KRT18P17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gonadal mesoderm development (GO:0007506)6.72679031
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.47915336
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13244826
4ATP synthesis coupled proton transport (GO:0015986)5.13244826
5proteasome assembly (GO:0043248)5.01803969
6rRNA modification (GO:0000154)4.79891912
7maturation of SSU-rRNA (GO:0030490)4.65584236
8rRNA methylation (GO:0031167)4.65222664
9ribosomal small subunit assembly (GO:0000028)4.63013243
10viral transcription (GO:0019083)4.57272462
11translational termination (GO:0006415)4.55050527
12ribosomal small subunit biogenesis (GO:0042274)4.42929397
13hepatocyte apoptotic process (GO:0097284)4.42438533
14chaperone-mediated protein transport (GO:0072321)4.19490606
15ribosome assembly (GO:0042255)4.19001950
16ribosomal large subunit biogenesis (GO:0042273)4.17920435
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13088185
18regulation of cellular respiration (GO:0043457)4.09025124
19respiratory electron transport chain (GO:0022904)4.07932281
20single strand break repair (GO:0000012)4.04471136
21electron transport chain (GO:0022900)4.00122138
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.99518623
23regulation of oxidative phosphorylation (GO:0002082)3.95122947
24translational elongation (GO:0006414)3.93342735
25cotranslational protein targeting to membrane (GO:0006613)3.91148858
26protein targeting to ER (GO:0045047)3.86417574
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.73131841
28translation (GO:0006412)3.72553159
29establishment of protein localization to mitochondrial membrane (GO:0090151)3.71360885
30protein localization to endoplasmic reticulum (GO:0070972)3.71190504
31regulation of mitochondrial translation (GO:0070129)3.60420529
32cellular protein complex disassembly (GO:0043624)3.58768339
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.58736512
34translational initiation (GO:0006413)3.56179654
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.53155353
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.53155353
37viral life cycle (GO:0019058)3.47801081
38hydrogen ion transmembrane transport (GO:1902600)3.33393842
39regulation of centriole replication (GO:0046599)3.33158750
40negative regulation of complement activation (GO:0045916)3.32461815
41prostanoid biosynthetic process (GO:0046457)3.25390009
42prostaglandin biosynthetic process (GO:0001516)3.25390009
43intestinal epithelial cell development (GO:0060576)3.23981550
44negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.23551393
45ATP biosynthetic process (GO:0006754)3.22399308
46ribonucleoprotein complex biogenesis (GO:0022613)3.17770337
47regulation of cellular amino acid metabolic process (GO:0006521)3.16912030
48DNA replication checkpoint (GO:0000076)3.16880057
49histone mRNA metabolic process (GO:0008334)3.16183944
50exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.14833274
51fusion of sperm to egg plasma membrane (GO:0007342)3.14438378
52purine nucleoside triphosphate biosynthetic process (GO:0009145)3.13301515
53rRNA processing (GO:0006364)3.10932772
54purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09824824
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.09724896
56positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08215814
57protein complex disassembly (GO:0043241)3.05271461
58sperm motility (GO:0030317)3.04158339
59galactose catabolic process (GO:0019388)3.03683282
60ATP hydrolysis coupled proton transport (GO:0015991)2.99519511
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99519511
62spliceosomal complex assembly (GO:0000245)2.99510718
63rRNA metabolic process (GO:0016072)2.97225671
64artery smooth muscle contraction (GO:0014824)2.96526568
65mitotic metaphase plate congression (GO:0007080)2.95010795
66spliceosomal snRNP assembly (GO:0000387)2.94966646
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.94556111
68negative regulation of ligase activity (GO:0051352)2.94556111
69cellular component biogenesis (GO:0044085)2.94167106
70protein targeting to mitochondrion (GO:0006626)2.93808116
71macromolecular complex disassembly (GO:0032984)2.92110125
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91012600
73peptidyl-histidine modification (GO:0018202)2.90361893
74pyrimidine-containing compound transmembrane transport (GO:0072531)2.90024597
75protein targeting to membrane (GO:0006612)2.87582201
76proton transport (GO:0015992)2.87063519
77negative regulation of protein activation cascade (GO:2000258)2.85956773
78regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.85634510
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84692332
80oxidative phosphorylation (GO:0006119)2.83737993
81protein localization to mitochondrion (GO:0070585)2.83366662
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82729257
83nuclear-transcribed mRNA catabolic process (GO:0000956)2.81141292
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.80392541
85hydrogen transport (GO:0006818)2.79851399
86ribonucleoside triphosphate biosynthetic process (GO:0009201)2.79285965
87intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77761445
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77761445
89DNA damage response, detection of DNA damage (GO:0042769)2.75861329
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74303586
91signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74303586
92signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74303586
93positive regulation of ligase activity (GO:0051351)2.73754154
94establishment of protein localization to mitochondrion (GO:0072655)2.70454379
95signal transduction involved in DNA damage checkpoint (GO:0072422)2.70343864
96signal transduction involved in DNA integrity checkpoint (GO:0072401)2.70343864
97GTP biosynthetic process (GO:0006183)2.70005623
98base-excision repair, AP site formation (GO:0006285)2.69319023
99chromosome condensation (GO:0030261)2.65062624
100signal transduction involved in cell cycle checkpoint (GO:0072395)2.64718633

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.41767435
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.21715268
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12871504
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60203676
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49252024
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34068086
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.18717556
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.18343093
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05467691
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.03865246
11ZNF263_19887448_ChIP-Seq_K562_Human2.92124504
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91218622
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87223632
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76238564
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73841610
16DCP1A_22483619_ChIP-Seq_HELA_Human2.64913856
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60366876
18XRN2_22483619_ChIP-Seq_HELA_Human2.35861817
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26365494
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24370125
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14897685
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10296192
23E2F7_22180533_ChIP-Seq_HELA_Human2.09416121
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06549509
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04267423
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.02178810
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00330121
28ELK1_19687146_ChIP-ChIP_HELA_Human1.97683106
29TTF2_22483619_ChIP-Seq_HELA_Human1.95412370
30GABP_19822575_ChIP-Seq_HepG2_Human1.94272191
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92772869
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81949847
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.80374291
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.70541467
35VDR_23849224_ChIP-Seq_CD4+_Human1.67896548
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57469915
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57104502
38FOXP3_21729870_ChIP-Seq_TREG_Human1.56418188
39HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56294555
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.55879741
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54373218
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52883294
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52622567
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47746036
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.45190847
46KDM5A_27292631_Chip-Seq_BREAST_Human1.43023086
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42533387
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39458064
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37968114
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31302073
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27661705
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.26958273
53ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25931143
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25439594
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.24296618
56AR_21909140_ChIP-Seq_LNCAP_Human1.23093546
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23007694
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21857168
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20735507
60ATF3_27146783_Chip-Seq_COLON_Human1.19911925
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.18365583
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16162351
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12299480
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10900022
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09577161
66PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09233555
67ELF5_23300383_ChIP-Seq_T47D_Human1.08749826
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04645417
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.03531006
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01566979
71GATA6_25053715_ChIP-Seq_YYC3_Human1.01545230
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99949416
73STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99902728
74NANOG_16153702_ChIP-ChIP_HESCs_Human0.99093214
75EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97450772
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97316490
77GATA1_26923725_Chip-Seq_HPCs_Mouse0.97159450
78TET1_21451524_ChIP-Seq_MESCs_Mouse0.96292431
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96260797
80FOXP1_21924763_ChIP-Seq_HESCs_Human0.95931820
81GATA3_24758297_ChIP-Seq_MCF-7_Human0.95237841
82GATA4_25053715_ChIP-Seq_YYC3_Human0.94960517
83ERG_20517297_ChIP-Seq_VCAP_Human0.90810968
84MYC_18940864_ChIP-ChIP_HL60_Human0.90199266
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90070226
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89792967
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89558376
88KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87763580
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86710145
90ERA_21632823_ChIP-Seq_H3396_Human0.85615648
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.84339224
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83611952
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83155860
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82284055
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81018504
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79718307
97CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79304385
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78905593
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76103655
100CDX2_20551321_ChIP-Seq_CACO-2_Human0.75802892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.79627874
2MP0003806_abnormal_nucleotide_metabolis4.45886182
3MP0005410_abnormal_fertilization3.24787765
4MP0005377_hearing/vestibular/ear_phenot3.17410466
5MP0003878_abnormal_ear_physiology3.17410466
6MP0004957_abnormal_blastocyst_morpholog3.16536539
7MP0003693_abnormal_embryo_hatching3.16286110
8MP0008995_early_reproductive_senescence2.57984052
9MP0002254_reproductive_system_inflammat2.45588058
10MP0000516_abnormal_urinary_system2.38220547
11MP0005367_renal/urinary_system_phenotyp2.38220547
12MP0000566_synostosis2.22509974
13MP0000537_abnormal_urethra_morphology2.17266547
14MP0002796_impaired_skin_barrier2.09444461
15MP0005670_abnormal_white_adipose2.09069634
16MP0010234_abnormal_vibrissa_follicle2.08925118
17MP0008877_abnormal_DNA_methylation1.95918547
18MP0003077_abnormal_cell_cycle1.85017645
19MP0008058_abnormal_DNA_repair1.83845588
20MP0003718_maternal_effect1.81143014
21MP0003786_premature_aging1.73517660
22MP0004019_abnormal_vitamin_homeostasis1.70833144
23MP0006036_abnormal_mitochondrial_physio1.65079306
24MP0004264_abnormal_extraembryonic_tissu1.62614480
25MP0005501_abnormal_skin_physiology1.60514003
26MP0003111_abnormal_nucleus_morphology1.51589760
27MP0001929_abnormal_gametogenesis1.49862769
28MP0003186_abnormal_redox_activity1.49762125
29MP0003011_delayed_dark_adaptation1.46685672
30MP0002098_abnormal_vibrissa_morphology1.46530010
31MP0008875_abnormal_xenobiotic_pharmacok1.44768919
32MP0010678_abnormal_skin_adnexa1.43215995
33MP0000358_abnormal_cell_content/1.41930161
34MP0010094_abnormal_chromosome_stability1.41084912
35MP0002837_dystrophic_cardiac_calcinosis1.39471792
36MP0001756_abnormal_urination1.38662008
37MP0000383_abnormal_hair_follicle1.37997559
38MP0005408_hypopigmentation1.35773261
39MP0006035_abnormal_mitochondrial_morpho1.34577601
40MP0001727_abnormal_embryo_implantation1.34254171
41MP0001697_abnormal_embryo_size1.30990777
42MP0000372_irregular_coat_pigmentation1.27453517
43MP0001666_abnormal_nutrient_absorption1.26042012
44MP0003698_abnormal_male_reproductive1.25130713
45MP0008932_abnormal_embryonic_tissue1.23512528
46MP0008872_abnormal_physiological_respon1.22523876
47MP0003638_abnormal_response/metabolism_1.20711712
48MP0002210_abnormal_sex_determination1.19893646
49MP0001346_abnormal_lacrimal_gland1.19104940
50MP0002139_abnormal_hepatobiliary_system1.18613990
51MP0005084_abnormal_gallbladder_morpholo1.18156865
52MP0000647_abnormal_sebaceous_gland1.17528883
53MP0001293_anophthalmia1.17259800
54MP0005360_urolithiasis1.12472917
55MP0006054_spinal_hemorrhage1.11411500
56MP0005332_abnormal_amino_acid1.10338852
57MP0010030_abnormal_orbit_morphology1.09699292
58MP0003315_abnormal_perineum_morphology1.04295345
59MP0009643_abnormal_urine_homeostasis1.02367216
60MP0000350_abnormal_cell_proliferation1.02022632
61MP0001881_abnormal_mammary_gland1.01764167
62MP0002234_abnormal_pharynx_morphology1.00989230
63MP0000427_abnormal_hair_cycle0.99474262
64MP0000627_abnormal_mammary_gland0.99426247
65MP0003936_abnormal_reproductive_system0.98427565
66MP0002085_abnormal_embryonic_tissue0.95860521
67MP0001968_abnormal_touch/_nociception0.95213542
68MP0001145_abnormal_male_reproductive0.94250930
69MP0005380_embryogenesis_phenotype0.93826273
70MP0001672_abnormal_embryogenesis/_devel0.93826273
71MP0004147_increased_porphyrin_level0.92593496
72MP0002088_abnormal_embryonic_growth/wei0.89632103
73MP0003984_embryonic_growth_retardation0.88285555
74MP0001730_embryonic_growth_arrest0.85815115
75MP0005636_abnormal_mineral_homeostasis0.85725982
76MP0004782_abnormal_surfactant_physiolog0.84936296
77MP0010771_integument_phenotype0.84157048
78MP0000653_abnormal_sex_gland0.83946893
79MP0000049_abnormal_middle_ear0.83389150
80MP0002161_abnormal_fertility/fecundity0.82899433
81MP0002080_prenatal_lethality0.81921955
82MP0004233_abnormal_muscle_weight0.81002335
83MP0003252_abnormal_bile_duct0.80903219
84MP0002177_abnormal_outer_ear0.80635260
85MP0000467_abnormal_esophagus_morphology0.79936909
86MP0003937_abnormal_limbs/digits/tail_de0.77003009
87MP0003941_abnormal_skin_development0.75160082
88MP0001188_hyperpigmentation0.73669504
89MP0000762_abnormal_tongue_morphology0.72987785
90MP0003123_paternal_imprinting0.71781582
91MP0000313_abnormal_cell_death0.70739796
92MP0001485_abnormal_pinna_reflex0.68466980
93MP0002136_abnormal_kidney_physiology0.67583605
94MP0001286_abnormal_eye_development0.66884117
95MP0008007_abnormal_cellular_replicative0.66415914
96MP0002111_abnormal_tail_morphology0.65878004
97MP0003943_abnormal_hepatobiliary_system0.65157364
98MP0005075_abnormal_melanosome_morpholog0.64977555
99MP0002160_abnormal_reproductive_system0.64611488
100MP0002938_white_spotting0.63623942

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.87206590
2Mitochondrial inheritance (HP:0001427)4.68777761
3Abnormal mitochondria in muscle tissue (HP:0008316)4.67648675
4Acute encephalopathy (HP:0006846)4.53823091
5Hepatocellular necrosis (HP:0001404)4.33991255
6Hepatic necrosis (HP:0002605)4.19458721
7Micronodular cirrhosis (HP:0001413)4.19316757
8Increased CSF lactate (HP:0002490)4.12245567
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.88719294
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.88719294
11Progressive macrocephaly (HP:0004481)3.84927963
12Stenosis of the external auditory canal (HP:0000402)3.79723152
13Reticulocytopenia (HP:0001896)3.46224583
14Abnormality of cells of the erythroid lineage (HP:0012130)3.42100043
15Macrocytic anemia (HP:0001972)3.15951426
16Cerebral edema (HP:0002181)3.15475908
17Glycosuria (HP:0003076)3.05537680
18Abnormality of urine glucose concentration (HP:0011016)3.05537680
19Male infertility (HP:0003251)3.04157372
20Generalized aminoaciduria (HP:0002909)3.01536421
21Renal Fanconi syndrome (HP:0001994)2.94757908
22Lactic acidosis (HP:0003128)2.87888174
23Abnormal number of erythroid precursors (HP:0012131)2.86225128
24Abnormality of magnesium homeostasis (HP:0004921)2.84823433
25Increased hepatocellular lipid droplets (HP:0006565)2.80968754
26Proximal tubulopathy (HP:0000114)2.74305717
27Cone-rod dystrophy (HP:0000548)2.67890838
28Lipid accumulation in hepatocytes (HP:0006561)2.67440739
29Optic disc pallor (HP:0000543)2.62931313
30Increased serum lactate (HP:0002151)2.62808639
31Tetany (HP:0001281)2.62792424
32Severe visual impairment (HP:0001141)2.59405184
33Amelogenesis imperfecta (HP:0000705)2.57839110
34Respiratory failure (HP:0002878)2.54574795
35Abnormality of macular pigmentation (HP:0008002)2.51257915
36Renal tubular acidosis (HP:0001947)2.49029013
37Increased intramyocellular lipid droplets (HP:0012240)2.48896261
38Renal tubular dysfunction (HP:0000124)2.47546952
39Leukodystrophy (HP:0002415)2.39677927
40Congenital, generalized hypertrichosis (HP:0004540)2.38135510
41Exercise intolerance (HP:0003546)2.37647591
42Abnormality of the anterior horn cell (HP:0006802)2.37221786
43Degeneration of anterior horn cells (HP:0002398)2.37221786
44Bilateral sensorineural hearing impairment (HP:0008619)2.36256472
45Paralysis (HP:0003470)2.34511181
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28887460
47Type I transferrin isoform profile (HP:0003642)2.28545870
48Lethargy (HP:0001254)2.28242559
49Hyperglycinemia (HP:0002154)2.24115240
50Hypomagnesemia (HP:0002917)2.23168455
51Increased circulating renin level (HP:0000848)2.22826456
52Facial cleft (HP:0002006)2.22248802
53Nausea (HP:0002018)2.19798452
54Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19647059
55Sensory axonal neuropathy (HP:0003390)2.19164463
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19044121
57Concave nail (HP:0001598)2.16335857
58Increased muscle lipid content (HP:0009058)2.10700795
59Abnormality of renal resorption (HP:0011038)2.08854717
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05337493
61Decreased electroretinogram (ERG) amplitude (HP:0000654)2.03290876
62Sclerocornea (HP:0000647)2.00943444
63Polydipsia (HP:0001959)2.00818624
64Abnormal drinking behavior (HP:0030082)2.00818624
65Ureteral duplication (HP:0000073)1.98545364
66Scotoma (HP:0000575)1.98344704
67Subcapsular cataract (HP:0000523)1.95774741
68CNS demyelination (HP:0007305)1.95065749
69Abnormality of dental color (HP:0011073)1.94029500
70Congenital malformation of the right heart (HP:0011723)1.93806421
71Double outlet right ventricle (HP:0001719)1.93806421
72Woolly hair (HP:0002224)1.93196811
73Abnormality of the umbilical cord (HP:0010881)1.92007594
74Humeroradial synostosis (HP:0003041)1.91817012
75Synostosis involving the elbow (HP:0003938)1.91817012
76Cerebral palsy (HP:0100021)1.90763022
77Exertional dyspnea (HP:0002875)1.88207187
78Aplasia cutis congenita (HP:0001057)1.87671670
79Amniotic constriction ring (HP:0009775)1.87038122
80Abnormality of placental membranes (HP:0011409)1.87038122
81Palpitations (HP:0001962)1.86737735
82Patent foramen ovale (HP:0001655)1.84126936
83Abnormal protein glycosylation (HP:0012346)1.83213921
84Abnormal glycosylation (HP:0012345)1.83213921
85Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83213921
86Abnormal protein N-linked glycosylation (HP:0012347)1.83213921
87Birth length less than 3rd percentile (HP:0003561)1.81931282
88Abnormal auditory evoked potentials (HP:0006958)1.79617188
89Abnormal umbilical cord blood vessels (HP:0011403)1.77858111
90Single umbilical artery (HP:0001195)1.77858111
91Abnormality of the fetal cardiovascular system (HP:0010948)1.77858111
92Upper limb muscle weakness (HP:0003484)1.76449343
93Megaloblastic anemia (HP:0001889)1.75353309
94Septate vagina (HP:0001153)1.73048429
95High anterior hairline (HP:0009890)1.71947348
96Congenital ichthyosiform erythroderma (HP:0007431)1.70887798
97Hypoparathyroidism (HP:0000829)1.70740666
98Seborrheic dermatitis (HP:0001051)1.70596326
99Blindness (HP:0000618)1.70417487
100Vomiting (HP:0002013)1.69974621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.17314867
2EPHA23.75549727
3PLK43.46402323
4STK393.39679354
5ARAF3.38042680
6VRK23.27992898
7PBK3.20588975
8MAP3K93.04048589
9WNK42.93726793
10OXSR12.89619572
11NME22.62365017
12MST42.46416918
13MYLK2.07817689
14MAP3K131.99066022
15BUB11.97667288
16MST1R1.89262278
17ILK1.76345661
18PDK21.70322550
19BCKDK1.67008840
20NEK11.65569867
21RPS6KB21.65266164
22CDK191.57229298
23PAK41.49580245
24STK161.45815332
25TESK11.43072553
26SRPK11.36092122
27EIF2AK11.34597232
28CHEK21.28773396
29BRAF1.23780115
30EIF2AK31.22037008
31CDC71.17696637
32ABL21.16629303
33BMPR1B1.16424334
34DAPK11.04844050
35EPHB20.98940124
36INSRR0.97268065
37LATS20.94161269
38NME10.91762842
39PLK20.91379655
40CSNK1G30.90631698
41TRIM280.90572953
42VRK10.89572762
43DAPK30.88047883
44TESK20.87937209
45PIM20.80927449
46PLK10.80594179
47PNCK0.79191608
48CDK80.78761185
49CDK70.77391490
50SCYL20.74659024
51NEK20.74613923
52AURKB0.73938192
53CSNK1A1L0.73393042
54MAP3K80.73158507
55PASK0.73086261
56AURKA0.71317675
57STK38L0.69583031
58CSNK1G10.68214491
59CAMK2G0.68133204
60CSNK1G20.66097532
61NUAK10.65492541
62LIMK10.65441050
63LMTK20.60933615
64DYRK20.60696695
65PHKG10.59907615
66PHKG20.59907615
67MET0.58793398
68PRKCI0.51621151
69PINK10.50232152
70TNIK0.49623273
71DYRK30.48611859
72WNK30.46997496
73ERBB40.46943913
74PLK30.43106292
75PIK3CA0.41454801
76NEK60.40293386
77AKT20.40111268
78CSNK2A20.39882960
79GRK10.39666734
80CDK30.38931046
81CSNK2A10.38123332
82ZAK0.37803638
83DMPK0.37238481
84KDR0.37231842
85CHEK10.36650650
86PRKG20.36612081
87CAMK2D0.36201342
88MOS0.35244768
89TSSK60.34816289
90CSNK1E0.33709677
91TAF10.33427656
92ROCK10.32180470
93PAK10.32051809
94FGFR20.32032225
95IRAK30.31571830
96TLK10.29753910
97CSNK1A10.29674421
98MAP2K70.28500389
99RPS6KA40.28325563
100RAF10.28124721

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.00897117
2Oxidative phosphorylation_Homo sapiens_hsa001904.49000741
3Proteasome_Homo sapiens_hsa030504.28419386
4Parkinsons disease_Homo sapiens_hsa050123.43878413
5Huntingtons disease_Homo sapiens_hsa050162.80317940
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.79479919
7Collecting duct acid secretion_Homo sapiens_hsa049662.62787250
8Alzheimers disease_Homo sapiens_hsa050102.40314806
9RNA polymerase_Homo sapiens_hsa030202.17279994
10DNA replication_Homo sapiens_hsa030302.12107356
11Homologous recombination_Homo sapiens_hsa034402.11869483
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.10933452
13Folate biosynthesis_Homo sapiens_hsa007902.09749094
14RNA transport_Homo sapiens_hsa030131.94617027
15Vibrio cholerae infection_Homo sapiens_hsa051101.84131578
16Spliceosome_Homo sapiens_hsa030401.77940210
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77199244
18Base excision repair_Homo sapiens_hsa034101.76171999
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75720511
20Cardiac muscle contraction_Homo sapiens_hsa042601.74433137
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58684050
22Mismatch repair_Homo sapiens_hsa034301.55564908
23Fatty acid elongation_Homo sapiens_hsa000621.52597364
24Pyrimidine metabolism_Homo sapiens_hsa002401.47751509
25Basal transcription factors_Homo sapiens_hsa030221.39153783
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30610307
27RNA degradation_Homo sapiens_hsa030181.23966548
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.20178808
29Sulfur metabolism_Homo sapiens_hsa009201.20034307
30Sulfur relay system_Homo sapiens_hsa041221.18321807
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.06929017
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05108597
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03522218
34Pyruvate metabolism_Homo sapiens_hsa006201.02292882
35Fat digestion and absorption_Homo sapiens_hsa049751.02158586
36Protein export_Homo sapiens_hsa030600.99689907
37Nucleotide excision repair_Homo sapiens_hsa034200.93418870
38Purine metabolism_Homo sapiens_hsa002300.92715351
39Biosynthesis of amino acids_Homo sapiens_hsa012300.91800213
40Synaptic vesicle cycle_Homo sapiens_hsa047210.91533916
41One carbon pool by folate_Homo sapiens_hsa006700.91247468
42Phenylalanine metabolism_Homo sapiens_hsa003600.89414100
43Metabolic pathways_Homo sapiens_hsa011000.88182701
44Propanoate metabolism_Homo sapiens_hsa006400.87698299
45Carbon metabolism_Homo sapiens_hsa012000.87462019
46Selenocompound metabolism_Homo sapiens_hsa004500.85585503
47Glutathione metabolism_Homo sapiens_hsa004800.85023342
48Galactose metabolism_Homo sapiens_hsa000520.83556307
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.83396404
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83141322
51Fanconi anemia pathway_Homo sapiens_hsa034600.83139579
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79404834
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76010235
54mRNA surveillance pathway_Homo sapiens_hsa030150.74417250
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.73284210
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72990703
57Pancreatic secretion_Homo sapiens_hsa049720.72024572
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70730694
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70380240
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68887340
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67058348
62Vitamin digestion and absorption_Homo sapiens_hsa049770.64380845
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62861140
64Tyrosine metabolism_Homo sapiens_hsa003500.59768804
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57614424
66p53 signaling pathway_Homo sapiens_hsa041150.57395475
67Arginine and proline metabolism_Homo sapiens_hsa003300.55624842
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54395764
69Tight junction_Homo sapiens_hsa045300.54111756
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52273234
71Bladder cancer_Homo sapiens_hsa052190.52097012
72Fatty acid degradation_Homo sapiens_hsa000710.51283465
73Butanoate metabolism_Homo sapiens_hsa006500.51001917
74Arginine biosynthesis_Homo sapiens_hsa002200.48545510
75Cell cycle_Homo sapiens_hsa041100.47615588
76Chemical carcinogenesis_Homo sapiens_hsa052040.46986832
77Protein digestion and absorption_Homo sapiens_hsa049740.45844255
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.42330468
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42170496
80Fatty acid metabolism_Homo sapiens_hsa012120.41450604
81Arachidonic acid metabolism_Homo sapiens_hsa005900.39377116
82Bile secretion_Homo sapiens_hsa049760.36965082
83Tryptophan metabolism_Homo sapiens_hsa003800.36837878
84Starch and sucrose metabolism_Homo sapiens_hsa005000.36312347
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.36271329
86N-Glycan biosynthesis_Homo sapiens_hsa005100.35525438
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.35288399
88Hippo signaling pathway_Homo sapiens_hsa043900.35121702
89Peroxisome_Homo sapiens_hsa041460.32764727
90Retinol metabolism_Homo sapiens_hsa008300.32694528
91Thyroid cancer_Homo sapiens_hsa052160.32037612
92Ether lipid metabolism_Homo sapiens_hsa005650.29448026
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27168397
94Sphingolipid metabolism_Homo sapiens_hsa006000.27120810
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25935284
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.25919833
97Viral myocarditis_Homo sapiens_hsa054160.25778659
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25558461
99Non-homologous end-joining_Homo sapiens_hsa034500.25264848
100Steroid biosynthesis_Homo sapiens_hsa001000.24028537

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