ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.28522206
2	proteasome assembly (GO:0043248)	5.69737679
3	regulation of mitochondrial translation (GO:0070129)	5.25003116
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.18407368
5	DNA deamination (GO:0045006)	4.85293467
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.72095699
7	ATP synthesis coupled proton transport (GO:0015986)	4.72095699
8	ribosomal small subunit assembly (GO:0000028)	4.67259010
9	regulation of cellular respiration (GO:0043457)	4.32699434
10	water-soluble vitamin biosynthetic process (GO:0042364)	4.32455462
11	pseudouridine synthesis (GO:0001522)	4.15911330
12	ribosomal small subunit biogenesis (GO:0042274)	4.09276217
13	daunorubicin metabolic process (GO:0044597)	4.00079133
14	polyketide metabolic process (GO:0030638)	4.00079133
15	doxorubicin metabolic process (GO:0044598)	4.00079133
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.85646824
17	viral transcription (GO:0019083)	3.84992952
18	protein targeting to ER (GO:0045047)	3.84711362
19	chaperone-mediated protein transport (GO:0072321)	3.83041402
20	regulation of oxidative phosphorylation (GO:0002082)	3.81260738
21	cotranslational protein targeting to membrane (GO:0006613)	3.77604556
22	translational termination (GO:0006415)	3.75977183
23	male meiosis I (GO:0007141)	3.75941826
24	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.73803239
25	protein neddylation (GO:0045116)	3.73338453
26	artery smooth muscle contraction (GO:0014824)	3.71617204
27	DNA replication checkpoint (GO:0000076)	3.69941993
28	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.68277757
29	cytochrome complex assembly (GO:0017004)	3.67600353
30	mitochondrial DNA replication (GO:0006264)	3.66536333
31	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.61652330
32	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.61652330
33	protein localization to endoplasmic reticulum (GO:0070972)	3.59489318
34	intracellular protein transmembrane import (GO:0044743)	3.58923197
35	aminoglycoside antibiotic metabolic process (GO:0030647)	3.54528616
36	translation (GO:0006412)	3.54003206
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.53164149
38	termination of RNA polymerase III transcription (GO:0006386)	3.53164149
39	synapsis (GO:0007129)	3.52227916
40	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.49427673
41	cytidine metabolic process (GO:0046087)	3.48716554
42	cytidine catabolic process (GO:0006216)	3.48716554
43	cytidine deamination (GO:0009972)	3.48716554
44	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.47826372
45	nucleotide transmembrane transport (GO:1901679)	3.47716558
46	xenobiotic catabolic process (GO:0042178)	3.47523539
47	electron transport chain (GO:0022900)	3.45029738
48	prostaglandin biosynthetic process (GO:0001516)	3.43781103
49	prostanoid biosynthetic process (GO:0046457)	3.43781103
50	ribosomal large subunit biogenesis (GO:0042273)	3.42840320
51	L-ascorbic acid metabolic process (GO:0019852)	3.42672309
52	respiratory electron transport chain (GO:0022904)	3.41890402
53	macrophage chemotaxis (GO:0048246)	3.41882462
54	translational elongation (GO:0006414)	3.35844099
55	meiosis I (GO:0007127)	3.33315451
56	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.32479211
57	iron-sulfur cluster assembly (GO:0016226)	3.32029644
58	metallo-sulfur cluster assembly (GO:0031163)	3.32029644
59	maturation of SSU-rRNA (GO:0030490)	3.30442608
60	maturation of 5.8S rRNA (GO:0000460)	3.26421856
61	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.25695083
62	tonic smooth muscle contraction (GO:0014820)	3.24119164
63	CENP-A containing nucleosome assembly (GO:0034080)	3.21728293
64	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.18001040
65	nucleoside transmembrane transport (GO:1901642)	3.16589789
66	chromatin remodeling at centromere (GO:0031055)	3.15424434
67	viral life cycle (GO:0019058)	3.15034254
68	amino acid salvage (GO:0043102)	3.13424634
69	L-methionine salvage (GO:0071267)	3.13424634
70	L-methionine biosynthetic process (GO:0071265)	3.13424634
71	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.13121462
72	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.09100864
73	translational initiation (GO:0006413)	3.08959230
74	respiratory chain complex IV assembly (GO:0008535)	3.08531153
75	protein complex biogenesis (GO:0070271)	3.07484337
76	histone mRNA metabolic process (GO:0008334)	3.07322813
77	protein peptidyl-prolyl isomerization (GO:0000413)	3.06594365
78	hepatocyte apoptotic process (GO:0097284)	3.05523530
79	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.04812816
80	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.04564222
81	cyclooxygenase pathway (GO:0019371)	3.03414751
82	prostanoid metabolic process (GO:0006692)	3.02342374
83	prostaglandin metabolic process (GO:0006693)	3.02342374
84	glucuronate metabolic process (GO:0019585)	3.01766742
85	uronic acid metabolic process (GO:0006063)	3.01766742
86	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.00912652
87	GTP biosynthetic process (GO:0006183)	2.99800459
88	ncRNA 3-end processing (GO:0043628)	2.98252786
89	ribonucleoprotein complex biogenesis (GO:0022613)	2.95389182
90	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94161734
91	ATP biosynthetic process (GO:0006754)	2.92381084
92	hydrogen ion transmembrane transport (GO:1902600)	2.88836441
93	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.86607189
94	protein targeting to mitochondrion (GO:0006626)	2.84325219
95	establishment of protein localization to mitochondrion (GO:0072655)	2.83939782
96	mitochondrial respiratory chain complex assembly (GO:0033108)	2.83834734
97	meiotic chromosome segregation (GO:0045132)	2.83079631
98	terpenoid biosynthetic process (GO:0016114)	2.82467727
99	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.82092272
100	regulation of cellular amino acid metabolic process (GO:0006521)	2.79848023

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.36033133
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.74976729
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.27628742
4	E2F7_22180533_ChIP-Seq_HELA_Human	3.84600282
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.71874131
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56526119
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.41165737
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.13806493
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.11798927
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.02053196
11	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.97961253
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.97758960
13	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.80410927
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.79131552
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53079975
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.44918757
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.35043782
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.19618075
19	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.17265915
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13965355
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.10904287
22	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.07668671
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.06261459
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.02819842
25	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.02074036
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.98787893
27	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.97296593
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.92756719
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.92188818
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.83194173
31	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80494465
32	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.74943694
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70988703
34	TTF2_22483619_ChIP-Seq_HELA_Human	1.69827922
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65392525
36	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.64923666
37	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.59476889
38	XRN2_22483619_ChIP-Seq_HELA_Human	1.59452743
39	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.56305084
40	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.50837142
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50785705
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.50625250
43	AR_21909140_ChIP-Seq_LNCAP_Human	1.50253497
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.48805769
45	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45621937
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43169141
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.40821864
48	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.38087449
49	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.37597691
50	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.33411439
51	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.33275404
52	GATA4_25053715_ChIP-Seq_YYC3_Human	1.31742769
53	KDM5A_27292631_Chip-Seq_BREAST_Human	1.29489640
54	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.26519146
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.23606995
56	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.20197907
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.11427881
58	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.11328658
59	ELF5_23300383_ChIP-Seq_T47D_Human	1.11241195
60	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.11234755
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10431777
62	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.09983898
63	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.09683930
64	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.06385243
65	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.06359862
66	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.02526474
67	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02266635
68	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.98474631
69	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.96287310
70	CIITA_25753668_ChIP-Seq_RAJI_Human	0.96017379
71	ERG_20517297_ChIP-Seq_VCAP_Human	0.95888237
72	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.95726893
73	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.93396289
74	TP53_22573176_ChIP-Seq_HFKS_Human	0.89679593
75	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.88443718
76	AR_20517297_ChIP-Seq_VCAP_Human	0.87007529
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.86770843
78	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.86611081
79	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.86519221
80	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.86519221
81	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.86324023
82	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.86075974
83	HOXB7_26014856_ChIP-Seq_BT474_Human	0.85873654
84	EWS_26573619_Chip-Seq_HEK293_Human	0.85812458
85	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.85261835
86	ZNF274_21170338_ChIP-Seq_K562_Hela	0.84733651
87	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.83761720
88	HTT_18923047_ChIP-ChIP_STHdh_Human	0.83362903
89	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.82963148
90	ERA_21632823_ChIP-Seq_H3396_Human	0.81461263
91	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.81034269
92	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.79289241
93	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.78748442
94	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	0.77060384
95	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.76946433
96	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.76814691
97	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.76461968
98	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.75529671
99	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.75402745
100	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.75343901

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.87982618
2	MP0003878_abnormal_ear_physiology	4.15144198
3	MP0005377_hearing/vestibular/ear_phenot	4.15144198
4	MP0003806_abnormal_nucleotide_metabolis	3.93028027
5	MP0003693_abnormal_embryo_hatching	3.59151365
6	MP0008875_abnormal_xenobiotic_pharmacok	3.52167852
7	MP0001666_abnormal_nutrient_absorption	3.07341015
8	MP0008877_abnormal_DNA_methylation	3.06674080
9	MP0003787_abnormal_imprinting	2.46519601
10	MP0006035_abnormal_mitochondrial_morpho	2.38622451
11	MP0001764_abnormal_homeostasis	2.36327849
12	MP0003718_maternal_effect	2.26439935
13	MP0008058_abnormal_DNA_repair	2.24359555
14	MP0006292_abnormal_olfactory_placode	2.23602257
15	MP0004957_abnormal_blastocyst_morpholog	2.15080374
16	MP0001293_anophthalmia	1.89186421
17	MP0005410_abnormal_fertilization	1.84296189
18	MP0006036_abnormal_mitochondrial_physio	1.82664079
19	MP0010094_abnormal_chromosome_stability	1.74324131
20	MP0008872_abnormal_physiological_respon	1.72335274
21	MP0003252_abnormal_bile_duct	1.66464191
22	MP0004264_abnormal_extraembryonic_tissu	1.64795747
23	MP0003186_abnormal_redox_activity	1.64309072
24	MP0005085_abnormal_gallbladder_physiolo	1.60779512
25	MP0003866_abnormal_defecation	1.58508504
26	MP0005332_abnormal_amino_acid	1.57628220
27	MP0003111_abnormal_nucleus_morphology	1.55365351
28	MP0000427_abnormal_hair_cycle	1.50653652
29	MP0010386_abnormal_urinary_bladder	1.47676820
30	MP0005365_abnormal_bile_salt	1.46495679
31	MP0002876_abnormal_thyroid_physiology	1.37574842
32	MP0004019_abnormal_vitamin_homeostasis	1.37048031
33	MP0005670_abnormal_white_adipose	1.33218302
34	MP0002210_abnormal_sex_determination	1.30624288
35	MP0002837_dystrophic_cardiac_calcinosis	1.27599519
36	MP0005408_hypopigmentation	1.26540004
37	MP0008007_abnormal_cellular_replicative	1.26278168
38	MP0002139_abnormal_hepatobiliary_system	1.26079620
39	MP0001661_extended_life_span	1.22036880
40	MP0005501_abnormal_skin_physiology	1.22006296
41	MP0005319_abnormal_enzyme/_coenzyme	1.21555089
42	MP0008932_abnormal_embryonic_tissue	1.19453531
43	MP0001929_abnormal_gametogenesis	1.16282838
44	MP0003786_premature_aging	1.14406844
45	MP0003315_abnormal_perineum_morphology	1.14317974
46	MP0003646_muscle_fatigue	1.12212222
47	MP0000490_abnormal_crypts_of	1.10201666
48	MP0005083_abnormal_biliary_tract	1.10091278
49	MP0000477_abnormal_intestine_morphology	1.07912223
50	MP0001145_abnormal_male_reproductive	1.02802107
51	MP0002277_abnormal_respiratory_mucosa	1.00905805
52	MP0008260_abnormal_autophagy	1.00389286
53	MP0010155_abnormal_intestine_physiology	0.99990235
54	MP0001756_abnormal_urination	0.98429665
55	MP0001765_abnormal_ion_homeostasis	0.97750090
56	MP0000647_abnormal_sebaceous_gland	0.95524708
57	MP0003121_genomic_imprinting	0.95266328
58	MP0005636_abnormal_mineral_homeostasis	0.95160426
59	MP0009643_abnormal_urine_homeostasis	0.94759384
60	MP0003077_abnormal_cell_cycle	0.94234356
61	MP0002736_abnormal_nociception_after	0.93539271
62	MP0000653_abnormal_sex_gland	0.92164247
63	MP0005058_abnormal_lysosome_morphology	0.91829779
64	MP0001119_abnormal_female_reproductive	0.90669721
65	MP0000516_abnormal_urinary_system	0.89295208
66	MP0005367_renal/urinary_system_phenotyp	0.89295208
67	MP0005174_abnormal_tail_pigmentation	0.88895468
68	MP0010771_integument_phenotype	0.87963802
69	MP0010352_gastrointestinal_tract_polyps	0.84985939
70	MP0005389_reproductive_system_phenotype	0.84787300
71	MP0002234_abnormal_pharynx_morphology	0.81894488
72	MP0001919_abnormal_reproductive_system	0.81613138
73	MP0006054_spinal_hemorrhage	0.81101266
74	MP0001485_abnormal_pinna_reflex	0.79612601
75	MP0003567_abnormal_fetal_cardiomyocyte	0.78653213
76	MP0002928_abnormal_bile_duct	0.78506850
77	MP0002796_impaired_skin_barrier	0.76592743
78	MP0009765_abnormal_xenobiotic_induced	0.76529681
79	MP0004142_abnormal_muscle_tone	0.76493027
80	MP0001727_abnormal_embryo_implantation	0.76043897
81	MP0006082_CNS_inflammation	0.75976004
82	MP0000538_abnormal_urinary_bladder	0.75847253
83	MP0002102_abnormal_ear_morphology	0.75681015
84	MP0001529_abnormal_vocalization	0.73932836
85	MP0005671_abnormal_response_to	0.73858037
86	MP0003698_abnormal_male_reproductive	0.73298339
87	MP0004381_abnormal_hair_follicle	0.72175538
88	MP0008004_abnormal_stomach_pH	0.71740803
89	MP0000358_abnormal_cell_content/	0.71189759
90	MP0002136_abnormal_kidney_physiology	0.70946706
91	MP0005395_other_phenotype	0.70815176
92	MP0002160_abnormal_reproductive_system	0.70468148
93	MP0002877_abnormal_melanocyte_morpholog	0.68283317
94	MP0000627_abnormal_mammary_gland	0.67344062
95	MP0004233_abnormal_muscle_weight	0.67249864
96	MP0002060_abnormal_skin_morphology	0.65226056
97	MP0003119_abnormal_digestive_system	0.65138113
98	MP0002693_abnormal_pancreas_physiology	0.64258156
99	MP0005084_abnormal_gallbladder_morpholo	0.63797717
100	MP0003936_abnormal_reproductive_system	0.62652051

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.23174678
2	Acute encephalopathy (HP:0006846)	3.93435531
3	Abnormal mitochondria in muscle tissue (HP:0008316)	3.85722158
4	Hypoplastic pelvis (HP:0008839)	3.83357348
5	J-shaped sella turcica (HP:0002680)	3.81610652
6	Mitochondrial inheritance (HP:0001427)	3.72907726
7	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.60853250
8	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.60853250
9	Progressive macrocephaly (HP:0004481)	3.56674009
10	Increased CSF lactate (HP:0002490)	3.53965754
11	Facial shape deformation (HP:0011334)	3.36396764
12	Potter facies (HP:0002009)	3.36396764
13	Abnormality of the renal cortex (HP:0011035)	3.35011680
14	Lipid accumulation in hepatocytes (HP:0006561)	3.32297494
15	Renal cortical cysts (HP:0000803)	3.31313678
16	Increased hepatocellular lipid droplets (HP:0006565)	3.17401944
17	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.12834870
18	Abnormality of alanine metabolism (HP:0010916)	3.12834870
19	Hyperalaninemia (HP:0003348)	3.12834870
20	Renal Fanconi syndrome (HP:0001994)	3.11613322
21	Type I transferrin isoform profile (HP:0003642)	3.08110194
22	Congenital, generalized hypertrichosis (HP:0004540)	3.06538080
23	Redundant skin (HP:0001582)	2.99042960
24	Supernumerary spleens (HP:0009799)	2.81759510
25	Abnormal biliary tract physiology (HP:0012439)	2.78668696
26	Bile duct proliferation (HP:0001408)	2.78668696
27	Cerebral edema (HP:0002181)	2.75499547
28	Adrenal hypoplasia (HP:0000835)	2.71645540
29	Reticulocytopenia (HP:0001896)	2.70729205
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.70666783
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.70666783
32	Abnormal protein glycosylation (HP:0012346)	2.70666783
33	Abnormal glycosylation (HP:0012345)	2.70666783
34	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.62308184
35	Hepatocellular necrosis (HP:0001404)	2.61665210
36	Increased intramyocellular lipid droplets (HP:0012240)	2.60783258
37	Abnormality of urine glucose concentration (HP:0011016)	2.60059851
38	Glycosuria (HP:0003076)	2.60059851
39	Abnormality of cells of the erythroid lineage (HP:0012130)	2.59595886
40	Abnormal drinking behavior (HP:0030082)	2.57373408
41	Polydipsia (HP:0001959)	2.57373408
42	Abnormality of B cell number (HP:0010975)	2.54262129
43	Hyperglycinuria (HP:0003108)	2.48433892
44	Lethargy (HP:0001254)	2.48309761
45	Hyperglycinemia (HP:0002154)	2.47087763
46	Leukodystrophy (HP:0002415)	2.46331669
47	Dry hair (HP:0011359)	2.45828573
48	Optic disc pallor (HP:0000543)	2.42740737
49	Lactic acidosis (HP:0003128)	2.42437025
50	Reduced antithrombin III activity (HP:0001976)	2.42173667
51	Increased serum lactate (HP:0002151)	2.41998054
52	CNS demyelination (HP:0007305)	2.40572468
53	Stenosis of the external auditory canal (HP:0000402)	2.38989134
54	Palpitations (HP:0001962)	2.38712066
55	Renal tubular acidosis (HP:0001947)	2.38518231
56	Hepatic necrosis (HP:0002605)	2.37509133
57	Increased muscle lipid content (HP:0009058)	2.36832412
58	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.36722499
59	Reduced subcutaneous adipose tissue (HP:0003758)	2.35490084
60	Amaurosis fugax (HP:0100576)	2.32659010
61	Abnormality of renal resorption (HP:0011038)	2.31654930
62	IgM deficiency (HP:0002850)	2.28890233
63	Abnormality of serum amino acid levels (HP:0003112)	2.27226768
64	Entropion (HP:0000621)	2.22735182
65	Renal tubular dysfunction (HP:0000124)	2.21805996
66	Hyperglycemia (HP:0003074)	2.20428321
67	Respiratory difficulties (HP:0002880)	2.18967295
68	Abnormality of the preputium (HP:0100587)	2.13404586
69	Respiratory failure (HP:0002878)	2.12686371
70	Pancytopenia (HP:0001876)	2.11022608
71	Spontaneous abortion (HP:0005268)	2.07133636
72	Tinnitus (HP:0000360)	2.06707519
73	Exertional dyspnea (HP:0002875)	2.06373098
74	Macrocytic anemia (HP:0001972)	2.05401630
75	Exercise intolerance (HP:0003546)	2.04260438
76	Meckel diverticulum (HP:0002245)	2.02740858
77	Rough bone trabeculation (HP:0100670)	2.02504521
78	Tubulointerstitial fibrosis (HP:0005576)	2.01714754
79	Poor speech (HP:0002465)	2.01417405
80	IgG deficiency (HP:0004315)	2.00418146
81	B lymphocytopenia (HP:0010976)	1.99623149
82	Aplastic anemia (HP:0001915)	1.98999386
83	Abnormality of the renal medulla (HP:0100957)	1.98925671
84	Right ventricular cardiomyopathy (HP:0011663)	1.98254719
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.96863625
86	Abnormal tarsal ossification (HP:0008369)	1.96181339
87	Cerebral hypomyelination (HP:0006808)	1.94292662
88	Proximal tubulopathy (HP:0000114)	1.93599905
89	Abnormality of the ileum (HP:0001549)	1.92979442
90	Bilateral sensorineural hearing impairment (HP:0008619)	1.90322073
91	Abolished electroretinogram (ERG) (HP:0000550)	1.89697989
92	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.89088961
93	Abnormal number of erythroid precursors (HP:0012131)	1.88192026
94	Insulin-resistant diabetes mellitus (HP:0000831)	1.86660818
95	Testicular atrophy (HP:0000029)	1.85822782
96	Thrombocytosis (HP:0001894)	1.84813424
97	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.83705454
98	Polyuria (HP:0000103)	1.82157020
99	Anhidrosis (HP:0000970)	1.81421190
100	Abnormality of glycine metabolism (HP:0010895)	1.80491915

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.88109573
2	EIF2AK1	3.73665468
3	EIF2AK3	3.61145848
4	MAP3K12	3.50093922
5	STK39	3.31535046
6	PDK2	3.03876631
7	WNK4	2.99579591
8	OXSR1	2.86078834
9	VRK2	2.47091355
10	EPHA2	2.44389409
11	PBK	2.39811930
12	TRIM28	2.09934075
13	ZAK	1.99471948
14	RPS6KB2	1.98323445
15	PIK3CA	1.88312636
16	STK16	1.82881518
17	CDC7	1.80884735
18	MST4	1.76755930
19	MAP3K13	1.59170351
20	TXK	1.58502993
21	TLK1	1.56872496
22	NEK1	1.56401068
23	BUB1	1.50223224
24	TESK2	1.40947084
25	MYLK	1.40405494
26	LMTK2	1.34113283
27	BMPR1B	1.25947415
28	GRK1	1.25002633
29	KDR	1.15560194
30	PHKG1	1.15547737
31	PHKG2	1.15547737
32	CHEK2	1.15397740
33	MAP4K2	1.09521883
34	MAPKAPK3	1.08573426
35	AURKB	1.08219484
36	GRK6	1.02839588
37	PRKCI	0.99510783
38	PAK4	0.97001888
39	BMPR2	0.96492240
40	PLK4	0.92561730
41	PNCK	0.91301828
42	VRK1	0.91122261
43	DAPK3	0.89321099
44	DYRK2	0.89029864
45	MAP3K7	0.85077120
46	NME2	0.77716765
47	ADRBK2	0.75865153
48	GRK7	0.74902749
49	AURKA	0.72692097
50	PLK1	0.71986837
51	TESK1	0.71371200
52	WEE1	0.70161323
53	SRPK1	0.68693106
54	CSNK1G3	0.68589106
55	EIF2AK2	0.67667919
56	IKBKB	0.66170251
57	PLK2	0.65750102
58	CDK9	0.64715797
59	CDK19	0.63529995
60	PRKCE	0.57302114
61	ACVR1B	0.57002992
62	NUAK1	0.55317271
63	DAPK1	0.54175742
64	CSNK1G1	0.53891082
65	FRK	0.52592220
66	PRKG2	0.52213792
67	LIMK1	0.52158251
68	MST1R	0.52119062
69	PRKCD	0.50354393
70	MET	0.49971371
71	CSNK2A1	0.49363644
72	TGFBR1	0.48990077
73	CSF1R	0.47430178
74	CSNK1G2	0.47362351
75	PTK2B	0.46593462
76	NME1	0.46155424
77	TTK	0.46113127
78	ILK	0.45732004
79	IGF1R	0.45362969
80	SCYL2	0.45288889
81	ATR	0.45205092
82	PLK3	0.44117406
83	CHEK1	0.43787966
84	CAMK2G	0.43240032
85	CDK7	0.42973743
86	CSNK1A1L	0.42326198
87	ABL2	0.42091238
88	CSNK2A2	0.41986487
89	MAP2K2	0.41473416
90	PRKCQ	0.40272385
91	NEK6	0.39913782
92	MAP3K14	0.39122630
93	ADRBK1	0.38132142
94	PRKCA	0.36750397
95	AKT2	0.34966727
96	CAMK2D	0.34727426
97	TAOK3	0.33363265
98	RIPK4	0.32051655
99	CDK8	0.31677733
100	RPS6KA4	0.31432639

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.76433133
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.47652962
3	Proteasome_Homo sapiens_hsa03050	3.37289023
4	Protein export_Homo sapiens_hsa03060	3.15154069
5	Parkinsons disease_Homo sapiens_hsa05012	2.69051681
6	DNA replication_Homo sapiens_hsa03030	2.59749105
7	RNA polymerase_Homo sapiens_hsa03020	2.49999977
8	Fanconi anemia pathway_Homo sapiens_hsa03460	2.42376349
9	Homologous recombination_Homo sapiens_hsa03440	2.29478733
10	Mismatch repair_Homo sapiens_hsa03430	2.19864277
11	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.15219735
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.10178632
13	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.05262467
14	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.98913216
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.94855939
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.89505255
17	Huntingtons disease_Homo sapiens_hsa05016	1.83972164
18	Alzheimers disease_Homo sapiens_hsa05010	1.68575119
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.66056039
20	One carbon pool by folate_Homo sapiens_hsa00670	1.61363682
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60240004
22	Glutathione metabolism_Homo sapiens_hsa00480	1.54911125
23	Pyrimidine metabolism_Homo sapiens_hsa00240	1.54727546
24	RNA degradation_Homo sapiens_hsa03018	1.50540318
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.48799087
26	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39234925
27	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.35927592
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.35480752
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35286620
30	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.31721479
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.29594289
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.27450028
33	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.26591424
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.20216275
35	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19379432
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.19293081
37	Basal transcription factors_Homo sapiens_hsa03022	1.18861821
38	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.16948479
39	RNA transport_Homo sapiens_hsa03013	1.16246381
40	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.15908109
41	Base excision repair_Homo sapiens_hsa03410	1.15766171
42	Pancreatic secretion_Homo sapiens_hsa04972	1.09323512
43	Nitrogen metabolism_Homo sapiens_hsa00910	1.08988241
44	Spliceosome_Homo sapiens_hsa03040	1.07434683
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.04812286
46	Collecting duct acid secretion_Homo sapiens_hsa04966	1.03825868
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.00643399
48	Propanoate metabolism_Homo sapiens_hsa00640	0.97629119
49	Caffeine metabolism_Homo sapiens_hsa00232	0.94323893
50	Purine metabolism_Homo sapiens_hsa00230	0.94255906
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.93427666
52	Fatty acid elongation_Homo sapiens_hsa00062	0.90219058
53	Peroxisome_Homo sapiens_hsa04146	0.87366952
54	Retinol metabolism_Homo sapiens_hsa00830	0.85688540
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.82424240
56	Metabolic pathways_Homo sapiens_hsa01100	0.82349287
57	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.80298869
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.77134516
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76269779
60	Tryptophan metabolism_Homo sapiens_hsa00380	0.75615933
61	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.75065250
62	Vibrio cholerae infection_Homo sapiens_hsa05110	0.74916321
63	Phototransduction_Homo sapiens_hsa04744	0.72537941
64	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.68317444
65	Protein digestion and absorption_Homo sapiens_hsa04974	0.67497189
66	Rheumatoid arthritis_Homo sapiens_hsa05323	0.66960631
67	Galactose metabolism_Homo sapiens_hsa00052	0.66732979
68	Fatty acid degradation_Homo sapiens_hsa00071	0.65356693
69	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.64377114
70	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.60777214
71	Folate biosynthesis_Homo sapiens_hsa00790	0.60243458
72	Carbon metabolism_Homo sapiens_hsa01200	0.58863910
73	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.58542504
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57966091
75	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.54265092
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.53707249
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52396188
78	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.51436908
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.51159380
80	Non-homologous end-joining_Homo sapiens_hsa03450	0.51027728
81	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49643453
82	Sulfur metabolism_Homo sapiens_hsa00920	0.49529555
83	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49042418
84	Pyruvate metabolism_Homo sapiens_hsa00620	0.46395135
85	Butanoate metabolism_Homo sapiens_hsa00650	0.45723447
86	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.45555974
87	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.44038370
88	Mineral absorption_Homo sapiens_hsa04978	0.39027443
89	Pentose phosphate pathway_Homo sapiens_hsa00030	0.38893730
90	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.38686012
91	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.38354838
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.37759457
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35932645
94	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33022031
95	Cell cycle_Homo sapiens_hsa04110	0.32821422
96	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.32519473
97	Histidine metabolism_Homo sapiens_hsa00340	0.31607813
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.29268462
99	Arginine biosynthesis_Homo sapiens_hsa00220	0.28340531
100	Antigen processing and presentation_Homo sapiens_hsa04612	0.28335684

KRT18P19

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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