

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | homocysteine metabolic process (GO:0050667) | 8.07056852 |
| 2 | folic acid-containing compound biosynthetic process (GO:0009396) | 7.54866464 |
| 3 | regulation of plasminogen activation (GO:0010755) | 6.84356658 |
| 4 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 6.68897379 |
| 5 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 6.68897379 |
| 6 | cardiac right ventricle morphogenesis (GO:0003215) | 6.57107800 |
| 7 | sulfur amino acid catabolic process (GO:0000098) | 6.24085069 |
| 8 | cysteine metabolic process (GO:0006534) | 6.23368540 |
| 9 | cochlea development (GO:0090102) | 6.07352842 |
| 10 | pteridine-containing compound biosynthetic process (GO:0042559) | 5.70394932 |
| 11 | ventricular trabecula myocardium morphogenesis (GO:0003222) | 5.67819163 |
| 12 | negative regulation of cardiac muscle cell apoptotic process (GO:0010667) | 5.45627630 |
| 13 | rRNA methylation (GO:0031167) | 5.42188687 |
| 14 | desmosome organization (GO:0002934) | 5.41706141 |
| 15 | alternative mRNA splicing, via spliceosome (GO:0000380) | 5.36949417 |
| 16 | negative regulation of Notch signaling pathway (GO:0045746) | 5.24823423 |
| 17 | microtubule nucleation (GO:0007020) | 5.20148368 |
| 18 | epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198) | 5.16052210 |
| 19 | purine nucleotide salvage (GO:0032261) | 5.12441941 |
| 20 | mitochondrial RNA metabolic process (GO:0000959) | 5.12396921 |
| 21 | L-serine metabolic process (GO:0006563) | 5.11142378 |
| 22 | cardiac epithelial to mesenchymal transition (GO:0060317) | 5.06090217 |
| 23 | rRNA modification (GO:0000154) | 4.91392943 |
| 24 | ventricular cardiac muscle cell development (GO:0055015) | 4.77249447 |
| 25 | white fat cell differentiation (GO:0050872) | 4.66932562 |
| 26 | tetrahydrofolate metabolic process (GO:0046653) | 4.63462122 |
| 27 | Notch signaling involved in heart development (GO:0061314) | 4.61563078 |
| 28 | heart valve formation (GO:0003188) | 4.58599764 |
| 29 | galactose catabolic process (GO:0019388) | 4.51171882 |
| 30 | negative regulation of smooth muscle cell differentiation (GO:0051151) | 4.50475308 |
| 31 | heart trabecula morphogenesis (GO:0061384) | 4.47938365 |
| 32 | adenosine metabolic process (GO:0046085) | 4.36596235 |
| 33 | serine family amino acid biosynthetic process (GO:0009070) | 4.35044131 |
| 34 | folic acid-containing compound metabolic process (GO:0006760) | 4.34549985 |
| 35 | negative regulation of DNA biosynthetic process (GO:2000279) | 4.29104499 |
| 36 | negative regulation of keratinocyte proliferation (GO:0010839) | 4.28687556 |
| 37 | energy homeostasis (GO:0097009) | 4.27012675 |
| 38 | inner ear receptor cell development (GO:0060119) | 4.24605851 |
| 39 | coronary vasculature morphogenesis (GO:0060977) | 4.19095320 |
| 40 | positive regulation of endothelial cell differentiation (GO:0045603) | 4.18144570 |
| 41 | negative regulation of striated muscle cell apoptotic process (GO:0010664) | 4.12166044 |
| 42 | aminoglycoside antibiotic metabolic process (GO:0030647) | 4.04467755 |
| 43 | primary amino compound metabolic process (GO:1901160) | 4.03424117 |
| 44 | sulfur amino acid biosynthetic process (GO:0000097) | 4.03166084 |
| 45 | IMP biosynthetic process (GO:0006188) | 4.01337946 |
| 46 | CENP-A containing nucleosome assembly (GO:0034080) | 3.98928269 |
| 47 | C4-dicarboxylate transport (GO:0015740) | 3.96494318 |
| 48 | negative regulation of transcription regulatory region DNA binding (GO:2000678) | 3.95754907 |
| 49 | pteridine-containing compound metabolic process (GO:0042558) | 3.95402682 |
| 50 | artery smooth muscle contraction (GO:0014824) | 3.95104048 |
| 51 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.88159146 |
| 52 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.88159146 |
| 53 | regulation of gonadotropin secretion (GO:0032276) | 3.83377071 |
| 54 | mesenchymal cell development (GO:0014031) | 3.82975164 |
| 55 | nucleoside transmembrane transport (GO:1901642) | 3.82148207 |
| 56 | galactose metabolic process (GO:0006012) | 3.71290642 |
| 57 | cardiac left ventricle morphogenesis (GO:0003214) | 3.70038411 |
| 58 | chromatin remodeling at centromere (GO:0031055) | 3.67252757 |
| 59 | regulation of cardiac muscle cell apoptotic process (GO:0010665) | 3.63070550 |
| 60 | regulation of tight junction assembly (GO:2000810) | 3.52370641 |
| 61 | trabecula morphogenesis (GO:0061383) | 3.51630714 |
| 62 | protein-cofactor linkage (GO:0018065) | 3.46831060 |
| 63 | maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005) | 3.45200520 |
| 64 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.45081150 |
| 65 | muscle hypertrophy in response to stress (GO:0003299) | 3.45081150 |
| 66 | cardiac muscle adaptation (GO:0014887) | 3.45081150 |
| 67 | negative regulation of Ras GTPase activity (GO:0034261) | 3.42981906 |
| 68 | regulation of vitamin D biosynthetic process (GO:0060556) | 3.40624399 |
| 69 | phosphatidylglycerol biosynthetic process (GO:0006655) | 3.39723803 |
| 70 | replication fork processing (GO:0031297) | 3.39592217 |
| 71 | DNA replication-independent nucleosome organization (GO:0034724) | 3.37846857 |
| 72 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.37846857 |
| 73 | tonic smooth muscle contraction (GO:0014820) | 3.35505962 |
| 74 | regulation of striated muscle cell apoptotic process (GO:0010662) | 3.35316713 |
| 75 | polyamine biosynthetic process (GO:0006596) | 3.34174949 |
| 76 | pseudouridine synthesis (GO:0001522) | 3.31986137 |
| 77 | resolution of meiotic recombination intermediates (GO:0000712) | 3.31822921 |
| 78 | protein-chromophore linkage (GO:0018298) | 3.27238501 |
| 79 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.25269081 |
| 80 | NADH dehydrogenase complex assembly (GO:0010257) | 3.25269081 |
| 81 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.25269081 |
| 82 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.25015583 |
| 83 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.25015583 |
| 84 | DNA replication checkpoint (GO:0000076) | 3.20950067 |
| 85 | regulation of vitamin metabolic process (GO:0030656) | 3.19217187 |
| 86 | histone exchange (GO:0043486) | 3.18318224 |
| 87 | IMP metabolic process (GO:0046040) | 3.18022909 |
| 88 | positive regulation of heart rate (GO:0010460) | 3.15787646 |
| 89 | alpha-amino acid biosynthetic process (GO:1901607) | 3.15482954 |
| 90 | tRNA modification (GO:0006400) | 3.13628325 |
| 91 | glycoside metabolic process (GO:0016137) | 3.12730649 |
| 92 | ribosome biogenesis (GO:0042254) | 3.12245000 |
| 93 | stem cell development (GO:0048864) | 3.09927248 |
| 94 | atrial septum morphogenesis (GO:0060413) | 3.08277726 |
| 95 | histone H4-K12 acetylation (GO:0043983) | 3.06354082 |
| 96 | heart trabecula formation (GO:0060347) | 3.05694153 |
| 97 | serine family amino acid catabolic process (GO:0009071) | 3.04055825 |
| 98 | cell migration involved in heart development (GO:0060973) | 3.03612202 |
| 99 | negative regulation of catenin import into nucleus (GO:0035414) | 3.03029546 |
| 100 | folic acid metabolic process (GO:0046655) | 3.02788640 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.77706061 |
| 2 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 4.02728706 |
| 3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.92210937 |
| 4 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 3.39954682 |
| 5 | AR_21909140_ChIP-Seq_LNCAP_Human | 3.34493646 |
| 6 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 3.32727220 |
| 7 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.80001186 |
| 8 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.71533935 |
| 9 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.67245920 |
| 10 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.31072342 |
| 11 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.30205139 |
| 12 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.28824606 |
| 13 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.11139364 |
| 14 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 2.05382774 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 11.3238023 |
| 16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.99641576 |
| 17 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.92217351 |
| 18 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.90267752 |
| 19 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.80252198 |
| 20 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.79977563 |
| 21 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.77467819 |
| 22 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.75810742 |
| 23 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.74025122 |
| 24 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.70768392 |
| 25 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.68568363 |
| 26 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.68073392 |
| 27 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.67719358 |
| 28 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.58899726 |
| 29 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.58783279 |
| 30 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.58490106 |
| 31 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.57568275 |
| 32 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.48573419 |
| 33 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.46538182 |
| 34 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.46223823 |
| 35 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.45633452 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.42645187 |
| 37 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.41066087 |
| 38 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.39379824 |
| 39 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.35010904 |
| 40 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.32742963 |
| 41 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.32486140 |
| 42 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.32070529 |
| 43 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.31581107 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.28453337 |
| 45 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.26341483 |
| 46 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.24742870 |
| 47 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.18345186 |
| 48 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.16338625 |
| 49 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.15858923 |
| 50 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.15588240 |
| 51 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.12644611 |
| 52 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 1.08989995 |
| 53 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.07811343 |
| 54 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.06256420 |
| 55 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.04747179 |
| 56 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.03786635 |
| 57 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.03767579 |
| 58 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.02784951 |
| 59 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.02112528 |
| 60 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.00336495 |
| 61 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.99295602 |
| 62 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.98868772 |
| 63 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.98320850 |
| 64 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.97110903 |
| 65 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.94874811 |
| 66 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.93622170 |
| 67 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.93510981 |
| 68 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 0.93082460 |
| 69 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.91930824 |
| 70 | NCOR_22424771_ChIP-Seq_293T_Human | 0.91924806 |
| 71 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.90317525 |
| 72 | KDM5A_27292631_Chip-Seq_BREAST_Human | 0.89797620 |
| 73 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.86609105 |
| 74 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.85960272 |
| 75 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 0.85038924 |
| 76 | EWS_26573619_Chip-Seq_HEK293_Human | 0.84693603 |
| 77 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.83883047 |
| 78 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.82398723 |
| 79 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.82054084 |
| 80 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.81965962 |
| 81 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.81820491 |
| 82 | SOX2_22085726_ChIP-Seq_NPCs_Mouse | 0.81466035 |
| 83 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.80917143 |
| 84 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.80659568 |
| 85 | DCP1A_22483619_ChIP-Seq_HELA_Human | 0.78076394 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.77366109 |
| 87 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.77216401 |
| 88 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.76797634 |
| 89 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.76290068 |
| 90 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.76078510 |
| 91 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.75874871 |
| 92 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.75843024 |
| 93 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.75760004 |
| 94 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.74138689 |
| 95 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.74011687 |
| 96 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.73594928 |
| 97 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 0.72512831 |
| 98 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.72095210 |
| 99 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 0.71685436 |
| 100 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.69376011 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0005360_urolithiasis | 4.81802025 |
| 2 | MP0005670_abnormal_white_adipose | 4.56781277 |
| 3 | MP0003183_abnormal_peptide_metabolism | 4.39817103 |
| 4 | MP0009384_cardiac_valve_regurgitation | 4.37969627 |
| 5 | MP0000516_abnormal_urinary_system | 4.28955864 |
| 6 | MP0005367_renal/urinary_system_phenotyp | 4.28955864 |
| 7 | MP0002736_abnormal_nociception_after | 4.13575234 |
| 8 | MP0005646_abnormal_pituitary_gland | 3.35730211 |
| 9 | MP0001661_extended_life_span | 2.69339459 |
| 10 | MP0003186_abnormal_redox_activity | 2.57451025 |
| 11 | MP0002938_white_spotting | 2.54781804 |
| 12 | MP0002396_abnormal_hematopoietic_system | 2.45719047 |
| 13 | MP0004147_increased_porphyrin_level | 2.42866483 |
| 14 | MP0005332_abnormal_amino_acid | 2.39062378 |
| 15 | MP0003705_abnormal_hypodermis_morpholog | 2.36936886 |
| 16 | MP0000013_abnormal_adipose_tissue | 2.24312802 |
| 17 | MP0008995_early_reproductive_senescence | 2.14502273 |
| 18 | MP0001968_abnormal_touch/_nociception | 2.13198517 |
| 19 | MP0004885_abnormal_endolymph | 2.08155072 |
| 20 | MP0008058_abnormal_DNA_repair | 2.07047535 |
| 21 | MP0002163_abnormal_gland_morphology | 1.98050844 |
| 22 | MP0004185_abnormal_adipocyte_glucose | 1.92756625 |
| 23 | MP0003806_abnormal_nucleotide_metabolis | 1.85898549 |
| 24 | MP0002139_abnormal_hepatobiliary_system | 1.82977138 |
| 25 | MP0010094_abnormal_chromosome_stability | 1.82141770 |
| 26 | MP0003880_abnormal_central_pattern | 1.80649786 |
| 27 | MP0000538_abnormal_urinary_bladder | 1.74390259 |
| 28 | MP0001764_abnormal_homeostasis | 1.64126961 |
| 29 | MP0000534_abnormal_ureter_morphology | 1.62643136 |
| 30 | MP0003693_abnormal_embryo_hatching | 1.62099444 |
| 31 | MP0009697_abnormal_copulation | 1.52026791 |
| 32 | MP0004264_abnormal_extraembryonic_tissu | 1.46381694 |
| 33 | MP0008872_abnormal_physiological_respon | 1.45215832 |
| 34 | MP0002127_abnormal_cardiovascular_syste | 1.35889813 |
| 35 | MP0004957_abnormal_blastocyst_morpholog | 1.33812067 |
| 36 | MP0003111_abnormal_nucleus_morphology | 1.30200617 |
| 37 | MP0005379_endocrine/exocrine_gland_phen | 1.26442514 |
| 38 | MP0008875_abnormal_xenobiotic_pharmacok | 1.26203017 |
| 39 | MP0003724_increased_susceptibility_to | 1.21628316 |
| 40 | MP0002735_abnormal_chemical_nociception | 1.18988474 |
| 41 | MP0005085_abnormal_gallbladder_physiolo | 1.17376412 |
| 42 | MP0006138_congestive_heart_failure | 1.15208299 |
| 43 | MP0003942_abnormal_urinary_system | 1.15033968 |
| 44 | MP0005319_abnormal_enzyme/_coenzyme | 1.14844179 |
| 45 | MP0003786_premature_aging | 1.13618173 |
| 46 | MP0001756_abnormal_urination | 1.13440512 |
| 47 | MP0005376_homeostasis/metabolism_phenot | 1.04099272 |
| 48 | MP0002837_dystrophic_cardiac_calcinosis | 1.03840313 |
| 49 | MP0000647_abnormal_sebaceous_gland | 0.98822769 |
| 50 | MP0002095_abnormal_skin_pigmentation | 0.97326694 |
| 51 | MP0002210_abnormal_sex_determination | 0.94942636 |
| 52 | MP0005551_abnormal_eye_electrophysiolog | 0.93529195 |
| 53 | MP0004043_abnormal_pH_regulation | 0.92245756 |
| 54 | MP0005423_abnormal_somatic_nervous | 0.90036823 |
| 55 | MP0003755_abnormal_palate_morphology | 0.89383710 |
| 56 | MP0000566_synostosis | 0.88953409 |
| 57 | MP0005253_abnormal_eye_physiology | 0.85700963 |
| 58 | MP0001905_abnormal_dopamine_level | 0.83546477 |
| 59 | MP0001145_abnormal_male_reproductive | 0.83094212 |
| 60 | MP0005164_abnormal_response_to | 0.82889011 |
| 61 | MP0003890_abnormal_embryonic-extraembry | 0.82394214 |
| 62 | MP0002132_abnormal_respiratory_system | 0.82344037 |
| 63 | MP0008569_lethality_at_weaning | 0.82195889 |
| 64 | MP0004130_abnormal_muscle_cell | 0.80847795 |
| 65 | MP0005365_abnormal_bile_salt | 0.80264366 |
| 66 | MP0006292_abnormal_olfactory_placode | 0.80020068 |
| 67 | MP0000653_abnormal_sex_gland | 0.79750968 |
| 68 | MP0010329_abnormal_lipoprotein_level | 0.79713218 |
| 69 | MP0000026_abnormal_inner_ear | 0.76393836 |
| 70 | MP0009643_abnormal_urine_homeostasis | 0.76194931 |
| 71 | MP0009250_abnormal_appendicular_skeleto | 0.75977122 |
| 72 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.75799151 |
| 73 | MP0008873_increased_physiological_sensi | 0.75764878 |
| 74 | MP0001929_abnormal_gametogenesis | 0.74650295 |
| 75 | MP0001666_abnormal_nutrient_absorption | 0.74197832 |
| 76 | MP0005171_absent_coat_pigmentation | 0.72498606 |
| 77 | MP0002697_abnormal_eye_size | 0.71535169 |
| 78 | MP0005595_abnormal_vascular_smooth | 0.71338129 |
| 79 | MP0001119_abnormal_female_reproductive | 0.69868960 |
| 80 | MP0009115_abnormal_fat_cell | 0.68577636 |
| 81 | MP0002233_abnormal_nose_morphology | 0.67609751 |
| 82 | MP0004883_abnormal_blood_vessel | 0.67036945 |
| 83 | MP0005636_abnormal_mineral_homeostasis | 0.66308383 |
| 84 | MP0005330_cardiomyopathy | 0.65704614 |
| 85 | MP0008932_abnormal_embryonic_tissue | 0.65657998 |
| 86 | MP0004019_abnormal_vitamin_homeostasis | 0.65372103 |
| 87 | MP0003698_abnormal_male_reproductive | 0.64992742 |
| 88 | MP0004133_heterotaxia | 0.64086237 |
| 89 | MP0001486_abnormal_startle_reflex | 0.63769518 |
| 90 | MP0002069_abnormal_eating/drinking_beha | 0.63220326 |
| 91 | MP0002138_abnormal_hepatobiliary_system | 0.61779505 |
| 92 | MP0001286_abnormal_eye_development | 0.60110906 |
| 93 | MP0004233_abnormal_muscle_weight | 0.58078589 |
| 94 | MP0001340_abnormal_eyelid_morphology | 0.56731284 |
| 95 | MP0003936_abnormal_reproductive_system | 0.55899663 |
| 96 | MP0001986_abnormal_taste_sensitivity | 0.53581585 |
| 97 | MP0001919_abnormal_reproductive_system | 0.53507240 |
| 98 | MP0003077_abnormal_cell_cycle | 0.53402285 |
| 99 | MP0000747_muscle_weakness | 0.52573102 |
| 100 | MP0001963_abnormal_hearing_physiology | 0.48856965 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormality of alanine metabolism (HP:0010916) | 8.54381888 |
| 2 | Hyperalaninemia (HP:0003348) | 8.54381888 |
| 3 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 8.54381888 |
| 4 | Esophageal varix (HP:0002040) | 5.20541165 |
| 5 | Constricted visual fields (HP:0001133) | 5.18687459 |
| 6 | Abnormality of the fetal cardiovascular system (HP:0010948) | 4.87290523 |
| 7 | Abnormal umbilical cord blood vessels (HP:0011403) | 4.87290523 |
| 8 | Single umbilical artery (HP:0001195) | 4.87290523 |
| 9 | Congenital sensorineural hearing impairment (HP:0008527) | 4.73566609 |
| 10 | Abnormality of serum amino acid levels (HP:0003112) | 4.67674406 |
| 11 | Spontaneous hematomas (HP:0007420) | 4.37801856 |
| 12 | Hyperglycinemia (HP:0002154) | 4.24626153 |
| 13 | Birth length less than 3rd percentile (HP:0003561) | 4.23757740 |
| 14 | Abnormality of homocysteine metabolism (HP:0010919) | 4.07114976 |
| 15 | Homocystinuria (HP:0002156) | 4.07114976 |
| 16 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 3.84087927 |
| 17 | White forelock (HP:0002211) | 3.79491368 |
| 18 | Generalized aminoaciduria (HP:0002909) | 3.53154206 |
| 19 | Abnormality of the umbilical cord (HP:0010881) | 3.48498302 |
| 20 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.46865599 |
| 21 | Patchy hypopigmentation of hair (HP:0011365) | 3.44486248 |
| 22 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 3.41002367 |
| 23 | Hypoalphalipoproteinemia (HP:0003233) | 3.36128294 |
| 24 | Conjunctival telangiectasia (HP:0000524) | 3.32560304 |
| 25 | Myocardial infarction (HP:0001658) | 3.24452608 |
| 26 | Conjugated hyperbilirubinemia (HP:0002908) | 2.94472542 |
| 27 | Nausea (HP:0002018) | 2.89423702 |
| 28 | Anorexia (HP:0002039) | 2.79510937 |
| 29 | Oligomenorrhea (HP:0000876) | 2.73979008 |
| 30 | Chromsome breakage (HP:0040012) | 2.70272349 |
| 31 | Action tremor (HP:0002345) | 2.67593460 |
| 32 | Abnormality of the vasculature of the conjunctiva (HP:0008054) | 2.60574390 |
| 33 | Arteriovenous malformation (HP:0100026) | 2.60554584 |
| 34 | Chorioretinal atrophy (HP:0000533) | 2.57789971 |
| 35 | Heterochromia iridis (HP:0001100) | 2.56721747 |
| 36 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.54906303 |
| 37 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.54289576 |
| 38 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.52849810 |
| 39 | Pigmentary retinal degeneration (HP:0001146) | 2.45727005 |
| 40 | Biconcave vertebral bodies (HP:0004586) | 2.39260703 |
| 41 | Abnormality of the preputium (HP:0100587) | 2.39176088 |
| 42 | Abnormality of the carotid arteries (HP:0005344) | 2.38359685 |
| 43 | Proximal tubulopathy (HP:0000114) | 2.33954086 |
| 44 | Poor speech (HP:0002465) | 2.32004776 |
| 45 | Cortical visual impairment (HP:0100704) | 2.27801914 |
| 46 | Hypomagnesemia (HP:0002917) | 2.25089794 |
| 47 | Abnormality of serine family amino acid metabolism (HP:0010894) | 2.25035421 |
| 48 | Abnormality of glycine metabolism (HP:0010895) | 2.25035421 |
| 49 | Decreased subcutaneous fat (HP:0001002) | 2.24958169 |
| 50 | Toxemia of pregnancy (HP:0100603) | 2.22324455 |
| 51 | Hypoplastic left heart (HP:0004383) | 2.21167419 |
| 52 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.20827787 |
| 53 | Abnormality of DNA repair (HP:0003254) | 2.20576912 |
| 54 | Meckel diverticulum (HP:0002245) | 2.17972168 |
| 55 | Abnormal lung lobation (HP:0002101) | 2.12671673 |
| 56 | Ileus (HP:0002595) | 2.11942154 |
| 57 | Abnormality of glycolysis (HP:0004366) | 2.10403776 |
| 58 | Bone marrow hypocellularity (HP:0005528) | 2.09286553 |
| 59 | Hypolipoproteinemia (HP:0010981) | 2.08640015 |
| 60 | Abnormality of the ileum (HP:0001549) | 2.07499181 |
| 61 | Cone-rod dystrophy (HP:0000548) | 2.07465506 |
| 62 | Increased serum pyruvate (HP:0003542) | 2.04600186 |
| 63 | Visceral angiomatosis (HP:0100761) | 2.02359757 |
| 64 | Diaphragmatic weakness (HP:0009113) | 2.01923514 |
| 65 | Renal tubular acidosis (HP:0001947) | 2.01315085 |
| 66 | Cavernous hemangioma (HP:0001048) | 1.99957867 |
| 67 | Duplicated collecting system (HP:0000081) | 1.99460004 |
| 68 | Pulmonary embolism (HP:0002204) | 1.99133124 |
| 69 | Attenuation of retinal blood vessels (HP:0007843) | 1.93853996 |
| 70 | Agnosia (HP:0010524) | 1.93846945 |
| 71 | Ependymoma (HP:0002888) | 1.93646519 |
| 72 | Abnormality of cochlea (HP:0000375) | 1.90084148 |
| 73 | Tetany (HP:0001281) | 1.87871813 |
| 74 | Maternal diabetes (HP:0009800) | 1.87595217 |
| 75 | Metabolic acidosis (HP:0001942) | 1.87386732 |
| 76 | Abnormality of methionine metabolism (HP:0010901) | 1.83539459 |
| 77 | Abnormality of the renal collecting system (HP:0004742) | 1.83135884 |
| 78 | Symptomatic seizures (HP:0011145) | 1.81731077 |
| 79 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.81611158 |
| 80 | Abnormal tarsal ossification (HP:0008369) | 1.81342551 |
| 81 | Abnormality of subcutaneous fat tissue (HP:0001001) | 1.81051689 |
| 82 | Abnormality of magnesium homeostasis (HP:0004921) | 1.80777958 |
| 83 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.80179924 |
| 84 | Megaloblastic anemia (HP:0001889) | 1.78841405 |
| 85 | Myopathic facies (HP:0002058) | 1.76717177 |
| 86 | Hemangiomatosis (HP:0007461) | 1.71949930 |
| 87 | Thrombophlebitis (HP:0004418) | 1.71672115 |
| 88 | Chronic hepatic failure (HP:0100626) | 1.68410013 |
| 89 | Clonus (HP:0002169) | 1.68369936 |
| 90 | Paralysis (HP:0003470) | 1.67559729 |
| 91 | Hyperammonemia (HP:0001987) | 1.66473934 |
| 92 | Small intestinal stenosis (HP:0012848) | 1.66294174 |
| 93 | Duodenal stenosis (HP:0100867) | 1.66294174 |
| 94 | Hypoplastic heart (HP:0001961) | 1.63522739 |
| 95 | Ureteral duplication (HP:0000073) | 1.62822724 |
| 96 | Intrahepatic cholestasis (HP:0001406) | 1.61515109 |
| 97 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 1.60191215 |
| 98 | Ectopic anus (HP:0004397) | 1.59945629 |
| 99 | Elevated alkaline phosphatase (HP:0003155) | 1.58804620 |
| 100 | Hepatocellular carcinoma (HP:0001402) | 1.57160569 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K3 | 4.25884676 |
| 2 | PBK | 3.88964788 |
| 3 | CDC7 | 3.31636819 |
| 4 | RPS6KB2 | 3.26785702 |
| 5 | ZAK | 3.11911147 |
| 6 | MAP2K3 | 3.09796491 |
| 7 | CDK9 | 3.02695477 |
| 8 | CCNB1 | 2.79386964 |
| 9 | FGR | 2.79138770 |
| 10 | EPHA2 | 2.16761843 |
| 11 | ACVR1B | 2.10103650 |
| 12 | TLK1 | 2.00862054 |
| 13 | NTRK2 | 1.98214910 |
| 14 | JAK3 | 1.97729556 |
| 15 | VRK2 | 1.91624270 |
| 16 | TAF1 | 1.69646018 |
| 17 | VRK1 | 1.69566736 |
| 18 | STK39 | 1.66803276 |
| 19 | EIF2AK1 | 1.64846597 |
| 20 | DYRK2 | 1.53603360 |
| 21 | EIF2AK3 | 1.44413233 |
| 22 | CSNK1G3 | 1.41848931 |
| 23 | YES1 | 1.40383253 |
| 24 | SMG1 | 1.34676684 |
| 25 | WNK3 | 1.33898836 |
| 26 | BUB1 | 1.32661959 |
| 27 | FRK | 1.30736109 |
| 28 | EPHA4 | 1.29011560 |
| 29 | MAP4K2 | 1.28054485 |
| 30 | LMTK2 | 1.26136374 |
| 31 | EPHB2 | 1.22966812 |
| 32 | MKNK2 | 1.20685519 |
| 33 | AURKA | 1.20516489 |
| 34 | WEE1 | 1.11222832 |
| 35 | SGK223 | 1.11103698 |
| 36 | SGK494 | 1.11103698 |
| 37 | PKN1 | 1.10589347 |
| 38 | PAK4 | 1.09505825 |
| 39 | CSNK1G1 | 1.08039710 |
| 40 | MAP2K7 | 1.07959228 |
| 41 | PDK2 | 1.04716349 |
| 42 | NTRK3 | 1.03957521 |
| 43 | MAP2K1 | 1.00754355 |
| 44 | MST4 | 0.99739024 |
| 45 | CSNK1G2 | 0.98894800 |
| 46 | CAMK1 | 0.96163738 |
| 47 | PRKCI | 0.95342083 |
| 48 | BRSK1 | 0.95070864 |
| 49 | WNK4 | 0.94790675 |
| 50 | CSNK1A1 | 0.94313872 |
| 51 | CHEK2 | 0.93704810 |
| 52 | TNIK | 0.91909020 |
| 53 | OXSR1 | 0.89738587 |
| 54 | CAMK2G | 0.79120378 |
| 55 | PLK3 | 0.79112058 |
| 56 | SGK2 | 0.77729381 |
| 57 | ERBB4 | 0.72839446 |
| 58 | PLK1 | 0.72688714 |
| 59 | NUAK1 | 0.72676848 |
| 60 | AURKB | 0.71324370 |
| 61 | CAMK2B | 0.69341300 |
| 62 | CDK7 | 0.68811022 |
| 63 | MAP3K12 | 0.67221756 |
| 64 | MKNK1 | 0.67043205 |
| 65 | ATR | 0.66167562 |
| 66 | AKT2 | 0.64023962 |
| 67 | CAMK2D | 0.62503146 |
| 68 | ADRBK1 | 0.61581727 |
| 69 | MELK | 0.60329459 |
| 70 | NEK6 | 0.59235925 |
| 71 | CSNK1A1L | 0.57066481 |
| 72 | MAP3K11 | 0.53748735 |
| 73 | DAPK3 | 0.53135333 |
| 74 | TIE1 | 0.51721083 |
| 75 | PRKCD | 0.50819070 |
| 76 | SGK3 | 0.49736495 |
| 77 | PLK4 | 0.49221745 |
| 78 | RPS6KA5 | 0.48708664 |
| 79 | BCKDK | 0.47202830 |
| 80 | GRK1 | 0.43651684 |
| 81 | PRKCE | 0.42924825 |
| 82 | TAOK3 | 0.41886771 |
| 83 | ITK | 0.39808505 |
| 84 | NME1 | 0.39345406 |
| 85 | PLK2 | 0.39255250 |
| 86 | PIM1 | 0.38834992 |
| 87 | TSSK6 | 0.38752430 |
| 88 | EGFR | 0.38001582 |
| 89 | CSNK2A1 | 0.37743069 |
| 90 | RPS6KB1 | 0.37724950 |
| 91 | MAP3K8 | 0.37646164 |
| 92 | STK16 | 0.37342383 |
| 93 | PTK6 | 0.37339523 |
| 94 | STK4 | 0.35921998 |
| 95 | BRSK2 | 0.35720854 |
| 96 | INSR | 0.34866735 |
| 97 | CSNK2A2 | 0.33384299 |
| 98 | NEK1 | 0.31795518 |
| 99 | BMPR1B | 0.31403901 |
| 100 | PRKCA | 0.30854943 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | One carbon pool by folate_Homo sapiens_hsa00670 | 4.76127696 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.51250012 |
| 3 | Arginine biosynthesis_Homo sapiens_hsa00220 | 3.08505827 |
| 4 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.89658846 |
| 5 | Selenocompound metabolism_Homo sapiens_hsa00450 | 2.72941649 |
| 6 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.71226604 |
| 7 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.68747235 |
| 8 | Sulfur relay system_Homo sapiens_hsa04122 | 2.60745993 |
| 9 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 2.30858457 |
| 10 | Proteasome_Homo sapiens_hsa03050 | 2.19530164 |
| 11 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.04833689 |
| 12 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 2.03908860 |
| 13 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.92230287 |
| 14 | Base excision repair_Homo sapiens_hsa03410 | 1.91684810 |
| 15 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.88218970 |
| 16 | Alcoholism_Homo sapiens_hsa05034 | 1.86700863 |
| 17 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.84465091 |
| 18 | DNA replication_Homo sapiens_hsa03030 | 1.79713526 |
| 19 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.71933129 |
| 20 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 1.71257826 |
| 21 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.69784632 |
| 22 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.54504991 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.46904318 |
| 24 | Mismatch repair_Homo sapiens_hsa03430 | 1.44007155 |
| 25 | Galactose metabolism_Homo sapiens_hsa00052 | 1.43181575 |
| 26 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.39363501 |
| 27 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.34051806 |
| 28 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.33839079 |
| 29 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 1.32938639 |
| 30 | Spliceosome_Homo sapiens_hsa03040 | 1.27083977 |
| 31 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.24992850 |
| 32 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.23617310 |
| 33 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.21345863 |
| 34 | Basal transcription factors_Homo sapiens_hsa03022 | 1.20737983 |
| 35 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.18934084 |
| 36 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.18198199 |
| 37 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.15306419 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.14771189 |
| 39 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.11572673 |
| 40 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.09112816 |
| 41 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.06052329 |
| 42 | GABAergic synapse_Homo sapiens_hsa04727 | 1.02332242 |
| 43 | Carbon metabolism_Homo sapiens_hsa01200 | 1.01852711 |
| 44 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.00975936 |
| 45 | Morphine addiction_Homo sapiens_hsa05032 | 0.97588694 |
| 46 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.96251233 |
| 47 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.95833585 |
| 48 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.95256801 |
| 49 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.92835738 |
| 50 | Peroxisome_Homo sapiens_hsa04146 | 0.92143532 |
| 51 | Retinol metabolism_Homo sapiens_hsa00830 | 0.91921156 |
| 52 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.89036511 |
| 53 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.88286569 |
| 54 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.84858756 |
| 55 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.84320811 |
| 56 | Nicotine addiction_Homo sapiens_hsa05033 | 0.83261148 |
| 57 | Homologous recombination_Homo sapiens_hsa03440 | 0.82391582 |
| 58 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.81716212 |
| 59 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.81257510 |
| 60 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.79059037 |
| 61 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.77481571 |
| 62 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.76883763 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.74510552 |
| 64 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.74007356 |
| 65 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.73685281 |
| 66 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.71994627 |
| 67 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.71587690 |
| 68 | RNA transport_Homo sapiens_hsa03013 | 0.71171902 |
| 69 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.70130356 |
| 70 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.69756708 |
| 71 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.67707009 |
| 72 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.65461112 |
| 73 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.63085195 |
| 74 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.62479249 |
| 75 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.59891120 |
| 76 | Histidine metabolism_Homo sapiens_hsa00340 | 0.56954431 |
| 77 | RNA degradation_Homo sapiens_hsa03018 | 0.54063476 |
| 78 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.53705008 |
| 79 | RNA polymerase_Homo sapiens_hsa03020 | 0.53227160 |
| 80 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.51953815 |
| 81 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.51375424 |
| 82 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.51118825 |
| 83 | Glutamatergic synapse_Homo sapiens_hsa04724 | 0.50518902 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48625990 |
| 85 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.48506423 |
| 86 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.48018368 |
| 87 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.47238254 |
| 88 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.47027131 |
| 89 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.45245276 |
| 90 | Purine metabolism_Homo sapiens_hsa00230 | 0.42850401 |
| 91 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.42264250 |
| 92 | Cell cycle_Homo sapiens_hsa04110 | 0.39851938 |
| 93 | Circadian entrainment_Homo sapiens_hsa04713 | 0.38790703 |
| 94 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.37735199 |
| 95 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.36981564 |
| 96 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.35556705 |
| 97 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.33747946 |
| 98 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.32236057 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.30446883 |
| 100 | Thyroid cancer_Homo sapiens_hsa05216 | 0.29904655 |

