ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of gonadotropin secretion (GO:0032276)	7.82166666
2	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.37428705
3	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.37428705
4	homocysteine metabolic process (GO:0050667)	6.09106329
5	folic acid-containing compound biosynthetic process (GO:0009396)	5.49428318
6	proteasome assembly (GO:0043248)	5.38532584
7	mitochondrial RNA metabolic process (GO:0000959)	5.37492680
8	positive regulation of growth hormone secretion (GO:0060124)	4.92598506
9	regulation of plasminogen activation (GO:0010755)	4.87490037
10	desmosome organization (GO:0002934)	4.51331704
11	galactose catabolic process (GO:0019388)	4.48152502
12	pteridine-containing compound biosynthetic process (GO:0042559)	4.39032993
13	adenosine metabolic process (GO:0046085)	4.23529290
14	ribosome biogenesis (GO:0042254)	4.20680114
15	cysteine metabolic process (GO:0006534)	4.20664628
16	purine nucleotide salvage (GO:0032261)	4.18299953
17	L-serine metabolic process (GO:0006563)	4.18192058
18	chaperone-mediated protein transport (GO:0072321)	4.11654446
19	rRNA methylation (GO:0031167)	4.02278027
20	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.96522552
21	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.96522552
22	NADH dehydrogenase complex assembly (GO:0010257)	3.96522552
23	DNA replication-dependent nucleosome assembly (GO:0006335)	3.95296963
24	DNA replication-dependent nucleosome organization (GO:0034723)	3.95296963
25	rRNA modification (GO:0000154)	3.93977322
26	negative regulation of Ras GTPase activity (GO:0034261)	3.91482665
27	sulfur amino acid catabolic process (GO:0000098)	3.88694454
28	negative regulation of DNA biosynthetic process (GO:2000279)	3.81925652
29	pseudouridine synthesis (GO:0001522)	3.78922378
30	CENP-A containing nucleosome assembly (GO:0034080)	3.75493022
31	inner mitochondrial membrane organization (GO:0007007)	3.69794734
32	protein complex biogenesis (GO:0070271)	3.67717734
33	negative regulation of keratinocyte proliferation (GO:0010839)	3.67532992
34	galactose metabolic process (GO:0006012)	3.62281087
35	IMP biosynthetic process (GO:0006188)	3.49113685
36	chromatin remodeling at centromere (GO:0031055)	3.47888508
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47821051
38	tRNA modification (GO:0006400)	3.41455794
39	tRNA processing (GO:0008033)	3.38457202
40	cullin deneddylation (GO:0010388)	3.37865033
41	microtubule nucleation (GO:0007020)	3.35891241
42	protein deneddylation (GO:0000338)	3.35243385
43	regulation of growth hormone secretion (GO:0060123)	3.33957714
44	cellular component biogenesis (GO:0044085)	3.33299465
45	ribonucleoprotein complex biogenesis (GO:0022613)	3.30146343
46	aminoglycoside antibiotic metabolic process (GO:0030647)	3.28763519
47	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.27682955
48	serine family amino acid biosynthetic process (GO:0009070)	3.25445776
49	tetrahydrofolate metabolic process (GO:0046653)	3.23634505
50	folic acid-containing compound metabolic process (GO:0006760)	3.21750964
51	transcription from mitochondrial promoter (GO:0006390)	3.21723168
52	DNA damage response, detection of DNA damage (GO:0042769)	3.21440751
53	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.18371140
54	sulfur amino acid biosynthetic process (GO:0000097)	3.16949429
55	hepatocyte apoptotic process (GO:0097284)	3.15698105
56	nucleoside transmembrane transport (GO:1901642)	3.14843170
57	cochlea development (GO:0090102)	3.07448222
58	artery smooth muscle contraction (GO:0014824)	3.04619449
59	protein targeting to mitochondrion (GO:0006626)	3.01573979
60	white fat cell differentiation (GO:0050872)	3.01059686
61	protein-cofactor linkage (GO:0018065)	2.96641864
62	pteridine-containing compound metabolic process (GO:0042558)	2.93556862
63	vascular smooth muscle contraction (GO:0014829)	2.93221918
64	keratinocyte development (GO:0003334)	2.93055247
65	primary amino compound metabolic process (GO:1901160)	2.91649114
66	nucleotide salvage (GO:0043173)	2.90722931
67	DNA replication checkpoint (GO:0000076)	2.90685629
68	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.90218877
69	positive regulation of endothelial cell differentiation (GO:0045603)	2.90176991
70	histone exchange (GO:0043486)	2.88330530
71	alternative mRNA splicing, via spliceosome (GO:0000380)	2.88203912
72	protein K6-linked ubiquitination (GO:0085020)	2.83960523
73	regulation of mitochondrial translation (GO:0070129)	2.82199137
74	folic acid metabolic process (GO:0046655)	2.81572351
75	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-	2.80565761
76	inner ear receptor cell development (GO:0060119)	2.78598233
77	ribosome assembly (GO:0042255)	2.78495270
78	tRNA metabolic process (GO:0006399)	2.74909474
79	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.73861977
80	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.72797787
81	rRNA processing (GO:0006364)	2.72355124
82	nucleoside transport (GO:0015858)	2.71590562
83	purine-containing compound salvage (GO:0043101)	2.71573230
84	ribosomal small subunit assembly (GO:0000028)	2.70377898
85	DNA replication-independent nucleosome organization (GO:0034724)	2.70175791
86	DNA replication-independent nucleosome assembly (GO:0006336)	2.70175791
87	regulation of tight junction assembly (GO:2000810)	2.69479306
88	protein localization to mitochondrion (GO:0070585)	2.67431929
89	L-methionine salvage (GO:0071267)	2.67232497
90	L-methionine biosynthetic process (GO:0071265)	2.67232497
91	amino acid salvage (GO:0043102)	2.67232497
92	establishment of protein localization to mitochondrion (GO:0072655)	2.67085536
93	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.65110064
94	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.65096087
95	IMP metabolic process (GO:0046040)	2.64393612
96	purine nucleobase biosynthetic process (GO:0009113)	2.64354023
97	respiratory chain complex IV assembly (GO:0008535)	2.62871120
98	negative regulation of stem cell proliferation (GO:2000647)	2.62860423
99	phosphate ion homeostasis (GO:0055062)	2.62833562
100	trivalent inorganic anion homeostasis (GO:0072506)	2.62833562

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.36432276
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.08171108
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.95527148
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.68345159
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.45603554
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.19622722
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.97828262
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.76747780
9	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.76638623
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75881007
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.74618966
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.67538869
13	E2F7_22180533_ChIP-Seq_HELA_Human	2.66407446
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.56775935
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.50407967
16	AR_21909140_ChIP-Seq_LNCAP_Human	2.48846473
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.47942142
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.47643304
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.37686513
20	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.36375296
21	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.35481053
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.28756132
23	IRF1_19129219_ChIP-ChIP_H3396_Human	2.19330475
24	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.15597861
25	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11103425
26	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.99736406
27	VDR_22108803_ChIP-Seq_LS180_Human	1.99325471
28	GABP_19822575_ChIP-Seq_HepG2_Human	1.97625586
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92121251
30	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.91331899
31	DCP1A_22483619_ChIP-Seq_HELA_Human	1.86988112
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.82093771
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.66791107
34	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.65511408
35	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.61843756
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60045903
37	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.59180305
38	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.55203232
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.53406146
40	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.52992724
41	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51917325
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.50481912
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.48987133
44	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.48761999
45	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.46489474
46	TTF2_22483619_ChIP-Seq_HELA_Human	1.45747219
47	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.39484098
48	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.36926363
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36015669
50	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31581825
51	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.30607379
52	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.27958121
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.23924627
54	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.22758720
55	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.20049415
56	ZNF263_19887448_ChIP-Seq_K562_Human	1.19820974
57	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.18439328
58	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.17477853
59	ZNF274_21170338_ChIP-Seq_K562_Hela	1.15439372
60	GATA4_25053715_ChIP-Seq_YYC3_Human	1.14869300
61	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.13490475
62	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.13031789
63	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.12385067
64	NCOR_22424771_ChIP-Seq_293T_Human	1.12024927
65	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.10767648
66	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.10140552
67	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.08879400
68	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.08543849
69	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06747203
70	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.06573554
71	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.06295124
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.05415959
73	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.04606315
74	KDM5A_27292631_Chip-Seq_BREAST_Human	1.04323971
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01817864
76	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.01715519
77	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.01415010
78	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99056628
79	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.96345283
80	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.92111000
81	EOMES_21245162_ChIP-Seq_HESCs_Human	0.89713450
82	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.89188072
83	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	0.87328462
84	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.87305612
85	TP53_22573176_ChIP-Seq_HFKS_Human	0.85921605
86	P300_27268052_Chip-Seq_Bcells_Human	0.84196086
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.82006919
88	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.80668987
89	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.79716350
90	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.78997923
91	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.78057194
92	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.77073774
93	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.76947512
94	CDX2_22108803_ChIP-Seq_LS180_Human	0.75960209
95	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.75206717
96	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.74108918
97	ATF3_27146783_Chip-Seq_COLON_Human	0.72073025
98	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.72030231
99	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.70725156
100	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.69722041

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	7.35829398
2	MP0005379_endocrine/exocrine_gland_phen	4.25099590
3	MP0003806_abnormal_nucleotide_metabolis	3.80718265
4	MP0005360_urolithiasis	3.48263703
5	MP0000647_abnormal_sebaceous_gland	3.30822802
6	MP0005670_abnormal_white_adipose	3.09408985
7	MP0008058_abnormal_DNA_repair	2.64697111
8	MP0003950_abnormal_plasma_membrane	2.45855927
9	MP0005646_abnormal_pituitary_gland	2.42520322
10	MP0003693_abnormal_embryo_hatching	2.42144949
11	MP0006292_abnormal_olfactory_placode	2.04261942
12	MP0008872_abnormal_physiological_respon	2.01478575
13	MP0003786_premature_aging	1.98672405
14	MP0002736_abnormal_nociception_after	1.97718146
15	MP0004147_increased_porphyrin_level	1.93126193
16	MP0008995_early_reproductive_senescence	1.91235188
17	MP0010094_abnormal_chromosome_stability	1.89494070
18	MP0002938_white_spotting	1.83469402
19	MP0003119_abnormal_digestive_system	1.78627024
20	MP0002132_abnormal_respiratory_system	1.77052591
21	MP0010234_abnormal_vibrissa_follicle	1.75445710
22	MP0000613_abnormal_salivary_gland	1.72755321
23	MP0003183_abnormal_peptide_metabolism	1.71952859
24	MP0004019_abnormal_vitamin_homeostasis	1.70739040
25	MP0000013_abnormal_adipose_tissue	1.68423467
26	MP0000516_abnormal_urinary_system	1.66907694
27	MP0005367_renal/urinary_system_phenotyp	1.66907694
28	MP0004264_abnormal_extraembryonic_tissu	1.65676512
29	MP0003123_paternal_imprinting	1.61859001
30	MP0001764_abnormal_homeostasis	1.58035655
31	MP0003111_abnormal_nucleus_morphology	1.57480730
32	MP0009379_abnormal_foot_pigmentation	1.54475687
33	MP0005084_abnormal_gallbladder_morpholo	1.52963091
34	MP0006072_abnormal_retinal_apoptosis	1.50729392
35	MP0009697_abnormal_copulation	1.46426212
36	MP0003186_abnormal_redox_activity	1.44031120
37	MP0004957_abnormal_blastocyst_morpholog	1.38235603
38	MP0002210_abnormal_sex_determination	1.33507566
39	MP0003936_abnormal_reproductive_system	1.33239318
40	MP0003718_maternal_effect	1.31230457
41	MP0002160_abnormal_reproductive_system	1.30796046
42	MP0002138_abnormal_hepatobiliary_system	1.29951247
43	MP0000427_abnormal_hair_cycle	1.26574892
44	MP0005410_abnormal_fertilization	1.26110170
45	MP0001968_abnormal_touch/_nociception	1.24711884
46	MP0006276_abnormal_autonomic_nervous	1.24261554
47	MP0001348_abnormal_lacrimal_gland	1.15952857
48	MP0003077_abnormal_cell_cycle	1.13045934
49	MP0001756_abnormal_urination	1.13005564
50	MP0001661_extended_life_span	1.07124804
51	MP0001929_abnormal_gametogenesis	1.05605819
52	MP0002396_abnormal_hematopoietic_system	1.05262655
53	MP0008875_abnormal_xenobiotic_pharmacok	1.01305304
54	MP0000678_abnormal_parathyroid_gland	1.00640196
55	MP0000653_abnormal_sex_gland	1.00286777
56	MP0005332_abnormal_amino_acid	0.99023075
57	MP0008932_abnormal_embryonic_tissue	0.98704937
58	MP0002098_abnormal_vibrissa_morphology	0.98205643
59	MP0000467_abnormal_esophagus_morphology	0.97849010
60	MP0010352_gastrointestinal_tract_polyps	0.95576259
61	MP0005551_abnormal_eye_electrophysiolog	0.94483445
62	MP0003567_abnormal_fetal_cardiomyocyte	0.94265154
63	MP0009643_abnormal_urine_homeostasis	0.93501238
64	MP0001666_abnormal_nutrient_absorption	0.92869499
65	MP0003890_abnormal_embryonic-extraembry	0.92221735
66	MP0010678_abnormal_skin_adnexa	0.86665278
67	MP0002277_abnormal_respiratory_mucosa	0.84406627
68	MP0003787_abnormal_imprinting	0.82515562
69	MP0003941_abnormal_skin_development	0.82290975
70	MP0001145_abnormal_male_reproductive	0.82226488
71	MP0008877_abnormal_DNA_methylation	0.81269598
72	MP0000639_abnormal_adrenal_gland	0.81089884
73	MP0000534_abnormal_ureter_morphology	0.80680403
74	MP0003315_abnormal_perineum_morphology	0.80298337
75	MP0001986_abnormal_taste_sensitivity	0.79882086
76	MP0003937_abnormal_limbs/digits/tail_de	0.77973624
77	MP0002095_abnormal_skin_pigmentation	0.77665124
78	MP0006035_abnormal_mitochondrial_morpho	0.75506022
79	MP0003942_abnormal_urinary_system	0.75375309
80	MP0003705_abnormal_hypodermis_morpholog	0.74983311
81	MP0000383_abnormal_hair_follicle	0.74461833
82	MP0002796_impaired_skin_barrier	0.73932181
83	MP0000462_abnormal_digestive_system	0.71742160
84	MP0001286_abnormal_eye_development	0.71470396
85	MP0004233_abnormal_muscle_weight	0.70947010
86	MP0000538_abnormal_urinary_bladder	0.68666260
87	MP0000579_abnormal_nail_morphology	0.68503106
88	MP0001730_embryonic_growth_arrest	0.68351425
89	MP0005365_abnormal_bile_salt	0.67921036
90	MP0003638_abnormal_response/metabolism_	0.67060308
91	MP0000627_abnormal_mammary_gland	0.66502835
92	MP0005253_abnormal_eye_physiology	0.66347289
93	MP0003868_abnormal_feces_composition	0.65886255
94	MP0000762_abnormal_tongue_morphology	0.65791214
95	MP0005377_hearing/vestibular/ear_phenot	0.65762236
96	MP0003878_abnormal_ear_physiology	0.65762236
97	MP0000749_muscle_degeneration	0.64818725
98	MP0004885_abnormal_endolymph	0.64569191
99	MP0001119_abnormal_female_reproductive	0.62825888
100	MP0000377_abnormal_hair_follicle	0.62671185

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	6.71492284
2	Hyperalaninemia (HP:0003348)	6.71492284
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	6.71492284
4	Constricted visual fields (HP:0001133)	4.58349769
5	Birth length less than 3rd percentile (HP:0003561)	4.02990501
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.80973629
7	Congenital sensorineural hearing impairment (HP:0008527)	3.75270288
8	Abnormal umbilical cord blood vessels (HP:0011403)	3.47967686
9	Single umbilical artery (HP:0001195)	3.47967686
10	Abnormality of the fetal cardiovascular system (HP:0010948)	3.47967686
11	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.40664883
12	Abnormality of serum amino acid levels (HP:0003112)	3.39514041
13	Brittle hair (HP:0002299)	3.27246490
14	Esophageal varix (HP:0002040)	3.26282238
15	White forelock (HP:0002211)	3.15271139
16	Ileus (HP:0002595)	3.13989752
17	Patchy hypopigmentation of hair (HP:0011365)	3.13605223
18	Acute necrotizing encephalopathy (HP:0006965)	3.03113106
19	Homocystinuria (HP:0002156)	2.98216120
20	Abnormality of homocysteine metabolism (HP:0010919)	2.98216120
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.88127865
22	Adrenal hypoplasia (HP:0000835)	2.88011022
23	Hyperglycinemia (HP:0002154)	2.85516395
24	Abnormality of methionine metabolism (HP:0010901)	2.83763038
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.81181957
26	Acute encephalopathy (HP:0006846)	2.80893749
27	Chorioretinal atrophy (HP:0000533)	2.78864201
28	Short tibia (HP:0005736)	2.78715452
29	Premature ovarian failure (HP:0008209)	2.77471392
30	Metaphyseal dysplasia (HP:0100255)	2.69939702
31	Abnormality of the umbilical cord (HP:0010881)	2.66775234
32	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64990964
33	Mitochondrial inheritance (HP:0001427)	2.54025937
34	Lactic acidosis (HP:0003128)	2.52513410
35	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.51275011
36	Decreased subcutaneous fat (HP:0001002)	2.50010184
37	Increased CSF lactate (HP:0002490)	2.49704145
38	Stenosis of the external auditory canal (HP:0000402)	2.46653449
39	Cerebral edema (HP:0002181)	2.45199474
40	Reduced subcutaneous adipose tissue (HP:0003758)	2.43937207
41	Neoplasm of the adrenal cortex (HP:0100641)	2.40643440
42	Increased serum lactate (HP:0002151)	2.39392077
43	Poor speech (HP:0002465)	2.38263189
44	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.36409099
45	Conjugated hyperbilirubinemia (HP:0002908)	2.35052351
46	Progressive macrocephaly (HP:0004481)	2.31866477
47	Pendular nystagmus (HP:0012043)	2.25522849
48	Abnormal pupillary function (HP:0007686)	2.24231283
49	Intrahepatic cholestasis (HP:0001406)	2.24064256
50	Hypoalphalipoproteinemia (HP:0003233)	2.22713542
51	Hypotrichosis (HP:0001006)	2.20159404
52	Lethargy (HP:0001254)	2.18713040
53	Hyperphosphaturia (HP:0003109)	2.12091536
54	Reticulocytopenia (HP:0001896)	2.11765139
55	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.11343804
56	Gastrointestinal dysmotility (HP:0002579)	2.10906476
57	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.09847766
58	Congenital ichthyosiform erythroderma (HP:0007431)	2.07742585
59	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.07014455
60	Short 1st metacarpal (HP:0010034)	2.07014455
61	Proximal tubulopathy (HP:0000114)	2.05264873
62	Generalized aminoaciduria (HP:0002909)	2.04687891
63	Tetany (HP:0001281)	2.01913574
64	Abnormality of subcutaneous fat tissue (HP:0001001)	2.01126898
65	Abolished electroretinogram (ERG) (HP:0000550)	2.00137904
66	Methylmalonic acidemia (HP:0002912)	1.98345717
67	Increased hepatocellular lipid droplets (HP:0006565)	1.98084359
68	Increased serum pyruvate (HP:0003542)	1.97956683
69	Abnormality of urine glucose concentration (HP:0011016)	1.97589425
70	Glycosuria (HP:0003076)	1.97589425
71	Cerebral hypomyelination (HP:0006808)	1.96822515
72	Chromsome breakage (HP:0040012)	1.95647135
73	Rectal prolapse (HP:0002035)	1.94858108
74	Nausea (HP:0002018)	1.93941801
75	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.93636455
76	Abnormal pancreas size (HP:0012094)	1.92127983
77	Hyperphosphatemia (HP:0002905)	1.91980490
78	Abnormality of glycolysis (HP:0004366)	1.91507975
79	Median cleft lip (HP:0000161)	1.90791828
80	Lipid accumulation in hepatocytes (HP:0006561)	1.90755490
81	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.87781947
82	Microretrognathia (HP:0000308)	1.85045042
83	Methylmalonic aciduria (HP:0012120)	1.84539797
84	Abnormalities of placenta or umbilical cord (HP:0001194)	1.83514023
85	Hepatocellular necrosis (HP:0001404)	1.83489938
86	Myocardial infarction (HP:0001658)	1.83079031
87	Abnormality of the 1st metacarpal (HP:0010009)	1.83066355
88	Abnormality of magnesium homeostasis (HP:0004921)	1.82770971
89	Exercise intolerance (HP:0003546)	1.82020148
90	Attenuation of retinal blood vessels (HP:0007843)	1.81781100
91	Abnormality of glycine metabolism (HP:0010895)	1.80491959
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80491959
93	Neoplasm of the adrenal gland (HP:0100631)	1.80162356
94	Hypercalciuria (HP:0002150)	1.77675058
95	Hypoplastic left heart (HP:0004383)	1.76380319
96	Premature graying of hair (HP:0002216)	1.76022600
97	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	1.72558764
98	Hypoparathyroidism (HP:0000829)	1.70253491
99	Oligomenorrhea (HP:0000876)	1.69269816
100	Colon cancer (HP:0003003)	1.67517086

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	5.20777724
2	TLK1	4.17272663
3	LMTK2	3.88910172
4	EPHA2	3.63849481
5	BUB1	3.29636308
6	PDK2	3.18415882
7	VRK2	2.78350816
8	VRK1	2.38994438
9	STK16	2.35230552
10	MST1R	2.33067802
11	PBK	2.30730596
12	RPS6KB2	2.16009867
13	MAP3K3	2.15597154
14	ACVR1B	2.09809747
15	NEK1	2.08845514
16	STK39	1.99451520
17	MUSK	1.91264391
18	EIF2AK1	1.75930401
19	MST4	1.70599769
20	MAP2K3	1.67534860
21	AURKA	1.67514476
22	CDK9	1.55843519
23	MAP3K12	1.51899304
24	EIF2AK3	1.51435101
25	NME2	1.47860468
26	LIMK1	1.40979286
27	WNK4	1.35010145
28	FRK	1.30033193
29	OXSR1	1.30029933
30	CDC7	1.29810160
31	BCKDK	1.22353882
32	MINK1	1.20815912
33	PLK4	1.20480824
34	PAK4	1.16694872
35	MYLK	1.12163033
36	TNIK	0.98487316
37	AURKB	0.94892720
38	NUAK1	0.92039036
39	PLK1	0.90458064
40	BMPR1B	0.90438693
41	CHEK2	0.89684886
42	DAPK3	0.88745675
43	SRPK1	0.87706813
44	ILK	0.86069938
45	ABL2	0.83699753
46	MET	0.80240793
47	SMG1	0.79128429
48	STK10	0.78179847
49	GRK1	0.76445256
50	TRIM28	0.75207170
51	PRKG2	0.73573532
52	MAP2K7	0.71072221
53	NTRK3	0.66441024
54	PIK3CA	0.66130003
55	NME1	0.65163353
56	TESK1	0.64329016
57	CDK19	0.62504799
58	MAP2K1	0.61279313
59	ARAF	0.60154515
60	PKN1	0.59186591
61	FGR	0.58871425
62	AKT2	0.56457760
63	DYRK2	0.55015847
64	ADRBK1	0.54043925
65	PAK1	0.53746492
66	PLK3	0.53184884
67	RPS6KA5	0.51648595
68	EPHB2	0.51491242
69	CAMK2D	0.50268702
70	PRKCI	0.49490929
71	STK38L	0.49136342
72	EIF2AK2	0.48873262
73	JAK3	0.47038698
74	CAMK2G	0.46543264
75	NEK6	0.43717670
76	ERBB4	0.43177452
77	NTRK2	0.42258733
78	SGK223	0.41456902
79	SGK494	0.41456902
80	PIM2	0.40104004
81	PRKCD	0.39877083
82	PTK6	0.39797505
83	CHEK1	0.39005931
84	CAMK1	0.39000130
85	PTK2	0.38357323
86	DAPK1	0.37428559
87	CSNK1A1	0.36739472
88	TTK	0.36016908
89	TESK2	0.35720564
90	CSNK1G3	0.34780859
91	PRKCE	0.34136767
92	CAMK2B	0.33865869
93	CSNK2A1	0.33305878
94	MAP3K8	0.31753779
95	MAP2K2	0.31432036
96	CDK7	0.30976654
97	CCNB1	0.30089561
98	ROCK1	0.29454940
99	CSNK1G1	0.27591208
100	TSSK6	0.27068570

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.36989639
2	One carbon pool by folate_Homo sapiens_hsa00670	3.01958719
3	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.78525649
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.68339526
5	Ribosome_Homo sapiens_hsa03010	2.51588925
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.41072820
7	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36265715
8	Sulfur relay system_Homo sapiens_hsa04122	2.26176309
9	Selenocompound metabolism_Homo sapiens_hsa00450	2.24878964
10	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.22482947
11	Mismatch repair_Homo sapiens_hsa03430	2.16345983
12	Vibrio cholerae infection_Homo sapiens_hsa05110	2.00963825
13	Sulfur metabolism_Homo sapiens_hsa00920	1.99097993
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.96580730
15	DNA replication_Homo sapiens_hsa03030	1.92513942
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.89670686
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.87861903
18	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.73181271
19	RNA polymerase_Homo sapiens_hsa03020	1.72684234
20	Parkinsons disease_Homo sapiens_hsa05012	1.71598444
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.68443668
22	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.55709100
23	Basal transcription factors_Homo sapiens_hsa03022	1.55568138
24	Galactose metabolism_Homo sapiens_hsa00052	1.55242229
25	RNA transport_Homo sapiens_hsa03013	1.55007869
26	Base excision repair_Homo sapiens_hsa03410	1.51857038
27	Spliceosome_Homo sapiens_hsa03040	1.49569738
28	Homologous recombination_Homo sapiens_hsa03440	1.44716087
29	Huntingtons disease_Homo sapiens_hsa05016	1.44254862
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.44097800
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.41205041
32	Pyrimidine metabolism_Homo sapiens_hsa00240	1.37164300
33	Folate biosynthesis_Homo sapiens_hsa00790	1.36308072
34	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.26576883
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26235340
36	Tryptophan metabolism_Homo sapiens_hsa00380	1.25728820
37	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.25705759
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.24105301
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.23674767
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.23583412
41	Alcoholism_Homo sapiens_hsa05034	1.19631249
42	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.17055547
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.14195497
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.09629438
45	Fatty acid elongation_Homo sapiens_hsa00062	1.05522813
46	Butanoate metabolism_Homo sapiens_hsa00650	1.05068047
47	RNA degradation_Homo sapiens_hsa03018	1.04610778
48	Glutathione metabolism_Homo sapiens_hsa00480	1.02580637
49	Fanconi anemia pathway_Homo sapiens_hsa03460	1.01535665
50	Pyruvate metabolism_Homo sapiens_hsa00620	0.98416286
51	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.93228455
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92040951
53	Purine metabolism_Homo sapiens_hsa00230	0.89723312
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89124440
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87832580
56	Alzheimers disease_Homo sapiens_hsa05010	0.85866413
57	Protein export_Homo sapiens_hsa03060	0.85628403
58	Carbon metabolism_Homo sapiens_hsa01200	0.85204380
59	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.84696601
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83722156
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83714374
62	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.83636175
63	Retinol metabolism_Homo sapiens_hsa00830	0.83367287
64	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79553022
65	Peroxisome_Homo sapiens_hsa04146	0.79493714
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78501659
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78009269
68	Metabolic pathways_Homo sapiens_hsa01100	0.76531712
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73819729
70	Thyroid cancer_Homo sapiens_hsa05216	0.73345923
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.72734708
72	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70657586
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.69386328
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66591994
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.64698931
76	mRNA surveillance pathway_Homo sapiens_hsa03015	0.63455197
77	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.61882302
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61565504
79	Cell cycle_Homo sapiens_hsa04110	0.58887256
80	Propanoate metabolism_Homo sapiens_hsa00640	0.57147918
81	Tight junction_Homo sapiens_hsa04530	0.54707263
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.52419545
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.48153229
84	Phenylalanine metabolism_Homo sapiens_hsa00360	0.47364470
85	Fatty acid degradation_Homo sapiens_hsa00071	0.46874681
86	Hippo signaling pathway_Homo sapiens_hsa04390	0.46215158
87	Caffeine metabolism_Homo sapiens_hsa00232	0.45749294
88	Bile secretion_Homo sapiens_hsa04976	0.43317897
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.42167449
90	GABAergic synapse_Homo sapiens_hsa04727	0.41447517
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41435511
92	Phototransduction_Homo sapiens_hsa04744	0.40787236
93	Pentose phosphate pathway_Homo sapiens_hsa00030	0.39328264
94	Cardiac muscle contraction_Homo sapiens_hsa04260	0.39276888
95	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.39274802
96	Nicotine addiction_Homo sapiens_hsa05033	0.38501980
97	Regulation of autophagy_Homo sapiens_hsa04140	0.36731460
98	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36592803
99	Tyrosine metabolism_Homo sapiens_hsa00350	0.33231865
100	Olfactory transduction_Homo sapiens_hsa04740	0.33124302

KRT18P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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