ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	artery smooth muscle contraction (GO:0014824)	5.42207529
2	regulation of bile acid biosynthetic process (GO:0070857)	4.95437094
3	synapsis (GO:0007129)	4.82947064
4	male meiosis I (GO:0007141)	4.63947518
5	tonic smooth muscle contraction (GO:0014820)	4.63329096
6	proteasome assembly (GO:0043248)	4.62664969
7	chromosome organization involved in meiosis (GO:0070192)	4.46993571
8	DNA replication-dependent nucleosome organization (GO:0034723)	4.43394891
9	DNA replication-dependent nucleosome assembly (GO:0006335)	4.43394891
10	meiosis I (GO:0007127)	4.15360417
11	synaptonemal complex assembly (GO:0007130)	4.15066955
12	prostanoid biosynthetic process (GO:0046457)	4.01828098
13	prostaglandin biosynthetic process (GO:0001516)	4.01828098
14	regulation of cellular respiration (GO:0043457)	4.01101162
15	ribosome biogenesis (GO:0042254)	3.77894189
16	hindbrain development (GO:0030902)	3.73217849
17	L-serine metabolic process (GO:0006563)	3.66700620
18	DNA replication checkpoint (GO:0000076)	3.65990414
19	synaptonemal complex organization (GO:0070193)	3.64783014
20	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.60974950
21	regulation of mitochondrial translation (GO:0070129)	3.55927490
22	chaperone-mediated protein transport (GO:0072321)	3.51214997
23	DNA synthesis involved in DNA repair (GO:0000731)	3.50585082
24	regulation of cellular amino acid metabolic process (GO:0006521)	3.38191482
25	daunorubicin metabolic process (GO:0044597)	3.35287519
26	polyketide metabolic process (GO:0030638)	3.35287519
27	doxorubicin metabolic process (GO:0044598)	3.35287519
28	pyrimidine-containing compound transmembrane transport (GO:0072531)	3.34606989
29	piRNA metabolic process (GO:0034587)	3.31841533
30	mitotic metaphase plate congression (GO:0007080)	3.31221576
31	ribosomal small subunit assembly (GO:0000028)	3.31168442
32	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.30893536
33	ribosomal large subunit biogenesis (GO:0042273)	3.30878316
34	uterus development (GO:0060065)	3.30503906
35	rRNA transcription (GO:0009303)	3.28378090
36	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.26923652
37	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.26596066
38	L-phenylalanine metabolic process (GO:0006558)	3.25341534
39	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.25341534
40	seminiferous tubule development (GO:0072520)	3.25117465
41	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.24710212
42	xenobiotic catabolic process (GO:0042178)	3.24519481
43	positive regulation of cellular amine metabolic process (GO:0033240)	3.23804684
44	prostaglandin metabolic process (GO:0006693)	3.22539332
45	prostanoid metabolic process (GO:0006692)	3.22539332
46	ribonucleoprotein complex biogenesis (GO:0022613)	3.18202804
47	water-soluble vitamin biosynthetic process (GO:0042364)	3.15851821
48	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.15083411
49	ribosome assembly (GO:0042255)	3.12725995
50	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.08908418
51	galactose catabolic process (GO:0019388)	3.08367879
52	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.06327318
53	nucleoside transmembrane transport (GO:1901642)	3.06153255
54	meiotic nuclear division (GO:0007126)	3.05576770
55	cellular component biogenesis (GO:0044085)	3.03434761
56	ncRNA 3-end processing (GO:0043628)	3.01376028
57	formation of translation preinitiation complex (GO:0001731)	2.99942089
58	protein autoprocessing (GO:0016540)	2.96238727
59	pseudouridine synthesis (GO:0001522)	2.96213246
60	L-methionine salvage (GO:0071267)	2.95940228
61	L-methionine biosynthetic process (GO:0071265)	2.95940228
62	amino acid salvage (GO:0043102)	2.95940228
63	aminoglycoside antibiotic metabolic process (GO:0030647)	2.93755109
64	pteridine-containing compound biosynthetic process (GO:0042559)	2.92941221
65	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.92700816
66	negative regulation of ligase activity (GO:0051352)	2.92700816
67	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.92250698
68	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.90782436
69	serine family amino acid biosynthetic process (GO:0009070)	2.89209796
70	DNA strand elongation involved in DNA replication (GO:0006271)	2.88576624
71	CENP-A containing nucleosome assembly (GO:0034080)	2.87939023
72	cyclooxygenase pathway (GO:0019371)	2.84365231
73	regulation of oxidative phosphorylation (GO:0002082)	2.82811001
74	positive regulation of ligase activity (GO:0051351)	2.82531150
75	rRNA modification (GO:0000154)	2.82459052
76	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.81266447
77	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.81266447
78	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.80690236
79	ATP synthesis coupled proton transport (GO:0015986)	2.80690236
80	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.80171652
81	GTP biosynthetic process (GO:0006183)	2.79454286
82	chromatin remodeling at centromere (GO:0031055)	2.79212947
83	regulation of cellular amine metabolic process (GO:0033238)	2.79131475
84	termination of RNA polymerase I transcription (GO:0006363)	2.79088308
85	protein maturation by protein folding (GO:0022417)	2.78954717
86	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.78953058
87	vascular smooth muscle contraction (GO:0014829)	2.78591767
88	tRNA aminoacylation for protein translation (GO:0006418)	2.77690046
89	nucleoside transport (GO:0015858)	2.76525202
90	tongue development (GO:0043586)	2.76371773
91	DNA strand elongation (GO:0022616)	2.76285799
92	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.76104123
93	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.76104123
94	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.76104123
95	metaphase plate congression (GO:0051310)	2.75215463
96	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.75169345
97	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.75169345
98	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.75008916
99	meiotic cell cycle process (GO:1903046)	2.72717429
100	amino acid activation (GO:0043038)	2.70979462

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.77407481
2	E2F7_22180533_ChIP-Seq_HELA_Human	4.65693157
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.00072530
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.74970385
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.62643896
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.43459282
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.26220534
8	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.16383889
9	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.99509682
10	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.81214785
11	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.75380522
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.70317759
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.65146067
14	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.62430766
15	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.57948500
16	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.46182630
17	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.37141573
18	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.34643490
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.32581617
20	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.31009099
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.30613248
22	AR_21909140_ChIP-Seq_LNCAP_Human	2.28963498
23	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.26121043
24	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.21814315
25	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	2.18089789
26	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.14702507
27	DCP1A_22483619_ChIP-Seq_HELA_Human	2.14166922
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.06518804
29	ZNF263_19887448_ChIP-Seq_K562_Human	2.02502528
30	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.01511179
31	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.00968700
32	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.99010719
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.95606643
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.92474096
35	XRN2_22483619_ChIP-Seq_HELA_Human	1.87764927
36	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.87663634
37	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.82944564
38	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.80700723
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.79228030
40	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.68729617
41	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.67417641
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67336366
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.62779193
44	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.59400193
45	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.56811502
46	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.54025711
47	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.53585649
48	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.50455873
49	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.49455226
50	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.43891567
51	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.43888939
52	FOXP3_21729870_ChIP-Seq_TREG_Human	1.42506443
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.41902518
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.41582751
55	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.40961245
56	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.40901101
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35914440
58	VDR_23849224_ChIP-Seq_CD4+_Human	1.34970980
59	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.33926304
60	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.32932699
61	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.32071478
62	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.28963881
63	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28740040
64	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.25764444
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.23614953
66	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.22388785
67	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.21455187
68	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.20930354
69	GATA4_25053715_ChIP-Seq_YYC3_Human	1.20896147
70	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.16656750
71	MYC_18940864_ChIP-ChIP_HL60_Human	1.14704905
72	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.12183059
73	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.12165915
74	KDM5A_27292631_Chip-Seq_BREAST_Human	1.11498511
75	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.11350784
76	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.10576425
77	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.07895913
78	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.07312625
79	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.05535822
80	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.04958946
81	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.04592034
82	GATA6_25053715_ChIP-Seq_YYC3_Human	1.00228276
83	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.99527301
84	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.96987454
85	ELK1_19687146_ChIP-ChIP_HELA_Human	0.92896352
86	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.88687727
87	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.87644562
88	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.85787319
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84805771
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.84168322
91	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.82935192
92	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.81999521
93	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.81354508
94	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.81007680
95	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.80529863
96	FOXM1_23109430_ChIP-Seq_U2OS_Human	0.80178286
97	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.80004620
98	SOX2_18692474_ChIP-Seq_MESCs_Mouse	0.77381425
99	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.76526405
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.76119642

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.54383105
2	MP0001666_abnormal_nutrient_absorption	3.43814755
3	MP0003693_abnormal_embryo_hatching	3.42357002
4	MP0004957_abnormal_blastocyst_morpholog	3.38395469
5	MP0008875_abnormal_xenobiotic_pharmacok	2.75841370
6	MP0008058_abnormal_DNA_repair	2.75441518
7	MP0005187_abnormal_penis_morphology	2.74568183
8	MP0003315_abnormal_perineum_morphology	2.73107954
9	MP0005365_abnormal_bile_salt	2.73052685
10	MP0003111_abnormal_nucleus_morphology	2.66512619
11	MP0003868_abnormal_feces_composition	2.41257613
12	MP0002139_abnormal_hepatobiliary_system	2.22634615
13	MP0008872_abnormal_physiological_respon	2.17984417
14	MP0003806_abnormal_nucleotide_metabolis	2.01225489
15	MP0010094_abnormal_chromosome_stability	2.00535277
16	MP0000490_abnormal_crypts_of	2.00026596
17	MP0003718_maternal_effect	1.95833702
18	MP0010234_abnormal_vibrissa_follicle	1.95148152
19	MP0003119_abnormal_digestive_system	1.93801308
20	MP0005389_reproductive_system_phenotype	1.84890671
21	MP0002210_abnormal_sex_determination	1.82298677
22	MP0001919_abnormal_reproductive_system	1.81760665
23	MP0004019_abnormal_vitamin_homeostasis	1.78817805
24	MP0002796_impaired_skin_barrier	1.73653865
25	MP0005360_urolithiasis	1.73510033
26	MP0010352_gastrointestinal_tract_polyps	1.71798353
27	MP0000647_abnormal_sebaceous_gland	1.71764978
28	MP0005451_abnormal_body_composition	1.68337769
29	MP0003878_abnormal_ear_physiology	1.66792650
30	MP0005377_hearing/vestibular/ear_phenot	1.66792650
31	MP0005084_abnormal_gallbladder_morpholo	1.63774316
32	MP0006054_spinal_hemorrhage	1.62618995
33	MP0002160_abnormal_reproductive_system	1.61120078
34	MP0005085_abnormal_gallbladder_physiolo	1.60295787
35	MP0001929_abnormal_gametogenesis	1.59491433
36	MP0006035_abnormal_mitochondrial_morpho	1.55561682
37	MP0001764_abnormal_homeostasis	1.46461973
38	MP0003186_abnormal_redox_activity	1.44874689
39	MP0001145_abnormal_male_reproductive	1.42736678
40	MP0001730_embryonic_growth_arrest	1.39097145
41	MP0008004_abnormal_stomach_pH	1.37876825
42	MP0006292_abnormal_olfactory_placode	1.36576356
43	MP0003195_calcinosis	1.33816719
44	MP0000653_abnormal_sex_gland	1.30456210
45	MP0008877_abnormal_DNA_methylation	1.29104511
46	MP0005220_abnormal_exocrine_pancreas	1.28162090
47	MP0005670_abnormal_white_adipose	1.27349922
48	MP0008932_abnormal_embryonic_tissue	1.25637337
49	MP0003941_abnormal_skin_development	1.25452384
50	MP0003786_premature_aging	1.23783238
51	MP0000358_abnormal_cell_content/	1.22437929
52	MP0001968_abnormal_touch/_nociception	1.21684425
53	MP0000427_abnormal_hair_cycle	1.18780918
54	MP0010386_abnormal_urinary_bladder	1.18737293
55	MP0005332_abnormal_amino_acid	1.18218017
56	MP0009379_abnormal_foot_pigmentation	1.17441047
57	MP0004147_increased_porphyrin_level	1.16398896
58	MP0003077_abnormal_cell_cycle	1.16180004
59	MP0006036_abnormal_mitochondrial_physio	1.15802637
60	MP0000566_synostosis	1.15602069
61	MP0002098_abnormal_vibrissa_morphology	1.13376406
62	MP0001697_abnormal_embryo_size	1.13070176
63	MP0003698_abnormal_male_reproductive	1.12053039
64	MP0005501_abnormal_skin_physiology	1.10305367
65	MP0003890_abnormal_embryonic-extraembry	1.09697080
66	MP0002735_abnormal_chemical_nociception	1.07152508
67	MP0003866_abnormal_defecation	1.05257709
68	MP0005319_abnormal_enzyme/_coenzyme	1.04847295
69	MP0005380_embryogenesis_phenotype	1.03914364
70	MP0001672_abnormal_embryogenesis/_devel	1.03914364
71	MP0005636_abnormal_mineral_homeostasis	1.02336542
72	MP0003123_paternal_imprinting	1.02228349
73	MP0001119_abnormal_female_reproductive	1.01114685
74	MP0009672_abnormal_birth_weight	0.99080534
75	MP0003329_amyloid_beta_deposits	0.98140992
76	MP0002085_abnormal_embryonic_tissue	0.96298684
77	MP0002161_abnormal_fertility/fecundity	0.95484205
78	MP0004264_abnormal_extraembryonic_tissu	0.94593806
79	MP0002080_prenatal_lethality	0.92261323
80	MP0005410_abnormal_fertilization	0.90079085
81	MP0000537_abnormal_urethra_morphology	0.89848297
82	MP0001661_extended_life_span	0.87028610
83	MP0002938_white_spotting	0.86916781
84	MP0010329_abnormal_lipoprotein_level	0.86776886
85	MP0001915_intracranial_hemorrhage	0.86550462
86	MP0002090_abnormal_vision	0.83101753
87	MP0003959_abnormal_lean_body	0.82747985
88	MP0004133_heterotaxia	0.82310667
89	MP0002254_reproductive_system_inflammat	0.82116174
90	MP0003699_abnormal_female_reproductive	0.82006217
91	MP0001873_stomach_inflammation	0.81287876
92	MP0002089_abnormal_postnatal_growth/wei	0.80095340
93	MP0002111_abnormal_tail_morphology	0.79878841
94	MP0003984_embryonic_growth_retardation	0.78634882
95	MP0002088_abnormal_embryonic_growth/wei	0.78605740
96	MP0003936_abnormal_reproductive_system	0.75270698
97	MP0000538_abnormal_urinary_bladder	0.74341079
98	MP0009643_abnormal_urine_homeostasis	0.74269647
99	MP0001529_abnormal_vocalization	0.73862376
100	MP0003252_abnormal_bile_duct	0.71783501

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	4.84687727
2	Abnormality of alanine metabolism (HP:0010916)	4.84687727
3	Hyperalaninemia (HP:0003348)	4.84687727
4	Chronic otitis media (HP:0000389)	4.01932541
5	Gonadotropin excess (HP:0000837)	3.94542483
6	Renal tubular acidosis (HP:0001947)	3.85575724
7	Vascular calcification (HP:0004934)	3.80977093
8	Acute necrotizing encephalopathy (HP:0006965)	3.58007544
9	Acute encephalopathy (HP:0006846)	3.38441146
10	Increased serum pyruvate (HP:0003542)	3.34796418
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.30807902
12	Abnormal respiratory motile cilium morphology (HP:0005938)	3.26218390
13	Abnormal respiratory epithelium morphology (HP:0012253)	3.26218390
14	Cardiovascular calcification (HP:0011915)	3.21892718
15	Abnormality of glycolysis (HP:0004366)	3.09226417
16	Microvesicular hepatic steatosis (HP:0001414)	2.98567726
17	Renal tubular dysfunction (HP:0000124)	2.98243777
18	Birth length less than 3rd percentile (HP:0003561)	2.94762734
19	Abnormality of serum amino acid levels (HP:0003112)	2.91834634
20	Aplastic anemia (HP:0001915)	2.90636928
21	Cerebral edema (HP:0002181)	2.85381605
22	Increased CSF lactate (HP:0002490)	2.82495728
23	Abnormality of magnesium homeostasis (HP:0004921)	2.79648218
24	Progressive macrocephaly (HP:0004481)	2.77743063
25	Upper limb muscle weakness (HP:0003484)	2.66780728
26	Chronic sinusitis (HP:0011109)	2.66425648
27	Hyperglycinemia (HP:0002154)	2.64394587
28	Mitochondrial inheritance (HP:0001427)	2.63170487
29	Hepatic necrosis (HP:0002605)	2.61220478
30	Bicornuate uterus (HP:0000813)	2.58851761
31	Type I transferrin isoform profile (HP:0003642)	2.55461840
32	Hypomagnesemia (HP:0002917)	2.54593491
33	Proximal tubulopathy (HP:0000114)	2.51743180
34	Increased serum lactate (HP:0002151)	2.51159271
35	Lipid accumulation in hepatocytes (HP:0006561)	2.47455573
36	Hepatocellular necrosis (HP:0001404)	2.45786367
37	Micronodular cirrhosis (HP:0001413)	2.43619017
38	Lethargy (HP:0001254)	2.41572118
39	Lactic acidosis (HP:0003128)	2.38164196
40	Steatorrhea (HP:0002570)	2.36412791
41	Cerebral hypomyelination (HP:0006808)	2.35300746
42	Osteomalacia (HP:0002749)	2.33756170
43	Sparse eyelashes (HP:0000653)	2.32030401
44	Fat malabsorption (HP:0002630)	2.29759802
45	Bilateral sensorineural hearing impairment (HP:0008619)	2.29365717
46	Respiratory failure (HP:0002878)	2.29034298
47	Hypobetalipoproteinemia (HP:0003563)	2.28501158
48	Adrenal hypoplasia (HP:0000835)	2.26960631
49	Paralysis (HP:0003470)	2.25039336
50	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	2.24206705
51	Abnormality of glycine metabolism (HP:0010895)	2.20029583
52	Abnormality of serine family amino acid metabolism (HP:0010894)	2.20029583
53	Testicular atrophy (HP:0000029)	2.19525349
54	Azoospermia (HP:0000027)	2.18808478
55	Microretrognathia (HP:0000308)	2.18089243
56	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.16540379
57	Hyperammonemia (HP:0001987)	2.14607231
58	Abnormality of methionine metabolism (HP:0010901)	2.14044239
59	Abnormal number of erythroid precursors (HP:0012131)	2.13326992
60	Clitoromegaly (HP:0000057)	2.13051874
61	Hypoglycemic coma (HP:0001325)	2.10496878
62	CNS demyelination (HP:0007305)	2.10458268
63	Abnormality of urine glucose concentration (HP:0011016)	2.10455674
64	Glycosuria (HP:0003076)	2.10455674
65	CNS hypomyelination (HP:0003429)	2.09053026
66	Reduced antithrombin III activity (HP:0001976)	2.03046136
67	Abnormality of proline metabolism (HP:0010907)	2.02088759
68	Hydroxyprolinuria (HP:0003080)	2.02088759
69	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.00640631
70	Tetany (HP:0001281)	2.00468719
71	Patent foramen ovale (HP:0001655)	1.99366264
72	Abnormality of fatty-acid metabolism (HP:0004359)	1.98703591
73	Leukodystrophy (HP:0002415)	1.97575926
74	Hypophosphatemic rickets (HP:0004912)	1.97025429
75	Intrahepatic cholestasis (HP:0001406)	1.96352284
76	Rough bone trabeculation (HP:0100670)	1.95807879
77	Amelogenesis imperfecta (HP:0000705)	1.95120104
78	Multiple enchondromatosis (HP:0005701)	1.92130696
79	Parakeratosis (HP:0001036)	1.89707219
80	Abnormality of cells of the erythroid lineage (HP:0012130)	1.89065755
81	Abnormal spermatogenesis (HP:0008669)	1.88228358
82	Abnormal protein N-linked glycosylation (HP:0012347)	1.87376172
83	Abnormal protein glycosylation (HP:0012346)	1.87376172
84	Abnormal glycosylation (HP:0012345)	1.87376172
85	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87376172
86	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.87259059
87	Hyperglycinuria (HP:0003108)	1.85903733
88	Dicarboxylic aciduria (HP:0003215)	1.85366552
89	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.85366552
90	Spastic diplegia (HP:0001264)	1.85194315
91	Septate vagina (HP:0001153)	1.84988577
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.83914226
93	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.83914226
94	Increased circulating renin level (HP:0000848)	1.83174795
95	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.82485116
96	Opisthotonus (HP:0002179)	1.81904805
97	Back pain (HP:0003418)	1.81636426
98	Prolonged neonatal jaundice (HP:0006579)	1.81009173
99	Hepatocellular carcinoma (HP:0001402)	1.80509372
100	Vacuolated lymphocytes (HP:0001922)	1.80351103

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	4.36539385
2	PBK	4.28956434
3	ZAK	4.17764793
4	PDK2	3.76203424
5	EPHA2	3.69998107
6	STK39	3.58006386
7	OXSR1	3.19022100
8	CASK	3.13347913
9	BUB1	3.00831509
10	VRK2	2.77752599
11	WNK4	2.76513072
12	INSRR	2.28150772
13	VRK1	2.21333971
14	RPS6KB2	2.11688002
15	PLK4	2.09433847
16	MST4	1.87512722
17	SMG1	1.81379402
18	STK16	1.74831976
19	NME2	1.73238537
20	PIK3CA	1.67653894
21	EIF2AK1	1.63574989
22	NEK1	1.51179302
23	CDK19	1.41570429
24	PAK4	1.40668361
25	AURKA	1.36212194
26	CDC7	1.35356865
27	ICK	1.29895183
28	DAPK3	1.26861686
29	DAPK1	1.22579107
30	PLK1	1.12498851
31	SRPK1	1.07120551
32	RPS6KA5	1.06934682
33	TESK1	1.04530034
34	EIF2AK3	1.02315876
35	AURKB	0.97094933
36	AKT2	0.95021220
37	PTK6	0.93521960
38	CAMK2G	0.92878602
39	TTK	0.88612348
40	WEE1	0.86094796
41	STK4	0.83478813
42	CHEK2	0.83371558
43	LIMK1	0.83093312
44	MAP3K8	0.80869685
45	CAMK2D	0.78769548
46	NME1	0.77917892
47	TSSK6	0.76432108
48	CAMK2B	0.73564726
49	SCYL2	0.73302260
50	GRK1	0.73286360
51	TAF1	0.72569246
52	MAP3K12	0.71037680
53	MAP2K2	0.70974682
54	PRKCI	0.70683526
55	PLK3	0.67509053
56	CDK9	0.67026266
57	ABL2	0.66819642
58	PLK2	0.66691330
59	NUAK1	0.66276447
60	ATR	0.63971380
61	TRIM28	0.62690172
62	LMTK2	0.61337001
63	BCKDK	0.60628524
64	ERBB4	0.57727176
65	MYLK	0.55560661
66	CDK7	0.50172300
67	CHEK1	0.48065730
68	ILK	0.47640414
69	TESK2	0.47056508
70	TNIK	0.44514601
71	CSNK1G3	0.41713007
72	PRKCE	0.41146074
73	EIF2AK2	0.40492689
74	FER	0.37910488
75	MAP3K11	0.37364304
76	PAK1	0.36346987
77	BRAF	0.34866276
78	MELK	0.34780087
79	CSNK1E	0.33734189
80	CAMK4	0.33623995
81	MAP3K13	0.32916381
82	NEK9	0.32784131
83	ERBB2	0.32093523
84	CHUK	0.31162075
85	CSNK2A2	0.30645665
86	PRKCG	0.30575571
87	STK10	0.29898587
88	PKN1	0.27101008
89	BRSK1	0.26794876
90	CSNK1A1L	0.26705085
91	PRKCD	0.26655695
92	ERN1	0.24893403
93	CSNK2A1	0.24405682
94	ADRBK2	0.23236811
95	MST1R	0.23199404
96	PIM1	0.21775559
97	CAMK1	0.21490413
98	CAMK2A	0.19479156
99	CDK1	0.19443771
100	PRKCA	0.18653950

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.67401769
2	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.62855871
3	RNA polymerase_Homo sapiens_hsa03020	2.38010816
4	DNA replication_Homo sapiens_hsa03030	2.36557183
5	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.30497922
6	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.30227954
7	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.19191395
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.10161896
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.02294768
10	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.00557484
11	Ribosome_Homo sapiens_hsa03010	1.97544723
12	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94015729
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.93687506
14	Fatty acid elongation_Homo sapiens_hsa00062	1.85330274
15	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.76030652
16	Mismatch repair_Homo sapiens_hsa03430	1.75768283
17	Arginine biosynthesis_Homo sapiens_hsa00220	1.73659618
18	Sulfur relay system_Homo sapiens_hsa04122	1.73357573
19	Alcoholism_Homo sapiens_hsa05034	1.68999233
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.67416409
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.63106028
22	Parkinsons disease_Homo sapiens_hsa05012	1.57456876
23	One carbon pool by folate_Homo sapiens_hsa00670	1.56934621
24	Folate biosynthesis_Homo sapiens_hsa00790	1.56270083
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.56021864
26	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53973592
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.52343504
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.49018528
29	Carbon metabolism_Homo sapiens_hsa01200	1.48919534
30	Glutathione metabolism_Homo sapiens_hsa00480	1.44584719
31	Base excision repair_Homo sapiens_hsa03410	1.43641398
32	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.43403082
33	RNA transport_Homo sapiens_hsa03013	1.43295344
34	Homologous recombination_Homo sapiens_hsa03440	1.42991021
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.38210078
36	Steroid biosynthesis_Homo sapiens_hsa00100	1.37121229
37	Sulfur metabolism_Homo sapiens_hsa00920	1.36207155
38	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.33690762
39	Huntingtons disease_Homo sapiens_hsa05016	1.30413338
40	Non-homologous end-joining_Homo sapiens_hsa03450	1.30329245
41	Fatty acid degradation_Homo sapiens_hsa00071	1.29437782
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.29296081
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.24088526
44	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.18788001
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.17150676
46	Fatty acid metabolism_Homo sapiens_hsa01212	1.17098962
47	Vibrio cholerae infection_Homo sapiens_hsa05110	1.17038814
48	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.16378195
49	Spliceosome_Homo sapiens_hsa03040	1.11327757
50	Nucleotide excision repair_Homo sapiens_hsa03420	1.10723761
51	Arginine and proline metabolism_Homo sapiens_hsa00330	1.07270511
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.07100591
53	Basal transcription factors_Homo sapiens_hsa03022	1.06776258
54	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06533921
55	Pancreatic secretion_Homo sapiens_hsa04972	1.04942604
56	Propanoate metabolism_Homo sapiens_hsa00640	0.99904753
57	Tryptophan metabolism_Homo sapiens_hsa00380	0.93908074
58	Peroxisome_Homo sapiens_hsa04146	0.93529464
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.92554053
60	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.91578856
61	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.90694320
62	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.89749803
63	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.88368245
64	Cell cycle_Homo sapiens_hsa04110	0.88221416
65	Pentose phosphate pathway_Homo sapiens_hsa00030	0.87766147
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.86496722
67	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.82749419
68	Fanconi anemia pathway_Homo sapiens_hsa03460	0.82600588
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.82514509
70	Metabolic pathways_Homo sapiens_hsa01100	0.80807189
71	Purine metabolism_Homo sapiens_hsa00230	0.79493179
72	Phenylalanine metabolism_Homo sapiens_hsa00360	0.79194619
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.79037624
74	RNA degradation_Homo sapiens_hsa03018	0.78383391
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76454137
76	Histidine metabolism_Homo sapiens_hsa00340	0.75942457
77	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73779122
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73607853
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.72638673
80	Caffeine metabolism_Homo sapiens_hsa00232	0.70425723
81	Tyrosine metabolism_Homo sapiens_hsa00350	0.67694908
82	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.64443824
83	Alzheimers disease_Homo sapiens_hsa05010	0.63035589
84	Viral carcinogenesis_Homo sapiens_hsa05203	0.62743728
85	Protein digestion and absorption_Homo sapiens_hsa04974	0.61833724
86	Galactose metabolism_Homo sapiens_hsa00052	0.60163857
87	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.59804667
88	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57941846
89	Cardiac muscle contraction_Homo sapiens_hsa04260	0.55776560
90	Retinol metabolism_Homo sapiens_hsa00830	0.54689513
91	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.53248263
92	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52736167
93	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.49885090
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.47616628
95	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47253120
96	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.46364562
97	Tight junction_Homo sapiens_hsa04530	0.46011946
98	Protein export_Homo sapiens_hsa03060	0.44667652
99	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.41841744
100	Butanoate metabolism_Homo sapiens_hsa00650	0.34359791

KRT18P20

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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