ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	7.72738454
2	ribosomal small subunit assembly (GO:0000028)	7.23695306
3	viral transcription (GO:0019083)	6.31101204
4	translational termination (GO:0006415)	6.02930404
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.67055512
6	protein targeting to ER (GO:0045047)	5.55982099
7	ribosomal small subunit biogenesis (GO:0042274)	5.52969572
8	cotranslational protein targeting to membrane (GO:0006613)	5.51418882
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.27139521
10	oxidative demethylation (GO:0070989)	5.26268305
11	protein localization to endoplasmic reticulum (GO:0070972)	5.25105152
12	maturation of SSU-rRNA (GO:0030490)	5.18012474
13	translational elongation (GO:0006414)	5.03141902
14	phosphate ion transport (GO:0006817)	4.88101706
15	cellular protein complex disassembly (GO:0043624)	4.77251870
16	cellular response to vitamin D (GO:0071305)	4.70284270
17	viral life cycle (GO:0019058)	4.64378016
18	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.45499699
19	ribosomal large subunit biogenesis (GO:0042273)	4.38604536
20	translational initiation (GO:0006413)	4.35438469
21	urate metabolic process (GO:0046415)	4.30155592
22	histone H2A acetylation (GO:0043968)	4.26524273
23	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.24213483
24	L-phenylalanine metabolic process (GO:0006558)	4.24213483
25	xenobiotic catabolic process (GO:0042178)	4.22794028
26	energy homeostasis (GO:0097009)	4.22425750
27	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.18806208
28	L-phenylalanine catabolic process (GO:0006559)	4.18806208
29	peptidyl-tyrosine autophosphorylation (GO:0038083)	4.07930298
30	tricarboxylic acid metabolic process (GO:0072350)	4.03334286
31	regulation of mitochondrial translation (GO:0070129)	4.02282183
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.99572355
33	ATP synthesis coupled proton transport (GO:0015986)	3.99572355
34	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.94811790
35	protein complex disassembly (GO:0043241)	3.93292640
36	establishment of viral latency (GO:0019043)	3.87956316
37	protein targeting to membrane (GO:0006612)	3.78592188
38	macromolecular complex disassembly (GO:0032984)	3.71126713
39	nucleobase-containing small molecule interconversion (GO:0015949)	3.68215793
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.67757975
41	phosphate ion transmembrane transport (GO:0035435)	3.62637862
42	positive regulation by host of viral transcription (GO:0043923)	3.61979971
43	pentose metabolic process (GO:0019321)	3.54195297
44	response to phenylpropanoid (GO:0080184)	3.53254727
45	prepulse inhibition (GO:0060134)	3.52572280
46	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.50820560
47	regulation of hippo signaling (GO:0035330)	3.45992768
48	ribonucleoprotein complex biogenesis (GO:0022613)	3.45224984
49	leukotriene biosynthetic process (GO:0019370)	3.44398690
50	parental behavior (GO:0060746)	3.43740176
51	glycerophospholipid catabolic process (GO:0046475)	3.33016670
52	regulation of G0 to G1 transition (GO:0070316)	3.29510736
53	inositol phosphate-mediated signaling (GO:0048016)	3.27425888
54	translation (GO:0006412)	3.26156236
55	trivalent inorganic anion homeostasis (GO:0072506)	3.21069671
56	phosphate ion homeostasis (GO:0055062)	3.21069671
57	negative regulation of Rho protein signal transduction (GO:0035024)	3.19996614
58	maternal behavior (GO:0042711)	3.16846933
59	aminoglycoside antibiotic metabolic process (GO:0030647)	3.15216712
60	cellular response to vitamin (GO:0071295)	3.13924691
61	regulation of superoxide anion generation (GO:0032928)	3.13461523
62	protein complex biogenesis (GO:0070271)	3.10371027
63	negative regulation of glycoprotein biosynthetic process (GO:0010561)	3.09834930
64	chromatin silencing (GO:0006342)	3.08964811
65	protein autoprocessing (GO:0016540)	3.08848457
66	parturition (GO:0007567)	3.08689153
67	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08405199
68	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.08238687
69	NADH dehydrogenase complex assembly (GO:0010257)	3.08238687
70	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.08238687
71	regulation of cellular respiration (GO:0043457)	3.08048523
72	cellular component biogenesis (GO:0044085)	3.04979444
73	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.02478745
74	glutathione metabolic process (GO:0006749)	2.99536431
75	response to pheromone (GO:0019236)	2.99464645
76	regulation of oxidative phosphorylation (GO:0002082)	2.99431991
77	CTP biosynthetic process (GO:0006241)	2.96044078
78	CTP metabolic process (GO:0046036)	2.96044078
79	glutathione derivative biosynthetic process (GO:1901687)	2.93251905
80	glutathione derivative metabolic process (GO:1901685)	2.93251905
81	pore complex assembly (GO:0046931)	2.93199711
82	artery smooth muscle contraction (GO:0014824)	2.93079752
83	regulation of RNA export from nucleus (GO:0046831)	2.91747367
84	GTP biosynthetic process (GO:0006183)	2.91174916
85	mitochondrial calcium ion transport (GO:0006851)	2.90217184
86	mRNA catabolic process (GO:0006402)	2.88604461
87	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	2.87275991
88	spliceosomal snRNP assembly (GO:0000387)	2.86721163
89	spermatid development (GO:0007286)	2.81130959
90	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.79228874
91	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.78853114
92	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76241140
93	vesicle fusion (GO:0006906)	2.72891736
94	nuclear pore complex assembly (GO:0051292)	2.71667471
95	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.71664631
96	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.71071624
97	regulation of dopamine metabolic process (GO:0042053)	2.69761899
98	regulation of catecholamine metabolic process (GO:0042069)	2.69761899
99	formation of translation preinitiation complex (GO:0001731)	2.68613803
100	UTP biosynthetic process (GO:0006228)	2.67746594

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.53762627
2	GATA1_22025678_ChIP-Seq_K562_Human	5.96592254
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.23069071
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.90140967
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.69428233
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50560902
7	ZNF263_19887448_ChIP-Seq_K562_Human	3.36651091
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.23255243
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.19207818
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.08177761
11	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.98046647
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.86037847
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.85599035
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63352911
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.27203412
16	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.24172539
17	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.22165700
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.08795630
19	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.06795353
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.05630273
21	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.02192669
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.99880780
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99759211
24	ZNF274_21170338_ChIP-Seq_K562_Hela	1.96071806
25	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.84767026
26	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.83856469
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.77358080
28	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.60792025
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.58777230
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.54568506
31	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.52126187
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.50114126
33	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.44051042
34	XRN2_22483619_ChIP-Seq_HELA_Human	1.38974266
35	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.38127667
36	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.38083766
37	FUS_26573619_Chip-Seq_HEK293_Human	1.36987257
38	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.36479851
39	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.33513861
40	TCF3_18692474_ChIP-Seq_MEFs_Mouse	1.31944607
41	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.24157258
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23464691
43	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.23198303
44	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22969930
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.22381066
46	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.22061284
47	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21718574
48	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.21068935
49	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.19038629
50	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17857569
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.16315670
52	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.11266577
53	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.10784142
54	OCT4_20526341_ChIP-Seq_ESCs_Human	1.10418226
55	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08734061
56	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.08530240
57	AR_20517297_ChIP-Seq_VCAP_Human	1.06765461
58	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	1.06545565
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04231012
60	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.04156194
61	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03545807
62	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.99422791
63	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.98106882
64	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96792820
65	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.96336458
66	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.94391592
67	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.93725978
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92994310
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92994310
70	NCOR_22424771_ChIP-Seq_293T_Human	0.92296562
71	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.92274074
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.91891200
73	IRF1_19129219_ChIP-ChIP_H3396_Human	0.91771088
74	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.90471520
75	CTCF_20526341_ChIP-Seq_ESCs_Human	0.88572703
76	ERA_21632823_ChIP-Seq_H3396_Human	0.88306522
77	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.87814403
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.86779527
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.84662461
80	E2F1_20622854_ChIP-Seq_HELA_Human	0.84503994
81	BCL6_27268052_Chip-Seq_Bcells_Human	0.82196575
82	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.81502216
83	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.80709940
84	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.79097600
85	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.77138882
86	SPI1_20517297_ChIP-Seq_HL60_Human	0.76652805
87	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.75411952
88	SMAD1_18555785_Chip-Seq_ESCs_Mouse	0.74922762
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.74412071
90	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.74199648
91	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.73840211
92	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.73484703
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.73202584
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.73164631
95	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.71140160
96	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.71137598
97	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.70864743
98	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.70812714
99	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.70188099
100	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.69918835

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.94605846
2	MP0000372_irregular_coat_pigmentation	4.43787069
3	MP0006292_abnormal_olfactory_placode	4.37635903
4	MP0002163_abnormal_gland_morphology	3.89921113
5	MP0003878_abnormal_ear_physiology	3.87968212
6	MP0005377_hearing/vestibular/ear_phenot	3.87968212
7	MP0002938_white_spotting	3.32892953
8	MP0004147_increased_porphyrin_level	3.21675827
9	MP0008875_abnormal_xenobiotic_pharmacok	3.20522286
10	MP0005379_endocrine/exocrine_gland_phen	2.70972664
11	MP0008877_abnormal_DNA_methylation	2.64593705
12	MP0003693_abnormal_embryo_hatching	2.62209114
13	MP0001542_abnormal_bone_strength	2.57182047
14	MP0004185_abnormal_adipocyte_glucose	2.53235599
15	MP0005075_abnormal_melanosome_morpholog	2.48117952
16	MP0001293_anophthalmia	2.36089035
17	MP0005220_abnormal_exocrine_pancreas	2.17607217
18	MP0004019_abnormal_vitamin_homeostasis	2.02769567
19	MP0004133_heterotaxia	2.01998291
20	MP0005408_hypopigmentation	1.96798522
21	MP0009333_abnormal_splenocyte_physiolog	1.93109713
22	MP0008004_abnormal_stomach_pH	1.79113797
23	MP0002736_abnormal_nociception_after	1.78666647
24	MP0000613_abnormal_salivary_gland	1.74609969
25	MP0004233_abnormal_muscle_weight	1.73804226
26	MP0005332_abnormal_amino_acid	1.63935750
27	MP0003786_premature_aging	1.57706392
28	MP0000358_abnormal_cell_content/	1.36344821
29	MP0000631_abnormal_neuroendocrine_gland	1.35332483
30	MP0002697_abnormal_eye_size	1.33231355
31	MP0006035_abnormal_mitochondrial_morpho	1.32946796
32	MP0004808_abnormal_hematopoietic_stem	1.24051474
33	MP0005084_abnormal_gallbladder_morpholo	1.16521786
34	MP0003123_paternal_imprinting	1.16449852
35	MP0003195_calcinosis	1.16212337
36	MP0004957_abnormal_blastocyst_morpholog	1.14735549
37	MP0002277_abnormal_respiratory_mucosa	1.14452494
38	MP0001529_abnormal_vocalization	1.07655763
39	MP0008058_abnormal_DNA_repair	1.06448597
40	MP0002653_abnormal_ependyma_morphology	1.05320755
41	MP0002160_abnormal_reproductive_system	1.03789118
42	MP0010386_abnormal_urinary_bladder	1.03708326
43	MP0000647_abnormal_sebaceous_gland	1.01436922
44	MP0002089_abnormal_postnatal_growth/wei	1.01279353
45	MP0002557_abnormal_social/conspecific_i	0.99267470
46	MP0000470_abnormal_stomach_morphology	0.96888656
47	MP0006072_abnormal_retinal_apoptosis	0.96704219
48	MP0005645_abnormal_hypothalamus_physiol	0.95621270
49	MP0005360_urolithiasis	0.95205910
50	MP0001944_abnormal_pancreas_morphology	0.94278561
51	MP0001968_abnormal_touch/_nociception	0.93610281
52	MP0003806_abnormal_nucleotide_metabolis	0.91392063
53	MP0009250_abnormal_appendicular_skeleto	0.90194819
54	MP0008872_abnormal_physiological_respon	0.89169974
55	MP0002127_abnormal_cardiovascular_syste	0.88102910
56	MP0010352_gastrointestinal_tract_polyps	0.86833758
57	MP0005636_abnormal_mineral_homeostasis	0.86263024
58	MP0002210_abnormal_sex_determination	0.81681485
59	MP0008789_abnormal_olfactory_epithelium	0.78240257
60	MP0001666_abnormal_nutrient_absorption	0.77681429
61	MP0005319_abnormal_enzyme/_coenzyme	0.76599060
62	MP0000516_abnormal_urinary_system	0.75072203
63	MP0005367_renal/urinary_system_phenotyp	0.75072203
64	MP0003077_abnormal_cell_cycle	0.74933163
65	MP0001664_abnormal_digestion	0.74755122
66	MP0001145_abnormal_male_reproductive	0.74743472
67	MP0010094_abnormal_chromosome_stability	0.74329138
68	MP0000762_abnormal_tongue_morphology	0.73572748
69	MP0005085_abnormal_gallbladder_physiolo	0.72647778
70	MP0003937_abnormal_limbs/digits/tail_de	0.72423432
71	MP0001765_abnormal_ion_homeostasis	0.72141897
72	MP0009672_abnormal_birth_weight	0.71513355
73	MP0001929_abnormal_gametogenesis	0.71317639
74	MP0002928_abnormal_bile_duct	0.70730746
75	MP0001881_abnormal_mammary_gland	0.70532450
76	MP0000653_abnormal_sex_gland	0.68344528
77	MP0001485_abnormal_pinna_reflex	0.65959822
78	MP0006036_abnormal_mitochondrial_physio	0.62623841
79	MP0001348_abnormal_lacrimal_gland	0.62125563
80	MP0001730_embryonic_growth_arrest	0.62081052
81	MP0001756_abnormal_urination	0.61846076
82	MP0005395_other_phenotype	0.61449690
83	MP0003136_yellow_coat_color	0.61371510
84	MP0005193_abnormal_anterior_eye	0.60683215
85	MP0003718_maternal_effect	0.60137754
86	MP0001663_abnormal_digestive_system	0.59663996
87	MP0009643_abnormal_urine_homeostasis	0.59543156
88	MP0005551_abnormal_eye_electrophysiolog	0.59480755
89	MP0005448_abnormal_energy_balance	0.58823153
90	MP0002168_other_aberrant_phenotype	0.57366845
91	MP0002909_abnormal_adrenal_gland	0.56810125
92	MP0005195_abnormal_posterior_eye	0.56215303
93	MP0006276_abnormal_autonomic_nervous	0.56169981
94	MP0000367_abnormal_coat/_hair	0.56096866
95	MP0000538_abnormal_urinary_bladder	0.53579241
96	MP0010234_abnormal_vibrissa_follicle	0.53002337
97	MP0000678_abnormal_parathyroid_gland	0.52631974
98	MP0000858_altered_metastatic_potential	0.52246561
99	MP0010678_abnormal_skin_adnexa	0.52214768
100	MP0001286_abnormal_eye_development	0.51978260

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	4.72579844
2	Abnormal number of erythroid precursors (HP:0012131)	4.66398940
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.51902459
4	Pendular nystagmus (HP:0012043)	4.37192031
5	Reticulocytopenia (HP:0001896)	4.32490098
6	Bile duct proliferation (HP:0001408)	4.27047281
7	Abnormal biliary tract physiology (HP:0012439)	4.27047281
8	Hyperglycinuria (HP:0003108)	4.21791138
9	Acute necrotizing encephalopathy (HP:0006965)	4.08044836
10	Proximal tubulopathy (HP:0000114)	3.98156788
11	True hermaphroditism (HP:0010459)	3.80335001
12	Abnormality of aromatic amino acid family metabolism (HP:0004338)	3.77088703
13	Severe visual impairment (HP:0001141)	3.74074259
14	Acute encephalopathy (HP:0006846)	3.65713904
15	Abnormal mitochondria in muscle tissue (HP:0008316)	3.56721061
16	Pancreatic fibrosis (HP:0100732)	3.48016906
17	Progressive macrocephaly (HP:0004481)	3.42870613
18	Cystic liver disease (HP:0006706)	3.21029326
19	Cone-rod dystrophy (HP:0000548)	3.16253970
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.15711036
21	Microvesicular hepatic steatosis (HP:0001414)	3.10672722
22	Macrocytic anemia (HP:0001972)	3.10277684
23	Parakeratosis (HP:0001036)	3.03175206
24	Abnormality of glycine metabolism (HP:0010895)	3.01925177
25	Abnormality of serine family amino acid metabolism (HP:0010894)	3.01925177
26	Pancreatic cysts (HP:0001737)	2.95889221
27	Degeneration of anterior horn cells (HP:0002398)	2.86301662
28	Abnormality of the anterior horn cell (HP:0006802)	2.86301662
29	Abnormal tarsal ossification (HP:0008369)	2.85831689
30	Amelogenesis imperfecta (HP:0000705)	2.84085150
31	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.65806226
32	Chronic hepatic failure (HP:0100626)	2.63313539
33	Flat acetabular roof (HP:0003180)	2.58282601
34	Sclerocornea (HP:0000647)	2.55228867
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53566484
36	Paralysis (HP:0003470)	2.48339176
37	Type 2 muscle fiber atrophy (HP:0003554)	2.48314417
38	Attenuation of retinal blood vessels (HP:0007843)	2.48170659
39	Mitochondrial inheritance (HP:0001427)	2.45846298
40	Cerebral edema (HP:0002181)	2.42087220
41	Amniotic constriction ring (HP:0009775)	2.38520913
42	Abnormality of placental membranes (HP:0011409)	2.38520913
43	Optic nerve hypoplasia (HP:0000609)	2.38259390
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.37581275
45	Beaking of vertebral bodies (HP:0004568)	2.37039726
46	Nephronophthisis (HP:0000090)	2.31052881
47	Optic disc pallor (HP:0000543)	2.30982682
48	Hypoplastic pelvis (HP:0008839)	2.29675860
49	Aplasia of the musculature (HP:0100854)	2.29211734
50	Congenital hepatic fibrosis (HP:0002612)	2.28944688
51	Septo-optic dysplasia (HP:0100842)	2.22936867
52	Postaxial foot polydactyly (HP:0001830)	2.22564307
53	Male pseudohermaphroditism (HP:0000037)	2.22332501
54	Posterior subcapsular cataract (HP:0007787)	2.21135683
55	Adactyly (HP:0009776)	2.20501513
56	Flat capital femoral epiphysis (HP:0003370)	2.18677600
57	Colon cancer (HP:0003003)	2.17799939
58	Lethargy (HP:0001254)	2.17346196
59	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.16059911
60	Abnormality of alanine metabolism (HP:0010916)	2.16059911
61	Hyperalaninemia (HP:0003348)	2.16059911
62	Hepatoblastoma (HP:0002884)	2.15287959
63	Congenital stationary night blindness (HP:0007642)	2.14763734
64	Muscle fiber atrophy (HP:0100295)	2.13739664
65	Abnormality of macular pigmentation (HP:0008002)	2.09594680
66	Ketoacidosis (HP:0001993)	2.09188279
67	Maternal diabetes (HP:0009800)	2.07457311
68	Increased CSF lactate (HP:0002490)	2.07027971
69	Testicular atrophy (HP:0000029)	2.04946844
70	Abolished electroretinogram (ERG) (HP:0000550)	2.03131965
71	Abnormality of dental color (HP:0011073)	2.02762976
72	Aplasia/Hypoplasia of the scapulae (HP:0006713)	1.98894889
73	Hypoplastic scapulae (HP:0000882)	1.98894889
74	Stenosis of the external auditory canal (HP:0000402)	1.95959080
75	Progressive muscle weakness (HP:0003323)	1.94112699
76	Molar tooth sign on MRI (HP:0002419)	1.92879625
77	Abnormality of midbrain morphology (HP:0002418)	1.92879625
78	Absent thumb (HP:0009777)	1.90572454
79	Abnormality of the renal medulla (HP:0100957)	1.90287804
80	Anencephaly (HP:0002323)	1.88759105
81	Adrenal hypoplasia (HP:0000835)	1.86006586
82	Abnormal foot bone ossification (HP:0010675)	1.85602265
83	Optic nerve coloboma (HP:0000588)	1.83462895
84	Nonprogressive disorder (HP:0003680)	1.83313030
85	Congenital, generalized hypertrichosis (HP:0004540)	1.81629630
86	Leukodystrophy (HP:0002415)	1.80154580
87	Decreased central vision (HP:0007663)	1.78085281
88	Oligodactyly (HP:0012165)	1.77610412
89	Portal hypertension (HP:0001409)	1.76939498
90	Furrowed tongue (HP:0000221)	1.74217255
91	Decreased muscle mass (HP:0003199)	1.73335059
92	Pallor (HP:0000980)	1.73084503
93	Dyschromatopsia (HP:0007641)	1.70494603
94	Hypobetalipoproteinemia (HP:0003563)	1.68041294
95	Depressed nasal ridge (HP:0000457)	1.66500822
96	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.65580869
97	Occipital encephalocele (HP:0002085)	1.65546761
98	Poor speech (HP:0002465)	1.64843569
99	Popliteal pterygium (HP:0009756)	1.63895525
100	3-Methylglutaconic aciduria (HP:0003535)	1.62860429

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHA2	7.71516359
2	CDK19	5.36087580
3	NTRK3	3.68739774
4	TXK	3.30471164
5	BCKDK	3.03408138
6	TLK1	2.78919375
7	NME2	2.62294680
8	VRK1	2.50817608
9	ZAK	2.41313125
10	BUB1	2.32353008
11	VRK2	2.22303574
12	TIE1	2.18582403
13	NEK1	2.05422248
14	FRK	1.88729938
15	PBK	1.85976097
16	STK39	1.78858110
17	PINK1	1.76416851
18	MST4	1.54495632
19	LMTK2	1.53898468
20	CHEK2	1.36107209
21	LRRK2	1.26489387
22	TESK1	1.24990286
23	AURKA	1.24371827
24	ADRBK2	1.21993534
25	RPS6KB2	1.21475599
26	GRK1	1.13960122
27	CDK4	1.11150223
28	OXSR1	1.08704890
29	WNK4	0.96813758
30	LIMK1	0.94838495
31	NME1	0.93759769
32	MST1R	0.91415162
33	DAPK3	0.82590829
34	MAP2K2	0.80777111
35	CAMK1G	0.74326042
36	PDK2	0.74222570
37	MAP2K7	0.71052124
38	KDR	0.68311306
39	CAMK1	0.68018880
40	PRKACB	0.67282825
41	AKT2	0.64992375
42	PAK1	0.64755167
43	ILK	0.64322682
44	MAPK15	0.63753927
45	MAP2K6	0.61181394
46	PRKCD	0.60580266
47	RPS6KA5	0.59955183
48	CAMK1D	0.59465838
49	ACVR1B	0.57194757
50	GRK7	0.56020836
51	CAMK2B	0.55455848
52	PHKG2	0.55146134
53	PHKG1	0.55146134
54	MYLK	0.54007733
55	AURKB	0.53663006
56	CHEK1	0.52730652
57	PLK3	0.52411642
58	EIF2AK1	0.51862712
59	STK11	0.50274109
60	TESK2	0.48938175
61	BRSK1	0.47957144
62	PRKCE	0.46242957
63	MAP3K8	0.45802007
64	FER	0.44153670
65	BRSK2	0.43135827
66	MATK	0.42345205
67	PTK6	0.41059146
68	MAP3K2	0.40723634
69	IKBKB	0.37561673
70	PNCK	0.37527791
71	PRKCG	0.36410292
72	BLK	0.35253602
73	CDK8	0.35248959
74	STK16	0.34426071
75	PRKCI	0.33888663
76	EPHA4	0.33840636
77	BMPR1B	0.33799026
78	PRKD2	0.33095036
79	ADRBK1	0.32921786
80	DAPK2	0.32548402
81	GRK5	0.32505714
82	MAP4K1	0.32101877
83	RIPK1	0.31726297
84	PAK4	0.30547135
85	NEK9	0.29479068
86	ABL2	0.29024717
87	CAMK2G	0.29006535
88	PIM1	0.28930009
89	CSNK1A1	0.26794848
90	CAMK2D	0.26735126
91	PRKACG	0.26522894
92	PRKACA	0.26183270
93	PLK1	0.26087900
94	INSRR	0.25740285
95	STK4	0.25631428
96	SRC	0.25489728
97	MAPKAPK2	0.25302797
98	DYRK3	0.24555615
99	CSNK2A1	0.24115418
100	GRK6	0.23960036

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.29551593
2	Proteasome_Homo sapiens_hsa03050	3.19531117
3	Renin-angiotensin system_Homo sapiens_hsa04614	3.07063454
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.86935288
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.61489014
6	Parkinsons disease_Homo sapiens_hsa05012	2.58986399
7	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.24930313
8	Sulfur relay system_Homo sapiens_hsa04122	2.23065375
9	Nitrogen metabolism_Homo sapiens_hsa00910	1.94776207
10	Basal transcription factors_Homo sapiens_hsa03022	1.90326546
11	Glutathione metabolism_Homo sapiens_hsa00480	1.87572342
12	Non-homologous end-joining_Homo sapiens_hsa03450	1.83682105
13	Huntingtons disease_Homo sapiens_hsa05016	1.77832143
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.74645862
15	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.74362684
16	Sulfur metabolism_Homo sapiens_hsa00920	1.71358648
17	Fatty acid elongation_Homo sapiens_hsa00062	1.65499725
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61912630
19	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.60401840
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.57956745
21	Alcoholism_Homo sapiens_hsa05034	1.54600115
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.53614515
23	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.53073784
24	Alzheimers disease_Homo sapiens_hsa05010	1.52035253
25	Chemical carcinogenesis_Homo sapiens_hsa05204	1.43735484
26	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.43350226
27	Butanoate metabolism_Homo sapiens_hsa00650	1.39939545
28	RNA polymerase_Homo sapiens_hsa03020	1.39249305
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37643420
30	Phototransduction_Homo sapiens_hsa04744	1.36096144
31	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32313039
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.31578242
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.31195642
34	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30344731
35	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29580091
36	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.29065792
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.28635768
38	Spliceosome_Homo sapiens_hsa03040	1.25939721
39	One carbon pool by folate_Homo sapiens_hsa00670	1.24257485
40	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.23886022
41	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.18099401
42	Retinol metabolism_Homo sapiens_hsa00830	1.14622475
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.13114606
44	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02786496
45	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.99576556
46	DNA replication_Homo sapiens_hsa03030	0.95660732
47	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.92826924
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91474136
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.89808761
50	Homologous recombination_Homo sapiens_hsa03440	0.89708946
51	RNA degradation_Homo sapiens_hsa03018	0.89170645
52	RNA transport_Homo sapiens_hsa03013	0.88527027
53	Tyrosine metabolism_Homo sapiens_hsa00350	0.88059732
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.87260569
55	Galactose metabolism_Homo sapiens_hsa00052	0.85433495
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84587132
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.82013065
58	Fatty acid degradation_Homo sapiens_hsa00071	0.80715876
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.79983572
60	Metabolic pathways_Homo sapiens_hsa01100	0.79224339
61	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.79212258
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.77185954
63	Cocaine addiction_Homo sapiens_hsa05030	0.76546570
64	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74157939
65	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.73768338
66	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.73507491
67	Tight junction_Homo sapiens_hsa04530	0.71330868
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70570555
69	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.70291525
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68986851
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.67779059
72	Mismatch repair_Homo sapiens_hsa03430	0.63707983
73	Glycerolipid metabolism_Homo sapiens_hsa00561	0.60961653
74	Sphingolipid metabolism_Homo sapiens_hsa00600	0.60711111
75	Base excision repair_Homo sapiens_hsa03410	0.60022012
76	Carbon metabolism_Homo sapiens_hsa01200	0.55924957
77	Nicotine addiction_Homo sapiens_hsa05033	0.55879872
78	Histidine metabolism_Homo sapiens_hsa00340	0.55768820
79	Pentose phosphate pathway_Homo sapiens_hsa00030	0.55733787
80	Purine metabolism_Homo sapiens_hsa00230	0.53770608
81	Taste transduction_Homo sapiens_hsa04742	0.52735150
82	Regulation of autophagy_Homo sapiens_hsa04140	0.52367985
83	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51896401
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.50523153
85	Protein export_Homo sapiens_hsa03060	0.50373893
86	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.48572518
87	Amphetamine addiction_Homo sapiens_hsa05031	0.47982479
88	Vibrio cholerae infection_Homo sapiens_hsa05110	0.47829736
89	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44883097
90	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44110995
91	Steroid biosynthesis_Homo sapiens_hsa00100	0.42919333
92	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42288953
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.39963324
94	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.37958382
95	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37314901
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.35117246
97	Folate biosynthesis_Homo sapiens_hsa00790	0.34762677
98	Caffeine metabolism_Homo sapiens_hsa00232	0.34054636
99	Glucagon signaling pathway_Homo sapiens_hsa04922	0.31360647
100	Serotonergic synapse_Homo sapiens_hsa04726	0.30689485

KRT18P13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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