ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	6.03103235
2	ATP synthesis coupled proton transport (GO:0015986)	5.15295269
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.15295269
4	proteasome assembly (GO:0043248)	5.08030044
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.04168236
6	oxygen transport (GO:0015671)	4.62608153
7	respiratory chain complex IV assembly (GO:0008535)	4.48860897
8	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.16037740
9	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.16037740
10	cytochrome complex assembly (GO:0017004)	4.08711032
11	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.97977220
12	gas transport (GO:0015669)	3.94752097
13	regulation of mitochondrial translation (GO:0070129)	3.94707669
14	homocysteine metabolic process (GO:0050667)	3.90932916
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.88301816
16	adult feeding behavior (GO:0008343)	3.80828187
17	protein autoprocessing (GO:0016540)	3.79347629
18	hydrogen ion transmembrane transport (GO:1902600)	3.78288052
19	electron transport chain (GO:0022900)	3.69981965
20	chromatin remodeling at centromere (GO:0031055)	3.68551150
21	regulation of oxidative phosphorylation (GO:0002082)	3.67770770
22	CENP-A containing nucleosome assembly (GO:0034080)	3.66670242
23	respiratory electron transport chain (GO:0022904)	3.66657202
24	rRNA modification (GO:0000154)	3.65814942
25	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.63208182
26	resolution of meiotic recombination intermediates (GO:0000712)	3.61678728
27	synapsis (GO:0007129)	3.59920252
28	kinetochore assembly (GO:0051382)	3.49998966
29	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.45590333
30	glycerophospholipid catabolic process (GO:0046475)	3.42828147
31	ribosomal small subunit assembly (GO:0000028)	3.38500759
32	protein complex biogenesis (GO:0070271)	3.36420229
33	histone exchange (GO:0043486)	3.33858271
34	proton transport (GO:0015992)	3.33591673
35	rRNA methylation (GO:0031167)	3.31943698
36	hydrogen transport (GO:0006818)	3.27548470
37	protein targeting to mitochondrion (GO:0006626)	3.25111617
38	S-adenosylmethionine metabolic process (GO:0046500)	3.23376437
39	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23109552
40	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.22109646
41	ATP hydrolysis coupled proton transport (GO:0015991)	3.22109646
42	ATP biosynthetic process (GO:0006754)	3.19170674
43	establishment of protein localization to mitochondrion (GO:0072655)	3.18702254
44	male meiosis I (GO:0007141)	3.17411143
45	kinetochore organization (GO:0051383)	3.16182206
46	response to redox state (GO:0051775)	3.13659961
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.12768770
48	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.11223737
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.11223737
50	NADH dehydrogenase complex assembly (GO:0010257)	3.11223737
51	ribosomal large subunit biogenesis (GO:0042273)	3.05128419
52	protein localization to mitochondrion (GO:0070585)	3.05024878
53	translation (GO:0006412)	3.00541278
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.99493486
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.97124181
56	mannosylation (GO:0097502)	2.87828922
57	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.87301414
58	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.87301414
59	water-soluble vitamin biosynthetic process (GO:0042364)	2.87184331
60	mitochondrial RNA metabolic process (GO:0000959)	2.86928145
61	signal peptide processing (GO:0006465)	2.86009964
62	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.83440302
63	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.82028339
64	tetrahydrofolate metabolic process (GO:0046653)	2.81424276
65	DNA replication checkpoint (GO:0000076)	2.80171063
66	cellular component biogenesis (GO:0044085)	2.75681728
67	pseudouridine synthesis (GO:0001522)	2.74694438
68	microtubule severing (GO:0051013)	2.74592064
69	nucleotide transmembrane transport (GO:1901679)	2.73987472
70	telomere maintenance via semi-conservative replication (GO:0032201)	2.72345206
71	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.70722862
72	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.69974800
73	pteridine-containing compound biosynthetic process (GO:0042559)	2.69888550
74	protein neddylation (GO:0045116)	2.69180481
75	nucleoside triphosphate biosynthetic process (GO:0009142)	2.68124585
76	double-strand break repair via nonhomologous end joining (GO:0006303)	2.68055020
77	non-recombinational repair (GO:0000726)	2.68055020
78	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.66347940
79	DNA double-strand break processing (GO:0000729)	2.66024700
80	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.65633169
81	ribosomal small subunit biogenesis (GO:0042274)	2.65516992
82	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.65297514
83	DNA damage response, detection of DNA damage (GO:0042769)	2.64948506
84	DNA deamination (GO:0045006)	2.64021389
85	rRNA processing (GO:0006364)	2.63618668
86	meiosis I (GO:0007127)	2.63167378
87	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.62934228
88	aldehyde catabolic process (GO:0046185)	2.62644610
89	sperm motility (GO:0030317)	2.62060644
90	rRNA metabolic process (GO:0016072)	2.60561853
91	single strand break repair (GO:0000012)	2.60322109
92	viral transcription (GO:0019083)	2.58860991
93	protein targeting to ER (GO:0045047)	2.58764409
94	cotranslational protein targeting to membrane (GO:0006613)	2.58199374
95	tRNA processing (GO:0008033)	2.56353011
96	translational termination (GO:0006415)	2.56340907
97	ribonucleoprotein complex biogenesis (GO:0022613)	2.55792610
98	protein localization to kinetochore (GO:0034501)	2.55726442
99	detection of calcium ion (GO:0005513)	2.55630551
100	artery smooth muscle contraction (GO:0014824)	2.54750869

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.68173634
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.21090915
3	E2F7_22180533_ChIP-Seq_HELA_Human	3.64906771
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.52923736
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.06274757
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96101926
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.86928026
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.66563594
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.61129648
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.46169894
11	VDR_22108803_ChIP-Seq_LS180_Human	2.45449168
12	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.40078190
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.35717676
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.33829214
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.27447674
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.19562595
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11919027
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.08469370
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.04218282
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99338889
21	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.98558274
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.96441621
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92516127
24	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.90723245
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.89169697
26	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.85559354
27	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.80191238
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.79375199
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.74759973
30	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.74210035
31	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.71638560
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.71342368
33	TTF2_22483619_ChIP-Seq_HELA_Human	1.70817850
34	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.70416233
35	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.67383255
36	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.67168510
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.65921594
38	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.65250954
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.62592886
40	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.61433630
41	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.60172585
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59279145
43	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.54932202
44	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.52944358
45	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.43725184
46	KDM5A_27292631_Chip-Seq_BREAST_Human	1.43445394
47	ZNF263_19887448_ChIP-Seq_K562_Human	1.41237349
48	IRF1_19129219_ChIP-ChIP_H3396_Human	1.39775191
49	AR_21909140_ChIP-Seq_LNCAP_Human	1.37347675
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.33816253
51	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.32969884
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.31669744
53	RBPJ_21746931_ChIP-Seq_IB4_Human	1.28900434
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27366536
55	EWS_26573619_Chip-Seq_HEK293_Human	1.27337423
56	PHF8_20622853_ChIP-Seq_HELA_Human	1.26271313
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.25331482
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.25277808
59	XRN2_22483619_ChIP-Seq_HELA_Human	1.24449748
60	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.20981005
61	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.19739133
62	FUS_26573619_Chip-Seq_HEK293_Human	1.17726894
63	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.16887373
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.15317819
65	NCOR_22424771_ChIP-Seq_293T_Human	1.14266546
66	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13663952
67	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.13003337
68	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.11797180
69	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.11531836
70	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.11280729
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10664158
72	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10124604
73	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.08405579
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06887021
75	P300_19829295_ChIP-Seq_ESCs_Human	1.05341034
76	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.05262197
77	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.04458050
78	NFYB_21822215_ChIP-Seq_K562_Human	1.03844306
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.01965758
80	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.01381750
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.01253146
82	AR_20517297_ChIP-Seq_VCAP_Human	1.00824141
83	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.98610095
84	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96643962
85	HOXB7_26014856_ChIP-Seq_BT474_Human	0.96538807
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95416261
87	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95145859
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94465836
89	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94148146
90	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94148146
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.94111995
92	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93927035
93	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.93864650
94	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92855331
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.90859471
96	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.88441876
97	NFYA_21822215_ChIP-Seq_K562_Human	0.87980604
98	ER_23166858_ChIP-Seq_MCF-7_Human	0.86486521
99	SOX2_19829295_ChIP-Seq_ESCs_Human	0.86469727
100	NANOG_19829295_ChIP-Seq_ESCs_Human	0.86469727

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	4.28934050
2	MP0005377_hearing/vestibular/ear_phenot	4.28934050
3	MP0006292_abnormal_olfactory_placode	3.78980884
4	MP0002102_abnormal_ear_morphology	3.51878952
5	MP0004147_increased_porphyrin_level	3.25667478
6	MP0008877_abnormal_DNA_methylation	2.97037559
7	MP0008058_abnormal_DNA_repair	2.56397492
8	MP0005670_abnormal_white_adipose	2.54096542
9	MP0002254_reproductive_system_inflammat	2.37993209
10	MP0005379_endocrine/exocrine_gland_phen	2.34269400
11	MP0000015_abnormal_ear_pigmentation	2.27061951
12	MP0006035_abnormal_mitochondrial_morpho	2.12993816
13	MP0003718_maternal_effect	2.11953873
14	MP0005645_abnormal_hypothalamus_physiol	2.09311178
15	MP0003787_abnormal_imprinting	2.07896977
16	MP0003806_abnormal_nucleotide_metabolis	2.06654288
17	MP0003186_abnormal_redox_activity	2.02706041
18	MP0004019_abnormal_vitamin_homeostasis	1.96322390
19	MP0003646_muscle_fatigue	1.91969338
20	MP0001293_anophthalmia	1.90793645
21	MP0003693_abnormal_embryo_hatching	1.87328988
22	MP0006036_abnormal_mitochondrial_physio	1.81378188
23	MP0005636_abnormal_mineral_homeostasis	1.72043905
24	MP0005410_abnormal_fertilization	1.68367237
25	MP0002163_abnormal_gland_morphology	1.66690638
26	MP0005083_abnormal_biliary_tract	1.65916470
27	MP0004957_abnormal_blastocyst_morpholog	1.58928418
28	MP0002837_dystrophic_cardiac_calcinosis	1.58344125
29	MP0003122_maternal_imprinting	1.46125949
30	MP0000013_abnormal_adipose_tissue	1.45513104
31	MP0003123_paternal_imprinting	1.43118850
32	MP0005646_abnormal_pituitary_gland	1.41368709
33	MP0001542_abnormal_bone_strength	1.40654173
34	MP0002132_abnormal_respiratory_system	1.39715469
35	MP0003786_premature_aging	1.39159976
36	MP0004133_heterotaxia	1.37078303
37	MP0003195_calcinosis	1.37010727
38	MP0010094_abnormal_chromosome_stability	1.36544798
39	MP0002938_white_spotting	1.35323174
40	MP0008875_abnormal_xenobiotic_pharmacok	1.34195980
41	MP0008872_abnormal_physiological_respon	1.28601649
42	MP0003880_abnormal_central_pattern	1.28239261
43	MP0004142_abnormal_muscle_tone	1.28190463
44	MP0006276_abnormal_autonomic_nervous	1.28164170
45	MP0005332_abnormal_amino_acid	1.23345293
46	MP0002638_abnormal_pupillary_reflex	1.20827086
47	MP0001764_abnormal_homeostasis	1.18465268
48	MP0002210_abnormal_sex_determination	1.17868345
49	MP0001929_abnormal_gametogenesis	1.15899425
50	MP0003698_abnormal_male_reproductive	1.14725473
51	MP0003111_abnormal_nucleus_morphology	1.08731544
52	MP0003283_abnormal_digestive_organ	1.07228365
53	MP0008995_early_reproductive_senescence	1.06629792
54	MP0000647_abnormal_sebaceous_gland	1.06142239
55	MP0001968_abnormal_touch/_nociception	1.06079981
56	MP0002736_abnormal_nociception_after	1.05794038
57	MP0002095_abnormal_skin_pigmentation	1.02219786
58	MP0003136_yellow_coat_color	0.99096211
59	MP0003121_genomic_imprinting	0.98437027
60	MP0001919_abnormal_reproductive_system	0.96417359
61	MP0002177_abnormal_outer_ear	0.96117982
62	MP0000653_abnormal_sex_gland	0.94826921
63	MP0005084_abnormal_gallbladder_morpholo	0.94357671
64	MP0004215_abnormal_myocardial_fiber	0.93185967
65	MP0001145_abnormal_male_reproductive	0.92266129
66	MP0008932_abnormal_embryonic_tissue	0.90798446
67	MP0000358_abnormal_cell_content/	0.88374721
68	MP0000631_abnormal_neuroendocrine_gland	0.86907628
69	MP0004085_abnormal_heartbeat	0.86191791
70	MP0003938_abnormal_ear_development	0.84761776
71	MP0004885_abnormal_endolymph	0.83352262
72	MP0001529_abnormal_vocalization	0.82666165
73	MP0003567_abnormal_fetal_cardiomyocyte	0.81385203
74	MP0002277_abnormal_respiratory_mucosa	0.81375634
75	MP0002693_abnormal_pancreas_physiology	0.80825857
76	MP0005389_reproductive_system_phenotype	0.79423427
77	MP0003077_abnormal_cell_cycle	0.79091993
78	MP0000372_irregular_coat_pigmentation	0.78812141
79	MP0001765_abnormal_ion_homeostasis	0.77798291
80	MP0001756_abnormal_urination	0.76713043
81	MP0001286_abnormal_eye_development	0.75873579
82	MP0005448_abnormal_energy_balance	0.75409639
83	MP0000383_abnormal_hair_follicle	0.74084063
84	MP0010386_abnormal_urinary_bladder	0.72049243
85	MP0009046_muscle_twitch	0.71539986
86	MP0008789_abnormal_olfactory_epithelium	0.71335396
87	MP0000639_abnormal_adrenal_gland	0.70216692
88	MP0002909_abnormal_adrenal_gland	0.69703216
89	MP0002735_abnormal_chemical_nociception	0.68367133
90	MP0003953_abnormal_hormone_level	0.68284104
91	MP0002161_abnormal_fertility/fecundity	0.68039587
92	MP0004742_abnormal_vestibular_system	0.67658531
93	MP0009379_abnormal_foot_pigmentation	0.66424080
94	MP0004043_abnormal_pH_regulation	0.66125841
95	MP0005551_abnormal_eye_electrophysiolog	0.65589486
96	MP0003638_abnormal_response/metabolism_	0.64468546
97	MP0000538_abnormal_urinary_bladder	0.64345967
98	MP0001485_abnormal_pinna_reflex	0.63370005
99	MP0002653_abnormal_ependyma_morphology	0.62561039
100	MP0000427_abnormal_hair_cycle	0.62473215

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal hemoglobin (HP:0011902)	4.90202300
2	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.87773955
3	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.87773955
4	Acute necrotizing encephalopathy (HP:0006965)	4.70179053
5	Abnormality of the heme biosynthetic pathway (HP:0010472)	4.68554987
6	Acute encephalopathy (HP:0006846)	4.23594738
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.11512484
8	Progressive macrocephaly (HP:0004481)	4.01320884
9	Mitochondrial inheritance (HP:0001427)	3.82364685
10	Hepatocellular necrosis (HP:0001404)	3.59098262
11	Hypomagnesemia (HP:0002917)	3.47065912
12	Increased CSF lactate (HP:0002490)	3.44672196
13	Abnormality of magnesium homeostasis (HP:0004921)	3.35692705
14	Hepatic necrosis (HP:0002605)	3.29226907
15	Cerebral edema (HP:0002181)	3.22203739
16	Degeneration of anterior horn cells (HP:0002398)	3.15945630
17	Abnormality of the anterior horn cell (HP:0006802)	3.15945630
18	Methylmalonic acidemia (HP:0002912)	2.92480691
19	Renal Fanconi syndrome (HP:0001994)	2.87901465
20	Methylmalonic aciduria (HP:0012120)	2.86526374
21	Tetany (HP:0001281)	2.75686337
22	Pancreatic cysts (HP:0001737)	2.59923345
23	True hermaphroditism (HP:0010459)	2.59865016
24	Pallor (HP:0000980)	2.58946200
25	Increased circulating renin level (HP:0000848)	2.56721336
26	Increased hepatocellular lipid droplets (HP:0006565)	2.55557152
27	Pancreatic fibrosis (HP:0100732)	2.55396216
28	Lethargy (HP:0001254)	2.51978100
29	Molar tooth sign on MRI (HP:0002419)	2.51807635
30	Abnormality of midbrain morphology (HP:0002418)	2.51807635
31	Polydipsia (HP:0001959)	2.45556554
32	Abnormal drinking behavior (HP:0030082)	2.45556554
33	Optic disc pallor (HP:0000543)	2.44081959
34	Poor head control (HP:0002421)	2.41765526
35	Respiratory failure (HP:0002878)	2.40502586
36	Renal tubular dysfunction (HP:0000124)	2.38334576
37	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.36778435
38	Lactic acidosis (HP:0003128)	2.35014637
39	Lipid accumulation in hepatocytes (HP:0006561)	2.33751531
40	Abnormality of homocysteine metabolism (HP:0010919)	2.31483545
41	Homocystinuria (HP:0002156)	2.31483545
42	Leukodystrophy (HP:0002415)	2.31072234
43	Renal tubular acidosis (HP:0001947)	2.28936193
44	Abnormality of cells of the erythroid lineage (HP:0012130)	2.24958508
45	CNS demyelination (HP:0007305)	2.24037093
46	Abnormality of renal resorption (HP:0011038)	2.21790985
47	Proximal tubulopathy (HP:0000114)	2.20262482
48	Progressive inability to walk (HP:0002505)	2.19676985
49	Increased intramyocellular lipid droplets (HP:0012240)	2.14257934
50	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.13033471
51	Abnormality of alanine metabolism (HP:0010916)	2.12349688
52	Hyperalaninemia (HP:0003348)	2.12349688
53	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.12349688
54	Increased serum lactate (HP:0002151)	2.08238853
55	Tubulointerstitial nephritis (HP:0001970)	2.08011016
56	Albinism (HP:0001022)	2.06992261
57	Chronic hepatic failure (HP:0100626)	2.05449058
58	Abnormality of urine glucose concentration (HP:0011016)	2.05167405
59	Glycosuria (HP:0003076)	2.05167405
60	Exercise intolerance (HP:0003546)	2.02044948
61	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.99977621
62	Abnormality of the labia minora (HP:0012880)	1.98940316
63	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.98517247
64	Birth length less than 3rd percentile (HP:0003561)	1.98495445
65	Macrocytic anemia (HP:0001972)	1.96372386
66	Generalized aminoaciduria (HP:0002909)	1.95941317
67	Reticulocytopenia (HP:0001896)	1.95632491
68	Severe visual impairment (HP:0001141)	1.95115359
69	Abnormality of vitamin B metabolism (HP:0004340)	1.95057695
70	Hyperphosphaturia (HP:0003109)	1.94195582
71	Cerebral hypomyelination (HP:0006808)	1.93827288
72	Abnormal number of erythroid precursors (HP:0012131)	1.93473439
73	Exertional dyspnea (HP:0002875)	1.93337054
74	Nephronophthisis (HP:0000090)	1.91806572
75	Congenital stationary night blindness (HP:0007642)	1.91742539
76	Sclerocornea (HP:0000647)	1.89538907
77	Cystic liver disease (HP:0006706)	1.88015188
78	Azoospermia (HP:0000027)	1.85265172
79	Polyuria (HP:0000103)	1.84869355
80	Anencephaly (HP:0002323)	1.84497490
81	Optic nerve coloboma (HP:0000588)	1.84184550
82	Concave nail (HP:0001598)	1.83381618
83	Abnormality of macular pigmentation (HP:0008002)	1.83245087
84	Hypokinesia (HP:0002375)	1.83175104
85	Chromsome breakage (HP:0040012)	1.82168151
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.80150627
87	Insulin-resistant diabetes mellitus (HP:0000831)	1.78448452
88	Meckel diverticulum (HP:0002245)	1.78181549
89	Type I transferrin isoform profile (HP:0003642)	1.77774852
90	Anophthalmia (HP:0000528)	1.77320627
91	Abnormality of serum amino acid levels (HP:0003112)	1.75804611
92	Hypoplastic pelvis (HP:0008839)	1.75409989
93	Hyperphosphatemia (HP:0002905)	1.74773063
94	Abnormal hair laboratory examination (HP:0003328)	1.72197875
95	Increased muscle lipid content (HP:0009058)	1.71614954
96	Prominent metopic ridge (HP:0005487)	1.71446041
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71223358
98	Adrenal hypoplasia (HP:0000835)	1.70245501
99	Abnormality of glycolysis (HP:0004366)	1.69666620
100	Testicular atrophy (HP:0000029)	1.68809749

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK1	4.29244944
2	TRIM28	3.24822599
3	PDK2	3.13018685
4	MST4	2.92125797
5	WNK4	2.53968691
6	OXSR1	2.49310576
7	STK39	2.48961925
8	FRK	2.48278949
9	NEK1	2.26745276
10	CDC7	2.06947699
11	PINK1	2.00527164
12	EIF2AK3	1.90961758
13	ABL2	1.81717838
14	PLK4	1.78710893
15	GRK1	1.73851975
16	DYRK2	1.68683526
17	NME2	1.62852844
18	VRK2	1.62540140
19	RPS6KB2	1.50379409
20	BMPR1B	1.44151144
21	STK16	1.43719598
22	WNK3	1.40193457
23	NUAK1	1.39640425
24	MAP2K6	1.36071298
25	EPHA2	1.35157683
26	CAMK2D	1.31184940
27	ADRBK2	1.29822924
28	MKNK2	1.28984668
29	TNIK	1.27290842
30	MAP3K12	1.27121305
31	PBK	1.26501365
32	TSSK6	1.25022386
33	TTK	1.23478040
34	VRK1	1.22135442
35	PLK1	1.22039084
36	PLK3	1.20425026
37	ZAK	1.13621143
38	BUB1	1.11131638
39	MAP3K4	1.10926626
40	CHEK2	1.09112520
41	NME1	1.08249713
42	INSRR	1.05588599
43	MAP4K2	1.00330001
44	TRPM7	0.96895235
45	ILK	0.93772026
46	EPHA4	0.91291599
47	WEE1	0.90913929
48	PLK2	0.90691060
49	RPS6KA5	0.90160561
50	PRKCG	0.89379912
51	PKN1	0.85958210
52	MYLK	0.83790340
53	CSNK1G1	0.83346200
54	STK4	0.82613016
55	PRKCE	0.82168442
56	MKNK1	0.73641585
57	ADRBK1	0.72567561
58	DAPK3	0.72522656
59	PHKG1	0.71868554
60	PHKG2	0.71868554
61	DAPK1	0.70869446
62	LIMK1	0.68569469
63	BRSK1	0.67520508
64	CSNK1G3	0.67073263
65	CAMK2G	0.66784238
66	SIK3	0.66233227
67	EIF2AK2	0.64549301
68	STK3	0.63966232
69	CSNK2A1	0.63574176
70	CDK3	0.63366696
71	MAP3K8	0.62978901
72	MST1R	0.61308999
73	CAMK2A	0.61304884
74	CHEK1	0.59120003
75	YES1	0.59099397
76	PRKCI	0.58443469
77	CSNK2A2	0.57907726
78	FLT3	0.57507539
79	AKT2	0.55738756
80	PASK	0.54991513
81	BCKDK	0.54677005
82	AURKB	0.54165958
83	TESK1	0.53490768
84	CDK19	0.52818900
85	ATM	0.50703286
86	CDK7	0.49180204
87	DAPK2	0.46075101
88	CAMK2B	0.45883201
89	MINK1	0.43589155
90	STK38L	0.43310540
91	BRSK2	0.43257513
92	MAPK13	0.42994739
93	TIE1	0.42608841
94	CDK8	0.39808917
95	MELK	0.39646347
96	CASK	0.39262779
97	CSNK1A1L	0.39116595
98	KDR	0.36873998
99	CSNK1G2	0.36522541
100	CSNK1A1	0.36232167

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.97048327
2	Ribosome_Homo sapiens_hsa03010	3.27065004
3	Parkinsons disease_Homo sapiens_hsa05012	3.21552710
4	Proteasome_Homo sapiens_hsa03050	3.06322472
5	One carbon pool by folate_Homo sapiens_hsa00670	2.55153858
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.45487593
7	Protein export_Homo sapiens_hsa03060	2.45048519
8	Huntingtons disease_Homo sapiens_hsa05016	2.30382795
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.28712204
10	Mismatch repair_Homo sapiens_hsa03430	2.27214247
11	Basal transcription factors_Homo sapiens_hsa03022	2.10170875
12	DNA replication_Homo sapiens_hsa03030	2.07800029
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.05389900
14	Fanconi anemia pathway_Homo sapiens_hsa03460	1.98509946
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.96486922
16	RNA polymerase_Homo sapiens_hsa03020	1.88854990
17	Homologous recombination_Homo sapiens_hsa03440	1.86753490
18	Nucleotide excision repair_Homo sapiens_hsa03420	1.86030105
19	Alzheimers disease_Homo sapiens_hsa05010	1.84265528
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.78653018
21	RNA degradation_Homo sapiens_hsa03018	1.64467813
22	Base excision repair_Homo sapiens_hsa03410	1.63765243
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.58828163
24	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.57514114
25	Folate biosynthesis_Homo sapiens_hsa00790	1.56633138
26	Propanoate metabolism_Homo sapiens_hsa00640	1.56041838
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54681725
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.46023048
29	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.44492131
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43247099
31	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.41905286
32	RNA transport_Homo sapiens_hsa03013	1.41032328
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39611957
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.37128715
35	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31008439
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.29465017
37	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.29268561
38	Glutathione metabolism_Homo sapiens_hsa00480	1.15194946
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.14757575
40	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.10483638
41	Spliceosome_Homo sapiens_hsa03040	1.08705798
42	Vibrio cholerae infection_Homo sapiens_hsa05110	1.01704675
43	Metabolic pathways_Homo sapiens_hsa01100	1.00168243
44	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.99911755
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.95844552
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.93786773
47	Purine metabolism_Homo sapiens_hsa00230	0.91093356
48	Butanoate metabolism_Homo sapiens_hsa00650	0.86903622
49	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.86521494
50	Caffeine metabolism_Homo sapiens_hsa00232	0.86386582
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.85845361
52	Carbon metabolism_Homo sapiens_hsa01200	0.82165872
53	Sulfur metabolism_Homo sapiens_hsa00920	0.80358267
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.80089371
55	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.79061877
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.78365320
57	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.76744901
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.75657068
59	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.75483351
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.74776729
61	Sphingolipid metabolism_Homo sapiens_hsa00600	0.74096060
62	Arginine biosynthesis_Homo sapiens_hsa00220	0.73088360
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72881403
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72198418
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69928698
66	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69024264
67	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.66400194
68	Phototransduction_Homo sapiens_hsa04744	0.65542266
69	Peroxisome_Homo sapiens_hsa04146	0.64749117
70	Tryptophan metabolism_Homo sapiens_hsa00380	0.62525279
71	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.61591881
72	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61195108
73	Nitrogen metabolism_Homo sapiens_hsa00910	0.56913328
74	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54773920
75	Insulin secretion_Homo sapiens_hsa04911	0.52380901
76	Linoleic acid metabolism_Homo sapiens_hsa00591	0.51730355
77	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.50926926
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.50395702
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49243991
80	Retinol metabolism_Homo sapiens_hsa00830	0.48839070
81	mRNA surveillance pathway_Homo sapiens_hsa03015	0.48243649
82	Cell cycle_Homo sapiens_hsa04110	0.47136176
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46275069
84	Olfactory transduction_Homo sapiens_hsa04740	0.45075159
85	Tight junction_Homo sapiens_hsa04530	0.43492301
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.41666588
87	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.41004325
88	Nicotine addiction_Homo sapiens_hsa05033	0.40926141
89	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.40925336
90	Fatty acid degradation_Homo sapiens_hsa00071	0.39637816
91	Fat digestion and absorption_Homo sapiens_hsa04975	0.38426218
92	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37919427
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.36415438
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.32156247
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.28748878
96	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.28651611
97	Tyrosine metabolism_Homo sapiens_hsa00350	0.28422680
98	GABAergic synapse_Homo sapiens_hsa04727	0.28084399
99	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27948283
100	Morphine addiction_Homo sapiens_hsa05032	0.23117983

KRT18P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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