KRT18P14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1homocysteine metabolic process (GO:0050667)8.07056852
2folic acid-containing compound biosynthetic process (GO:0009396)7.54866464
3regulation of plasminogen activation (GO:0010755)6.84356658
4tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.68897379
5RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.68897379
6cardiac right ventricle morphogenesis (GO:0003215)6.57107800
7sulfur amino acid catabolic process (GO:0000098)6.24085069
8cysteine metabolic process (GO:0006534)6.23368540
9cochlea development (GO:0090102)6.07352842
10pteridine-containing compound biosynthetic process (GO:0042559)5.70394932
11ventricular trabecula myocardium morphogenesis (GO:0003222)5.67819163
12negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.45627630
13rRNA methylation (GO:0031167)5.42188687
14desmosome organization (GO:0002934)5.41706141
15alternative mRNA splicing, via spliceosome (GO:0000380)5.36949417
16negative regulation of Notch signaling pathway (GO:0045746)5.24823423
17microtubule nucleation (GO:0007020)5.20148368
18epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)5.16052210
19purine nucleotide salvage (GO:0032261)5.12441941
20mitochondrial RNA metabolic process (GO:0000959)5.12396921
21L-serine metabolic process (GO:0006563)5.11142378
22cardiac epithelial to mesenchymal transition (GO:0060317)5.06090217
23rRNA modification (GO:0000154)4.91392943
24ventricular cardiac muscle cell development (GO:0055015)4.77249447
25white fat cell differentiation (GO:0050872)4.66932562
26tetrahydrofolate metabolic process (GO:0046653)4.63462122
27Notch signaling involved in heart development (GO:0061314)4.61563078
28heart valve formation (GO:0003188)4.58599764
29galactose catabolic process (GO:0019388)4.51171882
30negative regulation of smooth muscle cell differentiation (GO:0051151)4.50475308
31heart trabecula morphogenesis (GO:0061384)4.47938365
32adenosine metabolic process (GO:0046085)4.36596235
33serine family amino acid biosynthetic process (GO:0009070)4.35044131
34folic acid-containing compound metabolic process (GO:0006760)4.34549985
35negative regulation of DNA biosynthetic process (GO:2000279)4.29104499
36negative regulation of keratinocyte proliferation (GO:0010839)4.28687556
37energy homeostasis (GO:0097009)4.27012675
38inner ear receptor cell development (GO:0060119)4.24605851
39coronary vasculature morphogenesis (GO:0060977)4.19095320
40positive regulation of endothelial cell differentiation (GO:0045603)4.18144570
41negative regulation of striated muscle cell apoptotic process (GO:0010664)4.12166044
42aminoglycoside antibiotic metabolic process (GO:0030647)4.04467755
43primary amino compound metabolic process (GO:1901160)4.03424117
44sulfur amino acid biosynthetic process (GO:0000097)4.03166084
45IMP biosynthetic process (GO:0006188)4.01337946
46CENP-A containing nucleosome assembly (GO:0034080)3.98928269
47C4-dicarboxylate transport (GO:0015740)3.96494318
48negative regulation of transcription regulatory region DNA binding (GO:2000678)3.95754907
49pteridine-containing compound metabolic process (GO:0042558)3.95402682
50artery smooth muscle contraction (GO:0014824)3.95104048
51DNA replication-dependent nucleosome assembly (GO:0006335)3.88159146
52DNA replication-dependent nucleosome organization (GO:0034723)3.88159146
53regulation of gonadotropin secretion (GO:0032276)3.83377071
54mesenchymal cell development (GO:0014031)3.82975164
55nucleoside transmembrane transport (GO:1901642)3.82148207
56galactose metabolic process (GO:0006012)3.71290642
57cardiac left ventricle morphogenesis (GO:0003214)3.70038411
58chromatin remodeling at centromere (GO:0031055)3.67252757
59regulation of cardiac muscle cell apoptotic process (GO:0010665)3.63070550
60regulation of tight junction assembly (GO:2000810)3.52370641
61trabecula morphogenesis (GO:0061383)3.51630714
62protein-cofactor linkage (GO:0018065)3.46831060
63maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.45200520
64cardiac muscle hypertrophy in response to stress (GO:0014898)3.45081150
65muscle hypertrophy in response to stress (GO:0003299)3.45081150
66cardiac muscle adaptation (GO:0014887)3.45081150
67negative regulation of Ras GTPase activity (GO:0034261)3.42981906
68regulation of vitamin D biosynthetic process (GO:0060556)3.40624399
69phosphatidylglycerol biosynthetic process (GO:0006655)3.39723803
70replication fork processing (GO:0031297)3.39592217
71DNA replication-independent nucleosome organization (GO:0034724)3.37846857
72DNA replication-independent nucleosome assembly (GO:0006336)3.37846857
73tonic smooth muscle contraction (GO:0014820)3.35505962
74regulation of striated muscle cell apoptotic process (GO:0010662)3.35316713
75polyamine biosynthetic process (GO:0006596)3.34174949
76pseudouridine synthesis (GO:0001522)3.31986137
77resolution of meiotic recombination intermediates (GO:0000712)3.31822921
78protein-chromophore linkage (GO:0018298)3.27238501
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.25269081
80NADH dehydrogenase complex assembly (GO:0010257)3.25269081
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25269081
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25015583
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.25015583
84DNA replication checkpoint (GO:0000076)3.20950067
85regulation of vitamin metabolic process (GO:0030656)3.19217187
86histone exchange (GO:0043486)3.18318224
87IMP metabolic process (GO:0046040)3.18022909
88positive regulation of heart rate (GO:0010460)3.15787646
89alpha-amino acid biosynthetic process (GO:1901607)3.15482954
90tRNA modification (GO:0006400)3.13628325
91glycoside metabolic process (GO:0016137)3.12730649
92ribosome biogenesis (GO:0042254)3.12245000
93stem cell development (GO:0048864)3.09927248
94atrial septum morphogenesis (GO:0060413)3.08277726
95histone H4-K12 acetylation (GO:0043983)3.06354082
96heart trabecula formation (GO:0060347)3.05694153
97serine family amino acid catabolic process (GO:0009071)3.04055825
98cell migration involved in heart development (GO:0060973)3.03612202
99negative regulation of catenin import into nucleus (GO:0035414)3.03029546
100folic acid metabolic process (GO:0046655)3.02788640

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.77706061
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.02728706
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.92210937
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.39954682
5AR_21909140_ChIP-Seq_LNCAP_Human3.34493646
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.32727220
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80001186
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71533935
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.67245920
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31072342
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30205139
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28824606
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11139364
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.05382774
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse11.3238023
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.99641576
17MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92217351
18E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90267752
19MYC_18555785_ChIP-Seq_MESCs_Mouse1.80252198
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79977563
21MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77467819
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.75810742
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.74025122
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70768392
25GABP_19822575_ChIP-Seq_HepG2_Human1.68568363
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.68073392
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67719358
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58899726
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58783279
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58490106
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57568275
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48573419
33CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46538182
34FOXP3_21729870_ChIP-Seq_TREG_Human1.46223823
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.45633452
36VDR_22108803_ChIP-Seq_LS180_Human1.42645187
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41066087
38ZNF263_19887448_ChIP-Seq_K562_Human1.39379824
39ZNF274_21170338_ChIP-Seq_K562_Hela1.35010904
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32742963
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32486140
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32070529
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.31581107
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28453337
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26341483
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24742870
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18345186
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16338625
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.15858923
50XRN2_22483619_ChIP-Seq_HELA_Human1.15588240
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12644611
52TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08989995
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07811343
54CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06256420
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.04747179
56E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03786635
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03767579
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02784951
59TP53_22573176_ChIP-Seq_HFKS_Human1.02112528
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.00336495
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99295602
62CDX2_22108803_ChIP-Seq_LS180_Human0.98868772
63ELK1_19687146_ChIP-ChIP_HELA_Human0.98320850
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97110903
65STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.94874811
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93622170
67SRF_21415370_ChIP-Seq_HL-1_Mouse0.93510981
68THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93082460
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91930824
70NCOR_22424771_ChIP-Seq_293T_Human0.91924806
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90317525
72KDM5A_27292631_Chip-Seq_BREAST_Human0.89797620
73CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86609105
74GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85960272
75TCF4_18268006_ChIP-ChIP_LS174T_Human0.85038924
76EWS_26573619_Chip-Seq_HEK293_Human0.84693603
77GATA4_25053715_ChIP-Seq_YYC3_Human0.83883047
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82398723
79ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82054084
80SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.81965962
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.81820491
82SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81466035
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80917143
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.80659568
85DCP1A_22483619_ChIP-Seq_HELA_Human0.78076394
86NANOG_16153702_ChIP-ChIP_HESCs_Human0.77366109
87KLF4_18555785_ChIP-Seq_MESCs_Mouse0.77216401
88SOX17_20123909_ChIP-Seq_XEN_Mouse0.76797634
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76290068
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.76078510
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75874871
92VDR_23849224_ChIP-Seq_CD4+_Human0.75843024
93NANOG_18555785_ChIP-Seq_MESCs_Mouse0.75760004
94ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.74138689
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74011687
96SOX9_26525672_Chip-Seq_HEART_Mouse0.73594928
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.72512831
98LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72095210
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71685436
100OCT4_20526341_ChIP-Seq_ESCs_Human0.69376011

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.81802025
2MP0005670_abnormal_white_adipose4.56781277
3MP0003183_abnormal_peptide_metabolism4.39817103
4MP0009384_cardiac_valve_regurgitation4.37969627
5MP0000516_abnormal_urinary_system4.28955864
6MP0005367_renal/urinary_system_phenotyp4.28955864
7MP0002736_abnormal_nociception_after4.13575234
8MP0005646_abnormal_pituitary_gland3.35730211
9MP0001661_extended_life_span2.69339459
10MP0003186_abnormal_redox_activity2.57451025
11MP0002938_white_spotting2.54781804
12MP0002396_abnormal_hematopoietic_system2.45719047
13MP0004147_increased_porphyrin_level2.42866483
14MP0005332_abnormal_amino_acid2.39062378
15MP0003705_abnormal_hypodermis_morpholog2.36936886
16MP0000013_abnormal_adipose_tissue2.24312802
17MP0008995_early_reproductive_senescence2.14502273
18MP0001968_abnormal_touch/_nociception2.13198517
19MP0004885_abnormal_endolymph2.08155072
20MP0008058_abnormal_DNA_repair2.07047535
21MP0002163_abnormal_gland_morphology1.98050844
22MP0004185_abnormal_adipocyte_glucose1.92756625
23MP0003806_abnormal_nucleotide_metabolis1.85898549
24MP0002139_abnormal_hepatobiliary_system1.82977138
25MP0010094_abnormal_chromosome_stability1.82141770
26MP0003880_abnormal_central_pattern1.80649786
27MP0000538_abnormal_urinary_bladder1.74390259
28MP0001764_abnormal_homeostasis1.64126961
29MP0000534_abnormal_ureter_morphology1.62643136
30MP0003693_abnormal_embryo_hatching1.62099444
31MP0009697_abnormal_copulation1.52026791
32MP0004264_abnormal_extraembryonic_tissu1.46381694
33MP0008872_abnormal_physiological_respon1.45215832
34MP0002127_abnormal_cardiovascular_syste1.35889813
35MP0004957_abnormal_blastocyst_morpholog1.33812067
36MP0003111_abnormal_nucleus_morphology1.30200617
37MP0005379_endocrine/exocrine_gland_phen1.26442514
38MP0008875_abnormal_xenobiotic_pharmacok1.26203017
39MP0003724_increased_susceptibility_to1.21628316
40MP0002735_abnormal_chemical_nociception1.18988474
41MP0005085_abnormal_gallbladder_physiolo1.17376412
42MP0006138_congestive_heart_failure1.15208299
43MP0003942_abnormal_urinary_system1.15033968
44MP0005319_abnormal_enzyme/_coenzyme1.14844179
45MP0003786_premature_aging1.13618173
46MP0001756_abnormal_urination1.13440512
47MP0005376_homeostasis/metabolism_phenot1.04099272
48MP0002837_dystrophic_cardiac_calcinosis1.03840313
49MP0000647_abnormal_sebaceous_gland0.98822769
50MP0002095_abnormal_skin_pigmentation0.97326694
51MP0002210_abnormal_sex_determination0.94942636
52MP0005551_abnormal_eye_electrophysiolog0.93529195
53MP0004043_abnormal_pH_regulation0.92245756
54MP0005423_abnormal_somatic_nervous0.90036823
55MP0003755_abnormal_palate_morphology0.89383710
56MP0000566_synostosis0.88953409
57MP0005253_abnormal_eye_physiology0.85700963
58MP0001905_abnormal_dopamine_level0.83546477
59MP0001145_abnormal_male_reproductive0.83094212
60MP0005164_abnormal_response_to0.82889011
61MP0003890_abnormal_embryonic-extraembry0.82394214
62MP0002132_abnormal_respiratory_system0.82344037
63MP0008569_lethality_at_weaning0.82195889
64MP0004130_abnormal_muscle_cell0.80847795
65MP0005365_abnormal_bile_salt0.80264366
66MP0006292_abnormal_olfactory_placode0.80020068
67MP0000653_abnormal_sex_gland0.79750968
68MP0010329_abnormal_lipoprotein_level0.79713218
69MP0000026_abnormal_inner_ear0.76393836
70MP0009643_abnormal_urine_homeostasis0.76194931
71MP0009250_abnormal_appendicular_skeleto0.75977122
72MP0005584_abnormal_enzyme/coenzyme_acti0.75799151
73MP0008873_increased_physiological_sensi0.75764878
74MP0001929_abnormal_gametogenesis0.74650295
75MP0001666_abnormal_nutrient_absorption0.74197832
76MP0005171_absent_coat_pigmentation0.72498606
77MP0002697_abnormal_eye_size0.71535169
78MP0005595_abnormal_vascular_smooth0.71338129
79MP0001119_abnormal_female_reproductive0.69868960
80MP0009115_abnormal_fat_cell0.68577636
81MP0002233_abnormal_nose_morphology0.67609751
82MP0004883_abnormal_blood_vessel0.67036945
83MP0005636_abnormal_mineral_homeostasis0.66308383
84MP0005330_cardiomyopathy0.65704614
85MP0008932_abnormal_embryonic_tissue0.65657998
86MP0004019_abnormal_vitamin_homeostasis0.65372103
87MP0003698_abnormal_male_reproductive0.64992742
88MP0004133_heterotaxia0.64086237
89MP0001486_abnormal_startle_reflex0.63769518
90MP0002069_abnormal_eating/drinking_beha0.63220326
91MP0002138_abnormal_hepatobiliary_system0.61779505
92MP0001286_abnormal_eye_development0.60110906
93MP0004233_abnormal_muscle_weight0.58078589
94MP0001340_abnormal_eyelid_morphology0.56731284
95MP0003936_abnormal_reproductive_system0.55899663
96MP0001986_abnormal_taste_sensitivity0.53581585
97MP0001919_abnormal_reproductive_system0.53507240
98MP0003077_abnormal_cell_cycle0.53402285
99MP0000747_muscle_weakness0.52573102
100MP0001963_abnormal_hearing_physiology0.48856965

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of alanine metabolism (HP:0010916)8.54381888
2Hyperalaninemia (HP:0003348)8.54381888
3Abnormality of pyruvate family amino acid metabolism (HP:0010915)8.54381888
4Esophageal varix (HP:0002040)5.20541165
5Constricted visual fields (HP:0001133)5.18687459
6Abnormality of the fetal cardiovascular system (HP:0010948)4.87290523
7Abnormal umbilical cord blood vessels (HP:0011403)4.87290523
8Single umbilical artery (HP:0001195)4.87290523
9Congenital sensorineural hearing impairment (HP:0008527)4.73566609
10Abnormality of serum amino acid levels (HP:0003112)4.67674406
11Spontaneous hematomas (HP:0007420)4.37801856
12Hyperglycinemia (HP:0002154)4.24626153
13Birth length less than 3rd percentile (HP:0003561)4.23757740
14Abnormality of homocysteine metabolism (HP:0010919)4.07114976
15Homocystinuria (HP:0002156)4.07114976
16Decreased electroretinogram (ERG) amplitude (HP:0000654)3.84087927
17White forelock (HP:0002211)3.79491368
18Generalized aminoaciduria (HP:0002909)3.53154206
19Abnormality of the umbilical cord (HP:0010881)3.48498302
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.46865599
21Patchy hypopigmentation of hair (HP:0011365)3.44486248
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.41002367
23Hypoalphalipoproteinemia (HP:0003233)3.36128294
24Conjunctival telangiectasia (HP:0000524)3.32560304
25Myocardial infarction (HP:0001658)3.24452608
26Conjugated hyperbilirubinemia (HP:0002908)2.94472542
27Nausea (HP:0002018)2.89423702
28Anorexia (HP:0002039)2.79510937
29Oligomenorrhea (HP:0000876)2.73979008
30Chromsome breakage (HP:0040012)2.70272349
31Action tremor (HP:0002345)2.67593460
32Abnormality of the vasculature of the conjunctiva (HP:0008054)2.60574390
33Arteriovenous malformation (HP:0100026)2.60554584
34Chorioretinal atrophy (HP:0000533)2.57789971
35Heterochromia iridis (HP:0001100)2.56721747
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.54906303
37Reduced subcutaneous adipose tissue (HP:0003758)2.54289576
38Abnormalities of placenta or umbilical cord (HP:0001194)2.52849810
39Pigmentary retinal degeneration (HP:0001146)2.45727005
40Biconcave vertebral bodies (HP:0004586)2.39260703
41Abnormality of the preputium (HP:0100587)2.39176088
42Abnormality of the carotid arteries (HP:0005344)2.38359685
43Proximal tubulopathy (HP:0000114)2.33954086
44Poor speech (HP:0002465)2.32004776
45Cortical visual impairment (HP:0100704)2.27801914
46Hypomagnesemia (HP:0002917)2.25089794
47Abnormality of serine family amino acid metabolism (HP:0010894)2.25035421
48Abnormality of glycine metabolism (HP:0010895)2.25035421
49Decreased subcutaneous fat (HP:0001002)2.24958169
50Toxemia of pregnancy (HP:0100603)2.22324455
51Hypoplastic left heart (HP:0004383)2.21167419
52Abnormality of pyrimidine metabolism (HP:0004353)2.20827787
53Abnormality of DNA repair (HP:0003254)2.20576912
54Meckel diverticulum (HP:0002245)2.17972168
55Abnormal lung lobation (HP:0002101)2.12671673
56Ileus (HP:0002595)2.11942154
57Abnormality of glycolysis (HP:0004366)2.10403776
58Bone marrow hypocellularity (HP:0005528)2.09286553
59Hypolipoproteinemia (HP:0010981)2.08640015
60Abnormality of the ileum (HP:0001549)2.07499181
61Cone-rod dystrophy (HP:0000548)2.07465506
62Increased serum pyruvate (HP:0003542)2.04600186
63Visceral angiomatosis (HP:0100761)2.02359757
64Diaphragmatic weakness (HP:0009113)2.01923514
65Renal tubular acidosis (HP:0001947)2.01315085
66Cavernous hemangioma (HP:0001048)1.99957867
67Duplicated collecting system (HP:0000081)1.99460004
68Pulmonary embolism (HP:0002204)1.99133124
69Attenuation of retinal blood vessels (HP:0007843)1.93853996
70Agnosia (HP:0010524)1.93846945
71Ependymoma (HP:0002888)1.93646519
72Abnormality of cochlea (HP:0000375)1.90084148
73Tetany (HP:0001281)1.87871813
74Maternal diabetes (HP:0009800)1.87595217
75Metabolic acidosis (HP:0001942)1.87386732
76Abnormality of methionine metabolism (HP:0010901)1.83539459
77Abnormality of the renal collecting system (HP:0004742)1.83135884
78Symptomatic seizures (HP:0011145)1.81731077
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81611158
80Abnormal tarsal ossification (HP:0008369)1.81342551
81Abnormality of subcutaneous fat tissue (HP:0001001)1.81051689
82Abnormality of magnesium homeostasis (HP:0004921)1.80777958
83Impaired vibration sensation in the lower limbs (HP:0002166)1.80179924
84Megaloblastic anemia (HP:0001889)1.78841405
85Myopathic facies (HP:0002058)1.76717177
86Hemangiomatosis (HP:0007461)1.71949930
87Thrombophlebitis (HP:0004418)1.71672115
88Chronic hepatic failure (HP:0100626)1.68410013
89Clonus (HP:0002169)1.68369936
90Paralysis (HP:0003470)1.67559729
91Hyperammonemia (HP:0001987)1.66473934
92Small intestinal stenosis (HP:0012848)1.66294174
93Duodenal stenosis (HP:0100867)1.66294174
94Hypoplastic heart (HP:0001961)1.63522739
95Ureteral duplication (HP:0000073)1.62822724
96Intrahepatic cholestasis (HP:0001406)1.61515109
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.60191215
98Ectopic anus (HP:0004397)1.59945629
99Elevated alkaline phosphatase (HP:0003155)1.58804620
100Hepatocellular carcinoma (HP:0001402)1.57160569

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K34.25884676
2PBK3.88964788
3CDC73.31636819
4RPS6KB23.26785702
5ZAK3.11911147
6MAP2K33.09796491
7CDK93.02695477
8CCNB12.79386964
9FGR2.79138770
10EPHA22.16761843
11ACVR1B2.10103650
12TLK12.00862054
13NTRK21.98214910
14JAK31.97729556
15VRK21.91624270
16TAF11.69646018
17VRK11.69566736
18STK391.66803276
19EIF2AK11.64846597
20DYRK21.53603360
21EIF2AK31.44413233
22CSNK1G31.41848931
23YES11.40383253
24SMG11.34676684
25WNK31.33898836
26BUB11.32661959
27FRK1.30736109
28EPHA41.29011560
29MAP4K21.28054485
30LMTK21.26136374
31EPHB21.22966812
32MKNK21.20685519
33AURKA1.20516489
34WEE11.11222832
35SGK2231.11103698
36SGK4941.11103698
37PKN11.10589347
38PAK41.09505825
39CSNK1G11.08039710
40MAP2K71.07959228
41PDK21.04716349
42NTRK31.03957521
43MAP2K11.00754355
44MST40.99739024
45CSNK1G20.98894800
46CAMK10.96163738
47PRKCI0.95342083
48BRSK10.95070864
49WNK40.94790675
50CSNK1A10.94313872
51CHEK20.93704810
52TNIK0.91909020
53OXSR10.89738587
54CAMK2G0.79120378
55PLK30.79112058
56SGK20.77729381
57ERBB40.72839446
58PLK10.72688714
59NUAK10.72676848
60AURKB0.71324370
61CAMK2B0.69341300
62CDK70.68811022
63MAP3K120.67221756
64MKNK10.67043205
65ATR0.66167562
66AKT20.64023962
67CAMK2D0.62503146
68ADRBK10.61581727
69MELK0.60329459
70NEK60.59235925
71CSNK1A1L0.57066481
72MAP3K110.53748735
73DAPK30.53135333
74TIE10.51721083
75PRKCD0.50819070
76SGK30.49736495
77PLK40.49221745
78RPS6KA50.48708664
79BCKDK0.47202830
80GRK10.43651684
81PRKCE0.42924825
82TAOK30.41886771
83ITK0.39808505
84NME10.39345406
85PLK20.39255250
86PIM10.38834992
87TSSK60.38752430
88EGFR0.38001582
89CSNK2A10.37743069
90RPS6KB10.37724950
91MAP3K80.37646164
92STK160.37342383
93PTK60.37339523
94STK40.35921998
95BRSK20.35720854
96INSR0.34866735
97CSNK2A20.33384299
98NEK10.31795518
99BMPR1B0.31403901
100PRKCA0.30854943

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006704.76127696
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.51250012
3Arginine biosynthesis_Homo sapiens_hsa002203.08505827
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.89658846
5Selenocompound metabolism_Homo sapiens_hsa004502.72941649
6Collecting duct acid secretion_Homo sapiens_hsa049662.71226604
7Sulfur metabolism_Homo sapiens_hsa009202.68747235
8Sulfur relay system_Homo sapiens_hsa041222.60745993
9Cysteine and methionine metabolism_Homo sapiens_hsa002702.30858457
10Proteasome_Homo sapiens_hsa030502.19530164
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04833689
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.03908860
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.92230287
14Base excision repair_Homo sapiens_hsa034101.91684810
15Biosynthesis of amino acids_Homo sapiens_hsa012301.88218970
16Alcoholism_Homo sapiens_hsa050341.86700863
17Fanconi anemia pathway_Homo sapiens_hsa034601.84465091
18DNA replication_Homo sapiens_hsa030301.79713526
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71933129
20Systemic lupus erythematosus_Homo sapiens_hsa053221.71257826
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69784632
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54504991
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46904318
24Mismatch repair_Homo sapiens_hsa034301.44007155
25Galactose metabolism_Homo sapiens_hsa000521.43181575
26Folate biosynthesis_Homo sapiens_hsa007901.39363501
27Nitrogen metabolism_Homo sapiens_hsa009101.34051806
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33839079
29Vitamin digestion and absorption_Homo sapiens_hsa049771.32938639
30Spliceosome_Homo sapiens_hsa030401.27083977
31Vibrio cholerae infection_Homo sapiens_hsa051101.24992850
32Steroid biosynthesis_Homo sapiens_hsa001001.23617310
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21345863
34Basal transcription factors_Homo sapiens_hsa030221.20737983
35Arginine and proline metabolism_Homo sapiens_hsa003301.18934084
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18198199
37Non-homologous end-joining_Homo sapiens_hsa034501.15306419
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.14771189
39Nucleotide excision repair_Homo sapiens_hsa034201.11572673
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09112816
41Glutathione metabolism_Homo sapiens_hsa004801.06052329
42GABAergic synapse_Homo sapiens_hsa047271.02332242
43Carbon metabolism_Homo sapiens_hsa012001.01852711
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.00975936
45Morphine addiction_Homo sapiens_hsa050320.97588694
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96251233
47Regulation of autophagy_Homo sapiens_hsa041400.95833585
48Fatty acid elongation_Homo sapiens_hsa000620.95256801
49Tryptophan metabolism_Homo sapiens_hsa003800.92835738
50Peroxisome_Homo sapiens_hsa041460.92143532
51Retinol metabolism_Homo sapiens_hsa008300.91921156
52Fat digestion and absorption_Homo sapiens_hsa049750.89036511
53mRNA surveillance pathway_Homo sapiens_hsa030150.88286569
54Fatty acid degradation_Homo sapiens_hsa000710.84858756
55Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84320811
56Nicotine addiction_Homo sapiens_hsa050330.83261148
57Homologous recombination_Homo sapiens_hsa034400.82391582
58Fatty acid metabolism_Homo sapiens_hsa012120.81716212
59beta-Alanine metabolism_Homo sapiens_hsa004100.81257510
60Propanoate metabolism_Homo sapiens_hsa006400.79059037
61Oxidative phosphorylation_Homo sapiens_hsa001900.77481571
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76883763
63Metabolic pathways_Homo sapiens_hsa011000.74510552
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74007356
65Fatty acid biosynthesis_Homo sapiens_hsa000610.73685281
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71994627
67Chemical carcinogenesis_Homo sapiens_hsa052040.71587690
68RNA transport_Homo sapiens_hsa030130.71171902
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70130356
70Synaptic vesicle cycle_Homo sapiens_hsa047210.69756708
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67707009
72Pyruvate metabolism_Homo sapiens_hsa006200.65461112
73Glycerolipid metabolism_Homo sapiens_hsa005610.63085195
74PPAR signaling pathway_Homo sapiens_hsa033200.62479249
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59891120
76Histidine metabolism_Homo sapiens_hsa003400.56954431
77RNA degradation_Homo sapiens_hsa030180.54063476
78Sphingolipid metabolism_Homo sapiens_hsa006000.53705008
79RNA polymerase_Homo sapiens_hsa030200.53227160
80Dopaminergic synapse_Homo sapiens_hsa047280.51953815
81Butanoate metabolism_Homo sapiens_hsa006500.51375424
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.51118825
83Glutamatergic synapse_Homo sapiens_hsa047240.50518902
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.48625990
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48506423
86Starch and sucrose metabolism_Homo sapiens_hsa005000.48018368
87Phenylalanine metabolism_Homo sapiens_hsa003600.47238254
88Pyrimidine metabolism_Homo sapiens_hsa002400.47027131
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45245276
90Purine metabolism_Homo sapiens_hsa002300.42850401
91Serotonergic synapse_Homo sapiens_hsa047260.42264250
92Cell cycle_Homo sapiens_hsa041100.39851938
93Circadian entrainment_Homo sapiens_hsa047130.38790703
94Pancreatic secretion_Homo sapiens_hsa049720.37735199
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36981564
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35556705
97Ether lipid metabolism_Homo sapiens_hsa005650.33747946
98Pentose phosphate pathway_Homo sapiens_hsa000300.32236057
99Tyrosine metabolism_Homo sapiens_hsa003500.30446883
100Thyroid cancer_Homo sapiens_hsa052160.29904655

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