ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	8.15840938
2	folic acid-containing compound biosynthetic process (GO:0009396)	7.88998842
3	regulation of plasminogen activation (GO:0010755)	6.99523217
4	cysteine metabolic process (GO:0006534)	6.91872033
5	sulfur amino acid catabolic process (GO:0000098)	6.83865648
6	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	6.71492812
7	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	6.71492812
8	folic acid metabolic process (GO:0046655)	5.89281219
9	purine nucleotide salvage (GO:0032261)	5.83491951
10	cochlea development (GO:0090102)	5.75791010
11	L-serine metabolic process (GO:0006563)	5.73850856
12	desmosome organization (GO:0002934)	5.70194987
13	pteridine-containing compound biosynthetic process (GO:0042559)	5.67846842
14	white fat cell differentiation (GO:0050872)	5.59582661
15	adenosine metabolic process (GO:0046085)	5.51549399
16	protein-cofactor linkage (GO:0018065)	5.50704314
17	mitochondrial RNA metabolic process (GO:0000959)	5.41211094
18	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.31718200
19	serine family amino acid biosynthetic process (GO:0009070)	5.12270177
20	folic acid transport (GO:0015884)	5.06044558
21	regulation of gonadotropin secretion (GO:0032276)	4.72329243
22	folic acid-containing compound metabolic process (GO:0006760)	4.67491010
23	rRNA methylation (GO:0031167)	4.63199813
24	inner ear receptor cell development (GO:0060119)	4.62201200
25	negative regulation of DNA biosynthetic process (GO:2000279)	4.62142164
26	galactose catabolic process (GO:0019388)	4.61259667
27	microtubule nucleation (GO:0007020)	4.53613402
28	rRNA modification (GO:0000154)	4.53195608
29	nucleoside transmembrane transport (GO:1901642)	4.34432785
30	galactose metabolic process (GO:0006012)	4.30484834
31	positive regulation of endothelial cell differentiation (GO:0045603)	4.25159805
32	ncRNA 3-end processing (GO:0043628)	4.21397009
33	aminoglycoside antibiotic metabolic process (GO:0030647)	4.20635191
34	alternative mRNA splicing, via spliceosome (GO:0000380)	4.17069025
35	IMP biosynthetic process (GO:0006188)	4.09545129
36	innervation (GO:0060384)	4.01035753
37	inner mitochondrial membrane organization (GO:0007007)	3.96152604
38	pteridine-containing compound metabolic process (GO:0042558)	3.96071060
39	tetrahydrofolate metabolic process (GO:0046653)	3.93861860
40	negative regulation of keratinocyte proliferation (GO:0010839)	3.91345995
41	pseudouridine synthesis (GO:0001522)	3.90838612
42	heme transport (GO:0015886)	3.90831033
43	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)	3.82066219
44	cartilage morphogenesis (GO:0060536)	3.81514602
45	phosphatidylglycerol biosynthetic process (GO:0006655)	3.80111460
46	protein-chromophore linkage (GO:0018298)	3.79262349
47	ribosomal small subunit biogenesis (GO:0042274)	3.74823980
48	sulfur amino acid biosynthetic process (GO:0000097)	3.74217595
49	negative regulation of catenin import into nucleus (GO:0035414)	3.72180455
50	cell migration involved in heart development (GO:0060973)	3.66373245
51	cellular protein complex localization (GO:0034629)	3.64088010
52	CENP-A containing nucleosome assembly (GO:0034080)	3.60211777
53	nucleotide salvage (GO:0043173)	3.55716560
54	energy homeostasis (GO:0097009)	3.54065371
55	glycoside metabolic process (GO:0016137)	3.53831154
56	tRNA modification (GO:0006400)	3.51384034
57	ribosome biogenesis (GO:0042254)	3.49871715
58	artery smooth muscle contraction (GO:0014824)	3.48967360
59	chromatin remodeling at centromere (GO:0031055)	3.42167713
60	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.37670977
61	IMP metabolic process (GO:0046040)	3.35674572
62	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.31501722
63	negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)	3.26892296
64	regulation of vitamin D biosynthetic process (GO:0060556)	3.26334078
65	G-protein coupled receptor internalization (GO:0002031)	3.25622231
66	serine family amino acid catabolic process (GO:0009071)	3.25316253
67	histone H4-K12 acetylation (GO:0043983)	3.22113180
68	ATP hydrolysis coupled proton transport (GO:0015991)	3.20876333
69	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.20876333
70	negative regulation of Ras GTPase activity (GO:0034261)	3.18143564
71	viral transcription (GO:0019083)	3.16678654
72	response to vitamin A (GO:0033189)	3.14810037
73	nucleoside transport (GO:0015858)	3.12776466
74	regulation of tight junction assembly (GO:2000810)	3.12307182
75	polyamine biosynthetic process (GO:0006596)	3.10940300
76	regulation of sequestering of triglyceride (GO:0010889)	3.09373555
77	primary amino compound metabolic process (GO:1901160)	3.06240005
78	translational termination (GO:0006415)	3.05735277
79	ribonucleoprotein complex biogenesis (GO:0022613)	3.05321601
80	tRNA processing (GO:0008033)	3.04615507
81	regulation of vitamin metabolic process (GO:0030656)	3.04292007
82	pathway-restricted SMAD protein phosphorylation (GO:0060389)	3.03455133
83	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.01789836
84	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.01789836
85	NADH dehydrogenase complex assembly (GO:0010257)	3.01789836
86	positive regulation of fatty acid oxidation (GO:0046321)	2.99062178
87	DNA replication-independent nucleosome organization (GO:0034724)	2.97312450
88	DNA replication-independent nucleosome assembly (GO:0006336)	2.97312450
89	transferrin transport (GO:0033572)	2.97111512
90	transcription from mitochondrial promoter (GO:0006390)	2.95736743
91	one-carbon metabolic process (GO:0006730)	2.95167692
92	tonic smooth muscle contraction (GO:0014820)	2.95002970
93	polyamine metabolic process (GO:0006595)	2.93848236
94	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.86443465
95	proteasome assembly (GO:0043248)	2.83137989
96	cellular component biogenesis (GO:0044085)	2.81960979
97	sulfur amino acid metabolic process (GO:0000096)	2.81549716
98	translational elongation (GO:0006414)	2.80989487
99	regulation of endothelial cell differentiation (GO:0045601)	2.78655373
100	cellular iron ion homeostasis (GO:0006879)	2.78220229

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.80159692
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.49397846
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.71452110
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.79349647
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.66846221
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.50317315
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.34494005
8	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.07598248
9	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.00085271
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	14.8571570
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.97233756
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.95369461
13	ZNF263_19887448_ChIP-Seq_K562_Human	1.95243208
14	VDR_22108803_ChIP-Seq_LS180_Human	1.92331675
15	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.92253869
16	AR_21909140_ChIP-Seq_LNCAP_Human	1.75308592
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.75187998
18	XRN2_22483619_ChIP-Seq_HELA_Human	1.66363590
19	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.64770527
20	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.61919905
21	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.57904639
22	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.54180909
23	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.47652502
24	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.47652502
25	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.47652502
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.45454084
27	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.41509341
28	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.37826585
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.31714091
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.30035593
31	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.25086185
32	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.24994274
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.21798889
34	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21448795
35	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.20945627
36	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.19399616
37	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.18121113
38	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.17976370
39	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.16151832
40	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.10650445
41	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.08570013
42	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.08372006
43	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.08160933
44	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.08020851
45	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.06109948
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.03868097
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.03534825
48	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.00982110
49	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.99044916
50	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.98885808
51	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.98150466
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.97790893
53	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.95837098
54	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95723793
55	TTF2_22483619_ChIP-Seq_HELA_Human	0.95515852
56	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.91515098
57	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.91099888
58	NCOR_22424771_ChIP-Seq_293T_Human	0.90934190
59	TP53_22573176_ChIP-Seq_HFKS_Human	0.89881894
60	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.89747457
61	E2F7_22180533_ChIP-Seq_HELA_Human	0.89466570
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.87859834
63	VDR_23849224_ChIP-Seq_CD4+_Human	0.87307980
64	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.87289332
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.85636869
66	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.85296021
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85253844
68	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.83374960
69	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.81401581
70	SOX2_22085726_ChIP-Seq_NPCs_Mouse	0.81367877
71	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.80918249
72	SOX2_20726797_ChIP-Seq_SW620_Human	0.78617525
73	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.76815914
74	STAT1_20625510_ChIP-Seq_HELA_Human	0.76422218
75	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.75936415
76	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.74881675
77	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.74777659
78	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.74670382
79	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.73824785
80	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.73513711
81	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.71824017
82	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.70197139
83	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.69873974
84	SA1_27219007_Chip-Seq_Bcells_Human	0.67304634
85	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.66549131
86	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.65239403
87	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.64503770
88	IRF1_19129219_ChIP-ChIP_H3396_Human	0.64098555
89	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.63250413
90	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.62101811
91	CTCF_27219007_Chip-Seq_Bcells_Human	0.60031670
92	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.59698080
93	GATA4_25053715_ChIP-Seq_YYC3_Human	0.59361448
94	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.59347426
95	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.59186313
96	TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.58603330
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.58187521
98	CTCF_20526341_ChIP-Seq_ESCs_Human	0.56942533
99	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.56840520
100	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.56162290

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008995_early_reproductive_senescence	4.76362450
2	MP0005670_abnormal_white_adipose	4.68488571
3	MP0005360_urolithiasis	4.38521764
4	MP0000013_abnormal_adipose_tissue	3.61847768
5	MP0002138_abnormal_hepatobiliary_system	3.59348718
6	MP0005646_abnormal_pituitary_gland	3.45930955
7	MP0003183_abnormal_peptide_metabolism	3.19734461
8	MP0002938_white_spotting	3.07865930
9	MP0003806_abnormal_nucleotide_metabolis	3.03743406
10	MP0005377_hearing/vestibular/ear_phenot	2.94595341
11	MP0003878_abnormal_ear_physiology	2.94595341
12	MP0002736_abnormal_nociception_after	2.86162873
13	MP0004885_abnormal_endolymph	2.38453475
14	MP0000566_synostosis	2.31891989
15	MP0003705_abnormal_hypodermis_morpholog	2.10871106
16	MP0003786_premature_aging	2.09550197
17	MP0004133_heterotaxia	2.08779665
18	MP0008872_abnormal_physiological_respon	2.05825776
19	MP0003186_abnormal_redox_activity	2.02380110
20	MP0004185_abnormal_adipocyte_glucose	1.97068851
21	MP0005084_abnormal_gallbladder_morpholo	1.90726304
22	MP0004147_increased_porphyrin_level	1.90116987
23	MP0001348_abnormal_lacrimal_gland	1.88761813
24	MP0002139_abnormal_hepatobiliary_system	1.84445702
25	MP0001764_abnormal_homeostasis	1.70946687
26	MP0002095_abnormal_skin_pigmentation	1.70547443
27	MP0005332_abnormal_amino_acid	1.70542657
28	MP0001661_extended_life_span	1.54849002
29	MP0001968_abnormal_touch/_nociception	1.53900817
30	MP0000647_abnormal_sebaceous_gland	1.50153241
31	MP0005367_renal/urinary_system_phenotyp	1.45051787
32	MP0000516_abnormal_urinary_system	1.45051787
33	MP0000026_abnormal_inner_ear	1.38724276
34	MP0006292_abnormal_olfactory_placode	1.38189762
35	MP0004019_abnormal_vitamin_homeostasis	1.38177803
36	MP0002396_abnormal_hematopoietic_system	1.37666062
37	MP0000015_abnormal_ear_pigmentation	1.35582654
38	MP0000003_abnormal_adipose_tissue	1.31963826
39	MP0001502_abnormal_circadian_rhythm	1.31275696
40	MP0002735_abnormal_chemical_nociception	1.30817218
41	MP0004130_abnormal_muscle_cell	1.30788289
42	MP0002697_abnormal_eye_size	1.26858909
43	MP0002098_abnormal_vibrissa_morphology	1.25494815
44	MP0001293_anophthalmia	1.18202664
45	MP0010030_abnormal_orbit_morphology	1.17471582
46	MP0000534_abnormal_ureter_morphology	1.16379347
47	MP0006035_abnormal_mitochondrial_morpho	1.15108363
48	MP0002277_abnormal_respiratory_mucosa	1.12449107
49	MP0000049_abnormal_middle_ear	1.12109304
50	MP0005645_abnormal_hypothalamus_physiol	1.12037404
51	MP0003942_abnormal_urinary_system	1.11895603
52	MP0000538_abnormal_urinary_bladder	1.10267904
53	MP0001270_distended_abdomen	1.09631266
54	MP0000762_abnormal_tongue_morphology	1.04984720
55	MP0003938_abnormal_ear_development	1.03265481
56	MP0002837_dystrophic_cardiac_calcinosis	1.02458154
57	MP0000631_abnormal_neuroendocrine_gland	1.00719348
58	MP0003283_abnormal_digestive_organ	1.00600923
59	MP0001905_abnormal_dopamine_level	1.00289848
60	MP0002132_abnormal_respiratory_system	0.97565374
61	MP0005636_abnormal_mineral_homeostasis	0.95340859
62	MP0003315_abnormal_perineum_morphology	0.94667141
63	MP0001944_abnormal_pancreas_morphology	0.93535807
64	MP0005076_abnormal_cell_differentiation	0.90041632
65	MP0002234_abnormal_pharynx_morphology	0.89673704
66	MP0004043_abnormal_pH_regulation	0.86917452
67	MP0000371_diluted_coat_color	0.86653525
68	MP0002876_abnormal_thyroid_physiology	0.85575083
69	MP0001666_abnormal_nutrient_absorption	0.84732279
70	MP0008875_abnormal_xenobiotic_pharmacok	0.84706730
71	MP0003937_abnormal_limbs/digits/tail_de	0.83941840
72	MP0005334_abnormal_fat_pad	0.83554137
73	MP0002210_abnormal_sex_determination	0.80386310
74	MP0000467_abnormal_esophagus_morphology	0.78357619
75	MP0001340_abnormal_eyelid_morphology	0.77687223
76	MP0001756_abnormal_urination	0.77033987
77	MP0005083_abnormal_biliary_tract	0.76888789
78	MP0002177_abnormal_outer_ear	0.76833713
79	MP0002069_abnormal_eating/drinking_beha	0.76275481
80	MP0000613_abnormal_salivary_gland	0.75456424
81	MP0008877_abnormal_DNA_methylation	0.75295810
82	MP0002295_abnormal_pulmonary_circulatio	0.73655685
83	MP0003252_abnormal_bile_duct	0.73368316
84	MP0003936_abnormal_reproductive_system	0.73189794
85	MP0000653_abnormal_sex_gland	0.71458188
86	MP0000579_abnormal_nail_morphology	0.71378206
87	MP0003693_abnormal_embryo_hatching	0.70798986
88	MP0009046_muscle_twitch	0.68069434
89	MP0005085_abnormal_gallbladder_physiolo	0.66528159
90	MP0003122_maternal_imprinting	0.65702370
91	MP0009643_abnormal_urine_homeostasis	0.65689880
92	MP0008058_abnormal_DNA_repair	0.65582158
93	MP0002184_abnormal_innervation	0.65405119
94	MP0002249_abnormal_larynx_morphology	0.64619536
95	MP0001145_abnormal_male_reproductive	0.61912925
96	MP0001286_abnormal_eye_development	0.61744383
97	MP0005551_abnormal_eye_electrophysiolog	0.61669733
98	MP0003879_abnormal_hair_cell	0.61441357
99	MP0003718_maternal_effect	0.59823565
100	MP0005220_abnormal_exocrine_pancreas	0.58309528

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	8.87323798
2	Hyperalaninemia (HP:0003348)	8.87323798
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	8.87323798
4	Congenital sensorineural hearing impairment (HP:0008527)	4.97988428
5	Esophageal varix (HP:0002040)	4.97308775
6	Decreased electroretinogram (ERG) amplitude (HP:0000654)	4.94680025
7	Homocystinuria (HP:0002156)	4.91620807
8	Abnormality of homocysteine metabolism (HP:0010919)	4.91620807
9	Constricted visual fields (HP:0001133)	4.79292423
10	Birth length less than 3rd percentile (HP:0003561)	4.12970271
11	Abnormality of the fetal cardiovascular system (HP:0010948)	4.00095847
12	Abnormal umbilical cord blood vessels (HP:0011403)	4.00095847
13	Single umbilical artery (HP:0001195)	4.00095847
14	Abnormality of serum amino acid levels (HP:0003112)	3.96094239
15	White forelock (HP:0002211)	3.83129862
16	Patchy hypopigmentation of hair (HP:0011365)	3.68310483
17	Abnormality of sulfur amino acid metabolism (HP:0004339)	3.46364307
18	Anorexia (HP:0002039)	3.45517732
19	Spontaneous hematomas (HP:0007420)	3.45306560
20	Myopathic facies (HP:0002058)	3.14997892
21	Methylmalonic acidemia (HP:0002912)	3.10986101
22	Conjugated hyperbilirubinemia (HP:0002908)	3.07966758
23	Pendular nystagmus (HP:0012043)	2.89738731
24	Megaloblastic anemia (HP:0001889)	2.89054784
25	Hypoplastic left heart (HP:0004383)	2.87612630
26	Myocardial infarction (HP:0001658)	2.83297226
27	Hypomagnesemia (HP:0002917)	2.83257020
28	Maternal diabetes (HP:0009800)	2.71818448
29	Abnormality of the umbilical cord (HP:0010881)	2.70209991
30	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.64169413
31	Ileus (HP:0002595)	2.63509159
32	Abnormal respiratory motile cilium morphology (HP:0005938)	2.53364182
33	Abnormal respiratory epithelium morphology (HP:0012253)	2.53364182
34	Cortical visual impairment (HP:0100704)	2.51668715
35	Hyperglycinemia (HP:0002154)	2.51013323
36	Abnormality of methionine metabolism (HP:0010901)	2.49327483
37	Macrocytic anemia (HP:0001972)	2.38385485
38	Tetany (HP:0001281)	2.38069922
39	Abnormality of magnesium homeostasis (HP:0004921)	2.36428224
40	Conjunctival telangiectasia (HP:0000524)	2.35487259
41	Chorioretinal atrophy (HP:0000533)	2.30225313
42	Attenuation of retinal blood vessels (HP:0007843)	2.29840430
43	Decreased subcutaneous fat (HP:0001002)	2.27003965
44	Methylmalonic aciduria (HP:0012120)	2.25585063
45	Visceral angiomatosis (HP:0100761)	2.25341333
46	Oligomenorrhea (HP:0000876)	2.24451754
47	Hypoplastic heart (HP:0001961)	2.23334650
48	Dyskinesia (HP:0100660)	2.22362035
49	Reduced subcutaneous adipose tissue (HP:0003758)	2.21082798
50	Chronic otitis media (HP:0000389)	2.18854941
51	Hyperuricemia (HP:0002149)	2.17824738
52	Increased purine levels (HP:0004368)	2.17824738
53	Action tremor (HP:0002345)	2.16042879
54	Poor speech (HP:0002465)	2.15130867
55	Stenosis of the external auditory canal (HP:0000402)	2.14966280
56	Insulin-resistant diabetes mellitus (HP:0000831)	2.14607784
57	Hypopigmentation of the fundus (HP:0007894)	2.12448731
58	Hyperphosphatemia (HP:0002905)	2.11903007
59	Hemangiomatosis (HP:0007461)	2.09445882
60	Heterochromia iridis (HP:0001100)	2.06577430
61	Pallor (HP:0000980)	2.02323828
62	Small hand (HP:0200055)	2.00948505
63	Choroideremia (HP:0001139)	1.98559433
64	Lactic acidosis (HP:0003128)	1.97899802
65	Chronic hepatic failure (HP:0100626)	1.95152170
66	Abnormal tarsal ossification (HP:0008369)	1.92892893
67	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.91257080
68	Generalized aminoaciduria (HP:0002909)	1.91100128
69	Ectopic anus (HP:0004397)	1.90445062
70	Hypoalphalipoproteinemia (HP:0003233)	1.89360182
71	Supernumerary spleens (HP:0009799)	1.89212031
72	Cheilitis (HP:0100825)	1.88663979
73	Chronic sinusitis (HP:0011109)	1.87034556
74	Hyperphosphaturia (HP:0003109)	1.86639969
75	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86396167
76	Nausea (HP:0002018)	1.86110485
77	Increased serum lactate (HP:0002151)	1.85674934
78	Myelomeningocele (HP:0002475)	1.80531820
79	Abnormal rod and cone electroretinograms (HP:0008323)	1.80375497
80	Long clavicles (HP:0000890)	1.79154792
81	Toxemia of pregnancy (HP:0100603)	1.78586605
82	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.78409816
83	Brittle hair (HP:0002299)	1.78316498
84	Proximal tubulopathy (HP:0000114)	1.77320964
85	Abnormality of subcutaneous fat tissue (HP:0001001)	1.77099987
86	Reticulocytopenia (HP:0001896)	1.76423957
87	Parakeratosis (HP:0001036)	1.73972502
88	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.73320336
89	Pigmentary retinal degeneration (HP:0001146)	1.73046072
90	3-Methylglutaconic aciduria (HP:0003535)	1.72243770
91	Abnormality of alkaline phosphatase activity (HP:0004379)	1.70948962
92	Metabolic acidosis (HP:0001942)	1.69273207
93	Abnormalities of placenta or umbilical cord (HP:0001194)	1.69172590
94	Abnormality of the labia minora (HP:0012880)	1.68833204
95	Neutropenia (HP:0001875)	1.68374501
96	Abnormality of the tricuspid valve (HP:0001702)	1.67327691
97	Abnormal ciliary motility (HP:0012262)	1.65389698
98	Lethargy (HP:0001254)	1.64729890
99	Abnormal enzyme/coenzyme activity (HP:0012379)	1.62995859
100	Hypoparathyroidism (HP:0000829)	1.62496539

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RPS6KB2	3.55438711
2	MAP3K3	3.50574287
3	MAP2K7	3.28401395
4	VRK2	3.22593423
5	WNK4	3.18928967
6	NTRK2	3.02705650
7	EPHB2	2.83557612
8	FGR	2.79242064
9	EPHA2	2.72853671
10	MAP2K3	2.68442249
11	DYRK3	2.51270487
12	JAK3	2.50194734
13	CDK9	2.24078170
14	PINK1	2.15383911
15	ZAK	2.15356246
16	ACVR1B	2.13499145
17	TAF1	2.07419988
18	LMTK2	1.91769162
19	EIF2AK1	1.86075458
20	STK39	1.83288660
21	MAP3K4	1.67632865
22	OXSR1	1.66766585
23	TLK1	1.65019161
24	PDK2	1.61268799
25	DYRK2	1.57334297
26	VRK1	1.54966793
27	NTRK3	1.53308669
28	CCNB1	1.48582510
29	SGK223	1.30058905
30	SGK494	1.30058905
31	YES1	1.29265456
32	SRPK1	1.18892202
33	TRIM28	1.07583550
34	SGK2	1.00505341
35	ABL2	0.95369947
36	PRKCI	0.92344333
37	TYRO3	0.91891758
38	AURKA	0.89273780
39	NEK6	0.89081059
40	CSNK1A1	0.88213553
41	PASK	0.84392914
42	DYRK1A	0.80865037
43	MELK	0.80426610
44	CAMK2D	0.79973769
45	ADRBK1	0.79941456
46	WEE1	0.78629972
47	CDK19	0.77866509
48	NEK1	0.76558562
49	CAMK2B	0.75816091
50	CAMK2G	0.69347300
51	BUB1	0.68351523
52	PTK6	0.67023470
53	CDC7	0.66310737
54	DYRK1B	0.63305776
55	UHMK1	0.62963144
56	MAP2K1	0.61768844
57	PHKG1	0.59699852
58	PHKG2	0.59699852
59	TAOK3	0.58923894
60	GRK1	0.58740339
61	FGFR2	0.58248641
62	LIMK1	0.58127510
63	PAK4	0.56092653
64	CAMK1	0.54068097
65	TAOK1	0.53674329
66	RPS6KA5	0.53215612
67	SGK3	0.53151772
68	PNCK	0.53131604
69	PRKCD	0.51773744
70	SMG1	0.50587085
71	ADRBK2	0.49641011
72	PBK	0.47171440
73	STK16	0.46808145
74	MAP3K6	0.45828083
75	BCKDK	0.44666092
76	PLK1	0.43351781
77	TESK1	0.43237224
78	EGFR	0.42553983
79	AKT2	0.42049202
80	SGK1	0.40649129
81	INSRR	0.39785539
82	INSR	0.37975707
83	MAP2K4	0.36184828
84	MAPK15	0.35501762
85	AURKB	0.32534609
86	CDK5	0.31708350
87	CSNK2A1	0.30837131
88	PRKCE	0.30367825
89	MAP3K8	0.29522339
90	TGFBR1	0.28806970
91	PRKCA	0.27480635
92	CDK7	0.25359541
93	PRKG2	0.25295291
94	ERBB2	0.24743894
95	CSNK1G1	0.24616822
96	MARK1	0.23565090
97	MAP3K11	0.23395497
98	IKBKB	0.23378737
99	PLK3	0.23370464
100	RPS6KA1	0.23349079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	One carbon pool by folate_Homo sapiens_hsa00670	3.89717324
2	Collecting duct acid secretion_Homo sapiens_hsa04966	3.62151560
3	Sulfur relay system_Homo sapiens_hsa04122	3.34446059
4	Ribosome_Homo sapiens_hsa03010	3.18517381
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.01447021
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.70843695
7	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	2.61241602
8	Arginine biosynthesis_Homo sapiens_hsa00220	2.59768796
9	Proteasome_Homo sapiens_hsa03050	2.41261786
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	2.32258623
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.22366915
12	Vibrio cholerae infection_Homo sapiens_hsa05110	2.06160263
13	Cysteine and methionine metabolism_Homo sapiens_hsa00270	2.04665320
14	Sulfur metabolism_Homo sapiens_hsa00920	2.01693283
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.95188721
16	Galactose metabolism_Homo sapiens_hsa00052	1.86062625
17	Folate biosynthesis_Homo sapiens_hsa00790	1.84343393
18	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.81069076
19	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.79265637
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.59366663
21	Parkinsons disease_Homo sapiens_hsa05012	1.54814027
22	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.45587425
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44060643
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43484388
25	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.41083176
26	GABAergic synapse_Homo sapiens_hsa04727	1.37483082
27	Huntingtons disease_Homo sapiens_hsa05016	1.29580044
28	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.27114498
29	Nicotine addiction_Homo sapiens_hsa05033	1.25924051
30	Basal transcription factors_Homo sapiens_hsa03022	1.25349700
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21756065
32	RNA degradation_Homo sapiens_hsa03018	1.20029871
33	Spliceosome_Homo sapiens_hsa03040	1.16417818
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14294108
35	Retinol metabolism_Homo sapiens_hsa00830	1.11886478
36	Morphine addiction_Homo sapiens_hsa05032	1.09549049
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.08601811
38	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.08075952
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.07648983
40	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.04784544
41	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	1.04617202
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.04456918
43	Base excision repair_Homo sapiens_hsa03410	1.03606707
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01575219
45	Ether lipid metabolism_Homo sapiens_hsa00565	1.01125233
46	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.00234207
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.99796732
48	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97929615
49	RNA polymerase_Homo sapiens_hsa03020	0.92471736
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90030399
51	RNA transport_Homo sapiens_hsa03013	0.89631842
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.87725903
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.86077823
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.84542157
55	Peroxisome_Homo sapiens_hsa04146	0.84176175
56	DNA replication_Homo sapiens_hsa03030	0.83343711
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.83234534
58	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.82834598
59	Metabolic pathways_Homo sapiens_hsa01100	0.82649384
60	Alzheimers disease_Homo sapiens_hsa05010	0.80136599
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.79568449
62	Mismatch repair_Homo sapiens_hsa03430	0.76304535
63	Fatty acid elongation_Homo sapiens_hsa00062	0.71487630
64	Glutathione metabolism_Homo sapiens_hsa00480	0.68434213
65	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.67273358
66	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65334663
67	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60486067
68	Protein export_Homo sapiens_hsa03060	0.60479412
69	Dopaminergic synapse_Homo sapiens_hsa04728	0.60244892
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58035755
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.57551352
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57508499
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.55081614
74	Histidine metabolism_Homo sapiens_hsa00340	0.52796675
75	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50361489
76	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49807097
77	Tyrosine metabolism_Homo sapiens_hsa00350	0.45970981
78	Alcoholism_Homo sapiens_hsa05034	0.43656478
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43632876
80	Regulation of autophagy_Homo sapiens_hsa04140	0.43138048
81	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.42975376
82	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.42829463
83	Glutamatergic synapse_Homo sapiens_hsa04724	0.40886145
84	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40714362
85	Purine metabolism_Homo sapiens_hsa00230	0.38550398
86	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37774327
87	Tight junction_Homo sapiens_hsa04530	0.37495216
88	Taste transduction_Homo sapiens_hsa04742	0.36858868
89	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.36291438
90	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.35603963
91	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35540401
92	Nucleotide excision repair_Homo sapiens_hsa03420	0.35158028
93	Circadian entrainment_Homo sapiens_hsa04713	0.34787090
94	Homologous recombination_Homo sapiens_hsa03440	0.34743027
95	Serotonergic synapse_Homo sapiens_hsa04726	0.34448566
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.33577771
97	Caffeine metabolism_Homo sapiens_hsa00232	0.33553267
98	Phenylalanine metabolism_Homo sapiens_hsa00360	0.33436616
99	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.33190307
100	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33131375

KRT18P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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