
85	ER_23166858_ChIP-Seq_MCF-7_Human	0.83703926
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.83537336
87	KDM5A_27292631_Chip-Seq_BREAST_Human	0.83235037
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.82818180
89	NFYB_21822215_ChIP-Seq_K562_Human	0.81901848
90	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.80229190
91	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.80229190
92	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.80229190
93	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79569500
94	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.79120670
95	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.79035163
96	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.78942969
97	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.78611334
98	HOXB7_26014856_ChIP-Seq_BT474_Human	0.78195817
99	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.77778642
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.77291915

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	4.83822004
2	MP0002938_white_spotting	4.30717998
3	MP0000372_irregular_coat_pigmentation	3.29329925
4	MP0005646_abnormal_pituitary_gland	2.93955643
5	MP0005670_abnormal_white_adipose	2.86209803
6	MP0000015_abnormal_ear_pigmentation	2.84677272
7	MP0000566_synostosis	2.78979446
8	MP0005075_abnormal_melanosome_morpholog	2.78051350
9	MP0008995_early_reproductive_senescence	2.68070615
10	MP0005360_urolithiasis	2.41069569
11	MP0002095_abnormal_skin_pigmentation	2.40334805
12	MP0003186_abnormal_redox_activity	2.38866711
13	MP0003136_yellow_coat_color	2.34875155
14	MP0008058_abnormal_DNA_repair	2.27148315
15	MP0010030_abnormal_orbit_morphology	2.06036055
16	MP0001324_abnormal_eye_pigmentation	2.04506653
17	MP0010094_abnormal_chromosome_stability	1.98862748
18	MP0005408_hypopigmentation	1.93494840
19	MP0005377_hearing/vestibular/ear_phenot	1.93264675
20	MP0003878_abnormal_ear_physiology	1.93264675
21	MP0001764_abnormal_homeostasis	1.88103522
22	MP0004147_increased_porphyrin_level	1.86324922
23	MP0000516_abnormal_urinary_system	1.86122664
24	MP0005367_renal/urinary_system_phenotyp	1.86122664
25	MP0002837_dystrophic_cardiac_calcinosis	1.80836305
26	MP0000371_diluted_coat_color	1.74307149
27	MP0003315_abnormal_perineum_morphology	1.73937499
28	MP0002102_abnormal_ear_morphology	1.72097827
29	MP0006292_abnormal_olfactory_placode	1.71826678
30	MP0003718_maternal_effect	1.68327997
31	MP0002160_abnormal_reproductive_system	1.62263551
32	MP0008872_abnormal_physiological_respon	1.58482397
33	MP0003693_abnormal_embryo_hatching	1.54899278
34	MP0004885_abnormal_endolymph	1.54803624
35	MP0001293_anophthalmia	1.54207527
36	MP0005171_absent_coat_pigmentation	1.53600764
37	MP0003283_abnormal_digestive_organ	1.47337413
38	MP0004133_heterotaxia	1.40093315
39	MP0003937_abnormal_limbs/digits/tail_de	1.36584414
40	MP0004957_abnormal_blastocyst_morpholog	1.32283071
41	MP0005551_abnormal_eye_electrophysiolog	1.24655416
42	MP0002132_abnormal_respiratory_system	1.23761285
43	MP0002396_abnormal_hematopoietic_system	1.23517549
44	MP0005253_abnormal_eye_physiology	1.17759440
45	MP0005332_abnormal_amino_acid	1.17181053
46	MP0001485_abnormal_pinna_reflex	1.14260473
47	MP0000749_muscle_degeneration	1.11852741
48	MP0003111_abnormal_nucleus_morphology	1.10918208
49	MP0006036_abnormal_mitochondrial_physio	1.09342021
50	MP0001661_extended_life_span	1.07390347
51	MP0005248_abnormal_Harderian_gland	1.07180445
52	MP0002075_abnormal_coat/hair_pigmentati	1.00690066
53	MP0005174_abnormal_tail_pigmentation	0.99738237
54	MP0009697_abnormal_copulation	0.99471290
55	MP0003880_abnormal_central_pattern	0.99424597
56	MP0000534_abnormal_ureter_morphology	0.98336583
57	MP0002295_abnormal_pulmonary_circulatio	0.97269997
58	MP0008932_abnormal_embryonic_tissue	0.97193628
59	MP0008789_abnormal_olfactory_epithelium	0.97162350
60	MP0000631_abnormal_neuroendocrine_gland	0.97081254
61	MP0002735_abnormal_chemical_nociception	0.96810269
62	MP0000537_abnormal_urethra_morphology	0.96054591
63	MP0003890_abnormal_embryonic-extraembry	0.94499772
64	MP0000026_abnormal_inner_ear	0.94395069
65	MP0003786_premature_aging	0.92177308
66	MP0001666_abnormal_nutrient_absorption	0.89280136
67	MP0002697_abnormal_eye_size	0.88943812
68	MP0003941_abnormal_skin_development	0.87865700
69	MP0003646_muscle_fatigue	0.86278386
70	MP0006276_abnormal_autonomic_nervous	0.82563358
71	MP0000013_abnormal_adipose_tissue	0.82187757
72	MP0005197_abnormal_uvea_morphology	0.80733658
73	MP0002234_abnormal_pharynx_morphology	0.80691127
74	MP0001986_abnormal_taste_sensitivity	0.78862531
75	MP0005499_abnormal_olfactory_system	0.78810736
76	MP0005394_taste/olfaction_phenotype	0.78810736
77	MP0005391_vision/eye_phenotype	0.76737951
78	MP0005389_reproductive_system_phenotype	0.75829084
79	MP0002282_abnormal_trachea_morphology	0.75729116
80	MP0009379_abnormal_foot_pigmentation	0.75463598
81	MP0009250_abnormal_appendicular_skeleto	0.75388158
82	MP0002233_abnormal_nose_morphology	0.74320471
83	MP0006054_spinal_hemorrhage	0.74122721
84	MP0004264_abnormal_extraembryonic_tissu	0.73706371
85	MP0002736_abnormal_nociception_after	0.73417743
86	MP0001963_abnormal_hearing_physiology	0.73169772
87	MP0000647_abnormal_sebaceous_gland	0.73124028
88	MP0006072_abnormal_retinal_apoptosis	0.73078430
89	MP0003077_abnormal_cell_cycle	0.72589746
90	MP0003119_abnormal_digestive_system	0.71863302
91	MP0001186_pigmentation_phenotype	0.71651165
92	MP0002210_abnormal_sex_determination	0.71316017
93	MP0003011_delayed_dark_adaptation	0.70717806
94	MP0002751_abnormal_autonomic_nervous	0.70703544
95	MP0001286_abnormal_eye_development	0.68795349
96	MP0001340_abnormal_eyelid_morphology	0.68509145
97	MP0002138_abnormal_hepatobiliary_system	0.68022600
98	MP0005220_abnormal_exocrine_pancreas	0.66622586
99	MP0000653_abnormal_sex_gland	0.66480235
100	MP0005376_homeostasis/metabolism_phenot	0.66126087

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.78918764
2	Abnormality of alanine metabolism (HP:0010916)	4.78918764
3	Hyperalaninemia (HP:0003348)	4.78918764
4	White forelock (HP:0002211)	3.90353777
5	Homocystinuria (HP:0002156)	3.82455357
6	Abnormality of homocysteine metabolism (HP:0010919)	3.82455357
7	Patchy hypopigmentation of hair (HP:0011365)	3.79919606
8	Acute necrotizing encephalopathy (HP:0006965)	3.65235228
9	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.63807462
10	Birth length less than 3rd percentile (HP:0003561)	3.54467339
11	Constricted visual fields (HP:0001133)	3.53997839
12	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.49335452
13	Stenosis of the external auditory canal (HP:0000402)	3.44427008
14	Hyperglycinemia (HP:0002154)	3.44329615
15	Congenital sensorineural hearing impairment (HP:0008527)	3.42257453
16	Reticulocytopenia (HP:0001896)	3.41591010
17	Abnormality of serum amino acid levels (HP:0003112)	3.36588767
18	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30497604
19	Acute encephalopathy (HP:0006846)	3.18905375
20	Progressive macrocephaly (HP:0004481)	3.11993610
21	Pallor (HP:0000980)	2.90530159
22	Mitochondrial inheritance (HP:0001427)	2.86864732
23	Methylmalonic acidemia (HP:0002912)	2.79556183
24	Abnormal hemoglobin (HP:0011902)	2.79442103
25	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.74471597
26	Chromsome breakage (HP:0040012)	2.71982047
27	Increased CSF lactate (HP:0002490)	2.67179921
28	Abnormality of DNA repair (HP:0003254)	2.67052081
29	Toxemia of pregnancy (HP:0100603)	2.66871742
30	Hepatocellular necrosis (HP:0001404)	2.59942049
31	Absent thumb (HP:0009777)	2.59847415
32	Maternal diabetes (HP:0009800)	2.56728364
33	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.50356814
34	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.50356814
35	Cerebral edema (HP:0002181)	2.50290141
36	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.45713356
37	Abnormality of the fetal cardiovascular system (HP:0010948)	2.43561370
38	Abnormal umbilical cord blood vessels (HP:0011403)	2.43561370
39	Single umbilical artery (HP:0001195)	2.43561370
40	Generalized aminoaciduria (HP:0002909)	2.42236836
41	Intestinal atresia (HP:0011100)	2.40655050
42	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.37172583
43	Type I transferrin isoform profile (HP:0003642)	2.35978295
44	Anophthalmia (HP:0000528)	2.35811320
45	Abnormality of midbrain morphology (HP:0002418)	2.35149340
46	Molar tooth sign on MRI (HP:0002419)	2.35149340
47	Optic disc pallor (HP:0000543)	2.35071111
48	3-Methylglutaconic aciduria (HP:0003535)	2.32483553
49	Duplicated collecting system (HP:0000081)	2.32156067
50	Abnormality of the fovea (HP:0000493)	2.32140786
51	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32008341
52	Increased serum lactate (HP:0002151)	2.31667820
53	Microretrognathia (HP:0000308)	2.29105459
54	Macrocytic anemia (HP:0001972)	2.27405227
55	Pancreatic cysts (HP:0001737)	2.24526006
56	Abnormality of methionine metabolism (HP:0010901)	2.24034314
57	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.23647171
58	Abnormality of the renal collecting system (HP:0004742)	2.21745547
59	Lactic acidosis (HP:0003128)	2.19019392
60	Hepatic necrosis (HP:0002605)	2.18042385
61	True hermaphroditism (HP:0010459)	2.16354221
62	Abnormal lung lobation (HP:0002101)	2.15880803
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.15741487
64	Anencephaly (HP:0002323)	2.15358361
65	Renal Fanconi syndrome (HP:0001994)	2.14903550
66	Nausea (HP:0002018)	2.14887265
67	Myocardial infarction (HP:0001658)	2.14021693
68	Small intestinal stenosis (HP:0012848)	2.12611359
69	Duodenal stenosis (HP:0100867)	2.12611359
70	Triphalangeal thumb (HP:0001199)	2.09221814
71	Duplication of thumb phalanx (HP:0009942)	2.08290086
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.08199294
73	Pancreatic fibrosis (HP:0100732)	2.08094442
74	Median cleft lip (HP:0000161)	2.06963376
75	Small hand (HP:0200055)	2.01763752
76	Abnormality of chromosome stability (HP:0003220)	2.01716697
77	Abnormality of the labia minora (HP:0012880)	1.99968910
78	Hypoplasia of the fovea (HP:0007750)	1.99665242
79	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.99665242
80	Conjunctival telangiectasia (HP:0000524)	1.99321292
81	Long clavicles (HP:0000890)	1.98506387
82	Esophageal varix (HP:0002040)	1.96681580
83	Meckel diverticulum (HP:0002245)	1.96677492
84	Attenuation of retinal blood vessels (HP:0007843)	1.96469521
85	Short tibia (HP:0005736)	1.96376330
86	Abnormality of the duodenum (HP:0002246)	1.94889647
87	Ectopic kidney (HP:0000086)	1.94155273
88	Albinism (HP:0001022)	1.93547475
89	Abnormality of the ileum (HP:0001549)	1.89717475
90	Chronic hepatic failure (HP:0100626)	1.85954530
91	Heterochromia iridis (HP:0001100)	1.84977848
92	Methylmalonic aciduria (HP:0012120)	1.84682362
93	Abnormality of renal resorption (HP:0011038)	1.84157298
94	Abnormal number of erythroid precursors (HP:0012131)	1.83908719
95	Abnormality of the preputium (HP:0100587)	1.82220655
96	Morphological abnormality of the inner ear (HP:0011390)	1.81673338
97	Hypoplastic pelvis (HP:0008839)	1.81655879
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.81551929
99	Pendular nystagmus (HP:0012043)	1.81380185
100	Abnormal respiratory epithelium morphology (HP:0012253)	1.80898729

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.35753357
2	LATS1	3.22277870
3	BRSK2	3.07740940
4	BMPR1B	3.02222864
5	CASK	2.95154971
6	EPHA4	2.39901097
7	TRIM28	2.37924161
8	NUAK1	2.29841423
9	PDK2	2.26355185
10	GRK7	2.23340186
11	EPHB2	2.19173303
12	FRK	2.09189446
13	BCKDK	2.07177671
14	FGR	1.98098650
15	WEE1	1.94227905
16	TGFBR1	1.78269249
17	PLK4	1.77702684
18	PBK	1.72733929
19	PNCK	1.67177659
20	PLK3	1.63812478
21	FLT3	1.54785459
22	VRK2	1.53703066
23	PINK1	1.51958499
24	NME2	1.51922023
25	DYRK3	1.50695600
26	MARK3	1.47412964
27	GRK1	1.45693065
28	EIF2AK1	1.38534114
29	MAP2K1	1.35805300
30	CDC7	1.30640588
31	ADRBK1	1.30034222
32	RPS6KB2	1.27124112
33	JAK3	1.26137558
34	MAP3K3	1.25350624
35	MKNK1	1.23870387
36	MKNK2	1.22068006
37	BRSK1	1.20436137
38	OBSCN	1.19139126
39	CDK9	1.19102114
40	CCNB1	1.16954035
41	WNK3	1.14665748
42	NME1	1.11027719
43	TSSK6	1.03108872
44	PLK2	1.01171580
45	ZAK	0.97161752
46	PLK1	0.93176609
47	TNIK	0.89713040
48	TLK1	0.89466282
49	MAP2K3	0.89210755
50	VRK1	0.85837044
51	EIF2AK3	0.82755962
52	STK3	0.82661438
53	NEK1	0.81225789
54	TAF1	0.80280571
55	KSR1	0.74876385
56	BUB1	0.74134918
57	PKN2	0.70960078
58	MYLK	0.70380649
59	PKN1	0.70197269
60	CHEK2	0.69687121
61	DYRK2	0.67983977
62	CSNK1A1	0.66957400
63	AURKB	0.65348335
64	NEK2	0.62880063
65	INSRR	0.57295837
66	ATR	0.56728935
67	SGK223	0.56428249
68	SGK494	0.56428249
69	PASK	0.55378247
70	STK4	0.54830544
71	TGFBR2	0.54390755
72	CSNK2A1	0.54374645
73	FGFR2	0.53581381
74	NTRK2	0.52754053
75	MELK	0.51980754
76	STK39	0.50494689
77	TTK	0.50481433
78	CSNK1G3	0.50035900
79	PRKCE	0.49196504
80	ADRBK2	0.48266614
81	CSNK1G1	0.48225892
82	SRPK1	0.47591774
83	CAMK2D	0.47212981
84	GRK5	0.46725682
85	AURKA	0.46216316
86	CSNK1G2	0.44707272
87	SGK2	0.44492613
88	RPS6KB1	0.43844977
89	CSNK2A2	0.42557648
90	EGFR	0.39833368
91	CSNK1A1L	0.39115314
92	MAP4K2	0.39109809
93	CAMK2G	0.35186779
94	ERBB2	0.33766961
95	CAMK2B	0.33358810
96	RPS6KA5	0.32908935
97	ERBB3	0.32062972
98	ATM	0.30381906
99	DAPK3	0.30202264
100	NEK6	0.29317900

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.64078549
2	Ribosome_Homo sapiens_hsa03010	3.32129832
3	Mismatch repair_Homo sapiens_hsa03430	2.79037894
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.72269908
5	Proteasome_Homo sapiens_hsa03050	2.66979434
6	Sulfur metabolism_Homo sapiens_hsa00920	2.48233144
7	Homologous recombination_Homo sapiens_hsa03440	2.37833420
8	Selenocompound metabolism_Homo sapiens_hsa00450	2.35423470
9	Parkinsons disease_Homo sapiens_hsa05012	2.17837818
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.10823689
11	DNA replication_Homo sapiens_hsa03030	2.09297925
12	RNA polymerase_Homo sapiens_hsa03020	2.07947241
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.00023310
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.98588326
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92143667
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.90761356
17	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.87218904
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.85774367
19	Glutathione metabolism_Homo sapiens_hsa00480	1.84552878
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.82757536
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.80277820
22	Base excision repair_Homo sapiens_hsa03410	1.75242905
23	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.64821529
24	Protein export_Homo sapiens_hsa03060	1.64174984
25	Huntingtons disease_Homo sapiens_hsa05016	1.60613540
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.56484680
27	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.54681050
28	Propanoate metabolism_Homo sapiens_hsa00640	1.50448787
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.38196355
30	Sulfur relay system_Homo sapiens_hsa04122	1.36485568
31	RNA degradation_Homo sapiens_hsa03018	1.34713857
32	Alzheimers disease_Homo sapiens_hsa05010	1.29668635
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24227050
34	RNA transport_Homo sapiens_hsa03013	1.21481397
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.21390309
36	Purine metabolism_Homo sapiens_hsa00230	1.19379057
37	Folate biosynthesis_Homo sapiens_hsa00790	1.17603581
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12904225
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.12669578
40	Spliceosome_Homo sapiens_hsa03040	1.11622101
41	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.08772455
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.08020868
43	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.06841850
44	Nicotine addiction_Homo sapiens_hsa05033	1.03035556
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02136413
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.01964078
47	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01916994
48	Basal transcription factors_Homo sapiens_hsa03022	1.01451552
49	Galactose metabolism_Homo sapiens_hsa00052	1.00703212
50	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.99026539
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.98989377
52	Phototransduction_Homo sapiens_hsa04744	0.93347633
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.92279504
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90090035
55	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.89820841
56	Metabolic pathways_Homo sapiens_hsa01100	0.89778332
57	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.88544604
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88438187
59	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87658476
60	Carbon metabolism_Homo sapiens_hsa01200	0.84959746
61	GABAergic synapse_Homo sapiens_hsa04727	0.81115363
62	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79712387
63	Arginine and proline metabolism_Homo sapiens_hsa00330	0.79519164
64	Regulation of autophagy_Homo sapiens_hsa04140	0.78400782
65	Peroxisome_Homo sapiens_hsa04146	0.78381899
66	Steroid biosynthesis_Homo sapiens_hsa00100	0.78282079
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.76348156
68	Tryptophan metabolism_Homo sapiens_hsa00380	0.74888981
69	Pyruvate metabolism_Homo sapiens_hsa00620	0.73725718
70	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72483991
71	Butanoate metabolism_Homo sapiens_hsa00650	0.69345483
72	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.66688345
73	Retinol metabolism_Homo sapiens_hsa00830	0.66367461
74	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.66233494
75	Morphine addiction_Homo sapiens_hsa05032	0.63932520
76	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.62788565
77	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61935270
78	Olfactory transduction_Homo sapiens_hsa04740	0.59745659
79	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59550100
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.58800599
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.57994289
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.57648861
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57469163
84	Cardiac muscle contraction_Homo sapiens_hsa04260	0.56882872
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54999429
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.51815535
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.51415484
88	Taste transduction_Homo sapiens_hsa04742	0.48021108
89	Cell cycle_Homo sapiens_hsa04110	0.46051620
90	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.44666165
91	Alcoholism_Homo sapiens_hsa05034	0.43725343
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38700970
93	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.38458532
94	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.36492071
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36474137
96	Serotonergic synapse_Homo sapiens_hsa04726	0.35110142
97	Basal cell carcinoma_Homo sapiens_hsa05217	0.32890131
98	Mineral absorption_Homo sapiens_hsa04978	0.31809943
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28245881
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.27728176

KRT18P12

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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